International Urology and Nephrology最新文献

{"title":"Correction: Concerns regarding the prognostic validity and analytical coherence of total protein-to-albumin ratio in diabetic kidney disease.","authors":"Ayesha Abbas, Syed Hassan Mohi Ud Din Gillani, Ahmed Atef Najm, Mohammad Mujtaba Khokhar, Muhammad Saeed Qazi","doi":"10.1007/s11255-025-04818-2","DOIUrl":"https://doi.org/10.1007/s11255-025-04818-2","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10-year oncological outcomes of EBRT versus HIFU for stage II prostate cancer: a multicenter Chang Gung research database (CGRD) study with inverse-probability-of-treatment weighting (IPTW) analysis.","authors":"Hsing-Tsuo Yeh, Yi-Yang Liu, Yin Lun Chang, Hui-Ying Liu, Yuan-Chi Shen, Hung-Jen Wang, Yen-Ta Chen, Yao-Chi Chuang, Hao-Lun Luo","doi":"10.1007/s11255-025-04805-7","DOIUrl":"https://doi.org/10.1007/s11255-025-04805-7","url":null,"abstract":"<p><strong>Background: </strong>To evaluate oncological outcome of external beam radiation therapy(EBRT) versus high-intensity focused ultrasound (HIFU) in patients with stage II prostate cancer.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed patients with stage II prostate cancer from the Chang Gung Research Database spanning the years 2005 to 2022. Inverse probability of treatment weighting (IPTW) method was performed to achieve baseline equivalence. Oncology outcomes including overall survival (OS) and cancer specific survival (CSS) were assessed using Kaplan-Meier curves before and after IPTW adjustment. Subgroup analysis of stage IIa, IIb, and IIc were also conducted. We use cox proportional hazards analyses to further evaluate the association between treatment and survival outcomes.</p><p><strong>Results: </strong>Total of 176 EBRT and 244 HIFU procedures were identified. EBRT group has higher overall mortality (9.2% compared to 16.7% after IPTW; standardized difference 0.224) and cancer specific mortality (5.4% compared to 9.2% after IPTW; standardized difference 0.144) after IPTW adjustment. An overall survival benefit is observed in the HIFU group for all stage II prostate cancer cases, with a particularly significant advantage in the stage IIa subgroup after IPTW adjustment (p = 0.032). Although the cancer-specific survival benefit slightly favors the HIFU stage IIa subgroup after IPTW adjustment, it does not reach statistical significance (p = 0.069). EBRT is associated with significantly worse OS compared to HIFU across univariate, multivariate, and IPTW-adjusted Cox regression models, with hazard ratios ranging from 2.03 to 2.63 (all p 0.05). However, for CSS, a significant difference was found only in the univariate model (HR = 2.38, p = 0.032), and this association was not maintained after adjustment.</p><p><strong>Conclusions: </strong>HIFU demonstrates non-inferior overall survival and cancer specific survival compared to EBRT in patients with stage II prostate cancer, particularly in the stage IIa subgroup after more than 10 years of follow-up. Further randomized prospective studies are needed to evaluate the oncological outcomes of different prostate cancer treatment modalities.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erectile dysfunction following prostate biopsy: a comparative analysis of transrectal versus transperineal approaches.","authors":"O Ermis, M G Sonmez, A Tozsin, M S Iyisoy, M Yilmaz, G Sonmez, O O Cakir, A Aydin, L Tunc, E Barret, T Herrmann, K Ahmed, S Guven","doi":"10.1007/s11255-025-04816-4","DOIUrl":"https://doi.org/10.1007/s11255-025-04816-4","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Erectile dysfunction (ED) is a concern for men undergoing prostate biopsy. With the increasing adoption of transperineal (TP) biopsy over transrectal (TR) biopsy, it remains unclear which approach carries a lower risk of erectile dysfunction. This study aims to be the first meta-analysis to evaluate erectile dysfunction following TR versus TP prostate biopsy at 1, 3 and 6 months intervals, thereby providing clinicians with evidence-based guidance for patient counseling and shared decision-making.</p><p><strong>Materials and methods: </strong>This review was prospectively registered on PROSPERO (CRD42024541557) and followed PRISMA guidelines, with searches conducted in PubMed, Scopus, and the Cochrane Library databases up to July 2024. A total of 22 studies reporting erectile function outcomes (IIEF scores) at baseline and 1, 3 and 6 months post-biopsy were identified. After applying inclusion and exclusion criteria, 12 studies were included in the final meta-analysis. TR and TP biopsy methods were compared using a random-effects model to assess standardized mean differences (SMD) in erectile function at each follow-up point. The risk of bias for each study was evaluated to ensure result reliability.</p><p><strong>Results: </strong>At 1 month follow-up, a significant decline in erectile function was observed overall (SMD: - 0.3785, p = 0.038). The TP approach showed a slightly more significant decline than the TR approach; however, this difference was not statistically significant (p = 0.074). At 3 months follow-up, no significant differences were observed between methods overall (SMD: - 0.1663, p = 0.132), although TP biopsy alone showed a modest yet considerable decline (SMD: - 0.1868, p = 0.03). At 6 months, erectile function had generally returned to baseline, with no significant differences observed between biopsy techniques (p = 0.41).</p><p><strong>Conclusion: </strong>Both TR and TP prostate biopsies are associated with a transient decline in erectile function. These effects typically resolve by 6 months in most patients, with no significant long-term impact observed. While the initial functional impact may be slightly greater with the TP technique, this difference attenuates over time. These findings are crucial for managing patient expectations post-biopsy.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative digital pathology reveals morphological and molecular correlates of tumor aggressiveness in prostate cancer.","authors":"Francisco Araujo, Guilherme Velozo, Juliana Cordeiro, Aline Ramos, Samuel Ferreira, Laura Cardoso, Vania Melo, Fábio Távora","doi":"10.1007/s11255-025-04806-6","DOIUrl":"https://doi.org/10.1007/s11255-025-04806-6","url":null,"abstract":"<p><p>Digital pathology enables objective evaluation of prognostic markers in prostate cancer through integrated morphological and molecular analysis. In this study, 72 radical prostatectomy samples were analyzed using tissue microarrays and whole-slide imaging, with tumor regions annotated by pathologists and quantified in QuPath for PTEN, Ki-67, ATM, CD8, and key histological features. PTEN quantification showed high variability and limited predictive value (AUC <math><mo>=</mo></math> 0.61). Cribriform morphology was significantly associated with advanced pathological stage, non-organ-confined tumors, and a profile of aggressiveness markers, whereas CD8 <math><mmultiscripts><mrow></mrow> <mrow></mrow> <mo>+</mo></mmultiscripts> </math> density did not correlate, supporting an \"immune-cold\" phenotype. Quantitative cribriform area did not add prognostic value. A logistic regression model combining Gleason pattern 4 percentage and ATM expression predicted cribriform morphology with good accuracy (AUC <math><mo>=</mo></math> 0.79). These results highlight the potential of digital pathology to refine risk stratification and identify high-risk morpho-molecular features in prostate cancer.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of a flexible and navigable suction ureteral access sheath vs. a conventional intelligent pressure-control sheath in retrograde intrarenal surgery for infection-related renal calculi.","authors":"Jianrong Huang, Chuance Du, Qiliang Zhai, Hailin Luo, Xiaolong He","doi":"10.1007/s11255-025-04783-w","DOIUrl":"https://doi.org/10.1007/s11255-025-04783-w","url":null,"abstract":"<p><strong>Background: </strong>This study attempts to evaluate the clinical performance and safety of a front-end flexible intelligent pressure-control ureteral access sheath (FT-IPC UAS) in retrograde intrarenal surgery (RIRS) for infection-related renal calculi. This research also aims to develop a predictive model for postoperative infection.</p><p><strong>Methods: </strong>A total of 124 patients with renal calculi were prospectively enrolled and randomly assigned in a 1:1 ratio to the observation group (FT-IPC UAS) or the control group (conventional sheath). The primary endpoint was the 1-month stone-free rate (SFR). Intraoperative parameters, postoperative recovery outcomes, calculi-free rates, complication rates, and incidence of infection were compared. Logistic regression analysis was adopted to identify independent risk factors for postoperative infection. A multivariable prediction model was constructed and evaluated using receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and the Hosmer-Lemeshow goodness-of-fit test.</p><p><strong>Results: </strong>The calculi-free rate was also higher in the observation group, while the infection rate was markedly lower. The observation group demonstrated significantly shorter surgery time, lower peak perfusion pressure, improved surgical field visibility, and declined postoperative inflammatory markers (all p < 0.001). Patients in the observation group experienced faster recovery. Multivariate regression analysis identified procalcitonin (PCT) > 0.5 ng/mL as an independent risk factor for postoperative infection. The combined prediction model yielded an AUC of 0.8055, indicating good predictive performance.</p><p><strong>Conclusions: </strong>The FT-IPC UAS enhances surgical efficiency, accelerates recovery, and reduces infection risk during RIRS. The predictive model incorporating PCT, sheath type, and surgery time offers reliable guidance for postoperative infection.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional management of chronic kidney disease in children: a best evidence summary.","authors":"Diyi Luo, Lili Liu, Shenghua Zhang, Yujia Guan, Jingyi He","doi":"10.1007/s11255-025-04802-w","DOIUrl":"https://doi.org/10.1007/s11255-025-04802-w","url":null,"abstract":"<p><strong>Objective: </strong>Chronic kidney disease in children is increasingly prevalent worldwide and significantly impacts quality of life. Nutritional management is one of the key components in the comprehensive treatment of chronic kidney disease in children; however, the relevant contents are scattered. This study summarizes the best evidence on nutritional management of chronic kidney disease in children, to provide high-quality evidence-based references for clinical practice.</p><p><strong>Methods: </strong>By following the \"6S\" pyramid model, top-down searches were conducted in computerized decision support systems, international guideline websites, websites of chronic kidney disease professional associations, and various databases. The timeframe for the search was from the inception of the databases to September 2024. The quality evaluation, extraction, and synthesis of the evidence were conducted independently by 2 researchers.</p><p><strong>Results: </strong>A total of 26 articles were included, including 8 guidelines, 1 expert consensus, 5 clinical decisions, 11 recommendation for clinical practice, and 1 systematic review. Thirty-five pieces of best evidence were synthesized into 6 categories, including nutrition management team, nutrition screening and assessment, nutrition diagnosis, nutrition goals, nutrition support, nutrition monitoring, and follow-up.</p><p><strong>Conclusion: </strong>The best evidence for nutritional management of chronic kidney disease in children in this study is clinically practical, can provide evidence-based support for medical staff to implement nutritional management measures and improve clinical outcomes in children with chronic kidney disease.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the efficacy of modified laparoscopic ureterobladder reimplantation in the treatment of ureterovaginal fistula.","authors":"Ruizhe Jiang, Chao Jiang, Shiji Li, Tengfei Zhu, Lu Fang, Chao Yang, Yi Wang","doi":"10.1007/s11255-025-04504-3","DOIUrl":"10.1007/s11255-025-04504-3","url":null,"abstract":"<p><strong>Objective: </strong>Analysis of technical improvements and efficacy of modified laparoscopic ureteral bladder reimplantation for the treatment of ureterovaginal fistula.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on clinical data from 20 patients who developed a ureterovaginal fistula due to gynecological surgeries and underwent modified laparoscopic ureteral bladder reimplantation at our hospital from September 2018 to May 2024.</p><p><strong>Results: </strong>20 patients with ureterovaginal fistula were included, with 9 cases on the left side, 9 on the right side, and 2 bilateral. The locations of the ureterovaginal fistulas were all in the distal ureter. The average age was 50.24 ± 5.22 years, and the average body mass index was 23.22 ± 3.98. The average duration of urine leakage before surgery was 12.20 ± 7.05 days. All surgeries were successful (20/20), with an average operation time of 140.85 ± 55.80 min, intraoperative blood loss of 14.50 ± 7.42 ml, and postoperative hospital stay of 8.24 ± 4.47 days. The ureteral stents were left in place for a mean duration of (51.50 ± 9.65) days postoperatively. No complications occurred after the surgery, and imaging follow-up at 9 months indicated that all patients had recovered well.</p><p><strong>Conclusion: </strong>Early diagnosis and treatment are essential for patients with ureterovaginal fistula. During the modified ureteral bladder reimplantation, it is crucial to ensure tension-free anastomosis without excessive dissection of the distal ureter. Laparoscopic ureteral bladder reimplantation is a reliable, safe, minimally invasive, and well-accepted surgical method, deserving of further promotion.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3233-3237"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends in heart failure and acute kidney injury-related mortality in the U.S.: a 21-year retrospective analysis of the CDC WONDER database.","authors":"Rayyan Nabi, Muzamil Akhtar, Shree Rath, Hanzala Ahmed Farooqi, Abdul Raffay Awais, Sabahat Ul Ain Munir Abbasi, Saeed Ahmed, Peter Collins, Raheel Ahmed, Tabeer Zahid, Zahid Nabi","doi":"10.1007/s11255-025-04534-x","DOIUrl":"10.1007/s11255-025-04534-x","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) and acute kidney injury (AKI) are leading contributors to morbidity and mortality in the United States, often coexisting as part of the cardiorenal syndrome. Understanding long-term mortality trends is crucial for guiding healthcare policies and interventions. This study analyses national trends in HF- and AKI-related mortality from 1999 to 2020, with a focus on age-adjusted mortality rates (AAMR) and disparities across gender, race/ethnicity, urbanization, and geographic regions.</p><p><strong>Methods: </strong>We conducted a retrospective analysis using the CDC WONDER database, extracting mortality data for adults aged 25-85 years. HF- and AKI-related deaths were identified using ICD-10 codes. Temporal trends in AAMR were evaluated using Joinpoint regression, and subgroup analyses were performed to assess disparities.</p><p><strong>Results: </strong>A total of 219,243 HF- and AKI-related deaths were recorded. The overall AAMR increased from 3.56 per 100,000 in 1999 to 5.30 in 2020 (AAPC: 1.52%; p < 0.001). Males had a higher AAMR than females (5.80 vs. 3.84). NH Black individuals exhibited the steepest rise in mortality, whereas NH White and Asian populations showed stabilization. Nonmetropolitan areas had higher AAMRs compared to metropolitan regions. State-level disparities revealed that North Dakota and West Virginia had the highest mortality rates, whereas Florida and Arizona had the lowest.</p><p><strong>Conclusion: </strong>HF- and AKI-related mortality has risen significantly over the past two decades, with pronounced disparities across demographic and geographic subgroups. These findings underscore the need for targeted interventions to address healthcare inequities and improve outcomes in high-risk populations.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3399-3408"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the gut microbiome with diabetic nephropathy and the mediated effect of metabolites: friend or enemy?","authors":"Yunfeng Yu, Xinyu Yang, Juan Deng, Yuman Yin, Yongjun Wu, Rong Yu","doi":"10.1007/s11255-025-04519-w","DOIUrl":"10.1007/s11255-025-04519-w","url":null,"abstract":"<p><strong>Objective: </strong>The effects of gut microbiome and its metabolites on diabetic nephropathy (DN) have been inadequately elucidated. The aim of this study is to assess the causal effect of gut microbiome on DN and the mediated effect of metabolites by a two-step Mendelian randomization (MR).</p><p><strong>Methods: </strong>Datasets of gut microbiome, metabolites, and DN were acquired in genome-wide association studies and screened for single nucleotide polymorphisms according to the underlying assumptions of MR. Subsequently, inverse variance weighted was used as the primary method for MR analysis to assess the causal effect of gut microbiome on DN and the mediated effect of metabolites. Finally, MR-Egger intercept, Cochran's Q test, and leave-one-out sensitivity analysis were used to assess the horizontal pleiotropy, heterogeneity, and robustness of the results, respectively.</p><p><strong>Results: </strong>The MR analysis demonstrated that Parabacteroides merdae increased the genetic susceptibility to DN by reducing acetylcarnitine (C2) to propionylcarnitine (C3) ratio (mediated proportion 8.95%, mediated effect 0.024) and alpha-ketobutyrate to 3-methyl-2-oxovalerate ratio (mediated proportion 19.90%, mediated effect 0.053). MR Egger showed that these results lack horizontal pleiotropy (p ≥ 0.05). Cochran's Q and sensitivity analysis suggested these results had no heterogeneity (p ≥ 0.05) and were robust.</p><p><strong>Conclusion: </strong>Our findings revealed the pathway by which Parabacteroides merdae increased the genetic susceptibility to DN by regulating acetylcarnitine (C2) to propionylcarnitine (C3) ratio and alpha-ketobutyrate to 3-methyl-2-oxovalerate ratio. It provides new genetic insights for understanding the pathogenesis of DN and related drug research.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3373-3385"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Optilume drug-coated balloon dilation compromise female sphincter function?","authors":"Lukas Andrius Jelisejevas, Gennadi Tulchiner, Patricia Kink, Peter Rehder","doi":"10.1007/s11255-025-04513-2","DOIUrl":"10.1007/s11255-025-04513-2","url":null,"abstract":"<p><strong>Purpose: </strong>Female urethral strictures (FUS) are rare, yet when present very bothersome. Repeated dilation often results in recurrence, requiring surgical urethral reconstruction in the long term. We assessed the outcomes of female patients with urethral stricture disease undergoing Optilume drug-coated-balloon (DCB) dilation.</p><p><strong>Methods: </strong>Between August 2021 and May 2024, 14 female patients with FUS underwent DCB dilation. Two transgender male-to-female patients were excluded. The diagnosis was confirmed by inability to pass a 14Fr catheter, translabial ultrasound or voiding cystourethrogram (VCUG). Exclusion criteria were urinary tract infection, neurological disease and previous urethroplasty. Written consent was obtained prior to intervention and included the option of urethroplasty. After hydrophilic urethral dilation, urethrocystoscopy was performed. DCB (5 cm) dilation was done to 30Fr at 10 bar for 10 min. General or local anaesthesia was used depending on patient's preference. Transurethral catheter was placed for 2-5 days. Endpoints were urinary continence, anatomical success (≥ 14Fr by cystoscopy/calibration) and freedom from repeat intervention at 6 months.</p><p><strong>Results: </strong>The mean age was 52.3 years (range: 31-81), the mean number of prior interventions was 4.3 (range: 0-40). The mean follow-up was 12 months (range: 6-41). At the time of analysis, 11 out of 12 subjects (91.7%) were free from recurrence and repeat intervention. All patients remained continent after the intervention, with two reporting complete resolution of preexisting incontinence. Limitations of the study include the small sample size, short follow-up and single centre nature.</p><p><strong>Conclusions: </strong>Optilume DCB dilation demonstrates short-term efficacy, is well tolerated, safe, and notably preserves sphincter function.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"3215-3217"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}