International Urology and Nephrology最新文献_第8页

Galectin-3: action and clinical utility in chronic kidney disease. Galectin-3：在慢性肾病中的作用和临床实用性。

IF 1.8 4区医学

International Urology and Nephrology Pub Date : 2024-11-01 Epub Date: 2024-06-11 DOI: 10.1007/s11255-024-04107-4

Gwyneth Syn, Yong Qin Lee, Zhen Yu Lim, Gek Cher Chan

{"title":"Galectin-3: action and clinical utility in chronic kidney disease.","authors":"Gwyneth Syn, Yong Qin Lee, Zhen Yu Lim, Gek Cher Chan","doi":"10.1007/s11255-024-04107-4","DOIUrl":"10.1007/s11255-024-04107-4","url":null,"abstract":"Chronic kidney disease is a significant cause of morbidity and mortality worldwide. In recent years, Galectin-3 has been put forward as a potential biomarker of chronic kidney disease progression. This review aims to assess the clinical utility of Galectin-3 in various pathological processes leading up to chronic kidney disease such as diabetes and lupus nephritis. We conducted a systematic search on PubMed from inception to September 2023, using the search term (\"Galectin-3\" OR \"gal-3\") AND (\"renal\" OR \"kidney\"). Galectin-3 has been shown to be both pro-fibrotic and protective against renal fibrosis through various mechanisms such as apoptotic body clearance and modulation of the Wnt pathway. Studies have found associations between raised Galectin-3, incidence and progression of chronic kidney disease. In lupus nephritis, Galectin-3 may serve as a biomarker for lupus nephritis activity. Although Galectin-3 inhibits cystogenesis, there is no correlation between total kidney volume and Galectin-3 in polycystic kidney disease. The role of Galectin-3 in staging and prognostication of renal cell carcinoma is yet to be determined. Galectin-3 has potential in predicting chronic kidney disease progression, in combination with other biomarkers. However, more trials are required given that present studies demonstrate conflicting results on the relationship between Galectin-3 and clinical outcomes in chronic kidney disease patients of varying aetiologies.","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3535-3543"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smoking is not associated with wound complications in augmented urethroplasty: a NSQIP analysis. 吸烟与增强尿道成形术的伤口并发症无关：NSQIP 分析。

IF 1.8 4区医学

International Urology and Nephrology Pub Date : 2024-11-01 Epub Date: 2024-05-30 DOI: 10.1007/s11255-024-04085-7

Ellen Cahill, Raeesa Islam, Kevin Chua, Vasundhara Balraj, Joseph Boyle, Hiren Patel, Alain Kaldany, Sai Krishnaraya Doppalapudi, Danielle Velez, Hari Tunuguntla, Joshua Sterling

{"title":"Smoking is not associated with wound complications in augmented urethroplasty: a NSQIP analysis.","authors":"Ellen Cahill, Raeesa Islam, Kevin Chua, Vasundhara Balraj, Joseph Boyle, Hiren Patel, Alain Kaldany, Sai Krishnaraya Doppalapudi, Danielle Velez, Hari Tunuguntla, Joshua Sterling","doi":"10.1007/s11255-024-04085-7","DOIUrl":"10.1007/s11255-024-04085-7","url":null,"abstract":"Objective: To investigate if predictors of wound complications differed between patients undergoing excision and primary anastomosis urethroplasty (EPA) and augmented urethroplasty.Methods: The National Surgical Quality Improvement Program database from 2006 to 2018 was queried for male patients undergoing urethroplasty. Thirty-day wound complications were identified and categorized (superficial/deep/organ-space surgical site infections and dehiscence). Multivariable logistic regression was performed to determine risk factors associated with wound complications. Smoking history was defined as current smoker within the past year.Results: Urethroplasty was performed in 2251 males, with 25.46% (n = 573) using a flap or graft. There was no significant difference in wound complications for patients undergoing augmented urethroplasty (n = 17, 2.97%) or EPA (n = 45, 2.68%) (p = 0.9). The augmented group had a higher BMI, longer operative time, and longer length of stay. On multivariable logistic regression, risk factors associated with wound complications for patients undergoing EPA were diabetes (OR 2.56, p = 0.03) and smoking (OR 2.32, p = 0.02). However, these factors were not associated with wound complications in patients undergoing augmented urethroplasty.Conclusions: Smoking and diabetes were associated with increased wound complications for men undergoing EPA, but not in patients undergoing augmented urethroplasty. Patients with comorbidities associated with worse wound healing may be more likely to have a wound complication when undergoing EPA.","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3479-3484"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of 11th rib excision on perioperative outcomes in patients undergoing partial nephrectomy for upper pole renal tumors. 第 11 肋切除术对上极肾肿瘤肾部分切除术患者围手术期预后的影响。

IF 1.8 4区医学

International Urology and Nephrology Pub Date : 2024-11-01 Epub Date: 2024-05-24 DOI: 10.1007/s11255-024-04087-5

Burhan Baylan, Abdullah Gurel

{"title":"The effect of 11th rib excision on perioperative outcomes in patients undergoing partial nephrectomy for upper pole renal tumors.","authors":"Burhan Baylan, Abdullah Gurel","doi":"10.1007/s11255-024-04087-5","DOIUrl":"10.1007/s11255-024-04087-5","url":null,"abstract":"Introduction: We aimed to evaluate the effect of eleven11th rib resection.on the perioperative period TRIFECTA criteria in patients who underwent retroperitoneal partial nephrectomy (PN) with the diagnosis of upper pole kidney tumors.Materials and methods: We conducted a retrospective analysis of the data of the patients who underwent Open PN for upper pole renal masses between 2018 and 2023. The patients were divided into two groups: PN with rib resection and PN without rib resection. The demographic characteristics, tumor sizes, PADUA scores, warm-cold renal ischemia times, mass excision and tumor bed suturing times, histopathological tumor type and surgical margin positivity of the patients were examined. Both groups were evaluated comparatively based on this data.Results: The renal nephrometry scores of the two groups were similar. The total renal ischemia time was significantly shorter in the patients who underwent a rib resection than in those who did not (p < 0.001). Both the tumor excision and tumor bed suturing times were significantly shorter in the group that underwent a rib resection than in the group that did not (p < 0.001). The Clavien-Dindo complication grades were statistically similar between the two groups.Conclusion: Complex in nature and high-risk renal masses located in the upper pole of the kidney, partial nephrectomy performed with an 11th rib resection can be considered a reliable surgical option with a shorter ischemia time, supporting the preservation of long-term renal function.","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3463-3468"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the lipid accumulation product index as a predictor for kidney stone prevalence: insights from NHANES 2007-2018. 评估作为肾结石患病率预测指标的脂质累积产物指数：2007-2018 年国家健康调查（NHANES）的启示。

IF 1.8 4区医学

International Urology and Nephrology Pub Date : 2024-11-01 Epub Date: 2024-06-13 DOI: 10.1007/s11255-024-04112-7

Ji Yan, Sen Li

{"title":"Evaluating the lipid accumulation product index as a predictor for kidney stone prevalence: insights from NHANES 2007-2018.","authors":"Ji Yan, Sen Li","doi":"10.1007/s11255-024-04112-7","DOIUrl":"10.1007/s11255-024-04112-7","url":null,"abstract":"Purpose: This study aimed to explore the relationship between the lipid accumulation product (LAP) index and kidney stone prevalence, utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2018.Methods: An observational study was executed employing the NHANES dataset from 2007 to 2018. Analytical methods encompassed multivariate logistic regression, restricted cubic splines (RCS), subgroup analysis, and interaction tests. Predictions were made using the receiver operating characteristic (ROC) curve and the area under the curve (AUC) values.Results: The analysis included 9744 adults aged 20 years and older. Multivariate logistic regression identified a significant positive association between log2-transformed LAP (treated as a continuous variable) and kidney stone risk across all models, with odds ratios (ORs) exceeding 1 and p values less than 0.001. Categorically, ORs escalated with increasing LAP levels, indicating a dose-response relationship. The RCS analysis confirmed a linear positive correlation between log2-transformed LAP and kidney stone risk. Subgroup analyses revealed that the log2-transformed LAP-kidney stones relationship was consistent, unaffected by stratification across the examined variables. In addition, LAP index (AUC = 0.600) proved to be a more effective predictor of kidney stones compared to body mass index (AUC = 0.584).Conclusion: Elevated LAP levels are positively correlated with a higher incidence of kidney stones, signifying its potential as a risk marker for this condition. Future research should investigate the mechanisms underlying this relationship. LAP can be used as a new anthropometric index to predict kidney stones, and its predictive ability is stronger than body mass index.","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3639-3645"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of single nucleotide genetic polymorphisms of vitamin D receptor and calcium-sensitive receptor with calcium-containing kidney stones in Chinese Dai populations: a prospective multi-center study. 中国傣族人群维生素 D 受体和钙敏感受体的单核苷酸基因多态性与含钙肾结石的关系：一项前瞻性多中心研究。

IF 1.8 4区医学

International Urology and Nephrology Pub Date : 2024-11-01 Epub Date: 2024-06-17 DOI: 10.1007/s11255-024-04109-2

Ji Li, Kunbin Ke, Baiyu Zhang, Yidao Liu, Jing Bai, Mengyue Wang, Hao Li

{"title":"Association of single nucleotide genetic polymorphisms of vitamin D receptor and calcium-sensitive receptor with calcium-containing kidney stones in Chinese Dai populations: a prospective multi-center study.","authors":"Ji Li, Kunbin Ke, Baiyu Zhang, Yidao Liu, Jing Bai, Mengyue Wang, Hao Li","doi":"10.1007/s11255-024-04109-2","DOIUrl":"10.1007/s11255-024-04109-2","url":null,"abstract":"Purpose: To evaluate the association between vitamin D receptor (VDRs) and calcium-sensitive receptor (CaSR) gene polymorphisms and calcium-containing kidney stones (CCKS) in Dai populations.Methods: A total of 160 CCKS patients and 87 healthy controls were included in this study. CCKS was confirmed using urological computed tomography (CT), plain abdominal radiograph, or surgical lithotomy. Stone samples obtained during surgery were analyzed using infrared spectroscopy. Venous blood and 24-h urine samples were collected and analyzed using Sanger sequencing and high-performance liquid chromatography, respectively. Genetic variants in the VDR gene (rs7975232, rs2228570, rs731236, and rs1544410) and CaSR gene (rs7652589, rs1801725, and rs1042636) were identified through sequence analysis.Results: Analysis of genotype and allele frequencies revealed that the rs7975232 polymorphism in the VDR gene and the rs7652589 allele in the CaSR gene were significantly associated with CCKS. Furthermore, patients carrying the AC and AA genotypes of rs7975232 showed a higher incidence of hypocitraturia compared to those with other genotypes (p < 0.05). The AA and GG genotypes of rs1042636 and the AA genotype of rs7652589 were significantly associated with hypercalciuria (p < 0.05).Conclusion: CCKS in this study population may be closely related to hypocitraturia caused by the VDR locus rs7975232 polymorphism and hypercalciuria caused by the CaSR locus rs1042636 and rs7652589 polymorphism.","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3647-3655"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five-year survival analysis and predictors of mortality of adult hemodialysis patients in Indonesia: a nationwide database analysis. 印度尼西亚成年血液透析患者的五年生存分析和死亡率预测因素：全国数据库分析。

IF 1.8 4区医学

International Urology and Nephrology Pub Date : 2024-11-01 Epub Date: 2024-06-19 DOI: 10.1007/s11255-024-04118-1

Metalia Puspitasari, Afiatin, Vicka Oktaria, Yulia Wardhani, Wynne Wijaya

{"title":"Five-year survival analysis and predictors of mortality of adult hemodialysis patients in Indonesia: a nationwide database analysis.","authors":"Metalia Puspitasari, Afiatin, Vicka Oktaria, Yulia Wardhani, Wynne Wijaya","doi":"10.1007/s11255-024-04118-1","DOIUrl":"10.1007/s11255-024-04118-1","url":null,"abstract":"Background: Hemodialysis (HD) is the modality of renal replacement therapy (RRT) with the highest mortality rate. The identification of prognostic factors will help achieve better outcomes among HD patients. In this study, we sought to conduct a survival analysis and determine the predictors of mortality among adult Indonesian HD patients using data obtained from Indonesian Renal Registry (IRR).Methods: This is a retrospective cohort study which reviewed all adult hemodialysis patients in Indonesia based on the records of IRR during 2007-2022. Variables analyzed in this study include age, sex, etiology of CKD, cause of death, HD frequency, and initial vascular access. A 5-year follow-up was performed until the outcome of death or drop out was found.Results: Among 99,552 eligible patients, the mean survival length was 1536.21 ± 2.50 days. The 5-year survival rate was 77%. Cox proportional hazard regression model revealed demographic and clinical characteristics that are significantly associated with mortality: male sex (HR: 1.038, 95% CI 1.002-1.075), age of 60 years or older (HR: 1.329, 95% CI 1.281-1.379), diabetic nephropathy (HR: 1.347, 95% CI 1.249-1.452), twice-weekly hemodialysis frequency (HR: 1.080, 95% CI 1.011-1.155), initial vascular accesses with femoral vein puncture (HR: 2.710, 95% CI 2.568-2.860), and CVC (HR: 2.992, 95% CI 2.848-3.144).Conclusions: The 5-year survival rate of Indonesian HD patients is 77. Male sex, age of HD onset at 60 years or older, diabetic nephropathy, twice-weekly HD frequency, and the initial vascular accesses with femoral vein puncture and CVC are associated with increased risk of mortality.","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3657-3664"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contrast-enhanced ultrasound (CEUS) as a follow-up method after the focal treatment of renal tumors: systematic review and meta-analysis. 对比增强超声（CEUS）作为肾肿瘤病灶治疗后的随访方法：系统综述和荟萃分析。

IF 1.8 4区医学

International Urology and Nephrology Pub Date : 2024-11-01 Epub Date: 2024-06-08 DOI: 10.1007/s11255-024-04102-9

Stanislav Vovdenko, Stanislav Ali, Hussein Ali, Mark Taratkin, Andrey Morozov, Aleksandr Suvorov, Diana Khabib, Leonid Rapoport, Evgeny Bezrukov

{"title":"Contrast-enhanced ultrasound (CEUS) as a follow-up method after the focal treatment of renal tumors: systematic review and meta-analysis.","authors":"Stanislav Vovdenko, Stanislav Ali, Hussein Ali, Mark Taratkin, Andrey Morozov, Aleksandr Suvorov, Diana Khabib, Leonid Rapoport, Evgeny Bezrukov","doi":"10.1007/s11255-024-04102-9","DOIUrl":"10.1007/s11255-024-04102-9","url":null,"abstract":"Context: Contrast-enhanced ultrasound (CEUS) is a cost-effective radiation-free diagnostic method that can be used for renal tumor postoperative visualization after ablative treatment.Objective: To assess CEUS diagnostic accuracy comparing with CT and MRI as a follow-up method in short-term and long-term postoperative periods after renal tumor ablation.Materials and methods: A systematic review and meta-analysis were performed in Scopus and Medline databases using the query \"(kidney OR rena* OR RCC) AND (ablation OR RFA OR MWA OR cryo*) AND CEUS\". The endpoint of the study was the evaluation of the overall accuracy of CEUS.Results: Twelve trials were included in the review. With CT or MRI as a reference, for a short-term group (< 6 weeks after ablation) pooled sensitivity was 90.2%, I2 = 0%; pooled specificity was 99.3%, I2 = 0%; pooled NPV was 98.6%, I2 = 0%; pooled PPV was 94.6%, I2 = 0%; the AUC on the SROC curve was 0.971. For the long-term group (> 6 weeks after ablation), pooled sensitivity was 95.3%, I2 = 0%; pooled specificity was 97.6%, I2 = 0%; PPV was 74.2%, I2 = 4%; NPV was 99.4%, I2 = 5%; AUC = 0.93.Conclusion: CEUS has high sensitivity and specificity in ruling out the presence of local recurrence after renal tumor ablation with a higher risk of false-positive results within follow-up > 6 weeks compared with that for CT or MRI. Further studies with a unified protocol and morphological control of local renal tumor recurrence after ablation are needed.","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3415-3426"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urological evaluation in a case of neuro-Behcet's syndrome from India. 印度一例神经-贝赫切特综合征患者的泌尿系统评估。

IF 1.8 4区医学

International Urology and Nephrology Pub Date : 2024-11-01 Epub Date: 2024-07-04 DOI: 10.1007/s11255-024-04135-0

Ekansh Gupta, Madhumohan R Prabhudesai, Guruprasad Guruprasad, Mohammad Arham Mateen, Ritvij Patankar, Nilesh Talwadkar

引用次数: 0

Serum bicarbonate levels, kidney injury progression, and overall survival: which came first, the chicken or the egg? 血清碳酸氢盐水平、肾损伤进展和总生存期：先有鸡还是先有蛋？

IF 1.8 4区医学

International Urology and Nephrology Pub Date : 2024-11-01 Epub Date: 2024-06-17 DOI: 10.1007/s11255-024-04120-7

Domenico Cozzo, Nathalie Merkel, Antonio Bellasi

引用次数: 0

Are inorganic nitrates the key to preventing contrast-induced nephropathy? 无机硝酸盐是预防造影剂诱发肾病的关键吗？

IF 1.8 4区医学

International Urology and Nephrology Pub Date : 2024-11-01 Epub Date: 2024-06-17 DOI: 10.1007/s11255-024-04123-4

Asad Gul Rao, Mahek Kataria, Ghazal Ishaque

引用次数: 0