International Journal of STD & AIDS最新文献

{"title":"Changes in bacterial sexually transmitted infections among men who have sex with men using pre-exposure prophylaxis in West Java, Indonesia.","authors":"Martha G Normallairy, Nadia Hanum, Miasari Handayani, Pratiwi Wikaningtyas, Armina Padmasawitri, Mawar N Pohan, Tarinanda A Putri, Fani F Rakhmat, Dwi S Anggiani, Nurhalina Afriana, Endang Lukitosari, Bagus R Prabowo, Rudi Wisaksana","doi":"10.1177/09564624251379714","DOIUrl":"https://doi.org/10.1177/09564624251379714","url":null,"abstract":"<p><p>BackgroundWe assessed STI incidence, prevalence, and associated factors, and changes in sexual behaviours among MSM using HIV pre-exposure prophylaxis (PrEP) in West Java province, Indonesia.MethodsThe Indonesia PrEP pilot program was a prospective, real-world implementation study providing oral daily or event-driven PrEP among key populations (KPs) in Indonesia. Participants completed baseline and three-monthly follow-up visits between 2021 and 2023, providing data on HIV tests, sexual behaviours, and changes in STIs.Results311 MSM were included in the analyses (median age 26.95, 54.34% chose D-PrEP, 16.40% had a history of STIs). During follow-up, STI prevalence increased, from 8.57% at month-three (M3) to 12.5% at M12. The STI incidence rate was 15.4/100 person-years [PYs] (9.78-23.16; 23 new STIs over 149 PYs). Multiple sexual partners and condomless last sex decreased, while inconsistent condom use increased. History of STIs before PrEP initiation (age-adjusted odds ratio [aOR] 5.02, 2.21-11.39, <i>p < 0.001</i>), condom use at last sex (aOR 3.24, 1.07-9.80, <i>p</i> = 0.037), and not having ≥2 sexual partners (aOR 0.12, 0.03-0.47, <i>p</i> = 0.002) were associated with STIs.ConclusionsAmong MSM in West Java, an increase in the prevalence of STIs was observed, but not exceeding the prevalence before PrEP initiation, which was related to sexual behaviours.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251379714"},"PeriodicalIF":1.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional analysis of doxyPEP use and outcomes in Michigan, United States.","authors":"Christen J Arena, Nathan A Everson, Rachel M Kenney, Indira Brar, Smitha Gudipati, Nicholas Yared, Susan L Davis, Michael P Veve","doi":"10.1177/09564624251379701","DOIUrl":"https://doi.org/10.1177/09564624251379701","url":null,"abstract":"<p><p><b>Background:</b> In 2024, national guidance was issued for doxycycline post-exposure prophylaxis (doxy-PEP) to prevent bacterial sexually transmitted infections (STIs). The study purpose was to evaluate doxy-PEP use in patients with increased risk of STI exposure at a large, urban health system. <b>Methods:</b> IRB-exempt study of adult patients with clinic encounters for increased risk of STI exposure and testing for <i>N. gonorrhoeae</i>, <i>C. trachomatis</i>, and <i>T. pallidum</i> from 01/01/2023-31/10/2024. Patients were identified using ICD-10 code Z20.XX and STI testing. Doxy-PEP prescription utilization was evaluated after a dedicated doxy-PEP order was implemented with appropriate patient counseling instructions. The primary outcome was the proportion of doxy-PEP prescriptions utilized in at-risk patients; secondary outcomes were utilization of the dedicated doxy-PEP order and abnormal STI testing within 3-months of the doxy-PEP prescription. <b>Results:</b> 4234 high-risk sexual patient encounters were documented; 7.37% of patients received a doxy-PEP prescription. Of these, 29.5% were ordered utilizing a dedicated doxy-PEP order. Most patients who received a doxy-PEP prescription were Black (96.6%), men (92.6%), with a median (IQR) age of 29 (24-37) years, and had private/commercial insurance (42%). One patient had abnormal syphilis testing within 3-months of doxy-PEP prescription. <b>Conclusions:</b> These findings highlight doxy-PEP underutilization and the need for broader provider engagement and advanced antimicrobial stewardship interventions.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251379701"},"PeriodicalIF":1.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multidisciplinary approach to people living with HIV dropping out from treatment-results from a HIV clinic in Portugal.","authors":"Francisca Oliveira, Francisca Bartilotti Matos, Ana Gorgulho, Cristóvão Figueiredo, Tiago Teixeira, Maria Mendes, Rita Carvalho, Maria José Monteiro, Raquel Couto, Daniel Coutinho, Cristina Pelicano, Amélia Magna Marques, Luís Malheiro","doi":"10.1177/09564624251379715","DOIUrl":"https://doi.org/10.1177/09564624251379715","url":null,"abstract":"<p><p>BackgroundAdherence to HIV care is pivotal for achieving viral suppression, preventing viral transmission, and improving health outcomes. Despite advancements in antiretroviral therapy, many people living with HIV (PLHIV) are disengaged from care, compromising treatment effectiveness.MethodsA retrospective cohort study was conducted on 81 episodes of care dropout at a Portuguese hospital between 2018 and 2024. A multidisciplinary team (physicians, nurses, social workers, and mental health professionals) implemented a structured program to reengage patients. Demographic, clinical, and socioeconomic data were collected at baseline and after 6 months.Results79% percent of the participants returned to care, with 68% resuming antiretroviral therapy. Although most patients achieved improved viral load suppression after returning, 27% were lost to follow-up after 6 months. Foreign-born individuals were associated with a lower likelihood of re-engagement. Common barriers include financial hardship, limited social support, and unaddressed mental health needs.ConclusionsA multidisciplinary approach effectively reconnected PLHIV to care and achieved enhanced virological outcomes. However, persistent socioeconomic and psychosocial challenges can lead to repeated disengagement. Long-term, targeted interventions, particularly for vulnerable groups, are required to sustain retention and ensure improved HIV management and overall patient well-being.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251379715"},"PeriodicalIF":1.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Effectiveness of Prevention of Mother-to-Child Transmission (PMTCT) programs: A case study of Federal Medical Centre, Asaba.","authors":"Ibukun Jacob Akinkunmi, Ayodapo Oluwadare Jegede, Ekedegwa Daniel Apeh, Uzuazoraro Michael Otuaga, Francis Ugoeze, Adesuwa Queen Aigbokhaode, Sylvia Ifeoma Obu, Evangeline Natalie Enaike, Efe Omoyibo, Victor Osiatuma, Samuel Okwuchukwu Ilikannu, Emwinloghosa Kenneth Guobadia, Benjamin Agbamudia, Johnson Eleojo Odaudu, Kate Akinkunmi","doi":"10.1177/09564624251377214","DOIUrl":"https://doi.org/10.1177/09564624251377214","url":null,"abstract":"<p><p>BackgroundMother-to-Child Transmission (MTCT) of HIV continues to be a critical public health issue, particularly in high-prevalence regions. This study examines the rates of MTCT in relation to antenatal booking, parity, antiretroviral (ARV) use, delivery mode, CD4 counts, and infant feeding practices.MethodsA retrospective cross-sectional study was conducted at the Federal Medical Centre, Asaba, Nigeria, involving pregnant women living with HIV attending the Prevention of Mother-to-Child Transmission (PMTCT) program. Data on demographics, antenatal booking, ARV use, delivery mode, CD4 count, and infant feeding were collected. Ethical approval was obtained from the hospital's ethics committee. MTCT rates were analysed based on these variables.ResultsMTCT rates dropped from 1.2% in 2018 to 0% in 2019, with an overall rate of 0.7%. Early antenatal booking and ARV adherence were critical in reducing MTCT. Vaginal delivery with ARV use showed lower MTCT rates than emergency caesarean sections. Higher MTCT rates were associated with CD4 counts below 200 cells/mm³, emphasizing the importance of early ART initiation. Exclusive breastfeeding with ARV prophylaxis was the most effective practice.ConclusionThe PMTCT program at FMC Asaba significantly reduced MTCT rates, highlighting the importance of early booking, ARV adherence, and appropriate delivery methods in improving maternal-child health in high HIV prevalence areas.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251377214"},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of four sexually transmitted pathogens and risk factors related to oral, vaginal, or anal intercourse among informal female sex workers from Tshwane, South Africa, 2022.","authors":"Avhammbudzi Leah Nemarude, Maphoshane Nchabeleng, Barbara Elizabeth de Villiers, Marcelle Le Roux","doi":"10.1177/09564624251363651","DOIUrl":"https://doi.org/10.1177/09564624251363651","url":null,"abstract":"<p><p>BackgroundFemale sex workers (FSWs) are at high risk for sexually transmitted infections (STIs). This study estimated the prevalence of STIs caused by <i>Neisseria gonorrhoeae</i> (NG), <i>Chlamydia</i> <i>trachomatis</i> (CT), <i>Mycoplasma</i> <i>genitalium</i> (MG), and <i>Trichomonas</i> <i>vaginalis</i> (TV) and identified factors related to oral, vaginal, or anal intercourse among FSWs in informal settings in Tshwane, South Africa.MethodsSamples were collected from 200 FSWs aged 18 and older in Pretoria who engaged in transactional sex. Participants completed a questionnaire on demographics, sexual history, and HIV testing. Three swabs (rectal, oral, and endocervical) from each participant were tested for NG, CT, MG, and TV.ResultsOf the 200 participants, 53 (26.5%) had at least one infection. Of these infections, the most common site of infection was genital (100 %), followed by the rectum (45.3 %), and pharynx (20.8 %). CT and TV were detected in 24 (12.0%) participants, while NG and MG were found in 20 (10.0%) participants. Most of the infected FSWs (32/53) had one sexually transmitted pathogen, while 21 (40%) had multiple STIs. Substance use was significantly associated with the presence of an STI.ConclusionThis study reveals a high burden of STIs among FSWs, highlighting pathogen prevalence at genital and extragenital sites. These findings underscore the need for targeted STI control interventions for high-risk groups like FSWs in South Africa.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251363651"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the outbreaks: The enduring psychological burden of recurrent symptomatic genital herpes - A prospective cohort study.","authors":"Sharang Gupta, Dimple Chopra","doi":"10.1177/09564624251376077","DOIUrl":"https://doi.org/10.1177/09564624251376077","url":null,"abstract":"<p><p>BackgroundGenital herpes, primarily caused by herpes simplex virus type 2 (HSV-2), is a chronic sexually transmitted infection with significant psychosocial implications. While cross-sectional studies have documented elevated depression, anxiety, and stigma among affected individuals, longitudinal data on the psychological burden of recurrent outbreaks remain scarce. In this study, recurrent genital herpes was defined as laboratory-confirmed HSV-2 infection with ≥2 symptomatic recurrences in the preceding year, and diagnosis was confirmed using polymerase chain reaction (PCR) from lesion swabs and/or type-specific serology at the initial episode; subsequent recurrences were diagnosed clinically with virological confirmation in a subset.ObjectivesThis study aimed to prospectively evaluate the longitudinal psychological burden of recurrent genital herpes, including depression, anxiety, stigma, and quality of life (QoL), and to identify modifiable risk factors influencing these outcomes.MethodsA prospective cohort study was conducted at a tertiary healthcare center in Punjab from January 2023 to December 2024. Participants included 100 adults with recurrent HSV-2 (≥2 outbreaks/year) and 100 matched controls. Clinical and psychological outcomes were assessed at baseline, 6, 12, and 24 months using validated tools such as the Hospital Anxiety and Depression Scale (HADS), STIGMA Scale for Herpes, and Herpes Quality of Life (HQoL) Questionnaire. Data on suppressive versus episodic antiviral therapy use, adherence measured by both self-report (MMAS-8) and pharmacy refill records, and relationship status (single, partnered, or in a serodiscordant relationship) were also collected. Statistical analyses included repeated measures ANOVA and multivariate regression.ResultsParticipants with recurrent HSV-2 exhibited higher baseline depression (29% vs 8%, <i>p</i> < .001) and anxiety (mean HADS: 11.2 vs 7.5, <i>p</i> < .001) compared to controls. Over 12 months, stigma (STIGMA mean: 38.2 vs 22.7, <i>p</i> < .001) and sexual distress (FSDS mean: 24.1 vs 15.8, <i>p</i> < .001) remained elevated in cases. Frequent outbreaks (≥5/year), low antiviral adherence, female gender, being in a serodiscordant relationship, and lack of social support independently predicted worse psychological outcomes (<i>p</i> < .01). Social support (MSPSS ≥60) was associated with improved QoL (<i>p</i> = .003).ConclusionsRecurrent genital herpes imposes a persistent psychological burden, particularly among individuals with frequent outbreaks, those in serodiscordant relationships and inadequate social support. Asymptomatic HSV-2-positive individuals and those on effective suppressive therapy demonstrated lower anxiety and stigma scores, suggesting a protective role of virological control. Integrated care models combining antiviral therapy with mental health interventions are needed to address stigma, gender disparities, and QoL impairments in this population.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251376077"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genital verruciform xanthoma: A rare differential to genital warts.","authors":"Alan Tang, Ann Williams","doi":"10.1177/09564624251374231","DOIUrl":"https://doi.org/10.1177/09564624251374231","url":null,"abstract":"<p><p>Verruciform xanthoma is a rare, benign mucocutaneous growth, usually seen in the oral cavity, but uncommonly also seen on genital skin. It presents as a flat or raised skin lesion, varying in colour with an irregular surface. These lesions can mimic stigmata of sexually transmitted infections such HPV-genital warts, condyloma latum or cause concern for inflammatory or malignant conditions, with histopathology being crucial for diagnosis and to avoid anxiety or invasive procedures. Underlying cause of these lesions remains uncertain, but no link to HPV has been identified. We present an 89 year old male referred to the sexual health service for concern of genital wart, despite low risk sexual history. Following removal and analysis to ensure non-malignant, the patient has been well since, with no recurrence.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251374231"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence meets HIV education: Comparing three large language models on accuracy, readability, and reliability.","authors":"Özge Eren Korkmaz, Burcu Açıkalın Arıkan, Selda Sayın Kutlu, Figen Kaptan Aydoğmuş, Nurbanu Sezak","doi":"10.1177/09564624251372369","DOIUrl":"https://doi.org/10.1177/09564624251372369","url":null,"abstract":"<p><p>BackgroundThis study compares three large language models (LLMs) in answering common HIV questions, given ongoing concerns about their accuracy and reliability in patient education.MethodsModels answered 63 HIV questions. Accuracy (5-point Likert), readability (Flesch-Kincaid, Gunning Fog, Coleman-Liau), and reliability (DISCERN, EQIP) were assessed.ResultsClaude 3.7 Sonnet showed significantly higher accuracy (4.54 ± 0.44) compared to ChatGPT-4o (4.29 ± 0.49) and Gemini Advanced 2.0 Flash (4.31 ± 0.50) (<i>p</i> < .001). ChatGPT-4o had lower accuracy in disease definition, follow-up, and transmission routes, while Gemini Advanced 2.0 Flash performed poorly in daily life and treatment-related questions. Readability analyses indicated ChatGPT-4o produced the most accessible content according to Flesch-Kincaid and Coleman-Liau indices, whereas Claude 3.7 Sonnet was most comprehensible by Gunning Fog standards. Gemini Advanced 2.0 Flash consistently generated more complex texts across all readability measures (<i>p</i> < .001). Regarding reliability, Claude 3.7 Sonnet achieved \"good\" quality on DISCERN, while others were rated \"moderate\" (<i>p</i> = .059). On EQIP, Claude 3.7 Sonnet (median 61.8) and ChatGPT-4o (55.3) were classified as \"good quality with minor limitations,\" whereas Gemini Advanced 2.0 Flash (41.2) was rated \"low quality\" (<i>p</i> = .049).ConclusionsClaude 3.7 Sonnet is preferable for accuracy and reliability, while ChatGPT-4o offers superior readability. Selecting LLMs for HIV education should consider accuracy, readability, and reliability, emphasizing regular assessment of content quality and cultural sensitivity.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251372369"},"PeriodicalIF":1.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual presentation of sclerosing lymphangitis of the penis with large ulcerations.","authors":"Noureddine Litaiem, Yosr Daoud, Faten Zeglaoui","doi":"10.1177/09564624251375872","DOIUrl":"https://doi.org/10.1177/09564624251375872","url":null,"abstract":"<p><p>Sclerosing lymphangitis of the penis (SLP) is a rare, benign condition typically presenting as a cord-like swelling. We report an unusual case of SLP in a 75-year-old circumcised man with marked penile edema and deep ulcerations. STI screening was negative. After 2 weeks of sexual abstinence and local care, the ulcerations healed, revealing the characteristic SLP cord. The penile swelling resolved completely after 2 months. This presentation is unique due to the patient's age and the prominent edema and ulcerations, suggesting these features may indicate a severe clinical form of SLP that only manifests its typical appearance after the initial acute phase resolves.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251375872"},"PeriodicalIF":1.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-evaluating STI prophylaxis following sexual assault: The role of DoxyPEP.","authors":"Hasan Mirza, Clare Fowler, Suneeta Soni","doi":"10.1177/09564624251374151","DOIUrl":"10.1177/09564624251374151","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251374151"},"PeriodicalIF":1.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}