International Journal of Surgical Pathology最新文献_第9页

Angioleiomyoma, Venous Type of the Sinonasal Tract: Emerging as a Distinct Entity in the WHO Classification, Mandating Pathological Expertise in the Absence of Clear Clinical and Radiologic Features. 鼻窦静脉型血管瘤：在世界卫生组织的分类中逐渐成为一个独特的实体，在没有明确临床和放射学特征的情况下需要病理专家的诊断。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-02-01 Epub Date: 2024-05-23 DOI: 10.1177/10668969241256114

Nada Shaker, Poonam Vohra, Swikrity U Baskota, Nuha Shaker, Omar P Sangueza, Dinesh Pradhan

引用次数: 0

Synchronous Low-Grade Central Osteosarcoma and Ewing Sarcoma: A Rare Case Report. 同步低级别中央骨肉瘤和尤文肉瘤：罕见病例报告

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-02-01 Epub Date: 2024-03-20 DOI: 10.1177/10668969241239675

Daniel Christensen, Jeffrey A Belair, Atrayee BasuMallick, Scot A Brown, Michael Klein, Wei Jiang

{"title":"Synchronous Low-Grade Central Osteosarcoma and Ewing Sarcoma: A Rare Case Report.","authors":"Daniel Christensen, Jeffrey A Belair, Atrayee BasuMallick, Scot A Brown, Michael Klein, Wei Jiang","doi":"10.1177/10668969241239675","DOIUrl":"10.1177/10668969241239675","url":null,"abstract":"A 23-year-old female patient presented with radicular back pain, perineal numbness, and urinary retention. The patient was diagnosed with cauda equina syndrome and magnetic resonance imaging (MRI) of the spine revealed an enhancing osseous lumbar lesion causing severe central stenosis. A core needle biopsy of the lumbar spine showed microscopic features compatible with a small round blue cell tumor. CD99 and FLI1 were positive in the tumor cells. Next-generation sequencing demonstrated a EWSR1::FLI1 fusion. Given these findings, the spine lesion was diagnosed as Ewing sarcoma. The patient underwent surgical decompression of L2. On further workup, an MRI revealed an ill-defined enhancing mass of the right distal femur. This area was biopsied, demonstrating a fibro-osseous lesion with osteoblast proliferation containing nuclear atypia, low mitotic activity, and SATB2 positivity, diagnosed as low-grade central osteosarcoma (LGCOS). The patient underwent resection, which showed a classic LGCOS by histomorphology. Although fluorescence in-situ hybridization study for MDM2 gene amplification was negative, the overall findings are most consistent with LGCOS. These neoplasms are considered to be synchronous due to the presentation of each entity within 6 months. Considering the aggregate yearly incidence of Ewing sarcoma (approximately 1 case per 750 000 per year) and LGCOS (approximately 1 case per 10 million per year), the aggregate yearly probability of developing both of these genetically unrelated tumors in a single individual is 1 per 7.5 trillion per year, and it is likely such an event has never happened in the past.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"131-137"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What's in a Name? Replacing Pejorative Terminology in Anatomic Pathology. 名字里有什么？取代解剖病理学中的贬义术语。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-02-01 Epub Date: 2024-03-21 DOI: 10.1177/10668969241236700

Michael Magguilli, Cody Thomas, Evan Fowle

引用次数: 0

Rectifying Controversial Medical Eponyms: Cleansing the Lexicon. 纠正有争议的医学地名：清理词典。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-02-01 Epub Date: 2024-08-02 DOI: 10.1177/10668969241265042

Steven H Yale, Halil Tekiner, Eileen S Yale

引用次数: 0

A Rare Case Report of Intraosseous Spindle and Epithelioid Rhabdomyosarcoma With TFCP2 Rearrangement: A Pathological Diagnostic Conundrum and Literature Review. 骨内纺锤形和上皮样横纹肌肉瘤伴 TFCP2 重排的罕见病例报告：病理诊断难题与文献综述。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-02-01 Epub Date: 2024-03-18 DOI: 10.1177/10668969241239676

Cheng Si, Yihuan Wang, Jinghua Zhu

{"title":"A Rare Case Report of Intraosseous Spindle and Epithelioid Rhabdomyosarcoma With TFCP2 Rearrangement: A Pathological Diagnostic Conundrum and Literature Review.","authors":"Cheng Si, Yihuan Wang, Jinghua Zhu","doi":"10.1177/10668969241239676","DOIUrl":"10.1177/10668969241239676","url":null,"abstract":"Rhabdomyosarcoma is a highly malignant tumor with striated muscle differentiation, which is histologically classified as alveolar, embryonal, pleomorphic, and spindle cell/sclerosing histological subtype. Rhabdomyosarcoma with TFCP2 rearrangement, which usually occurs in the bone, is a newly identified rare spindle and epithelioid rhabdomyosarcoma with characteristic clinicopathological features and molecular alterations. We report a 39-year-old female patient who underwent local excision of the mandibular lesion. Microscopically, the intraosseous tumor was composed of spindle-shaped, epithelioid, and rhabdomyoblastic cells with atypical nuclei and atypical mitotic figures. In addition, TFCP2 rearrangement was revealed by the fluorescence in situ hybridization. The tumor was thus correctly diagnosed as rhabdomyosarcoma with TFCP2 rearrangement. The patient was scheduled to undergo radiotherapy, and triple-agent chemotherapy after surgery, and no tumor recurrence or metastasis was detected during the 3-month postoperative follow up. Since this tumor is relatively rare and newly recognized, it can be easily misdiagnosed or missed and might be a conundrum of pathological diagnosis. Familiarity with its clinicopathological features and molecular alterations is essential for its correct diagnosis. Therefore, we summarized the clinicopathological, immunohistochemical, and molecular alterations of 43 cases of this rare rhabdomyosarcoma variant in the English-language literature. In addition, the differential diagnosis of this lesion is crucial either.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"125-130"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Langerhans Cell Histiocytosis Post-Hodgkin Lymphoma Completely Resolved With Vinblastine in a Heavy Smoker: Coincidence or Causation? 一名重度吸烟者的肺朗格汉斯细胞组织细胞增生症后霍奇金淋巴瘤在使用长春新碱后完全缓解：巧合还是因果关系？

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-02-01 Epub Date: 2024-05-20 DOI: 10.1177/10668969241253216

Nada Shaker, Nuha Shaker, Rafat Abu Shakra, Leonard Yenwongafi, Dinesh Pradhan, Omar P Sangueza

{"title":"Pulmonary Langerhans Cell Histiocytosis Post-Hodgkin Lymphoma Completely Resolved With Vinblastine in a Heavy Smoker: Coincidence or Causation?","authors":"Nada Shaker, Nuha Shaker, Rafat Abu Shakra, Leonard Yenwongafi, Dinesh Pradhan, Omar P Sangueza","doi":"10.1177/10668969241253216","DOIUrl":"10.1177/10668969241253216","url":null,"abstract":"The association among Langerhans cell histiocytosis, hematolymphoid malignancies, and heavy smoking has been addressed in medical literature to identify a possible potential link. Such occurrence can pose diagnostic challenges, as well as important clinical implications for disease progression and treatment approaches. We present pulmonary Langerhans cell histiocytosis instance in a 35-year-old male patient, with a 34-pack-year smoking history and nodular sclerosing Hodgkin lymphoma stage IIB who developed multiple bilateral lung nodules. The patient completed 6 cycles of doxorubicin (Adriamycin), bleomycin, vinblastine, and dacarbazine chemotherapy and radiotherapy 2 years earlier. CT chest scans revealed numerous micronodules scattered randomly throughout the upper and lower left lung lobes. Subsequent wedge resection exhibited cellular proliferation with grooved nuclei, eosinophilic cytoplasm, and surrounding inflammatory components. Immunohistochemical staining showed positive staining for S100 and CD1a confirming a diagnosis of pulmonary Langerhans cell histiocytosis. The patient responded to a 6-week treatment with vinblastine and prednisolone. A subsequent CT scan of the lungs revealed complete resolution after 3 years. This report underscores the importance of identifying pulmonary Langerhans cell histiocytosis in heavy smokers with Hodgkin lymphoma presenting with multiple nodular pulmonary lesions. For patients with Hodgkin lymphoma and a possible genetic predisposition, smoking may contribute to the overt development of pulmonary Langerhans cell histiocytosis. Therefore, smoking cessation and careful follow-up examinations are required. Further research is recommended to elucidate the underlying mechanisms of this intriguing association.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"209-213"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bronchial Basaloid Papillary Tumor of Uncertain Malignant Potential: A Case Report. 恶性可能性不确定的支气管基底乳头状瘤：病例报告

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-02-01 Epub Date: 2024-06-12 DOI: 10.1177/10668969241256104

Ling Nie, Biao Zhang, Min Li, Wenyan Guan, Fanqing Meng

{"title":"Bronchial Basaloid Papillary Tumor of Uncertain Malignant Potential: A Case Report.","authors":"Ling Nie, Biao Zhang, Min Li, Wenyan Guan, Fanqing Meng","doi":"10.1177/10668969241256104","DOIUrl":"10.1177/10668969241256104","url":null,"abstract":"Bronchial papillomas are benign tumors, which can be divided into different subtypes based on the cellular features. So far, no bronchial papilloma with basaloid cell features has been reported. We report a bronchial basaloid papillary tumor in a 67-year-old woman. Tumor recurrence and malignant transformation were observed after a long-term follow-up. The clinical, histological, immunohistochemical, and genetic features were reappraised. The primary tumor was characterized by papillary growth pattern and basaloid neoplastic cells, only a small amount of neoplastic cells showed mature characteristics. The tumor originated from respiratory epithelium and had a low proliferation index by Ki-67. Keratin (KRT) 5/6 and KRT7 showed patchy or partial positivity. Myoepithelial markers were negative. P63 was diffusely positive, but it was negative in the small amount of tumor cells with mature characteristics. The common genetic alterations (EGFR, KRAS, BRAF V600E, HER2, and ALK) of lung cancers were not detected. However, tumor recurrence was observed in the mediastinum and esophagus 12 years after surgery. The recurrent tumor had a morphology overlapping with that of the primary tumor; however, it displayed significantly malignant characteristics. The recurrent tumor was not related to high-risk HPV. A high variant allele frequency was observed in tumor suppressor gene BRCA1, TP53, oncogene GNA11, and KIT, which were all missense mutations. Considering the bland features of the primary tumor and the fact of tumor recurrence and undisputed malignant transformation, the basaloid papillary tumor was considered a tumor with uncertain malignant potential.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"229-235"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenoid Cystic Carcinoma of the Lacrimal Glands: A Single Institute Experience. 泪腺腺样囊性癌：单一研究所的经验。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-02-01 Epub Date: 2024-06-05 DOI: 10.1177/10668969241256110

Pratik Q Deb, Neena Mirani

引用次数: 0

Gastric Type Endocervical Adenocarcinoma With Concurrent High-Grade Squamous Intraepithelial Lesion: A Clinicopathologic Study of Three Patients. 胃型宫颈内膜腺癌并发高级别鳞状上皮病变：三例患者的临床病理学研究。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-02-01 Epub Date: 2024-04-01 DOI: 10.1177/10668969241241637

Yao Sun, Wanrun Lin, Qiuqin Zou, Wenxin Zheng, Huijuan Zhang, Feng Zhou

{"title":"Gastric Type Endocervical Adenocarcinoma With Concurrent High-Grade Squamous Intraepithelial Lesion: A Clinicopathologic Study of Three Patients.","authors":"Yao Sun, Wanrun Lin, Qiuqin Zou, Wenxin Zheng, Huijuan Zhang, Feng Zhou","doi":"10.1177/10668969241241637","DOIUrl":"10.1177/10668969241241637","url":null,"abstract":"Objective: We investigate gastric-type endocervical adenocarcinoma (ECA), a prominent HPV-independent adenocarcinoma, and its coexistence with high-grade squamous intraepithelial lesion (HSIL) through the examination of three such tumors.Methods: In this study, we conducted an in-depth review of three patients with gastric-type ECA, each associated with high-risk HPV infection as detected on Pap smears. We detailed the clinical and pathological features of each patient and utilized RNAscope for high-risk HPV testing to ascertain HPV status in both gastric-type ECA and HSIL components. Immunohistochemistry with p16, p53, and other biomarkers was also applied.Results: The gastric-type ECA component, characterized by well-differentiated glands with abundant, clear to eosinophilic cytoplasm, distinct cellular borders, and pale nuclei with conspicuous nucleoli, tested negative for both p16 and high-risk HPV, unlike the concurrent HSIL components which were positive. Additionally, two tumors showed aberrant p53 protein expression in the gastric-type ECA areas, and elevated carbohydrate antigen19-9 levels were noted in two patients. Treatment consisted of total abdominal hysterectomy and bilateral salpingo-oophorectomy, supplemented by chemotherapy and/or radiation, with disease-free intervals of 24, 12, and 40 months post-treatment, respectively.Conclusion: This study highlights the critical need for meticulous diagnostic protocols that combine morphological examination, immunohistochemistry, and HPV RNA in situ hybridization. The rarity of gastric-type ECA coexisting with HPV infection underscores the necessity for continuous research and vigilant monitoring in the field of gynecological oncology.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"13-18"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fenofibrate in Lipoprotein Glomerulopathy: A 20-Year Long Resolution. 非诺贝特治疗脂蛋白肾小球病：长达 20 年的研究

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-02-01 Epub Date: 2024-11-12 DOI: 10.1177/10668969241297262

Francesco Sbrana, Beatrice Dal Pino

引用次数: 0