International Journal of Surgical Pathology最新文献_第2页

Cystic Hepatic Lesions: A Concise Review of Literature. 囊性肝病变：简明文献综述。

IF 1 4区医学

International Journal of Surgical Pathology Pub Date : 2026-05-06 DOI: 10.1177/10668969261438514

Anu Abraham, Varsha Prakash, Akhila Aravind, Neha Varshney

引用次数: 0

Epithelioid Fibrous Histiocytoma with LRRFIP1::ALK Fusion and Smooth Muscle Hyperplasia. 上皮样纤维组织细胞瘤伴LRRFIP1: ALK融合和平滑肌增生。

IF 1 4区医学

International Journal of Surgical Pathology Pub Date : 2026-05-06 DOI: 10.1177/10668969261445048

Eric Davenne, Alex Fortun, Marine Matthews, Léo-Paul Secco

引用次数: 0

Automatic Detection of Ganglion Cells as a Supporting Tool for Hirschsprung Disease Diagnosis. 神经节细胞自动检测作为巨结肠疾病诊断的辅助工具。

IF 1 4区医学

International Journal of Surgical Pathology Pub Date : 2026-05-05 DOI: 10.1177/10668969261437754

Andrés Siabatto-Cleves, Paula Toro, Natalia Olaya, Kevin Maldonado-Cañón, Edna Quintero, Fernando Fierro, Germán Corredor

{"title":"Automatic Detection of Ganglion Cells as a Supporting Tool for Hirschsprung Disease Diagnosis.","authors":"Andrés Siabatto-Cleves, Paula Toro, Natalia Olaya, Kevin Maldonado-Cañón, Edna Quintero, Fernando Fierro, Germán Corredor","doi":"10.1177/10668969261437754","DOIUrl":"https://doi.org/10.1177/10668969261437754","url":null,"abstract":"Hirschsprung disease (HD) is a congenital disorder characterized by the absence of ganglion cells in the colonic nervous plexuses, resulting in bowel obstruction and various complications. The diagnosis of HD demands expertise, experience, and ancillary tests. Our objective was to design an artificial intelligence (AI) tool to facilitate the diagnostic process of HD and evaluate its performance in terms of sensitivity, specificity, and average area under the curve (AUC). Using a camera-equipped microscope, we digitized 222 high-power fields of view obtained from H&E-stained slides. Nuclei were segmented using a deep learning algorithm and manually annotated by an expert pathologist. From these, 2076 nuclei were selected, including 346 ganglion cells and 1730 non-ganglion cells. A set of 100 features related to shape, color, and texture was extracted from the nuclei. To evaluate their utility in distinguishing the two categories, a cross-validation scheme was employed. The nuclei were randomly divided into training (70%) and validation sets (30%). The Wilcoxon signed-rank test was employed to identify the top features in the training set, which were then used to train an AI classifier to distinguish between the two categories: Ganglion cell and non-ganglion cell. The classifier's performance was assessed using the validation set, yielding an average AUC = 0.98. The classifier's performance was assessed using the validation set, yielding an average AUC = 0.98. Taken together, our findings indicate that this AI-driven framework may serve as a valuable support tool for pathologists, facilitating the diagnosis of HD in routine clinical practice.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261437754"},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenomatoid Tumor of the Uterus With Marked Nuclear Atypia: A Case Report Including Next-Generation Sequencing Analysis and Review of the Literature. 子宫腺瘤样肿瘤伴显著核异型：1例报告，包括新一代测序分析和文献复习。

IF 1 4区医学

International Journal of Surgical Pathology Pub Date : 2026-05-05 DOI: 10.1177/10668969261443548

Jiří Lenz, Květoslava Michalová, Nikola Ptáková, Miroslav Kavka, Veronika Slonková, Jana Černá, Luděk Fiala

{"title":"Adenomatoid Tumor of the Uterus With Marked Nuclear Atypia: A Case Report Including Next-Generation Sequencing Analysis and Review of the Literature.","authors":"Jiří Lenz, Květoslava Michalová, Nikola Ptáková, Miroslav Kavka, Veronika Slonková, Jana Černá, Luděk Fiala","doi":"10.1177/10668969261443548","DOIUrl":"https://doi.org/10.1177/10668969261443548","url":null,"abstract":"Adenomatoid tumor is a rare benign neoplasm of mesothelial origin occurring in various anatomical locations, including the uterus. In this article, we describe an adenomatoid tumor of the uterus exhibiting severe nuclear atypia in the clinical context of long-term hormone therapy. The patient was a 51-year-old woman who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for uterine leiomyomas. Gross evaluation of the uterus revealed multiple intramural and subserosal unencapsulated nodules that were both well and poorly circumscribed and measured from 4 to 25 mm. Microscopically, one of the nodules consisted of hyperplastic leiomyocytes intermixed with irregular vascular-like and tubular spaces lined by flattened cells that occasionally showed moderate to severe nuclear atypia (enlargement, hyperchromasia, and multinucleation). Bizarre pleomorphic cells were also present. Mitotic activity was minimal. The tumor cells showed diffuse positivity for calretinin, keratin AE1/AE3, L1 cell adhesion molecule, and podoplanin, while CD31, CD34, epithelial membrane antigen, HMB45, MDM2, and S100 protein stains were negative. Expression of BRCA1-associated deubiquitinase 1 and methylthioadenosine phosphorylase was retained. This immunophenotype supported a mesothelial origin of the neoplastic cells, leading to the final diagnosis of adenomatoid tumor with marked nuclear atypia. Unusual histopathological findings in adenomatoid tumors, such as marked nuclear atypia and pleomorphism, may pose significant diagnostic challenges and result in misdiagnosis. Despite these unusual features, the tumor in our study showed no evidence of aggressive behavior or malignant transformation. Although we hypothesize that these changes may be related to prolonged hormone therapy, their pathogenesis and clinical significance remain unclear, underscoring the need for further investigation.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261443548"},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Assessing Stromal Invasion and Staging Cervical Carcinomas Arising In or Confined to Endocervical Polyps. 评估发生于或局限于宫颈内息肉的间质浸润和宫颈癌分期的挑战。

IF 1 4区医学

International Journal of Surgical Pathology Pub Date : 2026-05-05 DOI: 10.1177/10668969261439139

Hisham F Bahmad

{"title":"Challenges in Assessing Stromal Invasion and Staging Cervical Carcinomas Arising In or Confined to Endocervical Polyps.","authors":"Hisham F Bahmad","doi":"10.1177/10668969261439139","DOIUrl":"https://doi.org/10.1177/10668969261439139","url":null,"abstract":"The staging of cervical carcinomas that appear confined to endocervical polyps presents a rare but recurring diagnostic and reporting challenge. Current classification systems, including the International Federation of Gynecology and Obstetrics (FIGO) 2018 staging system, the American Joint Committee on Cancer (AJCC) eighth edition, and College of American Pathologists (CAP) protocols, do not provide specific guidance for this scenario. Endocervical polyps are typically benign lesions, but in rare instances they may harbor invasive carcinoma. When invasion appears limited to the polyp stroma, assessment of the depth of invasion and assignment of a pathologic stage becomes challenging due to the polyp's limited, distorted, or fragmented architecture. Importantly, it is often difficult in routine practice to distinguish a truly polyp-confined carcinoma from an exophytic cervical tumor involving a polyp. This review highlights the gaps in staging of cervical carcinomas arising in or confined to endocervical polyps and draws cautious conceptual parallels to staging approaches in other organ systems, not to propose guideline changes, but to highlight existing gaps and reporting ambiguities. Currently, for reporting and staging purposes, pathologists use the same approach as that for other exophytic tumors. Here, we emphasize standardized documentation and transparent reporting of staging limitations as a practical interim approach, while acknowledging the absence of evidence sufficient to support formal staging modifications. Until additional data are available, careful descriptive reporting may facilitate clinical decision-making and enable future data collection needed to inform evidence-based revisions.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261439139"},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to "Clinical-Imaging Discordance in Suspected Osteoid Osteoma: Importance of Targeted CT Evaluation". 答复“疑似骨样骨瘤的临床-影像学不一致：靶向CT评价的重要性”。

IF 1 4区医学

International Journal of Surgical Pathology Pub Date : 2026-05-05 DOI: 10.1177/10668969251414708

Shunsuke Koga, Wei Du, Cara A Cipriano, Kumarasen Cooper

引用次数: 0

Rosai-Dorfman Disease of the Breast: A Case Series and Review of the Literature. 乳腺Rosai-Dorfman病：病例系列及文献回顾。

IF 1 4区医学

International Journal of Surgical Pathology Pub Date : 2026-05-04 DOI: 10.1177/10668969261438513

Alba Rebecca Hernandez Guzman, Romina Malerba, Yuan Rong, Israh Akhtar, Ashish Bains, Jalil Nasibli, Maria F Gonzalez

{"title":"Rosai-Dorfman Disease of the Breast: A Case Series and Review of the Literature.","authors":"Alba Rebecca Hernandez Guzman, Romina Malerba, Yuan Rong, Israh Akhtar, Ashish Bains, Jalil Nasibli, Maria F Gonzalez","doi":"10.1177/10668969261438513","DOIUrl":"https://doi.org/10.1177/10668969261438513","url":null,"abstract":"ContextRosai-Dorfman disease is a rare histiocytic disorder that primarily affects lymph nodes but may present at extranodal sites. Breast involvement is exceptionally rare and often mimics malignancy on clinical and imaging studies, leading to diagnostic challenges.ObjectiveTo describe the clinical, radiologic, and pathologic features of breast Rosai-Dorfman disease and review management outcomes.DesignWe retrospectively reviewed all instances of breast Rosai-Dorfman disease diagnosed at our institution over a 14-month period. Clinical records, imaging studies, histopathology, treatment, and follow-up data were analyzed.ResultsA total of three patients were diagnosed with Rosai-Dorfman disease of the breast. All three patients were women aged 22 to 71 years. Two presented with palpable breast masses, and one patient had a mass that was incidentally detected on chest computed tomography. Imaging demonstrated irregular masses categorized as Breast Imaging Reporting and Data System (BI-RADS) category 4-5, suspicious for carcinoma. Histopathologic examination showed dense lymphoplasmacytic infiltrates with histiocytes exhibiting emperipolesis and immunoreactivity for S100, CD68, and CD163, with negative CD1A staining. Two patients underwent excision, and one was managed conservatively. At follow-up, all patients remained disease-free without recurrence or systemic involvement.ConclusionsBreast Rosai-Dorfman disease is a rare benign entity that closely mimics carcinoma both clinically and radiologically. Accurate diagnosis relies on histopathologic evaluation with immunohistochemistry. Management may range from observation to surgical excision depending on lesion size and symptoms. Awareness of this presentation is essential to prevent misdiagnosis and overtreatment.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"10668969261438513"},"PeriodicalIF":1.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NUT Carcinoma of the Lacrimal Apparatus Presenting as a Rapidly Enlarging Medial Canthal Mass: A Case Report. 泪器NUT癌表现为快速扩大的内侧眦肿块1例。

IF 1 4区医学

International Journal of Surgical Pathology Pub Date : 2026-05-04 DOI: 10.1177/10668969261439157

Pratiksha Vidhe Sharma, Harshala H Lokhande, Shruti Vimal

引用次数: 0

Gastric Lipomatosis: A Case Report. 胃脂肪瘤病1例。

IF 1 4区医学

International Journal of Surgical Pathology Pub Date : 2026-05-01 Epub Date: 2025-04-15 DOI: 10.1177/10668969251333114

Seung Ho Sin, Kwang-Il Yim, Junhyun Lee, Eun Young Kim

引用次数: 0

Eosinophilic Solid and Cystic Renal Cell Carcinoma (ESC RCC): Clinicopathologic Study of a Series of 4 Patients from Brazil With Report of Cell Cannibalism as a Novel Microscopic Finding. 嗜酸性实体和囊性肾细胞癌（ESC RCC）：巴西4例患者的临床病理研究，细胞同类相食是一种新的显微镜发现。

IF 1 4区医学

International Journal of Surgical Pathology Pub Date : 2026-05-01 Epub Date: 2025-11-14 DOI: 10.1177/10668969251382815

Athanase Billis, Ana P C Queiroz, Ana Yoshie, Leandro L L Freitas

{"title":"Eosinophilic Solid and Cystic Renal Cell Carcinoma (ESC RCC): Clinicopathologic Study of a Series of 4 Patients from Brazil With Report of Cell Cannibalism as a Novel Microscopic Finding.","authors":"Athanase Billis, Ana P C Queiroz, Ana Yoshie, Leandro L L Freitas","doi":"10.1177/10668969251382815","DOIUrl":"10.1177/10668969251382815","url":null,"abstract":"We report the clinicopathological findings of the first series of 4 patients from Brazil with eosinophilic solid and cystic renal cell carcinoma (ESC RCC). In our study, there were 3 female patients and 1 male patient. The youngest female patient had bilateral tumors and a past history of tuberous sclerosis. The morphologic findings were in accordance with the literature. Macroscopically, the tumors were nonencapsulated disclosing solid, macrocystic and/or microcystic arrangement. In the largest tumor the arrangement was purely solid with frequent and extensive necrosis. The characteristic and distinctive morphologic feature of the tumors was the \"stippling.\" The tumoral cells disclosed abundant eosinophilic cytoplasm, containing characteristically thin or coarse basophilic or purple granules. Not rarely, the granules were surrounded by a clear halo imparting a \"leishmania-like\" aspect which is an additional frequent feature of ESC RCC. A novel morphologic finding of ESC RCC in our series was the presence of \"cell cannibalism\" in the largest tumor and with extensive necrosis. \"Cell cannibalism\" may be associated with aggressiveness of the tumor cells. All 4 patients are alive and without tumor progression, but the follow-up of our series was short.","PeriodicalId":14416,"journal":{"name":"International Journal of Surgical Pathology","volume":" ","pages":"724-734"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145523548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0