Clival Chordoma Metastatic to Lymph Node: Brachyury Staining Insights.

Abstract

Clival chordomas are rare bone tumors involving the primary intracranial central nervous system. These tumors reoccur and invade locally but metastasis is uncommon. We present a 54-year-old woman with a 10-year recurrence of a conventional chordoma originating from the clivus with lymph node metastasis that was confirmed with brachyury. Based on our review of the literature, there have been only 3 confirmed patients with clival chordoma metastasis to lymph nodes and this is the first account of a conventional chordoma lymph node metastasis being confirmed with brachyury immunohistochemistry.