International Urology and Nephrology最新文献

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Varieties of altered TFE3 can occur in MiT-family-related renal cell carcinomas.
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-02-18 DOI: 10.1007/s11255-025-04394-5
Allison K Kennedy, Hassan D Kanaan, Kanika Arora, Harry Zhang, Jason M Hafron, Shelly L Kaufman, Mark A Micale, Ping L Zhang
{"title":"Varieties of altered TFE3 can occur in MiT-family-related renal cell carcinomas.","authors":"Allison K Kennedy, Hassan D Kanaan, Kanika Arora, Harry Zhang, Jason M Hafron, Shelly L Kaufman, Mark A Micale, Ping L Zhang","doi":"10.1007/s11255-025-04394-5","DOIUrl":"https://doi.org/10.1007/s11255-025-04394-5","url":null,"abstract":"<p><strong>Background: </strong>In TFE3 translocation renal cell carcinoma (RCC), rearrangements involving the TFE3 gene can lead to overexpression of the TFE3 transcription factor. This upregulation increases lysosomal activity and autophagy, which in turn contributes to tumor cell proliferation. Although TFE3 translocation RCC is one of the more extensively studied RCC subtypes, other genetic abnormalities, such as gene copy number alterations, may also play a role in disease development. Accordingly, this study aimed to more precisely categorize TFE3-altered RCC variants using fluorescence in situ hybridization (FISH), while also evaluating their histopathological characteristics and clinical behavior.</p><p><strong>Methods: </strong>In this retrospective study spanning the past 9 years, 16 cases of renal cell carcinoma (RCC) were examined for TFE3 gene alterations using FISH. The cohort was divided into two groups: TFE3-altered RCC cases as the positive group (n = 6) and TFE3-negative RCC cases as the negative group (n = 10). TFE3 alterations, tumor pathology, and clinical outcomes were systematically evaluated.</p><p><strong>Results: </strong>The age of patients with TFE3-altered RCC ranged from 6 to 70 years old. There were five female patients and one male patient, which is consistent with the known female predominance of this RCC subtype. The TFE3 alterations observed in this cohort included: TFE3 gene rearrangement (n = 1), TFE3 gene rearrangement with copy number gain (n = 1), copy number gain of intact TFE3 gene (n = 3), and copy number loss of TFE3 gene (n = 1). Clinical outcomes varied, with some patients experiencing poor prognoses, including the development of distant metastases.</p><p><strong>Conclusions: </strong>Our data show that TFE3 alterations in RCC span a range of genetic events, from gene rearrangements to copy number variations, as determined by FISH. These TFE3-altered RCCs in adults may be associated with unfavorable outcomes, underscoring the value of FISH in both diagnosing and refining our understanding of TFE3-altered RCC.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling interrelationships through structural equation modeling: family function, social networks, and social phobia in peritoneal dialysis patients.
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-02-17 DOI: 10.1007/s11255-025-04396-3
Zongbi Wu, Yuxin Yan, Huifang Cai, Shikun Qi, Mingming Xu, Taifen Wang, Youli Jiang
{"title":"Unveiling interrelationships through structural equation modeling: family function, social networks, and social phobia in peritoneal dialysis patients.","authors":"Zongbi Wu, Yuxin Yan, Huifang Cai, Shikun Qi, Mingming Xu, Taifen Wang, Youli Jiang","doi":"10.1007/s11255-025-04396-3","DOIUrl":"https://doi.org/10.1007/s11255-025-04396-3","url":null,"abstract":"<p><strong>Background: </strong>Peritoneal dialysis (PD) enhances quality of life for end-stage renal disease patients, however, family function, social networks, and social phobia may significantly influence patient outcomes. This study explores the interrelationships among these factors in a Chinese population of PD patients, considering the socio-cultural context of Shenzhen as an immigrant city.</p><p><strong>Methods: </strong>This cross-sectional study included 259 PD patients from Shenzhen Traditional Chinese Medicine Hospital, recruited between December 2023 and April 2024. Participants completed validated questionnaires assessing family function (Family APGAR), social networks (LSNS-6), and social phobia (SASS-CS). Data were analyzed using Spearman correlation and Structural Equation Modeling (SEM) to examine direct and indirect relationships among the variables.</p><p><strong>Results: </strong>Most participants demonstrated moderate to high family function. Social network scores positively correlated with family function (r = 0.46, P < 0.001), while family function negatively correlated with social phobia (r = -0.48, P < 0.05). SEM revealed that family function partially mediated the relationship between social networks and social phobia, accounting for 42.1% of the total effect. Good model fit indices were observed (χ<sup>2</sup>(32) = 48.23, P = 0.042; RMSEA = 0.045; CFI = 0.978; TLI = 0.970).</p><p><strong>Conclusion: </strong>This study underscores the critical role of social networks in supporting family function and reducing social phobia in PD patients. Interventions aimed at strengthening social networks and addressing social phobia could improve family dynamics and patient outcomes.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of quality of life in patients undergoing hyperthermic intravesical chemotherapy (HIVEC) using EORTC questionnaires (QLQ-C30 and QLQ-NMIBC24).
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-02-17 DOI: 10.1007/s11255-025-04418-0
Vincenzo Iossa, Antonio Olivieri, Roberto Buonopane, Antonio Di Girolamo, Felice Fiore, Gaetano Sessa, Raffaele Vitale, Ugo Maggio, Alessandro Pontel, Angelo Ferraro, Vittorio Imperatore
{"title":"Assessment of quality of life in patients undergoing hyperthermic intravesical chemotherapy (HIVEC) using EORTC questionnaires (QLQ-C30 and QLQ-NMIBC24).","authors":"Vincenzo Iossa, Antonio Olivieri, Roberto Buonopane, Antonio Di Girolamo, Felice Fiore, Gaetano Sessa, Raffaele Vitale, Ugo Maggio, Alessandro Pontel, Angelo Ferraro, Vittorio Imperatore","doi":"10.1007/s11255-025-04418-0","DOIUrl":"https://doi.org/10.1007/s11255-025-04418-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to assess changes in quality of life (QoL) experienced by patients undergoing hyperthermic intravesical chemotherapy (HIVEC), using validated EORTC QLQ-C30 and EORTC QLQ-NMIBC24 questionnaires.</p><p><strong>Methods: </strong>Between 2021 and 2024, 67 patients with high-risk non-muscle-invasive bladder cancer (NMIBC) who experienced BCG failure or intolerance were enrolled in an HIVEC regimen at our institution. Functional outcomes were evaluated through the EORTC QLQ-C30 and EORTC QLQ-NMIBC24 questionnaires administered at baseline (prior to treatment), after six weekly instillations (induction phase), after three monthly instillations (3 months), and after an additional six monthly instillations (9 months). Each response was assigned a specific score to assess QoL variations over time.</p><p><strong>Results: </strong>Of the 67 patients enrolled, 13 discontinued the therapy. After 9 months, 54 patients completed the EORTC QLQ-C30 and NMIBC24 questionnaires. The QLQ-C30 results indicate that the therapy did not significantly affect daily activities, despite reported increases in fatigue and weakness. However, negative impacts were observed in terms of pain, concentration, and engagement in recreational activities, alongside growing concerns about disease recurrence. The NMIBC24 questionnaire revealed an increase in urinary frequency, associated insomnia, and discomfort related to catheter use. Additionally, there was a decline in libido and anxiety about contaminating their partners.</p><p><strong>Conclusions: </strong>While the initial phase of HIVEC therapy significantly impacts QoL, particularly regarding pain and psychological concerns, it does not drastically affect daily activities in the long term. Nevertheless, the treatment has a negative influence on both physical and mental well-being, contributing to increased anxiety and limitations in social and recreational activities, as well as reduced sexual function.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erythema along hemodialysis vascular access.
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-02-17 DOI: 10.1007/s11255-025-04425-1
Masayuki Tanemoto, Yoshito Iida, Takahiro Kasai
{"title":"Erythema along hemodialysis vascular access.","authors":"Masayuki Tanemoto, Yoshito Iida, Takahiro Kasai","doi":"10.1007/s11255-025-04425-1","DOIUrl":"https://doi.org/10.1007/s11255-025-04425-1","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kidney stones in patients with Wilson's disease at a tertiary hospital in Northeastern Brazil.
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-02-16 DOI: 10.1007/s11255-025-04411-7
Gabriel Rotsen Fortes Aguiar, Luiz Paulino Gomes Neto, José Milton de Castro Lima, Rodrigo Vieira Costa Lima, Geraldo Bezerra da Silva Júnior, Elizabeth De Francesco Daher, Janaína Ramalho
{"title":"Kidney stones in patients with Wilson's disease at a tertiary hospital in Northeastern Brazil.","authors":"Gabriel Rotsen Fortes Aguiar, Luiz Paulino Gomes Neto, José Milton de Castro Lima, Rodrigo Vieira Costa Lima, Geraldo Bezerra da Silva Júnior, Elizabeth De Francesco Daher, Janaína Ramalho","doi":"10.1007/s11255-025-04411-7","DOIUrl":"https://doi.org/10.1007/s11255-025-04411-7","url":null,"abstract":"<p><p>Wilson's disease (WD) is an autosomal recessive disorder caused by mutations in the ATP7B gene leading to abnormal copper accumulation in tissues. Although the hepatic and neuropsychiatric effects of WD are well-documented, renal complications such as nephrolithiasis are less explored. This article examines the prevalence of nephrolithiasis and associated risk factors in a cohort of 36 WD patients. We also review reported cases and proposed mechanisms explaining copper-induced renal toxicity's role in the clinical presentation. In our cohort, nephrolithiasis was detected via abdominal ultrasound in 10% of patients. Although hypercalciuria and acid-base abnormalities associated with WD have been reported in the literature, such findings were not observed in metabolic evaluations performed late in the disease course among our WD patients with kidney stones. Recognizing the less acknowledged renal manifestations of WD highlights the importance of comprehensive evaluations and timely therapeutic interventions to prevent complications and improve outcomes in WD.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of nocturnal polyuria in patients with nocturia based on voiding frequency.
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-02-16 DOI: 10.1007/s11255-025-04402-8
Teppei Nishiwaki, Kota Kawase, Yoshinori Nishino, Kanako Matsuoka, Tatsuya Ihara, Shunta Makabe, Ryo Tanji, Yuki Harigane, Kenichiro Ishida, Masayoshi Tamaki, Hiroki Hoshino, Kazuya Yuhara, Toru Yamada, Kousei Miwa, Mina Kikuchi, Masayuki Tomioka, Tomoki Taniguchi, Makoto Kawase, Koji Iinuma, Yuki Tobisawa, Keita Nakane, Yoshiyuki Kojima, Takahiko Mitsui, Takuya Koie
{"title":"Prediction of nocturnal polyuria in patients with nocturia based on voiding frequency.","authors":"Teppei Nishiwaki, Kota Kawase, Yoshinori Nishino, Kanako Matsuoka, Tatsuya Ihara, Shunta Makabe, Ryo Tanji, Yuki Harigane, Kenichiro Ishida, Masayoshi Tamaki, Hiroki Hoshino, Kazuya Yuhara, Toru Yamada, Kousei Miwa, Mina Kikuchi, Masayuki Tomioka, Tomoki Taniguchi, Makoto Kawase, Koji Iinuma, Yuki Tobisawa, Keita Nakane, Yoshiyuki Kojima, Takahiko Mitsui, Takuya Koie","doi":"10.1007/s11255-025-04402-8","DOIUrl":"https://doi.org/10.1007/s11255-025-04402-8","url":null,"abstract":"<p><strong>Purpose: </strong>To examine daytime voiding patterns in patients with nocturnal polyuria (NP) and identify a novel predictive indicator based on voiding frequency ratios.</p><p><strong>Methods: </strong>A retrospective analysis of 875 patients with nocturia from 17 Japanese institutions (January 2018-December 2022) was conducted. Patients were divided into two groups based on the nocturnal polyuria index (NPi) > 33% (NP) or ≤ 33% (non-NP). Daytime and nighttime voiding frequencies and volumes were collected from bladder diaries. The correlation between the NPi and voiding parameters was assessed using Spearman's rank correlation. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive ability of the nighttime-to-24-h voiding frequency ratio for NP.</p><p><strong>Results: </strong>Patients with NP urinated significantly less frequently and produced more urine during the day than those without NP (p < 0.001). The ratio of nocturnal to 24-h voiding frequency showed a significant positive correlation with NPi (r = 0.38, p < 0.001) and was the strongest predictor of NP. ROC curve analysis showed that this ratio could predict NP, with an area under the curve (AUC) of 0.79. A cutoff value of 0.23 yielded 75% sensitivity and 68% specificity for predicting NP.</p><p><strong>Conclusions: </strong>This study demonstrates that patients with NP exhibit significantly reduced daytime voiding frequency and urine volume compared with those without NP. The nighttime-to-24-h voiding is useful for roughly predicting NP at the time of the initial consultation and has the potential to become more practical and accurate with further accumulation of data and research.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel risk-predicted nomogram for acute kidney injury progression in decompensated cirrhosis: a double-center study in Vietnam.
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-02-15 DOI: 10.1007/s11255-025-04398-1
Nghia N Nguyen, Bao T Nguyen, Thuy D T Nguyen, Tam T T Tran, Tan N H Mai, Huyen N T Le, Hoang N Dang, Vy B N Nguyen, Nhi Y T Ngo, Cuong T Vo
{"title":"A novel risk-predicted nomogram for acute kidney injury progression in decompensated cirrhosis: a double-center study in Vietnam.","authors":"Nghia N Nguyen, Bao T Nguyen, Thuy D T Nguyen, Tam T T Tran, Tan N H Mai, Huyen N T Le, Hoang N Dang, Vy B N Nguyen, Nhi Y T Ngo, Cuong T Vo","doi":"10.1007/s11255-025-04398-1","DOIUrl":"https://doi.org/10.1007/s11255-025-04398-1","url":null,"abstract":"<p><strong>Objectives: </strong>Acute kidney injury (AKI) is commonly encountered in patients hospitalized for decompensated cirrhosis and is associated with prolonged hospital stays, increased treatment burden, and even mortality. The present study aimed to determine the prevalence of and develop a predictive nomogram for AKI in patients with decompensated cirrhosis.</p><p><strong>Methods: </strong>This cross-sectional, double-center study involved 544 patients hospitalized with decompensated cirrhosis. Acute kidney injury was diagnosed using American Gastroenterological Association's guidelines with one more criterion: an increase in serum creatinine ≥ 0.3 mg/dL within 48 h or an increase in serum creatinine ≥ 50% compared to baseline serum creatinine or when the urine output is reduced below 0.5 mL/kg/h for > 6 h. We used the Bayesian model averaging method find the optimal model for predicting AKI. A predictive nomogram was also developed to enable risk prediction.</p><p><strong>Results: </strong>The overall AKI prevalence was 26.7% (95% Confidence interval [CI] 25.7-27.7). The optimal model for predicting AKI included diuretic therapy (odds ratio [OR]: 5.55; 95%CI 3.31-9.33), infection (OR: 2.06; 95%CI 1.31-3.22), ascites (OR: 3.20; 95%CT: 1.67-6.13), Child-Pugh group C (OR: 2.91; 95%CI 1.84-4.62), serum potassium (OR per 1 mmol/L increase: 1.62; 95%CI 1.25-2.1) and serum chloride (OR per 1 mmol/L decrease: 1.03; 95%CI 1.01-1.06). The area under the receiver operating characteristic curve was 0.8, with a 95%CI ranging from 0.75 to 0.84.</p><p><strong>Conclusions: </strong>Acute kidney injury was relatively common among patients hospitalized for decompensated cirrhosis. A novel nomogram-including diuretic therapy, infection, ascites, Child-Pugh group C, serum potassium and, serum chloride, was helpful for the selective screening of AKI in patients with decompensated cirrhosis.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment: "Comparison between the effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and their combination on mortality in maintenance dialysis patients: a systematic review and meta-analysis".
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-02-15 DOI: 10.1007/s11255-025-04419-z
Shubham Kumar, Nosaibah Razaqi, Rachana Mehta, Ranjana Sah
{"title":"Comment: \"Comparison between the effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and their combination on mortality in maintenance dialysis patients: a systematic review and meta-analysis\".","authors":"Shubham Kumar, Nosaibah Razaqi, Rachana Mehta, Ranjana Sah","doi":"10.1007/s11255-025-04419-z","DOIUrl":"https://doi.org/10.1007/s11255-025-04419-z","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary experience with minimally invasive transvaginal single-port laparoscopic vesicovaginal fistula repair: report of 10 cases.
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-02-13 DOI: 10.1007/s11255-025-04410-8
Qi Zeng, Xin Chang Zou, Bin Wang, Hai Chao Chao, Jian Biao Huang
{"title":"Preliminary experience with minimally invasive transvaginal single-port laparoscopic vesicovaginal fistula repair: report of 10 cases.","authors":"Qi Zeng, Xin Chang Zou, Bin Wang, Hai Chao Chao, Jian Biao Huang","doi":"10.1007/s11255-025-04410-8","DOIUrl":"https://doi.org/10.1007/s11255-025-04410-8","url":null,"abstract":"<p><strong>Background and purpose: </strong>As a common complication following genitourinary trauma, the methods and approaches for repairing vesicovaginal fistulas (VVF) remain controversial. Minimally invasive techniques, such as laparoscopy, are gaining widespread attention. This study summarizes our surgical experiences and postoperative management regarding transvaginal single-port laparoscopic repair of vesicovaginal fistulas.</p><p><strong>Patients and methods: </strong>We retrospectively analyzed the clinical data of 10 transvaginal single-port laparoscopic vesicovaginal fistula repairs performed in the Department of Urology at the Second Affiliated Hospital of Nanchang University from September 2022 to August 2023. All patients had complex vesicovaginal fistulas that had been treated poorly by multiple surgeries. This analysis included the causes of the fistulas, perioperative care, and efficacy. We recorded the operation time, intraoperative blood loss, and length of hospital stay, and we analyzed and summarized the surgical methods and treatment outcomes. Patients were followed up for 12 months post-surgery to assess urinary leakage and changes in their quality of life.</p><p><strong>Results: </strong>Among the 10 patients, the average age was 58 ± 4.10 years. All surgeries were successfully completed. The average operation time was 96 ± 15 min, with an average postoperative hospital stay of 5.70 ± 0.64 days. The urethral catheter was removed after 2 weeks of follow-up, and no patients experienced complications such as bleeding, urinary leakage, or infection. One month post-operation, both the cystomelan infusion test and cystography indicated no presence of a fistula or residual fistula tract. Follow-up cystoscopy conducted 3 months after the surgery showed that the fistula had completely healed, demonstrating remarkable surgical outcomes. One year after the surgery, the patients were asymptomatic and showed no signs of recurrence.</p><p><strong>Conclusion: </strong>Transvaginal single-port laparoscopic vesicovaginal fistula repair is safe and effective in treating complex vesicovaginal fistula, while retaining bladder function to the greatest extent, and is worthy of clinical promotion and application.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of antibiotic resistance and risk factors of extended-spectrum beta-lactamases-producing Escherichia coli in hospitalized children with community-acquired urinary tract infections.
IF 1.8 4区 医学
International Urology and Nephrology Pub Date : 2025-02-13 DOI: 10.1007/s11255-025-04417-1
Yuan Lin, Qin Peng, Wangqiang Li, Biquan Chen
{"title":"Analysis of antibiotic resistance and risk factors of extended-spectrum beta-lactamases-producing Escherichia coli in hospitalized children with community-acquired urinary tract infections.","authors":"Yuan Lin, Qin Peng, Wangqiang Li, Biquan Chen","doi":"10.1007/s11255-025-04417-1","DOIUrl":"https://doi.org/10.1007/s11255-025-04417-1","url":null,"abstract":"<p><strong>Objective: </strong>The incidence of extended-spectrum beta-lactamases (ESBLs)-producing Escherichia coli (E. coli) infections is rising. This study investigates the antibiotic resistance profiles and risk factors associated with ESBL-producing E. coli in urinary tract infections (UTIs) among hospitalized children, providing a basis for rational clinical management.</p><p><strong>Methods: </strong>We analyzed the clinical data of 140 children diagnosed with UTIs caused by E. coli at Anhui Provincial Children's Hospital from July 2021 and June 2024 in this retrospective study.</p><p><strong>Results: </strong>Among the 140 E. coli strains isolated, the male-to-female ratio was 1.75:1, with a median age of 7 months. Seventy-five strains (53.6%) were identified as ESBL producers. Non-ESBL-producing strains exhibited the highest resistance to ampicillin (60%) and lower resistance rates to cephalosporins and monobactams. Resistance rates for ampicillin-sulbactam, piperacillin-tazobactam, and cefoperazone-sulbactam were 29.2%, 6.2%, and 6.2%, respectively. No resistance to nitrofurantoin was observed, and only two strains were resistant to carbapenems. ESBL-producing strains demonstrated significantly higher resistance rates to most clinically relevant antimicrobials compared to non-producing strains. Among cephalosporins, resistance rates exceeded 90% for cefazolin, cefuroxime, and ceftriaxone, followed by cefepime (65.3%) and ceftazidime (29.3%). Notably, resistance to ampicillin-sulbactam was 50.7%, with greater sensitivity observed for cefoperazone-sulbactam and piperacillin-tazobactam. Resistance to cefotetan and nitrofurantoin remained low, and no carbapenem-resistant ESBL-producing strains were identified. Multifactorial logistic regression analysis indicated that abnormal urinary tract structure and a history of antibiotic treatment within the past 3 months were independent risk factors for UTIs caused by ESBL-producing E. coli (OR = 2.323, 95% CI = 1.052-5.129, P = 0.037 and OR = 3.378, 95% CI = 1.116-10.224, P = 0.031, respectively).</p><p><strong>Conclusions: </strong>ESBL-producing E. coli infections in pediatric UTIs are very common in our hospital, with high resistance rates to many used antibiotics. Awareness of the risk factors-namely, abnormal urinary tract structure and recent antibiotic treatment-is essential for effective management. Empirical treatment should involve a rational selection of antimicrobials based on local bacterial resistance patterns.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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