International Journal of Surgical Pathology最新文献_第2页

Heterotopic Ossification with Intrathyroidal Extramedullary Hematopoiesis in Multifocal Papillary Thyroid Carcinoma: Histopathological Findings and Literature Review. 多灶性甲状腺乳头状癌中的异位骨化与甲状腺内髓外造血：组织病理学发现与文献综述

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-06-01 Epub Date: 2024-11-12 DOI: 10.1177/10668969241291886

Tamara Díaz Vico, Irene Grao Torrente, María Ángeles Martínez Izquierdo, Alejandro García Muñoz-Nájar, Camilo José Castellón Pavón, Manuel Durán Poveda

{"title":"Heterotopic Ossification with Intrathyroidal Extramedullary Hematopoiesis in Multifocal Papillary Thyroid Carcinoma: Histopathological Findings and Literature Review.","authors":"Tamara Díaz Vico, Irene Grao Torrente, María Ángeles Martínez Izquierdo, Alejandro García Muñoz-Nájar, Camilo José Castellón Pavón, Manuel Durán Poveda","doi":"10.1177/10668969241291886","DOIUrl":"10.1177/10668969241291886","url":null,"abstract":"In recent decades, there has been an increase in the identification of thyroid nodules, both benign and malignant, due to the rise in imaging studies and complementary tests. Among thyroid gland tumors, papillary thyroid carcinoma (PTC) stands out as the most prevalent. Degenerative changes, mainly in the form of nodular goiter, have been recorded, occasionally including areas of calcification and, more rarely, ossification; although the latter seldom progresses to calcinosis. Ectopic bone formation, known as osseous metaplasia, is a rare phenomenon in the thyroid gland, even more so when associated with extramedullary hematopoiesis (EMH), characterized by the presence of hematopoietic elements outside the bone marrow. We present the first documented instance in our country of a patient diagnosed with malignant thyroid nodule, specifically PTC, exhibiting areas of heterotopic ossification with EMH on histopathological examination of the surgical specimen. A possible relationship between heterotopic ossification, EMH, and PTC is suggested. Various growth factors such as bone morphogenetic proteins (BMPs), specific BMP subtypes, and associated receptors could play a crucial role in initiating and developing ectopic bone formation in the context of PTC. However, further research is needed to fully elucidate its clinical significance and impact on the therapeutic management of these patients.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"970-975"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Warthin-like Papillary Thyroid Carcinoma: A Case Report and Review of the Literature. 疣状甲状腺乳头状癌：病例报告和文献综述。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-06-01 Epub Date: 2024-11-12 DOI: 10.1177/10668969241291895

J N Aparnna, Pavithra Ayyanar, Mukund N Sable, Dillip Kumar Samal, Amit Kumar Adhya, Pritinanda Mishra

{"title":"Warthin-like Papillary Thyroid Carcinoma: A Case Report and Review of the Literature.","authors":"J N Aparnna, Pavithra Ayyanar, Mukund N Sable, Dillip Kumar Samal, Amit Kumar Adhya, Pritinanda Mishra","doi":"10.1177/10668969241291895","DOIUrl":"10.1177/10668969241291895","url":null,"abstract":"Warthin-like subtype of papillary thyroid carcinoma (WLPTC) is a rare subtype of papillary thyroid carcinoma. This PTC subtype shows some pattern resemblance to Warthin tumors of the salivary gland, which confers its name but is a not genetically similar to salivary Warthin tumor, with the most frequent genetic change in WLPTC being BRAF p.V600E, the most frequent genetic driver of PTC. Warthin-like subtype of papillary thyroid carcinoma is found to have a favorable prognosis. We report a 44-year-old woman who presented with anterior neck swelling and elevated levels of antithyroid peroxidase antibodies. Fine-needle aspiration cytology showed features of papillary thyroid carcinoma and lymphocytic thyroiditis. On histopathological examination, thyroid follicular cells have oncocytic cytoplasm with infiltration of the tumor and fibrovascular cores by a dense lymphoplasmacytic infiltrate. Numerous multinucleated giant cells in the tumor are a notable feature. The final diagnosis is Warthin-like papillary thyroid carcinoma arising in association with chronic lymphocytic (Hashimoto) thyroiditis. Along with this case report, we perform a literature review of WLPTC between 2010 and 2024.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"956-963"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcoid-like Reaction in a Patient With Colon Cancer: A Case Report and Mini-Review. 结肠癌患者的肉样瘤样反应：病例报告与微型综述。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-06-01 Epub Date: 2024-11-20 DOI: 10.1177/10668969241291893

Chiaki Ikeshita, Eri Hotta, Satoshi Mochizuki, Koji Miyagawa, Nobuaki Fuji, Eiichi Konishi

{"title":"Sarcoid-like Reaction in a Patient With Colon Cancer: A Case Report and Mini-Review.","authors":"Chiaki Ikeshita, Eri Hotta, Satoshi Mochizuki, Koji Miyagawa, Nobuaki Fuji, Eiichi Konishi","doi":"10.1177/10668969241291893","DOIUrl":"10.1177/10668969241291893","url":null,"abstract":"Sarcoidosis is a multisystemic and chronic inflammatory disorder characterized by the manifestation of epithelioid cell granulomas in various organs. Sarcoid-like reactions occur in patients who do not fulfill the diagnostic criteria for sarcoidosis but present with similar clinical and histological features. An 80-year-old man presented to our hospital with several subcutaneous nodules on the extremities. Based on clinical and pathological findings, the subcutaneous nodules were diagnosed as sarcoid nodules. However, the patient did not meet the diagnostic criteria for sarcoidosis. Positron emission tomography-computed tomography revealed abnormalities in several uptakes in the extremities that matched with the subcutaneous nodules and transverse colon. Additional examinations using lower gastrointestinal endoscopy, pathological examination, and contrast-enhanced computed tomography revealed tubular adenocarcinoma of the transverse colon. The patient underwent partial colon resection and lymph node dissection. The sarcoid nodules disappeared within 2 months postoperatively. Approximately 2 years later, there were no signs of recurrence of subcutaneous nodules, colon cancer, or additional findings suggestive of sarcoidosis. To our knowledge, this is the first report on a sarcoid-like reaction developing in the subcutaneous tissues of the extremities, associated with colon cancer, wherein the sarcoid nodules disappeared after the operation.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1001-1009"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Papillomavirus (HPV) Genotypes in Mixed Squamous Cell Carcinoma of the Penis: A Study of 101 Tumors. 阴茎混合鳞状细胞癌中的人类乳头状瘤病毒 (HPV) 基因型：101 个肿瘤的研究。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-06-01 Epub Date: 2024-11-13 DOI: 10.1177/10668969241295352

María José Fernández-Nestosa, Diego F Sanchez, Sofia Cañete-Portillo, Laia Alemany, Omar Clavero, Belén Lloveras, Ingrid Rodriguez, Antonella Lobatti, Cesar Urizar, Nubia Munoz, Wim Quint, Silvia de Sanjosé, Francisco X Bosch, Antonio L Cubilla

{"title":"Human Papillomavirus (HPV) Genotypes in Mixed Squamous Cell Carcinoma of the Penis: A Study of 101 Tumors.","authors":"María José Fernández-Nestosa, Diego F Sanchez, Sofia Cañete-Portillo, Laia Alemany, Omar Clavero, Belén Lloveras, Ingrid Rodriguez, Antonella Lobatti, Cesar Urizar, Nubia Munoz, Wim Quint, Silvia de Sanjosé, Francisco X Bosch, Antonio L Cubilla","doi":"10.1177/10668969241295352","DOIUrl":"10.1177/10668969241295352","url":null,"abstract":"Squamous cell carcinomas with two or more coexisting clearly different histological subtypes of penile carcinomas are designated as mixed carcinomas in current classification models. They represent about 10% of all penile carcinomas. The aim of this study was to detect HPV genotypes in these unusual tumors. Tumors were selected from an international series of 1010 patients with penile carcinomas. Mixed carcinomas were grouped, according to WHO recommendations, as follows: 1. Carcinomas with warty/basaloid features mixed with HPV-independent carcinomas and 2. HPV-independent subtypes mixed with each other. HPV detection and p16INK4a immunostaining were performed. For HPV detection, whole tissue section-PCR analyses were performed by SPF10-DEIA-LiPA25 (version 1). As expected, HPV was detected more frequently in HPV-associated mixed carcinomas than in HPV-independent mixed carcinomas. Carcinomas with basaloid or warty features mixed with other SCC subtypes showed an HPV positivity rate of 46% (33 of 72 tumors) compared with 7% found in tumors with nonwarty/basaloid morphology (2 of 29 tumors). Eleven high-risk HPV genotypes were identified and the most common was HPV16 (65%) usually associated with basaloid morphology. p16INK4a immunostaining was positive in 76% of HPV-positive tumors. As in nonmixed carcinomas, although in lower proportion, a variable array of HPV genotypes was detected in mixed carcinomas. Apparently, the presence of a non-HPV component in an otherwise typical HPV-associated type tumor does adversely affect the prevalence of HPV positivity. Any amount of HPV-associated morphology superior to 20% in a mixed tumor is sufficient to classify them as HPV-associated, a WHO requirement.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"877-881"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PRAME-Negative Rectal Mucosal Blue Nevus. PRAME 阴性直肠粘膜蓝色痣。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-06-01 Epub Date: 2024-11-12 DOI: 10.1177/10668969241291894

Madelyn M Class, Atef Labeeb, Lisa Zhai, Farhaan Hafeez

引用次数: 0

Atypical Spindle Cell/Pleomorphic Lipomatous Tumor With Hibernoma-Like Morphology: Expanding the Morphological Spectrum. 具有蜂巢瘤样形态的非典型纺锤形细胞/多形性脂肪瘤：扩展形态学范围。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-06-01 Epub Date: 2024-11-12 DOI: 10.1177/10668969241291881

Fleur Cordier, David Creytens

引用次数: 0

Endocervical Adenocarcinoma With Micropapillary Component, a Distinct Histological Subtype Associated With Aggressive Behavior and Poor Prognosis: A Clinicopathologic Study of 10 Patients. 带有微乳头状成分的宫颈内膜腺癌是一种与侵袭性和预后不良相关的独特组织学亚型：10 例患者的临床病理学研究。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-06-01 Epub Date: 2024-11-13 DOI: 10.1177/10668969241291878

Su Wang, Xianfeng Huang, Xin Zhou, Lili Chen, Huijuan Zhang, Hao Chen, Feng Zhou

{"title":"Endocervical Adenocarcinoma With Micropapillary Component, a Distinct Histological Subtype Associated With Aggressive Behavior and Poor Prognosis: A Clinicopathologic Study of 10 Patients.","authors":"Su Wang, Xianfeng Huang, Xin Zhou, Lili Chen, Huijuan Zhang, Hao Chen, Feng Zhou","doi":"10.1177/10668969241291878","DOIUrl":"10.1177/10668969241291878","url":null,"abstract":"Objective. Endocervical adenocarcinoma (ECA) with a micropapillary component is considered to be associated with aggressive behavior and poor prognosis. So far, only limited studies investigated this histological subtype of ECA in the literature. In this study, we present a clinicopathological analysis of 10 such tumors. Methods. We retrieved ten ECAs with a micropapillary component between January 2014 and July 2023 and analyzed their clinicopathologic features. Results. At diagnosis, nine tumors (90%) were of advanced clinical stage (FIGO stage ≥ IIA), nine tumors (90%) exhibited deep stromal invasion (≥2/3 of the cervix), and three tumors (30%) showed parametrial involvement. Lymphovascular invasion was evident in all tumors (100%), and lymph node metastasis was found in eight tumors (80%). Among the 10 patients, six were alive without disease (60%), one had a recurrent/later metastatic tumor (10%), and three died from the disease (30%). Furthermore, eight tumors were positive for PD-L1 expression (80%), while only one tumor showed HER2 overexpression (10%), and one tumor exhibited p53 mutant-type staining (10%). Conclusion. Endocervical adenocarcinomas with micropapillary components are associated with aggressive clinical behavior and a poor prognosis, which can be found in various conventional histological types of ECAs regardless of the HPV status. The high prevalence of PD-L1 expression suggests that patients with micropapillary ECAs may be good candidates for PD-L1 inhibitor treatment.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"801-808"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MSH2-Mutated Lynch Syndrome With 9 Synchronous Colon and Rectum Adenocarcinomas: An Extremely Rare Case Report. MSH2突变林奇综合征伴有9个同步的结肠和直肠腺癌：极为罕见的病例报告

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-06-01 Epub Date: 2024-11-18 DOI: 10.1177/10668969241295691

Haluk Kavus, Robert Patrick Dorion

{"title":"MSH2-Mutated Lynch Syndrome With 9 Synchronous Colon and Rectum Adenocarcinomas: An Extremely Rare Case Report.","authors":"Haluk Kavus, Robert Patrick Dorion","doi":"10.1177/10668969241295691","DOIUrl":"10.1177/10668969241295691","url":null,"abstract":"Synchronous colorectal carcinoma is having more than 1 primary carcinoma detected in a single patient at the same time or within 6 months of tumor diagnosis. Metachronous colorectal carcinoma is the presence of more than 1 primary carcinoma detected consecutively in a single person after a set time interval. Patients with Lynch syndrome and Muir-Torre syndrome (a subset of Lynch syndrome) inherit a germline mutation in 1 of the mismatch repair (MMR) genes. Patients with synchronous colorectal carcinoma have a higher proportion of MMR-mutated cancers than patients with solitary colorectal carcinoma. Most studies in the literature indicate that patients with synchronous colorectal cancers typically have only 2 carcinomas. However, there have been reports of a single patient having up to 6 synchronous carcinomas in the large intestine. This report discusses a patient with 9 simultaneous colorectal cancers at the initial diagnosis, along with a history of bladder cancer, sebaceous adenoma, and duodenal adenoma, associated with a germline mutS homolog 2 (MSH2) mutation. Additionally, the report explores various aspects of having synchronous colorectal cancers. More studies are needed to clarify the clinicopathologic and molecular landscape of these rare tumors and identify the best management and treatment strategies for these patients.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1062-1067"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Collision of Endometrioid Adenocarcinoma and Second Recurrent Low-Grade Endometrial Stromal Sarcoma 8 Years After Hysterectomy: A Case Report and Literature Review. 子宫内膜样腺癌与第二次复发的低级别子宫内膜间质肉瘤在子宫切除术后 8 年的罕见碰撞：病例报告和文献综述。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-06-01 Epub Date: 2024-11-18 DOI: 10.1177/10668969241295356

Xinyi Wang, Yue Zhou, Weiru Zhang, Yang Li, Yanhui Ma, Peishu Liu

{"title":"A Rare Collision of Endometrioid Adenocarcinoma and Second Recurrent Low-Grade Endometrial Stromal Sarcoma 8 Years After Hysterectomy: A Case Report and Literature Review.","authors":"Xinyi Wang, Yue Zhou, Weiru Zhang, Yang Li, Yanhui Ma, Peishu Liu","doi":"10.1177/10668969241295356","DOIUrl":"10.1177/10668969241295356","url":null,"abstract":"Low grade endometrial stromal sarcoma (LG-ESS) is a rare malignancy of mesenchymal origin in the female reproductive system, which has the characteristic of late recurrence. Endometrial carcinoma is a group of epithelial tumors, and is one of the most common gynecological malignancies among women worldwide. The coexistence of LG-ESS and endometrial carcinoma is extremely rare, and there is no relevant report about the collision of endometrial carcinoma and recurrent LG-ESS currently. In the present study, we report a tumor of recurrent LG-ESS accompanied with endometrioid adenocarcinoma in a young patient 8 years after hysterectomy. She was first diagnosed with LG-ESS at the age of 19 and received fertility-sparing therapy. During the 13-year follow-up period, she successfully delivered and experienced two recurrences of LG-ESS, and an unexpected endometrioid adenocarcinoma component was found in the second recurrent tumor. Adjuvant chemotherapy and endocrine therapy were administrated to the patient after completely removing the tumor, and no sign of disease recurrence or metastasis were found 7 months after the last surgery. This study emphasizes the importance of long-term management of LG-ESS and brings new insights to clinicians and pathologists about collision tumors involving recurrent tumor.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1040-1044"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myxoid Solitary Fibrous Tumor of the Nasal Vestibule: An Unusual Histological Subtype in the Head and Neck Region. 鼻前庭肌样孤立性纤维瘤：头颈部一种不寻常的组织学亚型。

IF 0.9 4区医学

International Journal of Surgical Pathology Pub Date : 2025-06-01 Epub Date: 2024-11-13 DOI: 10.1177/10668969241295357

Aswini Prabakaran, Aanchal Kakkar, Hitesh Verma, Deepali Jain

{"title":"Myxoid Solitary Fibrous Tumor of the Nasal Vestibule: An Unusual Histological Subtype in the Head and Neck Region.","authors":"Aswini Prabakaran, Aanchal Kakkar, Hitesh Verma, Deepali Jain","doi":"10.1177/10668969241295357","DOIUrl":"10.1177/10668969241295357","url":null,"abstract":"Solitary fibrous tumors (SFTs) are mesenchymal neoplasms associated with the characteristic NAB2::STAT6 gene fusion. They frequently occur in extra-thoracic sites and are not uncommon in the head and neck (HN) region. Myxoid SFT is a rare morphological subtype of SFT, the features of which overlap with those of other myxoid-appearing tumors, making the diagnosis challenging. We describe the distinctive histopathological and immunohistochemical features of myxoid SFT that occurred in a 32-year-old man with a recurrent swelling in the nasal vestibule. Histological examination showed a nodular tumor composed of short spindle-shaped cells in an abundant myxoid stroma. Nuclei were ovoid, with minimal pleomorphism. Occasional intervening slender vascular channels were present; staghorn vasculature was absent. Tumor cells were diffusely immunopositive for STAT6, CD34, and BCL2, while S100, SOX10, EMA, ER, and CD10 were negative, confirming the diagnosis of myxoid SFT. Thus, myxoid SFTs are unusual in the HN, with potential for misdiagnosis. Due to their propensity for local recurrence if incompletely excised, a high index of suspicion is required to include them in differential diagnosis of myxoid mesenchymal neoplasms occurring at this location. STAT6 is a reliable immunohistochemical marker that aids in diagnosis, reducing the necessity for molecular testing.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"1034-1039"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0