International Journal of STD & AIDS最新文献

{"title":"Incidence of and outcomes of pregnancy in adolescents with perinatally-acquired HIV infection in Southern Africa.","authors":"Nyasha Veronica Dzavakwa, Molly Chisenga, Hilda Banda-Mabuda, Cassandra Namukonda, Lackson Kasonka, Tsitsi Bandason, Nicol Redzo, Hilda Angela Mujuru, Katharina Kranzer, Victoria Simms, Rashida A Ferrand","doi":"10.1177/09564624251352066","DOIUrl":"https://doi.org/10.1177/09564624251352066","url":null,"abstract":"<p><p>BackgroundThe scale-up of antiretroviral therapy (ART) has enabled more children living with HIV to reach adolescence and become sexually active. We investigated pregnancy incidence and outcomes among adolescents with perinatally acquired HIV enrolled in a multi-country trial of vitamin D and calcium carbonate supplementation (VITALITY; PACTR202009897660297).MethodsBetween February and November 2021, 842 adolescents aged 11-19 years from Zambia and Zimbabwe on ART for at least 6 months were enrolled. Pregnancies occurring during 96 weeks of follow-up (February 2021-October 2023) were identified through self-report or testing. Pregnancy incidence rate was calculated among post-menarche participants using survival time analysis.ResultsThirty-five adolescents (median age 18, range 13-22) became pregnant, 21 in Zambia, 14 in Zimbabwe. Overall pregnancy incidence was 4.6 per 100 person-years (95% CI 3.3-6.4), higher in those ≥15 years (6.8 per 100 person-years, 95% CI 4.8-9.7). Three pregnancies ended in miscarriage; 32 resulted in live births. Of the 30 adolescents with live births and available data, 26 (86.7%) infants were tested for HIV at birth: 24 were HIV-negative, two had unknown results. Twenty-nine received HIV prophylaxis. At 6 weeks, 19/30 infants were retested for HIV: 16 were HIV-negative. Twenty-one of 32 pregnant adolescents were in school at conception, and 4 (19.0%) returned post-pregnancy. Overall, 23/33 (69.7%) started contraception, a median of 9 weeks after delivery/miscarriage.ConclusionPregnancy incidence is high among adolescents with HIV, especially older adolescents. While prevention of vertical HIV transmission is effective, education re-integration and timely contraception uptake remain limited.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352066"},"PeriodicalIF":1.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circinate balanitis in HLA B27 spondyloarthrithis: A report of two cases.","authors":"Ammu Shanmughan, Betsy Ambooken, Jijith Krishnan, Vayapurath Gangadharan Binesh","doi":"10.1177/09564624251352051","DOIUrl":"https://doi.org/10.1177/09564624251352051","url":null,"abstract":"<p><p>Circinate balanitis is a characteristic mucocutaneous lesion commonly associated with reactive arthritis (ReA), previously described as Reiter's disease. It typically presents alongside other ReA symptoms, including urethritis, conjunctivitis, and arthritis, but can occasionally occur as an isolated finding. We report two cases of circinate balanitis occurring in patients with HLA B27-positive spondyloarthritis, without the classical triad of reactive arthritis. A 32-year-old male presented with recurrent erosions on the glans penis for 2 years, with a history of HLA B27-positive spondyloarthritis. He was on treatment with tofacitinib, deflazacort, and sulfasalazine. A skin biopsy from the scrotum confirmed the diagnosis of psoriasis. MRI spine and sacrum showed anterior syndesmophyte formation and right-sided sacroillitis. The final diagnosis was circinate balanitis in association with HLA B27-positive psoriatic spondyloarthritis. A 41-year-old male presented with recurrent erosions on the glans penis for 4 years with history of HLA B27 positivity, and ankylosing spondyloarthritis. The biopsy from the glans penis showed squamous hyperplasia. MRI spine and pelvis was suggestive of inflammatory spondyloarthropathy of the cervical, dorsal and lumbar spine with bilateral sacroilitis. The final diagnosis was circinate balanitis with primary ankylosing spondylitis. Both cases highlight the diagnostic challenge of distinguishing between different forms of spondyloarthritis in the presence ofcircinate balanitis.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352051"},"PeriodicalIF":1.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necrotic skin reaction following the administration of intramuscular injections of long-acting cabotegravir/rilpivirine and alternatively-sourced testosterone.","authors":"Shahid Bukhari, Ruth Byrne, Yemi Daramola, Christina Antoniadi, Marta Boffito","doi":"10.1177/09564624251352050","DOIUrl":"https://doi.org/10.1177/09564624251352050","url":null,"abstract":"<p><p>In this case, we describe a 52-year-old man who was switched to long-acting cabotegravir/rilpivirine (CAB/RPV LA) injectable antiretroviral therapy (ART) on a background of well-controlled HIV. He subsequently developed a painful and swollen area on his right ventrogluteal region 10 days after his first CAB/RPV LA injections when he injected alternatively sourced testosterone in the same region. Examination findings showed a firm and defined lump with ecchymosis noted on the skin overlying. His initial blood results did not show any gross abnormalities and an ultrasound of the area was equivocal. After being reviewed in ambulatory care, the emergency department and an outpatient plastic surgery clinic settings over the course of 3 weeks, the swelling and skin changes gradually resolved. He was then switched back to oral ART on subsequent review.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352050"},"PeriodicalIF":1.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV self-testing knowledge, attitudes, and acceptance in New York City.","authors":"Abhishek R Mogili, Omi Singh, Parth Dhruve, Anna Martens, Rachel Kasdin, Sarah Weihl, Bashar Zaidat, Matthew Erdos, Beverly Forsyth","doi":"10.1177/09564624251355833","DOIUrl":"https://doi.org/10.1177/09564624251355833","url":null,"abstract":"<p><p>BackgroundHIV testing is a critical strategy for prevention. During the COVID-19 pandemic, many community-based organizations (CBOs) offering free HIV testing were unable to provide in-person services. Innovations like free HIV Self-Testing (HIVST), provided a solution and can be done outside clinical settings, help address barriers such as cost, availability, and stigma. However, HIVST uptake remains low in resource-rich settings like the US, and best practices for integrating it into existing HIV services are still undetermined.MethodsGay Men's Health Crisis (GMHC) partnered with the NYC Health Department (NYCDOHMH) to distribute free HIVST kits. From April to February 2023, survey data was collected to assess client barriers and HIVST's role in a differentiated service model.ResultsThe survey had 201 participants, 151 in the in-person testing group and 50 in the at-home group. The study revealed that 34.7% of in-person respondents were unaware that HIVST was an option. In-person testers were less likely to trust an HIVST test result compared with an in-person test result, and all testers were more likely to choose the same method they previously used. Nevertheless, there was interest in HIVST: 24% of in-person testers indicated interest in HIVST for their next test.ConclusionsHIVST can supplement in-person testing in settings with fragmented healthcare systems and limited continuity of care. Respondents demonstrated low awareness but notable interest in HIVST, suggesting its potential to improve access, particularly for populations more likely to use it than in-person options. Further research is needed to optimize HIVST implementation within existing service models.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251355833"},"PeriodicalIF":1.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Mycoplasma genitalium</i> treatment strategies in the era of significant macrolide resistance: Findings from a multi-centre audit in Northwest England.","authors":"Izuchukwu Ezeh, Bethany Harrison, Eva Klesnik-Edwards, Alisha Varia, Emily Clarke, Vincent Lee","doi":"10.1177/09564624251353583","DOIUrl":"https://doi.org/10.1177/09564624251353583","url":null,"abstract":"<p><p>IntroductionAzithromycin is first-line for uncomplicated <i>Mycoplasma genitalium</i> (Mgen) treatment in UK and European guidelines, however the rates of azithromycin resistance have increased significantly in recent years leading to higher rates of treatment failure. This study aims to review the disease epidemiology to guide service improvement.MethodsWe undertook a retrospective case note review of 1036 persons treated for Mgen over 1067 Mgen-related attendances. We obtained data on demographics, site(s) of infection, antibiotic resistance, treatment regimen received and results of test of cure.Results71.1% (<i>n</i> = 759) patients received the recommended first-line regimen of doxycycline and azithromycin. Moxifloxacin is the recommended first-line management for macrolide-resistant or complicated infection. 15% (<i>n</i> = 155) patients received moxifloxacin alone as first-line treatment, and 6.9% (<i>n</i> = 72) patients received doxycycline and moxifloxacin dual therapy. 72.9% (<i>n</i> = 753) samples were successfully tested for macrolide resistance. Of these, 55.5% (<i>n</i> = 418) showed macrolide resistance. 20.6% (<i>n</i> = 7) showed fluoroquinolone resistance.ConclusionsResistance data show a macrolide resistance rate of 55.5% across our region, and at least 1 in 10 persons were inappropriately screened for Mgen. We propose a multi-pronged approach which includes strict adherence to testing criteria, local resistance testing, resistance-guided management as well as innovative approaches to improve test of cure rates.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251353583"},"PeriodicalIF":1.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The characteristics of men who have sex with men with <i>Blastocystis</i>: A systematic review.","authors":"Sophie Ettinger, John C Castle, Julian Robinson, Nicolas Pinto-Sander, Daniel Richardson","doi":"10.1177/09564624251349910","DOIUrl":"https://doi.org/10.1177/09564624251349910","url":null,"abstract":"<p><p>Objective<i>Blastocystis</i> is an enteric parasite which can cause gastrointestinal symptoms and may be sexually transmissible in men who have sex with men (MSM). This review aimed to explore the characteristics of MSM with <i>Blastocystis</i>.MethodFive bibliographical databases (CINAHL, EMBASE, MEDLINE, EMCARE, Cochrane-central) were searched for manuscripts which explored the characteristics of MSM with <i>Blastocystis</i> written in English, French or Spanish in October 2024. Following the initial search, duplicates were removed, and two authors independently conducted a full text review and risk of bias assessment using the Joanna Briggs Institute toolkits. Narrative data were synthesised to generate themes. The protocol was registered on PROSPERO(ID:CRD42024582946).ResultsFourteen manuscripts were included in this review; from Australia (<i>n</i> = 2), Spain (<i>n</i> = 2), Denmark (<i>n</i> = 2), USA (<i>n</i> = 2), UK(<i>n</i> = 1), Italy (<i>n</i> = 1), France (<i>n</i> = 1), Germany (<i>n</i> = 1), Canada (<i>n</i> = 1) & China (<i>n</i> = 1) published between 1988 and 2022. The manuscripts were case-reports (<i>n</i> = 2), case-series (<i>n</i> = 1) and cross-sectional studies (<i>n</i> = 11) and included 693 MSM who tested positive for <i>Blastocystis.</i> The majority of MSM in this review were living with HIV which either represents a biological, a behavioural (surrogate) characteristic or a confounding association. This review also highlighted demographic (being asymptomatic), behavioural (multiple sexual partners, recent (tropical) travel, oral-anal sex) and infection (co-infection with STI [<i>N</i>. <i>gonorrhoeae, C</i>. <i>trachomatis</i>], co-infection with other sexually transmissible enteric pathogens [<i>Salmonella spp., Campylobacter</i> spp.<i>, E.coli, E</i>. <i>histolytica, G</i>. <i>duodenalis, Cryptosporidium</i> spp.], co-infection with intestinal spirochaetosis<i>,</i> co-infection with a non-pathogenic enteric parasite) characteristics of MSM who tested positive for <i>Blastocystis.</i>ConclusionThis review serves as a resource for future public health control strategies, clinical guidelines and research to understand the sexual transmissibility of <i>Blastocystis</i> in MSM.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251349910"},"PeriodicalIF":1.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Chlamydia trachomatis</i> infections among men who have sex with men and transgender women attending four community-based clinics in Thailand, 2019-2021.","authors":"Jutatip Sillabutra, Sarika Pattanasin, Wachiraporn Wanichnopparat, Akarin Hiransuthikul, Sutthi Jareinpituk, Sujittra Suriwong, Nittaya Phanuphak, Pratana Satitvipawee","doi":"10.1177/09564624251352058","DOIUrl":"https://doi.org/10.1177/09564624251352058","url":null,"abstract":"<p><p>Background<i>Chlamydia trachomatis</i> (CT) infections are prevalent and often asymptomatic. Point-of-Care (PoC) tests offer a diagnostic option. We described the incidence and predictors of CT infection using secondary data collected from men who have sex with men (MSM) and transgender women (TGW) attending Community-Based Organizations (CBOs) clinics in Thailand.MethodsMSM and TGW aged ≥18 and had HIV risks were enrolled and followed for 12 months with visits every 3 months. Behavioral risks and Sexually Transmitted Infection testing were assessed at every visits. Specimens were collected via pharyngeal swab, urine sample, rectal swab, and neovaginal swab for TGW. These specimens were tested for CT using PoC test. The incidence was calculated using survival analysis, and the Cox regression model for multiple failures.ResultsFrom 2019-2021, 1886 participants were enrolled. Of these, 89.7% were MSM; 10.3% were TGW: 20.7% were lost to follow-up. Of the remaining participants, 18.2% had CT at baseline, with 36.4% experiencing repeat infections. The incidence rate of CT was 42.9 infections per 100 person-years. Predictors of CT infections included enrollment year, age 18-24 years, HIV status, pre-exposure prophylaxis and condom use.ConclusionRepeat CT infections were common. CBOs should incorporate POC STI testing into services, and the provision of STI prevention strategies.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352058"},"PeriodicalIF":1.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV prevalence and prevention behaviors among immigrant men who have sex with men in Brazil and Portugal.","authors":"Alvaro Francisco Lopes de Sousa, Caíque Jordan Nunes Ribeiro, Guilherme Reis de Santana Santos, Matheus Vinícius Cardoso Santos, José Flávio Cerqueira Dos Santos Júnior, Emerson Lucas Silva Camargo, Ana Paula Morais Fernandes, Talita Morais Fernandes, Liliane Moretti Carneiro, Isabel Amélia Costa Mendes","doi":"10.1177/09564624251347491","DOIUrl":"https://doi.org/10.1177/09564624251347491","url":null,"abstract":"<p><p>BackgroundThis study aimed to assess HIV prevalence and associated sexual behaviors among immigrant men who have sex with men (MSM) in Brazil and Portugal, recognizing the elevated vulnerability of this population due to sociocultural and structural barriers.MethodsA cross-sectional online survey was conducted between January 2020 and May 2021 with 2033 immigrant MSM. Participants were recruited using snowball sampling through dating applications. Data were self-reported and analyzed to identify associations between sexual behaviors and HIV status.ResultsThe overall HIV prevalence was 11.7%. Higher-risk sexual practices were frequent, including receptive anal intercourse and having multiple sexual partners. Conversely, low adoption of preventive behaviors such as sexual abstinence and non-penetrative sex was observed. Condomless sex was commonly justified by trust in partners or recent negative HIV test results. Factors independently associated with unprotected sex included being versatile or receptive in anal sex and not disclosing HIV status on dating apps. Gaps in HIV prevention knowledge and engagement were also identified.ConclusionsImmigrant MSM in Brazil and Portugal experience a high burden of HIV and engage in behaviors that increase their risk of infection. Cultural and structural barriers-such as language difficulties, limited healthcare access, and stigma-contribute to inadequate prevention practices. These findings highlight the urgent need for targeted, culturally competent public health interventions to expand access to HIV prevention strategies and reduce transmission risk in this underserved population.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251347491"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term efficacy and safety of fixed-dose dolutegravir-lamivudine in people with HIV: A retrospective study from India.","authors":"Vinay Kulkarni, Ritu Parchure, Shridevi Gundu, Trupti Darak, Kailas Kurkute, Ketan Kulkarni","doi":"10.1177/09564624251352064","DOIUrl":"https://doi.org/10.1177/09564624251352064","url":null,"abstract":"<p><p>BackgroundHIV continues to be a significant health concern across the world. Combination antiretroviral therapy (cART) comprising of three-drug regimens has improved clinical outcome but involves long-term toxicity concerns. Hence, to reduce drug exposure, interest in two-drug regimens has increased. This study evaluates the real-world efficacy and safety of a two-drug regimen that is a fixed-dose combination (FDC) of Dolutegravir 50 mg and Lamivudine 300 mg tablets in people living with HIV (PLHIV) in India.MethodsThe retrospective data included PLHIV aged ≥18 years, virally suppressed at baseline, and switched to DTG/3TC between November 2021 and April 2022. Patients were followed for 96 weeks, with routine clinical and laboratory assessments. Virological failure was defined as viral loads >1000 copies/mL, while safety assessments tracked adverse events (AEs), weight gain, and metabolic parameters.ResultsAmong 218 patients (mean age 48.08 ± 10.58 yrs), 97.8% achieved virological suppression at 96 weeks with sustained virological suppression at key time points (24, 48, 72, and 96 weeks). CD4 counts improved significantly (<i>p</i> = .002), specifically in females. Body weight increased moderately, with 16.28% experiencing ≥10% weight gain by 96 weeks. Minor statistically significant variations in cholesterol, triglycerides, and creatinine levels were observed. Nine patients discontinued DTG/3TC due to AEs, primarily weight gain and gastrointestinal issues.ConclusionThe study demonstrates that the DTG/3TC FDC is an effective, safe, and well-tolerated regimen for maintaining virological suppression in real-world settings, supporting its viable use as a switching strategy in reducing drug exposure and managing long-term toxicity.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352064"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of tenofovir alafenamide- or tenofovir disoproxil fumarate-containing regimens in adults with treatment-naïve HIV-hepatitis B co-infection.","authors":"Fehmi Tabak, Dilek Yıldız Sevgi, Esra Zerdali, Ahmet Furkan Kurt, Hayat Kumbasar Karaosmanoğlu, Meliha Meriç Koç, Alper Gunduz, Ahsen Öncül, İnci Yilmaz Nakir, Esra Canpolat Ünlü, Ozlem Altuntaş Aydın, Bilgul Mete","doi":"10.1177/09564624251352345","DOIUrl":"https://doi.org/10.1177/09564624251352345","url":null,"abstract":"<p><p>BackgroundHepatitis B (HBV) infection affects 4%-14% of people with HIV infection in Turkey. Tenofovir alafenamide (TAF) is highly effective in treatment of HIV infection. While it is active against HBV, data on the use in HIV-HBV co-infection are limited.Patients and MethodsWe analyzed the efficacy of tenofovir disoproxil fumarate (TDF)- and TAF-containing regimens in patients with HIV-HBV co-infection from six centers in Istanbul, Turkey. The results of the cohort of 36 months were presented.Results259 patients were enrolled: 146 and 113 were receiving TAF- and TDF-containing regimens respectively. Baseline characteristics were comparable except TAF-containing group was older; had higher CD4 cell count and lower rate of CD4 count ≤200 cells/μL. Baseline HIV-RNA were 8.2 log copies/mL and 6.8 log in TAF- and TDF-containing groups, respectively (<i>p</i> = .059) and HBV-DNA levels were 8.1 log IU/mL in both groups. Thirty-eight and 39% of the patients were HBeAg-positive. After 36 months, undetectable HBV-DNA was noted in 88% and 87%, and undetectable HIV-RNA in 85% and in 83% of TAF and TDF-containing groups, respectively. The increase in mean CD4 cell was significant in both groups: Δ = 311 cells/μL in TAF- and Δ = 393 cells/μL in TDF-containing groups. Rates of HBeAg loss (63% vs 57%), HBeAg seroconversion (35% vs 29%), HBsAg loss (29% vs 27%), and HBsAg seroconversion (23% vs 16%) were comparable at 36 months of therapy.ConclusionThis real-life study showed that both TAF- and TDF-containing regimens are effective in co-infected patients. The rates of HBsAg loss seemed higher than those in HBV-monoinfected patients.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352345"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}