International Urology and Nephrology最新文献

{"title":"The association between the presence of kidney stones and the risk of developing osteoporosis: a NHANES-based cross-sectional study and Mendelian randomization analysis.","authors":"Juefei Dong, Weibin Hou, Guangming Yin, Jinrong Wang, Long Wang, Jianye Liu, Xianzhen Jiang, Jing Tan","doi":"10.1007/s11255-024-04324-x","DOIUrl":"https://doi.org/10.1007/s11255-024-04324-x","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether the presence of kidney stones increases the risk of developing osteoporosis.</p><p><strong>Methods: </strong>First, we performed an observational study on the basis of data from the National Health and Nutrition Examination Survey (NHANES; 2007-2020). Kidney stone patients were identified on the basis of their affirmative response to the question \"Have you ever experienced kidney stones?\" (KIQ026). Participants whose T score at the femoral neck was < -2.5 were defined as osteoporosis patients. Multivariable-adjusted logistic regression was used to assess the correlation between the presence of kidney stones and the risk of developing osteoporosis. Second, Mendelian randomization (MR) was applied to further investigate the causal relationship between the presence of kidney stones and the risk of developing osteoporosis. Genetic instruments were obtained from large genome-wide association studies (GWASs) from the UK Biobank and FinnGen Biobank. Inverse-variance weighting (IVW) was the primary analytical method used.</p><p><strong>Results: </strong>After adjustment for demographic and other covariates, a significant association between the presence of kidney stones and the risk of developing osteoporosis was detected (OR 1.778, CI: 1.345-2.351, P < 0.001). The MR results further revealed that genetically speaking, the presence of kidney stones was causally associated with a greater risk of developing osteoporosis (IVW: OR 1.088, CI: 1.015-1.167, P < 0.05).</p><p><strong>Conclusion: </strong>The presence of kidney stones is associated with an increased risk of developing osteoporosis. Further prospective cohort studies are needed to validate our results.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity measurement methods estimated mortality risk in patients undergoing hemodialysis: a systematic review and meta-analysis.","authors":"Henni Kusuma, Huan-Fang Lee, Miaofen Yen, Susan Jane Fetzer, Le Trinh Lam","doi":"10.1007/s11255-024-04312-1","DOIUrl":"https://doi.org/10.1007/s11255-024-04312-1","url":null,"abstract":"<p><strong>Purpose: </strong>The impact of obesity on mortality risk in patients undergoing hemodialysis (HD) remains uncertain due to conflicting findings across obesity measurement methods. This study aimed to assess the obesity measurements influence mortality risk in HD populations.</p><p><strong>Methods: </strong>Systematic review and meta-analysis were conducted following PRISMA guidelines, registered on PROSPERO (CRD42023429943). Relevant observational studies analyzing mortality risk using obesity measurements in adult HD patients up to March 27, 2023 were included from multiple databases, including EMBASE, MEDLINE (OVID), and CINAHL (EBSCO). Pooled analyses with a random-effects model were performed using RevMan 5.4.</p><p><strong>Results: </strong>Twenty-three studies involving 381,580 subjects were reviewed. A meta-analysis of 15 studies in event-based analysis showed contrasting results between anthropometry and body composition analysis in predicting all-cause mortality. Obese patients indicated by body mass index (BMI) had a lower mortality risk than non-obese patients (RR = 0.73, 95% CI: 0.70-0.76, p < 0.001). In contrast, abdominal obesity measured by waist circumference (WC) or waist-to-hip ratio (WHR) increased mortality risk (RR = 1.35, 95% CI: 1.01-1.80, p = 0.04). Studies using bioelectrical impedance analysis (BIA) demonstrated an increased mortality risk for obese patients (RR = 1.22, 95% CI: 1.05-1.41, p = 0.009).</p><p><strong>Conclusions: </strong>Obese patients undergoing HD exhibit different mortality risks depending on the methods of obesity measurement. The observed 'obesity paradox' in patients on HD, where lower mortality is seen with obesity measured by BMI, may reflect BMI's limitations in differentiating fat mass. More studies with other anthropometry and body composition analysis are needed to clarify this phenomenon.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing post-treatment urinary and colorectal procedures in prostate cancer patients using population-based linked data.","authors":"Tenaw Tiruye, Alex Jay, Braden Higgs, Michael O'Callaghan, Liesel M FitzGerald, Kim Moretti, David Roder, Kerri Beckmann","doi":"10.1007/s11255-024-04304-1","DOIUrl":"https://doi.org/10.1007/s11255-024-04304-1","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate urinary and colorectal procedures among men who underwent radical prostatectomy (RP) and external beam radiotherapy (EBRT).</p><p><strong>Methods: </strong>We studied 16,271 (RP = 8516 and EBRT = 7755) South Australian men diagnosed with prostate cancer between 2001 and 2021. Colorectal and urinary procedures were extracted from hospital admission procedure codes and Medical Benefits Schedule item codes. Rates were estimated at 30-days, 90-days, 6-months, 1-year, 2-years and 5-years post-treatment. We estimated the average treatment effect of RP (compared with EBRT) by applying propensity-matched analyses, accounting for sociodemographic and clinical characteristics. Subgroup analyses were undertaken for different treatment periods (2001-2010 vs. 2011-2021).</p><p><strong>Results: </strong>At 1-year post-treatment, the crude rates of colorectal procedures were 43 and 70/1000 person-years among RP and EBRT patients, respectively, while crude rates for urinary procedures were 258 and 74/1000 person-years, respectively. Propensity matched analyses indicated that patients undergoing RP underwent more post-treatment urinary procedures, being 21.2% higher at 6-months and 16.3% higher at 5-years than men who received EBRT. Colorectal procedures were slightly more frequent among RP than EBRT patients during the first 90-days but less frequent from 1-year onwards (5.9% lower at 5-years among RP group). Between 2011 and 2021, there were considerably fewer urinary procedures for men who underwent RP than those treated between 2001 and 2010.</p><p><strong>Conclusion: </strong>There is a statistically significant difference in the frequency of post-treatment procedures between patients who underwent RP and those who had EBRT, which likely indicates a difference in adverse treatment effects. These findings may lead to more informed treatment decision-making.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of suction technique and non-suction technique in retrograde intrarenal stone surgery: a systematic review and meta-analysis.","authors":"Pengan Chen, Gaoshen Mi, Jixiang Chen, Yu Liu, Zhongyu Jian, Xi Jin, Kunjie Wang","doi":"10.1007/s11255-024-04280-6","DOIUrl":"https://doi.org/10.1007/s11255-024-04280-6","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of retrograde intrarenal stone surgery (RIRS) using the vacuum suction technique for the treatment of upper urinary calculi.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases, including PubMed, Embase, Sino Med, CNKI, WANFANG DATA, and Cochrane. We included studies comparing vacuum suction RIRS with non-vacuum RIRS. Following the PRISMA guidelines, we performed a meta-analysis of the selected studies. Inclusion criteria were randomized controlled trials (RCTs), case-control studies, and retrospective studies evaluating the efficacy of these techniques. Key outcomes analyzed included operative time, hospitalization duration, stone-free rates, and complication rates. Statistical analyses were conducted using mean differences (MD) for continuous variables and odds ratios (OR) for dichotomous outcomes, with corresponding 95% confidence intervals (CI).</p><p><strong>Results: </strong>Sixteen studies (6 RCTs, 1 case-control study, and 9 retrospective studies) involving a total of 2029 patients were included. Meta-analysis revealed that the vacuum suction technique significantly reduced operative time (MD = - 14.45 min, 95% CI [- 18.45; - 10.44], P < 0.00001) and hospital stay (MD = - 0.54 days, 95% CI [- 0.80; - 0.28], P < 0.00001). In addition, patients in the vacuum suction group had a higher stone-free rate (OR = 3.57, 95% CI [2.57; 4.95], P < 0.00001) and lower complication rates, particularly in reducing postoperative fever.</p><p><strong>Conclusion: </strong>The application of the vacuum suction technique in RIRS significantly improves clinical outcomes by reducing operative time and hospitalization duration, enhancing stone-free rates, and lowering postoperative complication rates. This technique demonstrates a clear clinical advantage over non-vacuum RIRS and should be considered a preferred option for the management of upper urinary tract stones.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota may mediate the causality of statins on diabetic nephropathy: a mediation Mendelian randomization study.","authors":"Xiaoli Wen, Gaosi Xu","doi":"10.1007/s11255-024-04321-0","DOIUrl":"https://doi.org/10.1007/s11255-024-04321-0","url":null,"abstract":"<p><strong>Background: </strong>Increasing evidence indicates that statins may increase the risk of developing diabetic nephropathy (DN). As the gut-kidney axis concept gains traction, it remains unclear whether statins contribute to the onset and progression of DN by modulating gut microbiota.</p><p><strong>Objective: </strong>To investigate the association between statins and DN and the proportion of this association mediated through gut microbiota.</p><p><strong>Method: </strong>This study utilized a two-sample Mendelian randomization (MR) approach and a cross-sectional observational design to investigate the causal relationships among statins, 473 gut microbiota, and DN. Furthermore, mediation MR analysis was employed to explore the potential mediating effects of gut microbiota in the statins-DN relationship.</p><p><strong>Results: </strong>HMGCR inhibitors were causally linked to the increased incidence of DN (odds ratio [OR]: 0.732, 95% confidence interval [CI] 0.647, 0.828, P_FDR = 0.000004). Supporting results from a cross-sectional study based on the Medical Information Marketplace in Intensive Care (MIMIC-IV) database also indicated this association (OR: 0.74, 95% CI: 0.61, 0.91, P = 0.004). Among the 473 identified gut microbiota species, 13 (P_FDR < 0.05) were causally associated with DN. The mediation MR analysis revealed that 10 gut microbiota mediated the relationship between statins and DN, acting as either protective or risk factors (P < 0.05). In addition, HMGCR and related proteins may be involved in lipid metabolism, insulin resistance, and AMPK signaling pathway.</p><p><strong>Conclusion: </strong>Statins may become a risk factor for DN by increasing or decreasing the abundance of specific gut microbiota. These specific gut bacteria have the potential to become a new indicator for guiding the clinical use of statins in diabetic patients.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vancomycin-associated acute kidney injury in underweight patients: a propensity score matching analysis.","authors":"Tatsuya Okuwaki, Masahiro Kobayashi, Rino Kikuchi, Yoshinori Tomoda, Moeka Ogawa, Kumi Kasugai, Yoshinori Seto, Atsushi Tomizawa, Katsuya Otori","doi":"10.1007/s11255-024-04306-z","DOIUrl":"https://doi.org/10.1007/s11255-024-04306-z","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of being underweight on the incidence of vancomycin-associated acute kidney injury (AKI) using propensity score matching analysis.</p><p><strong>Methods: </strong>This study is a retrospective analysis of patients who received vancomycin and had their serum concentration measured at Kitasato University Hospital between January 1, 2016 and December 31, 2020. Patients were divided into underweight and non-underweight groups based on body mass index (BMI), and propensity score matching analysis was used to evaluate whether underweight affected the incidence of acute kidney injury.</p><p><strong>Results: </strong>480 patients met the selection criteria, and 111 patients from each group (BMI < 18.5 and BMI ≥ 18.5) were successfully matched using propensity score matching. After matching, there were no differences in non-physical characteristics between the two groups. The incidence of AKI was 23.4% (26 of 111) in the BMI < 18.5 group and 37.8% (42 of 111) in the BMI ≥ 18.5 group, with the BMI < 18.5 group having a significantly lower incidence. The odds ratio was 0.503 [95% CI 0.281-0.900].</p><p><strong>Conclusion: </strong>This study showed that underweight patients (BMI < 18.5) had a significantly lower incidence of vancomycin-associated AKI compared to those with BMI ≥ 18.5. As there have been no previous reports on the association between underweight and vancomycin-associated AKI, this study provides novel insights.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The safety and efficacy of regional citrate anticoagulation for multiple consecutive therapeutic plasma exchanges with fresh frozen plasma as a replacement solution.","authors":"Tong Liu, Jing Jiao, Siwei Tang, Siyan Tang, Lecheng She, Xiujuan Tian, Shidong Feng, Xiaolan Chen, Rui Lu, Yan Yu, Xiaoling Qi, Yajuan Li, Shiren Sun, Ming Bai","doi":"10.1007/s11255-024-04305-0","DOIUrl":"https://doi.org/10.1007/s11255-024-04305-0","url":null,"abstract":"<p><strong>Background: </strong>Therapeutic plasma exchange (TPE) is an important blood purification technology and most patients require multiple consecutive TPEs. Regional citrate anticoagulation (RCA) could be used for membrane therapeutic plasma exchange (mTPE). However, there is no research on the metabolic complications of the RCA for patients receiving multiple consecutive mTPEs with fresh frozen plasma (FFP) as a replacement solution.</p><p><strong>Methods: </strong>We retrospectively included patients who used RCA for multiple consecutive mTPEs with FFP as a replacement solution in Xijing Hospital from 2020 to 2022. We collected blood gas analysis and electrolyte results before and after mTPE treatment and analysed the anticoagulation effectiveness and metabolic complications of the RCA.</p><p><strong>Results: </strong>A total of 33 patients who underwent 131 mTPE sessions were included, and 129 (98.5%) sessions were successfully completed. Severe hypocalcemia (19.1%) and metabolic alkalosis (58.5%) were frequently observed. In single mTPE sessions, there was a significant decrease in ionized calcium levels and significant increases in serum sodium, potassium, pH, bicarbonate, and base excess (BE) levels compared to pretreatment values. When comparing the values after the last treatment to the baseline values in all 33 patients, the serum sodium, pH, bicarbonate, and BE levels increased significantly, while the ionized calcium decreased significantly. The levels of pH, bicarbonate, and BE increased with the number of mTPE sessions, and the cumulative incidence of metabolic alkalosis reached 95.2% after the fifth treatment according to the Kaplan-Meier survival analysis.</p><p><strong>Conclusion: </strong>RCA is an effective anticoagulation method for patients undergoing mTPE with FFP as a replacement solution. However, the metabolic complications associated with RCA, especially hypocalcemia and metabolic alkalosis, frequently develop in patients who undergo multiple consecutive mTPEs with FFP.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: Effect of heart failure and atrial fibrillation on cardiorespiratory fitness in hemodialysis patients.","authors":"Muhammad Owais, Mansha Mansoor, Abdur Rehman","doi":"10.1007/s11255-024-04311-2","DOIUrl":"https://doi.org/10.1007/s11255-024-04311-2","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A potential therapeutic strategy using a miniature, implantable, wireless nerve stimulation device for treating stress urinary incontinence in rats.","authors":"Bohong Long, Chen Li, Han Deng, Haoyu Sun, Limin Liao, Xing Li","doi":"10.1007/s11255-024-04318-9","DOIUrl":"https://doi.org/10.1007/s11255-024-04318-9","url":null,"abstract":"<p><strong>Purpose: </strong>The present study examined the effects of a miniature, implantable, wireless stimulation device for treating stress urinary incontinence (SUI) in rats.</p><p><strong>Methods: </strong>Twenty-four female Sprague-Dawley rats were randomly assigned to three groups: Group 1 (Control), Group 2 (Sham), and Group 3 (Stimulation). All animals underwent vaginal distension (VD) to mimic postpartum SUI. Groups 2 and 3 were implanted with a stimulator in the pelvic floor muscle, but only Group 3 received continuous stimulation for two weeks. Multiple cystometrograms (CMGs) were performed to determine the leak point pressure (LPP) and maximal bladder capacity (MBC).</p><p><strong>Results: </strong>In the rat model, LPP in Group 1 after VD and after two weeks decreased significantly from baseline (21.1 ± 2.5 and 30.8 ± 5.2 vs. 52.5 ± 6.3 cmH₂O, P < 0.001). LPP improved after two weeks compared to after VD (P < 0.01), but did not return to baseline. In Group 2, LPP at baseline, after VD, and after two weeks were 50.8 ± 4.9, 23.1 ± 6.3, and 31.5 ± 6.9 cmH₂O, respectively, showing similar changes to Group 1. In Group 3, LPP values were 48.4 ± 4.8, 17.8 ± 3.9, and 48.4 ± 8.5 cmH₂O, with significant improvement after two weeks compared to after VD (P < 0.001), returning to baseline. MBC showed no significant differences across conditions.</p><p><strong>Conclusions: </strong>The current study demonstrated the effectiveness of the implantable stimulation device for treating SUI in a rat model. Further studies are needed to determine its long-term safety and action mechanism.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpression of BMAL-1 is related to progression of urothelial carcinoma in arsenic exposure area.","authors":"Yu-Jui Wu, Shu-Jyuan Chang, Yen-Shuo Huang, Chee-Yin Chai","doi":"10.1007/s11255-024-04320-1","DOIUrl":"https://doi.org/10.1007/s11255-024-04320-1","url":null,"abstract":"<p><strong>Background: </strong>Environmental exposure to arsenic has long been associated with various clinical and pathophysiological aspects of urothelial carcinoma (UC), although the role of arsenic in UC and its impact on circadian proteins, particularly BMAL-1, remains unestablished. Previous research suggests that arsenic upregulates Aurora kinase A (AURKA), subsequently inhibiting GSK-3β, which might lead to overexpression of BMAL-1; nevertheless, the underlying pathway and its clinical significance in UC with arsenic exposure have yet to be validated. This study focuses on two potential upstream regulators of BMAL-1, AURKA and GSK-3β.</p><p><strong>Methods: </strong>Ninety-nine tumor tissue samples were retrospectively collected along with their respective clinical data. Immunohistochemistry was employed to assess the expression of each protein.</p><p><strong>Results: </strong>A positive relationship was observed between the expression levels of AURKA and BMAL-1 (p < 0.001), while negative correlations were noted between the expression levels of GSK-3β and AURKA (p < 0.001), and between GSK-3β and BMAL-1 (p = 0.003). Tissue samples exposed to arsenic exhibited significantly higher levels of AURKA (p < 0.001) and BMAL-1 (p < 0.001), a markedly lower expression of GSK-3β (p = 0.001), alongside a decreased survival status (p = 0.025) compared to non-exposed samples. Furthermore, patients with UC of higher tumor grade tended to show increased levels of AURKA (p < 0.001), BMAL-1 (p < 0.001), and decreased levels of GSK-3β (p < 0.001). Elevated expression of AURKA (p < 0.001) and BMAL-1 (p = 0.002), as well as reduced expression of GSK-3β (p = 0.003), were also associated with a decreased survival status.</p><p><strong>Conclusions: </strong>This study highlights the differential expression of BMAL-1, AURKA, and GSK-3β in association with arsenic exposure and their significant impact on clinical and pathological features of UC. Moreover, BMAL-1, AURKA, and GSK-3β emerge as potential prognostic markers for UC in regions with arsenic exposure.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}