International Journal of STD & AIDS最新文献_第10页

Elevated IL-10 serum levels are associated with slower serological response following syphilis treatment during pregnancy. 妊娠期梅毒治疗后血清IL-10水平升高与血清学反应减慢有关。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-12-03 DOI: 10.1177/09564624241303816

Martyna Kiolbasa, Agnieszka Kotlarz, Konrad Kaminiów, Maciej Pastuszczak

{"title":"Elevated IL-10 serum levels are associated with slower serological response following syphilis treatment during pregnancy.","authors":"Martyna Kiolbasa, Agnieszka Kotlarz, Konrad Kaminiów, Maciej Pastuszczak","doi":"10.1177/09564624241303816","DOIUrl":"10.1177/09564624241303816","url":null,"abstract":"Background: Approximately 50% of pregnant individuals treated for syphilis do not achieve a decline in non-treponemal titers by delivery. The serological response in pregnant persons is significantly slower compared to non-pregnant individuals, with unclear pathogenesis and clinical significance. This study aimed to determine the association between the host immune response and serological outcome in pregnant individuals with syphilis.Methods: Twenty-four females with early syphilis, including 14 pregnant individuals, were included. Pro-inflammatory and regulatory cytokines (IFN-γ, TNF-α, IL-4, IL-1β, IL-10, TGF-β) were measured before treatment and 6 months after penicillin injection.Results: The median time to serological cure was 5 months for pregnant individuals and 2 months for non-pregnant females. Pregnant individuals had significantly higher serum levels of IL-10 and TGF-β at baseline and at 6 months post-treatment compared to non-pregnant individuals (p < .05).Conclusions: A robust regulatory immune response to syphilis may be associated with a slower serological response to therapy during pregnancy.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241303816"},"PeriodicalIF":1.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"How well do we know our patients?": Further validation of a complexity rating scale for HIV. "我们对病人了解多少？进一步验证艾滋病复杂性评分量表。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-12-01 Epub Date: 2024-09-02 DOI: 10.1177/09564624241279604

Kim Begley, Don Smith, Handan Wand, Derek Chan, Virginia Furner, Melissa Louise Kelly, Patrick McGrath, Ruth Hennessy, Anthony Price, Lia Purnomo, Bruce Hamish Bowden, Shiraze M Bulsara

{"title":"\"How well do we know our patients?\": Further validation of a complexity rating scale for HIV.","authors":"Kim Begley, Don Smith, Handan Wand, Derek Chan, Virginia Furner, Melissa Louise Kelly, Patrick McGrath, Ruth Hennessy, Anthony Price, Lia Purnomo, Bruce Hamish Bowden, Shiraze M Bulsara","doi":"10.1177/09564624241279604","DOIUrl":"10.1177/09564624241279604","url":null,"abstract":"Background: Despite advances in the management and treatment of HIV, identifying risks for disengagement are essential to maximize positive outcomes. The current study investigated the validity of the Clinical Complexity Rating Scale for HIV (CCRS-HIV), a risk-prediction tool, by assessing agreement between patient and clinician scores of patient complexity.Methods: 207 patients completed the patient version of the CCRS-HIV (CCRS-HIVP), and six Attending Medical Officers (AMOs) caring for those individuals completed the original clinician version (CCRS-HIVC). Kappa statistics, sensitivity and specificity were used to assess patient-clinician agreement.Results: Patient-clinician agreement was highest for problematic crystal methamphetamine use (86%), polypharmacy (84%) and other physical health concerns (67%). Cut-offs of 40 and 45 for the total CCRS-HIV score were identified as most appropriate, with high sensitivity (79.31% and 76.0% respectively).Conclusions: Overall agreement between the clinician and patient complexity scores was high. These findings provide further evidence of the validity of the scale. The study demonstrates that the unique role of AMOs at the center contributes to them knowing their patients well, allowing them to manage and refer when required for interdisciplinary care which likely contributes to their ongoing engagement in care and may account for the high level of agreement.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1112-1119"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

British Association of Sexual Health and HIV (BASHH) UK guidelines for the management of syphilis in pregnancy and children 2024. 英国性健康与艾滋病协会（BASHH）《英国 2024 年妊娠与儿童梅毒管理指南》。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1177/09564624241280387

Margaret Kingston, Janet Wilson, Sarah Dermont, Helen Fifer, Koon Chan, Hermione Lyall, Paddy McMaster, Emma Shawkat, Alex Thomas-Leech

引用次数: 0

Introducing simulation-based education to Genitourinary Medicine specialty training in the North West of England: A quality improvement project exploring trainee perspectives and impact. 在英格兰西北部的泌尿生殖医学专业培训中引入模拟教学：探索学员观点和影响的质量改进项目。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI: 10.1177/09564624241280329

Izuchukwu Williams Ezeh

{"title":"Introducing simulation-based education to Genitourinary Medicine specialty training in the North West of England: A quality improvement project exploring trainee perspectives and impact.","authors":"Izuchukwu Williams Ezeh","doi":"10.1177/09564624241280329","DOIUrl":"10.1177/09564624241280329","url":null,"abstract":"Introduction: Simulation-based education (SBE) provides enactive experiences for learners. This project explores the utility of SBE in GUM training.Methods: Phase 1 was a qualitative survey of GUM trainees across the UK exploring their views on SBE. Phase 2 involved roll-out of SBE to new GUM trainees. Feedback was subsequently obtained.Results: Twenty-three participants were surveyed in phase 1. When asked to rate the relevance of SBE to curriculum competencies on a scale of 1 to 5 (1 = not relevant, 5 = highly relevant), the highest ratings (score ≥4) were for proctoscopy (4.1), IUD insertion (4.1), SDI removal (4.1), SDI insertion (4.0), and punch biopsy (4.0). All curriculum items scored ≥3. Eighty-three percent (n = 19) felt SBE will improve clinician confidence and competence. Following introduction of SBE, participants fed back on the relevance of the session. All 5 respondents rated the session ≥4 for addressing their clinical and curriculum goals. All respondents rated the session ≥4 for improving clinician confidence and competence. The session received an overall rating of 5, and respondents similarly rated 5 for more sessions.Conclusion: Trainees recognise the value of simulated learning experiences and its role in improving procedural competence and addressing bespoke human factor skills relevant to GUM.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1072-1074"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of STIs on cervical cancer screening: Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in visual inspection with acetic acid (VIA) positive women in Mozambique. 性传播感染对宫颈癌筛查的影响：莫桑比克乙酸肉眼检查（VIA）阳性妇女的沙眼衣原体和淋病奈瑟菌感染率。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI: 10.1177/09564624241272963

Alberto Sineque, Susanna Ceffa, Fernanda Parruque, Giovanni Guidotti, Cacilda Massango, Zita Sidumo, Carla Carrilho, Clara Bicho, Ricardina Rangeiro, Stefano Orlando, Cesaltina Lorenzoni, Fausto Ciccacci

{"title":"Impact of STIs on cervical cancer screening: Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in visual inspection with acetic acid (VIA) positive women in Mozambique.","authors":"Alberto Sineque, Susanna Ceffa, Fernanda Parruque, Giovanni Guidotti, Cacilda Massango, Zita Sidumo, Carla Carrilho, Clara Bicho, Ricardina Rangeiro, Stefano Orlando, Cesaltina Lorenzoni, Fausto Ciccacci","doi":"10.1177/09564624241272963","DOIUrl":"10.1177/09564624241272963","url":null,"abstract":"Background: Cervical cancer, primarily from HPV, is prevalent in countries like Mozambique, with HIV individuals at higher risk. The Visual Inspection with Acetic Acid (VIA) screening method can be influenced by STIs like Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). This study examines CT and NG prevalence in HIV-positive and negative women using VIA in Mozambique's DREAM program.Methods: In this cross-sectional research conducted at a DREAM program facility in Maputo from 01/07/2021 to 31/05/2022, cervical specimens were taken from VIA-positive patients. CT/NG testing was performed using the Cobas® 4800 DNA CT/NG test. Statistical analyses focused on associations and prevalence rates, considering demographic, clinical, and exposure data.Results: Among 117 women, we observed a CT prevalence of 6.8% (8/117) and an NG prevalence of 2.6%(3/117). No significant associations between CT/NG infection rates and factors such as age, HIV status, VIA results, or high-risk HPV (hrHPV) was observed. We found a 47% prevalence of hrHPV infections among participants with cervical lesions; no significant association between hrHPV and CT/NG infections was observed.Conclusion: This study highlights the prevalence of CT and NG in VIA-positive women in Mozambique, emphasizing the STI burden and suggesting integration of STI screening in cervical cancer prevention strategies.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1019-1024"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molluscum contagiosum is associated with atopic dermatitis and sexually transmitted infections in a matched case-control study using a national database. 在一项利用国家数据库进行的匹配病例对照研究中，传染性软疣与特应性皮炎和性传播感染有关。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1177/09564624241276571

Rachel C Hill, Aarushi K Parikh, Shari R Lipner

{"title":"Molluscum contagiosum is associated with atopic dermatitis and sexually transmitted infections in a matched case-control study using a national database.","authors":"Rachel C Hill, Aarushi K Parikh, Shari R Lipner","doi":"10.1177/09564624241276571","DOIUrl":"10.1177/09564624241276571","url":null,"abstract":"Background: Molluscum contagiosum (MC) is a poxvirus that manifests as firm, smooth, dome-shaped, umbilicated, flesh-colored papules. In adults, MC is commonly spread by sexual contact, and is self-limited in patients with intact immune systems but more widely distributed and difficult to treat in immunocompromised persons. We analyzed cases of adult MC for associations with immunosuppression, lifestyle risk factors, and sexually transmitted infections (STIs).Methods: Using the All of Us Research Program database, adults with MC were identified and matched with controls 1:10 based on demographic factors. Comorbidities, lifestyle risk factors, and medication exposures were analyzed. Odds ratios were calculated using logistic regression.Results: Our analysis included 146 cases of adults with MC and 1460 demographic-matched controls. Patients with MC were 48 years old on average, 59% female, and majority White (82.5%). Controls were similar for all demographic features. Adults with MC were more likely to have syphilis (odds ratio (OR) 16; 95% confidence interval (CI) 2.57-99.5), human immunodeficiency virus (HIV) (OR 9.54; 95% CI 3.95-23.0), chlamydia (OR 6.24; 95% CI 2.38-16.4), condyloma acuminata (OR 13.9; 95% CI 7.36-26.2), genital herpes (OR 4.13; 95% CI 1.87-9.15), or atopic dermatitis (AD) (OR 2.85; 95% CI 1.5-5.4) (all p < .01). There were no differences in prevalence of other comorbidities, lifestyle risk factors, nor medication exposures (all p > .05).Conclusions: We showed that adult MC is associated with AD and STIs, including HIV, chlamydia, condyloma acuminata, genital herpes, and syphilis. Sexually active adolescents and adults and those diagnosed with AD may be screened for MC and counseled on their potentially increased risk.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1050-1054"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The tale of two Badakhshans: Determinants of access and utilization of HIV preventive services along the Afghan-Tajik border. 两个巴达赫尚人的故事：阿富汗-塔吉克边境地区获得和利用艾滋病毒预防服务的决定因素。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-11-01 Epub Date: 2024-08-28 DOI: 10.1177/09564624241276904

Harsimren Sidhu, Frezghi Gebreweldi, Alissa Davis, Jonbek Jonbekov, Mahbat Bahramov, Anindita Dasgupta, Tara McCrimmon, Phillip Marotta, Kianoush Dehghani

{"title":"The tale of two Badakhshans: Determinants of access and utilization of HIV preventive services along the Afghan-Tajik border.","authors":"Harsimren Sidhu, Frezghi Gebreweldi, Alissa Davis, Jonbek Jonbekov, Mahbat Bahramov, Anindita Dasgupta, Tara McCrimmon, Phillip Marotta, Kianoush Dehghani","doi":"10.1177/09564624241276904","DOIUrl":"10.1177/09564624241276904","url":null,"abstract":"Background: Injection of opioids has contributed to growing HIV epidemics in Tajikistan and Afghanistan. This qualitative study explored determinants of access to primary prevention and screening for HIV among people who inject drugs (PWID) residing in border communities of Gorno-Badakhshan, Tajikistan and Badakhshan, Afghanistan.Methods: Semi-structured interviews were conducted with PWID, community leaders, and healthcare workers. The social-ecological model was used to inform a thematic analysis of determinants of access.Results: There were no preventive or screening services for HIV in the border districts of Afghanistan. Barriers to accessing HIV-related services in Tajikistan, and to accessing general health services in Afghanistan, included: lack of knowledge about HIV, inaccessible communities with poor infrastructure, discrimination and violence against women, and stigmatization of PWID and people living with HIV. Access to HIV-related and other health services by PWID was facilitated by community leader support, family support, outreach services, and linkage of harm reduction services with HIV testing and care.Conclusion: Urgent interventions are needed to stem the escalating HIV epidemic in Afghanistan and enhance existing services in Tajik border communities. This qualitative study offers insights into barriers and facilitators for accessing HIV prevention and screening services among PWID, suggesting potential interventions.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1025-1031"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11488286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful combination therapy of trichloroacetic acid, podophyllin, and electrocautery on giant condylomata acuminata. 三氯乙酸、荚叶素和电灼联合疗法成功治疗巨型尖锐湿疣。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-11-01 Epub Date: 2024-08-28 DOI: 10.1177/09564624241276574

Hasbiallah Yusuf, Muhammad Izazi Hari Purwoko

{"title":"Successful combination therapy of trichloroacetic acid, podophyllin, and electrocautery on giant condylomata acuminata.","authors":"Hasbiallah Yusuf, Muhammad Izazi Hari Purwoko","doi":"10.1177/09564624241276574","DOIUrl":"10.1177/09564624241276574","url":null,"abstract":"Introduction: Giant condylomata acuminata (GCA) is a rare presentation of anogenital wart (AGW), invasive locally but does not metastasize. Combination therapy for GCA is suggested based on modalities and experiences. The combination of TCA and podophyllin has showed good efficacy, followed by electrocautery to eradicate warts. Case: A 24-year-old male had a chief complaint of large warts on the base of the penis that had started to bleed for 4 weeks. The initial lesion appeared 8 months prior as a small varucose papule. The patient is unmarried and has history of sexual contact with sex workers. Physical examination showed multiple verrucous papules, flesh-coloured, cauliflower-like shaped, 5 × 2 × 1 cm in size. The patient tested negative for HIV infection. Histopathological examination showed acanthosis, exophytic growth, parakeratosis, and koilocytosis with no signs of malignancy. This patient received a combination of TCA 90% and podophyllin 25% to initially reduce the tumor size, followed by electrocautery to eradicate the remaining lesions. The tumor showed complete clearance. Discussion: There is no definitive evidence that one therapy is superior to completely eliminating warts. Combination therapy of TCA and podophyllin leads to complete wart clearance, followed by electrocautery to destroy smaller warts.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1079-1083"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatitis A vaccination in a racially and sexually diverse population of gay, bisexual, and other men who have sex with men: Findings from the QVax study. 在男同性恋、双性恋和其他男男性行为者等不同种族和性取向人群中接种甲型肝炎疫苗：QVax 研究结果。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-11-01 Epub Date: 2024-09-02 DOI: 10.1177/09564624241278765

Tiffany Y Guo, Perry N Halkitis, Kendra Lewis, Kristen D Krause

{"title":"Hepatitis A vaccination in a racially and sexually diverse population of gay, bisexual, and other men who have sex with men: Findings from the QVax study.","authors":"Tiffany Y Guo, Perry N Halkitis, Kendra Lewis, Kristen D Krause","doi":"10.1177/09564624241278765","DOIUrl":"10.1177/09564624241278765","url":null,"abstract":"Background: Previous studies found vaccination uptake of vaccine-preventable diseases (VPD) to be associated with race/ethnicity and medical mistrust among key populations, however, few studies examine Hepatitis A vaccination uptake.Methods: This cross-sectional study used online survey data collected from NJ and NY residents identifying as lesbian, gay, bisexual, transgender, queer (LGBTQ+) from October 2021 through November 2022.Results: This study used a subsample of 222 gay, bisexual, and other cisgender men, 66.7% White, with mean age 41.22 years (SD = 15.23), and 60% fully vaccinated for Hepatitis A. Overall, average group-based medical mistrust scores did not differ among non-vaccinated participants compared to fully or partially vaccinated participants. However, higher group-based medical mistrust scores were associated with non-White identifying participants, and were highest among Hispanic/Latinx (2.68, sd = 0.43) and Black non-Hispanic (2.58, sd = 0.50) participants (p < .001). Vaccination patterns did not differ among fear or vaccine confidence-based items.Conclusions: Our results contribute to the limited knowledge of differences in Hepatitis A vaccination uptake among men who have sex with men, and support the need for targeted intervention programs that acknowledge the diverse population of LGBTQ + identifying individuals and their associated health behaviors.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1032-1041"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical precancer and invasive cancer among women living with HIV in Latin America: A systematic review and meta-analysis. 拉丁美洲感染艾滋病毒妇女的宫颈癌前病变和浸润性癌症：系统回顾和荟萃分析。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-11-01 Epub Date: 2024-09-02 DOI: 10.1177/09564624241276577

Ginna Fernández-Deaza, Gabriela Negrete-Tobar, María Caicedo, Nicolás Téllez, Maeve B Mello, Massimo Ghidinelli, Bernardo Nuche-Berenguer, Raúl Murillo

{"title":"Cervical precancer and invasive cancer among women living with HIV in Latin America: A systematic review and meta-analysis.","authors":"Ginna Fernández-Deaza, Gabriela Negrete-Tobar, María Caicedo, Nicolás Téllez, Maeve B Mello, Massimo Ghidinelli, Bernardo Nuche-Berenguer, Raúl Murillo","doi":"10.1177/09564624241276577","DOIUrl":"10.1177/09564624241276577","url":null,"abstract":"Background: Data on the occurrence of cervical precancer and cancer among women living with HIV (WLHIV) in Latin American countries (LAC) are scarce and highly heterogeneous.Methods: We conducted a systematic review summarizing data about the incidence/prevalence of invasive cervical cancer (CC) and high-grade precancerous lesions among WLHIV in LAC. Literature in PubMed and LILACS was searched. The primary outcome was invasive cancer incidence, and prevalence of high-grade lesions as key indicators for the WHO CC elimination strategy. Individual reports on invasive cancer incidence and prevalence of precancerous lesions were obtained, and a random effects meta-analysis was conducted for the latter.Results: In total, 34,343 WLHIV from four studies reporting CC incidence in seven LAC were included, and 6079 WLHIV from 17 studies reporting prevalence of precancerous lesions in three LAC were included. CC incidence ranged between 136.0 and 398.4 per 100,000 WLHIV (with or without antiretroviral therapy). The weighted prevalence of high-grade lesions was 4.1% (95%CI: 3.8%-6.0%) with a double peak at ages 20-24 and 35-39 years. Differences in prevalence of high-grade lesions were also observed by screening approach: co-testing (11.9%), colposcopy (6.0%), cytology (4.2%), and HPV tests (3.2%).Conclusions: The high incidence of invasive cancer and prevalence of high-grade lesions underline challenges to reach the WHO's elimination goal of CC incidence below four per 100,000 among WLHIV. Moreover, the high prevalence of high-grade lesions at younger ages than in the general population is a call to accelerate the implementation of the new WHO screening recommendations in WLHIV.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1008-1018"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0