{"title":"Cure of <i>Trichomonas vaginalis</i> using dequalinium chloride in a patient with an allergy to metronidazole.","authors":"Hannah Reynolds, Sophie Brady, Madeleine Crow","doi":"10.1177/09564624251391235","DOIUrl":"https://doi.org/10.1177/09564624251391235","url":null,"abstract":"<p><p>Given limited treatment options for <i>T</i><i>richomonas vaginalis</i> (TV) in patients with metronidazole allergy and waiting times for desensitization leaving patients in significant discomfort, it is imperative to find alternative options. This case study highlights an example of cure of TV using 24 nightly dequalinium chloride pessaries in a patient with metronidazole allergy, thus presenting a potential treatment option for further study.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251391235"},"PeriodicalIF":1.3,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michelle Chang, Delivette Castor, Craig J Heck, Brian Hernandez, Angelina Gomes, Jason Zucker, Sara Wallach, Jonathan Gelfond, Mina Halpern, Yeycy Donastorg, Martha Perez Mencia, Giselle Lantigua, Samantha Stonbraker, Barbara S Taylor, Silvia Amesty
{"title":"Correlates of asymptomatic sexually transmitted infections among marginalized women in the Dominican Republic.","authors":"Michelle Chang, Delivette Castor, Craig J Heck, Brian Hernandez, Angelina Gomes, Jason Zucker, Sara Wallach, Jonathan Gelfond, Mina Halpern, Yeycy Donastorg, Martha Perez Mencia, Giselle Lantigua, Samantha Stonbraker, Barbara S Taylor, Silvia Amesty","doi":"10.1177/09564624251391234","DOIUrl":"https://doi.org/10.1177/09564624251391234","url":null,"abstract":"<p><p>BackgroundSexually transmitted infections (STIs) continue to cause morbidity among women in resource-constrained settings, where asymptomatic infections are often overlooked due to syndromic management protocols. We investigated correlates of asymptomatic STIs among women in the Dominican Republic (DR).MethodsWe analyzed data collected from cisgender women in DR between 2015 and 2019. Classified groups included pregnant youth (PY), people with HIV (PWH), residents of bateyes (RB), and sex workers (SW). Nucleic acid amplification or rapid plasma reagin tests detected STIs (Chlamydia/Gonorrhoeae/Syphilis/Trichomonas). Asymptomatic comprised no self-reported vaginal discharge, dysuria, groin lymphadenopathy, and genital/anal pain/ulcers. Logistic regressions identified sociodemographic, clinical, and behavioral correlates.ResultsAmong 833 asymptomatic women (median age 29, IQR 19-37), 35% were PY, 27% PWH, 11% RB, and 27% SW. STI prevalence was 24%: most (61%) had Chlamydia and few (≤25%) had Gonorrhoea, Syphilis, or Trichomonas. Asymptomatic STI correlates included age ≤24 (Adjusted Odds Ratio [aOR] = 2.32, [1.65-3.28]), early (≤14) sexual debut (aOR = 1.56, [1.11-2.18]), greater mobility (aOR = 1.41, [1.01-1.97]), lack of regular doctor (aOR = 1.42, [1.01-1.99]), and drug use in last 6 months (aOR = 1.88, [1.07-3.26]).ConclusionsCorrelates of asymptomatic STIs-age, sexual debut, mobility, healthcare access, and drug use-should inform targeted screening and prevention efforts where diagnostic testing is not widely available.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251391234"},"PeriodicalIF":1.3,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disseminated <i>Mycobacterium</i><i>avium</i> complex presenting with solitary splenic abscess in an immunocompromised patient.","authors":"Leah Froehle, Natalia Torres, Audrey Li","doi":"10.1177/09564624251391236","DOIUrl":"https://doi.org/10.1177/09564624251391236","url":null,"abstract":"<p><p><i>Mycobacterium avium</i> complex (MAC) is a common opportunistic infection in advanced human immunodeficiency virus (HIV), but splenic abscess formation is rare. We report a 35-year-old man with newly diagnosed HIV who presented with chronic cough, fever, abdominal discomfort, and pancytopenia. Imaging revealed a solitary splenic abscess. Cultures from sputum, stool, and abscess drainage in addition to lymph node and duodenal biopsies confirmed disseminated MAC. Additional diagnoses included cytomegalovirus viremia, esophageal candidiasis, and MAC-related granulomatous hepatitis. He was treated with rifabutin, ethambutol, and azithromycin) and started on antiretroviral therapy (ART) during admission. The patient was discharged on ongoing MAC therapy and ART. This case highlights a rare presentation of disseminated MAC as a solitary, drainable splenic abscess in severe immunosuppression, underscoring the need to consider atypical focal infections in advanced HIV.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251391236"},"PeriodicalIF":1.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mertcan Dama, Anıl Eker, İsmail Başaran, Tansu Değirmenci
{"title":"Can inflammation predict recurrence? A study on genital warts in men.","authors":"Mertcan Dama, Anıl Eker, İsmail Başaran, Tansu Değirmenci","doi":"10.1177/09564624251390666","DOIUrl":"https://doi.org/10.1177/09564624251390666","url":null,"abstract":"<p><p>BackgroundRecurrence of genital warts remains a significant clinical challenge despite various treatment options. Systemic inflammatory indices derived from routine blood counts, such as the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have recently been investigated as potential prognostic markers in HPV-related diseases.MethodsThis retrospective study included 217 male patients who underwent electrocauterisation for penoscrotal warts between March and September 2024. Patients were classified as having primary or recurrent lesions at presentation. Preoperative neutrophil, lymphocyte, and platelet counts were used to calculate inflammatory indices, and their associations with recurrence were analysed. Primary patients were also followed for 6 months to assess post-treatment recurrence.ResultsRecurrent cases (44.2%) exhibited significantly higher SII, NLR, and PLR values compared with primary cases (<i>p</i> = 0.004, <i>p</i> = 0.011, and <i>p</i> = 0.047, respectively). Smoking prevalence was greater among recurrent patients (<i>p</i> = 0.008). Among primary patients, those who experienced recurrence at 6 months had higher SII (<i>p</i> = 0.006) and NLR (<i>p</i> = 0.014). Multivariate analysis identified SII as an independent predictor of recurrence (OR = 1.42, 95% CI 1.08-1.91, <i>p</i> = 0.027).ConclusionsElevated SII and NLR levels are associated with an increased risk of genital wart recurrence, and SII independently predicts recurrence among primary cases. These inexpensive and readily available markers may aid in recurrence risk stratification and follow-up planning. Longer prospective studies incorporating HPV genotyping and behavioural risk factors are warranted to confirm these findings.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251390666"},"PeriodicalIF":1.3,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Conrad Hempel, Florentine Gerhardt, Sonja Grunewald, Viktor Schnabel, Jan-Christoph Simon, Till Mittank-Weidner
{"title":"Real-world management of male patients with condylomata acuminata in Germany: A retrospective single-center case analysis.","authors":"Conrad Hempel, Florentine Gerhardt, Sonja Grunewald, Viktor Schnabel, Jan-Christoph Simon, Till Mittank-Weidner","doi":"10.1177/09564624251390619","DOIUrl":"https://doi.org/10.1177/09564624251390619","url":null,"abstract":"<p><p>BackgroundCondylomata acuminata (genital warts) are one of the most common sexually transmitted infections, mainly caused by human papillomavirus types 6 and 11. While vaccination programs have reduced the incidence in young women since 2006, the healthcare situation for men in Germany remains poorly studied. The aim of this study was to analyse the reality of care for men with condylomata acuminata in both outpatient and inpatient settings.MethodsA retrospective analysis was conducted on 239 male patients treated for condylomata acuminata between 2020 and 2024 at the Department of Dermatology, Venerology and Allergology, University Medical Center Leipzig. The data collected encompassed demographic information, comorbidities including immune status and sexually transmitted infections, prior medical consultations, the type of treatment provided (outpatient or inpatient), where applicable duration of hospitalization, our therapeutic approach, and the overall recurrences rate.ResultsThe mean age of the patients was 41.1 years. 83.3% were treated on an outpatient basis, while 16.7% received inpatient or short-term inpatient care. The average length of stay for inpatients was 4.03 days (standard deviation: 2.75). Prior diagnostics were documented in 15.1% of cases. Overall recurrences occurred in 22.2% of patients. Only 7.5% had a documented HPV vaccination status.ConclusionsThese results highlight the significant disease burden of condylomata acuminata among men in Germany, with the majority of cases managed on an outpatient basis. The insufficient vaccination rate and low rates of prior diagnostics indicate deficits in prevention and structured care. Intensifying vaccination programs and optimizing treatment pathways could reduce the disease burden and the need for inpatient care.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251390619"},"PeriodicalIF":1.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathkapach K Rattanapitoon, Natnapa H Padchasuwan, Thawatchai Aeksanti, Schawanya K Rattanapitoon
{"title":"At-home STBBI testing in Canada: Towards a hybrid model of equitable, scalable care.","authors":"Nathkapach K Rattanapitoon, Natnapa H Padchasuwan, Thawatchai Aeksanti, Schawanya K Rattanapitoon","doi":"10.1177/09564624251388209","DOIUrl":"https://doi.org/10.1177/09564624251388209","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251388209"},"PeriodicalIF":1.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carmen H Logie, Zerihun Admassu, Frannie MacKenzie, David Puvaneyshwaran, Sarah Van Borek, Bibiche Mbende, Luc Magloire Anicet Boumba, Laure Stella Ghoma Linguissi, Hugues Loemba
{"title":"Findings from a participatory mapping study to increase HIV and STI testing with female sex professionals in Pointe Noire, Congo.","authors":"Carmen H Logie, Zerihun Admassu, Frannie MacKenzie, David Puvaneyshwaran, Sarah Van Borek, Bibiche Mbende, Luc Magloire Anicet Boumba, Laure Stella Ghoma Linguissi, Hugues Loemba","doi":"10.1177/09564624251385055","DOIUrl":"https://doi.org/10.1177/09564624251385055","url":null,"abstract":"<p><p>BackgroundSex workers are disproportionately affected by HIV and sexually transmitted infections (STI) in the Republic of Congo. We conducted a one-group pre-post test participatory mapping (PM) intervention to increase HIV/STI testing uptake with female sex professionals (FSP) in Pointe Noire, Congo.MethodsWe engaged a peer-driven sample of FSP in Pointe Noire in a 2-day PM intervention. Voluntary HIV and STI testing and treatment was offered at Time 2 (T2) (directly post-intervention) until Time 3 (T3) (8-week post intervention). To measure HIV/STI testing changes between Time 1 (T1) (baseline, lifetime HIV/STI testing), T2, and T3, we used a generalized estimating equation model with robust standard errors, using an unstructured correlation matrix to account for within-subject correlations.ResultsAmong <i>n</i> = 99 participants (mean age: 25.5, standard deviation = 6.5), in analyses adjusted for age and sex work duration, there were significant increases at T2 in uptake of HIV testing (adjusted Odds Ratio [aOR] = 2.42; 95% CI = 1.31-4.48) and STI testing (aOR = 2.40; 95% CI = 1.27-4.54), as well as at T3 (HIV testing: aOR = 7.37; 95% CI = 2.82-19.23, STI testing: aOR = 5.88; 95% CI = 2.82-12.24), compared to baseline.ConclusionsFindings signal the promise of community-based approaches such as participatory mapping for increasing HIV/STI testing uptake with FSP in Pointe Noire.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251385055"},"PeriodicalIF":1.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Gabriella Donà, Mauro Zaccarelli, Massimo Giuliani, Christof Stingone, Laura Gianserra, Francesca Di Tullio, Eugenia Giuliani, Alessandra Latini
{"title":"Early uptake of doxycycline prophylaxis among MSM in Rome: Insights from a reference STI clinic.","authors":"Maria Gabriella Donà, Mauro Zaccarelli, Massimo Giuliani, Christof Stingone, Laura Gianserra, Francesca Di Tullio, Eugenia Giuliani, Alessandra Latini","doi":"10.1177/09564624251375877","DOIUrl":"https://doi.org/10.1177/09564624251375877","url":null,"abstract":"<p><p>BackgroundPrompt doxycycline use (200 mg taken 24-72 hours after sexual activity, i.e., post-exposure prophylaxis, Doxy-PEP), effectively reduces chlamydia and syphilis acquisition in men who have sex with men (MSM) and individuals experiencing recurrent STIs. Considering the IUSTI Europe position statement and recent guidelines from the CDC, this study investigated the use of doxycycline to prevent STIs among MSM attendees of an STI/HIV center in Rome, Italy.MethodsFrom June 2024 to February 2025, an anonymous self-administered questionnaire was used to collect data on sexual behaviors, HIV status, HIV pre-exposure prophylaxis (PrEP), STI history, recreational substances, and doxycycline PrEP/PEP use. Logistic regression analyzed associations between Doxy-PEP/PrEP use and behavioral/clinical factors.ResultsTwo hundred and ninety MSM were enrolled. Among them, 9.3% reported using Doxy-PEP/PrEP, with nearly half accessing it without medical supervision. Multivariable analysis showed significant associations between doxycycline use and having ≥20 sexual partners, erectile drug use, and condomless anal sex.ConclusionsWhile doxycycline remains an uncommon choice for STI prevention among our attendees, its usage is linked to individuals engaging in sex with multiple partners. These findings highlight the urgency of national guidelines to address informal prophylactic antibiotic use and ensure supervised STI prevention strategies among individuals at elevated risk for bacterial STIs.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251375877"},"PeriodicalIF":1.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alissa Ambrose, Susannah Ramshaw, Lauren Bull, Akash Kotecha, Ellen Dwyer
{"title":"Outcomes from sexual health outreach in asylum seekers in the London borough of Hounslow.","authors":"Alissa Ambrose, Susannah Ramshaw, Lauren Bull, Akash Kotecha, Ellen Dwyer","doi":"10.1177/09564624251382060","DOIUrl":"https://doi.org/10.1177/09564624251382060","url":null,"abstract":"<p><p>BackgroundSexual Health Hounslow completed targeted outreach in local asylum seeker populations. The methods and results of STI and BBV screening in this population are described.MethodsA dedicated clinic 0.4 miles from the largest contingency hotel opened in January 2023, advertised through targeted hotel-based outreach. A hotel-based clinic opened in 2024.A retrospective case-note review of all asylum seekers attending sexual health services in Hounslow between 01/02/2011 and 01/12/2023 was conducted.Results192 asylum seekers were included. 80 (41.7%) required translators. 111 (57.8%) were not registered with a GP. Thirty-three (17.2%) had a safeguarding concern. Eleven (9.2%) service users tested positive for HIV, two (1.7%) had a positive Hepatitis B surface antigen and three (2.5%) had a positive Hepatitis C antibody. Three (2.5%) required treatment for syphilis, six (4.5%) tested positive for gonorrhoea and 17 (12.7%) tested positive for chlamydia.ConclusionsRates of STIs in this cohort were high: 9.2% HIV and 12.7% <i>Chlamydia</i> prevalence versus 0.17% and 0.29% respectively in England. Patterns of STIs in this cohort differed from national trends. Targeted outreach can improve engagement, testing and care in excluded populations.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251382060"},"PeriodicalIF":1.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Kan, Joe Smith, Jessica Whittock, Sophie Jones, Sophia Zentner, Rachel Nicholas, Charlotte E Cohen
{"title":"Gender and sexual orientation minority (GSM) survivors of domestic abuse (DA): Impact of Galop Independent Domestic Violence Advisor (IDVA) co-located within an acute Trust.","authors":"Julia Kan, Joe Smith, Jessica Whittock, Sophie Jones, Sophia Zentner, Rachel Nicholas, Charlotte E Cohen","doi":"10.1177/09564624251384512","DOIUrl":"https://doi.org/10.1177/09564624251384512","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251384512"},"PeriodicalIF":1.3,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}