International Journal of Trichology最新文献

{"title":"Platelet-Rich Plasma in Androgenetic Alopecia: Is It Really Worth the Hype?","authors":"Pooja Agarwal, Krishna M Gajjar, Ashish Jagati, Snehal V Chaudhari, Santoshdev P Rathod","doi":"10.4103/ijt.ijt_31_21","DOIUrl":"10.4103/ijt.ijt_31_21","url":null,"abstract":"<p><strong>Introduction: </strong>Androgenetic alopecia (AGA) is defined as progressive, patterned hair loss that occurs as a result of androgen-mediated conversion of terminal hairs to vellus hairs. By the age of 60 years, 45% of men and 35% of women develop AGA. The Hamilton-Norwood scale is used to assess the extent and severity of AGA and classify the stages of male pattern hair loss in men, whereas the Ludwig scale is preferred for women. Currently, U.S. Food and Drug Administration-approved treatments for AGA include oral finasteride and topical minoxidil. Due to the limited number of effective therapies for AGA, platelet-rich plasma (PRP) has become an effective alternative treatment. A number of studies on PRP have shown promising results, leading to increased hair density and thickness with minimal or no side effects.</p><p><strong>Aims: </strong>We aim to study the safety, efficacy, and side effects of PRP therapy in patients of AGA and to study demographic data in the form of age, sex, age of onset of hair loss, and grade of AGA in patients.</p><p><strong>Materials and methods: </strong>Fifty patients, 38 males and 12 females, with AGA were enrolled in the study. PRP was prepared using a double-spin method. Upon activation, PRP was injected in the involved areas of scalp once every 2 weeks for 6 months. Follow-up photos were taken every 3 months.</p><p><strong>Results: </strong>At 6 months, majority of the patients (45%) were unsatisfied and showed no change in hair growth after PRP therapy and few patients were lost in follow-up. Adverse effects were minimal and no long-term serious adverse effects were noted.</p><p><strong>Conclusion: </strong>We conclude from the results in our study that PRP therapy is not significantly effective in treatment of AGA. There is a need to develop standard protocols with regard to total length of PRP therapy and spacing between the two sessions of PRP for AGA.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 3","pages":"98-104"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10763730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Problem with Capitalism in the Trichological Sciences.","authors":"Ralph Michel Trüeb, Aida Gadzhigoroeva, Daisy Kopera, Ngoc-Nhi Catharina Luu, Angelina Dmitriev","doi":"10.4103/ijt.ijt_15_23","DOIUrl":"10.4103/ijt.ijt_15_23","url":null,"abstract":"<p><p>Karl Marx and Friedrich Engels exposed a pattern of societal conduct they chose to name capitalistic bourgeoisie. The bourgeoisie created a common language of communication through collaboration, gathered in circles such as free academies, scientific academies, literary circles, and the media, that provided forums for the emerging bourgeoisie to conceive of new social orders. One aspect of bourgeoisie culture is conspicuous consumption, central to which, is a culture of prestige through material consumption. Capitalism is an economic system based on private ownership and the operation for profit. Characteristic features of capitalism include competitive market, commercialism, property rights recognition, capital accumulation, material consumption, culture of prestige, sycophancy, and coterie. Critiques of capitalism allege that it is exploitative, alienating, unstable, unsustainable, and inefficient. In turn, critical theory inspired philosophers such as Michel Foucault to conceptualize how we form identities through social interaction. When the patient's body entered the field of medicine, it also entered the field of power where the patient can be manipulated by professional authority. Without forcibly being a proponent of political theory, as an academic, one is inevitably confronted with Marxism in terms of philosophy. As a discipline at the interface of medicine, lifestyle, and cosmetics, trichology is particularly susceptible to the primary aims of profit, consumption, and prestige that characterize the capitalistic bourgeoisie. The trichological sciences, particularly trichoscopy, have discovered a profitable market for itself. The practice of trichology is not immune to malpractice. It has created an industry that dwells on the autistic thinking of patients and doctors, and because it is prosperous, makes propaganda among lay people and doctors that necessarily leads to abuses.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 3","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10763731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repigmentation of Segmental Vitiligo with Scalp and Pubic Follicular Unit Extraction Graft Transplantation.","authors":"Jisha Pillai,&nbsp;Nilesh Goyal","doi":"10.4103/ijt.ijt_41_22","DOIUrl":"10.4103/ijt.ijt_41_22","url":null,"abstract":"<p><p>Segmental vitiligo (SV) has been identified as a type of vitiligo starting early on in life with a rapidly progressive depigmentation in the affected area. Surgical modalities have shown better outcomes in SV compared with medical therapies. Perifollicular repigmentation being the mode of pigment spread after surgical treatments, follicular unit extraction graft surgery has shown complete repigmentation with minimal postoperative scarring. We present a case of SV where hair transplant surgery was done using scalp hair and pubic hair grafts at different times achieving complete repigmentation with photochemotherapy.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 2","pages":"70-73"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10239702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of Topical Finasteride (0.25%) in Combination with Minoxidil (5%) Against 5% Minoxidil or 0.25% Finasteride Alone in Male Androgenetic Alopecia: A Pilot, Randomized Open-Label Study.","authors":"Apoorva V Bharadwaj,&nbsp;Vibhu Mendiratta,&nbsp;Harmeet Singh Rehan,&nbsp;Smita Tripathi","doi":"10.4103/ijt.ijt_72_22","DOIUrl":"10.4103/ijt.ijt_72_22","url":null,"abstract":"<p><strong>Background: </strong>Androgenetic alopecia (AGA) is the most common cause of hair loss in males which remains a therapeutic challenge.</p><p><strong>Objectives: </strong>To compare the efficacy of topical 5% minoxidil and 0.25% finasteride combination (MNF) over 5% minoxidil (MNX) or 0.25% finasteride (FNS) alone by assessing hair count, physician assessment score (PAS), and patient satisfaction score (PSS).</p><p><strong>Materials and methods: </strong>Pilot randomized open-label study where 60 male patients with AGA ≥ III grade were randomized into three treatment groups and evaluated over 24 weeks. Improvement in hair count was assessed manually using dermoscopy. Global photographs were used to assess PAS. Side effects were evaluated using relevant laboratory investigations.</p><p><strong>Results: </strong>At the 12^th and 24^th week, all three groups showed significant improvement in total hair density as compared to baseline (<i>P</i> < 0.001). None of the groups was superior to the other (<i>P</i> > 0.05) at the 12^th week but at 24^th week, MNF was comparatively superior (<i>P</i> < 0.02). At the 12^th week and 24^th week, all three groups showed significant improvement in terminal hair density as compared to baseline (<i>P</i> < 0.001). In the 12^th week, MNF was comparatively superior (<i>P</i> = 0.028) and at the 24^th week, MNF was comparatively superior (<i>P</i> < 0.02). PAS and PSS were significantly better with MNF and MNX compared to FNS (<i>P</i> < 0.004). Side effects such as scaling and itching were reported with MNF and MNX.</p><p><strong>Conclusion: </strong>Topical minoxidil 5% and finasteride 0.25% had an overall better efficacy compared to monotherapy without significant side effects.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 2","pages":"56-62"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10244519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commonly Associated Disorders with Complete Scalp Alopecia in Early Childhood: A Review.","authors":"Michaela Rose Rand,&nbsp;Katerina Yale,&nbsp;Brian Satoshi Kato,&nbsp;Dong Joo Kim,&nbsp;Suzanne Birmingham,&nbsp;Natasha Atanaskova Mesinkovska","doi":"10.4103/ijt.ijt_70_22","DOIUrl":"10.4103/ijt.ijt_70_22","url":null,"abstract":"<p><p>Complete scalp hair loss can be a source of distress for affected children and their families. In addition to infectious and trauma-related causes of hair loss, infants and children may present with total scalp alopecia arising from a range of genetic predispositions. Our objective with this review was to identify the common genetic conditions in children with complete scalp alopecia. The PubMed Database was reviewed for all articles from 1962 to 2019 containing the search terms related to genetic alopecia. The conditions with at least five reported cases in the literature were considered for the inclusion. All clinical trials, retrospective studies, and cases on human subjects and written in English were included. Six genetic conditions related to complete scalp alopecia were included in this review. The most common genetic conditions associated with total scalp hair loss include: alopecia totalis/Alopecia universalis (AU), atrichia with papular lesions, AU congenita, hereditary Vitamin D-resistant rickets type IIA, alopecia with mental retardation, and pure hair and nail ectodermal dysplasia. In children presenting with total scalp hair loss, a myriad of genetic and environmental factors may be the underlying cause. Increased awareness of potential genetic conditions associated with total scalp hair loss may assist in diagnosis, with improved the prognosis for the children.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 2","pages":"43-49"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10232604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Localized Hypertrichosis in Conjunction with Erythema Nodosum.","authors":"Yeon Seok Lee,&nbsp;June Hyunkyung Lee,&nbsp;Tae Young Han,&nbsp;Jae Eun Choi","doi":"10.4103/ijt.ijt_167_20","DOIUrl":"10.4103/ijt.ijt_167_20","url":null,"abstract":"<p><p>Acquired hypertrichosis can occur in local inflammation. Erythema nodosum (EN) is a hypersensitivity reaction to various underlying antigenic stimuli including <i>Mycobacterium tuberculosis</i>, which causes inflammation in the septa of subcutaneous fat. There were several case reports that describe the association of localized hypertrichosis (LH) with traumatic panniculitis and lupus panniculitis. To our knowledge, this is the first reported case of acquired LH associated with EN. Thus, EN can be added to the list of causes of localized hypertrichosis.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 2","pages":"74-76"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10232610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cemiplimab-Induced Alopecia Areata.","authors":"Bianca Maria Piraccini,&nbsp;Francesca Comito,&nbsp;Barbara Melotti,&nbsp;Ignazio Stanganelli,&nbsp;Metelda Medri,&nbsp;Francesco Savoia","doi":"10.4103/ijt.ijt_107_21","DOIUrl":"10.4103/ijt.ijt_107_21","url":null,"abstract":"","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 2","pages":"77-78"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study of Correlation of Alopecia Areata and Metabolic Syndrome in Northwest Indian Population: A Case-Control Study.","authors":"Heena Singdia,&nbsp;Puneet Bhargava,&nbsp;Shivi Nijhawan,&nbsp;Deepak Kumar Mathur","doi":"10.4103/ijt.ijt_89_21","DOIUrl":"10.4103/ijt.ijt_89_21","url":null,"abstract":"<p><strong>Context: </strong>Alopecia areata (AA) is the most common cause of inflammatory, nonscarring hair loss, involving hair-bearing areas of the body. The etiology of AA still remains uncertain; however, genetic, environmental, and autoimmunity play a role. Newer theories such as oxidative theory, HPA axis activation, and finally, the role of increased inflammatory cytokines such as interleukin 1 (IL1), tumor necrosis factor-alpha, interferon-gamma, IL-2 IL-4, and MIF are suggested to contribute to both AA and metabolic syndrome (MS).</p><p><strong>Aims: </strong>Assessment of the degree of association of MS (NCEP ATP III criteria) in clinically diagnosed cases of AA and compare to that of controls.</p><p><strong>Materials and methods: </strong>Similar age/sex-matched AA patients and controls (106 in each group) were taken. Anthropometric measurements, blood-sugar estimation, lipid-profile estimation in venous blood sample, and blood-pressure measurement were done.</p><p><strong>Results: </strong>Prevalence of MS was almost similar among cases of AA 9/106 (8.47%) as well as healthy controls 8/106 (7.54%), and the difference was not statistically significant (<i>P</i> = 1). Among all components of MS, waist circumference (WC) (central obesity) was the most common parameter (100% cases). In controls, high systolic blood pressure (SBP) was the most common parameter (77.78% controls). AA is associated with a higher level of SBP, diastolic blood pressure (DBP), WC although nonsignificant, and low level of high-density lipoprotein cholesterol which was the only significant association.</p><p><strong>Conclusion: </strong>Insignificant correlation between occurrence of MS and evidence of insulin resistance (IR) in AA was observed in this study population. However, some of the observations in the present study may raise awareness in susceptible individuals that lifestyle changes and regular screening in AA can reduce the risk of cardiovascular diseases and other co-existing autoimmune inflammatory condition-IR, dyslipidemia, and hypertension.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 2","pages":"63-69"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Platelet-Rich Plasma and other Key Factors on Hair Follicle Preservation.","authors":"Rattapon Thuangtong,&nbsp;Pichanee Chaweekulrat,&nbsp;Kanchalit Thanomkitti,&nbsp;Daranporn Triwongwaranat,&nbsp;Chuda Rujitharanawong","doi":"10.4103/ijt.ijt_65_22","DOIUrl":"10.4103/ijt.ijt_65_22","url":null,"abstract":"<p><strong>Background: </strong>Hair graft preservation is an important factor that influences graft survival in hair transplantation.</p><p><strong>Objective: </strong>To investigate the benefits of adding platelet-rich plasma (PRP), and the effect of different storage solutions and temperatures on hair follicle preservation.</p><p><strong>Materials and methods: </strong>This randomized-controlled study included 10 androgenetic alopecia patients who underwent hair transplantation. Forty-five hair grafts were collected from each patient and then randomized to 8 different culture conditions for 7 days. Hair grafts were cultured in Williams' Medium E or Ringer's lactate solution (RLS) at either 4°C or 37°C, and with or without 10% PRP supplementation.</p><p><strong>Results: </strong><i>In vitro</i> hair growth in Williams' Medium E was significantly greater than in RLS. The 37°C temperature condition was found to be significantly better than the 4°C condition. The growth of hair grafts cultured with PRP was not significance difference from those without PRP. However, immunofluorescence staining for cytokeratin 15 showed greater expression in hair graft cultured with PRP.</p><p><strong>Conclusion: </strong>PRP may have a beneficial effect for preserving the viability of hair grafts. Williams' Medium E and 37°C temperature were found to be superior to RLS and 4°C relative to hair follicle growth in organ culture.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 2","pages":"50-55"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10239700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposition of a New Terminology of Senile Alopecia: Physiologic Alopecia.","authors":"Yazid Bourezane,&nbsp;Ines Bourezane","doi":"10.4103/ijt.ijt_54_21","DOIUrl":"10.4103/ijt.ijt_54_21","url":null,"abstract":"","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 1","pages":"41-42"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9976427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}