International Urology and Nephrology最新文献

{"title":"Nomograms with arterial spin labeling for diagnosing early-stage chronic kidney disease.","authors":"Yongkang Ma, Ran Guo, Jiazhen Wu, Huihui Xu, Chengxiu Zhang, Lingwei Zhou, Xinlei Ye, Qian Wang, Bernd Kuehn, Caixia Fu, Mengxiao Liu, Qingqing Wen, Tingting Mao, Guang Yang, Shuohui Yang","doi":"10.1007/s11255-025-04821-7","DOIUrl":"https://doi.org/10.1007/s11255-025-04821-7","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic kidney disease (CKD) is a global health issue, and early detection and intervention improve prognosis. We sought to construct diagnostic models and nomograms for early staging of CKD using renal blood flow (RBF) from magnetic resonance imaging (MRI) arterial spin labeling, combined with clinical and laboratory data.</p><p><strong>Methods: </strong>A total of 205 participants (training cohort: 124, internal test cohort: 32, and external test cohort: 49), including 48 healthy volunteers (HVs) and 157 CKD stage (S) 1-2 patients undergoing RBF MRI examination, were enrolled. Cortical and medullary RBF were measured, and clinical and laboratory data were recorded. Diagnostic models and nomograms were constructed for differentiating early-stage CKD (S1-2 and S1) patients from HVs using clinical, laboratory characteristics, and RBF values. Area under the curve (AUC), decision curve analysis (DCA), and calibration curve were employed to evaluate the performance, clinical utility, and predictive accuracy of the models.</p><p><strong>Results: </strong>AUCs for differentiating CKD S1-2 and S1 patients from HVs were 0.841 [95% confidence interval (CI) 0.704-0.978] and 0.900 (95% CI 0.739-1.000) in the internal test cohort, and 0.933 (95% CI 0.853-1.000) and 0.895 (95% CI 0.762-1.000) in the external test cohort. The calibration curve and DCA confirmed that nomograms of the combined models demonstrated good concordance between observed and predicted probabilities and better clinical benefit.</p><p><strong>Conclusion: </strong>The combined model and nomogram built using MRI RBF, clinical, and laboratory data could distinguish patients in the early stages of CKD from healthy subjects.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Sudoku puzzle solving on memory and anxiety of hemodialysis patients: a randomized controlled clinical trial.","authors":"Elham Heydari, Kobra Rahzani, Davood Hekmatpou, Firouzeh Moeinzadeh","doi":"10.1007/s11255-025-04847-x","DOIUrl":"https://doi.org/10.1007/s11255-025-04847-x","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive and psychological disorders are among the most important outcomes of the end stage of renal disease. Treatments have neither definitely prevented the disorders' progression nor cured them. This study aims at evaluating the effect of solving a Sudoku puzzle on memory and anxiety in hemodialysis (HD) patients.</p><p><strong>Materials and methods: </strong>This randomized controlled clinical trial study was conducted on 64 HD patients. The samples were randomly assigned either to the control group (n = 32) or Sudoku (intervention) group (n = 32). The study lasted for four weeks. The anxiety and memory of the participants were measured by the Spielberger State Trait Anxiety Inventory (STAI-S) and Wechsler Memory Scale (WMS) at the beginning and end of the study. The intervention group solved the Sudoku puzzle within 20 min for four weeks, three times per week (12 times), 15 min after the HD onset, the control group received no intervention. To evaluate the effect of the Sudoku puzzle on momentary anxiety, the state anxiety of all samples was measured and recorded in the first session of the study, 40 min after the onset of the first HD session. The data were analyzed with SPSS software version 25.</p><p><strong>Results: </strong>The mean and standard deviation of the anxiety score were 82.71 ± 5.1 and 70.93 ± 18.0 in the Sudoku group (p = 0.001) and 82.43 ± 5.77 and 82.06 ± 4.55 in the control group at the beginning and the end of the study, respectively (p = 0.778). Moreover, the mean and standard deviation of the state anxiety score in the first session were 41.37 ± 3.29 and 38.5 ± 2.9 in the intervention group (p = 0.001) and 39.5 ± 2.9 and 42.15 ± 2.73 in the control group (p = 0.001) before the HD onset and 40 min after the HD onset, respectively. There was no statistically significant difference in memory scores in the Sudoku group before and after the intervention. However, the covariance test showed that at the end of the study, there was a statistically significant difference between memory scores in the control and intervention groups(p = 0.048). The results showed that there is a statistically significant difference in the post tests between the two groups in terms of anxiety, state anxiety and memory (p ≤ 0.05).</p><p><strong>Conclusion: </strong>Sudoku solving seems to play an effective role in reducing anxiety and state anxiety in HD patients, but it has little effect in improving memory. Therefore, it is recommended to use it as an adjunctive treatment to control anxiety and improve memory in hemodialysis patients.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shield or risk immunosuppressant choice and Pneumocystis pneumonia after kidney transplant.","authors":"Dua Jabbar, Noor Un Nisa Irshad, Baby Nisha, Chandni Bai, Fnu Ghansham, Prem Chand","doi":"10.1007/s11255-025-04835-1","DOIUrl":"https://doi.org/10.1007/s11255-025-04835-1","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond biochemical associations: methodological gaps in a study of roxadustat, copper, and thyroid function.","authors":"Siffat Ullah, Ayesha Javed, Azan Khan, Hussain Ramzan","doi":"10.1007/s11255-025-04840-4","DOIUrl":"10.1007/s11255-025-04840-4","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical translation of renal nanotherapeutics: addressing key unmet challenges.","authors":"Touqeer Rehman, Maiza Naseer, Syed Sameer Haider, Kamran Mateen, Gulalai Tahir","doi":"10.1007/s11255-025-04841-3","DOIUrl":"https://doi.org/10.1007/s11255-025-04841-3","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation and functional recovery in older CKD inpatients.","authors":"Aqsa Memon, Shubham Makkar, Ajay Malviya, Fnu Karishma, Syed Khooshal Fareeduddin, Ali Karim","doi":"10.1007/s11255-025-04825-3","DOIUrl":"https://doi.org/10.1007/s11255-025-04825-3","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Analysis of acute glomerulonephritis disease burden and incidence trends in China, 1990-2021\".","authors":"Attiqa Khan, Waqar Muhammad, Mohammad Adil Khan, Mansoor Ijaz Bhatti, Fnu Karishma, Ali Karim","doi":"10.1007/s11255-025-04836-0","DOIUrl":"https://doi.org/10.1007/s11255-025-04836-0","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding perspectives on preemptive high-KDPI kidney transplantation in older adults.","authors":"Fnu Attiqa, Waqar Muhammad, Mohammad Adil Khan, Mansoor Ijaz Bhatti, Fnu Karishma, Ali Karim","doi":"10.1007/s11255-025-04832-4","DOIUrl":"https://doi.org/10.1007/s11255-025-04832-4","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magneto Ho:YAG laser versus Thulium Fiber Laser for laser lithotripsy during flexible ureteroscopy with a flexible and navigable ureteral access sheath.","authors":"Luis Rico, Leandro Blas, Juliana Álvarez Jaramillo, Guillermina Filgueira, Juan Soldano, Pablo Contreras","doi":"10.1007/s11255-025-04819-1","DOIUrl":"https://doi.org/10.1007/s11255-025-04819-1","url":null,"abstract":"<p><strong>Introduction: </strong>The continuous advances in laser technology for endoscopic lithotripsy have revolutionized the endourology. In order to achieve increasingly finer dust, new pulse modulations with lower peak power have emerged, such as the new magneto Ho:YAG laser (M-Ho:YAG). The aim of this study is to compare the intraoperative outcomes between thulium fiber laser (TFL) and M-Ho:YAG.</p><p><strong>Materials and methods: </strong>A retrospective study was conducted of patients undergoing flexible ureteroscopy (RIRS) for non-complex kidney stones in the Hospital Aleman of Buenos Aires, Argentina. Groups were divided according to the laser technology used: Group 1 = M-Ho:YAG laser and Group 2 = TFL. We used a 10/12 Fr or 11/13 Fr flexible and navigable ureteral access sheath (FANS) in all patients. Stone-free rate (SFR) was defined as the absence of any fragments on a non-contrast computed tomography scan at 4 weeks after the procedure. In addition, according to the new definitions of laser ablative performance, the ablative efficiency was estimated as the stone volume per unit of energy (mm³/Joules), the lithotripsy efficacy as the stone volume per unit of operative time (mm3/min) and the laser energy consumption as the energy consumed per unit of stone volume (Joules/mm³).</p><p><strong>Results: </strong>127 patients were included (Group 1 = 51 and Group 2 = 76). There were no significant differences in demographic variables between both groups (sex, age, body mass index, and procedure laterality). Furthermore, there was no significant difference in stone volume or stone density between groups. Ablative efficacy (25.7 vs. 24.7, p = 0.49), efficiency (0.18 vs. 0.16, p = 0.76), and laser energy consumption (11.5 vs. 11.1, p = 0.68) were significantly comparable between both groups, as was the SFR (98% vs. 94.7%, p = 0.35).</p><p><strong>Conclusion: </strong>In this first clinical comparison between both laser technologies, no significant differences were found in the most important intra- and postoperative results. Larger and randomized studies are required to confirm these outcomes.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysphagia, chronic kidney disease and the risks of thickened fluids.","authors":"Shaun T O'Keeffe","doi":"10.1007/s11255-025-04845-z","DOIUrl":"https://doi.org/10.1007/s11255-025-04845-z","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}