International Journal of STD & AIDS最新文献_第8页

Implementation of a multidisciplinary approach to care for people with HIV aged 80 years and over. 对 80 岁及以上的艾滋病毒感染者实施多学科护理方法。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-01-01 Epub Date: 2024-09-30 DOI: 10.1177/09564624241286558

Maithili Varadarajan, Sophie Blackburn, Nicolo Girometti, Alexandra Hicks, Elizabeth Senkoro, Caterina Candela, Elizabeth Ridsdill Smith, Nadia Naous, Timothy Tong, Marta Boffito

{"title":"Implementation of a multidisciplinary approach to care for people with HIV aged 80 years and over.","authors":"Maithili Varadarajan, Sophie Blackburn, Nicolo Girometti, Alexandra Hicks, Elizabeth Senkoro, Caterina Candela, Elizabeth Ridsdill Smith, Nadia Naous, Timothy Tong, Marta Boffito","doi":"10.1177/09564624241286558","DOIUrl":"10.1177/09564624241286558","url":null,"abstract":"Background: Frailty adversely affects health and quality of life of people with HIV (PWH). A multidisciplinary-team (MDT) was established to perform a Comprehensive Geriatric Assessment (CGA) and to address modifiable risk factors in elderly PWH.Methods: PWH aged over 80 years were reviewed by a dedicated HIV/geriatric clinic at Chelsea and Westminster Hospital. Descriptive statistics were used to report the variables of interest.Results: Sixty-three PWH were reviewed, with a median age of 82 (IQR 80-86). Fifty-seven (88%) were men. The median number of co-morbidities was five (IQR 4-7) and polypharmacy was seen in 55 (85%), with a median of six (IQR 5-8) co-medications reported. The median Rockwood Clinical Frailty Score was two (IQR 2-5). Antiretrovirals were modernised in 18 (29%) individuals; co-medication changes and de-prescribing was recommended in 39 (62%).Conclusion: A MDT approach helped reducing polypharmacy and frailty, suggesting that specialised tools and MDT input are key to identify medical and social concerns in elderly PWH.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"65-71"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of non-alcoholic fatty liver disease in antiretroviral therapy-naïve people with human immunodeficiency virus who start DTG/ABC/3TC compared to BIC/FTC/TAF at 48-week follow-up. 开始接受 DTG/ABC/3TC 与 BIC/FTC/TAF 抗逆转录病毒治疗的人类免疫缺陷病毒感染者在 48 周随访期间的非酒精性脂肪肝发病率比较。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-01-01 Epub Date: 2024-09-27 DOI: 10.1177/09564624241287886

Ana Luz Cano Díaz, Salma Triana González, Gloria Elizabeth Salinas Velázquez, José Antonio Mata Marín, Jesús Enrique Gaytán Martínez, Stefan Mauss

{"title":"Incidence of non-alcoholic fatty liver disease in antiretroviral therapy-naïve people with human immunodeficiency virus who start DTG/ABC/3TC compared to BIC/FTC/TAF at 48-week follow-up.","authors":"Ana Luz Cano Díaz, Salma Triana González, Gloria Elizabeth Salinas Velázquez, José Antonio Mata Marín, Jesús Enrique Gaytán Martínez, Stefan Mauss","doi":"10.1177/09564624241287886","DOIUrl":"10.1177/09564624241287886","url":null,"abstract":"Purpose: To determine the incidence of non-alcoholic fatty liver disease (NAFLD) by non-invasive methods in people living with HIV (PLWH).Methods: Prospective cohort, in PLWH naïve to antiretroviral therapy, starting bictegravir (BIC) or dolutegravir (DTG) at the Hospital de Infectología \"La Raza\", in Mexico City, from February 2021 to August 2023. We measured at baseline and 48 weeks triglycerides and glucose index (TyG), fatty liver index (FLI), hepatic steatosis index (HSI) and liver ultrasonography; relative risk (RR) for developing NAFLD was determined.Results: At 48 weeks, TyG index in BIC-group 4.54 (IQR 4.36-4.75), in DTG-group 4.66 (IQR 4.49-4.80), p = .080; HSI in BIC-group 30.30 (IQR 28.12-33.70), in DTG-group 30.85 (IQR 28.02-34.50), p = .650; FLI in BIC-group 14.88 (IQR 7.91-31.80), in DTG-group 19.49 (IQR 8.49-32.28), p = .729; NAFLD was detected by US in 6 [10.3% (95%CI 4.8%-20.7%)] in BIC-group and, 7 [10.9% (95%CI 6.4%-20.9%)] in DTG-group, p = .916. Risk factors for NAFLD development were baseline BMI ≥25 kg/m2, baseline HDL-c <40 mg/dL, and FIB-4 >1.3 at 48 weeks.Conclusion: There is a high incidence of NAFLD in PLWH who start a second generation INSTI at 48 weeks; baseline overweight, low HDL-cholesterol and FIB-4 >1.3 at 48 weeks of treatment were independent risk factors for NAFLD development.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"36-41"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Game of clades: A global mpox snapshot. 支系游戏：全球 mpox 快照。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-01-01 Epub Date: 2024-09-26 DOI: 10.1177/09564624241288279

Muhammad Abbas Abid

引用次数: 0

Lipschütz ulcers: A diagnosis to be considered in the post-COVID-19 era. Lipschütz溃疡：后 COVID-19 时代需要考虑的诊断。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-01-01 Epub Date: 2024-10-03 DOI: 10.1177/09564624241289993

Rodríguez-Hernández Fernando Daniel, Pérez-Cavazos Samantha, Camacho-Ortiz Adrián, Treviño-Salinas Emilio Modesto, Pérez-Barragán Edgar

引用次数: 0

Clinical characteristics and mortality of tuberculosis among adults living with HIV/AIDS: A single center, retrospective cohort study in Thailand. 感染艾滋病毒/艾滋病的成年人中结核病的临床特征和死亡率：泰国单中心回顾性队列研究。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-01-01 Epub Date: 2024-10-03 DOI: 10.1177/09564624241289986

Hariwong Chaicharoen, Sethapong Lertsakulbunlue, Boonsub Sakboonyarat, Worapong Nasomsong

{"title":"Clinical characteristics and mortality of tuberculosis among adults living with HIV/AIDS: A single center, retrospective cohort study in Thailand.","authors":"Hariwong Chaicharoen, Sethapong Lertsakulbunlue, Boonsub Sakboonyarat, Worapong Nasomsong","doi":"10.1177/09564624241289986","DOIUrl":"10.1177/09564624241289986","url":null,"abstract":"Background: Tuberculosis (TB) among people living with HIV/AIDS (PLWHA) contributes substantially to morbidity and mortality, particularly in high TB burden countries. Our objective is to investigate the clinical characteristics and mortality rates associated with TB among adult PLWHA over a 10-year period at an urban HIV clinic situated in a high TB burden country.Method: A retrospective cohort study was conducted in 2022. The primary endpoints were clinical characteristics and mortality rate of TB, determined as per 100 person-years among adult PLWHA, presented with a 95% confidence interval. Univariable and multivariable Cox proportional regression analyses were performed to determine risk factors for TB mortality.Result: From January 2012-December 2022, 155 PLWHA receiving a diagnosis of TB were enrolled. The median age was 29 (26.5-48.5) years, and the median CD4 + T cell count was 141 (41.8-252.8) cells/µL, with 60.0% of patients with TB manifesting as disseminated infection. The most involved organs were pulmonary (89.7%), lymph nodes (39.4%) and pleura (14.8%). The treatment outcomes exhibited success in 63.2% of cases, relapse in 5.2%, loss to follow up in 17.4% and death in 14.2%. The overall mortality rate was 18.8 per 100 person-years. Multivariable analyses showed significant factors affecting mortality, including lymph node involvement (adjusted HR 3.5; 95% CI 1.1-10.8) and thrombocytopenia (adjusted HR 74.2; 95% CI 10.0-551.4).Conclusion: TB in PLWHA, commonly presenting as disseminated infection, contributes to high mortality. Lymph node involvement and thrombocytopenia are significant factors contributing to mortality. Tuberculosis preventive treatment should be considered for improved prevention strategies among PLWHA, particularly in high TB burden countries.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"56-64"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexual and domestic violence enquiry: A national exploratory survey of asking and telling in sexual health services in the UK. 性暴力和家庭暴力调查：对英国性健康服务中的询问和倾诉进行全国性探索调查。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-01-01 Epub Date: 2024-09-26 DOI: 10.1177/09564624241286926

Jane Meyrick, Amy Bennett, Kyle McGovern, Charlotte Kite

{"title":"Sexual and domestic violence enquiry: A national exploratory survey of asking and telling in sexual health services in the UK.","authors":"Jane Meyrick, Amy Bennett, Kyle McGovern, Charlotte Kite","doi":"10.1177/09564624241286926","DOIUrl":"10.1177/09564624241286926","url":null,"abstract":"Background: Gender-based violence in the form of domestic and sexual abuse represent a worldwide public health and civil rights issue. Healthcare and sexual health have a central role to play in prevention, particularly in the identification of sexual and domestic violence/abuse within a frontline service in which it often presents. Survivors of sexual violence and abuse commonly pass through sexual health services without being asked about their victimisation. Healthcare should be able to identify survivors, provide first line support, refer to specialist services and link to comprehensive post assault care.Methods: In the first joint study of its kind, the Univeristy of the West of England worked with the British Association for Sexual Health and HIV (BASHH) and their Sexual Violence Specialist Interest Group (SVSIG). We report the findings of a snapshot, non-probability, exploratory survey of current comparative sexual and domestic violence/abuse enquiry practice in Genito Urinary Medicine services across the UK.Results: Sixty-two responding services evidenced variable practice around asking, collating data, referral, training and staff supervision.Conclusions: This benchmarking study of practice in the UK sets a bar against which all services can measure and improve current practice on gender-based violence identification, a crucial role of sexual health services in reducing the inequalities driven harm of undisclosed trauma.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"42-46"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Joint British Association for Sexual Health and HIV and Royal College of Obstetricians and Gynaecologists national UK guideline for the management of herpes simplex virus (HSV) in pregnancy and the neonate (2024 update). 英国性健康与艾滋病协会和英国皇家妇产科医学院联合制定的英国国家妊娠期和新生儿单纯疱疹病毒 (HSV) 管理指南（2024 年更新）。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-01-01 Epub Date: 2024-09-30 DOI: 10.1177/09564624241280734

Emily Clarke, Raj Patel, Dyan Dickins, Katy Fidler, Allan Jackson, Margaret Kingston, Christine Jones, Hermione Lyall, Marian Nicholson, Emanuela Pelosi, David Porter, Gemma Powell, Elizabeth Foley

引用次数: 0

Characterizing long-acting injectable antiretroviral therapy eligibility and initiation at a safety net academic medical center in the southeastern United States. 美国东南部一家安全网学术医疗中心的长效注射抗逆转录病毒疗法资格和启动特点。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-01-01 Epub Date: 2024-10-03 DOI: 10.1177/09564624241289998

Sarah E Rutstein, Christopher Lopez, Thibaut Davy-Mendez, Harsh Agarwal, Hanna Huffstetler, Angela Perhac, Barbarajean Turner, Joseph J Eron, Vivian Go, Claire E Farel, Kuo-Ping Li, Sonia Napravnik

{"title":"Characterizing long-acting injectable antiretroviral therapy eligibility and initiation at a safety net academic medical center in the southeastern United States.","authors":"Sarah E Rutstein, Christopher Lopez, Thibaut Davy-Mendez, Harsh Agarwal, Hanna Huffstetler, Angela Perhac, Barbarajean Turner, Joseph J Eron, Vivian Go, Claire E Farel, Kuo-Ping Li, Sonia Napravnik","doi":"10.1177/09564624241289998","DOIUrl":"10.1177/09564624241289998","url":null,"abstract":"Background: Long-acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) extends dosing intervals from daily to every 8 weeks. Equitable implementation requires anticipating and addressing barriers to use. We described LAI-CAB/RPV eligibility and initiation among persons with HIV (PWH) receiving care at a Southeastern US academic medical center. Methods: We included PWH ≥18 years, in care 01/01/2020-12/31/2021, and participating in the UNC CFAR HIV Clinical Cohort. We characterized LAI-CAB/RPV eligibility, compared those with and without recent detectable viral load (VL), and described clinical outcomes on LAI-CAB/RPV. Results: Among 1672 PWH, 425 (25.4%) had LAI-CAB/RPV drug-resistance. Among 1238 LAI-eligible PWH, 8.9% had detectable VL. Median age was 53 (interquartile range 40, 61), 54.6% were non-Hispanic Black, and 73.6% male. Over one-third lived >50 miles from clinic, one-fifth were uninsured, and 7.4% reported hazardous alcohol use. Gaps in care (prior 12-month) were more common among PWH with detectable VL versus suppressed (23.1% vs 13.9%, p = 0.03). 6/47 initiated LAI-CAB/RPV had detectable VL prior to injection; >95% sustained suppression and those with detectable VL had a rapid decline in viremia. Conclusions: Three-quarters of PWH were eligible for LAI-CAB/RPV, but equitable implementation may require addressing challenges such as distance to care, inconsistent care engagement, and other comorbid conditions, particularly for PWH with viremia.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"47-55"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated IL-10 serum levels are associated with slower serological response following syphilis treatment during pregnancy. 妊娠期梅毒治疗后血清IL-10水平升高与血清学反应减慢有关。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-12-03 DOI: 10.1177/09564624241303816

Martyna Kiolbasa, Agnieszka Kotlarz, Konrad Kaminiów, Maciej Pastuszczak

{"title":"Elevated IL-10 serum levels are associated with slower serological response following syphilis treatment during pregnancy.","authors":"Martyna Kiolbasa, Agnieszka Kotlarz, Konrad Kaminiów, Maciej Pastuszczak","doi":"10.1177/09564624241303816","DOIUrl":"10.1177/09564624241303816","url":null,"abstract":"Background: Approximately 50% of pregnant individuals treated for syphilis do not achieve a decline in non-treponemal titers by delivery. The serological response in pregnant persons is significantly slower compared to non-pregnant individuals, with unclear pathogenesis and clinical significance. This study aimed to determine the association between the host immune response and serological outcome in pregnant individuals with syphilis.Methods: Twenty-four females with early syphilis, including 14 pregnant individuals, were included. Pro-inflammatory and regulatory cytokines (IFN-γ, TNF-α, IL-4, IL-1β, IL-10, TGF-β) were measured before treatment and 6 months after penicillin injection.Results: The median time to serological cure was 5 months for pregnant individuals and 2 months for non-pregnant females. Pregnant individuals had significantly higher serum levels of IL-10 and TGF-β at baseline and at 6 months post-treatment compared to non-pregnant individuals (p < .05).Conclusions: A robust regulatory immune response to syphilis may be associated with a slower serological response to therapy during pregnancy.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241303816"},"PeriodicalIF":1.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"How well do we know our patients?": Further validation of a complexity rating scale for HIV. "我们对病人了解多少？进一步验证艾滋病复杂性评分量表。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-12-01 Epub Date: 2024-09-02 DOI: 10.1177/09564624241279604

Kim Begley, Don Smith, Handan Wand, Derek Chan, Virginia Furner, Melissa Louise Kelly, Patrick McGrath, Ruth Hennessy, Anthony Price, Lia Purnomo, Bruce Hamish Bowden, Shiraze M Bulsara

{"title":"\"How well do we know our patients?\": Further validation of a complexity rating scale for HIV.","authors":"Kim Begley, Don Smith, Handan Wand, Derek Chan, Virginia Furner, Melissa Louise Kelly, Patrick McGrath, Ruth Hennessy, Anthony Price, Lia Purnomo, Bruce Hamish Bowden, Shiraze M Bulsara","doi":"10.1177/09564624241279604","DOIUrl":"10.1177/09564624241279604","url":null,"abstract":"Background: Despite advances in the management and treatment of HIV, identifying risks for disengagement are essential to maximize positive outcomes. The current study investigated the validity of the Clinical Complexity Rating Scale for HIV (CCRS-HIV), a risk-prediction tool, by assessing agreement between patient and clinician scores of patient complexity.Methods: 207 patients completed the patient version of the CCRS-HIV (CCRS-HIVP), and six Attending Medical Officers (AMOs) caring for those individuals completed the original clinician version (CCRS-HIVC). Kappa statistics, sensitivity and specificity were used to assess patient-clinician agreement.Results: Patient-clinician agreement was highest for problematic crystal methamphetamine use (86%), polypharmacy (84%) and other physical health concerns (67%). Cut-offs of 40 and 45 for the total CCRS-HIV score were identified as most appropriate, with high sensitivity (79.31% and 76.0% respectively).Conclusions: Overall agreement between the clinician and patient complexity scores was high. These findings provide further evidence of the validity of the scale. The study demonstrates that the unique role of AMOs at the center contributes to them knowing their patients well, allowing them to manage and refer when required for interdisciplinary care which likely contributes to their ongoing engagement in care and may account for the high level of agreement.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1112-1119"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0