International Urology and Nephrology最新文献

{"title":"Harnessing AI for real-time monitoring and precision medicine: enhancing cardiovascular risk prediction in CKD management through panimmune-inflammation value.","authors":"Anshal Ahmad, Rayyan Nabi, Dure Shehwar","doi":"10.1007/s11255-025-04482-6","DOIUrl":"10.1007/s11255-025-04482-6","url":null,"abstract":"","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2723-2724"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring kidney microanatomy during ischemia-reperfusion using ANFIS optimized CNN.","authors":"Niranjana Devi Balakrishnan, Suresh Kumar Perumal","doi":"10.1007/s11255-025-04449-7","DOIUrl":"10.1007/s11255-025-04449-7","url":null,"abstract":"<p><p>Kidney disease is a dangerous disease that affects human health and causes various defects. Renal microbiological changes can be monitored using optical coherence tomography (OCT) images to identify the nature of the disease based on behavior during ischemia-reperfusion. Image analysis becomes the more sophisticated part of extracting information from feature dependencies from objects to identify the disease. Most methodologies use feature correlation dependencies in non-relation feature analysis-based disease identification with low precision and recall level. So, classification accuracy needs to be higher performance. To resolve this problem, we proposed the adaptive neuro-fuzzy inference system-based Resnet50 optimal convolutional neural network (ANFIS-CNN) method implemented using deep learning (DL) to monitor kidney disease. Initially, we analyze using OCT images collected from a standard repository. Furthermore, bidirectional filters can be used for preprocessing to reduce image noise. Gaussian filtering can be applied to identify the dependence of kidney structure. Afterward, the color density saturation can be analyzed through edge-based segmentation using the histogram equalization method, and the optimally extracted objects can be identified through edge-based segmentation. These spectral value-based relative feature detection thresholds are combined with texture point-based recursive spectral multiscale feature selection (RSMFS) to produce different entity contrasts. Then, spectral values are optimized with ANFIS-Resnet50 optimal CNN to classify the accuracy by selecting images. Moreover, the proposed method results in high classification accuracy up to 96.1 %, recall rate 95.18 % and precision up to 96.09 % well attained, enhancing their overall performance. The system develops high-performance image recognition for kidney disease monitoring.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2637-2648"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New equation for estimating glomerular filtration rate in Vietnamese kidney transplant recipients.","authors":"Bao An Huynh, Nguyen Huy Hoang Ho, Thi Tram Anh Bui, Khac Chuan Hoang, Thai Thanh Tam Tran","doi":"10.1007/s11255-025-04458-6","DOIUrl":"10.1007/s11255-025-04458-6","url":null,"abstract":"<p><strong>Purpose: </strong>Accurate assessment of kidney function is essential for post-kidney transplant management. This study aims to develop a new equation tailored to Vietnamese kidney transplant recipients and validate its performance against established equations.</p><p><strong>Methods: </strong>A total of 299 kidney transplant recipients underwent glomerular filtration rate (GFR) measurement using technetium-99m-diethylenetriaminepentaacetate renal dynamic scintigraphy, along with demographic, clinical, and laboratory assessments. Participants were divided into a development cohort (n = 150) to generate a new GFR-estimating equation and a validation cohort (n = 149) for internal validation against six equations.</p><p><strong>Results: </strong>The new equation, <math><mrow><mi>G</mi> <mi>F</mi> <mi>R</mi> <mo>=</mo> <mn>100.430</mn> <mo>×</mo> <mn>1</mn> <mo>.</mo> <msup><mn>080</mn> <mrow><mi>sex</mi></mrow> </msup> <mo>×</mo> <mi>a</mi> <mi>g</mi> <msup><mi>e</mi> <mrow><mo>-</mo> <mn>0.097</mn></mrow> </msup> <mo>×</mo> <mi>S</mi> <mi>c</mi> <msup><mi>r</mi> <mrow><mo>-</mo> <mn>0.524</mn></mrow> </msup> <mo>×</mo> <mi>S</mi> <mi>c</mi> <mi>y</mi> <msup><mi>s</mi> <mrow><mo>-</mo> <mn>0.435</mn></mrow> </msup> </mrow> </math> (sex: 0 = female; 1 = male), showed the smallest median bias (-0.11 [-1.40; 1.11]), highest P₃₀ accuracy (94.0% [88.6; 96.6]), highest precision (interquartile range = 9.82 [7.63; 12.37]), and strongest correlation with measured GFR (r = 0.824 [0.752; 0.880]) among tested equations in the validation cohort. Among creatinine-based equations, the Modification of Diet in Renal Disease equation was the most accurate.</p><p><strong>Conclusion: </strong>The new equation outperformed established equations and is recommended for Vietnamese kidney transplant recipients. The Modification of Diet in Renal Disease equation may serve as an alternative in centers lacking access to serum cystatin C. Further studies with larger cohorts, external validation, and comparisons with gold-standard GFR measurement methods are needed to confirm these results.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2657-2667"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An updated systematic review and meta-analysis on the efficacy of supine versus prone position for pediatric PCNL.","authors":"Honggang Fang, Fuming Zhu, Kongkong Cui, Xing Liu, Shengde Wu, Yi Hua, Tao Lin, Dawei He, Guanghui Wei, Deying Zhang","doi":"10.1007/s11255-025-04428-y","DOIUrl":"10.1007/s11255-025-04428-y","url":null,"abstract":"<p><strong>Background: </strong>The incidence of pediatric kidney stones is increasing with recurrence rates ranging from 35 to 50%. Supine percutaneous nephrolithotomy (PCNL) presents a viable alternative to the conventional prone position, offering specific benefits but also posing certain risks.</p><p><strong>Objective: </strong>To update a previously published systematic review and meta-analysis comparing the efficacy of PCNL in the supine versus prone positions in children.</p><p><strong>Methods: </strong>A systematic search of Web of Science, Cochrane Library, PubMed, and Embase was conducted to identify eligible studies. Two authors independently screened the literature and extracted data. The meta-analysis was performed using StataMP 17. The study was prospectively registered in PROSPERO (ID: CRD42024545145). The sensitivity and subgroup analyses explored sources of heterogeneity, and publication bias was assessed with a funnel plot. The study adhered to PRISMA guidelines and the Cochrane Handbook.</p><p><strong>Results: </strong>This study included a total of nine studies, comprising five randomized controlled trials and four case-control studies, with 614 patients in total. Compared with the prone position group, the supine position group demonstrated significant advantages in terms of operative time (WMD = - 15.43, 95% CI: - 22.18 to - 8.69, P = 0.0001), hospital stay (WMD = - 0.77, 95% CI: - 1.12 to - 0.42, P = 0.0001), overall complication rate (OR = 0.46, 95% CI: 0.42-0.99, P = 0.046), and hemoglobin decrease (WMD = - 0.22, 95% CI: - 0.40 to - 0.05, P = 0.013). However, no significant differences were observed between the two groups in stone clearance rate, high-grade complication rate, or radiation exposure time. Subgroup analysis revealed that in studies published after 2024, cases of small stones (< 2 cm), and older children (> 9 years), the supine position group had fewer low-grade complications. Additionally, in the supine PCNL group with ultrasound or endoscopy-assisted puncture, radiation exposure time was significantly reduced.</p><p><strong>Conclusion: </strong>This study shows that supine position PCNL in children is superior to the prone position in terms of operative time, hospital stay, complication rate, and hemoglobin decrease, with no significant difference in stone clearance, high-grade complications, or radiation exposure. The subgroup analysis found that supine position resulted in fewer low-grade complications in studies published after 2024, small stones, and older children. It also significantly reduced radiation exposure with ultrasound or endoscopy-assisted puncture, suggesting that supine position is a safer and more effective option.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2345-2358"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity in patients receiving peritoneal dialysis: a systematic evaluation and meta-analysis.","authors":"Xueli Man, Peiyao Ren, Ting Lin, Xiaobo Shen, Juan Jin, Qiang He","doi":"10.1007/s11255-025-04426-0","DOIUrl":"10.1007/s11255-025-04426-0","url":null,"abstract":"<p><strong>Background: </strong>Exercise has been proven to be beneficial for both the general population and individuals with chronic diseases. However, the specific effects of physical activity on patients undergoing peritoneal dialysis (PD) remain unclear.</p><p><strong>Aim: </strong>This systematic review and meta-analysis aims to evaluate the effects of physical exercise on quality of life, physical function, pain, energy, sleep, and malnutrition-inflammation-atherosclerosis (MIA) syndrome in PD patients.</p><p><strong>Methods: </strong>We conducted a systematic search of PubMed, EMBASE, Web of science and the Cochrane Library for randomized controlled trials (RCTs) that compared routine care with physical activity interventions in patients with chronic kidney disease (CKD) undergoing PD. The search covered studies from database inception to December 2023. Outcomes were reported as mean differences (MD) with standard deviations (SD) and 95% confidence intervals (CI). All statistical analyses were performed using RevMan version 5.3.</p><p><strong>Results: </strong>We included nine RCTs involving 398 patients, with 199 (50%) randomized to the physical activity group. Follow-up ranged from 12 weeks to 6 months. Compared to routine care, the exercise group showed significant improvements in BKD (MD 9.98; 95% CI 2.14-17.82; p = 0.01), EKD (MD 7.15; 95% CI - 0.13-14.43; p = 0.05), social support (MD 9.51; 95% CI 0.27-18.75; p = 0.04), social interaction (MD 6.91; 95% CI 0.82-13.00; p = 0.03), and physical pain (MD 14.35; 95% CI 3.60-25.10; p = 0.009). Qualitative analysis revealed a significant decrease in homeostatic model assessment of insulin resistance (HOMA-IR), a significant increase in C-reactive protein (CRP), and improvements in sitting and standing tests (CS-30, FTTST, SS5) in the exercise group (p < 0.05).</p><p><strong>Conclusions: </strong>This study represents the first meta-analysis comparing usual care with exercise interventions in PD patients. The findings indicate that exercise is a viable therapeutic option. Future research should prioritize the development of tailored exercise programs to optimize PD management.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2531-2545"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspiration properties of flexible and navigable suction ureteral access sheath (FANS) and flexible ureteroscope with direct-in-scope suction (DISS): an in-vitro experimental study by EAU young academic urologists (YAU) urolithiasis and endourology working group.","authors":"Arman Tsaturyan, Angelis Peteinaris, Eugenio Ventimiglia, Hakob Sargsyan, Armen Muradyan, Tarik Emre Sener, Etienne X Keller, Vincent De Coninck, Francesco Esperto, Giannis Mykoniatis, Patrick Juliebø-Jones, Lazaros Tzelves, Alba Sierra Del Rio, Steffi Kar Kei Yuen, Vineet Gauhar, Olivier Traxer, Evangelos Liatsikos, Panagiotis Kallidonis, Bhaskar Somani, Amelia Pietropaolo","doi":"10.1007/s11255-025-04405-5","DOIUrl":"10.1007/s11255-025-04405-5","url":null,"abstract":"<p><strong>Purpose: </strong>To illustratively evaluate and compare the effectiveness of aspiration of 7.5Fr and 9.2Fr single-use flexible ureteroscopes with direct in-scope-suction (DISS) with a 12/14Fr flexible and navigable suction ureteral access sheath (FANS) in an in-vitro setting.</p><p><strong>Methods: </strong>Our experimental setup included a 6.5-size sterile glove, 2 mm and 4 mm stone fragments, and a porcine ureter. Three experimental scenarios were evaluated in the upper, middle and lower calyx: 1. Suction via 12/14Fr FANS, 2. Suction via 7.5Fr DISS, 3. Suction via 9.2Fr DISS.</p><p><strong>Results: </strong>Evacuation of the 2 mm stone was reported in all trials regardless of the used instrument. Aspiration and repositioning of the 4 mm fragment was observed from the upper calyx with all instruments. In the middle calyx, stone evacuation was successful in 5 out of 5 trials with 7.5Fr DISS, and 3 out of 5 with 12/14Fr FANS or 9.2Fr DISS. Stone relocation using suction with subsequent evacuation of the 4 mm fragment from the lower calyx was achieved in none of the trials with 12/14Fr FANS and only in 1 trial with 9.2Fr DISS scope whereas it was successful in 4 trials when 7.5Fr DISS was used. Collapse of the pelvicalyceal system (PCS) was more pronounced with the 12/14Fr FANS and 9.2Fr DISS scope (3-4 s) compared to 7.5Fr DISS scope (6-7 s).</p><p><strong>Conclusion: </strong>In this study, the 7.5Fr single-use flexible ureteroscope was found to be superior in terms of stone extraction and relocation, while it seemed to have less impact on the collapse of the PCS compared to 9.2Fr DISS and 12/14Fr FANS.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2371-2377"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated lipoprotein-associated phospholipase A2 as a biomarker for cognitive impairment in chronic kidney disease.","authors":"Sujuan Feng, Yanfeng Lin, Rong Wang, Xingxing Fang, Jiaqi Shi, Xiameng Gu, Yang Yu","doi":"10.1007/s11255-025-04469-3","DOIUrl":"10.1007/s11255-025-04469-3","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the relationship between serum lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and cognitive impairment (CI) in patients with chronic kidney disease (CKD).</p><p><strong>Methods: </strong>A total of 125 patients with CKD treated in the Department of Nephrology, The Second Affiliated Hospital of Nantong University from July 2022 to May 2023 were selected and divided into observation group (44 patients with CI) and control group (81 patients with normal cognitive function). Multivariate logistic regression analysis was performed to analyze the risk factors of CI, and Spearman rank correlation analysis was used to analyze the correlation between serum Lp-PLA2 and Montreal Cognitive Assessment Scale (MoCA) score. The truncation value of Lp-PLA2 in CKD patients with CI was analyzed by receiver operating characteristic curve (ROC).</p><p><strong>Results: </strong>Serum Lp-PLA2 levels were significantly elevated in the observation group compared to the control group (P < 0.05). The area under the ROC curve for Lp-PLA2 was 0.849, with a cutoff value of 232 ng/mL for identifying CI in patients with CKD. Lp-PLA2 levels were independently associated with CI in patients with CKD (odds ratio [OR] = 0.988, 95% confidence interval [CI]: 0.982-0.993, P < 0.001).</p><p><strong>Conclusion: </strong>Elevated serum Lp-PLA2 levels serve as an independent risk factor for CI in patients with CKD.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2705-2709"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends on the associations between chronic kidney disease and mitochondria: insights from the bibliometric analysis.","authors":"Xinfang Tang, Anna Zhang, Xiaojuan Feng, Wenjuan Wang, Fanghong Chen, Yijie Tao, Chuyan Wu, Feng Jiang","doi":"10.1007/s11255-025-04437-x","DOIUrl":"10.1007/s11255-025-04437-x","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a global health burden characterized by a progressive and irreversible loss of kidney function. Mitochondrial dysfunction has emerged as a pivotal factor in CKD pathogenesis, contributing to renal cell injury, inflammation, and fibrosis through mechanisms such as oxidative stress and impaired bioenergetics. This study aimed to provide a comprehensive bibliometric analysis of global research trends on the associations between CKD and mitochondria over the past two decades.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted using the Web of Science Core Collection database, focusing on publications from 2004 to 2024. Data were analyzed using Citespace and VOSviewer to visualize publication trends, key contributors, keyword co-occurrences, and collaboration networks.</p><p><strong>Results: </strong>A total of 2,870 publications were identified, with a significant increase in annual output observed after 2010. The United States, China, and Japan were the leading contributors, fostering strong international collaborations. Institutional analysis highlighted the prominent roles of the US Department of Veterans Affairs and the University of California System. Key authors, such as Jose Pedraza-Chaverri and HM Kang, and influential studies addressing mitochondrial quality control and metabolic reprogramming were identified. Keyword analysis revealed major research themes, including oxidative stress, ischemia-reperfusion injury, and fatty acid oxidation, with recent trends emphasizing mitochondrial dynamics and autophagy.</p><p><strong>Conclusions: </strong>This analysis underscored the growing recognition of mitochondrial dysfunction in CKD pathogenesis and highlighted the interdisciplinary nature of this field. The findings revealed key research trends, influential contributors, and emerging topics, providing a foundation for future studies and the development of targeted mitochondrial therapies. These insights hold promise for advancing the understanding and treatment of CKD through precision medicine approaches. Specifically, therapeutic strategies aimed at enhancing mitochondrial biogenesis, promoting mitophagy, and restoring metabolic balance may offer novel avenues for delaying CKD progression and mitigating renal dysfunction. Integrating these mitochondrial-targeted interventions into current clinical practice could improve patient outcomes and guide the development of more effective treatment protocols.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2579-2594"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of nocturnal polyuria in patients with nocturia based on voiding frequency.","authors":"Teppei Nishiwaki, Kota Kawase, Yoshinori Nishino, Kanako Matsuoka, Tatsuya Ihara, Shunta Makabe, Ryo Tanji, Yuki Harigane, Kenichiro Ishida, Masayoshi Tamaki, Hiroki Hoshino, Kazuya Yuhara, Toru Yamada, Kousei Miwa, Mina Kikuchi, Masayuki Tomioka, Tomoki Taniguchi, Makoto Kawase, Koji Iinuma, Yuki Tobisawa, Keita Nakane, Yoshiyuki Kojima, Takahiko Mitsui, Takuya Koie","doi":"10.1007/s11255-025-04402-8","DOIUrl":"10.1007/s11255-025-04402-8","url":null,"abstract":"<p><strong>Purpose: </strong>To examine daytime voiding patterns in patients with nocturnal polyuria (NP) and identify a novel predictive indicator based on voiding frequency ratios.</p><p><strong>Methods: </strong>A retrospective analysis of 875 patients with nocturia from 17 Japanese institutions (January 2018-December 2022) was conducted. Patients were divided into two groups based on the nocturnal polyuria index (NPi) > 33% (NP) or ≤ 33% (non-NP). Daytime and nighttime voiding frequencies and volumes were collected from bladder diaries. The correlation between the NPi and voiding parameters was assessed using Spearman's rank correlation. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive ability of the nighttime-to-24-h voiding frequency ratio for NP.</p><p><strong>Results: </strong>Patients with NP urinated significantly less frequently and produced more urine during the day than those without NP (p < 0.001). The ratio of nocturnal to 24-h voiding frequency showed a significant positive correlation with NPi (r = 0.38, p < 0.001) and was the strongest predictor of NP. ROC curve analysis showed that this ratio could predict NP, with an area under the curve (AUC) of 0.79. A cutoff value of 0.23 yielded 75% sensitivity and 68% specificity for predicting NP.</p><p><strong>Conclusions: </strong>This study demonstrates that patients with NP exhibit significantly reduced daytime voiding frequency and urine volume compared with those without NP. The nighttime-to-24-h voiding is useful for roughly predicting NP at the time of the initial consultation and has the potential to become more practical and accurate with further accumulation of data and research.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2401-2408"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of 2D shear wave elastography in assessing chronic kidney disease and its correlation with point shear wave elastography and eGFR.","authors":"Sandhya, Lukshay Bansal, Akhilandeswari Prasad, Shibani Mehra","doi":"10.1007/s11255-025-04473-7","DOIUrl":"10.1007/s11255-025-04473-7","url":null,"abstract":"<p><p>The study was conducted with the aim of calculating renal stiffness through shear wave sonoelastography (SWE) in chronic kidney disease (CKD) and in normal kidneys, to find out a cut off value to differentiate between the two. This cross-sectional study included 80 participants (40 CKD patients and 40 subjects with normal renal function) with eGFR calculated using serum creatinine taken as a biochemical parameter. All participants underwent 2D and point SWE. Values obtained as young's modulus statistical analysis was done. CKD patients had higher mean 2D elasticity of 7.92 kPa (SD ± 1.94) and mean point elasticity of 7.93 kPa (SD ± 3.83) compared to the control group. At a cutoff point of > 5.2, Elast Q provides the reliable balance between sensitivity (95%) and specificity (97.5%) for predicting CKD. To conclude, Young's modulus values derived by 2D and point SWE found to be greater in diseased kidneys than healthy kidneys. 2D SWE (Elast Q) outperforms point SWE (Elast PQ) in predicting CKD due to its higher area under the curve, better sensitivity, specificity making it more reliable diagnostic tool for CKD.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":" ","pages":"2697-2704"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}