Previous maximal transurethral resection of bladder tumor lead to unfavorable perioperative outcomes following radical cystectomy.

IF 1.8 4区医学 Q3 UROLOGY & NEPHROLOGY

International Urology and Nephrology Pub Date : 2025-06-01 Epub Date: 2025-01-09 DOI:10.1007/s11255-025-04368-7

Wentao Ma, Yuan Shui, Guilin Wang, Xiaohua Zhang, Ze Zhang, Zhilong Dong, Junqiang Tian, Yunxin Zhang, Hui Ding, Li Yang, Zhiping Wang

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引用次数: 0

Abstract

Purpose: To evaluate the impact of maximal transurethral resection of bladder tumor (TURBT) on perioperative outcomes following radical cystectomy (RC).

Methods: This study included 310 patients who underwent RC for the diagnosis of bladder urothelial carcinoma. Of these, 146 patients had a history of maximal TURBT (TURBT group) and 164 did not (non-TURBT group). Patients in the TURBT group were categorized into four groups according to the time interval between the last TURBT and RC: ≤ 1 month, 1-3 months, 3-6 months, and > 6 months. Additionally, the TURBT group was stratified into a single TURBT group and multiple TURBT group. Perioperative outcomes were compared between the groups.

Results: The median duration of pelvic drainage tube retention was longer in the TURBT group (11 vs. 9 days, p = 0.037). The incidence of Clavien-Dindo ≥ 3 complications (15.3% vs. 7.3%, p = 0.031) and ICU admission rate(10.4% vs. 4.5%, p = 0.048) were higher in the TURBT group. Statistically significant differences were observed in the incidence of Clavien-Dindo ≥ 3 complications (p = 0.007), reoperation rates (p = 0.041), incidence of sepsis (p = 0.022), and urinary complications (p = 0.024) across the four groups stratified by the time interval between TURBT and RC, with the 1-3 to months group demonstrating the highest incidence. There was no significant difference in perioperative outcomes between patients who underwent a single TURBT and those who underwent multiple TURBT.

Conclusion: Patients with a history of maximal TURBT, especially those who underwent RC within 1-3 months after maximal TURBT, have an increased risk of unfavorable perioperative outcomes following RC.

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既往经尿道膀胱肿瘤最大切除术导致根治性膀胱切除术后围手术期预后不良。

目的：探讨经尿道膀胱肿瘤最大切除术（turt）对膀胱根治术（RC）围手术期预后的影响。方法：本研究纳入310例行膀胱尿路上皮癌诊断的患者。其中，146例患者有最大TURBT史（TURBT组），164例患者无最大TURBT史（非TURBT组）。TURBT组患者根据最后一次TURBT与RC的时间间隔分为≤1个月、1-3个月、3-6个月、bbb6个月四组。并将TURBT组分为单TURBT组和多TURBT组。比较两组围手术期疗效。结果：TURBT组盆腔引流管中位留置时间更长（11天vs. 9天，p = 0.037）。TURBT组Clavien-Dindo≥3并发症发生率（15.3% vs. 7.3%, p = 0.031）和ICU入院率（10.4% vs. 4.5%, p = 0.048）较高。按TURBT与RC时间间隔分层，4组患者Clavien-Dindo≥3并发症发生率（p = 0.007）、再手术率（p = 0.041）、脓毒症发生率（p = 0.022）、泌尿系统并发症发生率（p = 0.024）差异均有统计学意义，以1-3 ~ 1个月组发生率最高。单次TURBT患者与多次TURBT患者围手术期预后无显著差异。结论：有最大turt病史的患者，特别是在最大turt后1-3个月内接受了RC的患者，在RC后出现不良围手术期结果的风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Urology and Nephrology 医学-泌尿学与肾脏学

CiteScore

3.40

自引率

5.00%

发文量

329

审稿时长

1.7 months

期刊介绍： International Urology and Nephrology publishes original papers on a broad range of topics in urology, nephrology and andrology. The journal integrates papers originating from clinical practice.