International Journal of STD & AIDS最新文献

{"title":"The characteristics of men who have sex with men with <i>Blastocystis</i>: A systematic review.","authors":"Sophie Ettinger, John C Castle, Julian Robinson, Nicolas Pinto-Sander, Daniel Richardson","doi":"10.1177/09564624251349910","DOIUrl":"https://doi.org/10.1177/09564624251349910","url":null,"abstract":"<p><p>Objective<i>Blastocystis</i> is an enteric parasite which can cause gastrointestinal symptoms and may be sexually transmissible in men who have sex with men (MSM). This review aimed to explore the characteristics of MSM with <i>Blastocystis</i>.MethodFive bibliographical databases (CINAHL, EMBASE, MEDLINE, EMCARE, Cochrane-central) were searched for manuscripts which explored the characteristics of MSM with <i>Blastocystis</i> written in English, French or Spanish in October 2024. Following the initial search, duplicates were removed, and two authors independently conducted a full text review and risk of bias assessment using the Joanna Briggs Institute toolkits. Narrative data were synthesised to generate themes. The protocol was registered on PROSPERO(ID:CRD42024582946).ResultsFourteen manuscripts were included in this review; from Australia (<i>n</i> = 2), Spain (<i>n</i> = 2), Denmark (<i>n</i> = 2), USA (<i>n</i> = 2), UK(<i>n</i> = 1), Italy (<i>n</i> = 1), France (<i>n</i> = 1), Germany (<i>n</i> = 1), Canada (<i>n</i> = 1) & China (<i>n</i> = 1) published between 1988 and 2022. The manuscripts were case-reports (<i>n</i> = 2), case-series (<i>n</i> = 1) and cross-sectional studies (<i>n</i> = 11) and included 693 MSM who tested positive for <i>Blastocystis.</i> The majority of MSM in this review were living with HIV which either represents a biological, a behavioural (surrogate) characteristic or a confounding association. This review also highlighted demographic (being asymptomatic), behavioural (multiple sexual partners, recent (tropical) travel, oral-anal sex) and infection (co-infection with STI [<i>N</i>. <i>gonorrhoeae, C</i>. <i>trachomatis</i>], co-infection with other sexually transmissible enteric pathogens [<i>Salmonella spp., Campylobacter</i> spp.<i>, E.coli, E</i>. <i>histolytica, G</i>. <i>duodenalis, Cryptosporidium</i> spp.], co-infection with intestinal spirochaetosis<i>,</i> co-infection with a non-pathogenic enteric parasite) characteristics of MSM who tested positive for <i>Blastocystis.</i>ConclusionThis review serves as a resource for future public health control strategies, clinical guidelines and research to understand the sexual transmissibility of <i>Blastocystis</i> in MSM.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251349910"},"PeriodicalIF":1.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Chlamydia trachomatis</i> infections among men who have sex with men and transgender women attending four community-based clinics in Thailand, 2019-2021.","authors":"Jutatip Sillabutra, Sarika Pattanasin, Wachiraporn Wanichnopparat, Akarin Hiransuthikul, Sutthi Jareinpituk, Sujittra Suriwong, Nittaya Phanuphak, Pratana Satitvipawee","doi":"10.1177/09564624251352058","DOIUrl":"https://doi.org/10.1177/09564624251352058","url":null,"abstract":"<p><p>Background<i>Chlamydia trachomatis</i> (CT) infections are prevalent and often asymptomatic. Point-of-Care (PoC) tests offer a diagnostic option. We described the incidence and predictors of CT infection using secondary data collected from men who have sex with men (MSM) and transgender women (TGW) attending Community-Based Organizations (CBOs) clinics in Thailand.MethodsMSM and TGW aged ≥18 and had HIV risks were enrolled and followed for 12 months with visits every 3 months. Behavioral risks and Sexually Transmitted Infection testing were assessed at every visits. Specimens were collected via pharyngeal swab, urine sample, rectal swab, and neovaginal swab for TGW. These specimens were tested for CT using PoC test. The incidence was calculated using survival analysis, and the Cox regression model for multiple failures.ResultsFrom 2019-2021, 1886 participants were enrolled. Of these, 89.7% were MSM; 10.3% were TGW: 20.7% were lost to follow-up. Of the remaining participants, 18.2% had CT at baseline, with 36.4% experiencing repeat infections. The incidence rate of CT was 42.9 infections per 100 person-years. Predictors of CT infections included enrollment year, age 18-24 years, HIV status, pre-exposure prophylaxis and condom use.ConclusionRepeat CT infections were common. CBOs should incorporate POC STI testing into services, and the provision of STI prevention strategies.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352058"},"PeriodicalIF":1.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV prevalence and prevention behaviors among immigrant men who have sex with men in Brazil and Portugal.","authors":"Alvaro Francisco Lopes de Sousa, Caíque Jordan Nunes Ribeiro, Guilherme Reis de Santana Santos, Matheus Vinícius Cardoso Santos, José Flávio Cerqueira Dos Santos Júnior, Emerson Lucas Silva Camargo, Ana Paula Morais Fernandes, Talita Morais Fernandes, Liliane Moretti Carneiro, Isabel Amélia Costa Mendes","doi":"10.1177/09564624251347491","DOIUrl":"https://doi.org/10.1177/09564624251347491","url":null,"abstract":"<p><p>BackgroundThis study aimed to assess HIV prevalence and associated sexual behaviors among immigrant men who have sex with men (MSM) in Brazil and Portugal, recognizing the elevated vulnerability of this population due to sociocultural and structural barriers.MethodsA cross-sectional online survey was conducted between January 2020 and May 2021 with 2033 immigrant MSM. Participants were recruited using snowball sampling through dating applications. Data were self-reported and analyzed to identify associations between sexual behaviors and HIV status.ResultsThe overall HIV prevalence was 11.7%. Higher-risk sexual practices were frequent, including receptive anal intercourse and having multiple sexual partners. Conversely, low adoption of preventive behaviors such as sexual abstinence and non-penetrative sex was observed. Condomless sex was commonly justified by trust in partners or recent negative HIV test results. Factors independently associated with unprotected sex included being versatile or receptive in anal sex and not disclosing HIV status on dating apps. Gaps in HIV prevention knowledge and engagement were also identified.ConclusionsImmigrant MSM in Brazil and Portugal experience a high burden of HIV and engage in behaviors that increase their risk of infection. Cultural and structural barriers-such as language difficulties, limited healthcare access, and stigma-contribute to inadequate prevention practices. These findings highlight the urgent need for targeted, culturally competent public health interventions to expand access to HIV prevention strategies and reduce transmission risk in this underserved population.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251347491"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term efficacy and safety of fixed-dose dolutegravir-lamivudine in people with HIV: A retrospective study from India.","authors":"Vinay Kulkarni, Ritu Parchure, Shridevi Gundu, Trupti Darak, Kailas Kurkute, Ketan Kulkarni","doi":"10.1177/09564624251352064","DOIUrl":"10.1177/09564624251352064","url":null,"abstract":"<p><p>BackgroundHIV continues to be a significant health concern across the world. Combination antiretroviral therapy (cART) comprising of three-drug regimens has improved clinical outcome but involves long-term toxicity concerns. Hence, to reduce drug exposure, interest in two-drug regimens has increased. This study evaluates the real-world efficacy and safety of a two-drug regimen that is a fixed-dose combination (FDC) of Dolutegravir 50 mg and Lamivudine 300 mg tablets in people living with HIV (PLHIV) in India.MethodsThe retrospective data included PLHIV aged ≥18 years, virally suppressed at baseline, and switched to DTG/3TC between November 2021 and April 2022. Patients were followed for 96 weeks, with routine clinical and laboratory assessments. Virological failure was defined as viral loads >1000 copies/mL, while safety assessments tracked adverse events (AEs), weight gain, and metabolic parameters.ResultsAmong 218 patients (mean age 48.08 ± 10.58 yrs), 97.8% achieved virological suppression at 96 weeks with sustained virological suppression at key time points (24, 48, 72, and 96 weeks). CD4 counts improved significantly (<i>p</i> = .002), specifically in females. Body weight increased moderately, with 16.28% experiencing ≥10% weight gain by 96 weeks. Minor statistically significant variations in cholesterol, triglycerides, and creatinine levels were observed. Nine patients discontinued DTG/3TC due to AEs, primarily weight gain and gastrointestinal issues.ConclusionThe study demonstrates that the DTG/3TC FDC is an effective, safe, and well-tolerated regimen for maintaining virological suppression in real-world settings, supporting its viable use as a switching strategy in reducing drug exposure and managing long-term toxicity.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352064"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of tenofovir alafenamide- or tenofovir disoproxil fumarate-containing regimens in adults with treatment-naïve HIV-hepatitis B co-infection.","authors":"Fehmi Tabak, Dilek Yıldız Sevgi, Esra Zerdali, Ahmet Furkan Kurt, Hayat Kumbasar Karaosmanoğlu, Meliha Meriç Koç, Alper Gunduz, Ahsen Öncül, İnci Yilmaz Nakir, Esra Canpolat Ünlü, Ozlem Altuntaş Aydın, Bilgul Mete","doi":"10.1177/09564624251352345","DOIUrl":"https://doi.org/10.1177/09564624251352345","url":null,"abstract":"<p><p>BackgroundHepatitis B (HBV) infection affects 4%-14% of people with HIV infection in Turkey. Tenofovir alafenamide (TAF) is highly effective in treatment of HIV infection. While it is active against HBV, data on the use in HIV-HBV co-infection are limited.Patients and MethodsWe analyzed the efficacy of tenofovir disoproxil fumarate (TDF)- and TAF-containing regimens in patients with HIV-HBV co-infection from six centers in Istanbul, Turkey. The results of the cohort of 36 months were presented.Results259 patients were enrolled: 146 and 113 were receiving TAF- and TDF-containing regimens respectively. Baseline characteristics were comparable except TAF-containing group was older; had higher CD4 cell count and lower rate of CD4 count ≤200 cells/μL. Baseline HIV-RNA were 8.2 log copies/mL and 6.8 log in TAF- and TDF-containing groups, respectively (<i>p</i> = .059) and HBV-DNA levels were 8.1 log IU/mL in both groups. Thirty-eight and 39% of the patients were HBeAg-positive. After 36 months, undetectable HBV-DNA was noted in 88% and 87%, and undetectable HIV-RNA in 85% and in 83% of TAF and TDF-containing groups, respectively. The increase in mean CD4 cell was significant in both groups: Δ = 311 cells/μL in TAF- and Δ = 393 cells/μL in TDF-containing groups. Rates of HBeAg loss (63% vs 57%), HBeAg seroconversion (35% vs 29%), HBsAg loss (29% vs 27%), and HBsAg seroconversion (23% vs 16%) were comparable at 36 months of therapy.ConclusionThis real-life study showed that both TAF- and TDF-containing regimens are effective in co-infected patients. The rates of HBsAg loss seemed higher than those in HBV-monoinfected patients.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352345"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring mpox vaccination uptake and tolerability among people living with HIV: A study in an infectious disease unit in Italy.","authors":"Samuele Gaggioli, Giuseppe Formica, Valentina Petrini, Alessandra Russo Krauss, Paola Corsi, Alessandro Di Felice, Costanza Fiorelli, Elisabetta Mantengoli, Costanza Malcontenti, Emanuela Francalanci, Giulia Modi, Michele Trotta, Seble Tekle Kiros, Elena Gazzarri, Nicoletta Zocco, Lorenzo Zammarchi, Alessandro Bartoloni, Filippo Lagi","doi":"10.1177/09564624251349888","DOIUrl":"https://doi.org/10.1177/09564624251349888","url":null,"abstract":"<p><p>BackgroundA live attenuated non-replicating vaccine (MVA-BN) is approved for immunization against mpox. We provide an overview of the uptake and tolerability of mpox vaccination among people living with HIV (PLWH) in a single centre in Italy and draw comparisons to individuals without HIV.MethodsWe retrospectively collected clinical data of people vaccinated with MVA-BN in a tertiary-level hospital in Florence, Italy. Baseline data were collected from pre-vaccination screening questionnaires; adverse events data were collected before the second dose through another dedicated questionnaire.ResultsWe vaccinated 332 subjects. Of them, 36.1% (<i>n</i> = 120) were PLWH, with higher median age, higher rate of previous smallpox vaccination and a higher proportion of transgender individuals compared to people without HIV. As for vaccine tolerability, subcutaneous administration was associated with significantly fewer adverse events than intradermal. There were no significant differences in tolerability between PLWH and individuals without HIV. Among people who did not complete the vaccine cycle, migrant and sex worker populations were disproportionately represented.ConclusionOur experience suggests that mpox vaccination has been accepted and well-tolerated in individuals with and without HIV. More work is needed to conduct immunization campaigns in marginalized populations such as migrants and sex workers.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251349888"},"PeriodicalIF":1.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"British Association for Sexual Health and HIV (BASHH) UK national guideline for the use of doxycycline post-exposure prophylaxis (DoxyPEP) for the prevention of syphilis, 2025.","authors":"John Saunders, Joseph Deering, Claire Dewsnap, Rachel Drayton, John Gilmore, Alison Grant, Dwayne-Wilson Hunt, Manik Kohli, Fiona Lyons, Hamish Mohammed, Phil Samba, Benjamin Weil, John White, Nicholas Medland, Helen Fifer","doi":"10.1177/09564624251352053","DOIUrl":"https://doi.org/10.1177/09564624251352053","url":null,"abstract":"<p><p>This guideline provides evidence-based recommendations for the use of doxycycline post exposure prophylaxis (doxyPEP) for the prevention of syphilis. DoxyPEP should be part of a comprehensive approach to the prevention of STIs, along with condom use, appropriate HIV prevention interventions, vaccination, STI testing, treatment and management, and appropriate risk reduction advice and psychological interventions if indicated.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352053"},"PeriodicalIF":1.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C increases acute myocardial infarction risk in people living with HIV: A systematic review and meta-analysis.","authors":"Thanathip Suenghataiphorn, Narisara Tribhuddharat, Pojsakorn Danpanichkul, Thitiphan Srikulmontri, Narathorn Kulthamrongsri","doi":"10.1177/09564624251348688","DOIUrl":"https://doi.org/10.1177/09564624251348688","url":null,"abstract":"<p><p>BackgroundHepatitis C virus (HCV) coinfection is common among people living with HIV (PLWH) and is associated with adverse outcomes. However, the specific association between HCV coinfection and the risk of acute myocardial infarction (AMI) in PLWH remains unclear. This systematic review and meta-analysis aims to clarify this relationship.MethodWe searched MEDLINE and EMBASE databases from inception to October 2024 for cohort studies comparing the incidence of AMI in PLWH with HCV coinfection versus PLWH without HCV coinfection (HIV mono-infection). We used the generic inverse variance method with a random-effects model to pool risk ratios (RRs) and 95% confidence intervals (CIs). Heterogeneity was assessed using the I² statistic. All statistical analyses were performed using Review Manager 5.4.ResultsSeven cohort studies, encompassing 94,664 participants (mean age 42 years, 83% male), met the inclusion criteria. HCV coinfection was associated with a significantly increased risk of AMI in PLWH (pooled RR = 1.25, 95% CI: 1.09, 1.44; I² = 18%; <i>p</i> < .001) compared to HIV mono-infection. A subgroup analysis restricted to type 1 AMI was not statistically significant (pooled RR = 1.03, 95% CI: 0.84, 1.26; <i>p</i> = .78).ConclusionsHCV coinfection is associated with a significantly increased risk of AMI in PLWH. Further research is needed to determine the pathophysiology of this relationship.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251348688"},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, symptomology, and correlates of curable sexually transmitted infections among pregnant women in Eastern Cape, South Africa.","authors":"Natalie G Shaetonhodi, Alex de Voux, Chibuzor M Babalola, Dvora Joseph Davey, Mandisa M Mdingi, Ranjana M S Gigi, Remco P H Peters, Freedom Mukomana, Jeffrey D Klausner, Andrew Medina-Marino","doi":"10.1177/09564624251347484","DOIUrl":"https://doi.org/10.1177/09564624251347484","url":null,"abstract":"<p><p>BackgroundCurable sexually transmitted infections (STIs) contribute to adverse maternal and neonatal outcomes. Syndromic management is standard care in South Africa. We evaluated prevalence, symptomology, and correlates of curable STIs, among pregnant women in Eastern Cape, South Africa.MethodsWe conducted a cross-sectional analysis using baseline data from a randomized controlled trial of pregnant women attending their first antenatal care visit at public clinics in Buffalo City Municipality (2021-2024). Participants were tested for <i>Chlamydia (C.) trachomatis</i>, <i>Neisseria (N.) gonorrhoeae</i>, <i>Trichomonas (T.) vaginalis</i> using GeneXpert point-of-care tests and for syphilis using Alere Determine TP rapid test. Symptoms were self-reported and clinically-observed. Adjusted prevalence ratios were estimated using Poisson regression models with robust standard errors.ResultsAmong 1491 participants (median age: 28 years (IQR: 24-33); gestational age: 13 weeks (IQR: 8-18); HIV prevalence: 30%), STI prevalence was 27.6% (95% CI: 25.3-29.9): <i>C. trachomatis</i> 14.7%, <i>N. gonorrhea</i> 5%, <i>T. vaginalis</i> 10.2%, syphilis 3.4%. Women with HIV had higher STI prevalence (32.8% vs 25.3%, <i>p</i> = .003), particularly for <i>T. vaginalis</i> (17% vs 7.3%, <i>p</i> < .001); 20.1% of women with C<i>. trachomatis</i>, <i>N. gonorrhea</i>, and/or <i>T. vaginalis</i> were symptomatic, and 63% of symptomatic women tested STI-negative. Younger age, lower education, multiple sex partners and unknown HIV-serostatus of partners were associated with increased STI prevalence.ConclusionWe observed a high prevalence of STIs, particularly among women with HIV, with many asymptomatic cases; emphasizing the need for integrated point-of-care testing to ensure timely treatment, reduce antibiotic overuse, and improve maternal and neonatal outcomes.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251347484"},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with sexually transmitted reinfections, number of sexual partners and condom use among previously infected young people.","authors":"Isobel Landray, James R Carpenter, Sima Berendes, Melissa J Palmer, Caroline Free","doi":"10.1177/09564624251348693","DOIUrl":"https://doi.org/10.1177/09564624251348693","url":null,"abstract":"<p><p>BackgroundSexually transmitted infections (STIs) are prevalent in young people. Digital interventions promoting safer sexual behaviours are low-cost and scalable. We use data from a randomised controlled trial of one such potential intervention (safetxt) to investigate factors associated with STI reinfection and risky sexual behaviours.MethodsWe use data from 6248 young people with STIs recruited from 92 UK sexual health clinics. Multivariable logistic regression models were developed with the outcomes: reinfection, condom use at last sex and number of sexual partners (≤1 or >1) at 1 year. A pre-specified variable selection process assessed effects of sociodemographic and sexual behaviour factors measured at trial baseline.ResultsFactors associated with reinfection included sexuality, ethnicity, baseline diagnosis of gonorrhoea and chlamydia, index of multiple deprivation, whether the participant and/or the last new partner tested before sex. Risk factors for condom use at last sex and number of sexual partners included sexuality and education level. The multivariable models had good calibration but poor discrimination.ConclusionsIn this large sample with good representation across social and ethnic groups, we identified patient characteristics associated with higher risk of reinfection. Improved understanding of factors associated with reinfections and higher-risk sexual behaviours can aid development of interventions.Trial RegistrationISRCTN64390461.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251348693"},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}