International Journal of STD & AIDS最新文献

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Changing epidemiology and clinical presentation of rectal lymphogranuloma venereum in the HIV-PrEP era: A comparative study from Bologna, Italy. HIV-PrEP时代直肠性病性淋巴肉芽肿的流行病学变化和临床表现:来自意大利博洛尼亚的比较研究。
IF 1.6 4区 医学
International Journal of STD & AIDS Pub Date : 2026-07-01 Epub Date: 2026-04-02 DOI: 10.1177/09564624261437167
Valeria Gaspari, Leonardo Calza, Simone Ambretti, Tiziana Lazzarotto, Marielle Ezekielle Djusse, Lorenzo Badia, Claudio Foschi, Antonella Marangoni
{"title":"Changing epidemiology and clinical presentation of rectal lymphogranuloma venereum in the HIV-PrEP era: A comparative study from Bologna, Italy.","authors":"Valeria Gaspari, Leonardo Calza, Simone Ambretti, Tiziana Lazzarotto, Marielle Ezekielle Djusse, Lorenzo Badia, Claudio Foschi, Antonella Marangoni","doi":"10.1177/09564624261437167","DOIUrl":"10.1177/09564624261437167","url":null,"abstract":"<p><p>IntroductionLymphogranuloma venereum (LGV), caused by <i>Chlamydia trachomatis</i> (CT) serovars L1-L3, has re-emerged in Europe since the early 2000s, predominantly affecting men who have sex with men (MSM), particularly people living with HIV (PLWH). The widespread implementation of HIV pre-exposure prophylaxis (HIV-PrEP) and the associated expansion of sexually transmitted infection (STI) screening programmes may have influenced the epidemiology and clinical presentation of LGV. MethodsWe analysed the clinical and epidemiological characteristics of rectal LGV cases diagnosed in the Bologna metropolitan area during the HIV-PrEP era (2022-2025) and compared them with those of a historical cohort from the pre-HIV-PrEP era (2016-2020). ResultsOverall, 93 rectal LGV cases were identified during 2022-2025, all among MSM, with a median age of 37 years; 66% were symptomatic, 48% were HIV-positive, 31% had concurrent rectal <i>Neisseria gonorrhoeae</i> infection, and 21% were diagnosed with early syphilis. Although the absolute number of LGV cases was higher than in 2016-2020 (93 vs 76), this difference occurred in the context of a substantial increase in anorectal CT testing during the HIV-PrEP era. Accordingly, LGV prevalence among anorectal swabs declined markedly (from 4% to 0.7%). When stratified by population group, HIV-PrEP users with LGV (<i>n</i> = 38) were younger than non-HIV PrEP users (<i>n</i> = 55, including 45 PLWH and 10 non-HIV MSM) and were significantly more likely to be asymptomatic, with lower rates of concurrent bacterial STIs.ConclusionThese findings suggest that rectal LGV remains endemic in our setting but may present with different clinical patterns in the HIV-PrEP era, with a higher proportion of asymptomatic infections among PrEP users, likely reflecting intensified STI screening. Continued epidemiological surveillance is needed to better understand LGV transmission dynamics and to inform tailored prevention and screening strategies among MSM.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"927-930"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Condom-use decision making among pre-exposure prophylaxis (PrEP) users in a pharmacy-delivered PrEP project in South Africa: Qualitative insights from PPrEPP-SA. 南非药房提供的PrEP项目中暴露前预防(PrEP)使用者的安全套使用决策:来自PrEP - sa的定性见解
IF 1.6 4区 医学
International Journal of STD & AIDS Pub Date : 2026-07-01 Epub Date: 2026-04-13 DOI: 10.1177/09564624261442291
Mafanato Gladys Maluleka, Kelechi Elizabeth Oladimeji, Leanne Singh, Nokukhanya Ntombela, Thato Motlalane-Kopanye, Lindisipo Zangqa, Athini Nyatela, Angela Tembo, Samanta Tresha Lalla-Edward
{"title":"Condom-use decision making among pre-exposure prophylaxis (PrEP) users in a pharmacy-delivered PrEP project in South Africa: Qualitative insights from PPrEPP-SA.","authors":"Mafanato Gladys Maluleka, Kelechi Elizabeth Oladimeji, Leanne Singh, Nokukhanya Ntombela, Thato Motlalane-Kopanye, Lindisipo Zangqa, Athini Nyatela, Angela Tembo, Samanta Tresha Lalla-Edward","doi":"10.1177/09564624261442291","DOIUrl":"10.1177/09564624261442291","url":null,"abstract":"<p><p>BackgroundCommunity pharmacies increasingly serve as access points for HIV pre-exposure prophylaxis (PrEP) in South Africa and understanding how PrEP users in these settings make decisions about condom-use is essential to inform effective combination prevention strategies. This study explored condom-use decision-making among PrEP users accessing pharmacy-delivered services in South Africa.MethodsThis qualitative study formed part of the midline evaluation of the PPrEPP-SA project. In-depth interviews were conducted between March and May 2024. Interviews explored participants' understanding of PrEP, sexual behaviours, perceptions of HIV/STI risk, and experiences with prevention methods. Audio-recorded interviews were transcribed verbatim and analysed thematically using Braun and Clarke's inductive approach.Results69 PrEP users aged 18-59 years were recruited from 10 community pharmacies across Gauteng and the Western Cape. Participants demonstrated varied and often negotiated condom-use practices while on PrEP. While most understood PrEP as effective for HIV prevention, some held misconceptions regarding its ability to prevent STIs, contributing to reduced condom-use. Decisions to forego condoms were linked to trust in partners, relationship stability, cohabitation, and preferences for condomless physical intimacy. Condom-use was more likely in casual partnerships or when partner HIV status was unknown. Participants also expressed a strong preference for purchased condoms over free public-sector condoms, citing concerns about quality and durability.ConclusionCondom-use among pharmacy-based PrEP users is context-dependent, shaped by relationships, risk perceptions, and understandings of PrEP. In South Africa, pharmacy-delivered PrEP programmes provide a critical opportunity to reinforce dual prevention messaging, address misconceptions, and improve access to acceptable, high-quality condoms as part of comprehensive HIV and sexual health prevention.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"853-860"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium-glucose cotransporter-2 inhibitor therapy and penile lichen sclerosus: Clinical observations suggesting a role in disease development through urinary occlusion. 钠-葡萄糖共转运蛋白-2抑制剂治疗和阴茎硬化地衣:临床观察提示通过尿路闭塞在疾病发展中的作用。
IF 1.6 4区 医学
International Journal of STD & AIDS Pub Date : 2026-07-01 Epub Date: 2026-04-19 DOI: 10.1177/09564624261437602
Georgios Kravvas, Christopher Barry Bunker
{"title":"Sodium-glucose cotransporter-2 inhibitor therapy and penile lichen sclerosus: Clinical observations suggesting a role in disease development through urinary occlusion.","authors":"Georgios Kravvas, Christopher Barry Bunker","doi":"10.1177/09564624261437602","DOIUrl":"10.1177/09564624261437602","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"921-922"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13276100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective associations between treatment for drug-use and sexually transmitted infections across racial and ethnic groups of women. 跨种族和族裔妇女群体药物使用治疗与性传播感染之间的前瞻性关联。
IF 1.6 4区 医学
International Journal of STD & AIDS Pub Date : 2026-07-01 Epub Date: 2026-04-15 DOI: 10.1177/09564624261443180
Joy D Scheidell, Jacob Bleasdale, Bedis Elkamel, Ariana Valentin, Typhanye V Dyer
{"title":"Prospective associations between treatment for drug-use and sexually transmitted infections across racial and ethnic groups of women.","authors":"Joy D Scheidell, Jacob Bleasdale, Bedis Elkamel, Ariana Valentin, Typhanye V Dyer","doi":"10.1177/09564624261443180","DOIUrl":"10.1177/09564624261443180","url":null,"abstract":"<p><p>BackgroundAlthough treatment for drug-use reduces HIV/HCV risk, little is known about its relationship with other sexually transmitted infections (STIs) among women who use drugs. We examined the prospective association between receipt of treatment for drug use and incident STIs, and whether associations differ across racial and ethnic groups among women who use drugs.MethodsWe conducted a secondary analysis of a 2010 longitudinal cohort among women participants who reported drug use at baseline (<i>n</i> = 826). Participants completed surveys and STI testing at baseline and 6 months. The primary exposure was baseline self-reported receipt of treatment for drug use in the prior 6 months. The outcome was incident chlamydia, gonorrhea, trichomoniasis, and/or syphilis at 6 months follow up. Modified Poisson regression with robust variance estimated race and ethnicity-specific risk ratios (RRs), adjusting for baseline sociodemographic, behavioral, and health factors.ResultsSTI incidence was highest among Black women (22%), followed by Hispanic/Latina women and those of other racial/ethnic groups (14%), and lowest among White women (5%). In unadjusted analyses, treatment for drug-use was associated with higher STI incidence among White women (RR = 2.83; 95% CI: 0.97, 8.29) and women of other racial/ethnic groups (RR = 3.21; 95% CI: 1.21, 8.50). In adjusted models, associations attenuated among White and Hispanic/Latina women, while among women of other racial/ethnic groups, self-help treatment remained associated with elevated STI risk (adjusted RR = 3.03; 95% CI: 1.22, 8.96). No associations were observed among Black women.ConclusionsAmong Black women who use drugs, STI risk may be shaped by structural and network-level factors rather than individual-level treatment for drug use. Integrating STI screening and prevention services into drug-related care settings may address elevated STI vulnerability. Additional research should examine mechanisms underlying racial and ethnic differences and how to reach the diverse population of women who use drugs.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"916-920"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Balancing detection and treatment of syphilis: A proposed alternative approach for opt-out testing in UK urgent care settings. 平衡检测和治疗梅毒:在英国紧急护理设置选择退出测试的建议替代方法。
IF 1.6 4区 医学
International Journal of STD & AIDS Pub Date : 2026-07-01 Epub Date: 2026-04-27 DOI: 10.1177/09564624261445491
Helen Fifer, Margaret Kingston, Patrick French
{"title":"Balancing detection and treatment of syphilis: A proposed alternative approach for opt-out testing in UK urgent care settings.","authors":"Helen Fifer, Margaret Kingston, Patrick French","doi":"10.1177/09564624261445491","DOIUrl":"10.1177/09564624261445491","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"811-812"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methodological considerations on the meta-analysis of doxycycline versus azithromycin for Chlamydia trachomatis in cis-men. 多西环素与阿奇霉素治疗顺性男性沙眼衣原体meta分析的方法学考虑。
IF 1.6 4区 医学
International Journal of STD & AIDS Pub Date : 2026-07-01 Epub Date: 2026-04-20 DOI: 10.1177/09564624261444900
Rhushvi Thakkar, Deepika Raina, Chandana Maji, Vaseem Anjum
{"title":"Methodological considerations on the meta-analysis of doxycycline versus azithromycin for Chlamydia trachomatis in cis-men.","authors":"Rhushvi Thakkar, Deepika Raina, Chandana Maji, Vaseem Anjum","doi":"10.1177/09564624261444900","DOIUrl":"10.1177/09564624261444900","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"931-932"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of doxycycline versus azithromycin for the treatment of Chlamydia trachomatis in cis-men: A systematic review and meta-analysis. 多西环素与阿奇霉素治疗顺性男性沙眼衣原体的疗效和安全性:一项系统综述和荟萃分析。
IF 1.6 4区 医学
International Journal of STD & AIDS Pub Date : 2026-07-01 Epub Date: 2026-03-25 DOI: 10.1177/09564624261435919
Safa Boujemaa, Gurparsad Singh Suri, Gurleen Kaur
{"title":"Efficacy and safety of doxycycline versus azithromycin for the treatment of <i>Chlamydia trachomatis</i> in cis-men: A systematic review and meta-analysis.","authors":"Safa Boujemaa, Gurparsad Singh Suri, Gurleen Kaur","doi":"10.1177/09564624261435919","DOIUrl":"10.1177/09564624261435919","url":null,"abstract":"<p><p>IntroductionTreatment for <i>Chlamydia trachomatis</i> include azithromycin and doxycycline; however, comparative studies in cis-male populations remain limited. This systematic review and meta-analysis assessed the efficacy and safety of azithromycin versus doxycycline for treating chlamydial infections among cis-men.MethodsWe searched PubMed/MEDLINE, Embase, Web of Science, Scopus, Cochrane Central Register of Controlled Trials, CINAHL, and Google Scholar. Randomized controlled trials comparing doxycycline (100 mg twice daily for 7 days) with azithromycin (1 g single dose) in cis-men infected with <i>Chlamydia trachomatis</i> were included. Risk of bias was assessed using the Cochrane RoB 2 tool and meta-analysis was reported in accordance with the PRISMA 2020 guidelines. The primary outcome was microbiological cure at last follow-up. Pooled effect estimates were calculated as odds ratios (ORs) with 95% confidence intervals (CIs) using the random-effects model. Subgroup, meta-regression, publication bias and sensitivity analyses were performed. The protocol was registered in PROSPERO (CRD42024535957).Results10 randomized controlled trials comprising 1172 cis-male participants were included. Overall, 560/602 (93%) participants treated with doxycycline and 504/627 (81%) treated with azithromycin achieved microbiological cure. Meta-analysis demonstrated significantly higher odds of cure with doxycycline compared with azithromycin (OR = 2.525, 95% CI = 1.329-4.796, <i>p</i> = 0.005). Adverse events were not significantly different between groups (<i>p</i> = 0.757). Subgroup analysis showed significant superiority of doxycycline for rectal infection and chlamydia-associated nongonococcal urethritis (<i>p</i> < 0.05), but not for prostate infection (<i>p</i> = 0.745). Sensitivity analysis demonstrated strong reliability and no statistical evidence of publication bias (<i>p</i> > 0.05).ConclusionsDoxycycline demonstrated superior microbiological efficacy compared with azithromycin in cis-men with <i>Chlamydia trachomatis</i>. However, moderate heterogeneity was detected across studies and data for rectal and prostate infections were limited. Consequently, further well-designed trials are required to confirm these findings.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"823-832"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between extreme weather events, mobility, and resource insecurities with HIV vulnerabilities among older adults in Moshi, Tanzania: Cross-sectional findings. 坦桑尼亚Moshi老年人中极端天气事件、流动性和资源不安全与艾滋病毒易感性之间的关系:横断面研究结果
IF 1.6 4区 医学
International Journal of STD & AIDS Pub Date : 2026-07-01 Epub Date: 2026-04-29 DOI: 10.1177/09564624261446403
Carmen H Logie, Andie MacNeil, Andrea Pellatt, Karen Yeates, Nicola West, Frannie MacKenzie, Hamza Rajabu, Anisia Kiwelu, Oswald Urassa, Zerihun Admassu
{"title":"Associations between extreme weather events, mobility, and resource insecurities with HIV vulnerabilities among older adults in Moshi, Tanzania: Cross-sectional findings.","authors":"Carmen H Logie, Andie MacNeil, Andrea Pellatt, Karen Yeates, Nicola West, Frannie MacKenzie, Hamza Rajabu, Anisia Kiwelu, Oswald Urassa, Zerihun Admassu","doi":"10.1177/09564624261446403","DOIUrl":"10.1177/09564624261446403","url":null,"abstract":"<p><p>BackgroundEnvironmental and social hazards shape HIV vulnerabilities in Sub-Saharan Africa. Although older adults (>55) have an HIV prevalence higher than the national average in Tanzania, they are understudied in HIV research. To address this knowledge gap, we examined associations between extreme weather event exposure, mobility, resource insecurities, and HIV vulnerabilities among older adults in Moshi, Tanzania.MethodsWe conducted a cross-sectional survey in Moshi with adults aged ≥50 randomly sampled from the Prospective Urban Rural Epidemiology cohort. We conducted multivariable linear and logistic regression analyses to examine associations between environmental (past-year extreme weather events; recent [past 6- and 1-month] seasonal/weather-related mobility) and social (food, water, and/or sanitation insecurity) hazards, protective factors (social support, resilience), and HIV vulnerabilities (condom use self-efficacy; sexual relationship power; lifetime intimate partner violence). Models were adjusted for age, gender, education, and relationship status.ResultsAmong participants (n = 250; mean age: 60.6 years, SD = 11.1; 72.8% women), over half (56.0%) reported >1 past-year extreme weather. Past-year extreme weather exposure (adjusted beta [aβ] = -1.09, 95% Confidence Interval [CI]: -2.08 to -0.10), past-month mobility (aβ = -2.25, 95%CI: -3.45 to -1.06), past 6-month mobility (aβ = -1.83, 95% CI: -3.17 to -0.48), and low food security (vs high/marginal) (aβ = -0.94, 95% CI: -1.72 to -0.15) were associated with lower condom use self-efficacy. Social support (aβ = 0.11, 95% CI: 0.06- 0.16) and resilience (aβ = 0.28, 95% CI: 0.12-0.44) were associated with increased condom use self-efficacy. Past-month (aβ = -5.03, 95% CI: -7.04 to -3.02) and 6-month (β = -2.59, 95% CI: -4.72 to -0.48) mobility were associated with lower sexual relationship power. Past-month mobility (aOR = 12.31, 95% CI: 2.67-56.80) and sanitation insecurity (aOR = 1.20, 95% CI: 1.10-1.32) were associated with higher intimate partner violence odds.ConclusionsExtreme weather event exposure, seasonal/weather-related mobility, and resource insecurities were associated with HIV vulnerabilities among older adults in Moshi. HIV programs in climate-affected contexts can include older populations and integrate social and environmental hazards.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"892-900"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13279970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial resistance in Neisseria gonorrhoeae in England and Wales; findings from the gonococcal resistance to antimicrobials surveillance programme (GRASP 2024). 英格兰和威尔士淋病奈瑟菌耐药性研究淋球菌抗微生物药物耐药性监测规划(GRASP 2024)的结果。
IF 1.6 4区 医学
International Journal of STD & AIDS Pub Date : 2026-07-01 Epub Date: 2026-04-16 DOI: 10.1177/09564624261443879
Suzy Sun, Prarthana Narayanan, Melissa Jansen van Rensburg, Anna Vickers, Sandhya Vivekanand, Penelope Cliff, Rachel Pitt-Kendall, Sandra David, Ella Breese, Emma Callan, Michelle J Cole, Hamish Mohammed, Katy Sinka, Sarah Alexander, Helen Fifer
{"title":"Antimicrobial resistance in Neisseria gonorrhoeae in England and Wales; findings from the gonococcal resistance to antimicrobials surveillance programme (GRASP 2024).","authors":"Suzy Sun, Prarthana Narayanan, Melissa Jansen van Rensburg, Anna Vickers, Sandhya Vivekanand, Penelope Cliff, Rachel Pitt-Kendall, Sandra David, Ella Breese, Emma Callan, Michelle J Cole, Hamish Mohammed, Katy Sinka, Sarah Alexander, Helen Fifer","doi":"10.1177/09564624261443879","DOIUrl":"10.1177/09564624261443879","url":null,"abstract":"<p><p>BackgroundGonococcal resistance in England and Wales has been monitored since 2000 by the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP). Here we present the findings from the 2024 sentinel data and describe the recent trends in gonococcal susceptibility.MethodsConsecutive <i>N. gonorrhoeae</i> isolates from 22 clinics, collected during August-September 2024, were sent by participating laboratories to the UK Health Security Agency (UKHSA) STI Reference Laboratory (STIRL) for antimicrobial susceptibility testing. Data are linked to the national STI surveillance system and further supplemented by participating sexual health clinics.Results<i>N. gonorrhoeae</i> remains highly susceptible to the first-line treatment, ceftriaxone, with just 1.7% of isolates (25/1,512) having reduced susceptibility (MIC >0.03 mg/L); 3.1% of isolates were resistant to the oral alternative treatment, cefixime (MIC >0.125 mg/L). Reduced susceptibility to azithromycin (ECOFF >1 mg/L) was 13.6%; however, most isolates (87.9%) had an azithromycin MIC of 2 mg/L, immediately above the ECOFF. Most isolates (90.6%) were resistant to tetracycline (MIC >0.5 mg/L). A quarter of isolates (25.9%) were resistant to penicillin (MIC >1 mg/L), nearly double that the proportion in the previous year. Ciprofloxacin susceptibility was predicted from genomic data; resistance decreased from 58.7 in 2023 to 46.4%. Prescribing data demonstrated excellent adherence to the UK guideline for managing infection with <i>N. gonorrhoeae</i>, with 97.0% of individuals receiving the recommended first-line of ceftriaxone 1g intramuscular monotherapy in 2024.ConclusionsCefixime resistance and azithromycin reduced susceptibility levels are concerning and may have implications for their use as second-line treatments in the future. Most isolates were resistant to tetracycline, supporting limited expectations for doxyPEP in reducing <i>N. gonorrhoeae</i> incidence.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"870-875"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemsex-associated drug use amongst men and gender-diverse people having sex with men in the UK: Findings from an online community survey, 2024. 英国男性和性别不同的男男性行为者中化学性相关药物的使用:来自在线社区调查的结果,2024。
IF 1.6 4区 医学
International Journal of STD & AIDS Pub Date : 2026-07-01 Epub Date: 2026-04-28 DOI: 10.1177/09564624261448075
George Baldry, Giulia Habib Meriggi, Dolores Mullen, Helen Corkin, Amelia Andrews, Catherine M Lowndes, David Reid, Catherine H Mercer, John Saunders, Hamish Mohammed, Dana Ogaz
{"title":"Chemsex-associated drug use amongst men and gender-diverse people having sex with men in the UK: Findings from an online community survey, 2024.","authors":"George Baldry, Giulia Habib Meriggi, Dolores Mullen, Helen Corkin, Amelia Andrews, Catherine M Lowndes, David Reid, Catherine H Mercer, John Saunders, Hamish Mohammed, Dana Ogaz","doi":"10.1177/09564624261448075","DOIUrl":"10.1177/09564624261448075","url":null,"abstract":"<p><p>ObjectivesChemsex is the use of select psychoactive drugs to enhance sexual experiences and has been described among gay, bisexual, and other men who have sex with men (GBMSM). We aimed to characterise sexual risk, wellbeing and health-seeking behaviours among GBMSM and gender-diverse people reporting chemsex-associated drug use.MethodsWe analysed data from 'Reducing inequalities in Sexual Health' (RiiSH), an online community survey of 2758 UK-resident men and gender-diverse people having sex with men undertaken in November-December 2024. We compared those reporting chemsex-associated drug use with those who did not, assessing sociodemographic characteristics, well-being, sexual risk behaviours and sexual health service (SHS) engagement.ResultsOverall, 8% (218/2758) reported chemsex-associated drug use in the last year. A higher proportion of participants reporting chemsex-associated drug use in the last year also reported a composite measure of sexual risk based on self-reported behaviours in the previous 3-4 months (e.g. prior bacterial STI diagnosis, ≥5 male condomless anal sex partners) compared to those who did not (85% vs 61%, <i>p</i> < 0.001). They also more frequently reported attending a SHS in the last year (81% vs 57%, <i>p</i> < 0.001). Those reporting chemsex-associated drug use also more frequently reported a long-term limiting mental health condition (36% vs 24%, <i>p</i> < 0.001) and poorer personal wellbeing (e.g. reporting low life satisfaction 36% vs 20%, <i>p</i> < 0.001).ConclusionWhile a minority of participants in this national, community-based sample reported chemsex-associated drug use, this group had higher sexual risk and poorer indicators of wellbeing. Many participants also attended SHSs, reinforcing the key supporting role of SHSs for referral pathways to harm reduction support for those experiencing problematic drug use.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"884-891"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13279977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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