International Journal of STD & AIDS最新文献_第2页

Lack of HIV suppression is associated with plasma aflatoxin B1 in Kenyan women living with HIV and receiving anti-retroviral therapy. 在肯尼亚感染艾滋病毒并接受抗逆转录病毒治疗的妇女中，缺乏艾滋病毒抑制与血浆黄曲霉毒素B1有关。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-04-30 DOI: 10.1177/09564624251338598

Philiph Tonui, Yan Tong, Omenge Orang'o, Kapten Muthoka, Peter Itsura, John Groopman, Sean Burke, Beverly Musick, Constantin Yiannoutsos, Aaron Ermel, Patrick J Loehrer, Darron R Brown

{"title":"Lack of HIV suppression is associated with plasma aflatoxin B1 in Kenyan women living with HIV and receiving anti-retroviral therapy.","authors":"Philiph Tonui, Yan Tong, Omenge Orang'o, Kapten Muthoka, Peter Itsura, John Groopman, Sean Burke, Beverly Musick, Constantin Yiannoutsos, Aaron Ermel, Patrick J Loehrer, Darron R Brown","doi":"10.1177/09564624251338598","DOIUrl":"https://doi.org/10.1177/09564624251338598","url":null,"abstract":"BackgroundAflatoxins are carcinogenic and immunosuppressive compounds found in Aspergillus-contaminated corn. Kenyan women living with HIV (WLWH) receiving antiretroviral therapy (ART) were studied to examine associations of aflatoxin exposure and HIV immune control.MethodsSixty WLWH were enrolled; 56 completed the Month-12 visit. Blood samples were collected for aflatoxin, CD4 cell counts and HIV viral load. Logistic regression and linear regression models were fitted to examine factors associated with (1) detectable HIV viral load, and (2) HIV viral load in copies/mL.ResultsAll WLWH were receiving ART (mean 9.9 years). Eight women (14.3%) had a detectable HIV viral load (mean 12,439 copies/mL). Aflatoxin B1 was detected in 23 of 56 WLWH (41.7%); 17 of 48 (35.4%) with an undetectable HIV viral load, and 6 of 8 (75.0%) with a detectable HIV viral load (p = 0.053). The mean plasma aflatoxin B1 concentration for all WLWH was 0.0403 pg/μL; 0.0341 pg/μL and 0.0771 pg/μL for WLWH with undetectable or detectable HIV viral loads, respectively (p = 0.039).ConclusionsAflatoxin B1 detection is associated with lack of HIV viral load suppression, defined as a detectable HIV viral load, among a cohort of Kenyan WLWH, all receiving ART. Studies are needed to determine the mechanisms involved.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251338598"},"PeriodicalIF":1.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follmann's balanitis: An heterogeneous clinical manifestation of primary syphilis. 福尔曼balitis：原发性梅毒的异质临床表现。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-04-30 DOI: 10.1177/09564624251338657

Jorge Pérez Garcia, Patricia Álvarez-Lopez, Juliana Esperalba, Vicente Descalzo, Maider Arando

{"title":"Follmann's balanitis: An heterogeneous clinical manifestation of primary syphilis.","authors":"Jorge Pérez Garcia, Patricia Álvarez-Lopez, Juliana Esperalba, Vicente Descalzo, Maider Arando","doi":"10.1177/09564624251338657","DOIUrl":"https://doi.org/10.1177/09564624251338657","url":null,"abstract":"BackgroundSexually transmitted infections (STIs) rates have increased in the last two decades in Western world, including syphilis. Higher rates of syphilis lead to the emergence of atypical or less common manifestations like Follmann's balanitis. Follmann's balanitis is an atypical presentation of primary syphilis characterized as erythematous, erosive lesions on the glans penis.MethodsThe aim of the study is to describe the cases of the Follmann 's diagnosed in Vall d'Hebron-Drassanes STI Unit over 20 years (2003-2023). Retrospectively, the epidemiological, clinical and microbiological data were collected.ResultsIn total 20 cases of Follmann's balanitis were diagnosed. The clinical presentation was heterogeneous, with erosive balanitis being the most frequent presentation. Fifteen per cent had also a chancre and 50% presented with lymphadenopathy. Dark field microscopy and Treponema pallidum NAAT were positive in 41% and 92% respectively, and the median RPR titre was 1/4 (IQR 1/2-1/16).ConclusionsFollmann's balanitis is a rare presentation of primary syphilis which has to be suspected in case of erosive balanitis, especially in key populations as MSM or persons with previous STIs, where syphilis is more frequent.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251338657"},"PeriodicalIF":1.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attributes that influence testing decisions for sexually transmitted and blood-borne infections: A qualitative study among diverse people in Canada. 影响性传播和血液传播感染检测决策的属性：加拿大不同人群的定性研究。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-04-30 DOI: 10.1177/09564624251337595

M Elizabeth Snow, Mary H Berger, Alexander Ct Tam, Adam Easterbrook, Chidubem Ekpereamaka Okechukwu, Tima Mohammadi, Peter Hutchinson, Sean B Rourke, Aslam H Anis, Wei Zhang

{"title":"Attributes that influence testing decisions for sexually transmitted and blood-borne infections: A qualitative study among diverse people in Canada.","authors":"M Elizabeth Snow, Mary H Berger, Alexander Ct Tam, Adam Easterbrook, Chidubem Ekpereamaka Okechukwu, Tima Mohammadi, Peter Hutchinson, Sean B Rourke, Aslam H Anis, Wei Zhang","doi":"10.1177/09564624251337595","DOIUrl":"https://doi.org/10.1177/09564624251337595","url":null,"abstract":"BackgroundSexually transmitted and blood-borne infections (STBBIs) disproportionately affect key populations in Canada. For example, recent estimates suggested that the proportion of people living with hepatitis C is the highest among people who use injection drugs and that gay, bisexual and other men who have sex with men represent a high proportion of new cases of infectious syphilis. Understanding what STBBIs test users and potential testers perceive as important aspects of testing will help inform testing initiatives. We aimed to determine aspects of STBBI testing that are important to a diverse range of key populations in Canada.MethodsWe conducted qualitative interviews and focus groups with people from key populations (gay, bisexual, and other men who have sex with men; African, Caribbean, or Black individuals; Indigenous individuals; sex workers; people who use substances and injection drugs) and people who do not identify as a key population member. We conducted a thematic analysis.ResultsTwo major themes emerged: stigma and inequality, and journey into and through the healthcare system. Within the first theme, participants had diverse perspectives on how aspects of their identity interacted with willingness to seek testing. Within the second theme, participants discussed aspects of testing. Test costs, wait times, and testing accuracy were all viewed as important, but differing perspectives emerged about privacy of testing and receiving results, testing location, and who administers the test.ConclusionsParticipants' perspectives on STBBI testing and willingness to test were informed by their experiences and aspects of their identity.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251337595"},"PeriodicalIF":1.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dangers of naked sunbathing: Cutaneous larva migrans on the penis. 裸体日光浴的危险：阴茎上的皮肤幼虫迁移。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-04-28 DOI: 10.1177/09564624251336993

Stefano Veraldi, Italo Francesco Aromolo, Gianluca Nazzaro

引用次数: 0

A global meta-analysis of gonorrhoea and chlamydia prevalence among men who have sex with men from 2000 to 2022. 2000年至2022年全球男男性行为者淋病和衣原体患病率荟萃分析

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-04-21 DOI: 10.1177/09564624251333489

Ella P Davies, Motoyuki Tsuboi, Jayne Evans, Jane Rowley, Eline L Korenromp, Tim Clayton, R Matthew Chico

{"title":"A global meta-analysis of gonorrhoea and chlamydia prevalence among men who have sex with men from 2000 to 2022.","authors":"Ella P Davies, Motoyuki Tsuboi, Jayne Evans, Jane Rowley, Eline L Korenromp, Tim Clayton, R Matthew Chico","doi":"10.1177/09564624251333489","DOIUrl":"https://doi.org/10.1177/09564624251333489","url":null,"abstract":"IntroductionWe conducted a global systematic review and meta-analysis of gonorrhoea and chlamydia among men who have sex with men (MSM) from 2000 to 2022.MethodsWe searched four databases to identify studies conducted between 1 January 2000 and 19 April 2022 that reported prevalence from aetiological assays. We extracted data, calculated point estimates, corrected and then pooled them using random-effects models. We stratified results by United Nations regions and conducted subgroup analyses established apriori.Results172 studies met our inclusion criteria, providing 387 prevalence data points from 57 countries. The overall pooled prevalence for gonorrhoea was 7.2% [95% CI: 6.0 to 8.5; 188 data points; n = 347,253] and for chlamydia was 9.9% (95% CI: 8.8 to 11.0; 190 data points; n = 342,799). For gonorrhoea, pooled prevalence between 2000 and 2010 was 5.0% (95% CI: 3.7 to 6.5; 89 data points; n = 78,557) compared to 9.3% (7.7-11.1; 99 data points; n = 268,696) between 2011 and 2022, p < 0.001. For chlamydia, pooled prevalence between 2000 to 2010 was 6.6% (95% CI: 5.4 to 7.9; 95 data points; n = 91,015) compared to 13.6% (12.0-15.2; 95 data points; n = 251,784) between 2011 and 2022, p < 0.001.ConclusionA holistic approach is needed to reduce the curable STIs burden among MSM.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251333489"},"PeriodicalIF":1.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bictegravir-emtrictabine-tenofovir alafenamide in combination with oxcarbazepine in a person living with HIV and viral load suppression. 比替格拉韦-恩曲他滨-替诺福韦-阿拉那胺联合奥卡西平治疗艾滋病毒感染者和病毒载量抑制。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-04-15 DOI: 10.1177/09564624251335146

Patricia Pecora Fulco, Megan Gray

引用次数: 0

Post-acute sequelae of COVID-19 in people of Black ethnicities living with HIV in the United Kingdom. 英国黑人艾滋病毒感染者COVID-19急性后后遗症

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-04-14 DOI: 10.1177/09564624251334227

Zoe Ottaway, Lucy Campbell, Julie Fox, Fiona M Burns, Lisa Hamzah, Sarah Schoeman, David Price, Amanda Clarke, Sarah L Pett, Denis Onyango, Caroline Sabin, Robert F Miller, Frank A Post

{"title":"Post-acute sequelae of COVID-19 in people of Black ethnicities living with HIV in the United Kingdom.","authors":"Zoe Ottaway, Lucy Campbell, Julie Fox, Fiona M Burns, Lisa Hamzah, Sarah Schoeman, David Price, Amanda Clarke, Sarah L Pett, Denis Onyango, Caroline Sabin, Robert F Miller, Frank A Post","doi":"10.1177/09564624251334227","DOIUrl":"https://doi.org/10.1177/09564624251334227","url":null,"abstract":"BackgroundThe COVID-19 pandemic disproportionately affected people of Black ethnicities, however, there are limited data on the post-acute sequelae of COVID-19 infection in these populations, and none in those with HIV.MethodsWe conducted a cross-sectional study in people of Black ethnicities with HIV in the UK. Participants were assessed for functional impairment, frailty, respiratory symptoms, anxiety and depression; they were also asked to rate aspects of their physical and mental health on a scale from 1 (poor) to 10 (excellent), both at enrolment and prior to the pandemic. We report associations with COVID-19 history and recovery status.ResultsWe enrolled 183 participants between June 2021 and October 2022, 131 (72%) of whom reported COVID-19. A history of COVID-19 was associated with a reduced ability to carry out usual activities (OR 2.54 [1.03-6.21], p = 0.04), an increase in pain, tiredness and breathlessness, and overall decline in physical health. Of those with a history of COVID-19, 111 (85%) reported to have fully recovered. Those who had not fully recovered reported poorer functional status (p < 0.001) and had higher generalised anxiety scores (p = 0.02). Objective measures of physical function were similar in those who reported no COVID-19, COVID-19 with full recovery, and COVID-19 with incomplete recovery.ConclusionsIn this cohort of Black people with HIV, participants with a history of COVID-19 reported a reduced ability to carry out activities of daily living and various other health issues. Although most people reported full recovery from COVID-19, self-reported limitations in functional status and anxiety were common sequelae.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251334227"},"PeriodicalIF":1.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking barriers to PrEP access in Italy: The Florence STD center "model" for nationwide implementation. 打破意大利获得预防措施的障碍：佛罗伦萨性病中心全国实施的“模式”。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-04-14 DOI: 10.1177/09564624251333493

Luigi Pisano, Nicola Pimpinelli

引用次数: 0

A new era in HIV treatment: Evaluating the benefits of lenacapavir. HIV治疗的新时代：评估lenacapavir的益处。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-04-14 DOI: 10.1177/09564624251333499

Sinnha Kumari, Nikil Kumar, Muhammad Saad Khan

引用次数: 0

Prevention and management strategies of anal squamous cell carcinoma among men who have sex with men living with HIV. 与艾滋病毒感染者发生性行为的男性肛门鳞状细胞癌的预防和治疗策略。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-04-13 DOI: 10.1177/09564624251333035

Zhi Wang, Xudong Zhao, Wenchao Du, Xiaoliang Zhang, Xingxing Li, Linquan Wang

{"title":"Prevention and management strategies of anal squamous cell carcinoma among men who have sex with men living with HIV.","authors":"Zhi Wang, Xudong Zhao, Wenchao Du, Xiaoliang Zhang, Xingxing Li, Linquan Wang","doi":"10.1177/09564624251333035","DOIUrl":"https://doi.org/10.1177/09564624251333035","url":null,"abstract":"The incidence of anal squamous cell carcinoma (SCCA) has been rapidly increasing in recent years. The burden of the disease is expected to increase in the forthcoming years. Men who have sex with men living with HIV (MSMLWH) have a higher incidence of SCCA than the general population. The progression of SCCA usually develops from high risk human papillomavirus (HR-HPV) infection to high grade squamous intra-epithelial lesions (HSIL). HPV infection is highly prevalent in MSMLWH and is considered the most important risk factor for SCCA in MSMLWH. Although the prevalence worldwide is largely similar, the distribution of high-risk HPV genotypes varies. Education on sexuality and lifestyle, use of condoms, fixed sexual partner, effective antiretroviral therapy (ART), smoking cessation, and preventive male circumcision could reduce HPV infection in MSMLWH. Screening and treatment of HSIL have been widely applied to prevent SCCA, but divergence still exists in many studies. When treating HSIL, patients of different ages and risk factors need more consideration to develop standardized management strategies, especially for MSMLWH. Very few studies have examined the treatment of SCCA with MSMLWH. ART has dramatically changed the treatment of SCCA in MSMLWH. The safety and outcome of treatment are still primary concerns for MSMLWH. More studies in this field are necessary to develop treatment strategies for MSMLWH.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251333035"},"PeriodicalIF":1.4,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0