International Urology and Nephrology最新文献

筛选
英文 中文
Clinical characteristics and risk factors analysis of bilateral renal tuberculosis. 双侧肾结核的临床特点及危险因素分析。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-05-01 Epub Date: 2024-12-30 DOI: 10.1007/s11255-024-04332-x
Xiaoshan Li, Linping Qi, Xiumei Li, Lilong Ma, Shuyu Yang, Xueyi Huang, Weiping Li, Xiande Huang, Yindong Kang, Panfeng Shang
{"title":"Clinical characteristics and risk factors analysis of bilateral renal tuberculosis.","authors":"Xiaoshan Li, Linping Qi, Xiumei Li, Lilong Ma, Shuyu Yang, Xueyi Huang, Weiping Li, Xiande Huang, Yindong Kang, Panfeng Shang","doi":"10.1007/s11255-024-04332-x","DOIUrl":"10.1007/s11255-024-04332-x","url":null,"abstract":"<p><strong>Objective: </strong>To analyze and discuss the clinical characteristics and risk factors of bilateral renal tuberculosis.</p><p><strong>Methods: </strong>A retrospective study was performed on 446 patients who were diagnosed with renal TB. Among these patients, 69 patients with bilateral renal TB were selected as the observation group, and 377 patients with unilateral renal TB served as the control group. Logistic regression was used to analyze the age, sex, BMI, place of residence, comorbidities, time from onset to clinic visit, and treatment history to identify the risk factors for the occurrence of bilateral renal TB.</p><p><strong>Results: </strong>The univariate analysis showed that BMI (P = 0.003), place of residence (P = 0.048), combined with urinary calculi (P = 0.010), history of endoscopy (P < 0.001), and history of ureteral stenting (P < 0.001) were significantly associated with the incidence of bilateral renal TB. The multivariate analysis revealed BMI < 18.5 kg/m<sup>2</sup> (OR = 2.282, 95% CI 1.197-5.154, P = 0.015), rural residence (OR = 2.353, 95% CI 1.115-4.966, P = 0.025), combined with urinary calculi (OR = 2.152, 95% CI 1.177-3.933, P = 0.013), and history of endoscopy (OR = 3.973, 95% CI 1.369-11.535, P = 0.011) were identified as independent risk factors for the occurrence of bilateral renal TB.</p><p><strong>Conclusion: </strong>Such factors as rural residence, low BMI, urinary calculi, and previous history of endoscopic examination were identified as the main risk factors for the occurrence of bilateral renal TB.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1503-1512"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Goldstandard TUR-P: the bigger the volume, the higher the speed, but resected volumes of more than 60g are critical. 金标准turp:体积越大,速度越快,但切除体积超过60g是至关重要的。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-05-01 Epub Date: 2024-12-21 DOI: 10.1007/s11255-024-04329-6
Heinrich Schulte-Baukloh, Markus Weber, Dirk Höppner, Holger Heidenreich, Thorsten Schlomm, Sarah Weinberger, Thomas Enzmann, Bernhard Ralla
{"title":"Goldstandard TUR-P: the bigger the volume, the higher the speed, but resected volumes of more than 60g are critical.","authors":"Heinrich Schulte-Baukloh, Markus Weber, Dirk Höppner, Holger Heidenreich, Thorsten Schlomm, Sarah Weinberger, Thomas Enzmann, Bernhard Ralla","doi":"10.1007/s11255-024-04329-6","DOIUrl":"10.1007/s11255-024-04329-6","url":null,"abstract":"<p><strong>Background: </strong>According to the European Association of Urology guidelines, the limit for monopolar, transurethral resection (M-TURP) in BPH- therapy is a volume of 80 g. However, whether larger prostates can also be resected transurethrally might also depend on the experience of the surgeon and especially the resected volume and speed of the resection. Little is known about the latter, and this paper aims to these factors.</p><p><strong>Methods: </strong>This study included 540 patients who received a single-stage M-TURP. Based on the postoperative resection weight, these were divided into four groups: group 1 with 10 to 59.9 g, group 2 with 60 to 79.9 g, group 3 with 80 to 99.9 g, and group 4 with ≥ 100 g. We examined patient age, the ASA-score, the IPSS, quality of life, resection weight, time and speed, pre- and postoperative hemoglobin and serum sodium values, complications, and surgeon experience.</p><p><strong>Results: </strong>The mean resection weight was 41.6 g, and the mean values for resection time and speed were 61.3 min and 0.7 g/min, respectively. The resection speed increased significantly with resection weight (from 0.7 to 1.3 g/min) as well as with the surgeon's level of experience (from 0.4 to 0.9 g/min). The number of serious complications (Clavien-Dindo ≥ IIIb) increased significantly from a resection volume of 59.5 g (cut-off value). The resection speed of M-TURP increased significantly with the resection weight and the surgeon's level of experience. Regardless of speed, resection weight of more than 60 g might increase the risk of severe complications.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1415-1423"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening for nasal carriage of Staphylococcus (S.) aureus reduces the risk of S. aureus peritonitis in patients on peritoneal dialysis (PD). 筛查金黄色葡萄球菌(S.)鼻腔携带可降低腹膜透析(PD)患者发生金黄色葡萄球菌腹膜炎的风险。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-05-01 Epub Date: 2024-12-30 DOI: 10.1007/s11255-024-04309-w
Gaetano Alfano, Michele Pittiglio, Camilla Ferri, Roberta Romaniello, Giuseppe Oliviero, Ylenia Cancelli, Laura Melara, Laura Tonelli, Martina Montani, Davide Raimondo, Niccolò Morisi, Giulia Ligabue, Silvia Giovanella, Francesco Fontana, Riccardo Magistroni, Gabriele Donati
{"title":"Screening for nasal carriage of Staphylococcus (S.) aureus reduces the risk of S. aureus peritonitis in patients on peritoneal dialysis (PD).","authors":"Gaetano Alfano, Michele Pittiglio, Camilla Ferri, Roberta Romaniello, Giuseppe Oliviero, Ylenia Cancelli, Laura Melara, Laura Tonelli, Martina Montani, Davide Raimondo, Niccolò Morisi, Giulia Ligabue, Silvia Giovanella, Francesco Fontana, Riccardo Magistroni, Gabriele Donati","doi":"10.1007/s11255-024-04309-w","DOIUrl":"10.1007/s11255-024-04309-w","url":null,"abstract":"<p><strong>Introduction: </strong>Screening for nasal carriage of Staphylococcus (S.) aureus is associated with a reduction of peritoneal dialysis (PD)-related infections, but conflicting results have questioned the benefit of this practice. This study evaluated the clinical effectiveness of the screening program for nasal carriage of S. aureus in reducing the peritonitis rate in the PD population.</p><p><strong>Methods: </strong>A single-center retrospective study was conducted on all patients on PD diagnosed with peritonitis from 1999 to 2023. From 2011, screening for S. aureus with nasal swabs was implemented in our program. It was performed before the start of PD and in any case of peritonitis. Consequently, the study period was divided into pre-screening (1999-2010) and screening (2011-2023) phases.</p><p><strong>Results: </strong>The study included 195 patients who experienced 345 peritonitis episodes. Median age was 67 years. The overall peritonitis rate was 0.21 episodes/patient-year. Post-screening, the S. aureus peritonitis rate decreased significantly from 0.036 to 0.009 episodes/patient-year (P < 0.001). The screening did not reduce the total episodes of peritonitis (0.23 vs. 0.19 episodes/patient-year). Indeed, the cumulative peritonitis rate difference between the two phases was not significant (P = 0.31). The screening of previously decolonized patients with S. aureus peritonitis showed that 50% of them were colonized by S. aureus and that recolonization frequently occured in this population. Multivariate regression analysis showed that S. aureus screening was the only protective measure to reduce the risk of S. aureus peritonitis (OR, 0.36; CI<sub>95%</sub> 0.14-0.91; P = 0.03).</p><p><strong>Conclusions: </strong>In our center, screening for nasal carriage of S. aureus significantly reduced the incidence of S. aureus peritonitis but did not impact the overall peritonitis rate. Recolonization is a real event that warrants a better preventive strategy.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1639-1648"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress of traditional Chinese medicines in regulating acute kidney injury-related ferroptosis: a literature review. 中药调节急性肾损伤相关铁中毒的研究进展:文献综述。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-05-01 Epub Date: 2024-12-16 DOI: 10.1007/s11255-024-04302-3
Tao Peng, Mingquan Li
{"title":"Research progress of traditional Chinese medicines in regulating acute kidney injury-related ferroptosis: a literature review.","authors":"Tao Peng, Mingquan Li","doi":"10.1007/s11255-024-04302-3","DOIUrl":"10.1007/s11255-024-04302-3","url":null,"abstract":"<p><p>Ferroptosis plays a significant role in the pathological mechanism of acute kidney injury (AKI) for many etiologies. The characteristics of ferroptosis involve many aspects, including iron metabolism, lipid metabolism, and glutathione metabolism. In terms of iron metabolism, ferroptosis involves the accumulation of labile iron; in terms of lipid metabolism, ferroptosis involves the peroxidation of lipids, especially certain phospholipids; in terms of glutathione metabolism, ferroptosis involves the reduction of reduced glutathione (GSH) levels, leading to a decrease in the activity of glutathione peroxidase 4 (GPX4). A lot of traditional Chinese medicines (TCMs) have been reported to have a protective effect against AKI, and many of these TCMs have shown a close association with regulating ferroptosis in ameliorating AKI. While the mechanisms through which these TCMs regulate ferroptosis associated with AKI are intricate, many of their targets are linked to the inhibition of lipid peroxidation or the regulation of iron metabolism. This article discusses some aspects of AKI and ferroptosis, and reviews some research progress on the regulation of AKI-related ferroptosis by TCMs.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1601-1608"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nephrotoxicity of CAR-T therapy in patients with relapsed and refractory multiple myeloma. CAR-T治疗复发和难治性多发性骨髓瘤患者的肾毒性。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-05-01 DOI: 10.1007/s11255-025-04503-4
Zihan Chen, Yegan Chen, Jiaying Liu, Yingjun Sun, Xiaoxue Zhang, Lingyan Shao, Dandan Wang, Xue Wang, Wei Chen, Wei Sang, Kunming Qi, Zhenyu Li, Cai Sun, Ming Shi, Jianlin Qiao, Qingyun Wu, Lingyu Zeng, Junnian Zheng, Kailin Xu, Li Li, Hai Cheng, Jiang Cao
{"title":"Nephrotoxicity of CAR-T therapy in patients with relapsed and refractory multiple myeloma.","authors":"Zihan Chen, Yegan Chen, Jiaying Liu, Yingjun Sun, Xiaoxue Zhang, Lingyan Shao, Dandan Wang, Xue Wang, Wei Chen, Wei Sang, Kunming Qi, Zhenyu Li, Cai Sun, Ming Shi, Jianlin Qiao, Qingyun Wu, Lingyu Zeng, Junnian Zheng, Kailin Xu, Li Li, Hai Cheng, Jiang Cao","doi":"10.1007/s11255-025-04503-4","DOIUrl":"https://doi.org/10.1007/s11255-025-04503-4","url":null,"abstract":"<p><strong>Objective: </strong>Chimeric antigen receptor T (CAR-T) cell therapy has achieved impressive efficacy in treating relapsed and refractory multiple myeloma (R/R MM). Nephrotoxicity after CAR-T cell therapy has rarely been reported.</p><p><strong>Methods: </strong>We investigated the occurrence and clinical outcomes of acute kidney injury (AKI) in 111 patients with R/R MM after CAR-T cell therapy.</p><p><strong>Results: </strong>Thirteen patients (12.1%) developed AKI within 1 month of CAR-T cell therapy, of which 11 had grade 1 AKI, 1 had grade 2, and 1 had grade 3. Eleven (84.6%) cases resolved within 1 month after CAR-T cell therapy. The baseline tumor burden was an independent risk factor for the development of AKI. The finding of a high baseline tumor burden or hyponatremia after CAR-T cell therapy and close monitoring of lactate dehydrogenase, uric acid, interleukin (IL)-5 and IL-10 levels were helpful in predicting the development of AKI. The incidence of cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome were similar between the AKI and non-AKI groups. There was also no significant difference in clinical efficacy between the two groups.</p><p><strong>Conclusion: </strong>AKI is a mild severity and reversible complication. It has no impact on clinical outcomes in R/R MM patients receiving CAR-T cell therapy.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of microsurgical varicocelectomy performed for infertility on premature ejaculation. 显微外科精索静脉曲张切除术治疗不孕症对早泄的影响。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-05-01 Epub Date: 2024-12-21 DOI: 10.1007/s11255-024-04330-z
Yalcin Kizilkan, Mesut Berkan Duran, Mehmet Vehbi Kayra, Bahadir Sahin, Serdar Toksoz, Mehmet Hamza Gultekin, Omer Yildirim, Murat Gul, Nebil Akdogan, Kagan Turker Akbaba, Iyimser Ure, Eray Hasirci, Oguzhan Kahraman, Erman Ceyhan, Abdulmecit Yavuz, Ugur Akgun, Onder Cinar, Umit Gul, Hasan Deliktas, Hamdi Ozkara, Tahsin Turunc
{"title":"The effects of microsurgical varicocelectomy performed for infertility on premature ejaculation.","authors":"Yalcin Kizilkan, Mesut Berkan Duran, Mehmet Vehbi Kayra, Bahadir Sahin, Serdar Toksoz, Mehmet Hamza Gultekin, Omer Yildirim, Murat Gul, Nebil Akdogan, Kagan Turker Akbaba, Iyimser Ure, Eray Hasirci, Oguzhan Kahraman, Erman Ceyhan, Abdulmecit Yavuz, Ugur Akgun, Onder Cinar, Umit Gul, Hasan Deliktas, Hamdi Ozkara, Tahsin Turunc","doi":"10.1007/s11255-024-04330-z","DOIUrl":"10.1007/s11255-024-04330-z","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of varicocelectomy on premature ejaculation (PE) in patients with varicocele and infertility.</p><p><strong>Methods: </strong>A total of 82 sexually active patients aged 18 years or over who had undergone microscopic subinguinal varicocelectomy with a clinical diagnosis of varicocele in 14 urology clinics between October 2021 and March 2023 with primary infertility were evaluated prospectively Patients were evaluated using the Turkish validated form of the 'Premature Ejaculation Diagnostic Tool' (PEDT) scale. A PEDT score of 11 or above was taken to indicate the presence of PE. Turkish validated forms of PEDT and International Index of Erectile Function-5 (IIEF-5) were completed in all patients pre-operatively and at 3 and 6 months post-operatively. Intravaginal ejaculatory latency time (IELT) and serum testosterone measurements were also recorded.</p><p><strong>Results: </strong>Left varicocelectomy was performed in 70.7% and bilateral varicocelectomy in 29.3% of the participants. A significant difference was found between pre- and post-operative PEDT scores (× 2 (2) = 130.1, p < 0.001). A significant difference was observed between pre- and post-operative IELT time (× 2 (2) = 143.2, p < 0.001). IIEF-5 scores differed before and after surgery (× 2 (2) = 59.5, p < 0.001). A difference was found between the testosterone levels measured before and after surgery (× 2 (2) = 40.9, p < 0.001). No statistically significant difference was observed between the third- and sixth-month testosterone values (p = 0.183). Testosterone levels (p = 0.001) and IELT scores (p < 0.001) were significantly higher, while PEDT scores (p < 0.001) were significantly lower in the bilateral varicocelectomy group at the sixth post-operative month.</p><p><strong>Conclusion: </strong>In light of our findings, it is recommended that infertile patients with varicocele be informed of the positive effects of varicocelectomy on PE.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1425-1431"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical malpractice related to urology: an analysis of court decisions in Turkey. 与泌尿外科有关的医疗事故:土耳其法院判决分析。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-05-01 Epub Date: 2024-12-28 DOI: 10.1007/s11255-024-04354-5
Umit Uysal, Murat Ucar
{"title":"Medical malpractice related to urology: an analysis of court decisions in Turkey.","authors":"Umit Uysal, Murat Ucar","doi":"10.1007/s11255-024-04354-5","DOIUrl":"10.1007/s11255-024-04354-5","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study is to examine the lawsuits filed against urologists in Turkey, to reveal the results of these lawsuits and the sub-branch of urology they are related to, to discuss the possible reasons for the lawsuits and what can be done to prevent them.</p><p><strong>Materials and methods: </strong>The case outcomes obtained using the keyword \"Urology\" from the publicly accessible official website of the Presidency of the Supreme Court of the Republic of Turkey between 2018 and 2024 were analyzed by two expert urologists.</p><p><strong>Results: </strong>Of the 215 cases reviewed, the outcomes of 25 cases that met our inclusion criteria were analyzed. Sixteen of these cases were filed against private hospitals. Fourteen of the Supreme Court rulings involved civil (compensation) lawsuits, while 11 were criminal cases. Thirteen cases were related to endourology, and 9 patients had urinary system stone disease. Seventeen of the lawsuits involved allegations of postoperative medical errors. Five cases were attributed to procedural skill errors, and four were due to a lack of informed consent. Complications led to the death of seven patients. The decisions of the first-instance courts resulted in 12 acquittals, 7 compensation rulings, and 6 criminal convictions. At the Supreme Court level, 12 cases were ruled against the physicians.</p><p><strong>Conclusions: </strong>Nearly half of the cases resulted in rulings against urologists, with the majority being related to endourology. Our study emphasizes the importance of adhering to international medical guidelines, providing informed consent to patients, and carefully conducting postoperative follow-ups.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1481-1491"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PLAP expression is linked to invasive tumor growth in urothelial carcinoma of the bladder. PLAP 的表达与膀胱尿路上皮癌的浸润性肿瘤生长有关。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-05-01 Epub Date: 2024-12-16 DOI: 10.1007/s11255-024-04319-8
Henning Plage, Kira Furlano, Sebastian Hofbauer, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Maximilian Lennartz, Andreas Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Tobias Klatte, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Joachim Weischenfeldt, Thorsten Schlomm, David Horst, Henrik Zecha, Martina Kluth, Sarah Weinberger
{"title":"PLAP expression is linked to invasive tumor growth in urothelial carcinoma of the bladder.","authors":"Henning Plage, Kira Furlano, Sebastian Hofbauer, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Maximilian Lennartz, Andreas Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Tobias Klatte, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Joachim Weischenfeldt, Thorsten Schlomm, David Horst, Henrik Zecha, Martina Kluth, Sarah Weinberger","doi":"10.1007/s11255-024-04319-8","DOIUrl":"10.1007/s11255-024-04319-8","url":null,"abstract":"<p><strong>Purpose: </strong>Placental alkaline phosphatase (PLAP) is a protein with a poorly understood function that is normally only expressed in the placenta. In cancer, PLAP expression is a hallmark of germ cell neoplasms, but it can also occur in urothelial carcinoma. To evaluate the potential clinical significance of PLAP expression in bladder cancer, METHODS: PLAP protein was analyzed by immunohistochemistry in more than 2500 urothelial bladder carcinomas in a tissue microarray format.</p><p><strong>Results: </strong>PLAP staining was absent in normal urothelial cells but was observed in 15.9% of urothelial carcinomas, including 282 (11.5%) with weak, 57 (2.3%) with moderate, and 51 (2.1%) with strong staining. PLAP positivity occurred in 4.1% of 413 pTa G2 low-grade, 10.2% of 176 pTa G2 high-grade, and 7.2% of 97 pTa G3 tumors (p = 0.0636). As compared to pTa tumors, the PLAP positivity rate was markedly higher in 1341 pT2-4 carcinomas (19.8%, p < 0.0001). Within pT2-4 carcinomas, PLAP staining was unrelated to pT, pN, grade, L-status, V-status, overall survival, recurrence-free survival, and cancer-specific survival (p > 0.25). However, PLAP positivity was linked to p16 positivity (p = 0.0185), GATA3 positivity (p < 0.0001), and p63 expression loss (p = 0.0456).</p><p><strong>Conclusion: </strong>In summary, these data show that PLAP is expressed in a significant fraction of pT2-4 urothelial carcinomas, unrelated to cancer aggressiveness but associated with specific molecular features. Once anti-PLAP cancer drugs become effective, urothelial carcinoma is a candidate tumor entity for clinical evaluation.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1381-1388"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of extended immunotherapy in advanced clear cell renal cell carcinoma treated with first-line combination of immune-checkpoint inhibitor and tyrosine kinase inhibitor. 免疫检查点抑制剂和酪氨酸激酶抑制剂一线联合治疗晚期透明细胞肾细胞癌扩展免疫治疗的应用。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-05-01 Epub Date: 2024-12-24 DOI: 10.1007/s11255-024-04344-7
Qian Wang, Xingming Zhang, Qiyu Zhu, Hong Zeng, Jindong Dai, Junru Chen, Jinge Zhao, Guangxi Sun, Zhenhua Liu, Hao Zeng, Pengfei Shen
{"title":"Application of extended immunotherapy in advanced clear cell renal cell carcinoma treated with first-line combination of immune-checkpoint inhibitor and tyrosine kinase inhibitor.","authors":"Qian Wang, Xingming Zhang, Qiyu Zhu, Hong Zeng, Jindong Dai, Junru Chen, Jinge Zhao, Guangxi Sun, Zhenhua Liu, Hao Zeng, Pengfei Shen","doi":"10.1007/s11255-024-04344-7","DOIUrl":"10.1007/s11255-024-04344-7","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and safety of extended immunotherapy in first-line immune checkpoint inhibitors (ICIs)-tyrosine kinase inhibitors (TKIs) combination treatment for advanced renal cell carcinoma (RCC).</p><p><strong>Patients and methods: </strong>We retrospectively analyzed data from patients with advanced RCC who received first-line ICIs-TKIs combination treatment at West China Hospital of Sichuan University between October 2018 and July 2024. Patients who are assessed as having a disease control status after 2 years of continuous treatment will continue to receive immune checkpoint inhibitors until the inhibitors are discontinued due to disease progression or death.</p><p><strong>Result: </strong>A total of 86 patients were screened and 14 patients diagnosed with clear cell RCC (ccRCC) were enrolled. After 65 months of follow-up, three-year progression-free survival (PFS) rate was 71.4% and 4 year PFS rate was 59.5%. The 5 year overall survival (OS) rate was 58.3%. During extended treatment, one patient (7.1%) experienced a transition from stable disease (SD) to partial response (PR) and two patients (14.3%) experienced a transition from PR to complete response (CR). The best tumor shrinkage rates presenting after 24 months had longer PFS and OS compared to those presenting within 24 months (median PFS: not reached vs. 36 months; Hazard Ratio (HR) = 0.10, 95% CI 0.01-0.80, P = 0.03). For safety, extended immunotherapy did not increase treatment-related toxicities compared to safety profile before 24 months.</p><p><strong>Conclusion: </strong>Our analysis of real-world data indicates that patients with extended immunotherapy after 24 months had potential survival benefits and manageable toxicity. Large-scale, prospective studies are still needed to further verify the conclusion.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1433-1440"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "association of body roundness index with chronic kidney disease: a population-based cross-sectional study from NHANES 1999-2018". 对“身体圆度指数与慢性肾脏疾病的关联:NHANES 1999-2018基于人群的横断面研究”的评论。
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-05-01 Epub Date: 2024-11-29 DOI: 10.1007/s11255-024-04315-y
Feng Jin
{"title":"Comment on \"association of body roundness index with chronic kidney disease: a population-based cross-sectional study from NHANES 1999-2018\".","authors":"Feng Jin","doi":"10.1007/s11255-024-04315-y","DOIUrl":"10.1007/s11255-024-04315-y","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"1655-1656"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信