International Urology and Nephrology最新文献

{"title":"Cognitive frailty in maintenance hemodialysis: a scoping review.","authors":"Kai Zhang, Shuimiao Wei, Ruixue Wang, Ailing Li, Nan Zhang, Cuiping Ni","doi":"10.1007/s11255-025-04361-0","DOIUrl":"10.1007/s11255-025-04361-0","url":null,"abstract":"<p><strong>Purpose: </strong>To conduct a scoping review of the related research on cognitive frailty (CF) in maintenance hemodialysis (MHD) patients, so as to provide a basis for early diagnosis, treatment and intervention of CF in MHD patients.</p><p><strong>Methods: </strong>Utilizing a scoping review approach, we searched PubMed, Embase, The Cochrane Library, Web of Science, CINAHL, the China Biological Medicine Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang, and Weipu (VIP) for literature on CF in MHD patients up to October 20, 2024. Two researchers conducted independent screening and data extraction of the literature's fundamental characteristics. The study is registered in OSF ( https://doi.org/10.17605/OSF.IO/H6Q89 ).</p><p><strong>Results: </strong>The review included 21 articles, revealing a concerningly high prevalence of CF in MHD patients, ranging from 4.6 to 56.4%. Six diagnostic combinations were identified, with the combination of Frailty Phenotype (FP), Montreal Cognitive Assessment (MOCA), and Clinical Dementia Rating (CDR) scales being the most prevalent. Influencing factors were categorized into demographic and lifestyle, physical condition, disease-related and psychosocial aspects. Interventions included exercise, cognitive therapy combined with exercise, social support and predictive nursing, yet there remains a scarcity of intervention studies.</p><p><strong>Conclusion: </strong>The prevalence of CF in MHD patients is high; however, understanding of CF in MHD patients is insufficient. There are many types of assessment tools, but there is a lack of unified standards and specificity; the influencing factors are complex and diverse; and prevention and intervention studies are scarce.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2159-2169"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of radiation exposure for interventional radiology vs urology-guided renal access for percutaneous nephrolithotomy.","authors":"Dar Yoffe, Sarah Fashakin, Kenneth Lim, Daniel Marchalik","doi":"10.1007/s11255-025-04374-9","DOIUrl":"10.1007/s11255-025-04374-9","url":null,"abstract":"<p><strong>Introduction: </strong>Radiation exposure during percutaneous nephrolithotomy (PCNL) can vary depending on the method used for renal access. This study aimed to compare fluoroscopy time and dose during PCNL when renal access is achieved via interventional radiology (IR) versus urology.</p><p><strong>Methods: </strong>A retrospective review of patients who underwent unilateral PCNL between January 2020 and February 2023 was conducted. Patients were categorized by renal access method: endoscopic combined intrarenal surgery performed by a urologist (ECIRS) or IR-assisted. A Wilcoxon rank-sum test and multivariate analyses were done to compare several parameters of the two groups.</p><p><strong>Results: </strong>66 patients underwent ECIRS (group 1), and 31 underwent IR-assisted access (group 2). The groups were similar in age, BMI, sex, and stone size. The difference in medians for fluoroscopy dose, fluoroscopy time, operative time and length of stay were statistically significant (p < 0.001). Average fluoroscopy dose (39.6 vs. 327 mGy) and time (1.46 vs. 10.9 min), along with average operative time (1.97 vs. 3.00 h) and length of stay (1.26 vs 3.06 days) were all lower in group 1. In the IR group, a positive correlation was noted between BMI and fluoroscopy dose (p < 0.001), though this correlation was absent with ECIRS.</p><p><strong>Conclusions: </strong>PCNL with ECIRS access significantly reduces radiation exposure and operative time compared to IR-assisted access. Additionally, BMI influenced radiation exposure and operative time in the IR group, but not in the ECIRS group. Endoscopic renal access may lower overall radiation exposure and postoperative complications.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2057-2061"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of hydronephrosis on shockwave lithotripsy outcomes for upper ureteral stones.","authors":"Mubariz Aydamirov, Kadir Karkin, Bugra Aksay, Ediz Vuruskan, Muslum Ahmet Tunckiran","doi":"10.1007/s11255-025-04376-7","DOIUrl":"10.1007/s11255-025-04376-7","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of the degree of hydronephrosis on extracorporeal shockwave lithotripsy (SWL) success in patients who underwent SWL due to upper ureteral stones.</p><p><strong>Methods: </strong>Medical records of 878 patients who underwent SWL were retrospectively reviewed. Patients with isolated unilateral 6-10 mm radiopaque upper ureteral stones above the upper border of the sacroiliac joint were included in the study. The primary endpoint of the study was the relationship between the degree of hydronephrosis with upper ureteral stones and the stone clearance time, number of SWL sessions, and success, while the secondary endpoint was the effect of the presence of severe hydronephrosis (SFU grade 3) on SWL success.</p><p><strong>Results: </strong>The mean age of the patients was 41.3 ± 10.9 years. The mean stone size was 8.2 (6-10) mm. Ureteropelvic junction stones were present in 24 (20%) patients. The mean stone clearance time was 14.6 ± 9.7 days. One-month SWL success was determined as 85%. SWL success rates decreased as the degree of hydronephrosis increased (p = 0.047). Being 45 years of age and older increased the risk of SWL failure by 16.25 times (OR = 16.25, p = 0.017). Increasing the stone clearance time by 1 day increased the risk of SWL failure by 1.17 times (OR = 1.17, p = 0.006), and increasing the number of SWL sessions by 1 session increased the risk of SWL failure by 7.69 times (OR = 7.69, p = 0.016). The presence of severe hydronephrosis (grade 3) did not affect SWL success (OR = 5.56, p = 0.071).</p><p><strong>Conclusion: </strong>According to our study results, as the degree of hydronephrosis increases in 6-10 mm upper ureteral stones, the number of SWL sessions increases, stone expulsion times prolong, and 1-month success rates decrease.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2041-2046"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary metabolomics analysis of patients with renal tubular dysfunction after PCI surgery.","authors":"Wenwen Huang, Xinxin Chen, Xiaoyan Xu, Shufang Pan","doi":"10.1007/s11255-025-04397-2","DOIUrl":"10.1007/s11255-025-04397-2","url":null,"abstract":"<p><strong>Purpose: </strong>Differences in metabolic profiles were used to search for urinary metabolic markers in patients with tubular dysfunction after percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>In this study, 50 patients with renal tubule dysfunction 6 h after PCI were collected and urine samples before PCI were used as control group and 6 h after PCI were used as observation group. The urine samples were processed by high-speed centrifugation, filtered by microporous membrane, and the superclear was obtained for LC-MS detection and analysis, and their metabolic profiles and related data were obtained.</p><p><strong>Results: </strong>Compared with the control group, α1-MG, NAG and Cys-C in the urine of the observation group were significantly increased, and the difference was statistically significant (P < 0.05). After the urine samples were processed by LC-MS technology, SIMCA realized the visual visualization of the score plots of PCA, OPLS-DA and other models, and then verified by statistical methods, it was found that there were different metabolites in the urine of patients before and after PCI. The HMDB database was used to search for differential metabolites and 16 different metabolites such as L-ornithine, oleic acid amide, D-histidine, p-hydroxyphenyllactic acid, acetylmethionine, N-(2-furanyl) glycine, cholesterol laurate, cholic acid, 1-methylguanine, L-hydrochloric acid, homovanillic acid, alpha-keto-isocaproic acid, 3-β-hydroxy-D5-cholenoic acid, adenine, palmitic acid, pentadecanoic acid. Pathway Analysis in MetaboAnalyst5.0 was used to analyze the metabolic pathways of 16 different metabolites. Finally, a total of 11 metabolic pathways were matched. Finally, we believe that the biosynthetic pathway of arginine and the metabolic pathway of alanine, aspartate and glutamate are most relevant to tubular dysfunction after percutaneous coronary intervention (PCI).</p><p><strong>Conclusion: </strong>In this study, LC-MS technology was used to analyze urine samples from CIN patients and patients with coronary heart disease before and after PCI and a total of 16 different metabolites were screened out, which may serve as potential biomarkers to help diagnose renal tubular dysfunction. There are 11 metabolic pathways in the body involved in the occurrence and development of renal tubular dysfunction after angiography and the biosynthesis pathway of arginine and the metabolic pathway of alanine, aspartate and glutamate may play the most important role in the occurrence and development of renal tubular dysfunction.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2237-2244"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors in T1 high-grade urothelial carcinoma of the bladder with lymphovascular invasion: a retrospective cohort study.","authors":"Yajun Li, Xiaoyu Sun, Yue Wang, Baojie Ma, Changyi Quan","doi":"10.1007/s11255-025-04391-8","DOIUrl":"10.1007/s11255-025-04391-8","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the long-term treatment outcomes of T1 high-grade (T1HG) urothelial carcinoma (UCB) with lymphovascular invasion (LVI).</p><p><strong>Methods: </strong>We retrospectively analyzed the data of 70 patients of T1HG UCB with LVI who were treated at the Second Hospital of Tianjin Medical University between 2009 and 2019. The log rank test and Cox regression analyses were performed to identify factors that predict the recurrence and survival of these \"highest risk\" group of non-muscle invasive bladder cancer (NMIBC).</p><p><strong>Results: </strong>With a median follow-up of 46.0 months (range 2-151), the 5-year overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS) and progression-free survival (PFS) rates were 65%, 78%, 28% and 56% after trans-urethral resection of bladder tumor (TURBT), and 35%, 48%, 35% and 35% after radical cystectomy (RC), respectively. Treatment modality (tumor burden) was and independent predictor of OS (Hazard ratios (HRs) 2.176, 95% confidence intervals (CIs) 1.021-4.637, p = 0.044) and CSS (HRs 3.675, CIs 1.311-10.297, p = 0.013), and was weakly associated with RFS (HRs 0.560, CIs 0.281-1.114, p = 0.099). A history of urothelial carcinoma of the bladder (H.UCB) was an independent predictor of RFS (HRs 2.246, CIs 1.102-4.579, p = 0.026) and PFS (HRs 2.259, CIs 1.036-4.927, p = 0.041). Tumor size was an independent predictor of RFS (HRs 2.093, CIs 1.054-4.159, p = 0.035).</p><p><strong>Conclusions: </strong>In T1HG UCB with LVI, tumor burden was a significant predictor of survival. Radical cystectomy should be individualized and not universally recommended. Recurrent T1HG UCB with LVI potentially represents a sign of progression, and RC regardless of tumor burden might be a reasonable alternative for this subgroup of patients.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2099-2105"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling interrelationships through structural equation modeling: family function, social networks, and social phobia in peritoneal dialysis patients.","authors":"Zongbi Wu, Yuxin Yan, Huifang Cai, Shikun Qi, Mingming Xu, Taifen Wang, Youli Jiang","doi":"10.1007/s11255-025-04396-3","DOIUrl":"10.1007/s11255-025-04396-3","url":null,"abstract":"<p><strong>Background: </strong>Peritoneal dialysis (PD) enhances quality of life for end-stage renal disease patients, however, family function, social networks, and social phobia may significantly influence patient outcomes. This study explores the interrelationships among these factors in a Chinese population of PD patients, considering the socio-cultural context of Shenzhen as an immigrant city.</p><p><strong>Methods: </strong>This cross-sectional study included 259 PD patients from Shenzhen Traditional Chinese Medicine Hospital, recruited between December 2023 and April 2024. Participants completed validated questionnaires assessing family function (Family APGAR), social networks (LSNS-6), and social phobia (SASS-CS). Data were analyzed using Spearman correlation and Structural Equation Modeling (SEM) to examine direct and indirect relationships among the variables.</p><p><strong>Results: </strong>Most participants demonstrated moderate to high family function. Social network scores positively correlated with family function (r = 0.46, P < 0.001), while family function negatively correlated with social phobia (r = -0.48, P < 0.05). SEM revealed that family function partially mediated the relationship between social networks and social phobia, accounting for 42.1% of the total effect. Good model fit indices were observed (χ²(32) = 48.23, P = 0.042; RMSEA = 0.045; CFI = 0.978; TLI = 0.970).</p><p><strong>Conclusion: </strong>This study underscores the critical role of social networks in supporting family function and reducing social phobia in PD patients. Interventions aimed at strengthening social networks and addressing social phobia could improve family dynamics and patient outcomes.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2291-2300"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global epidemiology of HIV among dialysis patients: a systematic review and meta-analysis.","authors":"Shahad Saif Khandker, Safrin Jahan, Adiba Ayesha Khan, Begum Faijunnesa Abrittee, Rifah Nanjiba, Dewan Zubaer Islam, Ehsan Suez, Md Habibur Rahman, Farha Farahim, Talat Ali, Rahima Begum","doi":"10.1007/s11255-025-04421-5","DOIUrl":"10.1007/s11255-025-04421-5","url":null,"abstract":"<p><p>HIV transmission and infection among dialysis patients have become a major healthcare concern and a rising threat throughout the world. Our current systematic review and meta-analysis targeted to determine the global epidemiologic state of HIV infection among dialysis patients. Three online databases: Google Scholar, PubMed, and ScienceDirect were searched for eligible studies using specific keywords. 15 studies matched our eligibility criteria and were included in the study. The worldwide pooled prevalence of HIV among dialysis patients was 0.8% (95% CI 0.4 to 1.2) with a high degree of heterogeneity (95%) among the included studies. Substantial variations in pooled prevalence were found among different continents in our subgroup analysis. Africa (21.1%, 95% CI 6.4 to 35.8) and North America (19.3%, 95% CI 0.0 to 39.8) had a higher prevalence of HIV in dialysis patients whereas in Europe (0.3%, 95% CI 0.0 to 0.6), South America (0.7%, 95% CI 0.0 to 1.6) and Asia (0.7%, 95% CI 0.0 to 1.6) the frequency was much lower. Perhaps, due to the lack of awareness and preventive knowledge, insufficient healthcare facilities and breaches in infection control protocols in dialysis centers, risky attitudes and practices immigration issues the prevalence of HIV among dialysis patients in Africa and North America enhanced as compared to that of Europe, Asia and South America. Strict adherence to HIV preventive practices, raising public awareness, and advanced healthcare systems are suggested to reduce the prevalence of HIV among dialysis patients all over the world.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2209-2226"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: \"Microbiology and risk factors for bacteremic urinary tract infection: insights from the largest urological center in Pakistan\".","authors":"Syeda Samia Fatima, Kainat Mehmood, Areeba Abid, Hiba Abid","doi":"10.1007/s11255-025-04390-9","DOIUrl":"10.1007/s11255-025-04390-9","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2153-2154"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Re: Low-frequency bladder vibration for the treatment of urinary tract infections in spinal cord injury patients with neurogenic bladder by Zhang et al.","authors":"Chike J Okeke, Shahid Siddique, Rauf N Khadr, Michael S Floyd","doi":"10.1007/s11255-025-04393-6","DOIUrl":"10.1007/s11255-025-04393-6","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2155-2156"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel risk-predicted nomogram for acute kidney injury progression in decompensated cirrhosis: a double-center study in Vietnam.","authors":"Nghia N Nguyen, Bao T Nguyen, Thuy D T Nguyen, Tam T T Tran, Tan N H Mai, Huyen N T Le, Hoang N Dang, Vy B N Nguyen, Nhi Y T Ngo, Cuong T Vo","doi":"10.1007/s11255-025-04398-1","DOIUrl":"10.1007/s11255-025-04398-1","url":null,"abstract":"<p><strong>Objectives: </strong>Acute kidney injury (AKI) is commonly encountered in patients hospitalized for decompensated cirrhosis and is associated with prolonged hospital stays, increased treatment burden, and even mortality. The present study aimed to determine the prevalence of and develop a predictive nomogram for AKI in patients with decompensated cirrhosis.</p><p><strong>Methods: </strong>This cross-sectional, double-center study involved 544 patients hospitalized with decompensated cirrhosis. Acute kidney injury was diagnosed using American Gastroenterological Association's guidelines with one more criterion: an increase in serum creatinine ≥ 0.3 mg/dL within 48 h or an increase in serum creatinine ≥ 50% compared to baseline serum creatinine or when the urine output is reduced below 0.5 mL/kg/h for > 6 h. We used the Bayesian model averaging method find the optimal model for predicting AKI. A predictive nomogram was also developed to enable risk prediction.</p><p><strong>Results: </strong>The overall AKI prevalence was 26.7% (95% Confidence interval [CI] 25.7-27.7). The optimal model for predicting AKI included diuretic therapy (odds ratio [OR]: 5.55; 95%CI 3.31-9.33), infection (OR: 2.06; 95%CI 1.31-3.22), ascites (OR: 3.20; 95%CT: 1.67-6.13), Child-Pugh group C (OR: 2.91; 95%CI 1.84-4.62), serum potassium (OR per 1 mmol/L increase: 1.62; 95%CI 1.25-2.1) and serum chloride (OR per 1 mmol/L decrease: 1.03; 95%CI 1.01-1.06). The area under the receiver operating characteristic curve was 0.8, with a 95%CI ranging from 0.75 to 0.84.</p><p><strong>Conclusions: </strong>Acute kidney injury was relatively common among patients hospitalized for decompensated cirrhosis. A novel nomogram-including diuretic therapy, infection, ascites, Child-Pugh group C, serum potassium and, serum chloride, was helpful for the selective screening of AKI in patients with decompensated cirrhosis.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2279-2290"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}