International Urology and Nephrology最新文献

{"title":"Comment on \"Mortality trends of renal diseases due to hypertension in adults: an analysis of gender, race, place of death, and geographical disparities in the United States from 1999 to 2020\".","authors":"Abdul Waheed Rahimoon, Zakaullah Aziz","doi":"10.1007/s11255-025-04541-y","DOIUrl":"10.1007/s11255-025-04541-y","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3471-3472"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mineralocorticoid receptor antagonists promote renal immunosenescence.","authors":"Qiao-Rui Wang, Yi Yang","doi":"10.1007/s11255-025-04530-1","DOIUrl":"10.1007/s11255-025-04530-1","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is often associated with chronic inflammation, influenced by the activation of mineralocorticoid receptors (MR). This review focuses on changes in immune cells and explores the important role that MR antagonists (MRAs), especially the new nonsteroidal MRA, finerenone, play in alleviating renal and cardiac injury by affecting the transformation of stimulated immune cells. We found that MR can promote the transformation of macrophages to M1 pro-inflammatory phenotype through IL-14 receptor and mitogen-activated protein kinase (MAPK)-JNK. MR also activates helper T cells and reduces the generation of regulatory T cells by promoting the interaction between nuclear factor and activator protein-1, increasing the secretion of IL-2 and IL-18, increasing the expression of CD38 and CD69, especially the IL-17/IL-23 axis. The above immune system changes jointly mediate inflammation leading to kidney damage and fibrosis. In addition, we propose that the NLRP3 inflammasome is associated with macrophage imbalance. Preclinical studies indicate that finerenone effectively reduces inflammation and prevents structural kidney damage without significant systemic blood pressure changes. These data will provide some ideas for further research in the field of immune mechanisms in future, and drug research targeting specific targets and channels may also become a new type of diagnostic and treatment measure.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3299-3306"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weekend catch-up sleep is associated with a decreased risk of kidney disease in American adults: an analysis of NHANES 2017-2020.","authors":"Lianhua Geng, Yingchun Qin, Yuehua Gao, Wei Zhang","doi":"10.1007/s11255-025-04518-x","DOIUrl":"10.1007/s11255-025-04518-x","url":null,"abstract":"<p><strong>Background: </strong>In recent years, inadequate sleep duration has become a prominent concern all over the world, prompting investigations into its potential influences on various health conditions, including kidney disease. This study seeks to explore the association between weekend catch-up sleep (WCS) and kidney disease in American adults.</p><p><strong>Methods: </strong>A cross-sectional study was performed utilizing data from the National Health and Nutrition Examination Surveys (NHANES) spanning the years 2017-2020. The participants included who were 18 years old or older and clearly awareness of their sleep durations on weekdays and weekends. Sleep durations on weekdays and weekends were ascertained through questionnaires, and WCS was determined as the disparity between weekend and weekday sleep durations.</p><p><strong>Results: </strong>Participants with kidney disease exhibited notable variations in their weekday and weekend sleep durations in comparison to those without. The WCS of more than 2 h, irrespective of comorbidities such as hypertension and diabetes, was significantly linked to a lower prevalence of kidney disease, particularly in individuals who slept 6-8 h on weekdays. Furthermore, it was noted that there exists a non-linear correlation between WCS and the prevalence of kidney disease, with a distinct breakpoint identified at 3.5 h. The WCS of more than 2 h-possibly but not certainly-irrespective of comorbidities such as hypertension and diabetes, was significantly linked to a lower prevalence of kidney disease, particularly in individuals who slept 6-8 h on weekdays.</p><p><strong>Conclusion: </strong>This research indicates that among adults with insufficient weekday sleep in the United States, participation in WCS, particularly exceeding 2 h is significantly linked to a decreased prevalence of kidney disease. These results offer new perspectives on the connection between sleep patterns and kidney disease, which could inform preventive measures for this prevalent chronic condition.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3351-3364"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for coronary artery calcification in Chinese patients undergoing maintenance hemodialysis: a meta-analysis.","authors":"Mengjiao Li, Yuxia Li, Shuting Liu, Yan Yang, Ping Jiang","doi":"10.1007/s11255-025-04535-w","DOIUrl":"10.1007/s11255-025-04535-w","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Chronic kidney disease (CKD) progression to end-stage renal disease (ESRD) increases cardiovascular disease (CVD) risk, with coronary artery calcification (CAC) affecting 70% of Chinese maintenance hemodialysis (MHD) patients. Prolonged MHD treatment is linked to calcium-phosphorus imbalance and accelerated CAC progression. However, conflicting findings on CAC risk factors persist due to methodological heterogeneity in existing studies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To systematically analyze the risk factors for coronary artery calcification in patients undergoing maintenance hemodialysis in China.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted a computer-assisted search of ten databases, including PubMed, Web of Science, CBM, Wanfang, CNKI, and VIP, for observational studies (cohort, case-control, and cross-sectional studies) published from inception to October 21, 2024, on risk factors for coronary artery calcification (CAC) in Chinese patients with maintenance hemodialysis (MHD). The studies were independently screened by two investigators according to the PRISMA guidelines and diagnosed with coronary artery calcification through imaging techniques (CT). Odds ratios (ORs) and 95% confidence intervals (CIs) were used for the reported outcomes. The quality of the studies was assessed using the Newcastle-Ottawa Scale. A meta-analysis of the included data was performed using either a random effects model or a fixed effects model, we performed a meta-analysis using the Stata 17.0 software.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The review included 24 studies with a total sample size of 2,875 patients. A meta-analysis of these 24 studies (n = 2875) found that diabetes mellitus (OR = 2.32, 95% CI 1.37-3.27) and elevated iPTH (OR = 1.59, 95% CI 1.21-1.96) were the strongest predictors of an increased risk of coronary artery calcification (CAC) in Chinese maintenance hemodialysis (MHD) patients. Additionally, elevated high-sensitivity C-reactive protein (hs-CRP) levels, elevated serum calcium, advanced age, longer duration of dialysis treatment, elevated serum phosphorus, and elevated sclerostin (SOST) levels were significant predictors of an increased risk of concurrent CAC in Chinese MHD patients. However, the correlation between hypertension, serum magnesium, fibroblast growth factor-23 (FGF-23), alkaline phosphatase (ALP), and MHD with concomitant CAC was not significant, likely due to the wide variation in sample size and study type.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Diabetes mellitus and elevated iPTH are the most significant clinical risk factors for coronary artery calcification (CAC) in Chinese maintenance hemodialysis (MHD) patients, and healthcare professionals should prioritize this population. Additionally, monitoring calcium and phosphorus metabolism, along with inflammatory markers (e.g., hs-CRP, SOST), can further reduce the risk of cardiovascular disease. Early health education and targeted, individualized t","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3307-3318"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of structured pre-dialysis education on the clinical outcomes of kidney patients.","authors":"Zehra Aydin, Şeyda Özcan","doi":"10.1007/s11255-025-04554-7","DOIUrl":"10.1007/s11255-025-04554-7","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study is to evaluate the effect of pre-dialysis education on clinical, laboratory, quality of life, and self-care ability of patients on dialysis treatment.</p><p><strong>Methods: </strong>This observational study recruited 202 patients (108 patients who received systematic pre-dialysis education; education group- and 94 patients who started dialysis without education; noneducation group). We evaluated and compared quality of life, self-care ability, psychological/depressive status, and biochemical parameters between groups.</p><p><strong>Results: </strong>The education group had a significantly higher self-care score (98.3 ± 8.5) (82.4 ± 21.5, p < 0.001), lower depressive symptoms (2.8%, 0.9%, and 0.9%, respectively) compared with the non-education group (31.9%, 20.2%, and 2.8%, respectively, p < 0.001). Quality of life scale results were significantly higher in the education group (p < 0.001 for each). Phosphate, parathormone, BUN, and residual renal function level were significantly lower (p < 0.01), and haemoglobin was significantly higher (p < 0.01) compared to those in the non-education group.</p><p><strong>Conclusion: </strong>Our study shows that systematic education practices in the pre-dialysis period were associated with improved quality of life, increased self-care ability, increased psychosocial well-being, and positive effects on clinical outcomes in dialysis patients.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3461-3468"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival benefit of radical prostatectomy for non-metastatic prostate cancer: a propensity score-matched SEER database analysis.","authors":"Weijie Sun, Yiduo Cai, Xiangnan Feng, Yi Fan, Kun Zhang","doi":"10.1007/s11255-025-04466-6","DOIUrl":"10.1007/s11255-025-04466-6","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer exhibits high incidence among males, yet the clinical utility of surgical intervention for non-metastatic disease remains controversial.</p><p><strong>Methods: </strong>We extracted 290,749 cases from the SEER database (2010-2015) and categorized patients into a curative-directed surgery (CDS) group and a non-CDS group (surgery recommended but not performed). Propensity score matching (PSM) was applied to balance baseline characteristics. Survival analysis was conducted using Kaplan-Meier methods with stratified cumulative hazard curves, followed by multivariable Cox proportional hazards regression to estimate hazard ratios (HRs). Model selection was performed using the corrected Akaike Information Criterion (AICc).</p><p><strong>Results: </strong>After propensity score matching (PSM), each group consisted of 8,330 patients. The cumulative risk curves indicated no significant survival benefit in the CDS group compared to the non-CDS group (p = 0.34). Stratified analysis revealed age-dependent risk escalation, particularly pronounced in patients over 74 years old. Surgery was found to reduce the risk in stage T2 patients but had no such effect on stage T1 patients. Increased PSA levels and Gleason scores significantly worsened prognosis (p < 0.0001). Multivariate Cox regression analysis demonstrated that Gleason score is a critical factor influencing mortality risk, with high-risk Gleason scores (8-10) conferring a 6.31-fold (95% CI 6.23-8.58) increase in risk compared to low-risk scores (≤ 6), consistent with the trend observed in the cumulative risk curves.</p><p><strong>Conclusion: </strong>For non-metastatic prostate cancer, surgical intervention may not confer a survival benefit, underscoring the need for cautious clinical decision-making. These findings warrant validation through prospective studies to elucidate the underlying mechanisms and refine treatment guidelines.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3181-3190"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing causality between kidney stones and osteoporosis: strengths, gaps, and future needs.","authors":"Maryam Irshad, Shahzeen Irshad, Sehrish Irshad","doi":"10.1007/s11255-025-04587-y","DOIUrl":"10.1007/s11255-025-04587-y","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3473-3474"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of angiogenin in bladder cancer: where are we in 2025?","authors":"Thomas R Wong, Clara Sun, Braian Ledesma, Ilaha Isali","doi":"10.1007/s11255-025-04517-y","DOIUrl":"10.1007/s11255-025-04517-y","url":null,"abstract":"<p><strong>Purpose: </strong>The diagnosis of bladder cancer (BCa), a condition that represents approximately 4% of new cancer cases in the United States, could be greatly improved by the development of non-invasive biomarker-based testing. Current diagnostic methods include cystoscopy and cytology; however, these techniques are overly invasive and may cause patient discomfort. Angiogenin (ANG), a member of the RNase A superfamily, was implicated in tumor growth due to its role in angiogenesis. ANG pathophysiology and potential diagnostic and therapeutic role in BCa are discussed.</p><p><strong>Methods: </strong>A narrative review was conducted on the relationship between ANG and BCa. Articles were retrieved from PubMed and Google Scholar between the years of 2000 and 2024. The authors reviewed the included articles and summarized findings.</p><p><strong>Results: </strong>In BCa, ANG interacts with matrix metallopeptidase 2 (MMP2) through the ERK1/2 signaling pathway and contributes to extracellular matrix (ECM) degradation. This review, including 9 articles that directly assessed biomarker-based tests with ANG, suggests that ANG may be suitable for developing novel diagnostic urine biomarker tests. The overexpression of ANG in patients with BCa may also suggest the potential for developing therapeutics that target this protein. Some articles indicate that ribonuclease inhibitors could successfully target ANG by limiting nuclear translocation or limiting ANG activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways, thus limiting BCa progression.</p><p><strong>Conclusions: </strong>The results of this review warrant further investigation into both the diagnostic and therapeutic potential of ANG in BCa. Future case-control studies and clinical trials are needed.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3131-3142"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient satisfaction and decision regret in patients undergoing radical prostatectomy: a multicenter analysis.","authors":"Alessandro Guercio, Riccardo Lombardo, Beatrice Turchi, Matteo Romagnoli, Antonio Franco, Simone D'Annunzio, Ferdinando Fusco, Antonio Luigi Pastore, Yazan Al Salhi, Andrea Fuschi, Antonio Cicione, Giorgia Tema, Antonio Nacchia, Antonio Carbone, Giuseppe Simone, Cristian Fiori, Giovanni Busacca, Francesco Porpiglia, Marcello Scarcia, Andrea Tubaro, Cosimo De Nunzio","doi":"10.1007/s11255-025-04510-5","DOIUrl":"10.1007/s11255-025-04510-5","url":null,"abstract":"<p><strong>Introduction and aim: </strong>Prostate cancer (PCa) remains the most common non-cutaneous cancer among men in Europe, with treatment advances improving mortality outcomes. Radical prostatectomy (RP) is a key treatment option for localized PCa, anyway complications such as urinary incontinence and erectile dysfunction can influence patient satisfaction and decision regret. This multicenter study aims to identify factors that can assist urologists in improving preoperative counseling through levels of satisfaction or regret, with the goal of increasing patient awareness regarding the potential risks and complications associated with RP.</p><p><strong>Materials and methods: </strong>A prospective analysis was conducted on 590 patients undergoing RP across 4 Italian centers (from 2019 to 2022). Decision regret was assessed using the validated Decision Regret Scale (DRS). The mean score of the five items of the DRS was calculated and then converted to a 100-points scale, with a cutoff score of 25 distinguishing low from high regret. Logistic regression analysis evaluated predictors of treatment regret.</p><p><strong>Results: </strong>At a median follow-up of 23 months, 79% of patients reported low decision regret (DRS ≤ 25). Lower decision regret was associated with lower rates of urinary incontinence and erectile dysfunction. Multivariate analysis identified urinary continence (OR 3.8, p < 0.001), erectile function (OR 0.3, p < 0.001), and robotic surgery (OR 3.7, p = 0.009) as significant independent predictors of satisfaction. In addition, poorer quality of life correlated with increased regret.</p><p><strong>Conclusion: </strong>Our study emphasizes the importance of evaluating surgical outcomes to predict patient satisfaction, optimizing preoperative counseling, and reducing long-term regret. Urinary and sexual function, and surgical technique influence satisfaction and quality of life. Further research should explore patient-specific predictors and optimize timing for outcome evaluations.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3207-3213"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of artificial intelligence in predicting the renal function after nephrectomy in renal cell carcinoma: a systematic review and meta-analysis.","authors":"Mohamed Javid, Mahmoud Eldefrawy, Sai Raghavendra Sridhar, Mukesh Roy, Muni Rubens, Murugesan Manoharan","doi":"10.1007/s11255-025-04467-5","DOIUrl":"10.1007/s11255-025-04467-5","url":null,"abstract":"<p><strong>Purpose: </strong>To explore and assess the role of artificial intelligence (AI) in predicting the postoperative renal function in Renal Cell Carcinoma (RCC) patients undergoing nephrectomy.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases, including PubMed, Embase, Scopus, and Web of Science. PRISMA guidelines were followed throughout the systematic review and meta-analysis. The studies that used AI models to predict renal function after nephrectomy were included in our review. The details of different AI models, the input variables used to train and validate them, and the output generated from these models were recorded and analysed. The risk of bias was assessed using the Prediction Model Study Risk of Bias Assessment Tool (PROBAST).</p><p><strong>Results: </strong>After the screening, a total of nine studies were included for the final analysis. The most common AI algorithms that were used to predict were based on machine learning models, namely Random Forest (RF), support vector machine (SVM) and XGBoost. Different performance metrics of various AI models were analysed. The pooled AUROC (area under the receiver operating curve) of the AI models was 0.79 (0.75-0.84), I² = 15.26%.</p><p><strong>Conclusion: </strong>AI models exhibit significant potential for determining postoperative renal function in RCC patients. They integrate multimodal data to generate more accurate results. However, standardising the methodologies and reporting, utilising diverse datasets, and improving model interpretability can lead to widespread clinical adaptation.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3097-3106"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}