International Urology and Nephrology最新文献

{"title":"Association of serum Klotho and fibroblast growth factor-23 levels with vascular calcification severity in patients with chronic kidney disease: an observational cohort study.","authors":"Pei-Shan Peng, Wei Lu","doi":"10.1007/s11255-025-04475-5","DOIUrl":"https://doi.org/10.1007/s11255-025-04475-5","url":null,"abstract":"<p><strong>Purpose: </strong>In patients with chronic kidney disease (CKD), vascular calcification (VC) is common and influences patient's outcome and prognosis. However, evaluation methods for VC severity are limited. Klotho and fibroblast growth factor-23 (FGF-23) are biomarkers associating with VC development. This study aimed to explore the association of serum Klotho and FGF-23 levels with VC severity in patients with non-dialysis CKD.</p><p><strong>Methods: </strong>Patients with non-dialysis CKD were enrolled during hospitalization and were divided into the following four groups on the basis of their coronary artery calcification (CAC) scores: non-VC (CAC scores = 0), mild VC (0 < CAC scores ≤ 100), moderate VC (100 < CAC scores ≤ 400), and severe VC groups (CAC scores > 400). Serum Klotho and FGF-23 levels among the different groups were compared.</p><p><strong>Results: </strong>A total of 154 non-dialysis CKD patients were enrolled. Correlation analysis showed that serum FGF-23 level (rho = 0.185, p = 0.022) was positively correlated with VC severity, whereas serum Klotho level (rho =  -  0.196, p = 0.015) was negatively correlated with VC severity in patients with CKD. Multivariable regression analysis showed that Klotho level [odd ratio (OR) = 0.998, 95% confidence interval (CI) 0.996-0.999, p = 0.001] served as a protective factor for VC severity in patients with CKD, whereas FGF-23 level (OR = 1.005, 95% CI 1.001-1.009, p = 0.020) was identified as risk factor for VC severity.</p><p><strong>Conclusion: </strong>Serum Klotho and FGF-23 levels are potential predictors of VC severity in patients with non-dialysis CKD.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A step forward in cardiovascular and renal protection: advocating for finerenone's use in Pakistan.","authors":"Sarah Aijaz, Marriam Tanvir, Syed Muhammad Rehman Shah, Ali Tanvir","doi":"10.1007/s11255-024-04228-w","DOIUrl":"10.1007/s11255-024-04228-w","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1349-1350"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of modest intake of soy milk enriched with Lactobacillus casei and omega-3 on the testis parameters in diabetic rats: a stereological study.","authors":"Maryam Bayat, Farhad Koohpeyma, Nima Montazeri-Najafabady, Mohammad Hossein Dabbaghmanesh, Naeimehossadat Asmarian, Seyyed Iman Hosseini","doi":"10.1007/s11255-024-04243-x","DOIUrl":"10.1007/s11255-024-04243-x","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus is a widely distributed endocrine disorder in the world. Altered reproductive function is a notable long-term consequence of type 1 diabetes mellitus (T1DM). In the current study, we assessed the effects of soya milk containing Lactobacillus casei and omega-3 on stereology of testes in type 1 diabetic rats.</p><p><strong>Methods: </strong>30 male Sprague Dawley rats were randomly allocated into five groups. Streptozocin (STZ (60 mg/kg)) was applied for diabetes induction. The non-diabetic and diabetic control groups were fed with 1 ml of distilled water. Three treatment diabetic groups were fed 1 ml of Soy milk group (SM), Probiotic soy milk group (PSM), and Omega-3 probiotic soy milk group (OPSM) via intragastric gavage for 60 days. At the endpoint, the animals were sacrificed and serum luteinizing hormone (LH), Follicle-stimulating hormone (FSH), testosterone, MDA besides testicular, and seminal parameters were analyzed.</p><p><strong>Results: </strong>The administration of soy milk supplemented with L. casei and omega-3 in diabetic rats elevated the concentrations of LH, FSH, testosterone, and reduced malondialdehyde (MDA). In addition, this combination improved sperm quality, enhanced the number of sperm with rapid progress, increased testis weight and volume, seminiferous tubule and germinal epithelium volume; and also augmented the number of spermatogonia, spermatocyte, round and long spermatids, Sertoli cells and Leydig cells.</p><p><strong>Conclusion: </strong>Supplementation with soy milk containing L. casei and omega-3 can inhibit T1DM-induced infertility rats through improving testicular parameters, enhancing sperm quality, and increasing Sertoli and Leydig cell number.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1123-1133"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142728737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic efficacy of combined high- and low-frequency ultrasound in post-hematopoietic stem cell transplantation ureteral obstruction in leukemia patients.","authors":"Zhiyan Zhao, Junfang Yang, Xiuzhi Wang, Xin Wang, Yaru Luan","doi":"10.1007/s11255-024-04291-3","DOIUrl":"10.1007/s11255-024-04291-3","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this study was to evaluate the diagnostic efficacy of high- and low-frequency ultrasound (H&LFUS) in the imaging of post-hematopoietic stem cell transplantation (post-HSCT) ureteral obstruction in leukemia patients.</p><p><strong>Methods: </strong>A total of 103 patients who received HSCT for leukemia were included in this retrospective study. Patients underwent examinations using high-frequency ultrasound (HFUS), low-frequency ultrasound (LFUS), and the combined use of H&LFUS approach. Baseline data, clinical laboratory parameters, and clinical parameters were compared among the groups. Ultrasound findings and diagnostic sensitivity, specificity and accuracy were also analyzed to assess the diagnostic value of the imaging modalities.</p><p><strong>Results: </strong>The investigation demonstrated no statistically significant distinctions in demographic, baseline, and clinical parameters among the HFUS group, LFUS group, and H&LFUS group. Nonetheless, notable differences emerged in the detection rates of specific ultrasound abnormalities, encompassing ureteral dilatation, wall thickening, urine flow obstruction, hydronephrosis, bladder wall thickening, and renal masses. Regarding diagnostic performance metrics, H&LFUS approach exhibited superior efficacy across sensitivity, specificity, and overall accuracy, registering rates of 91.43%, 88.57%, and 90%, respectively, surpassing those of the individual HFUS and LFUS methodologies.</p><p><strong>Conclusion: </strong>The amalgamation of H&LFUS techniques manifests as a formidable diagnostic modality, characterized by heightened sensitivity, specificity, and diagnostic accuracy.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1289-1296"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpression of BMAL-1 is related to progression of urothelial carcinoma in arsenic exposure area.","authors":"Yu-Jui Wu, Shu-Jyuan Chang, Yen-Shuo Huang, Chee-Yin Chai","doi":"10.1007/s11255-024-04320-1","DOIUrl":"10.1007/s11255-024-04320-1","url":null,"abstract":"<p><strong>Background: </strong>Environmental exposure to arsenic has long been associated with various clinical and pathophysiological aspects of urothelial carcinoma (UC), although the role of arsenic in UC and its impact on circadian proteins, particularly BMAL-1, remains unestablished. Previous research suggests that arsenic upregulates Aurora kinase A (AURKA), subsequently inhibiting GSK-3β, which might lead to overexpression of BMAL-1; nevertheless, the underlying pathway and its clinical significance in UC with arsenic exposure have yet to be validated. This study focuses on two potential upstream regulators of BMAL-1, AURKA and GSK-3β.</p><p><strong>Methods: </strong>Ninety-nine tumor tissue samples were retrospectively collected along with their respective clinical data. Immunohistochemistry was employed to assess the expression of each protein.</p><p><strong>Results: </strong>A positive relationship was observed between the expression levels of AURKA and BMAL-1 (p < 0.001), while negative correlations were noted between the expression levels of GSK-3β and AURKA (p < 0.001), and between GSK-3β and BMAL-1 (p = 0.003). Tissue samples exposed to arsenic exhibited significantly higher levels of AURKA (p < 0.001) and BMAL-1 (p < 0.001), a markedly lower expression of GSK-3β (p = 0.001), alongside a decreased survival status (p = 0.025) compared to non-exposed samples. Furthermore, patients with UC of higher tumor grade tended to show increased levels of AURKA (p < 0.001), BMAL-1 (p < 0.001), and decreased levels of GSK-3β (p < 0.001). Elevated expression of AURKA (p < 0.001) and BMAL-1 (p = 0.002), as well as reduced expression of GSK-3β (p = 0.003), were also associated with a decreased survival status.</p><p><strong>Conclusions: </strong>This study highlights the differential expression of BMAL-1, AURKA, and GSK-3β in association with arsenic exposure and their significant impact on clinical and pathological features of UC. Moreover, BMAL-1, AURKA, and GSK-3β emerge as potential prognostic markers for UC in regions with arsenic exposure.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1175-1187"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, risk factors, and severity of erectile dysfunction following renal transplantation.","authors":"Adelina Miron, Ionuț Nistor, Corneliu Moroșanu, Lucian Sirițeanu, Catalin Pricop, Dragos Puia, Adrian Covic","doi":"10.1007/s11255-024-04299-9","DOIUrl":"10.1007/s11255-024-04299-9","url":null,"abstract":"<p><strong>Background: </strong>Sexual dysfunction is common among dialysis and transplant patients. Our study evaluated the prevalence, risk factors, and severity of erectile dysfunction (ED) post-transplant in a single center.</p><p><strong>Methods: </strong>We conducted a single-centre, observational, non-interventional study of adult male renal graft recipients. Sociodemographic and clinical data were collected, and erectile function was assessed with the International Index of Erectile Function (IIEF) questionnaire.</p><p><strong>Results: </strong>179 patients transplanted between 1995 and 2021 were enrolled (170 answered the questionnaire). Mild, moderate, and severe ED was noted in 33.5%, 20.6% and 10.6% of cases, respectively. ED prevalence increased with age (42.6% of patients < 40, 47.4% of patients aged 40-60, 78.9% of patients > 60). The total mean IIEF score was 16.32 ± 6.93 (erectile function 19.22 ± 7.9, orgasmic function 6.8 ± 2.9, sexual desire 6.43 ± 2.1, intercourse satisfaction 8.96 ± 3.7, overall satisfaction 6.78 ± 2.6). Age, alcohol consumption, type, time on dialysis pre-transplant, and donor type were significantly associated with erectile dysfunction (p < 0.05). Most patients (93.5%) were treated for comorbidities in addition to immunosuppression. Severe ED was significantly more common among patients taking alpha blockers and non-steroidal anti-inflammatory drugs.</p><p><strong>Conclusions: </strong>Self-reported erectile dysfunction post renal transplantation seems influenced by age, alcohol intake, dialysis history, donor type and certain drugs, but not by comorbidities (hypertension, diabetes, heart disease).</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1151-1173"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of nine south eastern European transplant centers with testicular cancer in kidney transplant recipients.","authors":"Mirha Pjanic, Ivana Juric, Miha Arnol, Damir Rebic, Mirna Aleckovic-Halilovic, Marija Milinkovic, Danilo Radunovic, Zeljko Kastelan, Nikolina Basic-Jukic","doi":"10.1007/s11255-025-04488-0","DOIUrl":"https://doi.org/10.1007/s11255-025-04488-0","url":null,"abstract":"<p><strong>Purpose: </strong>Testicular cancer (TC) is the most common type of cancer among young men aged 25 to 45. This study represents the first population study of TC in kidney transplant recipients (KTRs).</p><p><strong>Methods: </strong>We conducted a multicentric, multinational, cross-sectional study across nine transplant centers in Croatia, Serbia, Montenegro, Slovenia, and Bosnia and Herzegovina. All KTRs over 18 years old who were regularly monitored at their transplant centers were included. Data were collected from electronic medical records at these centers.</p><p><strong>Results: </strong>Out of the 4426 KTRs who participated in our study, six (0.14%) developed TC after KT. Two of these patients had a history of malignancy before KT, while four had a positive family history of malignancy. The median age at diagnosis of TC was 41 years. Follow-up time ranged from 1 to 14 years. Most of the patients underwent surgical treatment and half received adjuvant chemotherapy and/or radiotherapy. Four patients had seminoma and two had non-seminoma. In most cases, the immunosuppressive therapy was adjusted. Half of the patients maintained stable kidney allograft function after TC treatment. One patient died due to COVID-19 and two required chronic dialysis 8-9 years after their TC diagnosis and treatment.</p><p><strong>Conclusions: </strong>In our study, TC occurred in the same age range as in the general population. A personal or family history of malignancy was identified as a significant risk factor. Outcomes for kidney allograft function and overall survival were excellent for patients whose disease was detected early and treated with orchiectomy. Switching from calcineurin to mTOR inhibitors also supported allograft survival.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of suction technique and non-suction technique in retrograde intrarenal stone surgery: a systematic review and meta-analysis.","authors":"Pengan Chen, Gaoshen Mi, Jixiang Chen, Yu Liu, Zhongyu Jian, Xi Jin, Kunjie Wang","doi":"10.1007/s11255-024-04280-6","DOIUrl":"10.1007/s11255-024-04280-6","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of retrograde intrarenal stone surgery (RIRS) using the vacuum suction technique for the treatment of upper urinary calculi.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases, including PubMed, Embase, Sino Med, CNKI, WANFANG DATA, and Cochrane. We included studies comparing vacuum suction RIRS with non-vacuum RIRS. Following the PRISMA guidelines, we performed a meta-analysis of the selected studies. Inclusion criteria were randomized controlled trials (RCTs), case-control studies, and retrospective studies evaluating the efficacy of these techniques. Key outcomes analyzed included operative time, hospitalization duration, stone-free rates, and complication rates. Statistical analyses were conducted using mean differences (MD) for continuous variables and odds ratios (OR) for dichotomous outcomes, with corresponding 95% confidence intervals (CI).</p><p><strong>Results: </strong>Sixteen studies (6 RCTs, 1 case-control study, and 9 retrospective studies) involving a total of 2029 patients were included. Meta-analysis revealed that the vacuum suction technique significantly reduced operative time (MD = - 14.45 min, 95% CI [- 18.45; - 10.44], P < 0.00001) and hospital stay (MD = - 0.54 days, 95% CI [- 0.80; - 0.28], P < 0.00001). In addition, patients in the vacuum suction group had a higher stone-free rate (OR = 3.57, 95% CI [2.57; 4.95], P < 0.00001) and lower complication rates, particularly in reducing postoperative fever.</p><p><strong>Conclusion: </strong>The application of the vacuum suction technique in RIRS significantly improves clinical outcomes by reducing operative time and hospitalization duration, enhancing stone-free rates, and lowering postoperative complication rates. This technique demonstrates a clear clinical advantage over non-vacuum RIRS and should be considered a preferred option for the management of upper urinary tract stones.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1051-1062"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussion on the treatment of diabetic kidney disease based on the \"gut-fat-kidney\" axis.","authors":"Yaping He, Dengke Jia, Wenying Chen, Juan Liu, Congrong Liu, Xiaowei Shi","doi":"10.1007/s11255-024-04283-3","DOIUrl":"10.1007/s11255-024-04283-3","url":null,"abstract":"<p><p>Diabetic kidney disease is the main cause of end-stage renal disease, and its prevention and treatment are still a major clinical problem. The human intestine has a complex flora of hundreds of millions of microorganisms, and intestinal microorganisms, and their derivatives are closely related to renal inflammatory response, immune response, and material metabolism. Brown adipose tissue is the main part of adaptive thermogenesis. Recent studies have shown that activating brown fat by regulating intestinal flora has good curative effects in diabetic kidney disease-related diseases. As an emerging medical concept, the \"gut-fat-kidney\" axis has received increasing attention in diabetic kidney disease and related diseases. However, the specific mechanism involved needs further study. A new theoretical basis for the prevention and treatment of diabetic kidney disease is presented in this article, based on the \"gut-fat-kidney\" axis.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1233-1243"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing AI for real-time monitoring and precision medicine: enhancing cardiovascular risk prediction in CKD management through panimmune-inflammation value.","authors":"Anshal Ahmad, Rayyan Nabi, Dure Shehwar","doi":"10.1007/s11255-025-04482-6","DOIUrl":"https://doi.org/10.1007/s11255-025-04482-6","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}