International Journal of Surgical Pathology最新文献

{"title":"The Positive Immunohistochemical Staining of Cytomegalovirus in Colon Biopsy Samples Suggests That the Viral DNA Load in qPCR Is High.","authors":"Guanglan Wang, Jianmin Zhao, Junchang Jiang, Aihua Huang, Lingna Ye, Zhinong Jiang","doi":"10.1177/10668969251339808","DOIUrl":"10.1177/10668969251339808","url":null,"abstract":"<p><p>Background and AimImmunohistochemistry (IHC) and/or polymerase chain reaction (PCR) are essential for confirming active cytomegalovirus (CMV) infection in patients with inflammatory bowel disease (IBD). A definitive cut-off has not yet been established; however, Roblin et al suggested a viral load threshold of > 250 viral copies/mg of tissue. In this study, we examined the concordance between IHC and quantitative real-time PCR (qPCR) in the detection of CMV in colonic biopsy specimens.MethodsA total of 170 samples that underwent IHC and qPCR were collected. The positive rate and concordance of IHC and qPCR were studied, and the impact of ulcer tissue on both detection methods was observed.ResultsIn a study of 170 hematoxylin-eosin (H&E) sections, 8 samples were found to be infected with cytomegalovirus. The positive rates of CMV detection using IHC and qPCR were 17% (29/170) and 25% (43/170), respectively. Among the IHC-positive samples, the qPCR positive rate was 100% (29/29), with all CMV-DNA loads > 250 copies/mg. The concordance between IHC and qPCR was 94% (kappa = 0.756, <i>P</i> < .001). IHC analysis revealed that positive cells in ulcerated mucosa were more frequent than those in nonulcerated mucosa (<i>P</i> < .001). Additionally, a total of 14 samples tested negative for CMV via IHC but positive through qPCR. Among these, 11 samples did not contain ulcerated tissue.ConclusionThe presence of one or more IHC-positive cells in colon biopsy samples indicates a high CMV-DNA load in qPCR (> 250 copies/mg). IHC-positive cells were more frequently observed in ulcerated mucosa compared to nonulcerated mucosa.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1752-1758"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polythelia (Supernumerary Nipple): Clinicopathological Characterization of an Atavistic Lesion.","authors":"Majd Al Assaad, Diana R Vulcain, Andy Phan, Baris Boyraz, Syed A Hoda","doi":"10.1177/10668969251338577","DOIUrl":"10.1177/10668969251338577","url":null,"abstract":"<p><p>Polythelia refers to the presence of additional nipples typically located along the \"milk line.\" While its atavistic nature and associations with congenital anomalies are well documented, its clinicopathological features are less defined. This retrospective study reviewed 131 lesions diagnosed as polythelia in 112 patients from 1999 to 2024. The median age of patients at the time of excision was 28 years (range: 6 months to 72 years). Most (101, 90.2%) patients were female. Lesions were located around the breast (42%), chest (28%), axilla (15%), inframammary fold (8%), and abdomen (6%). Histopathology of 107 lesions showed breast glandular tissue in 83 (77.6%). Sixty (72.3%) of these also exhibited nipple-type smooth muscle, and 24 (22.4%) contained smooth muscle only. Among lesions with glandular tissue, 66/83 (79.5%) had ducts, and 17/83 (20.5%) exhibited lobules. In addition, 54 lesions, initially misdiagnosed as accessory nipples, were reclassified as \"clinical pseudo-polythelia.\" The latter included nevi (48.1%), seborrheic keratosis (13.0%), and hemangiomas (3.7%). Based on our study, polythelia (when encountered in routine practice) is typically a benign and solitary lesion, excised for cosmetic reasons in younger females. Although one lesion of ductal carcinoma <i>in situ</i> in polymastia, under a polythelia, was encountered, no tumor with any nipple or breast lesion was identified in polythelia <i>per se</i>. No other congenital diseases or medical condition was identified in our cohort; however, there were ipsilateral or contralateral malignancies in the native breast in 7.6% of the lesions. Recognition of polythelia is essential to distinguish it from other skin lesions.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1735-1741"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystal-Storing Histiocytosis of the Duodenum in a Patient With IgG-Lambda Multiple Myeloma.","authors":"Shunsuke Koga, Zhaohai Yang, Zahra Alipour","doi":"10.1177/10668969251343639","DOIUrl":"10.1177/10668969251343639","url":null,"abstract":"<p><p>Crystal-storing histiocytosis is a rare condition characterized by the accumulation of crystalline immunoglobulins within histiocytes, often associated with plasma cell disorders such as multiple myeloma. We report a 70-year-old man with a history of IgG-lambda multiple myeloma, systemic amyloidosis, and end-stage renal disease managed with peritoneal dialysis and long-term lanthanum carbonate therapy for hyperphosphatemia, who presented with gastrointestinal bleeding. Endoscopy revealed nodular erythematous mucosa in the duodenum, and biopsies showed histiocytosis in the lamina propria. The histiocytes showed abundant cytoplasm containing periodic acid-Schiff-positive diastase-resistant intracellular material. Immunohistochemical staining revealed diffuse CD68 positivity and lambda light-chain restriction of the storage material in the histiocytes, supporting a diagnosis of crystal-storing histiocytosis. Differential diagnoses, including Whipple disease, mycobacterial infections, lanthanum deposition, amyloidosis, and xanthoma, were excluded based on histological findings and clinical history. This report highlights the importance of recognizing crystal-storing histiocytosis in uncommon sites such as the duodenum, especially in the context of plasma cell dyscrasias.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1846-1851"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whipple Disease Initial Presentation as Supraclavicular Lymphadenopathy in a Patient With Rheumatoid Arthritis: A Diagnostic Challenge.","authors":"Sara E Amin, Swati Gite, Audrey Wanger, Violeta Chavez, Jacob Armstrong, Beenu Thakral, Patricia Navarro, Jennifer Makhoul, Amer Wahed, Navneet Narula, Karan Saluja","doi":"10.1177/10668969251342475","DOIUrl":"10.1177/10668969251342475","url":null,"abstract":"<p><p>Whipple disease is a rare systemic disease caused by <i>Tropheryma whipplei.</i> It can present with a wide range of nonspecific symptoms that might overlap with underlying medical conditions, posing a diagnostic challenge. We present a 61-year-old man with a past medical history of rheumatoid arthritis and chronic inflammatory demyelinating polyneuropathy, who presented with persistent leukocytosis and supraclavicular lymphadenopathy. A positron emission tomography scan revealed hypermetabolic activity in the supraclavicular, abdominal, and pelvic lymph nodes along with a myocardial hypermetabolic lesion, concerning a lymphoproliferative disorder versus sarcoidosis. A supraclavicular lymph node excisional biopsy revealed complete architectural effacement by a diffuse foamy histiocytic infiltrate without granuloma formation or necrosis. The differential diagnosis included underlying infection, histiocytic neoplasm, lymphoproliferative disorder, storage disorder, and others. Immunostains show the histiocytic cells were positive for CD68 and CD163, while negative for S100, CD1a, kappa, lambda, and BRAF V600E. Grocott-Gömöri's methenamine silver and periodic acid-Schiff (PAS) stains demonstrated diffuse intracytoplasmic granular staining that was resistant to diastase treatment. Gram, acid fast bacilli, and Fite stains were negative. Electron microscopy revealed rod-shaped organisms with a trilaminar plasma membrane, morphologically consistent with <i>T whipplei.</i> Polymerase chain reaction was positive for <i>T whipplei</i>, confirming the diagnosis. Although rare, Whipple disease should be considered in immunocompromised patients presenting with nonspecific nongastrointestinal symptoms and lymphadenopathy clinically simulating lymphoma. Periodic acid-Schiff D-positive inclusions, along with confirmatory molecular results, are crucial for diagnosis. Whipple disease is a curable disease that can be lethal if unrecognized, emphasizing the importance of heightened awareness for early diagnosis and timely treatment.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1816-1823"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal Gland Pathology Reporting Among Genitourinary Pathologists: An Orphan Field Handled by Foster Pathologists?","authors":"Ankur R Sangoi, Courtney C Sparger, Sean R Williamson, Justine Barletta, Sambit K Mohanty, Mahmut Akgul","doi":"10.1177/10668969251333436","DOIUrl":"10.1177/10668969251333436","url":null,"abstract":"<p><p>Due to their association with the kidney, adrenal glands are frequently resected by urologists and evaluated by genitourinary (GU) pathologists. However, given the growing complexity of adrenal pathology and advent of a dedicated \"endocrine pathology\" subspecialty, herein we sought to assess the sentiment regarding adrenal pathology among GU pathologists. One hundred twenty-eight pathologists who handle GU specimens participated in a survey including both junior (40% < 10 years in practice) and experienced pathologists (60% > 11 years in practice), who work in academic (75%) or private practice settings (25%). Participants reported \"on the job\" adrenal pathology training (61%) and/or formal training during GU fellowship (36%). While participants felt mainly \"comfortable\" (36%) or \"neutral\" (29%) reporting adrenal specimens, some felt \"uncomfortable\" (15%) or \"very uncomfortable\" (5%). Most reported that adrenal specimens are handled by GU pathology (56%) versus general surgical pathology (26%) or endocrine pathology (22%; although only 30% reported having formal endocrine pathologists). However, when the participants were asked who they felt should be handling adrenal specimens, participants most strongly endorsed either endocrine pathology (74%) or GU pathology (58%). For workplaces that didn't have a dedicated endocrine pathologist, the main limitations were insufficient number of endocrine pathology specimens for the position (53%; 81% reporting an average of ≤10 per month) or insufficient number of qualified endocrine pathologists (46%). Although adrenal specimens are typically received from urology colleagues, many GU pathologists feel it may be prudent to consider them under the rubric of endocrine pathology services as they become more readily available.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1719-1725"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Malignant Transformation of a Biopsy Proven Sporadic Soft Tissue Schwannoma to Spindle Cell MPNST With <i>TP53</i> Mutation as an Early Event.","authors":"Madhurya Ramineni, Veronica Ulici, David G Hicks, Aaron R Huber, Gregory Dieudonne, Xi Wang","doi":"10.1177/10668969251340430","DOIUrl":"10.1177/10668969251340430","url":null,"abstract":"<p><p>Malignant peripheral nerve sheath tumors (MPNSTs) primarily originate from the neurofibromatosis 1 (NF1)- associated and/or sporadic neurofibromas. Reports of malignant transformation from a sporadic soft tissue schwannoma are rare. In most tumors documented in this context so far, the malignant component is an epithelioid MPNST with a strong and diffuse S100 positivity. We present a patient diagnosed with a sporadic soft tissue schwannoma on core biopsy, which underwent rapid malignant transformation to a spindle cell type MPNST. Somatic tumor profiling of the excision specimen revealed <i>NF2</i> loss, <i>TP53</i>, <i>NRAS</i>, and subclonal <i>RICTOR</i> gene mutations. A retrospective immunohistochemical stain for p53 on the core biopsy demonstrated an aberrant staining pattern, indicating an early effect of <i>TP53</i> in the process of malignant transformation.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1807-1815"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Between 70% Ethyl Alcohol and 10% Formalin as Fixative Mediums in Surgical Cooperation Campaigns: A Pilot Study.","authors":"Javier Arredondo Montero, Elena Carracedo Vega, Mónica Bronte Anaut, Paula Ortolá Fortes, Yerani Ruiz de Azúa-Ciria, Adriana Fernández-Ariza, Alejandra Moreno Ibérico, Yessica Paulina Rodriguez-Velandia, Carlos Bardají Pascual, Rosa Guarch Troyas","doi":"10.1177/10668969251335674","DOIUrl":"10.1177/10668969251335674","url":null,"abstract":"<p><p>BackgroundThe lack of adequate resources in international cooperation limits the study of surgical specimens. The literature on inexpensive and widely available fixation media is scarce.Materials and MethodsSpecimens were prospectively collected during a surgical cooperation campaign in Senegal, where a team from Spain provided surgical care to the local population. The lesions were fixed in parallel using 10% formalin and 70% ethyl alcohol. Hematoxylin and eosin (H&E) and immunohistochemical techniques (IHC) were performed. Histological images were independently evaluated by two senior and two junior pathologists through an anonymized questionnaire.ResultsThree surgical specimens were included: 1 lymphoid hyperplasia (3 H&E, 4 IHC), 1 seborrheic keratosis (2 H&E, 5 IHC), and 1 branchial remnant (2 H&E, 2 IHC). Fixation times were similar in all the specimens (10-13 days). All formalin H&E were diagnostic. Ethyl alcohol H&E was 100% diagnostic on 5/7 slides and 75% in the two remaining slides. In most slides, pathologists preferred formalin. Keratin 7, P40, EMA, keratin AE1/AE3, and TTF1 were 100% diagnostic in both groups. CD20, CD45, and EMA were 100% diagnostic in formalin and 75% diagnostic in ethyl alcohol. CD10 was 75% diagnostic in formalin and 25% diagnostic in ethyl alcohol. BCL6 was 75% diagnostic in formalin and 100% diagnostic in ethyl alcohol. IHC preferences were inconsistent.ConclusionsEthyl alcohol shows poorer fixation than formalin but enables diagnosis in most specimens. Immunoreactivity varies by tissue and stain. Further studies are needed to validate these results.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1726-1734"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary Fibrous Tumor of the Seminal Vesicle With Entrapped Benign Glands Mimicking a Mixed Epithelial and Stromal Tumor: A Case Report With Literature Review.","authors":"Anandi Lobo, Gina Dhillon, Marilyn M Bui","doi":"10.1177/10668969251343266","DOIUrl":"10.1177/10668969251343266","url":null,"abstract":"<p><p>Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm known to occur in various soft tissue and visceral locations. Solitary fibrous tumor arising from the seminal vesicles is rare and reported in only 12 earlier patients. Herein, we describe a SFT arising from the left seminal vesicle in a 58-year-old male patient who underwent a robotic left seminal vesiculectomy. Histologically, the tumor resembled a mixed epithelial and stromal tumor due to secondary non-neoplastic proliferation of the benign seminal vesicle tissue admixed with SFT. The spindle cells of SFT had CD34+/STAT6+ immunophenotype, whereas the admixed benign seminal vesicle tissue was negative for both CD34 and STAT6 immunohistochemical stains. Next-generation sequencing confirmed the presence of <i>NAB2::STAT6</i> fusion, thus confirming the diagnosis of SFT. Twenty months after surgery, the patient is on an annual follow-up with no local recurrence or metastasis. For either a biphasic or a spindle cell neoplasm of the seminal vesicles, SFT should be considered in the differential diagnosis.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1837-1845"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late Recurrence of Spindle Cell Sarcoma in Association with <i>TPM3::NTRK1</i> Fusion.","authors":"Xenia Parisi, Anindita Ghosh, Wei-Lien Wang, Nahir Cortes-Santiago, L Jeffrey Medeiros","doi":"10.1177/10668969251343223","DOIUrl":"10.1177/10668969251343223","url":null,"abstract":"<p><p>We report a 31-year-old woman with a history of low-grade, undifferentiated spindle cell sarcoma of the hand diagnosed at 10 years of age and subsequently amputated. The patient remained under surveillance without recurrence for over 20 years before she presented with multiple new masses in the skin of the head and neck. Biopsies confirmed recurrent sarcoma. Imaging studies revealed metastases within the lungs and peri-pancreatic tissue. Molecular analysis of these lesions showed a <i>TPM3::NTRK1</i> fusion, and the patient started treatment on larotrectinib, on which she now remains, relapse and recurrence-free at 40 months. In presenting this patient, we hope to draw attention to the potentially overlooked provisional category of <i>NTRK</i>-rearranged spindle cell neoplasms that has been added to the fifth edition of the World Health Organization (WHO) classifications of pediatric tumors and soft tissue and bone tumors. While these neoplasms constitute only an estimated 1% of pediatric soft tissue neoplasms, discovering <i>NTRK</i> abnormalities in these lesions opens an important line of targeted therapy options, i.e., NTRK inhibitors. We hope to also show the community the potential for <i>NTRK</i>-rearranged spindle cell neoplasms to present with late local recurrence and metastases.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1709-1712"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Amphicrine Carcinoma: A Clinicopathologic Study of Five Patients.","authors":"Hairen Chen, Jinping Chen, Rong Ge","doi":"10.1177/10668969251333111","DOIUrl":"10.1177/10668969251333111","url":null,"abstract":"<p><p><i>Objective.</i> To investigate the clinicopathological features, immunophenotype, diagnosis, differential diagnosis, and prognosis of amphicrine carcinoma (AC), a rare tumor characterized by dual differentiation between adenocarcinoma and neuroendocrine carcinoma. <i>Methods.</i> The clinicopathological data of five patients with AC diagnosed by pathology at Ningbo Clinical Pathology Diagnosis Center between 2020 and 2024 were collected. These specimens were analyzed using light microscopy, special staining, and immunohistochemical staining. Relevant literature was also reviewed. <i>Results.</i> The study included four men and one woman (range: 21-80 years) with gastric (3) and colorectal neoplasms (2). In all patients, tumor cells exhibited infiltrative growth, involving the subserosal or the serosal layer. Three tumors showed diffuse growth, with some cells displaying signet-ring cell features, others showing poorly differentiated neuroendocrine carcinoma changes, and some cells exhibiting plasmacytoid characteristics. In one patient, tumor cells were arranged in nests, with relatively uniform cell sizes and a palisaded pattern at the periphery. Another patient exhibited most tumor cells arranged in glandular structures with minimal mucin in the cytoplasm. Epithelial markers were positive in all patients. All tumor cells tested positive for AB-PAS staining in the cytoplasm. At least one neuroendocrine marker (synaptophysin, chromogranin A, CD56, insulinoma-associated protein 1) was diffusely and strongly positive in each patient. The expression of mismatch repair proteins (MLH1, MSH2, MSH6, PMS2) and RB protein at immunohistochemistry was retained in all samples. <i>Conclusion.</i> Gastrointestinal amphicrine carcinoma is rare and exhibits distinct histological and immunophenotypic features. The combination of histological morphology, immunophenotype, and AB-PAS special staining is crucial for both the diagnosis and differential diagnosis of this tumor.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1713-1718"},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}