International Journal of STD & AIDS最新文献

{"title":"Game of clades: A global mpox snapshot.","authors":"Muhammad Abbas Abid","doi":"10.1177/09564624241288279","DOIUrl":"10.1177/09564624241288279","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"83-85"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipschütz ulcers: A diagnosis to be considered in the post-COVID-19 era.","authors":"Rodríguez-Hernández Fernando Daniel, Pérez-Cavazos Samantha, Camacho-Ortiz Adrián, Treviño-Salinas Emilio Modesto, Pérez-Barragán Edgar","doi":"10.1177/09564624241289993","DOIUrl":"10.1177/09564624241289993","url":null,"abstract":"<p><p>Lipschütz ulcers (LU) represent a challenging and frequently overlooked diagnosis within the spectrum of genital ulcerations. We present the case of a 25-year-old sexually active woman with painful ulcerative lesions on her vulva, accompanied by general malaise, fatigue, and arthralgia. She had been suffering from mild COVID-19 for 1 month. Sexually transmitted infections and cytomegalovirus were excluded. A biopsy of the lesion confirmed a Lipschütz ulcer.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"80-82"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and mortality of tuberculosis among adults living with HIV/AIDS: A single center, retrospective cohort study in Thailand.","authors":"Hariwong Chaicharoen, Sethapong Lertsakulbunlue, Boonsub Sakboonyarat, Worapong Nasomsong","doi":"10.1177/09564624241289986","DOIUrl":"10.1177/09564624241289986","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) among people living with HIV/AIDS (PLWHA) contributes substantially to morbidity and mortality, particularly in high TB burden countries. Our objective is to investigate the clinical characteristics and mortality rates associated with TB among adult PLWHA over a 10-year period at an urban HIV clinic situated in a high TB burden country.</p><p><strong>Method: </strong>A retrospective cohort study was conducted in 2022. The primary endpoints were clinical characteristics and mortality rate of TB, determined as per 100 person-years among adult PLWHA, presented with a 95% confidence interval. Univariable and multivariable Cox proportional regression analyses were performed to determine risk factors for TB mortality.</p><p><strong>Result: </strong>From January 2012-December 2022, 155 PLWHA receiving a diagnosis of TB were enrolled. The median age was 29 (26.5-48.5) years, and the median CD4 + T cell count was 141 (41.8-252.8) cells/µL, with 60.0% of patients with TB manifesting as disseminated infection. The most involved organs were pulmonary (89.7%), lymph nodes (39.4%) and pleura (14.8%). The treatment outcomes exhibited success in 63.2% of cases, relapse in 5.2%, loss to follow up in 17.4% and death in 14.2%. The overall mortality rate was 18.8 per 100 person-years. Multivariable analyses showed significant factors affecting mortality, including lymph node involvement (adjusted HR 3.5; 95% CI 1.1-10.8) and thrombocytopenia (adjusted HR 74.2; 95% CI 10.0-551.4).</p><p><strong>Conclusion: </strong>TB in PLWHA, commonly presenting as disseminated infection, contributes to high mortality. Lymph node involvement and thrombocytopenia are significant factors contributing to mortality. Tuberculosis preventive treatment should be considered for improved prevention strategies among PLWHA, particularly in high TB burden countries.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"56-64"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual and domestic violence enquiry: A national exploratory survey of asking and telling in sexual health services in the UK.","authors":"Jane Meyrick, Amy Bennett, Kyle McGovern, Charlotte Kite","doi":"10.1177/09564624241286926","DOIUrl":"10.1177/09564624241286926","url":null,"abstract":"<p><strong>Background: </strong>Gender-based violence in the form of domestic and sexual abuse represent a worldwide public health and civil rights issue. Healthcare and sexual health have a central role to play in prevention, particularly in the identification of sexual and domestic violence/abuse within a frontline service in which it often presents. Survivors of sexual violence and abuse commonly pass through sexual health services without being asked about their victimisation. Healthcare should be able to identify survivors, provide first line support, refer to specialist services and link to comprehensive post assault care.</p><p><strong>Methods: </strong>In the first joint study of its kind, the Univeristy of the West of England worked with the British Association for Sexual Health and HIV (BASHH) and their Sexual Violence Specialist Interest Group (SVSIG). We report the findings of a snapshot, non-probability, exploratory survey of current comparative sexual and domestic violence/abuse enquiry practice in Genito Urinary Medicine services across the UK.</p><p><strong>Results: </strong>Sixty-two responding services evidenced variable practice around asking, collating data, referral, training and staff supervision.</p><p><strong>Conclusions: </strong>This benchmarking study of practice in the UK sets a bar against which all services can measure and improve current practice on gender-based violence identification, a crucial role of sexual health services in reducing the inequalities driven harm of undisclosed trauma.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"42-46"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint British Association for Sexual Health and HIV and Royal College of Obstetricians and Gynaecologists national UK guideline for the management of herpes simplex virus (HSV) in pregnancy and the neonate (2024 update).","authors":"Emily Clarke, Raj Patel, Dyan Dickins, Katy Fidler, Allan Jackson, Margaret Kingston, Christine Jones, Hermione Lyall, Marian Nicholson, Emanuela Pelosi, David Porter, Gemma Powell, Elizabeth Foley","doi":"10.1177/09564624241280734","DOIUrl":"10.1177/09564624241280734","url":null,"abstract":"<p><p>This updated national UK guideline offers recommendations on the management of genital herpes simplex virus (HSV) in mothers and pregnant people during pregnancy and within 4 weeks following birth. It includes recommendations for first episode and recurrent HSV, HSV in preterm pre-labour rupture of membranes and in co-infection with HSV and HIV. Recommendations around management of the neonate are made, on prevention of postnatal transmission, management of breastfeeding, and the management of clinically discordant couples. This guideline is aimed at healthcare professionals working in sexual health clinics, maternity units, and those working on postnatal wards and neonatal units in the UK. However, the principles of the recommendations should be adopted across all services, including community care.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"4-23"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing long-acting injectable antiretroviral therapy eligibility and initiation at a safety net academic medical center in the southeastern United States.","authors":"Sarah E Rutstein, Christopher Lopez, Thibaut Davy-Mendez, Harsh Agarwal, Hanna Huffstetler, Angela Perhac, Barbarajean Turner, Joseph J Eron, Vivian Go, Claire E Farel, Kuo-Ping Li, Sonia Napravnik","doi":"10.1177/09564624241289998","DOIUrl":"10.1177/09564624241289998","url":null,"abstract":"<p><p><b>Background:</b> Long-acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) extends dosing intervals from daily to every 8 weeks. Equitable implementation requires anticipating and addressing barriers to use. We described LAI-CAB/RPV eligibility and initiation among persons with HIV (PWH) receiving care at a Southeastern US academic medical center. <b>Methods:</b> We included PWH ≥18 years, in care 01/01/2020-12/31/2021, and participating in the UNC CFAR HIV Clinical Cohort. We characterized LAI-CAB/RPV eligibility, compared those with and without recent detectable viral load (VL), and described clinical outcomes on LAI-CAB/RPV. <b>Results:</b> Among 1672 PWH, 425 (25.4%) had LAI-CAB/RPV drug-resistance. Among 1238 LAI-eligible PWH, 8.9% had detectable VL. Median age was 53 (interquartile range 40, 61), 54.6% were non-Hispanic Black, and 73.6% male. Over one-third lived >50 miles from clinic, one-fifth were uninsured, and 7.4% reported hazardous alcohol use. Gaps in care (prior 12-month) were more common among PWH with detectable VL versus suppressed (23.1% vs 13.9%, <i>p</i> = 0.03). 6/47 initiated LAI-CAB/RPV had detectable VL prior to injection; >95% sustained suppression and those with detectable VL had a rapid decline in viremia. <b>Conclusions:</b> Three-quarters of PWH were eligible for LAI-CAB/RPV, but equitable implementation may require addressing challenges such as distance to care, inconsistent care engagement, and other comorbid conditions, particularly for PWH with viremia.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"47-55"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated IL-10 serum levels are associated with slower serological response following syphilis treatment during pregnancy.","authors":"Martyna Kiolbasa, Agnieszka Kotlarz, Konrad Kaminiów, Maciej Pastuszczak","doi":"10.1177/09564624241303816","DOIUrl":"10.1177/09564624241303816","url":null,"abstract":"<p><strong>Background: </strong>Approximately 50% of pregnant individuals treated for syphilis do not achieve a decline in non-treponemal titers by delivery. The serological response in pregnant persons is significantly slower compared to non-pregnant individuals, with unclear pathogenesis and clinical significance. This study aimed to determine the association between the host immune response and serological outcome in pregnant individuals with syphilis.</p><p><strong>Methods: </strong>Twenty-four females with early syphilis, including 14 pregnant individuals, were included. Pro-inflammatory and regulatory cytokines (IFN-γ, TNF-α, IL-4, IL-1β, IL-10, TGF-β) were measured before treatment and 6 months after penicillin injection.</p><p><strong>Results: </strong>The median time to serological cure was 5 months for pregnant individuals and 2 months for non-pregnant females. Pregnant individuals had significantly higher serum levels of IL-10 and TGF-β at baseline and at 6 months post-treatment compared to non-pregnant individuals (<i>p</i> < .05).</p><p><strong>Conclusions: </strong>A robust regulatory immune response to syphilis may be associated with a slower serological response to therapy during pregnancy.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241303816"},"PeriodicalIF":1.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"How well do we know our patients?\": Further validation of a complexity rating scale for HIV.","authors":"Kim Begley, Don Smith, Handan Wand, Derek Chan, Virginia Furner, Melissa Louise Kelly, Patrick McGrath, Ruth Hennessy, Anthony Price, Lia Purnomo, Bruce Hamish Bowden, Shiraze M Bulsara","doi":"10.1177/09564624241279604","DOIUrl":"10.1177/09564624241279604","url":null,"abstract":"<p><strong>Background: </strong>Despite advances in the management and treatment of HIV, identifying risks for disengagement are essential to maximize positive outcomes. The current study investigated the validity of the Clinical Complexity Rating Scale for HIV (CCRS-HIV), a risk-prediction tool, by assessing agreement between patient and clinician scores of patient complexity.</p><p><strong>Methods: </strong>207 patients completed the patient version of the CCRS-HIV (CCRS-HIV^P), and six Attending Medical Officers (AMOs) caring for those individuals completed the original clinician version (CCRS-HIV^C). Kappa statistics, sensitivity and specificity were used to assess patient-clinician agreement.</p><p><strong>Results: </strong>Patient-clinician agreement was highest for problematic crystal methamphetamine use (86%), polypharmacy (84%) and other physical health concerns (67%). Cut-offs of 40 and 45 for the total CCRS-HIV score were identified as most appropriate, with high sensitivity (79.31% and 76.0% respectively).</p><p><strong>Conclusions: </strong>Overall agreement between the clinician and patient complexity scores was high. These findings provide further evidence of the validity of the scale. The study demonstrates that the unique role of AMOs at the center contributes to them knowing their patients well, allowing them to manage and refer when required for interdisciplinary care which likely contributes to their ongoing engagement in care and may account for the high level of agreement.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1112-1119"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"British Association of Sexual Health and HIV (BASHH) UK guidelines for the management of syphilis in pregnancy and children 2024.","authors":"Margaret Kingston, Janet Wilson, Sarah Dermont, Helen Fifer, Koon Chan, Hermione Lyall, Paddy McMaster, Emma Shawkat, Alex Thomas-Leech","doi":"10.1177/09564624241280387","DOIUrl":"10.1177/09564624241280387","url":null,"abstract":"<p><p>This new guideline details the specific management of syphilis in pregnancy and in children. It is to be used in clinical practice alongside the BASHH UK guidelines for the management of syphilis 2024.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1161-1173"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration of kissing in different intimate positions among men who have sex with men: A cross-sectional study.","authors":"Julien Tran, Christopher K Fairley, Jason J Ong, Catriona S Bradshaw, Ei T Aung, Kate Maddaford, Marcus Y Chen, Jane S Hocking, Eric Pf Chow","doi":"10.1177/09564624241301490","DOIUrl":"10.1177/09564624241301490","url":null,"abstract":"<p><strong>Background: </strong>Despite mounting evidence showing that kissing (tongue-kissing) may transmit gonorrhoea between men who have sex with men (MSM), little data exists on factors influencing the duration of kissing while they are above and/or lying underneath a partner for this population group.</p><p><strong>Methods: </strong>Between May 2019 and March 2020, we invited MSM aged ≥18 years who attended the Melbourne Sexual Health Centre (MSHC) to participate in a survey about the duration of their kissing (minutes) and intimate position while kissing (i.e., kissing while above, or while lying underneath) their most recent partner. Univariable and multivariable negative binomial regressions were performed to examine the associations between the duration of kissing in different intimate positions, and demographic and behavioural characteristics (including age, region of birth, HIV status or PrEP use, and role in anal sex).</p><p><strong>Results: </strong>Of the 965 men with a recent male kissing partner, 89.0% (<i>n</i> = 859) also had sex with that partner. Of the 166 men with a recent female kissing partner, 71.7% (<i>n</i> = 119) also had sex with that partner. Our adjusted analyses showed that, on average, men born in Asia (mean 8.52 vs 11.69 min, <i>p</i> < .001) and South America or the Caribbean (mean 8.61 vs 11.69 min, <i>p</i> = .022) spent less time kissing compared to men born in Oceania, and the same was also observed for kissing while above or lying underneath. Men who had only receptive anal sex spent less time kissing while above than those who only had insertive anal sex (mean 3.04 vs 5.86 min, <i>p</i> < .001).</p><p><strong>Conclusion: </strong>Our study is the first to examine factors that influence duration of kissing in different intimate positions. These factors could be associated with oropharyngeal gonorrhoea if saliva transmitted gonorrhoea and if gravity played a role.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241301490"},"PeriodicalIF":1.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}