International Urology and Nephrology最新文献

{"title":"Effect of resveratrol on the renal cell morphology in acute restraint stress-induced male adult Wistar albino rat model, a pilot study.","authors":"B V Murlimanju, Anusha Anandu Naik, Pooja K Suresh, Y Lakshmisha Rao, Mangala M Pai, Ashwin R Rai, Ramesh Holla","doi":"10.1007/s11255-025-04791-w","DOIUrl":"https://doi.org/10.1007/s11255-025-04791-w","url":null,"abstract":"<p><strong>Purpose: </strong>The goal was to observe the microscopic picture of the kidney in acute restraint stress-induced male adult Wistar albino rat model and to study the beneficial effect of resveratrol (RSV) on it.</p><p><strong>Methods: </strong>The rats were divided into three groups of six animals each, including control, experimental, and treatment groups. Stress was induced by keeping the rats immobilized in a rigid opaque plastic cylinder for 2 weeks, which restrained their movements. The treatment group received RSV orally 10 mg/kg body weight for two more weeks after the initial 2-week period of stress induction. The EGTI scoring system was considered to assess the renal injury.</p><p><strong>Results: </strong>The kidneys of the stress-induced group exhibited congested and swollen glomeruli, increased cellularity, basement membrane thickness, and glomerular tuft retraction. There were interstitial edema, glomeruli puckering, and the Bowman's space extension. Renal tubules showed hyaline casts, granular degeneration, loss of brush border, and necrosis. Blood vessels were thickened, and the lumens were occluded. A few locations also revealed congested and dilated blood vessels. Interstitium showed focal aggregates of acute and chronic inflammation. Due to the stress, the EGTI renal injury score was seven (7/14). The treatment group revealed reversal of pathological changes observed at the glomerulus and convoluted tubules.</p><p><strong>Conclusion: </strong>According to this study, RSV appears to be nephroprotective as it reversed most of the pathological changes induced by the acute restraint stress. However, the treatment with RSV followed the withdrawal of stress which is a potential limitation of this study design. A better conclusion can be drawn if RSV and stress are parallelly administered.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acidosis risk and methodological considerations in overnight-dwelled amino acid peritoneal dialysis.","authors":"Muhammad Nabeel Saddique, Muhamad Huzaifa Khalil","doi":"10.1007/s11255-025-04792-9","DOIUrl":"https://doi.org/10.1007/s11255-025-04792-9","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study on the prevention of iodinated contrast-induced kidney injury in rats by tetramethylpyrazine and the detection of their renal function by intravoxel incoherent motion.","authors":"Xiao Yu Song, Jin Long Chen, Zhi Qiang Wang","doi":"10.1007/s11255-025-04790-x","DOIUrl":"https://doi.org/10.1007/s11255-025-04790-x","url":null,"abstract":"<p><strong>Purpose: </strong>Experimental study on tetramethylpyrazine (TMP) for preventing contrast-induced renal injury in rats using magnetic resonance intravoxel incoherent motion (IVIM) to assess renal water diffusion properties and perfusion.</p><p><strong>Methods: </strong>Eighty-four Sprague-Dawley(SD) male rats were divided into four groups: control (saline), CI-AKI (iohexol 2.5 g I/kg), CI-AKI + TMP (iohexol2.5 g I/kg + 80 mg/kg TMP), and CI-AKI + saline. The IVIM images were acquired longitudinally at baseline and 1, 24, 48, and 72 h after the administration of the drugs to evaluate the apparent diffusion coefficient (ADC), pure diffusion coefficient (D), perfusion-related value (D*), and perfusion fraction (f) values. Serum creatinine (SCR), histology, and hypoxia-inducible factor-1α (HIF-1α) immunoexpression were determined.</p><p><strong>Results: </strong>In the control group, there were no significant changes in ADC, D, D*, and f values of renal cortex (CO), outer medulla (OM), and inner medulla (IM) at all time points. In the CI-AKI group, ADC, D, D*, and f values of renal CO, OM, and IM reached the lowest level at 48 h (p < 0.05). In the CI-AKI + TMP group, the ADC, D, D*, and f values of renal CO, OM, and IM were significantly higher than those of the CI-AKI group at 48 h and 72 h. In particular, these values returned to baseline levels by 72 h. No improvement was observed in the CI-AKI + saline group. ADC, D, D *, and f values negatively correlated with renal injury score (all p < 0.001, r = -0.845 to 0.913) and HIF-1α expression (all p < 0.001, r = -0.846 to 0.920).</p><p><strong>Conclusion: </strong>TMP prevents early contrast-induced renal injury and allows noninvasive detection of renal water diffusion properties and perfusion function by IVIM.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"critical appraisal of metformin's nephroprotective role in cisplatin therapy: need for rigorous validation\".","authors":"Samah E Mahran, Salem Eid Salem, Nirmeen A Sabry, Samar F Farid","doi":"10.1007/s11255-025-04787-6","DOIUrl":"https://doi.org/10.1007/s11255-025-04787-6","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical insights on \"Association between hemoglobin glycation index and carotid plaques in non-dialysis CKD stage 3-5 patients: a retrospective cross-sectional study\".","authors":"Jiaxin Shao, Caifeng Zhu, Jiazhen Yin","doi":"10.1007/s11255-025-04789-4","DOIUrl":"https://doi.org/10.1007/s11255-025-04789-4","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicolegal landscape of prostate cancer ablative therapy: a national legal database analysis of malpractice claims (1970-2024).","authors":"Boyuan Xiao, Zhiyu Qian, Andrea Piccolini, Filippo Dagnino, Stephan M Korn, Hanna Zurl, Klara K Pohl, Daniel R Stelzl, Caroline M Moore, Daniel Wollin, Quoc-Dien Trinh, Alexander P Cole","doi":"10.1007/s11255-025-04766-x","DOIUrl":"https://doi.org/10.1007/s11255-025-04766-x","url":null,"abstract":"<p><strong>Background: </strong>With the advancement of MR-based imaging, prostate cancer ablative therapies have seen increased interest to reduce complications of prostate cancer treatment. Although less invasive, they do carry procedural risks, including rectal injury. To date, the medicolegal aspects of ablative therapy remain underexplored. In this study, we aim to analyze malpractice lawsuits related to prostate cancer ablative therapies using a national legal database.</p><p><strong>Methods: </strong>In this retrospective study, we utilized the LexisNexis Database to analyze ablative therapy malpractice lawsuits between 1970 and 2024. We searched for keywords \"ablative therapy\" \"focal therapy\" \"high-intensity focused ultrasound\" \"HIFU\" \"cryotherapy\" \"cryoablation\" \"laser\" \"irreversible electroporation\" and \"IRE\" We excluded cases that did not involve ablative treatment of prostate cancer. We then reviewed cases for treatment method, allegation, claimed liabilities, verdict, and plaintiff award.</p><p><strong>Results: </strong>We identified 180 lawsuits using the keywords provided, and 5 cases met inclusion criteria. All five lawsuits involved cryoablation for prostate cancer. The most common precipitating injury was rectal injury (3, 60%). Allegations included negligence (2, 25%), deviation from the standard of care (2, 25%), deliberate indifference (2, 25%), and failure to consent (2, 25%). Verdicts were predominantly favorable to defendants (4, 80%), and one case (20%) resulted in an unknown outcome.</p><p><strong>Conclusions: </strong>Ablative therapy had a limited number of lawsuits, with outcomes favorable to surgeons and minimal financial payouts. As ablative therapy continues to gain popularity, urologists must practice proper surgical techniques, conduct thorough informed consent, and exercise excellent patient-provider communication to help minimize the occurrence and impact of litigations involving ablative therapy. These findings may help guide future patient risk counseling and support adjustments in malpractice insurance policies as the use of ablative therapies expands, while also informing physicians and hospital systems considering their adoption or expansion.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of donor kidney function in living-related kidney transplant: observation from a single centre with 18 year experience in Malaysia.","authors":"Norshuhada Amat, Jeffery Lim, Muhammad Solihin Rezali, Kanesh Seevalingam, Ahmad N Fadzli, Norman Dublin, Azad Razack, Teng Aik Ong, Shanggar Kuppusamy","doi":"10.1007/s11255-025-04725-6","DOIUrl":"https://doi.org/10.1007/s11255-025-04725-6","url":null,"abstract":"<p><strong>Purpose: </strong>Living donor kidney transplantation is a critical strategy to address the growing burden of end-stage kidney disease (ESKD) in Malaysia. Whilst living donation is generally safe, concerns remain regarding long-term donor outcomes. This study aimed to evaluate renal function and morbidity changes in living kidney donors 1 year post-donation, and to identify predictors of impaired kidney function.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using clinical records of 230 living kidney donors who underwent nephrectomy at University Malaya Medical Centre between 2003 and 2021. Donor sociodemographic characteristics, comorbidities, and estimated glomerular filtration rate (eGFR) were assessed pre-donation and at 1 year post-donation. Impaired kidney function was defined as eGFR < 90 mL/min/1.73m². Data were analysed using descriptive statistics and multivariate logistic regression.</p><p><strong>Results: </strong>At 1 year post-donation, 76.2% of donors exhibited impaired kidney function. Additionally, the proportion of donors with diabetes and dyslipidaemia increased significantly post-donation. Male sex and increasing age were significant predictors of reduced eGFR. Ethnic Chinese and 'Others' ethnicities were found to have a lower risk of impaired renal function compared to Malays. No significant association was found between baseline comorbidity status and post-donation eGFR.</p><p><strong>Conclusion: </strong>The study highlights the importance of age, gender, and ethnicity in predicting renal outcomes post-donation. These findings underscore the need for standardised pre-donation screening and structured post-donation surveillance. Strengthening clinical protocols and policy frameworks is essential to ensure donor safety and the sustainability of living donor transplantation in Malaysia.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Exploring the influencing factors of abdominal aortic calcification events in chronic kidney disease (CKD) and non-CKD patients based on interpretable machine learning methods.","authors":"Sanjeet Kumar, Alfa Almani, Adarsh Shahani, Aveena Lohana, Sadia Siddique, Ali Karim","doi":"10.1007/s11255-025-04778-7","DOIUrl":"https://doi.org/10.1007/s11255-025-04778-7","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finerenone in type 1 diabetes and chronic kidney disease: short-term efficacy and safety insights.","authors":"Dandan Qiu, Jingjing Wang, Aijuan Li, Wei Zhang, Xiaofeng Du, Genwang Wang, Song Jiang","doi":"10.1007/s11255-025-04773-y","DOIUrl":"https://doi.org/10.1007/s11255-025-04773-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the short-term efficacy and safety of finerenone in patients with type 1 diabetes (T1D) and chronic kidney disease (CKD).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on a relatively small sample of 23 patients diagnosed with T1D and CKD between January 2023 and August 2024. All patients received renin-angiotensin system inhibitors (RASi), with 12 patients additionally treated with finerenone.</p><p><strong>Results: </strong>The cohort had a median age of 34 (29, 39) years, including 11 females. Median Hemoglobin A1c (HbA1c) was 7.30% (6.55, 8.10%), proteinuria was 1.49 (0.88, 2.84) g/24h, mean estimated glomerular filtration rate (eGFR) was 71.91 ± 24.59 mL/min/1.73m², and serum potassium was 4.47 ± 0.39 mmol/L. After 6 months of follow-up, eGFR declined significantly in the control group (- 10.55 ± 14.61 mL/min/1.73m², P = 0.038) but remained stable in the finerenone group (- 1.34 ± 11.98 mL/min/1.73m², P = 0.706). No significant changes were observed in proteinuria, serum potassium, blood pressure, or other metabolic parameters in either group. No cases of hyperkalemia or acute kidney injury (AKI) were observed among patients who completed the 6-month follow-up.</p><p><strong>Conclusion: </strong>In this preliminary study, finerenone showed potential for attenuating kidney function decline in patients with T1D and CKD, though its long-term efficacy and safety require validation in larger trials.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate MR image segmentation using a multi-stage network approach.","authors":"Lars E O Jacobson, Mohamed Bader-El-Den, Lalit Maurya, Adrian A Hopgood, Vincenzo Tamma, Shamsul K Masum, David J Prendergast, Peter Osborn","doi":"10.1007/s11255-025-04763-0","DOIUrl":"https://doi.org/10.1007/s11255-025-04763-0","url":null,"abstract":"<p><p>Prostate cancer (PCa) remains one of the most prevalent cancers among men, with over 1.4 million new cases and 375,304 deaths reported globally in 2020. Current diagnostic approaches, such as prostate-specific antigen (PSA) testing and trans-rectal ultrasound (TRUS)-guided biopsies, are often Limited by low specificity and accuracy. This study addresses these Limitations by leveraging deep learning-based image segmentation techniques on a dataset comprising 61,119 T2-weighted MR images from 1151 patients to enhance PCa detection and characterisation. A multi-stage segmentation approach, including one-stage, sequential two-stage, and end-to-end two-stage methods, was evaluated using various deep learning architectures. The MultiResUNet model, integrated into a multi-stage segmentation framework, demonstrated significant improvements in delineating prostate boundaries. The study utilised a dataset of over 61,000 T2-weighted magnetic resonance (MR) images from more than 1100 patients, employing three distinct segmentation strategies: one-stage, sequential two-stage, and end-to-end two-stage methods. The end-to-end approach, leveraging shared feature representations, consistently outperformed other methods, underscoring its effectiveness in enhancing diagnostic accuracy. These findings highlight the potential of advanced deep learning architectures in streamlining prostate cancer detection and treatment planning. Future work will focus on further optimisation of the models and assessing their generalisability to diverse medical imaging contexts.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}