Shatila Torabi, Naser Tayyebi Meibodi, Ali Rashtibaf, Zahra Rafiei Vardanjani
{"title":"Angiokeratoma of Fordyce: Two unusual case presentations involving lesions on the clitoris and glans penis.","authors":"Shatila Torabi, Naser Tayyebi Meibodi, Ali Rashtibaf, Zahra Rafiei Vardanjani","doi":"10.1177/09564624251359083","DOIUrl":"https://doi.org/10.1177/09564624251359083","url":null,"abstract":"<p><p>Angiokeratoma of Fordyce is a benign vascular lesion characterized by the dilation of blood vessels within the papillary dermis, accompanied by epidermal acanthosis and hyperkeratosis. This report presents two clinical cases: a 22-year-old woman with a solitary, prominent nodular lesion on the clitoris and a 26-year-old man with asymptomatic violaceous papules on the glans penis. Both cases underscore the clinical presentation, differential diagnoses, and histopathological findings associated with angiokeratoma. The first case was diagnosed through excisional biopsy, revealing orthohyperkeratosis, parakeratosis, and dilated vascular channels, while the second case was confirmed via punch biopsy. Although angiokeratomas are typically asymptomatic, they may occasionally present with bleeding, highlighting the necessity for clinical vigilance. The rarity of these lesions in the genital region emphasizes the importance of accurate diagnosis and management, as they can mimic more serious conditions, including melanoma.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251359083"},"PeriodicalIF":1.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Novela, Bruno Silva, João Matos, Cláudia Pedrosa, Francisca Costa, Ana Cipriano
{"title":"HIV-related extracavitary primary effusion lymphoma presenting as a bronchial mass: Case report.","authors":"Francisco Novela, Bruno Silva, João Matos, Cláudia Pedrosa, Francisca Costa, Ana Cipriano","doi":"10.1177/09564624251362327","DOIUrl":"https://doi.org/10.1177/09564624251362327","url":null,"abstract":"<p><p>We describe a case of human herpesvirus-8 (HHV8) associated extracavitary primary effusion lymphoma (PEL) in a 52-year-old man who initially presented with long-term nonproductive cough, fever, night sweats and loss of weight. Initial blood tests were positive for human immunodeficiency virus (HIV) with CD4 + T-lymphocytes count of 42/mm3. Respiratory opportunistic diseases were excluded. Additional investigation with bronchoscopy revealed a bronchial mass that was biopsied. Histology and immunohistochemical tests confirmed extracavitary PEL associated with HHV-8. Antiretroviral treatment and CHOP regimen chemotherapy was initiated with an effective response. Given its rarity and unusual presentation, this clinical case emphasizes the importance of considering PEL, along with other lymphoproliferative disorders, as a differential diagnosis in patients living with HIV with acquired immune deficiency syndrome (AIDS) with a bronchial mass.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251362327"},"PeriodicalIF":1.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaiberth Antonio Cardona-Arias, Valeria Benítez Cadavid, Camilo Gallego Ramírez, Luis Felipe Higuita-Gutiérrez
{"title":"Incidence of HIV and its associated factors in blood donors from a hemocenter in Medellín, Colombia.","authors":"Jaiberth Antonio Cardona-Arias, Valeria Benítez Cadavid, Camilo Gallego Ramírez, Luis Felipe Higuita-Gutiérrez","doi":"10.1177/09564624251363460","DOIUrl":"https://doi.org/10.1177/09564624251363460","url":null,"abstract":"<p><p>IntroductionHuman Immunodeficiency Virus (HIV) infection remains a global public health concern due to its high morbidity and mortality rates, as well as the significant costs associated with treatment and healthcare services.ObjectiveTo determine the incidence of HIV and its associated factors among blood donors in the city of Medellín, Colombia.MethodsA longitudinal study was conducted using secondary data from 23,122 repeat blood donors at a blood bank in Medellín. The cumulative incidence was estimated along with its 95% confidence interval. Pearson's chi-square test, Fisher's exact test, and relative risk calculations were used to identify associated factors.ResultsThe HIV incidence was 9.1 per 10,000 donors (95% CI: 5.0-13.2). Subgroups with the highest incidence per 10,000 donors included those recruited through mobile blood drives (12.3), individuals under 40 years of age (12.0), men (11.3), and altruistic donors (10.6).ConclusionA relatively low number of new HIV cases was found among repeat donors. However, the identification of subgroups with higher incidence is critical for developing targeted strategies to ensure the safety of these priority populations and to enhance active epidemiological surveillance systems for HIV in the general population.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251363460"},"PeriodicalIF":1.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of <i>Chlamydia trachomatis</i> among men who have sex with men and transgender women attending community-based clinics, Thailand, 2019-2021.","authors":"Jutatip Sillabutra, Sarika Pattanasin, Wachiraporn Wanichnopparat, Akarin Hiransuthikul, Pichitpong Soontornpipit, Sujittra Suriwong, Nittaya Phanuphak, Pratana Satitvipawee","doi":"10.1177/09564624251361337","DOIUrl":"https://doi.org/10.1177/09564624251361337","url":null,"abstract":"<p><p>BackgroundWe assessed the feasibility of point-of-care testing (POC) for <i>Chlamydia trachomatis</i> (CT) among Men who have Sex with Men (MSM) and Transgender Women (TGW) attending community-based clinics (CBOs) in Thailand.MethodsA secondary analysis using data from a study that enrolled participants aged ≥18 years who were at risk of HIV. They were tested for CT and <i>Neisseria gonorrhoeae</i> (NG) using Cepheid Xpert® POC tests. Behaviors were assessed using a questionnaire. Logistic regression was used to evaluate factors associated with CT infections.ResultsA total of 1885 participants were enrolled between 2019 and 2021, with 89.7% identifying as MSM. Of all participants, 15.9% were living with HIV (PLHIV), 20.6% initiated PrEP, 31.7% were already using it, and 31.8% had never used PrEP.Of all participants, 13.4% and 18.8% tested positive for NG and CT, respectively. CT prevalence was associated with age groups: 34.6% in 18-19 years (AOR 3.2), 24.1% in 20-24 years (AOR 1.7), compared to 14.5% in those ≥25 years. CT prevalence was higher in PLHIV (28.3%) compared to those who were HIV-negative and had never used PrEP (17.0%).ConclusionsAlmost one-fifth of Thai MSM and TGW had CT infection. POC testing is feasible and should be integrated into STI screening.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251361337"},"PeriodicalIF":1.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonie Callensee, Stefan Esser, Jasmin Jaeger, Denise Zwanziger, Manuela Kowalczyk, Laven Mavarani, Thimoteus Speer, Anja Gäckler, Sebastian Dolff, Oliver Witzke, Andreas Schoenfeld
{"title":"Dickkopf 3 - A novel biomarker for chronic kidney disease and its progression in people living with HIV?","authors":"Leonie Callensee, Stefan Esser, Jasmin Jaeger, Denise Zwanziger, Manuela Kowalczyk, Laven Mavarani, Thimoteus Speer, Anja Gäckler, Sebastian Dolff, Oliver Witzke, Andreas Schoenfeld","doi":"10.1177/09564624251361331","DOIUrl":"https://doi.org/10.1177/09564624251361331","url":null,"abstract":"<p><p>BackgroundThanks to the great advance in antiretroviral therapy (ART), people living with HIV (PLWH) nowadays have a normal life expectancy. Due to chronic (subclinical) inflammation and long-term intake of potentially nephrotoxic medication, PLWH are at an elevated risk for CKD. Urinary Dickkopf 3 (uDKK3) acts as a noninvasive marker of renal tubular damage and predictor of progressive CKD. It has not been investigated in PLWH.MethodsThis observational study included 427 PLWH from the HIV outpatient clinic of the Department of Dermatology at the University Hospital Essen. We examined uDKK3-to-creatinine levels in PLWH with and without CKD. Renal function evolution was retrospectively assessed in order to investigate the relation between uDKK3 and CKD progression.ResultsUrinary DKK3-to-creatinine concentrations were significantly higher in PLWH with CKD and were associated with lower eGFR according to cystatin C (<i>p</i> = 0·009) and creatinine (<i>p</i> = 0·003). There was a trend towards higher uDKK3-to-creatinine concentrations in progressive CKD compared to non-progressive CKD, without reaching significance (OR 1·27; 95%-CI 0·33-2·08; <i>p</i> = 0·33).ConclusionsUrinary DKK3, a noninvasive marker, not only detects CKD in PLWH, but could also indicate its progression. This could help to identify PLWH with progressive CKD in need of effective treatment.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251361331"},"PeriodicalIF":1.3,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khouloud Mnif, Amani Bouabdallah, Tarak Ben Jemaa, Emna Elleuch, Sami Fendri, Boussayma Hammami, Zeineb Mnif, Salah Boujelben, Chakib Marrakchi, Mounir Ben Jemaa
{"title":"Unusual, gigantic cystic echinococcosis in a woman living with HIV.","authors":"Khouloud Mnif, Amani Bouabdallah, Tarak Ben Jemaa, Emna Elleuch, Sami Fendri, Boussayma Hammami, Zeineb Mnif, Salah Boujelben, Chakib Marrakchi, Mounir Ben Jemaa","doi":"10.1177/09564624251362094","DOIUrl":"https://doi.org/10.1177/09564624251362094","url":null,"abstract":"<p><p>IntroductionCystic echinococcosis, or hydatidosis, is a parasite infection that can occur in humans. It can affect all organs, mostly the liver and the lungs. The number, size and evolution of those cysts is mediated by the immune system. Herein we report an unusual presentation of hydatidosis in an immunocompromised woman who lives with HIV.Case presentationOur patient was a 40-year-old female with a 2-decade history of HIV and echinococcal infection. She was in AIDS stage due to poor medical adherence. She presented a medullar toxicity to Albendazole, a medication she had been taking for years to control the echinococcal cysts, which were stable then. Upon stopping the Albendazole, she presented an enlargement of those cysts. Surgery was mandatory, and revealed five liver cysts, a 12cm-large kidney cyst, and a gigantic 20 cm-large retroperitoneal cyst. They were treated successfully, and the patient has been asymptomatic during the last 4 years since surgery, along with maintained HIV suppression.ConclusionHydatidosis can be negatively affected by immunosuppression such as HIV infection. However, the scarcity of the cases studying this association makes it difficult to fully grasp the possible interactions between those two diseases.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251362094"},"PeriodicalIF":1.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zarifa Orta, Aysun Benli, Arif Atahan Çağatay, Seniha Başaran, Simge Erdem, Sevgi Beşişik
{"title":"Hemophagocytic lymphohistiocytosis syndrome (HLH) in HIV-associated Kaposi sarcoma patients: The first case series from a single center in Türkiye.","authors":"Zarifa Orta, Aysun Benli, Arif Atahan Çağatay, Seniha Başaran, Simge Erdem, Sevgi Beşişik","doi":"10.1177/09564624251355834","DOIUrl":"https://doi.org/10.1177/09564624251355834","url":null,"abstract":"<p><p>BackgroundKaposi sarcoma in people living with HIV and AIDS usually involves slowly progressive skin lesions. Cases of Kaposi sarcoma complicated by hemophagocytic lymphohistiocytosis are rare. In this report, we present the first series of hemophagocytic lymphohistiocytosis cases from Türkiye associated with AIDS and Kaposi sarcoma.MethodsCases of hemophagocytic lymphohistiocytosis in people living with HIV and AIDS and Kaposi sarcoma who met the HLH-2004 diagnostic criteria recommended by the \"Histiocyte Society\" were included in the study. The patient's demographic, clinical, and laboratory characteristics were recorded retrospectively.ResultsFour patients presented with fever, cytopenia, peripheral lymphadenomegaly, splenomegaly, and hepatomegaly. Fever persisted throughout their hospitalization. At the time of HLH diagnosis, Kaposi sarcoma was detected in the lymph node biopsies of one patient and in the skin biopsies of three patients. Hemophagocytosis was observed in bone marrow aspirations from all patients. Three patients received dexamethasone and etoposide for hemophagocytic lymphohistiocytosis treatment, while one received dexamethasone alone. All four patients died.ConclusionsCases of hemophagocytic lymphohistiocytosis associated with Kaposi sarcoma and AIDS are rare in the literature. In conclusion, high fever may appear in the early stages of Kaposi sarcoma in people living with HIV and AIDS. Since hemophagocytic lymphohistiocytosis has a high mortality rate, early diagnosis and prompt initiation of appropriate treatment are crucial.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251355834"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"HIV prevalence and associated risk factors among people who inject drugs in four states of central India: Findings from the 17th round of HIV sentinel surveillance.","authors":"Shreya Jha, Nishakar Thakur, Lukram Slim, Sanjay Rai, Pradeep Kumar, Puneet Misra, Rakesh Kumar, Partha Haldar, Chinmoyee Das","doi":"10.1177/09564624251355835","DOIUrl":"https://doi.org/10.1177/09564624251355835","url":null,"abstract":"<p><p>BackgroundThis study was conducted to assess the prevalence of HIV and its associated risk factors among people who inject drugs in the four states of Central Zone of India (Bihar, Delhi, Uttar Pradesh and Uttarakhand), based on the data collected during the 17th round of HIV Sentinel Surveillance (HSS) during January to March, 2020.MethodsThe data was used from the 17th round of HSS which was collected through a paper-based survey among participants who were identified as people who inject drugs (PWIDs), followed by blood sample collection. Random sampling method was used to identify 250 PWIDs from each sentinel site.ResultsThe key demographic findings show that 60.1% of the participants were of age >=30 years and primarily urban residents (84.5%). Most participants have been tested for HIV previously (97.5%). With almost two-thirds of the participants injecting drugs daily, 89.5% of them reported to have used sterile needles each time. One-third of the participants had avoided health care services due to stigma and discrimination and they are significantly at higher odds of being HIV seropositive (1.83 times).ConclusionsThe study highlights the risk behaviour association with higher odds of being HIV seropositive were high risk occupation, sharing of needles, PWIDs on OST therapy, HIV testing and avoidance of healthcare services - due to stigma. Better programmatic approach is needed to protect the PWIDs.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251355835"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suneeta Soni, Helen Fifer, Yaser Al-Shakarchi, Joanne Bassett, Joy Mbaulu, Nicolas Pinto-Sander, Sara Strodtbeck, Michael Rayment
{"title":"British Association of Sexual Health and HIV National guideline for the management of infection with <i>Mycoplasma genitalium,</i> 2025.","authors":"Suneeta Soni, Helen Fifer, Yaser Al-Shakarchi, Joanne Bassett, Joy Mbaulu, Nicolas Pinto-Sander, Sara Strodtbeck, Michael Rayment","doi":"10.1177/09564624251359054","DOIUrl":"10.1177/09564624251359054","url":null,"abstract":"<p><p>This guideline provides details on the pathology and clinical features of <i>Mycoplasma genitalium</i> infection and makes recommendations for diagnostic tests, treatment regimens and the health promotion principles needed for the effective management of infection, in people aged 16 years or older attending sexual health services. The guideline is primarily aimed at level 3 sexual health services in the UK, although it could also serve as a reference guide for sexually transmitted infections services at other levels. It is updated from the previous guideline published in 2018.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251359054"},"PeriodicalIF":1.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vanbaelen Thibaut, Sheeba Manoharan-Basil, Kenyon Chris
{"title":"Number of chlamydia diagnoses per capita not associated with rates of ectopic pregnancies and female infertility - An ecological study.","authors":"Vanbaelen Thibaut, Sheeba Manoharan-Basil, Kenyon Chris","doi":"10.1177/09564624251361294","DOIUrl":"https://doi.org/10.1177/09564624251361294","url":null,"abstract":"<p><p>BackgroundTubal infertility and ectopic pregnancies are serious, but rare, complications of chlamydia infections. It is unclear whether chlamydia screening in women has an impact on these complications. Chlamydia incidence rates between European countries vary by orders of magnitude, which largely reflects different intensities of screening.MethodsWe used chlamydia diagnoses rates as a proxy for chlamydia screening rates to assess if differences in screening intensity were associated with differences in the frequency of ectopic pregnancy and the prevalence of infertility in women. We used mixed effects linear regression to assess for an association between chlamydia screening intensity in European countries and two outcomes: (1) the incidence of ectopic pregnancy and (2) the prevalence of infertility in women, while controlling for year, income and quality of health services.ResultsThe number of countries with available data increased from 3 in 1990 to 23 in 2019, before slightly declining to 22 in 2020. CT incidence varied across countries, from a median of 207 cases per 100,000 in 1990 (IQR: 59-313) to 33 cases per 100,000 in 2021 (IQR: 3-179). There was less variation in ectopic pregnancy incidence (median: 208 and 33 per 100,000 in 1990 and 2021, respectively), and female infertility prevalence (median 1,224 and 1,587 per 100,000 in 1990 and 2021, respectively). No association was found between screening intensity and ectopic pregnancy incidence or infertility prevalence after adjusting for year, GDP per capita, and universal health coverage index.ConclusionsOur results are compatible with other types of data that suggest that the intensity of screening for chlamydia is not associated with a large effect on the population-level frequency of all ectopic pregnancies and female infertility.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251361294"},"PeriodicalIF":1.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}