International Journal of STD & AIDS最新文献

{"title":"Exploring mpox vaccination uptake and tolerability among people living with HIV: A study in an infectious disease unit in Italy.","authors":"Samuele Gaggioli, Giuseppe Formica, Valentina Petrini, Alessandra Russo Krauss, Paola Corsi, Alessandro Di Felice, Costanza Fiorelli, Elisabetta Mantengoli, Costanza Malcontenti, Emanuela Francalanci, Giulia Modi, Michele Trotta, Seble Tekle Kiros, Elena Gazzarri, Nicoletta Zocco, Lorenzo Zammarchi, Alessandro Bartoloni, Filippo Lagi","doi":"10.1177/09564624251349888","DOIUrl":"https://doi.org/10.1177/09564624251349888","url":null,"abstract":"<p><p>BackgroundA live attenuated non-replicating vaccine (MVA-BN) is approved for immunization against mpox. We provide an overview of the uptake and tolerability of mpox vaccination among people living with HIV (PLWH) in a single centre in Italy and draw comparisons to individuals without HIV.MethodsWe retrospectively collected clinical data of people vaccinated with MVA-BN in a tertiary-level hospital in Florence, Italy. Baseline data were collected from pre-vaccination screening questionnaires; adverse events data were collected before the second dose through another dedicated questionnaire.ResultsWe vaccinated 332 subjects. Of them, 36.1% (<i>n</i> = 120) were PLWH, with higher median age, higher rate of previous smallpox vaccination and a higher proportion of transgender individuals compared to people without HIV. As for vaccine tolerability, subcutaneous administration was associated with significantly fewer adverse events than intradermal. There were no significant differences in tolerability between PLWH and individuals without HIV. Among people who did not complete the vaccine cycle, migrant and sex worker populations were disproportionately represented.ConclusionOur experience suggests that mpox vaccination has been accepted and well-tolerated in individuals with and without HIV. More work is needed to conduct immunization campaigns in marginalized populations such as migrants and sex workers.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251349888"},"PeriodicalIF":1.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"British Association for Sexual Health and HIV (BASHH) UK national guideline for the use of doxycycline post-exposure prophylaxis (DoxyPEP) for the prevention of syphilis, 2025.","authors":"John Saunders, Joseph Deering, Claire Dewsnap, Rachel Drayton, John Gilmore, Alison Grant, Dwayne-Wilson Hunt, Manik Kohli, Fiona Lyons, Hamish Mohammed, Phil Samba, Benjamin Weil, John White, Nicholas Medland, Helen Fifer","doi":"10.1177/09564624251352053","DOIUrl":"https://doi.org/10.1177/09564624251352053","url":null,"abstract":"<p><p>This guideline provides evidence-based recommendations for the use of doxycycline post exposure prophylaxis (doxyPEP) for the prevention of syphilis. DoxyPEP should be part of a comprehensive approach to the prevention of STIs, along with condom use, appropriate HIV prevention interventions, vaccination, STI testing, treatment and management, and appropriate risk reduction advice and psychological interventions if indicated.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352053"},"PeriodicalIF":1.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C increases acute myocardial infarction risk in people living with HIV: A systematic review and meta-analysis.","authors":"Thanathip Suenghataiphorn, Narisara Tribhuddharat, Pojsakorn Danpanichkul, Thitiphan Srikulmontri, Narathorn Kulthamrongsri","doi":"10.1177/09564624251348688","DOIUrl":"https://doi.org/10.1177/09564624251348688","url":null,"abstract":"<p><p>BackgroundHepatitis C virus (HCV) coinfection is common among people living with HIV (PLWH) and is associated with adverse outcomes. However, the specific association between HCV coinfection and the risk of acute myocardial infarction (AMI) in PLWH remains unclear. This systematic review and meta-analysis aims to clarify this relationship.MethodWe searched MEDLINE and EMBASE databases from inception to October 2024 for cohort studies comparing the incidence of AMI in PLWH with HCV coinfection versus PLWH without HCV coinfection (HIV mono-infection). We used the generic inverse variance method with a random-effects model to pool risk ratios (RRs) and 95% confidence intervals (CIs). Heterogeneity was assessed using the I² statistic. All statistical analyses were performed using Review Manager 5.4.ResultsSeven cohort studies, encompassing 94,664 participants (mean age 42 years, 83% male), met the inclusion criteria. HCV coinfection was associated with a significantly increased risk of AMI in PLWH (pooled RR = 1.25, 95% CI: 1.09, 1.44; I² = 18%; <i>p</i> < .001) compared to HIV mono-infection. A subgroup analysis restricted to type 1 AMI was not statistically significant (pooled RR = 1.03, 95% CI: 0.84, 1.26; <i>p</i> = .78).ConclusionsHCV coinfection is associated with a significantly increased risk of AMI in PLWH. Further research is needed to determine the pathophysiology of this relationship.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251348688"},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, symptomology, and correlates of curable sexually transmitted infections among pregnant women in Eastern Cape, South Africa.","authors":"Natalie G Shaetonhodi, Alex de Voux, Chibuzor M Babalola, Dvora Joseph Davey, Mandisa M Mdingi, Ranjana M S Gigi, Remco P H Peters, Freedom Mukomana, Jeffrey D Klausner, Andrew Medina-Marino","doi":"10.1177/09564624251347484","DOIUrl":"https://doi.org/10.1177/09564624251347484","url":null,"abstract":"<p><p>BackgroundCurable sexually transmitted infections (STIs) contribute to adverse maternal and neonatal outcomes. Syndromic management is standard care in South Africa. We evaluated prevalence, symptomology, and correlates of curable STIs, among pregnant women in Eastern Cape, South Africa.MethodsWe conducted a cross-sectional analysis using baseline data from a randomized controlled trial of pregnant women attending their first antenatal care visit at public clinics in Buffalo City Municipality (2021-2024). Participants were tested for <i>Chlamydia (C.) trachomatis</i>, <i>Neisseria (N.) gonorrhoeae</i>, <i>Trichomonas (T.) vaginalis</i> using GeneXpert point-of-care tests and for syphilis using Alere Determine TP rapid test. Symptoms were self-reported and clinically-observed. Adjusted prevalence ratios were estimated using Poisson regression models with robust standard errors.ResultsAmong 1491 participants (median age: 28 years (IQR: 24-33); gestational age: 13 weeks (IQR: 8-18); HIV prevalence: 30%), STI prevalence was 27.6% (95% CI: 25.3-29.9): <i>C. trachomatis</i> 14.7%, <i>N. gonorrhea</i> 5%, <i>T. vaginalis</i> 10.2%, syphilis 3.4%. Women with HIV had higher STI prevalence (32.8% vs 25.3%, <i>p</i> = .003), particularly for <i>T. vaginalis</i> (17% vs 7.3%, <i>p</i> < .001); 20.1% of women with C<i>. trachomatis</i>, <i>N. gonorrhea</i>, and/or <i>T. vaginalis</i> were symptomatic, and 63% of symptomatic women tested STI-negative. Younger age, lower education, multiple sex partners and unknown HIV-serostatus of partners were associated with increased STI prevalence.ConclusionWe observed a high prevalence of STIs, particularly among women with HIV, with many asymptomatic cases; emphasizing the need for integrated point-of-care testing to ensure timely treatment, reduce antibiotic overuse, and improve maternal and neonatal outcomes.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251347484"},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with sexually transmitted reinfections, number of sexual partners and condom use among previously infected young people.","authors":"Isobel Landray, James R Carpenter, Sima Berendes, Melissa J Palmer, Caroline Free","doi":"10.1177/09564624251348693","DOIUrl":"https://doi.org/10.1177/09564624251348693","url":null,"abstract":"<p><p>BackgroundSexually transmitted infections (STIs) are prevalent in young people. Digital interventions promoting safer sexual behaviours are low-cost and scalable. We use data from a randomised controlled trial of one such potential intervention (safetxt) to investigate factors associated with STI reinfection and risky sexual behaviours.MethodsWe use data from 6248 young people with STIs recruited from 92 UK sexual health clinics. Multivariable logistic regression models were developed with the outcomes: reinfection, condom use at last sex and number of sexual partners (≤1 or >1) at 1 year. A pre-specified variable selection process assessed effects of sociodemographic and sexual behaviour factors measured at trial baseline.ResultsFactors associated with reinfection included sexuality, ethnicity, baseline diagnosis of gonorrhoea and chlamydia, index of multiple deprivation, whether the participant and/or the last new partner tested before sex. Risk factors for condom use at last sex and number of sexual partners included sexuality and education level. The multivariable models had good calibration but poor discrimination.ConclusionsIn this large sample with good representation across social and ethnic groups, we identified patient characteristics associated with higher risk of reinfection. Improved understanding of factors associated with reinfections and higher-risk sexual behaviours can aid development of interventions.Trial RegistrationISRCTN64390461.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251348693"},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of sleep problems and associated factors in older people living with HIV: A latent class analysis.","authors":"Aodi Zhang, Wen Cheng, Bolin Yang, Jibiao Chen, Hanlu Yin, Jing Gu, Zhuping Xu, Peng Xu, Xiaojun Meng","doi":"10.1177/09564624251349594","DOIUrl":"https://doi.org/10.1177/09564624251349594","url":null,"abstract":"<p><p>BackgroundTo identify sleep subtypes and associated factors in older people living with HIV (PLWH).MethodsA cross-sectional study was conducted to recruit older PLWH in Wuxi, China. Sleep quality was assessed using the Pittsburgh Sleep Quality Index. Latent class analysis was employed to examine sleep patterns, and logistic regression was performed to analyze associated factors.ResultsIn total, 830 participants were recruited with a median age of 60.9 years (IQR 55.4-67.9), of whom 79.0% were male, and 25.4% had sleep disorders. Three sleep patterns were identified: optimal sleep (48.3%), poor sleep (39.9%), and bad sleep (11.8%). Compared to the optimal sleep group, housing area (OR = 0.67, 95% CI: 0.50-0.91), social media app usage (OR = 0.57, 95% CI: 0.37-0.87), and years living with HIV (OR = 1.49, 95% CI: 1.05-2.10) were significantly associated with poor sleep. In contrast, age (OR = 1.89, 95% CI: 1.12-3.20), sex (OR = 1.94, 95% CI: 1.15-3.27), exercise frequency (OR = 1.64, 95% CI: 1.02-2.63), polypharmacy (OR = 0.27, 95% CI: 0.14-0.52), and years living with HIV (OR = 1.85, 95% CI: 1.11-3.07) were significantly associated with bad sleep.ConclusionsSignificant heterogeneities were observed across different sleep patterns among older PLWH. Potential associated factors should be considered when developing targeted strategies to improve sleep quality in this population.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251349594"},"PeriodicalIF":1.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the hidden epidemic: A scoping review of sexually transmitted diseases in Southeast Asia.","authors":"Nazri Che Dom, Rahmat Dapari, Mohamad Adzrin Harith Mohamad Syahriman, Adam Adha Mohd Sukri, Nur Leiza Azwa Kamarudin, Nur Shuhada Aqilah Ahmad Bakhtiar, Nur Syabila Alya Khairi, Nopadol Precha, Wan Shahriman Yushdie Wan Yusoff","doi":"10.1177/09564624251349598","DOIUrl":"https://doi.org/10.1177/09564624251349598","url":null,"abstract":"<p><p><b>Background:</b> Sexually transmitted diseases (STDs) pose a significant global health challenge, with Southeast Asia bearing a disproportionately high burden due to socio-demographic vulnerabilities, disparities in healthcare access, and prevailing cultural stigmas. Despite growing research interest in the region, a comprehensive synthesis of disease burden, risk factors, and intervention strategies remains limited.<b>Objectives:</b> This study aimed to systematically review research trends, study populations, and pathogen distributions of STDs in Southeast Asia to identify evidence gaps and inform future policy and intervention strategies.<b>Methods:</b> A systematic literature search was conducted using Scopus, Web of Science, and PubMed databases in accordance with PRISMA guidelines. Eligible studies were those focusing on STDs in Southeast Asia and included high-risk populations such as men who have sex with men (MSM), sex workers, youth, heterosexual men and women, transgender individuals, and people living with HIV (PLHIV). The review encompassed key STDs including HIV/AIDS, syphilis, gonorrhea, chlamydia, HPV, trichomoniasis, and hepatitis B & C.<b>Results:</b> From 2,867 records, 58 studies met the inclusion criteria. HIV/AIDS was the most frequently studied STD (80%), while bacterial STDs and transgender populations were significantly underrepresented. Most studies employed cross-sectional designs (60%), with few longitudinal or interventional studies. Geographically, research was concentrated in Malaysia, Thailand, and Singapore, with limited representation from Cambodia, Vietnam, and Indonesia.<b>Discussion:</b> The findings underscore substantial research gaps, particularly in bacterial STDs, studies involving heterosexual and transgender populations, and the application of intervention-based designs. Inconsistencies in reporting standards and population definitions further limit the comparability of findings across studies.<b>Conclusion:</b> This review highlights the need for more inclusive and methodologically diverse research on STDs in Southeast Asia. Future efforts should prioritize standardized data collection frameworks, improved surveillance systems, and greater emphasis on intervention studies to strengthen evidence-based public health responses in the region.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251349598"},"PeriodicalIF":1.4,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary syphilis presenting with elevated CA19-9: A report of two cases.","authors":"Toshiya Nakashima, Hiroshi Ito, Koki Kikuchi","doi":"10.1177/09564624251348680","DOIUrl":"https://doi.org/10.1177/09564624251348680","url":null,"abstract":"<p><p>Syphilis is known for its diverse and often deceptive clinical manifestations, yet its potential to elevate tumor markers such as carbohydrate antigen 19-9 (CA19-9) remains underrecognized. We report two cases of secondary syphilis, each presenting with markedly elevated CA19-9 levels in the absence of malignancy. Both patients exhibited cholestatic liver enzyme elevations, and neither had structural abnormalities in the pancreaticobiliary system. In both cases, CA19-9 levels normalized following appropriate antibiotic treatment for syphilis. These cases suggest that systemic inflammation, hepatocellular injury with regenerative changes, and epithelial damage associated with syphilitic hepatitis may contribute to transient CA19-9 elevation.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251348680"},"PeriodicalIF":1.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vespasiano Gonzaga, founder of Sabbioneta, and his Renaissance disease.","authors":"Gianluca Nazzaro","doi":"10.1177/09564624251347419","DOIUrl":"https://doi.org/10.1177/09564624251347419","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251347419"},"PeriodicalIF":1.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmission of gonorrhea from the oral cavity to the rectal tract: A systematic review.","authors":"Yuri Garcia Dutra Souza, Yan Rocha Neves, Valéria de Oliveira, Luiz Eduardo de Almeida, Mabel Miluska Suca Salas","doi":"10.1177/09564624251347457","DOIUrl":"https://doi.org/10.1177/09564624251347457","url":null,"abstract":"<p><p>BackgroundThe antimicrobial resistance of Neisseria gonorrhoeae and the high prevalence of asymptomatic extragenital infections are a worldwide concern. This research investigated whether gonorrhea can be transmitted from the oral cavity to the anorectal tract among men who have sex with men.<b>Purpose</b>The aim of this research is to find plausible relationships regarding the probability of gonococcal transmission from the oral cavity to the anorectal tract among MSM.<b>Research Design</b>A research question was defined using the P.I.C.O. strategy (population, intervention or exposure, comparison and outcome), where the target population is MSM, the intervention is exposure to contaminated oral cavity/saliva, the control is the absence of exposure, and the outcome is the acquisition of GC. The eligibility criteria included observational studies involving men who have sex with men, regardless of sexual orientation, aged 16 or older, screened for oropharyngeal and rectal gonorrhea, and examining the role of oral fluids in transmission. Studies involving partners previously diagnosed with urogenital gonorrhea or reporting consistent condom use during receptive penoanal sex were excluded to avoid urethral-to-anorectal transmission bias.<b>Study Sample</b>The databases employed were PubMed, Scopus, Web of Science, EBSCO, SciELO, and the Virtual Health Library (VHL). A total of 383 studies were identified, however, only 6 were included.<b>Data Collection and/or Analysis</b>According to the Newcastle-Ottawa Scale (NOS), two studies were \"very good,\" two \"good,\" and two \"satisfactory\". Most studies described a complete methodology according to Strengthening the Reporting of Observational studies in Epidemiology (STROBE).<b>Results</b>Differences in diagnostic methods, methodologies, and variables limited the findings. While the results do not confirm transmission from the oral cavity to the anorectal tract, they suggest its possibility. Further research is needed to better understand this transmission route.<b>Conclusions</b>Transmissibility of gonorrhea from oropharyngeal via to the anorectal tract cannot be totally establish. However, evidence suggested the existence of this gonorrhea transmission. The fact that men with rectal gonorrhea continue to appear, even in contexts of condom use or the absence of receptive penoanal sex, brings the importance of cases monitoring and the establishment of preventive strategies.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251347457"},"PeriodicalIF":1.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}