International Journal of STD & AIDS最新文献

{"title":"Gastrointestinal <i>Escherichia coli</i> in men who have sex with men: A systematic review.","authors":"Jim Abi Frem, Annie Russell, Colin Fitzpatrick, Deborah Williams, Daniel Richardson","doi":"10.1177/09564624241306847","DOIUrl":"https://doi.org/10.1177/09564624241306847","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review aimed to explore any demographic, biological and behavioural characteristics of men who have sex with men (MSM) with diarrhoeagenic <i>E.coli</i>.</p><p><strong>Design/methods: </strong>We searched MEDLINE, EMBASE, and CINAHL for manuscripts published to March 2024. One author screened manuscript abstracts; two authors independently conducted a full text review. We only included primary data on gastrointestinal <i>E.coli</i> in MSM. Risk of bias was assessed independently by two authors using the Joanna Briggs Institute tools. This review was registered on PROSPERO(CRD42023455321).</p><p><strong>Results: </strong>Eleven manuscripts (cross-sectional studies (<i>n</i> = 8), case-series (<i>n</i> = 1), case-control study (<i>n</i> = 1), longitudinal study (<i>n</i> = 1)) from Europe (<i>n</i> = 7) Australia (<i>n</i> = 2), USA (<i>n</i> = 2) including 983 MSM with gastrointestinal <i>E.coli</i> published between 2014-2023 were included in this review. Demographic factors (living with HIV, using HIV-PrEP, using dating apps and working as airline crew, group sex, non-regular (casual) sexual partners); behavioural factors (non-regular sexual partners, non-condom use, oro-anal sex, penile-anal sex, use of sex toys, insertive and receptive fisting, scat play); and infection factors (co-infection with <i>Chlamydia trachomatis</i> including LGV, <i>Neisseria gonorrhoeae</i>, <i>Treponema pallidum</i>, hepatitis C, other enteric pathogens [<i>Shigella</i> spp. <i>Giardia duodenalis, Entamoeba histolytica</i>, hepatitis A and intestinal spirochaetosis]) were observed in MSM with <i>E. coli</i>. Antimicrobial resistance (extended spectrum beta-lactamase and quinolone resistance) was described in MSM with <i>E.coli</i>.</p><p><strong>Conclusion: </strong>We have highlighted demographic, behavioral and infection factors observed in MSM with <i>E.coli</i> suggesting sexual transmissibility. These data provide insight for future clinical guidelines, public health control strategies and research.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241306847"},"PeriodicalIF":1.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HI Acquired palmoplantar keratoderma in an immunocompromised patient: A case report.","authors":"Daniel Z Villarreal-Martínez, Mayra A Reyes-Soto, Leslie M Garza-García, Jair A Valdez-Zertuche, Daniela López-Quintero, Sonia Chavez-Alvarez, Jorge Ocampo-Candiani, Alejandra Villarreal-Martínez","doi":"10.1177/09564624241307732","DOIUrl":"https://doi.org/10.1177/09564624241307732","url":null,"abstract":"<p><p>Syphilis, known for its capacity to mimic various diseases, has seen rising incidence, particularly in adolescents, men who have sex with men (MSM), and individuals with HIV. Palmoplantar keratoderma (PPK), a rare manifestation of secondary syphilis, poses diagnostic challenges due to its resemblance to other conditions. We report the case of a 42-year-old man living with HIV presenting with acquired PPK, characterized by hyperkeratotic plaques on the palms and soles, alongside syphilitic roseola. Histopathology confirmed psoriasiform dermatitis with spirochetes. The patient received weekly intramuscular benzathine penicillin G, leading to significant clinical improvement without relapse. This case underscores the importance of recognizing atypical infectious presentations in individuals living with HIV and highlights the need for careful differential diagnosis in acquired PPK cases.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241307732"},"PeriodicalIF":1.4,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, knowledge and readiness of clinicians to deliver 4CMenB vaccines for <i>Neisseria gonorrhoeae</i> prevention.","authors":"Lucy Rabuszko, Sarah Stuart-George, Deborah Williams, Daniel Richardson","doi":"10.1177/09564624241306157","DOIUrl":"https://doi.org/10.1177/09564624241306157","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241306157"},"PeriodicalIF":1.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Admission diagnoses and outcomes among hospitalized people living with HIV during pre-COVID-19, COVID-19 and post-COVID-19 pandemic periods.","authors":"Pattarapoom Panutat, Thana Khawcharoenporn","doi":"10.1177/09564624241304849","DOIUrl":"https://doi.org/10.1177/09564624241304849","url":null,"abstract":"<p><strong>Background: </strong>Data on the impact of coronavirus disease 2019 (COVID-19) on hospitalization and outcomes among people living with HIV (PLHIV) are limited.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted among PLHIV hospitalized during the pre-COVID-19, COVID-19, and post-COVID-19 periods.</p><p><strong>Results: </strong>Of the 310 PLHIV included, 117, 125 and 68 were admitted during the three periods, respectively and 115 (37%) were newly diagnosed with HIV. Median CD4 cell counts and proportions of those with antiretroviral therapy (ART) adherence rates ≥95% at admission were different between the three periods [(206, 97 and 138 cells/mm³ (<i>p</i> = .02) and 97%, 89% and 100% (<i>p</i> = .06), respectively]. Of the 310 PLHIV, admission diagnoses were non-AIDS-related (62%) and AIDS-related (38%). Most of the non-AIDS-related diagnoses were infections other than opportunistic infections (OIs) (40%) while OIs were the most common for AIDS-related diagnoses (88%). The types of admission diagnoses were comparable between the three periods. Hospital mortality rates were 10%, 13% and 16% during pre-COVID-19, COVID-19 and post-COVID-19 periods, respectively (<i>p</i> = .80). By multivariable analysis, intensive care unit admission, underlying malignancy, monthly income less than $USD 400, and admission CD4 less than 50 cells/mm³ were independently associated with hospital mortality.</p><p><strong>Conclusions: </strong>Although admission during COVID-19 pandemic period was not associated with increased mortality, we observed the impact of the pandemic on the lower CD4 cell count and ART adherence at admission among hospitalized PLHIV. Interventions to improve early care engagement, ART adherence, and close monitoring for those with identified mortality risks are needed for better HIV care, especially during pandemics.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241304849"},"PeriodicalIF":1.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Let's get PrEP'd\" - A pilot service evaluation of the LVNDR health digital pre-exposure prophylaxis pathway for HIV prevention.","authors":"Joshua S Wells, Jennifer Ching, Araxie Boyadjian, Christopher El Badaoui","doi":"10.1177/09564624241303815","DOIUrl":"https://doi.org/10.1177/09564624241303815","url":null,"abstract":"<p><strong>Background: </strong>Despite the availability of PrEP, 2023 data have demonstrated an increase in new HIV diagnoses. LGBTQ + individuals are disproportionately affected by HIV. PrEP access is crucial but limited due to high demand on sexual health services. Additional modalities of PrEP access may help to address this unmet need. LVNDR Health, a digital solution for LGBTQ + care, sought to evaluate its PrEP pathway.</p><p><strong>Methods: </strong>We conducted a retrospective cross-sectional service evaluation of users accessing the LVNDR digital PrEP pathway between December 2022-April 2023. Operational data (e.g., appointment attendance) were derived from the clinical dashboard. Service-user feedback (e.g., service experience) was sought using a bespoke questionnaire. Descriptive statistics are reported for socio-demographic information. Non-parametric between-group analyses are reported.</p><p><strong>Results: </strong>In total, 90 users completed the end-to-end pathway and received PrEP. Average time for pathway completion was 2.7 weeks. A survey response rate of 71.0% was achieved. Users reported significantly higher service satisfaction, inclusivity, and accessibility, compared to their most recent experience accessing PrEP (<i>p</i> < .01). Up to 89% of users strongly agreed they would switch to a digital PrEP service if made available.</p><p><strong>Conclusion: </strong>Digital PrEP shows acceptability among LGBTQ + populations. More research is needed to assess scalability, digital equity, and cost-effectiveness.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241303815"},"PeriodicalIF":1.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated initiation of antiretroviral therapy by virtual health in service members newly diagnosed with HIV infection.","authors":"Anatole Openshaw, Jason Okulicz, Joseph Yabes","doi":"10.1177/09564624241301467","DOIUrl":"https://doi.org/10.1177/09564624241301467","url":null,"abstract":"<p><strong>Objectives: </strong>Delays in HIV antiretroviral therapy (ART) have been associated with HIV disease progression and forward transmission. We evaluated the effectiveness of an accelerated ART virtual protocol (VP) for active duty (AD) members with incident HIV diagnosis.</p><p><strong>Methods: </strong>Under the traditional protocol (TP), service members stationed worldwide were evaluated in-person at Brooke Army Medical Center (BAMC) and received comprehensive HIV care. In February 2020, a VP was adopted to initiate HIV care at the local base. Chart reviews were conducted to obtain patient demographics and clinical data. Continuous variables were compared using 2-tailed t tests, categorical variables were evaluated with Fisher's exact or Chi squared tests.</p><p><strong>Results: </strong>Time from HIV notification to ART initiation was significantly shorter with the VP compared to the TP (15 days vs 25 days; <i>p</i> = <0.05). The VP had a shorter time to viral suppression compared to the TP (96 days [SD ± 86] compared to 269 days [SD ± 300], <i>p</i> = <0.05).</p><p><strong>Conclusions: </strong>The VP was associated with a shorter time to HIV specialty evaluation, ART initiation, and viral suppression. The use of virtual health protocols for other time sensitive medical interventions and/or for access to limited specialties should be considered as these may improve quality of care.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241301467"},"PeriodicalIF":1.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated IL-10 serum levels are associated with slower serological response following syphilis treatment during pregnancy.","authors":"Martyna Kiolbasa, Agnieszka Kotlarz, Konrad Kaminiów, Maciej Pastuszczak","doi":"10.1177/09564624241303816","DOIUrl":"10.1177/09564624241303816","url":null,"abstract":"<p><strong>Background: </strong>Approximately 50% of pregnant individuals treated for syphilis do not achieve a decline in non-treponemal titers by delivery. The serological response in pregnant persons is significantly slower compared to non-pregnant individuals, with unclear pathogenesis and clinical significance. This study aimed to determine the association between the host immune response and serological outcome in pregnant individuals with syphilis.</p><p><strong>Methods: </strong>Twenty-four females with early syphilis, including 14 pregnant individuals, were included. Pro-inflammatory and regulatory cytokines (IFN-γ, TNF-α, IL-4, IL-1β, IL-10, TGF-β) were measured before treatment and 6 months after penicillin injection.</p><p><strong>Results: </strong>The median time to serological cure was 5 months for pregnant individuals and 2 months for non-pregnant females. Pregnant individuals had significantly higher serum levels of IL-10 and TGF-β at baseline and at 6 months post-treatment compared to non-pregnant individuals (<i>p</i> < .05).</p><p><strong>Conclusions: </strong>A robust regulatory immune response to syphilis may be associated with a slower serological response to therapy during pregnancy.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241303816"},"PeriodicalIF":1.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"How well do we know our patients?\": Further validation of a complexity rating scale for HIV.","authors":"Kim Begley, Don Smith, Handan Wand, Derek Chan, Virginia Furner, Melissa Louise Kelly, Patrick McGrath, Ruth Hennessy, Anthony Price, Lia Purnomo, Bruce Hamish Bowden, Shiraze M Bulsara","doi":"10.1177/09564624241279604","DOIUrl":"10.1177/09564624241279604","url":null,"abstract":"<p><strong>Background: </strong>Despite advances in the management and treatment of HIV, identifying risks for disengagement are essential to maximize positive outcomes. The current study investigated the validity of the Clinical Complexity Rating Scale for HIV (CCRS-HIV), a risk-prediction tool, by assessing agreement between patient and clinician scores of patient complexity.</p><p><strong>Methods: </strong>207 patients completed the patient version of the CCRS-HIV (CCRS-HIV^P), and six Attending Medical Officers (AMOs) caring for those individuals completed the original clinician version (CCRS-HIV^C). Kappa statistics, sensitivity and specificity were used to assess patient-clinician agreement.</p><p><strong>Results: </strong>Patient-clinician agreement was highest for problematic crystal methamphetamine use (86%), polypharmacy (84%) and other physical health concerns (67%). Cut-offs of 40 and 45 for the total CCRS-HIV score were identified as most appropriate, with high sensitivity (79.31% and 76.0% respectively).</p><p><strong>Conclusions: </strong>Overall agreement between the clinician and patient complexity scores was high. These findings provide further evidence of the validity of the scale. The study demonstrates that the unique role of AMOs at the center contributes to them knowing their patients well, allowing them to manage and refer when required for interdisciplinary care which likely contributes to their ongoing engagement in care and may account for the high level of agreement.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1112-1119"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"British Association of Sexual Health and HIV (BASHH) UK guidelines for the management of syphilis in pregnancy and children 2024.","authors":"Margaret Kingston, Janet Wilson, Sarah Dermont, Helen Fifer, Koon Chan, Hermione Lyall, Paddy McMaster, Emma Shawkat, Alex Thomas-Leech","doi":"10.1177/09564624241280387","DOIUrl":"10.1177/09564624241280387","url":null,"abstract":"<p><p>This new guideline details the specific management of syphilis in pregnancy and in children. It is to be used in clinical practice alongside the BASHH UK guidelines for the management of syphilis 2024.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"1161-1173"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health services delivery factors affecting HIV retesting among pregnant women at 34 weeks gestation in Saboba District, Northern region, Ghana.","authors":"Williams Azumah Abanga, Desmond Klu, Maxwell Dery, Iddrisu Fusheini, Salifu Dwomoh, Chrysantus Kubio, Harry Kwami Tagbor","doi":"10.1177/09564624241303819","DOIUrl":"https://doi.org/10.1177/09564624241303819","url":null,"abstract":"<p><strong>Background: </strong>Vertical transmission of HIV is a major global public health issue, particularly due to maternal HIV acquisition during pregnancy, challenges in enrolling pregnant women living with HIV into antiretroviral therapy programmes, and loss to follow-up. The factors influencing HIV retesting in pregnant women with an initial HIV-negative results are understudied. The study examined health service delivery factors affecting HIV retesting among pregnant women.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in six health facilities in the Saboba District in 2023. Pregnant women who initially tested HIV-negative and were attending antenatal clinics at 34 weeks gestation or later were randomly selected. Data was analyzed using Stata version 15.0. Logistic regression was used to examined the health service factors affecting HIV retesting at a 0.05 significant level.</p><p><strong>Results: </strong>Out of 445 pregnant women initially HIV-negative, only 21.1% were retested at 34 weeks gestation. Pregnant women receiving antenatal care at health centers were less likely to be retested [aOR = 0.34; CI: 0.14-0.84], while those who spent less time during ANC were more likely to retest [aOR = 2.58; CI: 1.33-5.01].</p><p><strong>Conclusions: </strong>Improvement in HIV retesting requires reproductive health units to develop strategies to enhance coverage and reduce waiting times at health centers could encourage more pregnant women to retest for HIV.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624241303819"},"PeriodicalIF":1.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}