International Urology and Nephrology最新文献

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A real-world evidence study of interhospital variability in the surgical treatment of patients with benign prostatic hyperplasia: the REVALURO study. 良性前列腺增生症患者手术治疗中医院间差异的真实证据研究:REVALURO 研究。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-03-01 Epub Date: 2024-10-29 DOI: 10.1007/s11255-024-04239-7
Povo Martín Iván, Budía Alba Alberto, Peri Cusí Lluís, D'Anna Maurizio, Gutiérrez Baños Jose Luís, Vicente Prados Francisco Javier, Sabio Bonilla Almudena, García Herrero Jaime, Torres Mingorance Esperanza, Bretos Azcona Pablo, Ojeda Arqueros Gabriela, Gómez-Barrera Manuel, Casado Miguel Ángel, de la Cuadra-Grande Alberto, López Alcina Emilio
{"title":"A real-world evidence study of interhospital variability in the surgical treatment of patients with benign prostatic hyperplasia: the REVALURO study.","authors":"Povo Martín Iván, Budía Alba Alberto, Peri Cusí Lluís, D'Anna Maurizio, Gutiérrez Baños Jose Luís, Vicente Prados Francisco Javier, Sabio Bonilla Almudena, García Herrero Jaime, Torres Mingorance Esperanza, Bretos Azcona Pablo, Ojeda Arqueros Gabriela, Gómez-Barrera Manuel, Casado Miguel Ángel, de la Cuadra-Grande Alberto, López Alcina Emilio","doi":"10.1007/s11255-024-04239-7","DOIUrl":"10.1007/s11255-024-04239-7","url":null,"abstract":"<p><strong>Purpose: </strong>Lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) is a growing condition in males associated with a high clinical, economic and humanistic burden. Several surgical techniques are available for the treatment of LUTS/BPH; thus, the aim of this study was to describe and explore the variability in the use of surgical procedures among Spanish hospitals.</p><p><strong>Methods: </strong>The REVALURO was a retrospective, observational study conducted by collecting data from the clinical records of patients with LUTS/BPH aged ≥ 35 years, from 5 national reference hospitals, who were surgically treated between 2018 and 2022.</p><p><strong>Results: </strong>Among the 3038 patients who underwent 3084 surgeries, 66% were invasive (2018: 57.5%, 2022: 71.5%), 22% were minimally invasive (MISTs) (2018: 20.7%, 2022: 20.2%) and 12% were highly invasive (2018: 21.8%, 2022: 8.4%). A total of 22.4% of patients' complications, with a maximum incidence of 28.6% (open prostatectomy) and a minimum 0.8% (water vapor thermal therapy (WVTT)] (p < 0.001). The reintervention rate was 1.5% over the study period. The median length of hospital stay after surgery increased from 0 days (interquartile range [IQR]: 0) with WVTT to 5 days (IQR: 4-8) with open prostatectomy (p < 0.001).</p><p><strong>Conclusion: </strong>Trends in surgical treatment showed that the use of invasive techniques increased, while the use of highly invasive techniques decreased, and the use of MISTs remained constant. However, given the heterogeneity among hospitals, national clinical guidelines and recommendations are needed to guide the decision on which technique should be used and to homogenize the criteria.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"775-784"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the impact of semaglutide on renal function. 探索semaglutide对肾功能的影响。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-03-01 Epub Date: 2024-09-23 DOI: 10.1007/s11255-024-04215-1
Nirmal Noor, Rahat Khatoon, Duroove Kumar
{"title":"Exploring the impact of semaglutide on renal function.","authors":"Nirmal Noor, Rahat Khatoon, Duroove Kumar","doi":"10.1007/s11255-024-04215-1","DOIUrl":"10.1007/s11255-024-04215-1","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1029-1030"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of laparoscopic-assisted flexible ureteroscopic lithotripsy with percutaneous nephrolithotripsy and flexible ureteroscopy lithotripsy: a case-control study and meta-analysis. 腹腔镜辅助柔性输尿管镜碎石术与经皮肾镜碎石术和柔性输尿管镜碎石术的比较:病例对照研究和荟萃分析。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-03-01 Epub Date: 2024-10-23 DOI: 10.1007/s11255-024-04250-y
Jia Wei He, Yan Feng Su
{"title":"Comparison of laparoscopic-assisted flexible ureteroscopic lithotripsy with percutaneous nephrolithotripsy and flexible ureteroscopy lithotripsy: a case-control study and meta-analysis.","authors":"Jia Wei He, Yan Feng Su","doi":"10.1007/s11255-024-04250-y","DOIUrl":"10.1007/s11255-024-04250-y","url":null,"abstract":"<p><strong>Background: </strong>This study aims to compare the differences in stone clearance rate, infection rate, and bleeding risk among laparoscopic-assisted flexible ureteroscopic lithotripsy (LAFUL), percutaneous nephrolithotripsy (PCNL), and flexible ureteroscopic lithotripsy (FUL) through case-control studies and meta-analysis, to evaluate the safety and effectiveness of LAFUL.</p><p><strong>Methods: </strong>1. Through systematic literature search, clinical studies related to LAFUL, PCNL, and FUL were screened, and data on stone clearance rate, infection rate, and bleeding events were collected and analyzed for three groups of patients, followed by meta-analysis. 2. Data of patients who met the single center inclusion criteria and received LAFUL (40 cases), PCNL (40 cases, FUL), and FUL (40 cases) treatments for kidney stones from January 2021 to December 2023 were collected. Using a case-control study method, relevant clinical data were analyzed using SPSS 26.0 software.</p><p><strong>Results: </strong>A total of 31 studies involving 2974 patients were included. The results of case-control analysis showed the stone clearance rate in the LAFUL group (F = 225.19, P < 0.001) and the positive rate of postoperative urine bacterial culture (X<sup>2</sup> = 4.558, P = 0.033). The results of meta-analysis showed the stone clearance rate (rate = 0.986, 95% CI 0.964-0.999) and blood transfusion rate (rate = 0, 95% CI 0-0.012) in the LAFUL group.</p><p><strong>Conclusion: </strong>LAFUL shows potential in improving the stone clearance rate and reducing the risk of postoperative infection and bleeding, suggesting it may have certain advantages in the treatment of renal calculi.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"741-751"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between the risk of atherosclerotic cardiovascular disease and decreased functional bladder capacity. 动脉粥样硬化性心血管疾病风险与功能性膀胱容量下降之间的关系。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-03-01 Epub Date: 2024-10-23 DOI: 10.1007/s11255-024-04241-z
Ali Hamidi Madani, Bahador Heidari Bateni, Aseme Pourrajabi, Ehsan Kazemnezhad Leyli, Mohammad Hamidi Madani
{"title":"Relationship between the risk of atherosclerotic cardiovascular disease and decreased functional bladder capacity.","authors":"Ali Hamidi Madani, Bahador Heidari Bateni, Aseme Pourrajabi, Ehsan Kazemnezhad Leyli, Mohammad Hamidi Madani","doi":"10.1007/s11255-024-04241-z","DOIUrl":"10.1007/s11255-024-04241-z","url":null,"abstract":"<p><strong>Purpose: </strong>Cardiovascular diseases (CVD) are among the leading causes of death worldwide. Recently, non-classical risk factors for cardiovascular disease, such as lower urinary tract symptoms (LUTS), have gained attention. Both CVD and LUTS are prevalent among aging populations and share common vascular risk factors. The purpose of this study was to investigate the potential relationship between Atherosclerotic Cardiovascular Disease risk and functional bladder capacity among men with LUTS.</p><p><strong>Methods: </strong>This study was conducted on 86 men aged 40-79 with complaints of LUTS who were asked for digital rectal examinations, blood tests on serum total cholesterol and high-density lipoprotein (HDL), and mid-stream urine tests for microscopy and culture. For evaluating patients' LUTS, a 24-h voiding diary was asked. The atherosclerotic cardiovascular diseases (ASCVD) score comprises the patient's current age, sex, race, diabetes mellitus status, smoking status, hypertension status, systolic and diastolic blood pressure, total cholesterol, and HDL levels.</p><p><strong>Results: </strong>According to the ASCVD score, 46 and 40 patients were categorized as low and high risks for cardiovascular diseases, respectively. Based on the FBC, 47 patients had decreased FBC and the rest were normal. According to logistic regression, it was determined that age can be considered a predictive variable for decreased FBC and the lower FBC can be considered as a predictive factor in the high-risk group for cardiovascular diseases (p = 0.002).</p><p><strong>Conclusion: </strong>It seems that decreased FBC is related to a higher predicted cardiovascular event rate in men with LUTS and could be considered a predictor of ASCVD risk.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"709-713"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between serum intact parathyroid hormone and survival in dialysis patients. 透析患者血清完整甲状旁腺激素与存活率之间的关系
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-03-01 Epub Date: 2024-11-18 DOI: 10.1007/s11255-024-04288-y
Chunlei Luo, Xueyan Bian, Chunyang Ji, Hanlu Wang, Jianwei Ma, Chenyu Zhong, Qiang Yu
{"title":"Association between serum intact parathyroid hormone and survival in dialysis patients.","authors":"Chunlei Luo, Xueyan Bian, Chunyang Ji, Hanlu Wang, Jianwei Ma, Chenyu Zhong, Qiang Yu","doi":"10.1007/s11255-024-04288-y","DOIUrl":"10.1007/s11255-024-04288-y","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the relationship between serum intact parathyroid hormone (iPTH) levels and survival in maintenance dialysis patients.</p><p><strong>Methods: </strong>We retrospectively reviewed the data of patients who began and continued dialysis from January 2013 to December 2022. Patients were categorized based on their baseline and time-averaged (TA) iPTH levels into three groups: low (iPTH < 150 pg/ml), medium (150 ≤ iPTH < 300 pg/ml), and high (iPTH ≥ 300 pg/ml). We utilized the Kaplan-Meier method to assess survival differences, the Cox proportional hazards regression model to identify risk factors impacting adverse outcomes and the restricted cubic spline model to evaluate the association between iPTH levels and the all-cause mortality.</p><p><strong>Results: </strong>We included a total of 1023 participants, comprising 524 hemodialysis and 499 peritoneal dialysis. Kaplan-Meier analysis showed that high baseline group had higher survival and low baseline group had poorer survival, compared with medium baseline group, respectively (χ<sup>2</sup> = 44.974, P < 0.001). The three TA groups showed similar results (χ<sup>2</sup> = 67.316, P < 0.001). Multivariate COX regression analysis showed that low TA iPTH was an independent risk factor for all-cause death (hazard ratio [HR] = 1.655, 95% CI 1.159-2.365, P = 0.006). The restricted cubic spline model revealed an L-shaped connection between TA iPTH level and the all-cause mortality with an inflection point of 193 pg/ml.</p><p><strong>Conclusion: </strong>The survival for maintenance dialysis patients varies significantly based on their baseline and time-averaged iPTH levels, with time-averaged iPTH emerges as an independent risk factor for all-cause death in these patients.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1019-1028"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of heart failure and atrial fibrillation on cardiorespiratory fitness in hemodialysis patients. 心力衰竭和心房颤动对血液透析患者心肺功能的影响。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-03-01 Epub Date: 2024-10-28 DOI: 10.1007/s11255-024-04260-w
Eva Pella, Afroditi Boutou, Aristi Boulmpou, Marieta P Theodorakopoulou, Artemios G Karagiannidis, Nasra Haddad, Fotini Iatridi, Ioannis Tsouchnikas, Christodoulos E Papadopoulos, Vassilios Vassilikos, Pantelis A Sarafidis
{"title":"Effect of heart failure and atrial fibrillation on cardiorespiratory fitness in hemodialysis patients.","authors":"Eva Pella, Afroditi Boutou, Aristi Boulmpou, Marieta P Theodorakopoulou, Artemios G Karagiannidis, Nasra Haddad, Fotini Iatridi, Ioannis Tsouchnikas, Christodoulos E Papadopoulos, Vassilios Vassilikos, Pantelis A Sarafidis","doi":"10.1007/s11255-024-04260-w","DOIUrl":"10.1007/s11255-024-04260-w","url":null,"abstract":"<p><strong>Purpose: </strong>Heart failure (HF) and atrial fibrillation (AF) are highly prevalent in hemodialysis. They are well-known significant modifiers of the disease associations with cardiovascular outcomes, but there is a lack of evidence regarding the effects of HF and AF on cardiorespiratory fitness. This study is the first to examine the possible association of the presence of HF and AF with exercise intolerance in patients undergoing hemodialysis.</p><p><strong>Methods: </strong>This analysis included 40 sex- and age-matched participants [10 hemodialysis patients with HF or AF, 10 hemodialysis patients without HF or AF, 10 patients with HF or AF without chronic kidney disease (CKD) and 10 healthy controls] that underwent CPET and spirometry examinations. The total of patients with HF had preserved ejection fraction.</p><p><strong>Results: </strong>VO2peak(ml/kg/min) showed a graded increase between hemodialysis patients with HF or AF, hemodialysis patients without HF or AF, non-CKD patients with HF or AF and controls (13.17 ± 2.45 vs 15.26 ± 3.29 vs 19.64 ± 5.84 vs 25.11 ± 6.94 ml/kg/min, p < 0.001); VO2peak(ml/min) followed the same pattern (1172 ± 197 vs 1269 ± 314 vs 1817 ± 583 vs 1952 ± 592 ml/min respectively, p = 0.001). VO2peak(%predicted), VO2AT(ml/kg/min), VO2AT(ml/min) and maximal work load significantly differed between the study groups, with a tendency for higher values from hemodialysis patients to non-CKD patients with HF or AF and to healthy controls. FEV1 and FVC levels were similar between the study groups. In the whole population, VO2peak(ml/kg/min) showed a positive correlation with hemoglobin (r = 0.663, p < 0.001) and negative correlations with high-sensitivity cardiac troponin I (r = - 0.493, p = 0.001) and BNP (r = - 0.479, p = 0.002).</p><p><strong>Conclusion: </strong>Hemodialysis patients have low exercise tolerance, and the presence of HF or AF is associated with further decreased values of VO2peak, the most important determinant of cardiorespiratory fitness.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"897-906"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive assessment in uro-oncologic geriatric patients: interdisciplinary management to improve survival. 泌尿肿瘤老年患者的综合评估:跨学科管理,提高生存率。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-03-01 Epub Date: 2024-10-29 DOI: 10.1007/s11255-024-04254-8
José Mauricio Ocampo Chaparro, Daniel Andrés Nieva-Posso, Herney Andrés García-Perdomo
{"title":"Comprehensive assessment in uro-oncologic geriatric patients: interdisciplinary management to improve survival.","authors":"José Mauricio Ocampo Chaparro, Daniel Andrés Nieva-Posso, Herney Andrés García-Perdomo","doi":"10.1007/s11255-024-04254-8","DOIUrl":"10.1007/s11255-024-04254-8","url":null,"abstract":"<p><p>Urological cancers represent 13.1% of cancer cases in the world, with a mean age of diagnosis of 67 years, making it a geriatric disease. The lack of participation and evaluation of treatments by the geriatric oncologic population has made their mortality rate higher than that of other oncologic population groups, urologic cancers being no exception. The comprehensive management of older people with urological cancers is a bet that is presented to improve the quality of life and survival of this group. Managing elements such as nutritional, physical, cognitive, psychosocial, and sexual status improves the chances of adherence and treatment, contributing significantly to improving the quality of life. The integrated management of the geriatric oncology population has brought positive effects on quality of life, enhancing levels of depression and anxiety and also allowing the classification of oncology patients based on other criteria in addition to their chronologic age, contributing to the management of specialized treatments that have allowed the implementation of more specific interventions with better results.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"681-690"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uric acid mediates the association between testosterone and α-Klotho among males: results from the NHANES 2013-2016. 尿酸介导男性睾酮与α-Klotho之间的关联:2013-2016年国家健康调查(NHANES)的结果。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-03-01 Epub Date: 2024-11-02 DOI: 10.1007/s11255-024-04262-8
Andong Guo, Jishuang Cao, Chenrui Wu, Sentai Ding
{"title":"Uric acid mediates the association between testosterone and α-Klotho among males: results from the NHANES 2013-2016.","authors":"Andong Guo, Jishuang Cao, Chenrui Wu, Sentai Ding","doi":"10.1007/s11255-024-04262-8","DOIUrl":"10.1007/s11255-024-04262-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study initially conducted a cross-sectional analysis to examine the association between total testosterone (TT), uric acid, and Klotho. The investigation examined whether uric acid mediates the association between TT and Klotho in males.</p><p><strong>Methods: </strong>Based on data from the National Health and Nutrition Examination Survey (NHANES) 2013-2016, this study performed weighted multivariable-adjusted linear regression to evaluate the association between TT, uric acid, and α-Klotho. Then, mediation analysis was conducted to delineate the potential mediating role of uric acid in the TT-Klotho association.</p><p><strong>Results: </strong>Multivariable linear regression analyses revealed inverse relationships between TT and uric acid (β = - 2.75, 95% CI: - 4.21, 1.28, p < 0.001) and between uric acid and α-Klotho (β = - 4.80, 95% CI: - 6.47, - 3.13, p < 0.001). Conversely, a positive correlation existed between TT and α-Klotho (β = 5.38, 95% CI: 2.23, 8.53, p < 0.001). Updated subgroup analyses show that the association strength between α-Klotho, TT, and uric acid levels was consistent across various population settings without significant variations. Restricted cubic spline analysis identified a non-linear association between TT and uric acid with an inflection point at 201 ng/mL. Mediation analysis confirmed uric acid-mediated 18.59% of the association between TT and α-Klotho (p < 0.001), highlighting its significant intermediary role.</p><p><strong>Conclusion: </strong>This study elucidates the complex interrelationship between TT, uric acid, and α-Klotho, highlighting uric acid's significant mediating role. These findings provide novel insights into the hormonal and metabolic mechanisms underlying age-related processes and longevity.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"939-946"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for renal progression in patients with CKD and coexisting COPD. 慢性肾脏病并发慢性阻塞性肺病患者肾功能恶化的风险因素。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-03-01 Epub Date: 2024-10-14 DOI: 10.1007/s11255-024-04227-x
Fan Zhu, Wenyuan Gan, Hui Liu, Wenli Chen, Xingruo Zeng
{"title":"Risk factors for renal progression in patients with CKD and coexisting COPD.","authors":"Fan Zhu, Wenyuan Gan, Hui Liu, Wenli Chen, Xingruo Zeng","doi":"10.1007/s11255-024-04227-x","DOIUrl":"10.1007/s11255-024-04227-x","url":null,"abstract":"<p><strong>Background: </strong>Chronic diseases rarely occur in isolation, and chronic kidney disease (CKD) is no exception. There has been considerable research on the interplay between the heart and kidneys, but studies on the relationship between the lungs and kidneys are less common. The interaction between pulmonary and renal functions in areas such as acid-base metabolism, chronic inflammation, and bone metabolism is increasingly gaining clinical attention.</p><p><strong>Method: </strong>In this cohort study, we examined 480 patients with stages 3-4 CKD and COPD (GOLD stages 1 and 2) to identify risk factors that contribute to the progression of renal function to a composite endpoint, which includes a 40% decline in estimated glomerular filtration rate (eGFR) and the onset of end-stage renal disease during follow-up periods. A Cox proportional hazards regression model was used to investigate the risk factors associated with the timing of renal event endpoints in the study population. Additionally, the restricted cubic spline method was used to explore the relationship between quantitative variables and survival risk.</p><p><strong>Results: </strong>Our study included 480 eligible patients with an average follow-up period of 21.41 ± 14.90 months, during which 224 individuals (46.7%) experienced the composite renal endpoints. Multivariable Cox regression analysis revealed that systolic blood pressure (SBP) [1.01 (1.00-1.02), p = 0.002], hemoglobin (Hb) [HR 0.89 (0.83-0.96), p = 0.002], albumin (Alb) [0.96 (0.93-0.99), p = 0.009], and edema [1.73 (1.29-2.33), p < 0.001] were independent risk factors for the renal endpoints.</p><p><strong>Conclusion: </strong>The adjusted multivariable Cox regression analysis demonstrated that elevated SBP and edema were factors that promoted the occurrence of composite endpoints, while higher levels of Hb and Alb were protective factors.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"885-895"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does combination of urodynamic reduced bladder capacity and detrusor overactivity warrant spinal cord magnetic resonance imaging in children with persistan enuresis: a prospective study. 一项前瞻性研究:尿动力学膀胱容量减少和逼尿肌过度活动是否需要对顽固性遗尿症儿童进行脊髓磁共振成像。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-03-01 Epub Date: 2024-10-23 DOI: 10.1007/s11255-024-04249-5
Mücahit Kart, Engin Doğantekin, Mehmet Ezer, Cüneyd Özkürkçügil
{"title":"Does combination of urodynamic reduced bladder capacity and detrusor overactivity warrant spinal cord magnetic resonance imaging in children with persistan enuresis: a prospective study.","authors":"Mücahit Kart, Engin Doğantekin, Mehmet Ezer, Cüneyd Özkürkçügil","doi":"10.1007/s11255-024-04249-5","DOIUrl":"10.1007/s11255-024-04249-5","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the necessity of spinal cord magnetic resonance imaging (MRI) in children with persistent enuresis, specifically those presenting with urodynamically reduced bladder capacity (RBC) and detrusor overactivity (DO), in comparison to children with normal urodynamic findings.</p><p><strong>Methods: </strong>We evaluated 586 children admitted for bedwetting, all of whom received urotherapy and/or pharmacotherapy. Persistent enuresis, lasting for over one year, was identified in 134 patients who were subsequently re-evaluated for occult neurological conditions and recommended for urodynamic studies (UDS). In total, 92 patients provided informed consent and underwent UDS. Of these, 40 patients were divided into two cohorts based on UDS findings. All patients were over 6 years of age and had normal physical examinations. The first cohort consisted of 23 children RBC and DO, while the second cohort included 17 children with normal UDS findings. All participants underwent spinal cord MRI with a 3 Tesla scanner. Urodynamic and MRI results were compared using Fisher's chi-square test.</p><p><strong>Results: </strong>The median age of the cohort was 11 years, with 26 (65%) of the patients being female. Spinal disorders were identified in 10 patients (25%), with 8 cases of spina bifida without neurological compression and 2 cases of tethered cord. In the RBC + DO cohort, 7 out of 23 patients (30.4%) were found to have spinal disorders, compared to 3 out of 17 patients (17.6%) in the normal UDS cohort, with no statistically significant difference between the groups (p > 0.05).</p><p><strong>Conclusion: </strong>When evaluating persistent enuresis nocturna, a combination of RBC and DO in children with nocturnal enuresis and daytime symptoms may warrant spinal cord MRI, though with limited cost-effectiveness.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"735-740"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142500538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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