Polythelia (Supernumerary Nipple): Clinicopathological Characterization of an Atavistic Lesion.

IF 0.9 4区 医学 Q4 PATHOLOGY
Majd Al Assaad, Diana R Vulcain, Andy Phan, Baris Boyraz, Syed A Hoda
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引用次数: 0

Abstract

Polythelia refers to the presence of additional nipples typically located along the "milk line." While its atavistic nature and associations with congenital anomalies are well documented, its clinicopathological features are less defined. This retrospective study reviewed 131 lesions diagnosed as polythelia in 112 patients from 1999 to 2024. The median age of patients at the time of excision was 28 years (range: 6 months to 72 years). Most (101, 90.2%) patients were female. Lesions were located around the breast (42%), chest (28%), axilla (15%), inframammary fold (8%), and abdomen (6%). Histopathology of 107 lesions showed breast glandular tissue in 83 (77.6%). Sixty (72.3%) of these also exhibited nipple-type smooth muscle, and 24 (22.4%) contained smooth muscle only. Among lesions with glandular tissue, 66/83 (79.5%) had ducts, and 17/83 (20.5%) exhibited lobules. In addition, 54 lesions, initially misdiagnosed as accessory nipples, were reclassified as "clinical pseudo-polythelia." The latter included nevi (48.1%), seborrheic keratosis (13.0%), and hemangiomas (3.7%). Based on our study, polythelia (when encountered in routine practice) is typically a benign and solitary lesion, excised for cosmetic reasons in younger females. Although one lesion of ductal carcinoma in situ in polymastia, under a polythelia, was encountered, no tumor with any nipple or breast lesion was identified in polythelia per se. No other congenital diseases or medical condition was identified in our cohort; however, there were ipsilateral or contralateral malignancies in the native breast in 7.6% of the lesions. Recognition of polythelia is essential to distinguish it from other skin lesions.

多乳头:一种返祖性病变的临床病理特征。
多乳头指的是通常位于“乳线”的额外乳头的存在。虽然它的返祖性和与先天性异常的关联是有充分记录的,但其临床病理特征却不太明确。本回顾性研究回顾了1999年至2024年112例诊断为多发性息肉的131个病变。患者在切除时的中位年龄为28岁(范围:6个月至72岁)。女性占绝大多数(101.90.2%)。病变位于乳房周围(42%)、胸部(28%)、腋窝(15%)、乳下襞(8%)和腹部(6%)。107例病变组织病理学显示乳腺腺组织83例(77.6%)。其中乳头型平滑肌60例(72.3%),仅平滑肌24例(22.4%)。腺组织病变中,导管病变66/83(79.5%),小叶病变17/83(20.5%)。此外,54个最初误诊为副乳头的病变被重新分类为“临床假性多绒毛瘤”。后者包括痣(48.1%)、脂溢性角化病(13.0%)和血管瘤(3.7%)。根据我们的研究,多毛(在常规手术中遇到的)通常是一种良性和孤立的病变,在年轻女性中因美容原因切除。虽然在多乳房瘤下发现了一例导管原位癌,但在多乳房瘤中没有发现任何乳头或乳房病变的肿瘤。在我们的队列中没有发现其他先天性疾病或医疗状况;然而,在7.6%的病灶中存在同侧或对侧恶性肿瘤。多毛症的识别对于将其与其他皮肤病变区分开来至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.10
自引率
0.00%
发文量
198
审稿时长
1 months
期刊介绍: International Journal of Surgical Pathology (IJSP) is a peer-reviewed journal published eight times a year, which offers original research and observations covering all major organ systems, timely reviews of new techniques and procedures, discussions of controversies in surgical pathology, case reports, and images in pathology. This journal is a member of the Committee on Publication Ethics (COPE).
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