International Journal of STD & AIDS最新文献_第3页

Loss of control of herpes suppression following bariatric surgery. 减肥手术后疱疹抑制失控。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-07-01 Epub Date: 2024-06-25 DOI: 10.1177/09564624241264584

Shyam Samraj, Kimberley Olasoji, Raj Patel

引用次数: 0

Sickle cell trait, APOL1 risk allele status and chronic kidney disease among ART-experienced adults living with HIV in northern Nigeria. 尼日利亚北部接受过抗病毒治疗的成年艾滋病病毒感染者中的镰状细胞性状、APOL1 危险等位基因状态和慢性肾病。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-07-01 Epub Date: 2024-06-24 DOI: 10.1177/09564624241262397

Abdurrahman Abdulhamid, Bryan E Shepherd, Usman J Wudil, Chelsea Van Wyk, Faisal S Dankishiya, Nafiu Hussaini, C William Wester, Muktar H Aliyu

{"title":"Sickle cell trait, APOL1 risk allele status and chronic kidney disease among ART-experienced adults living with HIV in northern Nigeria.","authors":"Abdurrahman Abdulhamid, Bryan E Shepherd, Usman J Wudil, Chelsea Van Wyk, Faisal S Dankishiya, Nafiu Hussaini, C William Wester, Muktar H Aliyu","doi":"10.1177/09564624241262397","DOIUrl":"10.1177/09564624241262397","url":null,"abstract":"BackgroundWe sought to determine the prevalence of sickle cell trait (SCT) and apolipoprotein-1 (APOL1) risk variants in people living with HIV (PLWH) in Nigeria, and to establish if SCT and APOL1 high-risk status correlate with estimated glomerular filtration rate (eGFR) and/or prevalent chronic kidney disease (CKD).MethodsBaseline demographic and clinical data were obtained during three cross-sectional visits. CKD was defined as having an eGFR<60 mL/min/1.73 m2. We collected urine specimens to determine urine albumin-creatine ratio and blood samples for sickle cell genotyping, APOL1 testing, and for creatinine/cystatin C assessment. The associations between SCT, APOL1 genotype, and eGFR/CKD stages/CKD were investigated using linear/ordinal logistic/logistic regression models, respectively.ResultsOf 2443 participants, 599 (24.5%) had SCT, and 2291 (93.8%) had a low-risk APOL1 genotype (0 or 1 risk variant), while 152 (6.2%) had high-risk genotype (2 allele copies). In total, 108 participants (4.4%) were diagnosed with CKD. In adjusted analyses, SCT was associated with lower eGFR (adjusted mean difference [aMD]= -2.33, 95% CI -4.25, -0.42), but not with worse CKD stages, or increased odds of developing CKD. Participants with the APOL1 high risk genotype were more likely to have lower eGFR (aMD= -5.45, 95% CI -8.87, -2.03), to develop CKD (adjusted odds ratio [aOR] = 1.97, 95% CI: 1.03, 3.75), and to be in worse CKD stages (aOR = 1.60, 95% CI: 1.12, 2.29) than those with the low-risk genotype. There was no evidence of interaction between SCT and APOL1 genotype on eGFR or risk of CKD.ConclusionOur findings highlight the multifaceted interplay of genetic factors in the pathogenesis of CKD in PLWH.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"655-663"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acceptability, usability, and user experiences of an online postal self-sampling approach for HIV and STI testing in Belgium: Test2Know. 可接受性、可用性和用户体验的在线邮政自我抽样方法艾滋病毒和性传播感染检测在比利时：Test2Know。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-07-01 Epub Date: 2025-05-15 DOI: 10.1177/09564624251342616

Irith De Baetselier, Corinne Herrijgers, Fien Vanroye, Birgit Baudry, Tim Lebacq, Jacob Verschueren, Vicky Cuylaerts, Chris Kenyon, Maartje van Frankenhuijsen, Thibaut Vanbaelen, Kristien Wouters, Dorien Van den Bossche, Tom Platteau

{"title":"Acceptability, usability, and user experiences of an online postal self-sampling approach for HIV and STI testing in Belgium: Test2Know.","authors":"Irith De Baetselier, Corinne Herrijgers, Fien Vanroye, Birgit Baudry, Tim Lebacq, Jacob Verschueren, Vicky Cuylaerts, Chris Kenyon, Maartje van Frankenhuijsen, Thibaut Vanbaelen, Kristien Wouters, Dorien Van den Bossche, Tom Platteau","doi":"10.1177/09564624251342616","DOIUrl":"10.1177/09564624251342616","url":null,"abstract":"BackgroundOnline postal self-sampling (OPSS) for HIV/STI improves testing access and coverage. We assessed the acceptability, usability, and user experiences of the \"Test2Know\" (T2K) OPSS platform in Flanders, Belgium, to inform further implementation.MethodsEligible users completed a risk-assessment to determine infections (HIV, syphilis, chlamydia, gonorrhoea, hepatitis C) and anatomical sites for testing. Self-collected samples were mailed to the laboratory, and results were communicated via the platform. Users completed surveys on acceptability, usability and overall user experience.ResultsOf 131 individuals who received a kit; 98 (74.8%) returned samples. 62.2% were male, 27.6% were men who had exclusively sex with men, and the median age was 29 years. Nearly 43% had never been tested for HIV or did not recall previous testing. 9 (9.2%) tested positive for an STI, all men; 7/9 reported sex exclusively with men, and 2/9 had never tested for HIV. No HIV or HCV infections were detected. Usability and acceptability were 89.2% and 83.3% respectively, nearly 90% would reuse and recommend the platform. However, 45.4% preferred a mixed testing approach due to blood collection challenges.ConclusionsOPSS is highly acceptable and reaches individuals at risk for STI. Further research should explore sustainable integration into Belgian healthcare.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"642-648"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding barriers to HIV pre-exposure prophylaxis initiation among men who have sex with men in Sindh, Pakistan. 了解巴基斯坦信德省男男性行为者开始进行艾滋病毒暴露前预防的障碍。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-07-01 Epub Date: 2025-05-21 DOI: 10.1177/09564624251344419

Rab Nawaz Samo, Muhammad Shahid Jamil, Umar Riaz, Kanwal Mustafa, Syed Faisal Mahmood

{"title":"Understanding barriers to HIV pre-exposure prophylaxis initiation among men who have sex with men in Sindh, Pakistan.","authors":"Rab Nawaz Samo, Muhammad Shahid Jamil, Umar Riaz, Kanwal Mustafa, Syed Faisal Mahmood","doi":"10.1177/09564624251344419","DOIUrl":"10.1177/09564624251344419","url":null,"abstract":"BackgroundPre-exposure prophylaxis (PrEP) is a highly effective intervention to prevent HIV acquisition. Oral PrEP was introduced for men who have sex with men (MSM) in Sindh province of Pakistan in June 2022, yet the uptake remains suboptimal. Here we present an assessment of barriers to PrEP uptake among MSM accessing HIV prevention services in Sindh.MethodsWe conducted a cross-sectional survey among MSM clients attending HIV prevention services from community-based organizations in Sindh province. Those who consented to participate were administered a paper-based questionnaire by providers to collect barriers to uptake of PrEP.ResultsWe enrolled 742 MSM between November 2023 and May 2024. Among enrolled clients, 149 (20.1%) agreed to initiate PrEP, while 593 (79.9%) refused to initiate PrEP. Among those who refused PrEP, fear of stigma and discrimination at facilities (430, 72.5%) and fear of side effects (416, 70.2%) were the leading reported barriers to PrEP initiation, followed by lack of time to attend the facilities (325, 54.8%), low risk perception (\"I have no risk of HIV\" [273, 46.0%] and \"I am healthy\" [265, 44.7%]), difficulty in taking medicine daily (263, 44.4%), transportation issue (229, 38.6%), out of pocket expenses (166, 28.0%), and using condoms during sex (97, 16.4%) as major barriers to PrEP initiation.ConclusionThe results highlight a need for addressing stigma and discrimination in healthcare settings, raising awareness about HIV risk factors, removing structural barriers to access and offering differentiated client-centered services to remove structural barriers to PrEP uptake.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"649-654"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attributes that influence testing decisions for sexually transmitted and blood-borne infections: A qualitative study among diverse people in Canada. 影响性传播和血液传播感染检测决策的属性：加拿大不同人群的定性研究。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-07-01 Epub Date: 2025-04-30 DOI: 10.1177/09564624251337595

M Elizabeth Snow, Mary H Berger, Alexander Ct Tam, Adam Easterbrook, Chidubem Ekpereamaka Okechukwu, Tima Mohammadi, Peter Hutchinson, Sean B Rourke, Aslam H Anis, Wei Zhang

{"title":"Attributes that influence testing decisions for sexually transmitted and blood-borne infections: A qualitative study among diverse people in Canada.","authors":"M Elizabeth Snow, Mary H Berger, Alexander Ct Tam, Adam Easterbrook, Chidubem Ekpereamaka Okechukwu, Tima Mohammadi, Peter Hutchinson, Sean B Rourke, Aslam H Anis, Wei Zhang","doi":"10.1177/09564624251337595","DOIUrl":"10.1177/09564624251337595","url":null,"abstract":"BackgroundSexually transmitted and blood-borne infections (STBBIs) disproportionately affect key populations in Canada. For example, recent estimates suggested that the proportion of people living with hepatitis C is the highest among people who use injection drugs and that gay, bisexual and other men who have sex with men represent a high proportion of new cases of infectious syphilis. Understanding what STBBIs test users and potential testers perceive as important aspects of testing will help inform testing initiatives. We aimed to determine aspects of STBBI testing that are important to a diverse range of key populations in Canada.MethodsWe conducted qualitative interviews and focus groups with people from key populations (gay, bisexual, and other men who have sex with men; African, Caribbean, or Black individuals; Indigenous individuals; sex workers; people who use substances and injection drugs) and people who do not identify as a key population member. We conducted a thematic analysis.ResultsTwo major themes emerged: stigma and inequality, and journey into and through the healthcare system. Within the first theme, participants had diverse perspectives on how aspects of their identity interacted with willingness to seek testing. Within the second theme, participants discussed aspects of testing. Test costs, wait times, and testing accuracy were all viewed as important, but differing perspectives emerged about privacy of testing and receiving results, testing location, and who administers the test.ConclusionsParticipants' perspectives on STBBI testing and willingness to test were informed by their experiences and aspects of their identity.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"622-632"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of and outcomes of pregnancy in adolescents with perinatally-acquired HIV infection in Southern Africa. 南部非洲围产期获得性艾滋病毒感染青少年怀孕的发生率和结果。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-06-27 DOI: 10.1177/09564624251352066

Nyasha Veronica Dzavakwa, Molly Chisenga, Hilda Banda-Mabuda, Cassandra Namukonda, Lackson Kasonka, Tsitsi Bandason, Nicol Redzo, Hilda Angela Mujuru, Katharina Kranzer, Victoria Simms, Rashida A Ferrand

{"title":"Incidence of and outcomes of pregnancy in adolescents with perinatally-acquired HIV infection in Southern Africa.","authors":"Nyasha Veronica Dzavakwa, Molly Chisenga, Hilda Banda-Mabuda, Cassandra Namukonda, Lackson Kasonka, Tsitsi Bandason, Nicol Redzo, Hilda Angela Mujuru, Katharina Kranzer, Victoria Simms, Rashida A Ferrand","doi":"10.1177/09564624251352066","DOIUrl":"https://doi.org/10.1177/09564624251352066","url":null,"abstract":"BackgroundThe scale-up of antiretroviral therapy (ART) has enabled more children living with HIV to reach adolescence and become sexually active. We investigated pregnancy incidence and outcomes among adolescents with perinatally acquired HIV enrolled in a multi-country trial of vitamin D and calcium carbonate supplementation (VITALITY; PACTR202009897660297).MethodsBetween February and November 2021, 842 adolescents aged 11-19 years from Zambia and Zimbabwe on ART for at least 6 months were enrolled. Pregnancies occurring during 96 weeks of follow-up (February 2021-October 2023) were identified through self-report or testing. Pregnancy incidence rate was calculated among post-menarche participants using survival time analysis.ResultsThirty-five adolescents (median age 18, range 13-22) became pregnant, 21 in Zambia, 14 in Zimbabwe. Overall pregnancy incidence was 4.6 per 100 person-years (95% CI 3.3-6.4), higher in those ≥15 years (6.8 per 100 person-years, 95% CI 4.8-9.7). Three pregnancies ended in miscarriage; 32 resulted in live births. Of the 30 adolescents with live births and available data, 26 (86.7%) infants were tested for HIV at birth: 24 were HIV-negative, two had unknown results. Twenty-nine received HIV prophylaxis. At 6 weeks, 19/30 infants were retested for HIV: 16 were HIV-negative. Twenty-one of 32 pregnant adolescents were in school at conception, and 4 (19.0%) returned post-pregnancy. Overall, 23/33 (69.7%) started contraception, a median of 9 weeks after delivery/miscarriage.ConclusionPregnancy incidence is high among adolescents with HIV, especially older adolescents. While prevention of vertical HIV transmission is effective, education re-integration and timely contraception uptake remain limited.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352066"},"PeriodicalIF":1.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circinate balanitis in HLA B27 spondyloarthrithis: A report of two cases. HLA - B27型脊柱炎：附2例报告。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-06-24 DOI: 10.1177/09564624251352051

Ammu Shanmughan, Betsy Ambooken, Jijith Krishnan, Vayapurath Gangadharan Binesh

{"title":"Circinate balanitis in HLA B27 spondyloarthrithis: A report of two cases.","authors":"Ammu Shanmughan, Betsy Ambooken, Jijith Krishnan, Vayapurath Gangadharan Binesh","doi":"10.1177/09564624251352051","DOIUrl":"https://doi.org/10.1177/09564624251352051","url":null,"abstract":"Circinate balanitis is a characteristic mucocutaneous lesion commonly associated with reactive arthritis (ReA), previously described as Reiter's disease. It typically presents alongside other ReA symptoms, including urethritis, conjunctivitis, and arthritis, but can occasionally occur as an isolated finding. We report two cases of circinate balanitis occurring in patients with HLA B27-positive spondyloarthritis, without the classical triad of reactive arthritis. A 32-year-old male presented with recurrent erosions on the glans penis for 2 years, with a history of HLA B27-positive spondyloarthritis. He was on treatment with tofacitinib, deflazacort, and sulfasalazine. A skin biopsy from the scrotum confirmed the diagnosis of psoriasis. MRI spine and sacrum showed anterior syndesmophyte formation and right-sided sacroillitis. The final diagnosis was circinate balanitis in association with HLA B27-positive psoriatic spondyloarthritis. A 41-year-old male presented with recurrent erosions on the glans penis for 4 years with history of HLA B27 positivity, and ankylosing spondyloarthritis. The biopsy from the glans penis showed squamous hyperplasia. MRI spine and pelvis was suggestive of inflammatory spondyloarthropathy of the cervical, dorsal and lumbar spine with bilateral sacroilitis. The final diagnosis was circinate balanitis with primary ankylosing spondylitis. Both cases highlight the diagnostic challenge of distinguishing between different forms of spondyloarthritis in the presence ofcircinate balanitis.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352051"},"PeriodicalIF":1.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Necrotic skin reaction following the administration of intramuscular injections of long-acting cabotegravir/rilpivirine and alternatively-sourced testosterone. 肌肉注射长效卡替格拉韦/利匹韦林和替代来源睾酮后的皮肤坏死反应。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-06-24 DOI: 10.1177/09564624251352050

Shahid Bukhari, Ruth Byrne, Yemi Daramola, Christina Antoniadi, Marta Boffito

引用次数: 0

HIV self-testing knowledge, attitudes, and acceptance in New York City. 纽约市艾滋病毒自我检测的知识、态度和接受程度。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-06-24 DOI: 10.1177/09564624251355833

Abhishek R Mogili, Omi Singh, Parth Dhruve, Anna Martens, Rachel Kasdin, Sarah Weihl, Bashar Zaidat, Matthew Erdos, Beverly Forsyth

{"title":"HIV self-testing knowledge, attitudes, and acceptance in New York City.","authors":"Abhishek R Mogili, Omi Singh, Parth Dhruve, Anna Martens, Rachel Kasdin, Sarah Weihl, Bashar Zaidat, Matthew Erdos, Beverly Forsyth","doi":"10.1177/09564624251355833","DOIUrl":"https://doi.org/10.1177/09564624251355833","url":null,"abstract":"BackgroundHIV testing is a critical strategy for prevention. During the COVID-19 pandemic, many community-based organizations (CBOs) offering free HIV testing were unable to provide in-person services. Innovations like free HIV Self-Testing (HIVST), provided a solution and can be done outside clinical settings, help address barriers such as cost, availability, and stigma. However, HIVST uptake remains low in resource-rich settings like the US, and best practices for integrating it into existing HIV services are still undetermined.MethodsGay Men's Health Crisis (GMHC) partnered with the NYC Health Department (NYCDOHMH) to distribute free HIVST kits. From April to February 2023, survey data was collected to assess client barriers and HIVST's role in a differentiated service model.ResultsThe survey had 201 participants, 151 in the in-person testing group and 50 in the at-home group. The study revealed that 34.7% of in-person respondents were unaware that HIVST was an option. In-person testers were less likely to trust an HIVST test result compared with an in-person test result, and all testers were more likely to choose the same method they previously used. Nevertheless, there was interest in HIVST: 24% of in-person testers indicated interest in HIVST for their next test.ConclusionsHIVST can supplement in-person testing in settings with fragmented healthcare systems and limited continuity of care. Respondents demonstrated low awareness but notable interest in HIVST, suggesting its potential to improve access, particularly for populations more likely to use it than in-person options. Further research is needed to optimize HIVST implementation within existing service models.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251355833"},"PeriodicalIF":1.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycoplasma genitalium treatment strategies in the era of significant macrolide resistance: Findings from a multi-centre audit in Northwest England. 大环内酯类药物耐药时代的生殖支原体治疗策略：来自英格兰西北部多中心审计的结果。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-06-24 DOI: 10.1177/09564624251353583

Izuchukwu Ezeh, Bethany Harrison, Eva Klesnik-Edwards, Alisha Varia, Emily Clarke, Vincent Lee

{"title":"Mycoplasma genitalium treatment strategies in the era of significant macrolide resistance: Findings from a multi-centre audit in Northwest England.","authors":"Izuchukwu Ezeh, Bethany Harrison, Eva Klesnik-Edwards, Alisha Varia, Emily Clarke, Vincent Lee","doi":"10.1177/09564624251353583","DOIUrl":"https://doi.org/10.1177/09564624251353583","url":null,"abstract":"IntroductionAzithromycin is first-line for uncomplicated Mycoplasma genitalium (Mgen) treatment in UK and European guidelines, however the rates of azithromycin resistance have increased significantly in recent years leading to higher rates of treatment failure. This study aims to review the disease epidemiology to guide service improvement.MethodsWe undertook a retrospective case note review of 1036 persons treated for Mgen over 1067 Mgen-related attendances. We obtained data on demographics, site(s) of infection, antibiotic resistance, treatment regimen received and results of test of cure.Results71.1% (n = 759) patients received the recommended first-line regimen of doxycycline and azithromycin. Moxifloxacin is the recommended first-line management for macrolide-resistant or complicated infection. 15% (n = 155) patients received moxifloxacin alone as first-line treatment, and 6.9% (n = 72) patients received doxycycline and moxifloxacin dual therapy. 72.9% (n = 753) samples were successfully tested for macrolide resistance. Of these, 55.5% (n = 418) showed macrolide resistance. 20.6% (n = 7) showed fluoroquinolone resistance.ConclusionsResistance data show a macrolide resistance rate of 55.5% across our region, and at least 1 in 10 persons were inappropriately screened for Mgen. We propose a multi-pronged approach which includes strict adherence to testing criteria, local resistance testing, resistance-guided management as well as innovative approaches to improve test of cure rates.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251353583"},"PeriodicalIF":1.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0