International Urology and Nephrology最新文献

{"title":"Association between Chinese visceral adiposity index and cardiovascular events risk in individuals with cardiovascular-kidney-metabolic syndrome stage 0-3: a nationwide cohort study.","authors":"Xiaobo Shen, Qi Liu, Tianchen Lin, Danna Zheng, Qiang He","doi":"10.1007/s11255-025-04403-7","DOIUrl":"https://doi.org/10.1007/s11255-025-04403-7","url":null,"abstract":"<p><strong>Background: </strong>The population with cardiovascular-kidney-metabolic (CKM) syndrome has a higher risk of cardiovascular events. Chinese visceral adiposity index (CVAI), an index of both visceral obesity and surrogate insulin resistance, has been linked to cardiovascular events. However, the nature of this relationship remains unclear in individuals with CKM syndrome.</p><p><strong>Methods: </strong>All data came from the China Health and Retirement Longitudinal Study (CHARLS). The association between CVAI and cardiovascular events risk was explored using Cox regression models, restricted cubic spline (RCS) curves, and multiple sensitivity analyses. To compare the predictive abilities of various indices, receiver operating characteristic (ROC) analyses were employed.</p><p><strong>Results: </strong>7744 participants were in final analysis. During 9 year follow-up, 1679 cases of cardiovascular disease (CVD), 1,255 cases of heart disease, and 604 cases of stroke were recorded. Cox regression analyses revealed that per-SD (standard deviation) increase in CVAI, the risk of CVD, heart disease, and stroke increased by 22% (95% CI 1.13-1.32), 22% (95% CI 1.13-1.32), and 32% (95% CI 1.19-1.47). In participants at CKM stage 3 with CVD, a J-shaped curve was observed in the RCS analyses (P non-linearity = 0.036). Subgroup analysis revealed an interaction between age and each 10-unit increase in CVAI in CVD (P interaction = 0.0173) and stroke risk (P interaction = 0.028). The AUC (area under curve) value for CVAI was highest compared to other indicators (all DeLong Test P values < 0.05).</p><p><strong>Conclusions: </strong>This research demonstrates a higher CVAI was linked to increased cardiovascular risk in individuals with CKM syndrome stage 0-3. Monitoring CVAI can help identify high-risk individuals early and improve the effectiveness of disease management.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of nicorandil for prevention of contrast-induced nephropathy in patients undergoing coronary procedures: a systematic review and meta-analysis.","authors":"Ayesha Imran Butt, Fazila Afzal, Sukaina Raza, F N U Namal, Dawood Ahmed, Hassaan Abid, Muhammad Hudaib, Zainab Safdar Ali Sarwar, Soha Bashir, Asadullah Khalid, Umer Hassan, Mohammad Ebad Ur Rehman, Huzaifa Ahmad Cheema, Ali Husnain, Usama Anwar, Muhammad Mohid Tahir, Adeel Ahmad, Wajeeh Ur Rehman, Raheel Ahmed","doi":"10.1007/s11255-025-04409-1","DOIUrl":"https://doi.org/10.1007/s11255-025-04409-1","url":null,"abstract":"<p><strong>Background: </strong>Contrast-induced nephropathy (CIN) is a potentially serious complication of intravenous or intra-arterial contrast administration during angiographic procedures that results in renal dysfunction. CIN can increase the risk of mortality by three-fold. This meta-analysis assesses the efficacy and safety of nicorandil for the prevention of CIN in patients undergoing percutaneous coronary intervention (PCI) or coronary angiography (CAG).</p><p><strong>Methods: </strong>Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and ClinicalTrials.gov were used to perform a thorough literature search from their inception to July 2024. Twelve randomized controlled trials (RCTs) were included. A random-effects meta-analysis was performed on RevMan and pooled estimates were presented as forest plots. The Mantel-Haenszel method was used for dichotomous outcomes and risk ratios (RRs) were calculated along with 95% confidence intervals (95% CI).</p><p><strong>Results: </strong>This meta-analysis included 2787 participants (nicorandil: 1418, control: 1394). The use of nicorandil was protective against CIN (RR 0.38, 95% CI 0.29-0.50). There was no significant difference in major adverse events between the groups (RR 0.77, 95% CI 0.52-1.13, p = 0.18). Similarly, the use of nicorandil did not affect the risk of developing stroke (RR 1.05, 95% CI: 0.38-2.95), myocardial infarction (RR 0.90, 95% CI: 0.56-1.43), heart failure (RR 0.81, 95% CI: 0.39-1.68), cardiac death (RR 0.90, 95% CI: 0.28-2.88) and dialysis (RR 0.70, 95% CI: 0.11-4.44).</p><p><strong>Conclusion: </strong>This meta-analysis concludes that nicorandil reduces CIN incidence after PCI or CAG without significantly increasing major adverse events. However, further well-designed, large-scale RCTs are needed to strengthen the practical relevance before routine clinical use.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the peripheral nature of persistent sexual dysfunction associated with post-finasteride, post-SSRI and post-accutane syndromes: lessons learned from a case study.","authors":"Jackson Stachelek, Bernadette M M Zwaans, Roni Shtein, Kenneth M Peters","doi":"10.1007/s11255-025-04373-w","DOIUrl":"https://doi.org/10.1007/s11255-025-04373-w","url":null,"abstract":"<p><strong>Purpose: </strong>Retinoids for acne, finasteride/saw palmetto for hair loss/BPH, and selective Serotonin Reuptake inhibitors (SSRIs) for depression, have all been implicated in severe, persistent sexual dysfunction that occurs after stopping these medications. The underlying mechanism of this post-drug syndrome is unknown, nor is an effective treatment available. The purpose of this investigation is to use a retrospective chart review to characterize a cohort of patients who suffer from post-drug syndrome and to determine if improvement in symptoms is feasible when focusing treatment on the peripheral nerves of the genitalia.</p><p><strong>Methods: </strong>Three male patients seen in our urology clinic were sequentially treated with high frequency electrical stimulation and low intensity extracorporeal shock wave therapy for a total of 16 weeks. Symptom improvement was assessed using the International Index of Erection Function (IIEF), the Masturbation Erection Index (MEI), global response assessment scale, corneal confocal microscopy, the FirmTech® Ring to monitor nocturnal erections pre- and post-peripheral nerve treatment and von Frey filament testing.</p><p><strong>Result: </strong>Mild-moderate erectile function improvement, mild penile sensitivity improvement, and mild nocturnal erection improvement were seen across all three patients. Peripheral neuropathy was noted in two patients via corneal confocal microscopy, however central symptoms remain.</p><p><strong>Conclusion: </strong>The post-drug syndrome appears to consist of a peripheral component which may be treatable using our regimen, as we saw overall improvement in penile sensitivity and erections following treatments. However, patients were still profoundly affected by their symptoms post-treatment and thus there is an urgent need for additional research on this syndrome.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-intensity extracorporeal shockwave therapy in patients with diabetic kidney disease: a matched cohort study.","authors":"Sofus Valentin Vestersager, Sune Moeller Skov-Jeppesen, Knud Bonnet Yderstraede, Claus Bistrup, Boye L Jensen, Lars Lund","doi":"10.1007/s11255-025-04379-4","DOIUrl":"https://doi.org/10.1007/s11255-025-04379-4","url":null,"abstract":"<p><strong>Purpose: </strong>Low-intensity extracorporeal shockwave therapy (LI-ESWT) is a potential novel treatment against diabetic kidney disease (DKD). The present study investigates the longer term effects of LI-ESWT on kidney function in patients with DKD.</p><p><strong>Methods: </strong>This matched cohort study included 28 patients with DKD, who received six sessions of LI-ESWT. Patients were matched 1:5 with patients from the Funen Diabetes Database. Multivariable adjusted eGFR and ACR were analyzed using multilevel mixed-effects linear regression. The primary outcomes were ACR and eGFR measured at 3, 6, 12, and 18 month follow-up. Secondary analyses with patients stratified for sex, age, baseline eGFR, and baseline ACR were made for the multivariable adjusted values of eGFR and ACR.</p><p><strong>Results: </strong>No significant difference in multivariable adjusted ACR or eGFR was found at 18 months. The intervention group showed a non-significant decrease in adjusted eGFR (1.83 mL/min/1.73 m² lower, p = 0.15) and ACR (14%, p = 0,56). Stratified results revealed lower eGFR in patients > 60 years 3.64 mL/min/1.73 m², p = 0.03) and those with baseline ACR ≤ 300 mg/g (3.64 mL/min/1.73, p = 0.007).</p><p><strong>Conclusion: </strong>LI-ESWT did not demonstrate overall statistically significant effects on eGFR and ACR at 3, 6, 12, or 18 months. However, secondary analyses suggest possible effects in certain subgroups. Clinical studies with larger samples are needed to clarify the efficacy of LI-ESWT in specific DKD patient subgroups. Trial Registration The trial was prospectively registered July 31, 2015, at ClinicalTrials.gov with registration number NCT02515461.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key strategies for reducing recurrence in T1 bladder cancer. Evidence from a retrospective multicenter European study.","authors":"Roberto Contieri, Alexandre Guigui, Bastien Gondran-Tellier, Giuseppe Basile, Fabio Zattoni, Andrea Gallioli, Paolo Verri, Julia Aumatell, Eric Lechevallier, Cyrille Bastide, Akram Akiki, Harry Toledano, Marco Moschini, Daniele Amparore, Laura S Mertens, Benjamin Pradere, Paweł Rajwa, Jeremy Y C Teoh, Francesco Porpiglia, Alberto Breda, Francesco Montorsi, Michael Baboudjian, Alessandro Uleri","doi":"10.1007/s11255-025-04416-2","DOIUrl":"https://doi.org/10.1007/s11255-025-04416-2","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate whether adherence to specific quality criteria in the management of T1 non-muscle-invasive bladder cancer (NMIBC) undergoing second-look transurethral resection of bladder tumor (TURBT) leads to improved oncological outcomes.</p><p><strong>Materials and methods: </strong>A retrospective multicenter study included patients diagnosed between 2015 and 2021 with high or very-high-risk a NMIBC after initial TURBT, followed by second-look TURBT and Bacillus Calmette-Guérin (BCG) adjuvant therapy. Key management steps assessed included enhanced tumor visualization, complete resection, timing of second look, detrusor muscle presence in specimens, and adequate BCG therapy. The primary endpoint was bladder recurrence-free survival (RFS), analyzed using Kaplan-Meier curves and Cox regression models.</p><p><strong>Results: </strong>Among 226 patients included, the median age was 73(65-79) years, and 49 were classified in the very high-risk group (22%). Second-look TURBT was performed with a median delay of 8 (6-10) weeks. Factors significantly impacting 3-year RFS included adequate BCG exposure (HR = 0.55; 95% CI 0.32-0.93; p = 0.03) and the presence of residual tumor at second-look TURBT (HR = 2.55; 95% CI 1.48-4.39; p < 0.001). Neither the use of photodynamic diagnostics nor timing beyond 6 weeks for second-look TURBT significantly influenced outcomes (p > 0.05).</p><p><strong>Conclusions: </strong>In T1 NMIBC, adequate BCG therapy and absence of residual tumor at second-look TURBT are the primary predictors of 3-year RFS. These findings emphasize the importance of quality management in TURBT procedures and patient treatment.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspiration properties of flexible and navigable suction ureteral access sheath (FANS) and flexible ureteroscope with direct-in-scope suction (DISS): an in-vitro experimental study by EAU young academic urologists (YAU) urolithiasis and endourology working group.","authors":"Arman Tsaturyan, Angelis Peteinaris, Eugenio Ventimiglia, Hakob Sargsyan, Armen Muradyan, Tarik Emre Sener, Etienne X Keller, Vincent De Coninck, Francesco Esperto, Giannis Mykoniatis, Patrick Juliebø-Jones, Lazaros Tzelves, Alba Sierra Del Rio, Steffi Kar Kei Yuen, Vineet Gauhar, Olivier Traxer, Evangelos Liatsikos, Panagiotis Kallidonis, Bhaskar Somani, Amelia Pietropaolo","doi":"10.1007/s11255-025-04405-5","DOIUrl":"https://doi.org/10.1007/s11255-025-04405-5","url":null,"abstract":"<p><strong>Purpose: </strong>To illustratively evaluate and compare the effectiveness of aspiration of 7.5Fr and 9.2Fr single-use flexible ureteroscopes with direct in-scope-suction (DISS) with a 12/14Fr flexible and navigable suction ureteral access sheath (FANS) in an in-vitro setting.</p><p><strong>Methods: </strong>Our experimental setup included a 6.5-size sterile glove, 2 mm and 4 mm stone fragments, and a porcine ureter. Three experimental scenarios were evaluated in the upper, middle and lower calyx: 1. Suction via 12/14Fr FANS, 2. Suction via 7.5Fr DISS, 3. Suction via 9.2Fr DISS.</p><p><strong>Results: </strong>Evacuation of the 2 mm stone was reported in all trials regardless of the used instrument. Aspiration and repositioning of the 4 mm fragment was observed from the upper calyx with all instruments. In the middle calyx, stone evacuation was successful in 5 out of 5 trials with 7.5Fr DISS, and 3 out of 5 with 12/14Fr FANS or 9.2Fr DISS. Stone relocation using suction with subsequent evacuation of the 4 mm fragment from the lower calyx was achieved in none of the trials with 12/14Fr FANS and only in 1 trial with 9.2Fr DISS scope whereas it was successful in 4 trials when 7.5Fr DISS was used. Collapse of the pelvicalyceal system (PCS) was more pronounced with the 12/14Fr FANS and 9.2Fr DISS scope (3-4 s) compared to 7.5Fr DISS scope (6-7 s).</p><p><strong>Conclusion: </strong>In this study, the 7.5Fr single-use flexible ureteroscope was found to be superior in terms of stone extraction and relocation, while it seemed to have less impact on the collapse of the PCS compared to 9.2Fr DISS and 12/14Fr FANS.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary metabolomics analysis of patients with renal tubular dysfunction after PCI surgery.","authors":"Wenwen Huang, Xinxin Chen, Xiaoyan Xu, Shufang Pan","doi":"10.1007/s11255-025-04397-2","DOIUrl":"https://doi.org/10.1007/s11255-025-04397-2","url":null,"abstract":"<p><strong>Purpose: </strong>Differences in metabolic profiles were used to search for urinary metabolic markers in patients with tubular dysfunction after percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>In this study, 50 patients with renal tubule dysfunction 6 h after PCI were collected and urine samples before PCI were used as control group and 6 h after PCI were used as observation group. The urine samples were processed by high-speed centrifugation, filtered by microporous membrane, and the superclear was obtained for LC-MS detection and analysis, and their metabolic profiles and related data were obtained.</p><p><strong>Results: </strong>Compared with the control group, α1-MG, NAG and Cys-C in the urine of the observation group were significantly increased, and the difference was statistically significant (P < 0.05). After the urine samples were processed by LC-MS technology, SIMCA realized the visual visualization of the score plots of PCA, OPLS-DA and other models, and then verified by statistical methods, it was found that there were different metabolites in the urine of patients before and after PCI. The HMDB database was used to search for differential metabolites and 16 different metabolites such as L-ornithine, oleic acid amide, D-histidine, p-hydroxyphenyllactic acid, acetylmethionine, N-(2-furanyl) glycine, cholesterol laurate, cholic acid, 1-methylguanine, L-hydrochloric acid, homovanillic acid, alpha-keto-isocaproic acid, 3-β-hydroxy-D5-cholenoic acid, adenine, palmitic acid, pentadecanoic acid. Pathway Analysis in MetaboAnalyst5.0 was used to analyze the metabolic pathways of 16 different metabolites. Finally, a total of 11 metabolic pathways were matched. Finally, we believe that the biosynthetic pathway of arginine and the metabolic pathway of alanine, aspartate and glutamate are most relevant to tubular dysfunction after percutaneous coronary intervention (PCI).</p><p><strong>Conclusion: </strong>In this study, LC-MS technology was used to analyze urine samples from CIN patients and patients with coronary heart disease before and after PCI and a total of 16 different metabolites were screened out, which may serve as potential biomarkers to help diagnose renal tubular dysfunction. There are 11 metabolic pathways in the body involved in the occurrence and development of renal tubular dysfunction after angiography and the biosynthesis pathway of arginine and the metabolic pathway of alanine, aspartate and glutamate may play the most important role in the occurrence and development of renal tubular dysfunction.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of flow rate and ratio of endoscope-sheath diameter on stone removal in flexible ureteroscopic lithotripsy: in vitro and CFD analyses insights.","authors":"Bin Zhang, Shuaihong Han, Lei Zhang, Xin Wang, Xuhui Zhang, Xuezhi Liang, Dongwen Wang","doi":"10.1007/s11255-025-04392-7","DOIUrl":"https://doi.org/10.1007/s11255-025-04392-7","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a theoretical framework for stone removal in flexible ureteroscopic lithotripsy (FURL) using a soft-tip negative pressure ureteral access sheath (SNP-UAS), we examined how flow rate (FR) and ratio of endoscope-sheath diameter (RESD) affect maximum pull-back speed (max-PBS) through in vitro experiments and computational fluid dynamics (CFD) analyses. Furthermore, we sought to initially clarify the principles behind stone movement in FURL.</p><p><strong>Methods: </strong>Two sub-studies examined the effects of FR and RESD on PBS during SNP-UAS-assisted FURL while focusing on the principles of stone movement. The first sub-study involved in vitro experiments that referenced the male urinary tract, using an appropriately curved SNP-UAS with a 0.30 cm ball as a stone model. Initially, the minimum FR required for effective max-PBS in in vitro experiments was observed under a commonly used RESD (0.73) and FR between 20.00 and 50.00 ml/min. Subsequently, variations in max-PBS were analyzed across three RESD values (0.73, 0.79, and 0.87) and available FR levels (50.00, 70.00, and 90.00 ml/min). The second sub-study involved CFD analyses utilizing a simplified model, with an SNP-UAS oriented vertically and a circle of 0.30 cm diameter as stone model. Initially, circle's movement was examined at a PBS of 0.00 cm/s, RESD of 0.73, and FR from 20.00 to 100.00 ml/min, with preliminary movement principles explained. Next, circle's movement was assessed at a PBS of 5.00 cm/s, FR of 50.00 ml/min, and RESD values of 0.73, 0.79, and 0.87.</p><p><strong>Results: </strong>In the first sub-study, only the 50.00 ml/min FR group achieved the max-PBS, and max-PBS increased with higher FR and larger RESD. In the second sub-study, at FR of 50.00 ml/min and above, the circle ascended faster towards the water inlet as FR increased. During the circle's accelerated and uniform movement phase, the pressure surrounding it balanced, but vortices persisted and changed. At FR 50.00 ml/min and 5.00 cm/s PBS, higher RESD led to quicker and further circle ascent.</p><p><strong>Conclusion: </strong>In vitro experiments and CFD analyses reveal that higher RESD and FR enhance PBS during FURL using SNP-UAS, aiding individual stone removal. The stone movement is directly driven by surrounding vortices, not pressure differences.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of intravesical alkalinized lignocaine for cystoscopy: a retrospective analysis.","authors":"Kirti Singh, Manoj Kumar Das, Swarnendu Mandal, Suman Sahoo, Vivek Tarigopula, Sambit Tripathy, Kalandi Barik, Prasant Nayak","doi":"10.1007/s11255-025-04401-9","DOIUrl":"https://doi.org/10.1007/s11255-025-04401-9","url":null,"abstract":"<p><strong>Purpose: </strong>To study the effect of intravesical instillation of alkalinized lignocaine (AL) solution on pain scores and patient tolerance in patients undergoing cystoscopy. Bladder distension, trigonal irritation, and bladder neck irritation during cystoscopy under local anesthesia contribute significantly to patient discomfort.</p><p><strong>Methods: </strong>This was a retrospective case-control study performed at a single center from January 2023 to July 2023 (Institutional Ethics Committee approval: T/IM-NF/Urol/23/194). Prior to cystoscopy, patients in control group (Group A) (LG group) received only 10 ml of 2% lignocaine HCl gel (LG) per-urethrally, while intervention group (Group B) (AL group) also received 30 ml of AL solution intravesically (20 min prior). Postoperative pain scores were compared using visual analog scale (VAS). The patient tolerance, postoperative hematuria, experience with the procedure, persistent LUTS, and incidence of UTI after 1 week were also compared.</p><p><strong>Results: </strong>The study included 50 male patients in each group undergoing cystoscopy for LUTS under evaluation, unexplained hematuria and check cystoscopy for Ca bladder; the median age was comparable between the groups. The VAS scores at 0 h [2(2-3) vs. 5(4-5); p < 0.001], 1 h [1(1-2) vs. 3(3-4); p < 0.001], and 2 h [0 vs. 1(1-1); p < 0.001] were better in Group B. Patient tolerance and experience with the procedure, assessed 1 week postoperatively, were significantly better in Group B. Postoperative clinical features and incidence of LUTS at 1 week postoperatively were significantly less in Group B.</p><p><strong>Conclusion: </strong>Using intravesical AL solution significantly reduces pain and improves patient tolerance and satisfaction during cystoscopy; also, it is safe and well-tolerated.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the link between nephrolithiasis and osteoporosis: implications for clinical management and treatment advancements.","authors":"Momina Ahmed, Hafsa Zareen, Maheen Shaharyar","doi":"10.1007/s11255-025-04408-2","DOIUrl":"https://doi.org/10.1007/s11255-025-04408-2","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}