International Journal of STD & AIDS最新文献

{"title":"Acceptability and feasibility of HIV pre-exposure prophylaxis (PrEP) in Southeast Asia: A scoping review.","authors":"Justitia Roma Espera, Chaia Alyssa Reyes, Erla Grace Sarmiento, Czarina Mae Sitchon, Roueline Zantua, Rogie Royce Carandang","doi":"10.1177/09564624241306158","DOIUrl":"10.1177/09564624241306158","url":null,"abstract":"<p><strong>Background: </strong>The availability of HIV pre-exposure prophylaxis (PrEP) in Southeast Asia remains limited compared to regions like Western Europe or North America. Additionally, little is known about how key populations in Southeast Asia perceive the use of PrEP as a prevention tool for HIV. This scoping review aims to provide an overview of the literature on the acceptability and feasibility of HIV PrEP programs in Southeast Asia.</p><p><strong>Methods: </strong>We conducted a systematic search using nine electronic databases, gray literature searches, and hand searches of references in included full-text articles. Following PRISMA guidelines for scoping reviews, we focused on original research articles published in English from July 2012 to December 2022. A narrative synthesis was used to summarize the findings.</p><p><strong>Results: </strong>We identified 8,871 articles through the database search, removed 1,094 duplicates, and excluded 7,745 articles after title and abstract screening. Over 28 articles met the inclusion criteria. The use of PrEP was found to be highly acceptable, with participants showing a willingness to use and pay for it, moderate usage rates, convenience, and preference over other prevention methods. It was also considered highly feasible due to its effectiveness and successful program implementation. However, barriers included risk compensation, concerns about side effects, the burden of daily pill administration, and, most commonly noted in studies, cost.</p><p><strong>Conclusion: </strong>HIV PrEP has been shown to be both acceptable and feasible. The necessity for direct efforts to expand PrEP access in Southeast Asia and address barriers to its uptake and adherence underscores the importance of ongoing monitoring and implementation.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"260-274"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of acquired syphilis in an infant through mouth-to-mouth transmission of prechewed food.","authors":"Sen Feng, Qing Zhu, Mingyuan Ren, Guoying Miao, Guoqiang Zhang","doi":"10.1177/09564624241312950","DOIUrl":"10.1177/09564624241312950","url":null,"abstract":"<p><strong>Background: </strong>Patients with syphilis are the only source of infection, which can be transmitted through sexual contact and mother-to-child and blood transmission, and rarely through contaminants. The clinical manifestations of syphilis are complex and variable, and can be easily misdiagnosed. This article reports a case of syphilis in a child with \"psoriasis\"-like lesions who was fed pre-chewed food.</p><p><strong>Case presentation: </strong>An 18-month-old girl presented with mung bean to peanut-sized erythema and papules scattered on both lower limbs and perianal area; some of the erythema was covered with scales, with clear boundaries and no fusion. The case was misdiagnosed as \"psoriasis\" in the local hospital until the child and her mother tested positive for syphilis in the outpatient clinic of our hospital. The girl's mother had a habit of chewing food in her mouth before feeding it to her child.</p><p><strong>Conclusions: </strong>Consumption of food chewed by a person with syphilis can lead to infection, and attention should be paid to the possible ways and means of being infected.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"334-336"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, knowledge and readiness of clinicians to deliver 4CMenB vaccines for <i>Neisseria gonorrhoeae</i> prevention.","authors":"Lucy Rabuszko, Sarah Stuart-George, Deborah Williams, Daniel Richardson","doi":"10.1177/09564624241306157","DOIUrl":"10.1177/09564624241306157","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"255-256"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence of HPV in cervical smears of vaccinated WLWH support for combined molecular testing and cytology screening.","authors":"Milena Siqueira Pereira, Silvia Maria Baeta Cavalcanti, Charbell Miguel Haddad Kury, Willker Menezes da Rocha, Rafael Brandão Varella","doi":"10.1177/09564624241310947","DOIUrl":"10.1177/09564624241310947","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) infection profoundly affects women living with HIV (WLWH). This infection leads to cervical cancer (CC) and increased mortality.</p><p><strong>Methods: </strong>This study monitored HPV infection in WLWH in Rio de Janeiro, Brazil, before (T1) and after (T2) 4 years of vaccination. HPV genotyping and the presence of intraepithelial lesions were investigated at both time points.</p><p><strong>Results: </strong>Among the 156 WLWH who received the quadrivalent HPV vaccine (4vHPV) at T1, 30 (19.2%) were initially found to have HPV DNA. After vaccination, only three (7%) of those who were HPV-negative at T1 tested positive for HPV. Most women who tested positive for HPV DNA at T1 had normal Pap smear results. However, this cohort also demonstrated a significant increase in cases of atypical squamous cells of uncertain significance and cervical intraepithelial neoplasia in PCR-negative HPV DNA samples at T2 (<i>p</i> < .01). Conversely, women who initially tested negative for HPV DNA continued to exhibit normal Pap smear results in 2018 (<i>p</i> < .01).</p><p><strong>Conclusions: </strong>This study highlights the persistence of HPV in WLWH despite vaccination and underscores the importance of continued molecular and cytologic screening. The findings enhance our understanding of vaccine effectiveness in this population and emphasize the need for tailored preventive strategies.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"304-308"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Admission diagnoses and outcomes among hospitalized people living with HIV during pre-COVID-19, COVID-19 and post-COVID-19 pandemic periods.","authors":"Pattarapoom Panutat, Thana Khawcharoenporn","doi":"10.1177/09564624241304849","DOIUrl":"10.1177/09564624241304849","url":null,"abstract":"<p><strong>Background: </strong>Data on the impact of coronavirus disease 2019 (COVID-19) on hospitalization and outcomes among people living with HIV (PLHIV) are limited.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted among PLHIV hospitalized during the pre-COVID-19, COVID-19, and post-COVID-19 periods.</p><p><strong>Results: </strong>Of the 310 PLHIV included, 117, 125 and 68 were admitted during the three periods, respectively and 115 (37%) were newly diagnosed with HIV. Median CD4 cell counts and proportions of those with antiretroviral therapy (ART) adherence rates ≥95% at admission were different between the three periods [(206, 97 and 138 cells/mm³ (<i>p</i> = .02) and 97%, 89% and 100% (<i>p</i> = .06), respectively]. Of the 310 PLHIV, admission diagnoses were non-AIDS-related (62%) and AIDS-related (38%). Most of the non-AIDS-related diagnoses were infections other than opportunistic infections (OIs) (40%) while OIs were the most common for AIDS-related diagnoses (88%). The types of admission diagnoses were comparable between the three periods. Hospital mortality rates were 10%, 13% and 16% during pre-COVID-19, COVID-19 and post-COVID-19 periods, respectively (<i>p</i> = .80). By multivariable analysis, intensive care unit admission, underlying malignancy, monthly income less than $USD 400, and admission CD4 less than 50 cells/mm³ were independently associated with hospital mortality.</p><p><strong>Conclusions: </strong>Although admission during COVID-19 pandemic period was not associated with increased mortality, we observed the impact of the pandemic on the lower CD4 cell count and ART adherence at admission among hospitalized PLHIV. Interventions to improve early care engagement, ART adherence, and close monitoring for those with identified mortality risks are needed for better HIV care, especially during pandemics.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"231-240"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HI Acquired palmoplantar keratoderma in an immunocompromised patient: A case report.","authors":"Daniel Z Villarreal-Martínez, Mayra A Reyes-Soto, Leslie M Garza-García, Jair A Valdez-Zertuche, Daniela López-Quintero, Sonia Chavez-Alvarez, Jorge Ocampo-Candiani, Alejandra Villarreal-Martínez","doi":"10.1177/09564624241307732","DOIUrl":"10.1177/09564624241307732","url":null,"abstract":"<p><p>Syphilis, known for its capacity to mimic various diseases, has seen rising incidence, particularly in adolescents, men who have sex with men (MSM), and individuals with HIV. Palmoplantar keratoderma (PPK), a rare manifestation of secondary syphilis, poses diagnostic challenges due to its resemblance to other conditions. We report the case of a 42-year-old man living with HIV presenting with acquired PPK, characterized by hyperkeratotic plaques on the palms and soles, alongside syphilitic roseola. Histopathology confirmed psoriasiform dermatitis with spirochetes. The patient received weekly intramuscular benzathine penicillin G, leading to significant clinical improvement without relapse. This case underscores the importance of recognizing atypical infectious presentations in individuals living with HIV and highlights the need for careful differential diagnosis in acquired PPK cases.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"246-249"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The challenges in lymphogranuloma venereum diagnosis whether NAAT is negative, a case series.","authors":"Igor Malec, Robin Vanstokstraeten, Eveline Van Honacker, Pierre Lefesvre, Dunja Wilmes, Kathleen Van Damme, Marco Moretti","doi":"10.1177/09564624241307733","DOIUrl":"10.1177/09564624241307733","url":null,"abstract":"<p><strong>Background: </strong>Persistent inguinal lymphadenopathy can range from benign to malignant causes. Lymphogranuloma venereum (LGV), a sexually transmitted infection (STI), is a possible cause, particularly in individuals engaged in sexual practices associated with a higher likelihood of transmitting STIs. This case series outlines the diagnostic challenges of LGV.</p><p><strong>Case presentation: </strong>Two male patients, aged 36 and 48, with sexual practices associated with an elevated risk of STI transmission, presented with inguinal lymphadenopathy. Initial investigations, including rectal and genital nucleic acid amplification tests (NAATs) for STIs, were negative. Patient one underwent two fine-needle aspirations, both inconclusive. An excisional biopsy later confirmed LGV through a positive NAAT for <i>Chlamydia trachomatis</i> and consistent pathology. The diagnosis took several years, included three PET scans, and was complicated by a surgical site infection with <i>Staphylococcus aureus</i>. Patient 2, despite negative NAAT results, was empirically treated for LGV based on clinical suspicion, with resolution after doxycycline.</p><p><strong>Intervention and outcome: </strong>Both patients improved significantly with doxycycline. Retrospective serology showed elevated <i>Chlamydia trachomatis</i> IgG titers, supporting this diagnosis.</p><p><strong>Conclusion: </strong>This case series emphasizes the need to consider LGV in patients with persistent lymphadenopathy and sexual practices that may increase the likelihood of STIs.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"283-288"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal <i>Escherichia coli</i> in men who have sex with men: A systematic review.","authors":"Jim Abi Frem, Annie Russell, Colin Fitzpatrick, Deborah Williams, Daniel Richardson","doi":"10.1177/09564624241306847","DOIUrl":"10.1177/09564624241306847","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review aimed to explore any demographic, biological and behavioural characteristics of men who have sex with men (MSM) with diarrhoeagenic <i>E.coli</i>.</p><p><strong>Design/methods: </strong>We searched MEDLINE, EMBASE, and CINAHL for manuscripts published to March 2024. One author screened manuscript abstracts; two authors independently conducted a full text review. We only included primary data on gastrointestinal <i>E.coli</i> in MSM. Risk of bias was assessed independently by two authors using the Joanna Briggs Institute tools. This review was registered on PROSPERO(CRD42023455321).</p><p><strong>Results: </strong>Eleven manuscripts (cross-sectional studies (<i>n</i> = 8), case-series (<i>n</i> = 1), case-control study (<i>n</i> = 1), longitudinal study (<i>n</i> = 1)) from Europe (<i>n</i> = 7) Australia (<i>n</i> = 2), USA (<i>n</i> = 2) including 983 MSM with gastrointestinal <i>E.coli</i> published between 2014-2023 were included in this review. Demographic factors (living with HIV, using HIV-PrEP, using dating apps and working as airline crew, group sex, non-regular (casual) sexual partners); behavioural factors (non-regular sexual partners, non-condom use, oro-anal sex, penile-anal sex, use of sex toys, insertive and receptive fisting, scat play); and infection factors (co-infection with <i>Chlamydia trachomatis</i> including LGV, <i>Neisseria gonorrhoeae</i>, <i>Treponema pallidum</i>, hepatitis C, other enteric pathogens [<i>Shigella</i> spp. <i>Giardia duodenalis, Entamoeba histolytica</i>, hepatitis A and intestinal spirochaetosis]) were observed in MSM with <i>E. coli</i>. Antimicrobial resistance (extended spectrum beta-lactamase and quinolone resistance) was described in MSM with <i>E.coli</i>.</p><p><strong>Conclusion: </strong>We have highlighted demographic, behavioral and infection factors observed in MSM with <i>E.coli</i> suggesting sexual transmissibility. These data provide insight for future clinical guidelines, public health control strategies and research.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"176-184"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging sexually transmitted infections outbreak: Dermatophytosis among men who have sex with men in Milan, Italy.","authors":"Chiara Maci, Angelo Roberto Raccagni, Riccardo Lolatto, Emanuela Messina, Diana Canetti, Chiara Tassan Din, Maria Del Carmen Garcia Martearena, Golnaz Torkjazi, Martina Bottanelli, Caterina Candela, Antonella Castagna, Silvia Nozza","doi":"10.1177/09564624241312731","DOIUrl":"10.1177/09564624241312731","url":null,"abstract":"<p><strong>Background: </strong>Dermatophytosis is an infection of the skin or adnexa, which is extremely widespread in the environment. Sexually transmitted infections (STIs) are an increasing global public health threat, especially among men who have sex with men (MSM). This study aims to describe an outbreak of sexually transmitted dermatophytosis among MSM in our cohort between April 2022 and October 2023.</p><p><strong>Methods: </strong>This is a retrospective monocentric study including outpatients who were diagnosed with at least one episode of dermatophytosis between March 2010 and October 2023 at the Infectious Diseases Unit of San Raffaele Scientific Institute, Milan, Italy. Mycosis diagnosis was mainly clinical following the medical visit and physical examination.</p><p><strong>Results: </strong>Overall, 107 people were diagnosed with dermatophytosis between March 2010 and October 2023. All 56 cases observed since April 2022 included 55 MSM and 1 female; compared to before 2022 there was a total diagnosis of 51 cases.</p><p><strong>Conclusions: </strong>These results highlight the evident increase in the incidence of mycotic infections among MSM, followed in our center. We are dealing with a new entity of sexually transmissible infections, in addition to the existing diseases that are being studied.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"319-323"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness, safety, and patient-reported outcomes of bictegravir/emtricitabine/tenofovir alafenamide in routine clinical care in Italy: 12-Month results from the BICSTaR cohort.","authors":"Andrea Antinori, Giulia Marchetti, Vincenzo Esposito, Stefano Rusconi, Diana Canetti, Eugenia Quiros-Roldan, Bianca Candelaresi, Annalisa Saracino, Massimo Andreoni, Andrea Marongiu, Tali Cassidy, David Thorpe, Laura Albini, Roberto Caldera, Gabriele Forcina, Giovanni Di Perri","doi":"10.1177/09564624241308372","DOIUrl":"10.1177/09564624241308372","url":null,"abstract":"<p><strong>Background: </strong>BICSTaR is a multi-national, observational cohort evaluating the effectiveness, safety, and patient-reported outcomes (PROs) in treatment-naïve (TN) and -experienced (TE) people with HIV-1 receiving bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in routine clinical care. We present the 12-month (M12) outcomes of the Italian BICSTaR cohort.</p><p><strong>Methods: </strong>Participants initiating B/F/TAF in routine care were prospectively followed. Outcomes included virological and immunologic effectiveness, drug-related adverse events (DRAEs), treatment persistence, and PROs using the HIV Symptom Index (HIV-SI) and the HIV Treatment Satisfaction Questionnaires (HIVTSQ).</p><p><strong>Results: </strong><i>N</i> = 201 were included (29 TN, 172 TE), 83% male, median age 38 years in TN, 48 years in TE. At baseline, 94% of TE had an HIV-1 RNA <50 cp/mL, 92% switched to B/F/TAF for simplification. Overall, 69% reported comorbidities (TN: 59%, TE: 70%). At M12, 88% (23/26) of TN and 96% (152/159) of TE had an HIV-1 RNA <50 cp/mL in the discontinuation = failure analysis (without emergence of resistance to B/F/TAF). Median CD4 count changes were +296 cells/µL (interquartile range [IQR], 118, 383) in TN, and +23 cells/µl (-137, 114) in TE. DRAEs were reported for 5% and led to discontinuation in 1%. M12 persistence on B/F/TAF was 97%. TN had a median HIV-SI bothersome symptom count decrease of -1.5 (IQR, -5.0, 0.0). Median treatment satisfaction change score was +29.0 (21, 30) in TE indicating an improvement.</p><p><strong>Conclusions: </strong>In this real-world Italian cohort of mostly treatment-experienced people switching for simplification, B/F/TAF demonstrated high effectiveness and persistence over 12 months and confirmed the favourable safety profile shown in clinical trials.</p><p><strong>Trial registration: </strong>European cohort: EUPAS22185.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"309-318"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}