International Journal of Toxicology最新文献_第2页

Editor's note. 编者注

IF 1.2 4区医学

International Journal of Toxicology Pub Date : 2024-10-03 DOI: 10.1177/10915818241286420

Mary Beth Genter

引用次数: 0

Safety Assessment of Alkanoyl Lactyl Lactate Salts as Used in Cosmetics. 化妆品中使用的烷酰乳酸盐的安全性评估。

IF 1.2 4区医学

International Journal of Toxicology Pub Date : 2024-10-01 Epub Date: 2024-07-23 DOI: 10.1177/10915818241259694

Wilbur Johnson, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth

引用次数: 0

Safety Assessment of Polyol Phosphates as Used in Cosmetics. 化妆品中使用的多元醇磷酸盐的安全评估。

IF 1.2 4区医学

International Journal of Toxicology Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1177/10915818241259699

Wilbur Johnson, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth

引用次数: 0

Sodium Dehydroacetate and Dehydroacetic Acid. 脱氢乙酸钠和脱氢乙酸。

IF 1.2 4区医学

International Journal of Toxicology Pub Date : 2024-10-01 Epub Date: 2024-06-24 DOI: 10.1177/10915818241260276

Priya Cherian, Wilma F Bergfeld, Donald V Belsito, David E Cohen, Curtis D Klaassen, Allan E Rettie, David Ross, Thomas J Slaga, Paul W Snyder, Susan Tilton, Monice Fiume, Bart Heldreth

引用次数: 0

Safety Assessment of Methylxanthines as Used in Cosmetics. 对化妆品中使用的甲基黄嘌呤进行安全评估。

IF 1.2 4区医学

International Journal of Toxicology Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1177/10915818241260282

Priya A Cherian, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth

引用次数: 0

Safety Assessment of Vinylpyrrolidone Polymers as Used in Cosmetics. 化妆品中使用的乙烯基吡咯烷酮聚合物的安全性评估。

IF 1.2 4区医学

International Journal of Toxicology Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1177/10915818241267203

Wilbur Johnson, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice Fiume, Bart Heldreth

引用次数: 0

In Utero Exposure to Di-n-butyl Phthalate Causes Modulation in Neurotransmitter System of Wistar Rats: A Multigenerational Assessment. 子宫内暴露于邻苯二甲酸二正丁酯对 Wistar 大鼠神经递质系统的影响：多代评估。

IF 2.2 4区医学

International Journal of Toxicology Pub Date : 2024-09-12 DOI: 10.1177/10915818241278670

M J Radha,Mahaboob P Basha

{"title":"In Utero Exposure to Di-n-butyl Phthalate Causes Modulation in Neurotransmitter System of Wistar Rats: A Multigenerational Assessment.","authors":"M J Radha,Mahaboob P Basha","doi":"10.1177/10915818241278670","DOIUrl":"https://doi.org/10.1177/10915818241278670","url":null,"abstract":"Neuroendocrine regulation is disrupted by di-n-butyl phthalate (DBP) when exposure occurs during the critical periods of fetal development, which can lead to neurological disorders. To evaluate the toxic potential of DBP, it is necessary to conduct teratological studies, which could determine impacts on the development of the fetus. The present study was designed to understand the sequelae of neuroendocrine regulation in one-month-old pups when rats were exposed to DBP (F1-F3) in utero and during lactation. The rats received DBP (500 mg/kg BW/day) dissolved in olive oil through oral gavage from gestation day 6 to postnatal day 30, while the control group received the olive oil (vehicle) during the same timeline. Following the exposure, thyroid profile and estradiol, which were measured at GD-19, exhibited a significant decrease (P < 0.05) in dams (F0-F2). The exposure resulted in developmental outcomes, including underdeveloped fetuses, and a notable number of resorptions in experimental rats. The one-month-old pups were assessed for serum thyroid profile and testosterone and neurotransmitters in discrete brain regions, cerebral cortex, cerebellum, and hippocampus for up to three generations. The levels of dopamine and cortisol showed a significant increase (P < 0.05), but serotonin levels decreased when examined in distinct brain regions of the experimental group as compared to the control. DBP, which is considered an endocrine disruptor, had the most impact on the third generation in this study, leading to a significant decrease in testosterone levels. In summary, in utero exposure to DBP impaired the neuroendocrine system and had an antiandrogenic effect in the three successive generations.","PeriodicalId":14432,"journal":{"name":"International Journal of Toxicology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142205681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight of Evidence: Is an Animal Study Warranted? Assessments for Carcinogenicity, Drug Abuse Liability, and Pediatric Safety. 证据的重要性：是否需要进行动物实验？致癌性、药物滥用责任和儿童安全性评估。

IF 1.2 4区医学

International Journal of Toxicology Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI: 10.1177/10915818241259794

Thulasi Ramani, Ronald L Wange, T Scott Manetz, Paul J Kruzich, Susan B Laffan, David R Compton

引用次数: 0

13-Week Repeated Oral Toxicity and Toxicokinetic Studies of Rabeprazole Sodium and Sodium Bicarbonate Combination in Dogs. 对狗进行为期 13 周的雷贝拉唑钠和碳酸氢钠复方制剂重复口服毒性和毒物动力学研究

IF 1.2 4区医学

International Journal of Toxicology Pub Date : 2024-09-01 Epub Date: 2024-06-19 DOI: 10.1177/10915818241261631

Jae Seok Roh, Kyu-Yeol Nam, Won Tae Jung, Young-Min Kim, Eui-Kyung Hwang, Tae-Won Jeon

{"title":"13-Week Repeated Oral Toxicity and Toxicokinetic Studies of Rabeprazole Sodium and Sodium Bicarbonate Combination in Dogs.","authors":"Jae Seok Roh, Kyu-Yeol Nam, Won Tae Jung, Young-Min Kim, Eui-Kyung Hwang, Tae-Won Jeon","doi":"10.1177/10915818241261631","DOIUrl":"10.1177/10915818241261631","url":null,"abstract":"The subchronic toxicity and toxicokinetics of a combination of rabeprazole sodium and sodium bicarbonate were investigated in dogs by daily oral administration for 13 consecutive weeks with a 4-week recovery period. The dose groups consisted of control (vehicles), (5 + 200), (10 + 400), and (20 + 800) mg/kg of rabeprazole sodium + sodium bicarbonate, 20 mg/kg of rabeprazole sodium only, and 800 mg/kg of sodium bicarbonate only. Esophageal ulceration accompanied by inflammation was observed in only one animal in the male (20 + 800) mg/kg rabeprazole sodium + sodium bicarbonate group. However, the severity of the ulceration was moderate, and the site of occurrence was focally extensive; thus, it was assumed to be a treatment-related effect of rabeprazole sodium + sodium bicarbonate. In the toxicokinetics component of this study, systemic exposure to rabeprazole sodium (AUClast and Cmax at Day 91) was greater in males than females, suggesting sex differences. AUClast and Cmax at Day 91 were increased compared to those on Day 1 in a dose-dependent manner. A delayed Tmax and no drug accumulation were observed after repeated dosage. In conclusion, we suggest under the conditions of this study that the no-observed-adverse-effect level (NOAEL) of the combination of rabeprazole sodium + sodium bicarbonate in male and female dogs is (10 + 400) and (20 + 800) mg/kg, respectively.","PeriodicalId":14432,"journal":{"name":"International Journal of Toxicology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety Assessment of a Novel Intravenous Diclofenac Sodium Formulation Following 28-Day Repeated Administration in Wistar Rats. 新型静脉注射双氯芬酸钠制剂在 Wistar 大鼠体内 28 天重复给药后的安全性评估

IF 1.2 4区医学

International Journal of Toxicology Pub Date : 2024-09-01 Epub Date: 2024-06-20 DOI: 10.1177/10915818241261922

Laxit K Bhatt, Chitrang R Shah, Jitendra H Patel, Viral I Rajwadi, Pankaj Dwivedi, Rajesh J Patel, Ramchandra K Ranvir, Harilal Patel, Rajesh Sundar, Mukul R Jain

{"title":"Safety Assessment of a Novel Intravenous Diclofenac Sodium Formulation Following 28-Day Repeated Administration in Wistar Rats.","authors":"Laxit K Bhatt, Chitrang R Shah, Jitendra H Patel, Viral I Rajwadi, Pankaj Dwivedi, Rajesh J Patel, Ramchandra K Ranvir, Harilal Patel, Rajesh Sundar, Mukul R Jain","doi":"10.1177/10915818241261922","DOIUrl":"10.1177/10915818241261922","url":null,"abstract":"These toxicity studies aimed to assess the safety and tolerability of a novel intravenous diclofenac sodium (37.5 mg/mL) formulation containing povidone K12 (80 mg/mL) as the key excipient in Wistar rats. This formulation was tested at doses of 3, 7, and 15 mg/kg/day and was administered daily for 28 days by intravenous route. Toxicokinetic estimation revealed a dose-proportional increase in plasma exposure to diclofenac. The formulation was well tolerated in males; however, mortality was observed in females (2/15) at the highest dose (15 mg/kg/day). Adverse gastrointestinal events related to NSAIDS and a few other treatment-related effects on clinical and anatomic pathology were noted at the 15 mg/kg/day dose, which normalized at the end of the 2-week recovery period. In addition, the excipient povidone K12 was present in a higher amount than the approved Inactive Ingredient Database (IID) limit in the proposed novel formulation. It was qualified through a separate 28-day repeated dose toxicity study by intravenous route in Wistar rats. Povidone K12 was found to be well tolerated and safe up to a dose of 165 mg/kg/day. No treatment-related adverse effects were observed in this study. In conclusion, repeated administration of a novel intravenous formulation containing diclofenac sodium was found to be safe up to the dose of 7 mg/kg/day in female rats and 15 mg/kg/day in male rats.","PeriodicalId":14432,"journal":{"name":"International Journal of Toxicology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0