八周高强度间歇训练对心肌梗死大鼠快慢肌肌动蛋白基因表达的影响

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Edris Ramezani, Mehran Ghahramani, Hadi Ghaedi
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引用次数: 0

摘要

背景:心肌梗塞会导致线粒体萎缩,并通过减少线粒体体积而丧失功能。因此,研究人员希望找到减少损伤和治疗损伤的方法。本研究旨在评估 8 周高强度间歇训练对心肌梗死大鼠快慢肌中follistatin(FST)基因表达的影响:这项研究于 2020 年在伊朗德黑兰沙希德-拉贾伊医科大学心脏研究中心进行。为此,将 12 只患有心肌梗死的雄性 Wistar 大鼠分为实验组和对照组,实验组进行高强度间歇训练(每周 3 天,每次 30 分钟,每次间歇包括 4 分钟强度为 85-90% VO2max 的跑步和 2 分钟强度为 50-60% VO2max 的主动恢复,持续 8 周)。然后,研究了快慢肌收缩基因中follistatin的表达,将其作为肌肉萎缩的诱发因素和抑制因素。统计数据用 SPSS18 进行分析(α≥0.05)。为确定数据的正态性,使用了 Kolmogorov-Smirnov 检验,在数据分布正态的情况下,使用了独立样本 t 检验:独立 t 检验结果表明,与对照组相比,慢肌收缩组的 FST 基因表达量明显下降(PC 结论:总的来说,8 周的高强度间歇运动对肌肉的生长和发育都有影响:总体而言,8 周的高强度间歇运动会降低心肌梗死大鼠慢肌和快肌的 FST 基因表达。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Eight Weeks of High-Intensity Interval Training on Follistatin Gene Expression in the Fast and Slow Twitch Muscles of Rats with Myocardial Infarction.

Background: Myocardial infarction causes mitochondrial atrophy and loss of function by reducing mitochondrial volume. Therefore, researchers are interested in finding a way to reduce the injuries and treat them. The study aims to evaluate the effect of 8 weeks of high-intensity interval training on follistatin (FST) gene expression in the fast and slow twitch muscles of rats with myocardial infarction.

Methods: The study was conducted in 2020 at the Cardiac Research Center, Shahid Rajaei University of Medical Sciences (Tehran, Iran). For this purpose, 12 male Wistar rats with myocardial infarction were assigned to the experimental group high-intensity interval training (3 days a week for 30 min, each interval consisting of 4 min of running with 85-90% VO2max intensity and 2 min of active recovery with intensity of 50-60% VO2max for 8 weeks) and a control group. Then, the expression of follistatin in fast and slow twitch muscle contraction genes was investigated as triggers and inhibitors of muscle atrophy. Statistical data were analyzed with SPSS18 (α≥0.05). To determine the normality of the data, the Kolmogorov-Smirnov test was used, and in the case of normality of the data distribution, the independent samples t test was used.

Results: Independent t test results showed that FST gene expression in the slow twitch (ST) muscle contraction group was significantly decreased compared with the control group (P<0.001). Moreover, the expression of the FST gene in fast twitch muscles was significantly increased in the severe exercise group compared with the control group (P<0.001).

Conclusion: Overall, 8 weeks of intense intermittent exercise decreased FST gene expression in slow and fast twitch muscles in rats with myocardial infarction.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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