International Urology and Nephrology最新文献

{"title":"Improving search strategies in bibliometric studies on machine learning in renal medicine.","authors":"Hao-Han Rao, Feng Guo, Jie Tian","doi":"10.1007/s11255-024-04335-8","DOIUrl":"10.1007/s11255-024-04335-8","url":null,"abstract":"<p><p>This paper evaluated the bibliometric study by Li et al. (Int Urol Nephrol, 2024) on machine learning in renal medicine. Although the study claims to summarize the forefront trends and hotspots in this field, several key issues require further clarification to effectively guide future research. Firstly, while the authors used the \"*\" wildcard to broaden the search scope, they screened articles only by document type and language, without specific filtering based on titles, abstracts, or full texts. This approach may have led to the inclusion of irrelevant studies, potentially compromising analytical accuracy. Secondly, the authors conducted the search using the Topic (TS) field, which may include articles not closely related to the intended topic. We recommend using Title (TI), Abstract (AB), and Author Keywords (AK) as filtering criteria in future studies to improve search precision. Finally, in the keyword co-occurrence analysis, the authors did not merge synonyms, leading to distortions in keyword frequency rankings; for example, \"machine learning\" and \"machine learning (ML)\" were treated as separate terms. We believe that synonym merging would enhance the accuracy of keyword analysis. Overall, the search strategy by Li et al. demonstrates issues such as imprecise scope and lack of synonym integration. To ensure the comprehensiveness and accuracy of future research, we suggest refining the search strategy, employing precise screening steps, and integrating synonyms to improve the quality of bibliometric studies.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1987-1988"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of finerenone in membranous nephropathy patients: a retrospective, real‑world study.","authors":"Haowen Lin, Qingqing Gao, Yuhe Yin, Siqi Peng, Xiaoying Dong, Zewen Zhao, Renwei Huang, Yiming Tao, Sichun Wen, Bohou Li, Qiong Wu, Sijia Li, Ting Lin, Hao Dai, Feng Wen, Zhuo Li, Lixia Xu, Jianchao Ma, Zhonglin Feng, Xiaoyan Bai, Shuangxin Liu","doi":"10.1007/s11255-025-04381-w","DOIUrl":"10.1007/s11255-025-04381-w","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to conduct a retrospective analysis to assess the efficacy and safety of finerenone in patients with membranous nephropathy (MN).</p><p><strong>Methods: </strong>This study conducted a retrospective analysis of patients with MN who were treated with finerenone for follow-up period ranging from 3 to 6 months. The study compared the estimated glomerular filtration rate (eGFR), urine total protein-to-creatinine ratio (PCR), urine albumin-to-creatinine ratio (ACR), serum creatinine concentration (SCr), blood pressure and serum potassium (K+) during the follow-up period.</p><p><strong>Result: </strong>In this study, 20 patients with MN were treated with finerenone for a follow-up period of 3 to 6 months. Prior to treatment, the average eGFR was 65.15 mL/min/1.73 m², the average PCR was 3643.63 mg/g, and the average ACR was 2489.44 mg/g. After 3 months of treatment, 80% of patients experienced a decrease in PCR. The median decrease percentages in PCR and ACR are 24.49% and 28.82%, respectively. After 6 months of treatment, the median decrease percentages in PCR and ACR are 42.03% and 43.66%, respectively while the eGFR remained stable with little variation from baseline. During the treatment period, there were minimal changes in serum potassium levels and serum creatinine levels and no treatment discontinuations or hospitalizations due to hyperkalemia were observed. Blood pressure decreased by about 10 mmHg in 6 patients (30%), while there was no difference before and after the addition of finerenone in the remaining 14 (70%) patients.</p><p><strong>Conclusion: </strong>The retrospective analysis indicates that finerenone treatment led to significant reductions in PCR and ACR in patients with membranous nephropathy over a 3 to 6-month period, with minimal impact on eGFR, SCr, and K+ levels, highlighting its capacity as a therapeutic option for MN patient group.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1945-1953"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling diabetic kidney disease: insights from single-cell RNA sequencing.","authors":"Xiao-Lin Yuan, Bei-Bei Lu, Li Zeng, Ling Zhong","doi":"10.1007/s11255-025-04362-z","DOIUrl":"10.1007/s11255-025-04362-z","url":null,"abstract":"<p><p>The incidence of diabetic kidney disease (DKD) is rising annually. Diabetes leads to structural damage and dysfunction in the kidneys, clinically manifesting as progressive proteinuria and declining renal function, ultimately resulting in end-stage renal disease (ESRD). Recent findings have identified a subset of DKD known as normoalbuminuric diabetic kidney disease (NADKD), characterized by normal urine albumin levels but reduced renal function. These complex clinical presentations and underlying pathophysiology challenge traditional diagnostic and treatment approaches. Single-cell RNA sequencing (scRNA-seq), a novel experimental technique, is employed to analyze gene expression in renal tissue, blood, and urine from DKD patients, enhancing our understanding of tissue function, cellular interactions, and disease progression. This approach facilitates early screening and personalized management of DKD.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1885-1893"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting intermediate-risk prostate cancer using machine learning.","authors":"Miroslav Stojadinovic, Milorad Stojadinovic, Slobodan Jankovic","doi":"10.1007/s11255-024-04342-9","DOIUrl":"10.1007/s11255-024-04342-9","url":null,"abstract":"<p><strong>Purposes: </strong>Intermediate-risk prostate cancer (IR PCa) is the most common risk group for localized prostate cancer. This study aimed to develop a machine learning (ML) model that utilizes biopsy predictors to estimate the probability of IR PCa and assess its performance compared to the traditional clinical model.</p><p><strong>Methods: </strong>Between January 2017 and December 2022, patients with prostate-specific antigen (PSA) values of ≤ 20 ng/mL underwent transrectal ultrasonography-guided prostate biopsies. Patient's age, PSA, digital rectal exam, prostate volume, PSA density (PSAD), and previous negative biopsy, number of positive cores, Gleason score, and biopsy outcome were recorded. Patients are categorized into no cancer, very low, low-, and intermediate-risk categories. The relationship between the model and IR PCa was investigated using binary generalized linear model (GLM) and assessed its discriminatory ability by calculating the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Among 729 patients, PCa was detected in 234 individuals (32.1%), with 120 (16.5%) diagnosed with IR PCa. The AUC for the novel model compared to the clinical model was 0.806 (95% CI: 0.722-0.889) versus 0.669 (95% CI: 0.543-0.790), with a p-value of 0.018. In DCA, the GLM outperformed the clinical model by over 7%, potentially allowing for an additional 44.3% reduction in unnecessary biopsies. The PSAD emerged as the most significant predictor.</p><p><strong>Conclusion: </strong>We developed a GLM utilizing pre-biopsy features to predict IR PCa. The model demonstrated good discrimination and clinical applicability, which could assist urologists in determining the necessity of a prostate biopsy.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1737-1746"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of risk factors associated with epicardial fat tissue thickness in patients with stage 4 and stage 5 chronic kidney disease.","authors":"Hasan İnce, Zülfükar Yılmaz, Aziz Karabulut, Emre Aydın, Yaşar Yıldırım, Ali Veysel Kara, Ali Kemal Kadiroğlu, Fatma Yılmaz Aydın","doi":"10.1007/s11255-025-04386-5","DOIUrl":"10.1007/s11255-025-04386-5","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic kidney disease (CKD) is a global public health issue, often associated with high mortality and morbidity, especially due to cardiovascular diseases. Epicardial adipose tissue (EAT), the visceral fat surrounding the heart, has been recognized as a significant factor in cardiovascular risk. This study aims to assess the relationship between EAT and body composition in patients with stage 4 and 5 CKD using bioelectrical impedance analysis (BIA).</p><p><strong>Methods: </strong>The study included 80 patients with stage 4 and 5 CKD who were not on dialysis. Body composition was measured using BIA, and EAT was assessed using transthoracic echocardiography(ECHO). Exclusion criteria included heart failure, morbid obesity, pregnancy, and pacemaker use, among others. Various demographic, clinical, and biochemical parameters were also recorded.</p><p><strong>Results: </strong>Patients with stage 5 CKD (6.7 ± 0.12) had significantly higher EAT compared to stage 4 CKD (5.9 ± 0.09) patients. EAT showed a positive correlation with age, BMI, blood pressure, C-reactive protein (CRP), and triglyceride levels, and a negative correlation with albumin and HDL levels. Multivariate analysis revealed that increased systolic blood pressure(SBP)(p:0.019),fat tissue mass (FTM)(p < 0.001), low HDL(p: 0.027), and low albumin(p < 0.001) were independent predictors of EAT.</p><p><strong>Conclusion: </strong>EAT is higher in advanced CKD patients and is associated with several cardiovascular risk factors. Measuring EAT in CKD patients using non-invasive methods like ECHO could be valuable in predicting cardiovascular risks. Addressing the factors that contribute to increased EAT may improve clinical outcomes for CKD patients.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1977-1982"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association of circulating immune cells with nephrotic syndrome: evidence from a two-sample Mendelian randomization study.","authors":"Sheng Li, Xing Zhou, Chengmeng Liu, Yijie Wang, Qianhui Zhou, Ting Sun","doi":"10.1007/s11255-024-04350-9","DOIUrl":"10.1007/s11255-024-04350-9","url":null,"abstract":"<p><strong>Objective: </strong>Nephrotic syndrome, a debilitating manifestation of kidney disease, often arises from diverse glomerular disorders and is accompanied by notable comorbidities. Despite indications of an immunological etiology, the precise role of immune cells in its pathogenesis remains unclear. This study aimed to elucidate the causal relationships between circulating immune cell phenotypes and nephrotic syndrome using a rigorous bidirectional Mendelian randomization approach.</p><p><strong>Methods: </strong>We conducted a bidirectional Mendelian randomization analysis leveraging public genome-wide association studies (GWAS) datasets to investigate the causal links between 731 immune cell features and nephrotic syndrome. Our primary analysis employed inverse variance weighting (IVW), complemented by MR-Egger regression, simple model, weighted median method, and weighted model techniques to ensure robustness. Sensitivity analyses were performed to address potential biases arising from heterogeneity, horizontal pleiotropy, and single-nucleotide polymorphism (SNP) instability in nephrotic syndrome.</p><p><strong>Results: </strong>Among traits examined, 13 immune cell phenotypes were identified to have significant causal impacts on nephrotic syndrome (adjusted P >  < 0.05). Among these phenotypes, CD25 on unswitched memory B cell, CD25 on memory B cell, CD25 on CD24 + CD27 + B cell, CD25 on IgD-CD38-B cell, CD33dim HLA DR-Absolute Count, and CD127 on granulocyte emerged as causal risk factors, while seven circulating immune cell phenotypes, predominantly monocyte subsets, exhibited protective effects. Furthermore, the reverse Mendelian randomization analysis demonstrated significant effects of nephrotic syndrome on 27 immune phenotypes (P < 0.05).</p><p><strong>Conclusion: </strong>The genetic predictions indicate that multiple circulating immune cell phenotypes, particularly CD25 on specific B-cell subsets, serve as independent risk factors for the onset and progression of nephrotic syndrome. Conversely, monocytes expressing specific phenotypes may exert protective effects against the development of nephrotic syndrome. These findings offer a novel therapeutic approach for the prevention and treatment of nephrotic syndrome.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1907-1917"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D: an important treatment for secondary hyperparathyroidism in chronic kidney disease?","authors":"Jie Yu, Yulu Li, Bin Zhu, Jianqin Shen, Liying Miao","doi":"10.1007/s11255-024-04334-9","DOIUrl":"10.1007/s11255-024-04334-9","url":null,"abstract":"<p><p>Secondary hyperparathyroidism (SHPT) is one of the most common complications of chronic kidney disease (CKD). Vitamin D levels begin to decrease in the early stages of CKD, and these vitamin D-related changes play a central role in the occurrence and development of SHPT. Vitamin D-based drugs, which inhibit parathyroid hormone secretion either directly or indirectly, are commonly used to treat SHPT. However, vitamin D-based drugs can also lead to a dysregulated balance between serum calcium and phosphorus, as well as other adverse reactions. Over the past several decades, researchers have conducted in-depth studies on the pathogenesis of SHPT, developed new vitamin D-based drugs, and explored combinatory methods to improve treatment efficacy for the disease. Here, we review vitamin D metabolism, the diagnosis of vitamin D deficiency in patients with CKD, the pathogenesis of SHPT, the pharmacological effects of vitamin D drugs, and the benefits and side effects of using vitamin D to treat SHPT.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1853-1863"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound radiomics model based on grayscale transrectal ultrasound-guided biopsy for diagnosing prostate cancer and predicting distant metastasis.","authors":"Jie Liu, Zhendong Xiang, Cheng Yi, Tianzi Yang, Dongting Liu","doi":"10.1007/s11255-025-04366-9","DOIUrl":"10.1007/s11255-025-04366-9","url":null,"abstract":"<p><strong>Objective: </strong>A prostate ultrasound (US) imaging omics model was established to assess its effectiveness in diagnosing prostate cancer (PCa), predicting Gleason score (GS), and determining the likelihood of distant metastasis.</p><p><strong>Methods: </strong>US images of patients with prostate pathology confirmed by biopsy or surgery at our hospital were retrospectively analyzed. Regions of interest (ROI) segmentation, feature extraction, feature screening, and the construction and training of the radiomics model were performed.</p><p><strong>Results: </strong>Area under the curve (AUC) for the magnetic resonance imaging Prostate Imaging Reporting and Data System (MRI PI-RADS) classification, radiomics alone, and radiomics combined with prostate-specific antigen (PSA) in diagnosing PCa were 70.74%, 71.13%, and 90.47%, respectively. AUCs for the MRI PI-RADS classification, radiomics alone, and radiomics combined with PSA in predicting the GS of PCa were 75.6%, 74.7%, and 88.9%, respectively. Furthermore, AUCs for MRI PI-RADS classification and radiomics alone in predicting distant metastasis of PCa were 66.7% and 90.8%, respectively.</p><p><strong>Conclusion: </strong>The combination of ultrasonic imaging omics and serum PSA significantly improves the efficiency of PCa diagnosis, GS prediction, and distant metastasis prediction. This method is an important tool for PCa screening and follow-up.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1797-1809"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of preoperative stenting in management of bilateral ureteral stones.","authors":"Muhammet Cicek, Mehmet Caglar Cakici, Adem Alcin, Selamettin Demir, Ramazan Gokhan Atis, Asif Yildirim","doi":"10.1007/s11255-025-04365-w","DOIUrl":"10.1007/s11255-025-04365-w","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the impact of preoperative stenting on surgical outcomes and complications in patients with bilateral ureteric stones, specifically assessing its role in reducing the need for subsequent interventions.</p><p><strong>Methods: </strong>A retrospective analysis was conducted at a tertiary center over eight years, involving 82 patients with bilateral ureteric stones. Patients were divided into two groups: Group 1 (no preoperative stenting) and Group 2 (preoperative stenting). Key data collected included demographics, preoperative stone sizes, preoperative serum creatinine levels, operative details, postoperative complications, and stone-free rates (SFR) at two weeks post-surgery. Statistical analyses were performed using SPSS 25.0.</p><p><strong>Results: </strong>Of the 54 patients analyzed (27 in each group), the mean age was 48.8 ± 12.7 for Group 1 and 52.3 ± 15.2 for Group 2. Group 2 exhibited significantly higher preoperative serum creatinine levels (p = 0.016). Secondary interventions were needed for 8 patients in Group 1 versus 3 in Group 2 (p = 0.042). The SFR was 67% in Group 1 and 78% in Group 2 (p = 0.361), indicating no statistically significant difference.</p><p><strong>Conclusion: </strong>Preoperative stenting may enhance the success of surgical interventions for bilateral ureteric stones, potentially reducing the need for further procedures. Further prospective studies are needed to validate these findings and optimize management strategies.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1811-1815"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond blood pressure: identifying factors associated with rapid kidney function decline in patients with CKD and coexisting COPD.","authors":"Areti Georgiou, Marieta Theodorakopoulou, Fotini Iatridi, Pantelis Sarafidis","doi":"10.1007/s11255-024-04325-w","DOIUrl":"10.1007/s11255-024-04325-w","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1985-1986"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}