International Urology and Nephrology最新文献

{"title":"Analysis of gut microbiota variations in patients with Henoch-Schönlein purpura: a comprehensive systematic review.","authors":"Khaled Saad, Muhammad Abd-Ellatif, Nehal E Abdel-Hakem, Abdelrahman Ali, Osama Ahmed Khalil, Tasbih Emad, Omar Abo-Gazia, Asmaa Eldamaty, Yusof M Omar, Mohammad Alzu'bi, Mohammad Bazzazeh, Ahmed Afifi, Amira H El-Ashry, Sherin A Taha, Hoda Atef Abdelsattar Ibrahim, Thamer Alruwaili, Amira Elhoufey, Hamad Ghaleb Dailah, Anas Elgenidy","doi":"10.1007/s11255-025-04406-4","DOIUrl":"10.1007/s11255-025-04406-4","url":null,"abstract":"<p><strong>Objective: </strong>The primary purpose of our study was to perform a comprehensive systematic review, aiming to bring out the association between gut microbiota, Henoch-Schönlein Purpura (HSP) and Henoch-Schönlein nephritis (HSPN) patients.</p><p><strong>Methods: </strong>A systematic review was performed using five electronic databases, including Medline (through PubMed), Scopus, Embase, Cochrane, and Web of Science, from inspection up to March 21, 2024, to detect the studies that assessed the gut microbiota variation in Henoch-Schönlein Purpura (HSP) and Henoch-Schönlein nephritis (HSPN) patients.</p><p><strong>Results: </strong>Microbial diversity, richness, and composition in HSP patients are decreased compared to the healthy control group. In addition, HSP patients display a different microbiota structure and show a significant difference in taxonomic abundance between HSP and health control, which differs from one level to another. At the phylum level, Bacteroidetes, Fusobacteria, and Blastocladiomycota were more abundant; at the class level, Bacteroidetes were more abundant; at the order level, Bacteroidetes were more abundant in the HSP group-stage and site of HSP involvement effect on microbiota. Gastrointestinal tract involvement is characterized by increased abundance of Streptococcus and Fusobacteria and a decrease in Faecalibacterium. Kidney involvement is characterized by increased abundance of Streptococcus spp, which can be used as an indicator of disease severity. Escherichia-Shigella can be used as a diagnostic for the recurrence of HSP because its abundance is higher than primary HSP.</p><p><strong>Conclusion: </strong>Gut microbiota can be utilized to assess the severity, recurrence, and site of HSP infection by analyzing the diversity, richness, and abundance of specific microorganisms associated with the condition.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2195-2208"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnic diversity and urolithiasis: a single-center experience.","authors":"Kamran Hassan Bhatti, Rawa Bapir, Faaz Salah Gomha, Berun A Abdalla, Nadeem Sohail, Fattah H Fattah, Bnar Sardar Saida, Ahmed H A Shaat, Bryar Othman Muhammed, Khalid Mohammed Abdelrahman, Karukh K Mohammed, Shaima Q Abdalla, Hero Kh Mala, Dyari Q Hamad, Hiwa O Abdullah, Fahmi H Kakamad","doi":"10.1007/s11255-025-04387-4","DOIUrl":"10.1007/s11255-025-04387-4","url":null,"abstract":"<p><p>Despite the diversity in the prevalence and risk factors of urolithiasis across different geographic regions, limited information exists among various ethnic groups of the same population. This study investigates the prevalence of kidney stones (KSs) among different ethnicities in a single center in Qatar and the risk factors associated with KS formation. This retrospective cross-sectional study was on Qatari residents who visited Al-Khor Hospital between January 1, 2014 and December 31, 2019. All adult permanent residents who presented with KSs or visited the hospital for general check-ups and for whom the required data were available were included. There was a highly significant difference in KS prevalence among ethnicities (p-value < 0.001). The Egyptians had the highest prevalence of KSs (78.5%), followed by Qataris (65.0%), Palestinians (63.5%), Bangladeshis (59.4%), Syrians (55.9%), Jordanians (53.8%), and Yemenis (53.5%). However, no significant difference was found when comparing the different races regarding urolithiasis (p-value = 0.19). Individuals with hypertension and diabetes mellitus had a significantly higher prevalence of KSs (p-value = 0.001). Among patients with prior renal surgery and positive family history, 59.9% and 70.5% had KSs, compared to 49.1% and 48.3% without previous surgery and negative family history (p-values = 0.002 and < 0.001, respectively). Smoking, poor dietary intake, alcohol consumption, and severe exposure to sunlight were significantly associated with KSs (p-value < 0.001). Urolithiasis among the Qatari population is multifactorial and shows variation based on ethnicity, with natives being the second most frequently affected group.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2107-2117"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-intensity extracorporeal shockwave therapy in patients with diabetic kidney disease: a matched cohort study.","authors":"Sofus Valentin Vestersager, Sune Moeller Skov-Jeppesen, Knud Bonnet Yderstraede, Claus Bistrup, Boye L Jensen, Lars Lund","doi":"10.1007/s11255-025-04379-4","DOIUrl":"10.1007/s11255-025-04379-4","url":null,"abstract":"<p><strong>Purpose: </strong>Low-intensity extracorporeal shockwave therapy (LI-ESWT) is a potential novel treatment against diabetic kidney disease (DKD). The present study investigates the longer term effects of LI-ESWT on kidney function in patients with DKD.</p><p><strong>Methods: </strong>This matched cohort study included 28 patients with DKD, who received six sessions of LI-ESWT. Patients were matched 1:5 with patients from the Funen Diabetes Database. Multivariable adjusted eGFR and ACR were analyzed using multilevel mixed-effects linear regression. The primary outcomes were ACR and eGFR measured at 3, 6, 12, and 18 month follow-up. Secondary analyses with patients stratified for sex, age, baseline eGFR, and baseline ACR were made for the multivariable adjusted values of eGFR and ACR.</p><p><strong>Results: </strong>No significant difference in multivariable adjusted ACR or eGFR was found at 18 months. The intervention group showed a non-significant decrease in adjusted eGFR (1.83 mL/min/1.73 m² lower, p = 0.15) and ACR (14%, p = 0,56). Stratified results revealed lower eGFR in patients > 60 years 3.64 mL/min/1.73 m², p = 0.03) and those with baseline ACR ≤ 300 mg/g (3.64 mL/min/1.73, p = 0.007).</p><p><strong>Conclusion: </strong>LI-ESWT did not demonstrate overall statistically significant effects on eGFR and ACR at 3, 6, 12, or 18 months. However, secondary analyses suggest possible effects in certain subgroups. Clinical studies with larger samples are needed to clarify the efficacy of LI-ESWT in specific DKD patient subgroups. Trial Registration The trial was prospectively registered July 31, 2015, at ClinicalTrials.gov with registration number NCT02515461.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2245-2253"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence: vancomycin-associated AKI in cirrhosis: a modifiable risk factor absent from current prediction models.","authors":"Maryna Rodrigues Gonçalves, Guilherme Triches, Tammy Shiroma, Eric Akio Hiraga, Allan Bevilaqua Queiros Neto, Carolina Yamada, Tamires Maier, Rosa Marcusso, João Paulo Telles","doi":"10.1007/s11255-025-04632-w","DOIUrl":"https://doi.org/10.1007/s11255-025-04632-w","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning and transcriptomic analysis identify tubular injury biomarkers in patients with chronic kidney disease.","authors":"Feifei Sun, Jiahui Cai, Qiaoyun Pan, Yunbo Sun, Shasha Zhao, Weiping Liu, Qiang Tan, Yanling Yan","doi":"10.1007/s11255-025-04636-6","DOIUrl":"https://doi.org/10.1007/s11255-025-04636-6","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic Kidney Disease (CKD) is emerging as a major public health problem, with a lack of precise diagnostic biomarkers in clinical settings. The primary objective is to discover biomarkers for early clinical detection of CKD and to gain a deeper understanding of its underlying pathophysiological processes.</p><p><strong>Methods: </strong>Samples from renal tubules of CKD patients and healthy controls were subjected to differential expression analysis. Weighted Gene Co-expression Network Analysis (WGCNA) was utilized to detect genes associated with renal tubular damage in CKD. Subsequently, Support Vector Machine Recursive Feature Elimination (SVM-RFE) and Least Absolute Shrinkage and Selection Operator (LASSO) algorithms were employed to identify and validate potential biomarker candidates.</p><p><strong>Results: </strong>Four key renal biomarkers, namely DUSP1, GADD45A, TSC22D3, and ZFAND5, were successfully identified. Receiver Operating Characteristic (ROC) curve analysis and nomogram construction demonstrated their remarkable diagnostic capabilities. These biomarkers were also found to affect the degree of immune cell infiltration in CKD and exhibited a notable correlation with Glomerular Filtration Rate (GFR) and serum creatinine (SCr) levels.</p><p><strong>Conclusion: </strong>These four identified biomarkers for renal tubular injury play important roles in immune function and inflammatory responses in CKD, potentially providing a theoretical foundation for dissecting molecular mechanisms and developing therapeutic strategies in CKD.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of low-intensity pulsed ultrasound (LIPUS) in the treatment of erectile dysfunction: a systematic review.","authors":"Mehmet Yilmaz, Mustafa Karaaslan, Mehmet Emin Şirin, Halil Çağrı Aybal, Muhammed Emin Polat, Selim Soyturk, Tuncay Toprak, Senol Tonyali, Selcuk Guven","doi":"10.1007/s11255-025-04639-3","DOIUrl":"https://doi.org/10.1007/s11255-025-04639-3","url":null,"abstract":"<p><strong>Purpose: </strong>Low-intensity pulsed ultrasound (LIPUS) is a form of mid-frequency ultrasound (0.7-3 MHz) delivered in pulse wave mode (100 and 1000 Hz). LIPUS delivers high-frequency sound waves with low-intensity mechanical energy that can be transmitted to cells and thus tissues, thereby producing biological effects. The regenerative activity of LIPUS in tissues, including the cavernous nerve, has been demonstrated in numerous studies. In this systematic review, we aimed to evaluate the efficacy of LIPUS on erectile dysfunction (ED).</p><p><strong>Methods: </strong>A systematic search was conducted using PubMed-MEDLINE and Web of Science databases with the following search terms as of March 2, 2025: ''low-intensity pulsed ultrasound AND erectile dysfunction'',''LIPUS AND erectile dysfunction'', ''low-intensity pulsed ultrasound AND erectile function'', ''low-intensity pulsed ultrasound AND penile erection '' by combining PICO (population, intervention, comparison, outcome) terms.</p><p><strong>Results: </strong>A total of six studies involving 615 patients undergoing LIPUS were identified. Three of these were randomized controlled trials (RCT), and three were non-RCT. Two studies have analysed ED associated with Peyronie's disease and chronic prostatitis/chronic pelvic pain syndrome. One study compared LIPUS with LIPUS + tadalafil and one study compared LIPUS with LIPUS + biofeedback electric stimulation in patients with ED. One study compared LIPUS with a sham-treated control group, and another study compared the efficacy of LIPUS treatment 2-3 times per week. The studies reported a significant increase in IIEF scores after LIPUS treatment compared to baseline levels.</p><p><strong>Conclusion: </strong>In spite of limited reports in the literature, LIPUS may be a promising non-invasive treatment for the management of ED.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proenkephalin A 119-159 as a biomarker for predicting sepsis-associated acute kidney injury.","authors":"Bo-Kun Ji, Zhen-Nan Xie, Xue-Hua Pu, Ning Gao, Ji-Lu Ye, Yin-Feng Han","doi":"10.1007/s11255-025-04631-x","DOIUrl":"https://doi.org/10.1007/s11255-025-04631-x","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to assess the predictive value of serum proenkephalin A 119-159 (penKid) levels for acute kidney injury (AKI) associated with sepsis (SA-AKI).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted from September 2021 to September 2022. Clinical characteristics and laboratory parameters were compared between the AKI and non-AKI groups. Risk factors for the development of SA-AKI were identified using Cox regression analysis. In addition, receiver operating characteristic (ROC) curve analysis was conducted to assess the predictive ability of each identified risk factor for AKI among patients with sepsis.</p><p><strong>Results: </strong>A total of 161 patients diagnosed with sepsis or septic shock were included, among whom 66 developed AKI, representing an incidence rate of 41.0%. Baseline lactic acid (LA) levels were significantly higher in the AKI group compared to the non-AKI group. Similarly, baseline penKid concentrations were significantly elevated in the AKI group compared to the non-AKI group. Serum LA and penKid levels were identified as independent risk factors for AKI in patients with sepsis or septic shock. ROC curve analysis demonstrated that the baseline penKid concentration significantly predicted AKI in this population (p < 0.001), with an area under the curve of 0.867, sensitivity of 0.788, and specificity of 0.832 when the penKid threshold was set at 2.41 μg/L.</p><p><strong>Conclusion: </strong>Serum penKid levels may serve as a reliable biomarker for the early detection of AKI in patients presenting with sepsis or septic shock.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study on the effects of intravesical BCG on urinary microbiota in bladder cancer patients.","authors":"Joseph Kai Man Li, Lin Wang, Ryan Tsz Hei Tse, Chi Ho Leung, Kang Liu, Hongda Zhao, Carol Ka Lo Cheng, Christine Yim Ping WonG, Stephen Kwok Wing Tsui, Gianluca Giannarini, Alex Qinyang Liu, Peter Ka Fung Chiu, Chi Fai Ng, Jeremy Yuen Chun Teoh","doi":"10.1007/s11255-025-04607-x","DOIUrl":"https://doi.org/10.1007/s11255-025-04607-x","url":null,"abstract":"<p><strong>Background: </strong>Urinary bladder cancer is among the most common malignancy worldwide. Despite surgical interventions and regular surveillance, recurrence and progression to advanced disease are observed in patients. Intravesical administration of Bacillus Calmette-Guérin (BCG) could reduce bladder cancer recurrence and progression in patients with intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC). Nonetheless, not all patients respond well to BCG treatment. We aim to evaluate whether bacteria profiles were altered after BCG administration.</p><p><strong>Methods: </strong>In this cross-sectional study, we investigate the differences in urinary microbiome between non-cancerous controls, bladder cancer patients undergoing surveillance cystoscopy, and patients with BCG administration (post-BCG). The V4 regions of the 16S rRNA gene were sequenced, and alpha-diversity and beta-diversity were analyzed. Taxonomic differences between groups and metabolic function analysis of bacteria groups were investigated.</p><p><strong>Results: </strong>Comparing to the other two groups, the proportion of Pseudomonas, Lactococcus, and Bacillus were increased in the post-BCG group. Superpathways of L-phenylalanine biosynthesis, L-tyrosine biosynthesis, ubiquinol-7, 8, 9, 10 biosynthesis, lipopolysaccharide biosynthesis, glucose degradation oxidative, and 4-hydroxyphenylacetate degradation were significantly enhanced in the post-BCG group.</p><p><strong>Conclusion: </strong>Results demonstrated that urinary bacteria profiles were distinguished between controls and post-BCG patients. Certain bacteria genus was shown to enhance in post-BCG patients, revealing that the change in the urinary microbiome might be associated with BCG treatment.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of calcitriol therapy for reduction of proteinuria in children with chronic kidney disease: an open-label randomized controlled trial.","authors":"Jitendra Meena, Ranjeet W Thergaonkar, Aditi Sinha, R Lakshmy, Arvind Bagga, Pankaj Hari","doi":"10.1007/s11255-025-04623-x","DOIUrl":"https://doi.org/10.1007/s11255-025-04623-x","url":null,"abstract":"<p><strong>Purpose: </strong>Reducing proteinuria in children with chronic kidney disease (CKD) has been shown to slow the progression of kidney damage. Hence, we examined the efficacy of a combination of calcitriol and enalapril as compared to enalapril alone in reducing proteinuria in children with CKD.</p><p><strong>Methods: </strong>Children aged 3 to 18 years with CKD and proteinuria > 250 mg/m²/day were randomized to receive enalapril (0.6 mg/kg/daily) with or without calcitriol (0.25 µg twice weekly) for 6 months. Children with estimated GFR (eGFR) < 30 ml/min/1.73 m², serum calcium > 10.5 mg/dl, and phosphate > 5.5 mg/dl were excluded. A primary outcome was a mean difference in the change in proteinuria at 6 months compared to baseline. Secondary outcomes included changes in PTH and eGFR.</p><p><strong>Results: </strong>Of 212 screened children with CKD and proteinuria, 72 (56 boys, mean age 11.2 ± 3.4 yr) were randomized. Baseline characteristics were similar in both groups. Proteinuria decreased from the baseline to the end of therapy by median 1.05 (IQR: 0.04 to 1.87) g/day with the combination therapy as compared to median 0.49 (IQR: 0.03 to 1.33) g/day in enalapril group (P = 0.54). The percentage reduction in proteinuria was 60.4% with the combination therapy and 50.1% with enalapril therapy (P = 0.48). Three patients developed hyperphosphatemia in enalapril therapy; hypercalcemia and hyperkalemia were not observed.</p><p><strong>Conclusion: </strong>In children with CKD, the combination of calcitriol and enalapril did not result in significant reduction in proteinuria than enalapril alone. Combination therapy was tolerated well. Further studies with a larger sample size and a longer duration of follow-up studies are needed. Trial registration https://ctri.nic.in CTRI/2011/10/002086. Registered in October 21, 2011.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating mitophagy-associated lncRNAs to predict prognosis and therapeutic response in clear cell renal cell carcinoma.","authors":"Guofan Hu, Shuangze Zhong, Hansheng Lin, Jingwei He","doi":"10.1007/s11255-025-04626-8","DOIUrl":"https://doi.org/10.1007/s11255-025-04626-8","url":null,"abstract":"<p><strong>Purpose: </strong>Clear cell renal cell carcinoma (ccRCC) is a heterogeneous malignancy with limited prognostic biomarkers. This study aimed to explore the prognostic value of mitophagy-related long non-coding RNAs (MRlncRNAs) and construct a risk model to assist survival prediction and clinical decision-making.</p><p><strong>Methods: </strong>Transcriptomic, clinical, and somatic mutation data of ccRCC patients were obtained from The Cancer Genome Atlas (TCGA). MRlncRNAs were identified through co-expression with mitophagy-related genes. A prognostic risk model was constructed using Cox and LASSO regression analyses and validated in independent cohorts. Functional analyses explored associations with the immune microenvironment, tumor mutation burden (TMB), and drug sensitivity.</p><p><strong>Results: </strong>Five MRlncRNAs (AC002070.1, AC092953.2, AC103706.1, LINC01943, and LINC02027) were identified as independent prognostic biomarkers. The risk model effectively stratified patients into high- and low-risk groups with significant differences in overall survival (OS) and progression-free survival. Low-risk patients exhibited enhanced anti-tumor immune activity and greater sensitivity to drugs such as bortezomib, while high-risk patients showed immune suppression, higher TMB, and increased responsiveness to agents targeting EGFR and TGF-β pathways.</p><p><strong>Conclusion: </strong>This study developed and validated a robust MRlncRNA-based prognostic model for ccRCC that integrates mitophagy-related molecular features with immune and therapeutic profiles. This model provides novel insights for prognostic evaluation and offers a promising tool for guiding individualized treatment strategies.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}