International Journal of Trichology最新文献

{"title":"Positioning of Low Alcohol or Alcohol-Free Minoxidil Formulation for the Management of Androgenetic Alopecia: Indian Perspective.","authors":"Satish Udare,&nbsp;Anita Baruah,&nbsp;Anurag Mathur,&nbsp;T R Dayananda,&nbsp;Kapil Jain,&nbsp;Manas Ranjan Puhan,&nbsp;Pawan Bajaj,&nbsp;Richa Sharma,&nbsp;Sanjay Ramanbhai Gamit,&nbsp;V Ramesh,&nbsp;V Venugopal,&nbsp;Vignesh Karthik,&nbsp;Monil Yogesh Neena Gala,&nbsp;Snehal Muchhala,&nbsp;Amey Mane","doi":"10.4103/ijt.ijt_54_22","DOIUrl":"10.4103/ijt.ijt_54_22","url":null,"abstract":"<p><p>Topical minoxidil is used for treating different hair disorders. Even though it is an effective therapy, many patients show poor compliance due to the cost, side effects, and duration of treatment. Topical minoxidil is the mainstay treatment for androgenetic alopecia (AGA). Recently, low alcohol or alcohol-free topical minoxidil formulation has proven to be an alternative for patients suffering from AGA, including those with poor compliance with other therapies. Thus, the current article provides the positioning of low alcohol or alcohol-free topical minoxidil to manage AGA in Indian clinical practice.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 1","pages":"13-17"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9674239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Updated Review on Current Treatment of Alopecia Areata and Newer Therapeutic Options.","authors":"Karan Malhotra,&nbsp;Bhushan Madke","doi":"10.4103/ijt.ijt_28_21","DOIUrl":"10.4103/ijt.ijt_28_21","url":null,"abstract":"<p><p>Alopecia areata (AA) is a dermatological disease that causes nonscarring hair loss. It can occur at any age and has an unpredictable and variable evolution in individuals. The aim of this review is to provide an update on the novel therapies currently being used, as well as upcoming therapeutic options in the treatment of AA.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 1","pages":"3-12"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9621266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slivers of Hair - A Clue to Uncover Silver Hair Syndromes.","authors":"Nivetha Ganeshan,&nbsp;Muthukumaran Rajaram,&nbsp;Madhavan Ramamoorthy,&nbsp;Bharathi Sukumar","doi":"10.4103/ijt.ijt_181_20","DOIUrl":"10.4103/ijt.ijt_181_20","url":null,"abstract":"<p><p>Silver hair syndromes (SHS) consist of rare autosomal recessive disorders, Chediak-Higashi syndrome (CHS), Griscelli syndrome (GS), and Elejalde disease. CHS is a disorder of vesicle trafficking; characterized by silvery hair, diffuse pigment dilution, immunodeficiency, bleeding diathesis, neurological manifestations, and an accelerated phase due to lymphohistiocytic infiltration. GS is characterized by hypopigmentation of skin and hair, with large clumps of pigment in the hair shaft. There are three types of GS. GS1 and GS2 show neurologic and hematologic impairments; GS3 is restricted to the skin. Some authors suggest that Elejalde syndrome is synonymous with GS Type 1. Here, we report two cases who presented with silver-gray hair but with varied clinical manifestations. With a light microscopic examination of the hair and peripheral smear, a diagnosis has been made. This report highlights the importance of hair shaft microscopy, an inexpensive, noninvasive, and simple tool in the diagnosis of SHS.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 1","pages":"36-38"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9674240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair Regrowth with Novel Hemp Extract: A Case Series.","authors":"Gregory Luke Smith","doi":"10.4103/ijt.ijt_34_22","DOIUrl":"10.4103/ijt.ijt_34_22","url":null,"abstract":"<p><strong>Introduction: </strong>The endocannabinoid system (ECS), discovered in the 1990s, is a system involved with maintaining cellular homeostasis by down-regulating the damaging inflammatory responses and upregulating regenerative processes. Cannabidiol (CBD), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV) are all phytocannabinoids found in varying quantities in hemp extract. These three cannabinoids have novel therapeutic effects on hair regrowth through the ECS. The method of action is different from and synergistic with current hair regrowth therapies. The three cannabinoids are fat-soluble and poorly absorbed past the epidermis, but topical application easily reaches hair follicles where they act as partial or full CB1 antagonist and agonist of transient receptor potential vanilloid-1 (TRPV1) and vanilloid receptor-4 (TRPV4). All these ECS receptors relate to hair follicle function. Blocking the CB1 receptor on the hair follicle has been shown to result in hair shaft elongation; in addition, the hair follicle cycle (anagen, catagen, and telogen phases) is controlled by TRPV1. The effects of CBD on hair growth are dose dependent and higher doses may result in premature entry into the catagen phase through a different receptor known as TRPV4. CBD has also been shown to increase Wnt signaling, which causes dermal progenitor cells to differentiate into new hair follicles and maintains anagen phase of the hair cycle.</p><p><strong>Objective: </strong>This study was conducted on subjects with androgenetic alopecia (AGA), as follow-up to a prior published study using hemp extract high in CBD without CBDV or THCV. That study showed an average 93.5% increase in hair numbers after 6 months of use. This subsequent study is being done to determine if daily topical application of a hemp-oil high in CBD, THCV, and CBDV concentrations would result in improved hair regrowth in the area of the scalp most affected by AGA.</p><p><strong>Materials and methods: </strong>A case series study was done of 31 (15 men and 16 women, 27 Caucasian, 2 Asian, and 1 mixed race) subjects with AGA. They used a once-daily topical hemp extract formulation, averaging about 33 mg/day for 6 months. A hair count of the greatest area of alopecia was carried out before treatment was started and again after 6 months of treatment. To facilitate consistent hair count analysis, a permanent tattoo was placed at the point for maximum hair loss on the scalp. The subjects were also asked to qualitatively rate their psychosocial perception of \"scalp coverage\" improvement after the study was completed. The qualitative scale included \"very unhappy,\" \"unhappy,\" \"neutral,\" \"happy,\" and \"very happy.\" The subjects were photographed in a standard manner before and after the study. The photographs were compared for improvements in \"scalp coverage\" by an independent physician. The qualitative scale included \"none,\" \"mild,\" \"moderate,\" and \"extensive\" improvement of scalp coverage.</p><p","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 1","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9976421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesotherapy with Bicalutamide: A New Treatment for Androgenetic Alopecia.","authors":"Alba Gomez-Zubiaur,&nbsp;Juan Jose Andres-Lencina,&nbsp;Víctor Cabezas,&nbsp;Cristina Corredera,&nbsp;Fabio di Brisco,&nbsp;Blanca Ferrer,&nbsp;Ana Rodriguez-Villa,&nbsp;Daniela Subiabre-Ferrer,&nbsp;Cristian Valenzuela,&nbsp;David Vega Diez,&nbsp;Jose Maria Ricart","doi":"10.4103/ijt.ijt_78_21","DOIUrl":"10.4103/ijt.ijt_78_21","url":null,"abstract":"<p><p>Bicalutamide is a selective androgen receptor antagonist. To date, it has been used orally with good efficacy results, but not in mesotherapy. In our center, we assessed whether patients undergoing bicalutamide mesotherapy showed positive responses and tolerated the local administration of bicalutamide. Six premenopausal women, with a mean age of 35.7 years and clinical diagnosis of Olsen Grade II or III female androgenetic alopecia accompanied by significant seborrhea were treated with 1 ml bicalutamide 0.5% mesotherapy. Three monthly sessions were performed. A subtle improvement in hair density was described after the third session. The overall satisfaction of the patients with the treatment was 6.3, on a scale of 1-10. Premenopausal women require several therapeutic approaches to combat severe androgenetic alopecia. Our data showed that bicalutamide mesotherapy was well tolerated and welcomed by the patients; we, therefore, provide a new tool for the management of this pathology.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 1","pages":"39-40"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9621269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Low-Level Laser Therapy in Androgenetic Alopecia - A Randomized Controlled Trial.","authors":"Dharm Mansukh Sondagar,&nbsp;Hita H Mehta,&nbsp;Rashmiben Sabbirali Agharia,&nbsp;Milan K Jhavar","doi":"10.4103/ijt.ijt_5_22","DOIUrl":"10.4103/ijt.ijt_5_22","url":null,"abstract":"<p><strong>Background: </strong>Androgenetic alopecia (AGA) is caused by the susceptibility of hair follicles to androgenic miniaturization, which leads to hair loss. The most common modalities for the treatment of AGA include the use of topical minoxidil and oral finasteride. Low-level laser therapy (LLLT) is a newer modality of treatment for AGA. We tried to evaluate the added benefit of LLLT in AGA compared with topical minoxidil 5% alone.</p><p><strong>Aim: </strong>The aim of this study was to compare the efficacy of LLLT combined with topical 5% minoxidil in AGA versus topical 5% minoxidil used alone.</p><p><strong>Materials and methods: </strong>After ethics committee approval, 54 patients of AGA were randomly divided into two groups. Group A participants received LLLT therapy twice a week plus topical 5% minoxidil and Group B participants received only minoxidil 5% solution. Both the groups were followed up for 16 weeks and evaluated with gross photographs, TrichoScan analysis, and dermoscopy to look for any improvement in hair density.</p><p><strong>Results: </strong>After 16 weeks, improvement in hair density of 14.78% ± 10.93% in Group A was recorded compared to 11.43% ± 6.43% in Group B. However, while comparing both means, <i>P</i> value was 0.45 which was not significant. The physician global assessment and patient satisfaction score revealed no significant difference between both the groups.</p><p><strong>Conclusion: </strong>Although LLLT appears to be safe and effective in the treatment of male pattern hair loss, we did not observe any significant difference in terms of improvement in hair density between both the groups.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 1","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9674241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ignorism.","authors":"Ralph Michel Trüeb","doi":"10.4103/ijt.ijt_125_21","DOIUrl":"10.4103/ijt.ijt_125_21","url":null,"abstract":"","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9674242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon Foot Pain: A Rare Case of Sequential Migration of Cutaneous Pili Migrans.","authors":"Kelsen Dos Santos Sales,&nbsp;Anacélia Gomes de Matos Mota,&nbsp;Camilla Teixeira Pinheiro Gusmão,&nbsp;Howard Lopes Ribeiro Junior","doi":"10.4103/ijt.ijt_4_21","DOIUrl":"10.4103/ijt.ijt_4_21","url":null,"abstract":"<p><p>Cutaneous pili migrans (CPM) is an uncommon condition in which a hair fragment penetrates the skin and produces a creeping lesion similarly of cutaneous larva migrans associated with local pain. There are few reports of CPM in the literature, and none visually describes the migration of the hair shaft in the epidermis associated with pain. Herein, we showed the first report describing a case of an <i>in situ</i> sequential migration of CPM in an adult patient.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 1","pages":"33-35"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9674243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ichthyosis Follicularis with Alopecia and Photophobia Syndrome with Coexisting Palmoplantar Keratoderma Treated with Acitretin.","authors":"Supriya Rajesh,&nbsp;Eswari Loganathan,&nbsp;Asha Gowrappala Shanmukhappa","doi":"10.4103/ijt.ijt_9_22","DOIUrl":"10.4103/ijt.ijt_9_22","url":null,"abstract":"<p><p>Ichthyosis follicularis with alopecia and photophobia (IFAP) syndrome is a rare congenital genetic disorder characterized clinically by a triad of follicular ichthyosis, alopecia and photophobia. The genetic inheritance pattern in IFAP syndrome is said to be X-linked with mutations of the membrane-bound transcription factor peptidase, site 2 gene. Histopathology of the skin shows dilated hair follicles with keratin plugs extending above the surface of the skin. In this case report, we describe a 6-year-old girl with clinical features of IFAP along with palmoplantar keratoderma. Skin biopsy was done to confirm the diagnosis after which she was started on acitretin (10 mg per day). Good improvement in cutaneous features was observed after 1 month.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"14 6","pages":"213-215"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9642099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversal of Premature Hair Graying Treated with a Topical Formulation Containing <i>α</i>-Melanocyte-Stimulating Hormone Agonist (Greyverse Solution 2%).","authors":"Dipali Chavan","doi":"10.4103/ijt.ijt_85_22","DOIUrl":"10.4103/ijt.ijt_85_22","url":null,"abstract":"<p><p>With aging, hair graying is a common sign resulting from complex regulation of melanogenesis. Multiple factors control the stimulation of melanogenesis at the level of the hair follicle, including melanin-stimulating hormone (MSH), adrenocorticotropic hormone, endothelin-1, prostaglandins, leukotrienes, neutrophils, fibroblast growth factor, nitric oxide, catecholamines, Vitamins, and minerals. Premature hair graying (PHG) has a major impact on the cosmesis, self-credibility, and social life of the affected individual. Currently, there is no medical treatment available for PHG. We present a case of a 25-year-old female with a history of graying of hair on the scalp. Clinical diagnosis revealed it as a case of premature graying/canities. She was prescribed a topical formulation (Greyverse solution) containing palmitoyl tetrapeptide 20, a biomimetic biopeptide of <i>α</i>-MSH for treating her PHG. The formulation was applied 1 mL twice daily directly on the affected part of the scalp. Hair supplements containing a combination of biotin and calcium pantothenate once daily orally were also prescribed. After 3 months, the patient showed some improvement, and the dose of the topical solution was reduced to 1 mL once daily. After 5 months, the patient achieved >90% conversion of gray hair to black hair.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"14 6","pages":"207-209"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9642102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}