Zoe Ottaway, Lucy Campbell, Julie Fox, Fiona M Burns, Lisa Hamzah, Sarah Schoeman, David Price, Amanda Clarke, Sarah L Pett, Denis Onyango, Caroline Sabin, Robert F Miller, Frank A Post
{"title":"Post-acute sequelae of COVID-19 in people of Black ethnicities living with HIV in the United Kingdom.","authors":"Zoe Ottaway, Lucy Campbell, Julie Fox, Fiona M Burns, Lisa Hamzah, Sarah Schoeman, David Price, Amanda Clarke, Sarah L Pett, Denis Onyango, Caroline Sabin, Robert F Miller, Frank A Post","doi":"10.1177/09564624251334227","DOIUrl":"10.1177/09564624251334227","url":null,"abstract":"<p><p>BackgroundThe COVID-19 pandemic disproportionately affected people of Black ethnicities, however, there are limited data on the post-acute sequelae of COVID-19 infection in these populations, and none in those with HIV.MethodsWe conducted a cross-sectional study in people of Black ethnicities with HIV in the UK. Participants were assessed for functional impairment, frailty, respiratory symptoms, anxiety and depression; they were also asked to rate aspects of their physical and mental health on a scale from 1 (poor) to 10 (excellent), both at enrolment and prior to the pandemic. We report associations with COVID-19 history and recovery status.ResultsWe enrolled 183 participants between June 2021 and October 2022, 131 (72%) of whom reported COVID-19. A history of COVID-19 was associated with a reduced ability to carry out usual activities (OR 2.54 [1.03-6.21], <i>p</i> = 0.04), an increase in pain, tiredness and breathlessness, and overall decline in physical health. Of those with a history of COVID-19, 111 (85%) reported to have fully recovered. Those who had not fully recovered reported poorer functional status (<i>p</i> < 0.001) and had higher generalised anxiety scores (<i>p</i> = 0.02). Objective measures of physical function were similar in those who reported no COVID-19, COVID-19 with full recovery, and COVID-19 with incomplete recovery.ConclusionsIn this cohort of Black people with HIV, participants with a history of COVID-19 reported a reduced ability to carry out activities of daily living and various other health issues. Although most people reported full recovery from COVID-19, self-reported limitations in functional status and anxiety were common sequelae.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"602-610"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Mira Lubis, Evy Yunihastuti, Agnes Stephanie Harahap, Gabriella Anindyah, Amirah Yasmin, Matdoan Rifkiah Aisyah
{"title":"Complete hematological response with imatinib mesylate in a corticosteroid refractory idiopathic hypereosinophilic syndrome in person living with HIV: A case report.","authors":"Anna Mira Lubis, Evy Yunihastuti, Agnes Stephanie Harahap, Gabriella Anindyah, Amirah Yasmin, Matdoan Rifkiah Aisyah","doi":"10.1177/09564624251338593","DOIUrl":"10.1177/09564624251338593","url":null,"abstract":"<p><p>We present a case of a 38-year-old person living with HIV (PLHIV) diagnosed with refractory idiopathic hypereosinophilic syndrome (HES). His initial symptoms were pruritic skin rash, dry cough, and diarrhea. The patient was unresponsive to corticosteroid as a first-line therapy. Subsequent treatment with Imatinib mesylate 100 mg per day resulted in excellent and sustained hematological and clinical response, with a likely molecular response as well.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"672-675"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefano Veraldi, Italo Francesco Aromolo, Gianluca Nazzaro
{"title":"The dangers of naked sunbathing: Cutaneous larva migrans on the penis.","authors":"Stefano Veraldi, Italo Francesco Aromolo, Gianluca Nazzaro","doi":"10.1177/09564624251336993","DOIUrl":"10.1177/09564624251336993","url":null,"abstract":"<p><p>Cutaneous larva migrans (CLM) of genitals has been very rarely reported in the literature. We describe a case of CLM of the penis in a 38-year-old Caucasian patient who sunbathed naked whilst in Phuket island (Thailand). The patient was successfully treated with 1% ivermectin cream (2 applications/day for 2 weeks), under occlusive dressing.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"670-671"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Breaking barriers to PrEP access in Italy: The Florence STD center \"model\" for nationwide implementation.","authors":"Luigi Pisano, Nicola Pimpinelli","doi":"10.1177/09564624251333493","DOIUrl":"10.1177/09564624251333493","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"682-683"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcel G Maciel, Ubandoma Andefiki, Ilemobayo V Fasogbon, Ibrahim Awache, Michael N Yakubu
{"title":"Rollet's mixed chancre in an adult woman diagnosed in the state of Amazonas, Brazil: A case report.","authors":"Marcel G Maciel, Ubandoma Andefiki, Ilemobayo V Fasogbon, Ibrahim Awache, Michael N Yakubu","doi":"10.1177/09564624241267133","DOIUrl":"10.1177/09564624241267133","url":null,"abstract":"<p><p>Rollet's Mixed Chancre is a clinical presentation of sexually transmitted infections (STI), involving the coexistence of <i>Haemophilus ducreyi</i> and <i>Treponema pallidum</i> at the same site of infection. Here, we report a case of Rollet's Mixed Chancre in a 32-year-old Brazilian woman. On physical examination she presented with a unilateral bubo measuring approximately 5 × 3 centimeters in diameter, in association with an ulcerated lesion that evolved for 10 days at the inguinal region. She was successfully treated at a health unit with antibiotics. Rollet's Mixed Chancre, though uncommon, poses diagnostic challenges. This case highlights the importance of considering rare STI manifestations. Moreover, comprehensive STI screening and adherence to treatment guidelines are essential for effective management and prevention of further transmission.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"667-669"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new era in HIV treatment: Evaluating the benefits of lenacapavir.","authors":"Sinnha Kumari, Nikil Kumar, Muhammad Saad Khan","doi":"10.1177/09564624251333499","DOIUrl":"10.1177/09564624251333499","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"680-681"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ella P Davies, Motoyuki Tsuboi, Jayne Evans, Jane Rowley, Eline L Korenromp, Tim Clayton, R Matthew Chico
{"title":"A global meta-analysis of gonorrhoea and chlamydia prevalence among men who have sex with men from 2000 to 2022.","authors":"Ella P Davies, Motoyuki Tsuboi, Jayne Evans, Jane Rowley, Eline L Korenromp, Tim Clayton, R Matthew Chico","doi":"10.1177/09564624251333489","DOIUrl":"10.1177/09564624251333489","url":null,"abstract":"<p><p>IntroductionWe conducted a global systematic review and meta-analysis of gonorrhoea and chlamydia among men who have sex with men (MSM) from 2000 to 2022.MethodsWe searched four databases to identify studies conducted between 1 January 2000 and 19 April 2022 that reported prevalence from aetiological assays. We extracted data, calculated point estimates, corrected and then pooled them using random-effects models. We stratified results by United Nations regions and conducted subgroup analyses established <i>apriori.</i>Results172 studies met our inclusion criteria, providing 387 prevalence data points from 57 countries. The overall pooled prevalence for gonorrhoea was 7.2% [95% CI: 6.0 to 8.5; 188 data points; <i>n</i> = 347,253] and for chlamydia was 9.9% (95% CI: 8.8 to 11.0; 190 data points; <i>n</i> = 342,799). For gonorrhoea, pooled prevalence between 2000 and 2010 was 5.0% (95% CI: 3.7 to 6.5; 89 data points; <i>n</i> = 78,557) compared to 9.3% (7.7-11.1; 99 data points; <i>n</i> = 268,696) between 2011 and 2022, <i>p</i> < 0.001. For chlamydia, pooled prevalence between 2000 to 2010 was 6.6% (95% CI: 5.4 to 7.9; 95 data points; <i>n</i> = 91,015) compared to 13.6% (12.0-15.2; 95 data points; <i>n</i> = 251,784) between 2011 and 2022, <i>p</i> < 0.001.ConclusionA holistic approach is needed to reduce the curable STIs burden among MSM.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"611-621"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bictegravir-emtrictabine-tenofovir alafenamide in combination with oxcarbazepine in a person living with HIV and viral load suppression.","authors":"Patricia Pecora Fulco, Megan Gray","doi":"10.1177/09564624251335146","DOIUrl":"10.1177/09564624251335146","url":null,"abstract":"<p><p>We describe a case of a person living with HIV (PWH) with concurrent use of bictegravir and oxcarbazepine. Concomitant use of these pharmacotherapy regimens is considered contraindicated. A review of the literature, therapeutic bictegravir drug concentration monitoring and viral load evaluations allowed the continued current pharmacotherapy prescription of these medications.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"664-666"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Philiph Tonui, Yan Tong, Omenge Orang'o, Kapten Muthoka, Peter Itsura, John Groopman, Sean Burke, Beverly Musick, Constantin Yiannoutsos, Aaron Ermel, Patrick J Loehrer, Darron R Brown
{"title":"Lack of HIV suppression is associated with plasma aflatoxin B1 in Kenyan women living with HIV and receiving anti-retroviral therapy.","authors":"Philiph Tonui, Yan Tong, Omenge Orang'o, Kapten Muthoka, Peter Itsura, John Groopman, Sean Burke, Beverly Musick, Constantin Yiannoutsos, Aaron Ermel, Patrick J Loehrer, Darron R Brown","doi":"10.1177/09564624251338598","DOIUrl":"10.1177/09564624251338598","url":null,"abstract":"<p><p>BackgroundAflatoxins are carcinogenic and immunosuppressive compounds found in Aspergillus-contaminated corn. Kenyan women living with HIV (WLWH) receiving antiretroviral therapy (ART) were studied to examine associations of aflatoxin exposure and HIV immune control.MethodsSixty WLWH were enrolled; 56 completed the Month-12 visit. Blood samples were collected for aflatoxin, CD4 cell counts and HIV viral load. Logistic regression and linear regression models were fitted to examine factors associated with (1) detectable HIV viral load, and (2) HIV viral load in copies/mL.ResultsAll WLWH were receiving ART (mean 9.9 years). Eight women (14.3%) had a detectable HIV viral load (mean 12,439 copies/mL). Aflatoxin B1 was detected in 23 of 56 WLWH (41.7%); 17 of 48 (35.4%) with an undetectable HIV viral load, and 6 of 8 (75.0%) with a detectable HIV viral load (<i>p</i> = 0.053). The mean plasma aflatoxin B1 concentration for all WLWH was 0.0403 pg/μL; 0.0341 pg/μL and 0.0771 pg/μL for WLWH with undetectable or detectable HIV viral loads, respectively (<i>p</i> = 0.039).ConclusionsAflatoxin B1 detection is associated with lack of HIV viral load suppression, defined as a detectable HIV viral load, among a cohort of Kenyan WLWH, all receiving ART. Studies are needed to determine the mechanisms involved.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"633-641"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of chancroid in a Spanish man returning from an endemic area.","authors":"Jorge N García-Pérez, Maider Arando","doi":"10.1177/09564624251343480","DOIUrl":"10.1177/09564624251343480","url":null,"abstract":"<p><p>A 64 year old cisgender man attended to our genito-urinary clinic with a 1 week history of a painful genital ulcer after travelling to Madagascar. On physical examination, we observed two small ulcers, each with a fibrinous base and erythematous borders, without associated lymphadenopathy. The initial diagnosis was a genital herpes outbreak. Thus, a seven-day course of Valaciclovir 500 mg twice daily orally was prescribed. An ulcer sample was collected for NAATs including <i>C.</i> <i>trachomatis L1-L3</i>, Herpes simplex virus 1 and 2, Varicella-zoster virus, <i>Treponema pallidum</i> and <i>Haemophilus ducreyi</i>. The ulcer NAATs was positive for <i>H.</i> <i>ducreyi</i>. Considering the result and the epidemiological background, diagnosis confirmed chancroid. Ceftriaxone 1 g STAT intramuscular was administered with subsequent improvement. Chancroid, caused by <i>H.</i> <i>ducreyi</i> is very rare in Europe. Its prevalence in STI clinics has varied from 0% to 0.5%. It must be suspected, especially in travellers to endemic countries in the first days of their return due to its short incubation period.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"676-677"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}