International Journal of Surgical Pathology最新文献

{"title":"Rare Palpebral Conjunctival Myxoma With Histopathological and Immunohistochemical Evidence.","authors":"Shirali Gokharu, Obaidur Rehman, Arpan Gandhi, Sima Das","doi":"10.1177/10668969251343831","DOIUrl":"https://doi.org/10.1177/10668969251343831","url":null,"abstract":"<p><p>Conjunctival myxoma is a rare benign tumor which may mimic other common lesions of the conjunctiva. We describe a lesion in a 52-year-old man, initially diagnosed as a conjunctival granuloma, arising from the palpebral conjunctiva. Intraoperatively, anterior orbital extension was noted via a connecting stalk. The lesion was excised completely under local anesthesia. The histopathological analysis and immunohistochemistry confirmed a diagnosis of conjunctival myxoma. Systemic evaluation was normal. At 3-month follow up, the patient remained healthy without any recurrence. Due to life-threatening syndromic associations, histopathological confirmation and systemic evaluation are mandatory when dealing with potential examples of conjunctival myxoma.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969251343831"},"PeriodicalIF":0.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic Breast Cancer to a Dedifferentiated Solitary Fibrous Tumor Arising from a PTEN Hamartoma of Soft Tissue.","authors":"Jingjing Jiao, Dieter Lindskog, William B Laskin, Hao Wu","doi":"10.1177/10668969251343903","DOIUrl":"https://doi.org/10.1177/10668969251343903","url":null,"abstract":"<p><p>Germline mutations or postzygotic mosaicism in <i>PTEN</i> cause PTEN hamartoma tumor syndrome. The hamartomas can occur at the mucocutaneous sites and superficial or deep soft tissue. PTEN hamartomas of soft tissue were initially described in the pediatric population, and therefore, they were considered pediatric lesions. Breast cancer is one of the major diagnostic criteria for Cowden syndrome. We report a 67-year-old female patient with a germline pathogenic variant of <i>PTEN</i> and a remote history of breast cancer who developed metastatic breast carcinoma into a dedifferentiated solitary fibrous tumor (SFT) that arose within a long-standing intramuscular PTEN hamartoma of soft tissue. Clinically, the dedifferentiated SFT was painful and grew rapidly within the hamartoma. Grossly, the fatty hamartoma partially encircled the fleshy dedifferentiated SFT. Upon light microscopy examination, the SFT was largely the conventional type, showing variably cellular bland fibroblasts randomly arranged in fibrous to myxoid background (patternless pattern) with branching thin-walled vessels. Within the conventional SFT, there were minute foci of metastatic ductal carcinoma of the breast, as well as distinct areas of dedifferentiated SFT consisting of mitotically active, hypercellular epithelioid and plump spindle cells with necrosis. In the surrounding fibrofatty tissue, there were increased numbers of vessels, including malformed arteries and veins, and lymphoid follicles, features described in PTEN hamartoma of soft tissue in children. Our report demonstrates that PTEN hamartoma of soft tissue in adult patients can be asymptomatic, detected incidentally, and associated with other neoplasms. Awareness of this rare phenomenon assists in arriving at a correct diagnosis.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969251343903"},"PeriodicalIF":0.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric SMARCA4-Deficient Undifferentiated Carcinoma: A Report of 4 Patients and Literature Review.","authors":"Yuanli Zhong, Jin Liu, Ke Sun, Gangping Wang, Baizhou Li, Yuqing Liu, Nuo Chen, Zhenwei Chen","doi":"10.1177/10668969241291884","DOIUrl":"10.1177/10668969241291884","url":null,"abstract":"<p><p>SMARCA4-deficient undifferentiated carcinoma (SMARCA4-DUC) of the stomach is a rare gastric tumor that has been receiving increased attention in recent years. With its varied pathological presentations, accurate diagnosis can be challenging. In order to improve our understanding of this aggressive neoplasm, we have carefully documented and analyzed 4 patients with gastric SMARCA4-DUC, adding to the overall knowledge of this uncommon malignancy. The patients were all men, with an average age of 69 years (range 57-76 years). The tumors were located in the gastric antrum (2 patients), the gastric body (1 patient), and the cardia (1 patient). Microscopically, the 3 surgical specimens exhibited similar morphological features: large to medium sized tumor cells, round, irregular to epithelioid undifferentiated cells in solid sheets or discohesive nests, with no obvious stromal reaction. In one patient, short spindle cells arranged in reticular, pseudopapillary, and disorderly patterns were observed amidst extensive interstitial edema. Some areas displayed a lymphoma-like starry sky phenomenon. The biopsy specimens showed large cells diffusely distributed in the submucosa, presenting pale pink cytoplasm, fine chromatin, and prominent large red nucleoli resembling melanoma. All 4 patients demonstrated BRG1 (SMARCA4) loss, INI1 (SMARCB1) retention, and focal positivity for epithelial markers (AE1/AE3 or epithelial membrane antigen). Three patients had clinically advanced (stages IIIC-IV) disease. Follow-up revealed that 1 patient deceased within 4.8 months. This article expands the morphological spectrum of this cancer, providing new insights for accurate cancer diagnosis.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"809-819"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Nodular Fasciitis of the Oral Mucosa: Case Report and Review of the Literature.","authors":"Vasily Ovechko, Joshua M Peterson, Hasanain Hasan, Christopher Yi, Roger Throndson, Suimin Qiu","doi":"10.1177/10668969241297258","DOIUrl":"10.1177/10668969241297258","url":null,"abstract":"<p><p>Among all benign and reactive mesenchymal lesions, nodular fasciitis is most frequently misdiagnosed as a sarcoma due to its concerning clinical and histopathological features: it arises on fascial surfaces, grows rapidly, and may infiltrate into adjacent tissues and blood vessels. The most commonly involved sites include upper extremities, trunk, head, and neck, with rare occurrences in the oral cavity. Recurrences following both incomplete and complete excision are rare, and its natural history progresses through self-limited growth followed by spontaneous regression. Herein we present a rapidly growing nodular fasciitis of the buccal mucosa confirmed by molecular testing for <i>USP6</i> gene rearrangements which recurred 3 weeks following complete surgical excision. Additionally, we review reports of oral cavity nodular fasciitis between 2011 and 2023. Increasing awareness and diagnostic accuracy of this benign mimicker of oral cavity malignancy will help prevent unnecessary radical surgical resections.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"992-1000"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Characteristics of Neutrophil-Rich Hepatocellular Carcinoma: An Uncommon Subtype of Primary Liver Cancer.","authors":"Mukul Vij, Lexmi Priya Raju, Dinesh Jothimani, Komalavalli Subbiah, Evangeline Simon, Gowripriya Gowrishankar, Rajesh Rajalingam, Ilankumaran Kaliamoorthy, Ashwin Rammohan, Mohamed Rela","doi":"10.1177/10668969241291882","DOIUrl":"10.1177/10668969241291882","url":null,"abstract":"<p><p><i>Introduction</i>. Neutrophil-rich hepatocellular carcinoma (HCC) is an extremely uncommon subtype of HCC with an overall incidence of <1%. Neutrophil-rich HCC shows poor cellular differentiation and sarcomatoid transformation in most patients. There is prominent neutrophilic inflammatory cell infiltration in the tumor. These tumors are associated with poor prognosis, high rate of recurrence, and metastasis. <i>Methods.</i> Herein, we investigated 4 patients with neutrophil-rich HCC reported at our center. Clinical, radiological, and pathological findings were reviewed. Immunophenotypic characterization of the tumors were done. Granulocyte colony-stimulating factor (G-CSF), programmed cell death ligand 1 (PD-L1), and mismatch repair immunostains were performed in all 4 tumors. <i>Results.</i> We report 4 neutrophil-rich HCCs in 3 male patients and one female patient with an age range of 43 to 64 years. Three underwent living donor liver transplantation and one underwent right hepatectomy. Tumor measured 0.5 cm to 12 cm in maximum dimension. Histologically, tumors demonstrated moderate to marked cellular pleomorphism. Spindle cell transformation was noted in 3 tumors. Three tumors showed vascular invasion, and one tumor showed bile duct invasion. Immunopositivity for Hep Par-1, arginase-1, and glypican-3 was present in all tumors. Tumors also expressed stemness markers including KRT19 and EpCAM. Cytoplasmic positivity for G-CSF and immunoexpression of PD-L1 was demonstrated. We also report proficient mismatch repair by immunohistochemistry in all tumors. <i>Conclusion.</i> Neutrophil-rich HCC is an aggressive primary liver cancer which demonstrates stemness-related features. Programmed cell death ligand 1 expression in tumor cells suggests distinct immunogenic features and potential role of anti-PD-L1 therapies in inoperable disease.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"828-841"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-Induced Intraosseous Malignant Peripheral Nerve Sheath Tumor: A Case Report.","authors":"Celeste E Wagner, Rasha Alfattal, Jayati Mallick","doi":"10.1177/10668969241286061","DOIUrl":"10.1177/10668969241286061","url":null,"abstract":"<p><p>IntroductionThe significance of radiation therapy in cancer treatment comes with associated complications, including fibrosis, osteonecrosis, and the development of secondary malignancies, such as malignant peripheral nerve sheath tumors (MPNSTs). We emphasize the importance of understanding these complications for an effective patient management.MethodsWe report a 47-year-old man with a history of squamous cell carcinoma of the tongue, treated with surgery, chemotherapy, and radiation therapy. The patient later presented with symptoms that led to the discovery of an intraosseous MPNST.ResultsHistopathological examination revealed characteristic features of MPNST, including spindle cells arranged is sweeping fascicles with contrasting hypercellular and hypocellular areas, producing a marble-like pattern, with atypical wavy, buckled, hyperchromatic nuclei, and brisk mitotic activity. Immunohistochemical analysis showed patchy positive staining for S100 and SOX10, and a complete loss of H3K27me3 expression. This report underscores the challenge of diagnosing secondary malignancies post-radiation therapy and the importance of careful histological examination to differentiate them from other conditions.ConclusionsIn conclusion, radiation-induced secondary malignancies are a significant late side effect of radiation therapy that can profoundly impact treatment decision-making and requires a high index of suspicion during post radiation surveillance. Malignant peripheral nerve sheath tumor serves as a pertinent example, highlighting the importance of considering long-term risks when developing optimal management plans for cancer patients.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"916-920"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Tumor Proliferation Markers in Early-Stage Luminal Breast Cancer: A Comprehensive Study Using Mitotic Activity Index, Ki-67, and Phosphohistone H3 Expression.","authors":"P Jamshiya, Soundarya Ravi, Srinivas Bheemanathi Hanuman, Sree Rekha Jinkala, Ankit Jain, Prasanth Penumadu","doi":"10.1177/10668969241295355","DOIUrl":"10.1177/10668969241295355","url":null,"abstract":"<p><p><i>Introduction and Aim:</i> Routinely used proliferation markers such as mitotic activity index (MAI) and Ki-67 index show limited reproducibility due to high interobserver variability in breast cancer assessment. Phosphohistone H3 (PhH3), a novel proliferation marker, is gaining attention in breast cancer research. This study aimed to evaluate the inter-rater agreement among MAI, Ki-67, and PhH3 expressions in early-stage luminal breast cancer and assess the impact of replacing MAI with PhH3 index on tumor histological grading. <i>Materials and Methods:</i> Three pathologists assessed MAI, Ki-67, and PhH3 expressions in 66 early-stage luminal breast cancer specimens. Mitotic Activity Index was scored based on mitotic figures in an area of 2 mm² while Ki-67 index utilized a 14% threshold for positively stained nuclei. Phosphohistone H3 expression cutoff was set at 13 positive cells per 2 mm². The inter-rater agreement for the 3 variables was analyzed using Cohen kappa statistics. <i>Results:</i> Among the 3 parameters, the kappa score of the PhH3 expression reflected very strong agreement between the 3 observers (κ = 0.991, 0.907, and 0.916). Only moderate agreement was noted for MAI (κ = 0.898, 0.562, and 0.592) and substantial agreement for Ki-67 index (κ = 0.869, 0.673, and 0.678). Moreover, replacing MAI with PhH3 index led to upgrade of histological grade in 15% to 16% of patients. <i>Conclusion:</i> Our study demonstrated that PhH3 is a more reproducible proliferation marker than MAI and Ki-67. Incorporation of PhH3-based mitotic index in breast cancer grading might reduce the variation in the assessment of histological grade.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"882-890"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perianal Paget Disease With an Enteric Phenotype and Associated In-Situ/Dysplastic Glandular Component: Report of a Potentially Novel Entity and Review of the Literature.","authors":"Dana Pea, Naziheh Assarzadegan, Krista Terracina, David Saulino","doi":"10.1177/10668969241297261","DOIUrl":"10.1177/10668969241297261","url":null,"abstract":"<p><p>Extramammary Paget disease is an uncommon cutaneous malignancy that primarily affects areas rich in apocrine glands. Here, we aim to present an 84-year-old woman with a distinctive perianal neoplastic process comprised of conventional Paget disease with an intertwined in-situ glandular component. Rare foci of glands embedded in pools of mucin were also identified in the most recent excision, consistent with mucinous adenocarcinoma. Immunohistochemical staining demonstrated an enteric phenotype of the tumor cells, with expression of keratin 20, caudal type homeobox transcription factor 2 (CDX2), and special AT-rich sequence binding protein 2 (SATB2) (patchy, weak); keratin 7 and BerEP4 staining were also noted. Molecular analysis via next generation sequencing revealed pathogenic variants in <i>ERBB2</i>, <i>TP53</i>, and <i>SF3B1.</i> Given the unique histomorphology and immunohistochemical staining pattern, suspicion for a colorectal primary tumor was high, however; extensive workup including imaging, testing for tumor markers, and colonoscopic evaluation has not identified any other lesion thus far. Multiple biopsies and excisions in the area demonstrated recurrent disease over a 4-year span; with no evidence of deep invasion or metastasis. This tumor appears to be exceptional among reports in the literature given its extensive in-situ glandular component; and we are not aware of any documented <i>SF3B1</i> mutation to date. Disease recurrence in this patient highlights the need for clinical vigilance. Defining the molecular profile in these lesions can also be useful, particularly when assessing potential treatment options for advanced disease.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1045-1053"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Clinicopathological Features of Autoimmune Metaplastic Atrophic Gastritis in the Eastern Province of Saudi Arabia: A Regional Study.","authors":"Zainab I Alruwaii, Anwar Alsayed, Jafar Albagashi, Julio Poveda, Wael Al Suliman, Khaleel I Al-Obaidy, Mahdi Aljaroudi, Elizabeth Montgomery","doi":"10.1177/10668969241295348","DOIUrl":"10.1177/10668969241295348","url":null,"abstract":"<p><p><i>Introduction.</i> Autoimmune metaplastic atrophic gastritis (AMAG, also termed autoimmune gastritis) is a chronic gastritis of autoimmune pathogenesis. Although its clinical and pathological features are well-documented in many countries, data from Middle Eastern populations remain scarce. This study examined the prevalence of AMAG in gastric specimens from the region, specifically from Saudi Arabia. <i>Methods.</i> We conducted a retrospective review of the pathology database of gastric specimens with a diagnosis of AMAG between 2020 and 2023. Detailed clinical, endoscopic, and pathological features of identified features were described. <i>Result.</i> Of the 978 gastric biopsies received, 17 patients were diagnosed with AMAG. The cohort comprised 11 women (64.7%) and 6 men (35.3%), presenting at a median age of 50 years (range: 32-85). Clinical manifestations varied widely, from abdominal pain (n = 6), dyspepsia (n = 2), symptomatic anemia with significant vitamin B12 deficiency (2 of 17) to asymptomatic/incidentally diagnosed patients (5 of 17). The tissue samples showed varying histological characteristics, with some showing lymphoplasmacytic infiltrate, mucosal atrophy, and hyperplasia of enterochromaffin-like cells. <i>Conclusion.</i> The observed prevalence of AMAG in our study aligns with global averages reported for other populations. The diverse clinical presentations highlight the need for awareness of findings in AMAG in gastric biopsies to ensure appropriate clinical management.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"871-876"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Distinct Visual Scan Paths for Pathologists in Rare-Element Search Tasks.","authors":"Alana Lopes, Sean Rasmussen, Ryan Au, Vignesh Chakravarthy, Tricia Chinnery, Jaryd Christie, Bojana Djordjevic, Jose A Gomez, Natalie Grindrod, Robert Policelli, Anurag Sharma, Christopher Tran, Joanna C Walsh, Bret Wehrli, Aaron D Ward, Matthew J Cecchini","doi":"10.1177/10668969241294239","DOIUrl":"10.1177/10668969241294239","url":null,"abstract":"<p><p>BackgroundThe search for rare elements, like mitotic figures, is crucial in pathology. Combining digital pathology with eye-tracking technology allows for the detailed study of how pathologists complete these important tasks.ObjectivesTo determine if pathologists have distinct search characteristics in domain- and nondomain-specific tasks.DesignSix pathologists and six graduate students were recruited as observers. Each observer was given five digital \"Where's Waldo?\" puzzles and asked to search for the Waldo character as a nondomain-specific task. Each pathologist was then given five images of a breast digital pathology slide to search for a single mitotic figure as a domain-specific task. The observers' eye gaze data were collected.ResultsPathologists' median fixation duration was 244 ms, compared to 300 ms for nonpathologists searching for Waldo (<i>P </i>< .001), and compared to 233 ms for pathologists searching for mitotic figures (<i>P </i>= .003). Pathologists' median fixation and saccade rates were 3.17/second and 2.77/second, respectively, compared to 2.61/second and 2.47/second for nonpathologists searching for Waldo (<i>P </i>< .001), and compared to 3.34/second and 3.09/second for pathologists searching for mitotic figures (<i>P </i>= .222 and <i>P </i>= .187, respectively). There was no significant difference between the two cohorts in their accuracy in identifying the target of their search.ConclusionsWhen searching for rare elements during a nondomain-specific search task, pathologists' search characteristics were fundamentally different compared to nonpathologists, indicating pathologists can rapidly classify the objects of their fixations without compromising accuracy. Further, pathologists' search characteristics were fundamentally different between a domain-specific and nondomain-specific rare-element search task.</p>","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"861-870"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}