International Journal of Trichology最新文献

{"title":"Therapeutic Potential of Adipose-Derived Stem Cells and Their Secretome in Reversible Alopecias: A Systematic Review.","authors":"Alexis Ortega-Cuartiella","doi":"10.4103/ijt.ijt_3_21","DOIUrl":"10.4103/ijt.ijt_3_21","url":null,"abstract":"<p><p>Androgenic alopecia (AGA) and alopecia areata (AA) are two highly prevalent conditions, affecting both men and women of a wide range of ages, which strongly impact their quality of life and self-esteem. Both pathologies are deemed to be reversible, although conventional therapies have shown limited scope and efficacy. New therapeutic approaches, focusing on the degenerative changes that take place in the hair follicle, are needed to achieve better outcomes. For instance, adipose-derived stem cells (ADSC), abundant and easy to obtain, hold great potential in follicular regeneration. ADSCs can be isolated as stromal vascular fraction (SVF) by the enzymatic digestion of the lipoaspirate or as nanofat by the mechanical breakdown of adipocytes. In addition, commercial preparations of the conditioned medium of the ADSCs secretome (ADSC-conditionate medium [CM]) have entered the market as an appealing alternative because of their comparatively lower cost and accessibility. A search was conducted, crossing relevant terms, on PubMed Central and Google Scholar. Criteria for inclusion were studies in the past 10 years on humans with AGA or AA, where either SVF, nanofat, or ADSC-CM was tested as the main treatment. Eleven publications qualified: two studied nanofat, three, ADSC-CM, and six, SVF, either individually or in combination with other therapies. Only one randomized controlled trial (RCT) was found and classified as evidence 2b according to the Sackett scale. The rest were case-control studies or case series with small samples and no control, graded as evidence 3b and 4. A meta-analysis could not be conducted due to the heterogenicity of the study designs. Given the evidence obtained, Level D NICE recommendation was established. However, we consider that the positive findings are sufficiently consistent to support the elaboration of further RCTs that share criteria and methods.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 5","pages":"173-182"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichoscopy in Trichotillomania - Monitoring Treatment Response.","authors":"S Srisukhirthi, Sheela Kuruvila, Parthasarathy Ramamurthy","doi":"10.4103/ijt.ijt_76_22","DOIUrl":"10.4103/ijt.ijt_76_22","url":null,"abstract":"<p><p>Trichotillomania is nonscarring alopecia with recurrent pulling out of one's hair and repeated attempts to reduce hair pulling. Clinical improvement in the urge to pull out hairs in trichotillomania is often not quantifiable and based on unreliable history. Here, we present a case of trichotillomania with follow-up features on trichoscopy during treatment. By this, we propose trichoscopy as an objective tool to visualize clinical improvement in the urge to pull out hairs and assess treatment efficacy.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 5","pages":"218-220"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinical, Dermoscopic, and Histopathological Study of Follicular Psoriasis.","authors":"Maqbool Saep, Manjunath Mala Shenoy, Anuradha C K Rao, Malcolm Pinto, Spandana Prakash Hegde, Amina Asfiya M Iqbal","doi":"10.4103/ijt.ijt_168_20","DOIUrl":"10.4103/ijt.ijt_168_20","url":null,"abstract":"<p><strong>Introduction: </strong>Follicular psoriasis is one of the underdiagnosed clinical types of psoriasis. Literature is grossly limited to anecdotal case reports and series. Clinical and investigational aspects are not studied in depth.</p><p><strong>Materials and methods: </strong>A study was conducted to determine the frequency of follicular psoriasis, which includes cases with an exclusive or substantial number of follicular lesions. We analyzed the clinical, dermoscopic, and histopathological features of follicular psoriasis in a descriptive study.</p><p><strong>Results: </strong>A total of 117 patients with psoriasis were screened. An exclusive or substantial number of follicular lesions were found in 22 patients. Four patients had exclusively follicular lesions and others were psoriasis vulgaris with follicular psoriasis. Dermoscopy revealed perifollicular scaling and white homogeneous area with normal terminal hair in all cases. Vascular features were visible in 14 cases and all had dotted vessels, with four having additional globules. Twenty patients revealed one or more features suggestive of follicular psoriasis on histopathology.</p><p><strong>Conclusion: </strong>Follicular lesions can appear exclusively or can coexist with plaque type of lesions in psoriasis. They may indicate early psoriasis lesions. Dermoscopy is a useful and rapid tool to confirm the diagnosis of follicular psoriasis. Histopathology, though confirmatory, demands an astute interpretational skill. Diagnosis of follicular psoriasis can have therapeutic implications.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"127-132"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Response to Diphenylcyclopropenone in Patients with Alopecia Totalis/Universalis.","authors":"Smitha Ancy Varghese, Sandhya S Nair, Anuja Elizabeth George, Induprabha Yadev","doi":"10.4103/ijt.ijt_2_22","DOIUrl":"10.4103/ijt.ijt_2_22","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia totalis (AT) and Alopecia universalis (AU) are forms of Alopecia areata (AA) which represent the strongest predictor of poor prognosis since spontaneous regrowth is <10%. Topical immunotherapy agent, diphenylcyclopropenone (DPCP) has shown clinical efficacy with limited side effects in severe forms of AA. However, its specific role in AT/AU characterized by complete hair loss over the scalp can help highlight the efficacy of the drug with fewer confounders.</p><p><strong>Methodology: </strong>Data were collected from 18 patients diagnosed with AT/AU and treated with topical immunotherapy with DPCP as per protocol by Happle <i>et al</i>. Baseline Severity of Alopecia Tool (SALT) score and subclass was recorded. In the case of AU, baseline body hair loss score was also recorded. Patients were reassessed after 6 months of treatment in terms of change in SALT score and hair regrowth was assessed using the Global Assessment Score. The side effects during treatment were also assessed and recorded.</p><p><strong>Results: </strong>Eighteen patients of whom eleven (61.1%) were diagnosed as AU and seven (38.9%) as AT were treated. The mean age was 21.6, with a male: female ratio of 3:2. The comorbidities noted were atopy in six (33.3%), atopy and hypothyroidism in one (5.5%), Down's syndrome in two (11.1%), and hypothyroidism alone in one (5.5%) patient. The mean duration of disease at the time of presentation was 3 years and all patients had remained refractory to various other modalities of treatment. All patients had a baseline SALT score of 100 corresponding to S5. After 6 months of treatment, 27.7% of patients did not show any response (SALT score S5), 16.6% had a score of S4, 11.1% had a score of S3, 11.1% had a score of S2, 22.2% had a score of S1, and 11.1% had a score of S0. On assessing improvement in body hair loss score, 36.3% of patients showed no improvement, 36.3% showed partial improvement, and 27.2% of patients showed complete body hair regrowth. About 55.5% of patients developed notable side effects that included severe local reactions, cervical lymphadenopathy, acne and pigmentation at the site of application as well as untreated sites.</p><p><strong>Conclusion: </strong>The AT/AU subtypes of AA, was amenable to treatment with contact immunotherapeutic agent DPCP with a >75% hair regrowth in 33.3% of patients. The castling phenomenon was seen in 63.6% of AU patients. The adverse effects noted were not severe enough to deter treatment.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"149-153"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichoscopy Features of Indonesian Males with Androgenetic Alopecia in Association with Disease Severity.","authors":"Lili Legiawati, Lis Surachmiati Suseno, Irma Bernadette S Sitohang, Shannaz Nadia Yusharyahya, Athaya Ardelia, Kanya Paramastri","doi":"10.4103/ijt.ijt_31_22","DOIUrl":"10.4103/ijt.ijt_31_22","url":null,"abstract":"<p><strong>Introduction: </strong>Androgenetic alopecia (AGA) is a progressive loss of terminal hairs in a specific pattern distribution related to androgen. The dermoscopy of hair and scalp, known as trichoscopy, is a noninvasive method for diagnosing alopecia and other hair and scalp disorders.</p><p><strong>Objective: </strong>This study aims to report the correlation between the severity of males with AGA based on Hamilton-Norwood's scale with the clinical characteristics found in trichoscopy.</p><p><strong>Materials and methods: </strong>This study included 40 patients aged 25-58 years who visited the dermatology outpatient clinic in a tertiary health facility in Indonesia. Clinical diagnosis was determined through history taking, physical examination, and trichoscopy. Based on Hamilton-Norwood's criteria, patients were divided into two groups: early and late stage. Parameters examined in trichoscopy include yellow dots, white dots, peripilar sign, vellus hair, hair diameter diversity, single-hair follicles, and empty follicles. The Chi-square test and Fisher's exact test were used to analyze the statistical significance between the groups.</p><p><strong>Results: </strong>All participants presented with hair diameter diversity, vellus hair, and empty follicles (100%). None of the study participants had yellow dots. White dots and single-hair follicles were seen in 32 (80%) and 30 cases (75%), respectively. In the late-stage group, these features were more prevalent. Peripilar sign was found in 25 participants (62.50%), and it was more common in the early-stage group. No significant association was found between disease severity and trichoscopy features.</p><p><strong>Conclusion: </strong>The most common trichoscopy findings in particular order were hair diameter diversity, vellus hair, and empty follicles, followed by white dots, single-hair follicles, and peripilar signs. No significant association between alopecia severity and trichoscopy parameters was observed. Studies with a larger number of participants, including a control group, should be conducted to yield more significant results.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"144-148"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Focused Pulling Type of Trichotillomania Presenting as Dermatological Pathomimicry.","authors":"Ipsita Debata, Debasmita Behera, Chinmoy Raj, Abhishek Lachure","doi":"10.4103/ijt.ijt_53_22","DOIUrl":"10.4103/ijt.ijt_53_22","url":null,"abstract":"<p><p>Nonhealing ulcers are defined as spontaneous or traumatic lesions, unresponsive to initial therapy, or which persist despite appropriate care. Trichotillomania (TTM) is an impulse control disorder, where severe form may cause ulcer and scarring. After extensive research, we could not find any case showing the association of TTM with large-sized factitious ulcer. Hence, we report a rare case of 30 year old female presenting with TTM and large sized factitious ulcer.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"169-172"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth Factor Cocktail Including Fibroblast Growth Factor 9 (Cellcurin) in the Treatment of Androgenetic Alopecia in Men and Women: A Randomized Controlled Trial.","authors":"Leonardo de Medeiros Quirino, Giovana Vilela Rocha","doi":"10.4103/ijt.ijt_39_21","DOIUrl":"10.4103/ijt.ijt_39_21","url":null,"abstract":"<p><strong>Objectives: </strong>Androgenetic alopecia (AGA) is the most common cause of hair loss in men and women, affecting about 30% of men and 15% of women at 30 years and 80% and 48% at 70 years, respectively. This study aims to assess the effectiveness of growth factor cocktail therapy including fibroblast growth factor 9 (FGF9) (Cellcurin) in men and women with AGA.</p><p><strong>Materials and methods: </strong>This is a single-center randomized controlled trial, conducted with 10 men and 10 women with AGA. Eight men participated in the therapeutic group and two men in the control group. Eight women participated in the therapeutic group and two women in the control group. All were classified by sex, age, duration, and degrees of progression of AGA. The study obtained approval from the Research Ethics Committee (REC) of the Federal University of Uberlandia at approval number: 36918620.8.0000.5152. Six microneedling sessions were performed with an electromedical pen with an interval of 15 days between sessions. In the therapeutic group, sterile injectable Cellcurin was used and, in the control group, injectable sterile minoxidil 5 mg/ml 2 ml, both through the drug delivery system. Trichoscopic photos were taken before and after 12 weeks in the frontal and vertex regions. Descriptive statistics were performed using the <i>t</i>-test with the IBM SPSS-25 software.</p><p><strong>Results: </strong>Men and women showed an expressive and significant increase in the amount of hair per cm² after Cellcurin therapy, as well as an increase in the amount of terminal hair, vellus hair, sum of the terminal hair diameters, and mean of the terminal hair diameters in both regions, frontal and vertex.</p><p><strong>Conclusions: </strong>In this study, we demonstrated that the use of Cellcurin in the treatment of AGA in men and women is associated with an increase in the amount of hair per cm², in the amount of terminal hair per cm², in the amount of vellus hair per cm², in the number obtained by the sum of the terminal hair diameters per cm², as well as an increase in the mean diameter of the terminal hairs.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"133-143"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plica Neuropathica in Infancy.","authors":"Bhavya Sangal","doi":"10.4103/ijt.ijt_56_22","DOIUrl":"10.4103/ijt.ijt_56_22","url":null,"abstract":"<p><p>Plica neuropathica is an acquired hair disorder characterized by matted hair locks. We report a case of plica neuropathica in infancy, where due to repeated washing of hair without combing led to matted hair nest on the scalp. We report this case due to its rare occurrence.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"167-168"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A puzzling Presentation of Alopecia Areata: Sudden-Onset Whitening of Hair and its Spontaneous Resolution.","authors":"Gizem Pehlivan, Algün Polat Ekinci, Şule Öztürk Sarı","doi":"10.4103/ijt.ijt_6_22","DOIUrl":"10.4103/ijt.ijt_6_22","url":null,"abstract":"<p><p>A 39-year-old male presented with the complaint of sudden onset and progressive whitening of the scalp hair. The patient documented the situation by regularly taking selfies starting from the moment he noticed that his hair was starting to turn white. A diagnosis of alopecia areata involving pigmented hair was made with clinical, dermoscopic, histopathological, and immunofluorescence findings. Total regrowth of the pigmented hair was observed at 6 months follow-up without any systemic treatment.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"157-159"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Potpourri of Trichoscopic Findings: Unique Presentation of Hyperthyroidism-Induced Hair Changes.","authors":"Vrushali Jaysing Salve, Vishalakshi Viswanath, Pradnya Joshi, Mayuri Dhakne","doi":"10.4103/ijt.ijt_98_21","DOIUrl":"10.4103/ijt.ijt_98_21","url":null,"abstract":"<p><p>Hyperthyroidism is known to cause thin, brittle hair, and premature graying. Hair shaft abnormalities in hyperthyroidism have not been described in the literature. A visible and microscopic change in the hair shaft due to cosmetic procedures and environmental factors is known as hair weathering. Herein, we report a case of hair weathering in an adult female with hyperthyroidism with unique dermoscopic features.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"160-162"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}