International Journal of STD & AIDS最新文献

{"title":"Acceptability, usability, and user experiences of an online postal self-sampling approach for HIV and STI testing in Belgium: Test2Know.","authors":"Irith De Baetselier, Corinne Herrijgers, Fien Vanroye, Birgit Baudry, Tim Lebacq, Jacob Verschueren, Vicky Cuylaerts, Chris Kenyon, Maartje van Frankenhuijsen, Thibaut Vanbaelen, Kristien Wouters, Dorien Van den Bossche, Tom Platteau","doi":"10.1177/09564624251342616","DOIUrl":"https://doi.org/10.1177/09564624251342616","url":null,"abstract":"<p><p>BackgroundOnline postal self-sampling (OPSS) for HIV/STI improves testing access and coverage. We assessed the acceptability, usability, and user experiences of the \"Test2Know\" (T2K) OPSS platform in Flanders, Belgium, to inform further implementation.MethodsEligible users completed a risk-assessment to determine infections (HIV, syphilis, chlamydia, gonorrhoea, hepatitis C) and anatomical sites for testing. Self-collected samples were mailed to the laboratory, and results were communicated via the platform. Users completed surveys on acceptability, usability and overall user experience.ResultsOf 131 individuals who received a kit; 98 (74.8%) returned samples. 62.2% were male, 27.6% were men who had exclusively sex with men, and the median age was 29 years. Nearly 43% had never been tested for HIV or did not recall previous testing. 9 (9.2%) tested positive for an STI, all men; 7/9 reported sex exclusively with men, and 2/9 had never tested for HIV. No HIV or HCV infections were detected. Usability and acceptability were 89.2% and 83.3% respectively, nearly 90% would reuse and recommend the platform. However, 45.4% preferred a mixed testing approach due to blood collection challenges.ConclusionsOPSS is highly acceptable and reaches individuals at risk for STI. Further research should explore sustainable integration into Belgian healthcare.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251342616"},"PeriodicalIF":1.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete hematological response with imatinib mesylate in a corticosteroid refractory idiopathic hypereosinophilic syndrome in person living with HIV: A case report.","authors":"Anna Mira Lubis, Evy Yunihastuti, Agnes Stephanie Harahap, Gabriella Anindyah, Amirah Yasmin, Matdoan Rifkiah Aisyah","doi":"10.1177/09564624251338593","DOIUrl":"https://doi.org/10.1177/09564624251338593","url":null,"abstract":"<p><p>We present a case of a 38-year-old person living with HIV (PLHIV) diagnosed with refractory idiopathic hypereosinophilic syndrome (HES). His initial symptoms were pruritic skin rash, dry cough, and diarrhea. The patient was unresponsive to corticosteroid as a first-line therapy. Subsequent treatment with Imatinib mesylate 100 mg per day resulted in excellent and sustained hematological and clinical response, with a likely molecular response as well.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251338593"},"PeriodicalIF":1.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shingles in HIV: Outcome and discovery.","authors":"Mouna Guechchati, Meryem Soughi, Samira Rabhi, Hamza Idrissi Janati, Zakia Douhi, Sara Elloudi, Hanane Baybay, Fatima Zahra Mernissi","doi":"10.1177/09564624251324975","DOIUrl":"10.1177/09564624251324975","url":null,"abstract":"<p><p><b>Background:</b> Herpes zoster (HZ) is a frequent manifestation in people living with HIV (PLHIV), with a significantly higher incidence compared to the general population. It often presents as an early indicator of immunosuppression, making timely diagnosis and treatment crucial. <b>Methods:</b> This retrospective study, conducted from January 2015 to September 2024, analyzed 45 PLHIV diagnosed with HZ. Patients were recruited from the Infectious Diseases Department (for HIV-related HZ cases) and the Dermatology Department (for complicated HZ cases requiring hospitalization). Clinical and demographic data were collected, including ART status, HZ presentation, and treatment outcomes. <b>Results:</b> The mean patient age was 36.35 years, with a male predominance (M/F ratio: 8). Among the cohort, 12 patients had undiagnosed HIV, and HZ was the presenting symptom that led to HIV diagnosis. The thoracic metameric variant was the most common, with erythematous-vesicular, necrotic-hemorrhagic, and bullous forms observed. 21 patients were on antiretroviral therapy (ART), six of whom developed HZ shortly after ART initiation. Treatment involved oral or intravenous acyclovir, with hospitalization required for complicated or multi-metameric forms and high-risk patients. Outpatient management with close monitoring was provided for stable cases. <b>Conclusions:</b> HZ remains a significant opportunistic infection in PLHIV, often serving as a sentinel sign of undiagnosed HIV. Early HIV screening in patients presenting with HZ and timely initiation of antiviral therapy are essential for improved outcomes. Enhanced awareness and integrated HIV-HZ management strategies are crucial in clinical practice.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"506-509"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV self-testing relative to the landscape of HIV testing in Ontario, Canada.","authors":"Patrick O'Byrne, Maya Kesler, Lauren Orser, Michael Kwag, Brook Biggin, Christopher Draenos","doi":"10.1177/09564624251324978","DOIUrl":"10.1177/09564624251324978","url":null,"abstract":"<p><p>BackgroundHIV self-testing may help achieve the UNAIDS 95-95-95 targets because it has the potential to increase testing among equity-denied communities. In 2023, the Public Health Agency of Canada made a one-time $8 million investment into HIV self-testing. We sought to evaluate the outcomes of HIV self-testing, compared to serology in Ontario, Canada.MethodsWe submitted data requests to all agencies involved HIV self-test distribution in Ontario, Canada for 2022-2023. We obtained matching data from the Public Health Ontario Laboratory. We then analyzed for unique test, unique tester, and positivity rate per testing modality.ResultsDuring the analysis period, we found that the laboratory completed an average of 53,606 tests per month for an average number of 44,671 unique persons. For self-tests, there was an average of 1700 tests distributed per month to an average of 678 unique persons. The positivity rate for self-testing was 0.27%, compared to 0.1% for serology.ConclusionsOur results highlight that self-testing can play a role but will not, alone, achieve the UNAIDS 95-95-95 targets. In our jurisdiction, self-testing corresponded with a higher positivity rate but accounted for only a minority of new diagnoses. In short, HIV self-testing is a tool, but not the solution to the HIV epidemic.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"469-474"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to HIV pre-exposure prophylaxis uptake for men who have sex with both men and women: A global scoping review.","authors":"Jodie Crossman, Daniel Richardson","doi":"10.1177/09564624251321564","DOIUrl":"10.1177/09564624251321564","url":null,"abstract":"<p><p>BackgroundAlthough PrEP is a highly effective HIV prevention method, some groups are underrepresented in PrEP uptake. Much HIV prevention research groups gay, bisexual and other men who have sex with men together; however, men who have sex with both men and women (MSWM) may have needs distinct from those who identify as exclusively gay. This scoping review aims to explore documented barriers to PrEP use among MSWM.MethodsLiterature was searched using four databases. Studies were included if data referring to MSWM were reported as a distinct category. Data were extracted using a standardised form, and findings were stratified into relevant categories of the social ecological framework.ResultsAlongside intersectional barriers, MSWM were found to have lower awareness of PrEP, and access sexual health services less than men who have sex only with men. Those who did not identify with the LGBT community often missed out on health promotion messages for this group and were less likely to be offered HIV prevention interventions. MSWM identified more stigmatisation around PrEP use than gay men. However, when aware of PrEP, MSWM were very motivated to use this intervention.ConclusionsNot all MSM will identify within the LGBTQ + community and may miss out on valuable opportunities for HIV prevention. PrEP information should be widely available in a variety of health and community settings. Health care professionals should avoid assumptions when assessing patients and provide information about HIV and STI prevention to all attending sexual health services.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"450-468"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiopoietin-2 and endothelial damage associated with viral load in untreated people living with HIV.","authors":"Paulo Pacelli Bezerra Filizola Tôrres, Gdayllon Cavalcante Meneses, Lana Andrade Lucena Lima, Nicole Coelho Lopes, Leticia Machado de Araújo, Katarina Maria Dos Reis Araújo, Rayane Nascimento de Souza, Raoni de Oliveira Domingues-da-Silva, Alice Maria Costa Martins, Elizabeth De Francesco Daher, Geraldo Bezerra da Silva Junior","doi":"10.1177/09564624251323681","DOIUrl":"10.1177/09564624251323681","url":null,"abstract":"<p><p>BackgroundHIV infection is associated with various types of endothelial damage. Early and accurate diagnosis of endothelial dysfunction may help prevent adverse outcomes. For the first time, this cross-sectional study aims to investigate the effects of increased viral load on endothelial damage and nephrinuria in untreated people living with HIV.MethodsPeople living with HIV not on treatment were included. Laboratory parameters, such as viral load and CD4 count were collected. Participants were divided into three groups according to the tertiles of viral load: low, moderate and high viral load groups. Urinary nephrin, vascular cell adhesion molecule 1 (VCAM-1), angiopoietin-2 and syndecan-1 were quantified by sandwich ELISA assays kits.ResultsA total of 49 patients were examined. The high viral load group (3rd tertile) exhibited a greater frequency of nephrinuria and significantly higher levels of syndecan-1 (58 [48-93] vs 43 [38-65] ng/mL, <i>p</i> = .049) and angiopoietin-2 (2.58 [1.5-3.06] vs 1.34 [0.89-1.76] ng/mL, <i>p</i> = .035). Syndecan-1 levels positively correlated with viral load (rho = 0.452, <i>p</i> = .006), while angiopoietin-2 was positively correlated with viral load (rho = 0.529, <i>p</i> = .001) and inversely correlated with CD4 count (rho = -0.493, <i>p</i> = .003). No significant associations were found for VCAM-1 levels.ConclusionUntreated people living with HIV with elevated viral loads exhibited more pronounced endothelial damage and vascular inflammation, emphasizing the critical importance of early initiation of antiretroviral treatment to mitigate these complications. However, the study's findings should be interpreted with caution due to the small sample size, which may limit the generalizability of the results. Future studies with larger cohorts are needed to confirm these findings.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"498-505"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granulomatous vulvitis complicated by polymicrobial growth.","authors":"Divya Madonna Dsouza, Jacintha Martis, Rochelle Cheryl Monteiro, Jyothi Jayaraman, Prajna Shetty","doi":"10.1177/09564624251318086","DOIUrl":"10.1177/09564624251318086","url":null,"abstract":"<p><p>Granulomatous vulvitis (GV) is a rare chronic inflammatory condition presenting with persistent vulvar swelling and noncaseating granulomas, often mimicking Crohn's disease and sarcoidosis. We report a 21-year-old sexually inactive woman with a five-month history of painless vulvar swelling and occasional itching, complicated by secondary polymicrobial infection. A thorough evaluation excluded other granulomatous diseases, and histopathology revealed noncaseating granulomas, supporting the diagnosis of granulomatous vulvitis. Initial antibiotic therapy was followed by hydroxychloroquine, and intralesional triamcinolone, leading to marked symptom resolution. This case highlights intralesional corticosteroids as an effective first-line treatment and underscores the need for a multidisciplinary and personalized approach in managing GV, particularly in the presence of secondary infections.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"510-512"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 European guideline on the management of <i>Chlamydia trachomatis</i> infections.","authors":"John A White, Nicole Htm Dukers-Muijrers, Christian Jpa Hoebe, Chris R Kenyon, Jonathan Dc Ross, Magnus Unemo","doi":"10.1177/09564624251323678","DOIUrl":"10.1177/09564624251323678","url":null,"abstract":"<p><p>Sexually transmitted <i>Chlamydia trachomatis</i> infections remain common globally and most frequently are asymptomatic. The 2025 European <i>C. trachomatis</i> guideline provides up-to-date guidance regarding indications for testing and treatment of <i>C. trachomatis</i> infections. It includes advice on urogenital and extragenital <i>C. trachomatis</i> testing including the use of self-collected specimens; recommendation to use only validated NAATs for diagnosis; and recommendation to treat all <i>C. trachomatis</i> infections with doxycycline as first line in preference to single-dose azithromycin regimens. The absence of evidence and limited value of broad screening in asymptomatic populations for <i>C. trachomatis</i> infections is also discussed.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"434-449"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing diagnostic accuracy of congenital syphilis using penicillin administration data through the Pediatric Health Information System (PHIS) database.","authors":"John M Flores, Natalie Grills, Jason M Kane, Lilly Cheng Immergluck, Nikki Kasal, Madan Kumar, Allison Bartlett","doi":"10.1177/09564624251324981","DOIUrl":"10.1177/09564624251324981","url":null,"abstract":"<p><p>BackgroundGiven the most recent report of the nationwide rise of congenital syphilis (CS), with over a 773% increase from 2012 to 2021 per the Center for Disease Control and Prevention, we sought to utilize penicillin administration and ICD-10 billing data as proxies to assess the accuracy of diagnosis of congenital syphilis among major tertiary care pediatric hospitals.MethodsThis retrospective cohort study drawing data from 49 major tertiary children's hospitals in the United States sought to determine whether administration of penicillin in infants 30 days or younger, excluding other common infectious diseases treated with the medication, correlated with recently reported congenital syphilis epidemiologic data.Results2290 infants met inclusion criteria and received penicillin therapy, excluding infants with the most common secondary infections treated with penicillin, with 1123 (49.3%) of those included not having a syphilis diagnosis made. Of the neonates with a coded diagnosis of CS, (1107/1162) 95.3% received more than 1 day of penicillin therapy, and those not coded for CS that received more than 1 day of penicillin therapy was 37.9% (428/1128).ConclusionsOur findings found a significant number of infants who had penicillin administration and laboratory and procedural workup performed suggestive of congenital syphilis consideration, without a congenital syphilis diagnosis billed. This may reflect an underestimation of what is notably a growing nationwide pandemic. By addressing the screening and treatment needs of patients with CS, we can help to address some of the socioeconomic inequities in pediatric and maternal healthcare, and further accurately characterize the extent of this increasingly prevalent disease process.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"475-486"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of HIV testing among men in Ghana: Cross-sectional analysis of the 2022 demographic and health survey.","authors":"Sulemana Ansumah Saaka, Roger Antabe, Isaac Luginaah","doi":"10.1177/09564624251324976","DOIUrl":"10.1177/09564624251324976","url":null,"abstract":"<p><p>IntroductionNew HIV infections are on the rise in Ghana, with approximately 16,574 new cases reported in 2022 alone. Although HIV prevalence rate is higher among women aged 15-49 years (2.0 [1.7-2.3]) than men aged 15-49 (1.0 [0.8-1.2]) in Ghana, evidence form the country's 2022 Demographic and health Survey suggest that only 12% of men had ever been tested for HIV once in their lifetime relative to 17% of women, and yet more men (35%) than women (23%) reported having sexual intercourse with persons who were neither their wife nor live-in partners. More so, the Ghana National HIV and AIDS Policy has over the years positively influenced the utilization of HIV testing (HIVT) services among women in Ghana through antenatal care visits. While this policy encourages women to undertake testing with their husbands, most men in the Ghanaian Context rarely accompany their spouse to antenatal care due to several reasons including conflicting work schedules, thus limiting their chances of getting tested. Using a nationally representative dataset, this study adds to the broader literature by exploring the factors associated with HIVT among men.MethodsUsing the 2022 Ghana Demographic and Health Survey (<i>N</i> = 7044 males), and employing multiple logistic regression models, this study explored the factors associated with HIVT among men.ResultsMarried men (OR = 1.723; <i>p</i> < .001), the employed, particularly, those paid in cash only (OR = 2.021; <i>p</i> < .001) and those paid both in cash and kind (OR = 1.823; <i>p</i> < .001), those who had knowledge of HIV test kits (OR = 1.708; <i>p</i> < .001), aware and approve to use Pre-Exposure Prophylaxis (PrEP) (OR = 1.1280; <i>p</i> < .001), as well as those who visited a health facility in the past 6 months (OR = 1.615; <i>p</i> < .001), all significantly reported higher odds of testing. Moreover, Educational attainment, age, household wealth, religion, ethnicity, and the region of residence significantly predicted HIVT in the study context.ConclusionSocio-demographic, economic, geographic and health-related factors have significant influence on the uptake of HIVT among men in Ghana, thus underscoring the need for tailored interventions that consider diverse contextual factors in HIV prevention and healthcare delivery.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"487-497"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}