International Journal of STD & AIDS最新文献

{"title":"Patterns of sleep problems and associated factors in older people living with HIV: A latent class analysis.","authors":"Aodi Zhang, Wen Cheng, Bolin Yang, Jibiao Chen, Hanlu Yin, Jing Gu, Zhuping Xu, Peng Xu, Xiaojun Meng","doi":"10.1177/09564624251349594","DOIUrl":"https://doi.org/10.1177/09564624251349594","url":null,"abstract":"<p><p>BackgroundTo identify sleep subtypes and associated factors in older people living with HIV (PLWH).MethodsA cross-sectional study was conducted to recruit older PLWH in Wuxi, China. Sleep quality was assessed using the Pittsburgh Sleep Quality Index. Latent class analysis was employed to examine sleep patterns, and logistic regression was performed to analyze associated factors.ResultsIn total, 830 participants were recruited with a median age of 60.9 years (IQR 55.4-67.9), of whom 79.0% were male, and 25.4% had sleep disorders. Three sleep patterns were identified: optimal sleep (48.3%), poor sleep (39.9%), and bad sleep (11.8%). Compared to the optimal sleep group, housing area (OR = 0.67, 95% CI: 0.50-0.91), social media app usage (OR = 0.57, 95% CI: 0.37-0.87), and years living with HIV (OR = 1.49, 95% CI: 1.05-2.10) were significantly associated with poor sleep. In contrast, age (OR = 1.89, 95% CI: 1.12-3.20), sex (OR = 1.94, 95% CI: 1.15-3.27), exercise frequency (OR = 1.64, 95% CI: 1.02-2.63), polypharmacy (OR = 0.27, 95% CI: 0.14-0.52), and years living with HIV (OR = 1.85, 95% CI: 1.11-3.07) were significantly associated with bad sleep.ConclusionsSignificant heterogeneities were observed across different sleep patterns among older PLWH. Potential associated factors should be considered when developing targeted strategies to improve sleep quality in this population.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251349594"},"PeriodicalIF":1.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the hidden epidemic: A scoping review of sexually transmitted diseases in Southeast Asia.","authors":"Nazri Che Dom, Rahmat Dapari, Mohamad Adzrin Harith Mohamad Syahriman, Adam Adha Mohd Sukri, Nur Leiza Azwa Kamarudin, Nur Shuhada Aqilah Ahmad Bakhtiar, Nur Syabila Alya Khairi, Nopadol Precha, Wan Shahriman Yushdie Wan Yusoff","doi":"10.1177/09564624251349598","DOIUrl":"https://doi.org/10.1177/09564624251349598","url":null,"abstract":"<p><p><b>Background:</b> Sexually transmitted diseases (STDs) pose a significant global health challenge, with Southeast Asia bearing a disproportionately high burden due to socio-demographic vulnerabilities, disparities in healthcare access, and prevailing cultural stigmas. Despite growing research interest in the region, a comprehensive synthesis of disease burden, risk factors, and intervention strategies remains limited.<b>Objectives:</b> This study aimed to systematically review research trends, study populations, and pathogen distributions of STDs in Southeast Asia to identify evidence gaps and inform future policy and intervention strategies.<b>Methods:</b> A systematic literature search was conducted using Scopus, Web of Science, and PubMed databases in accordance with PRISMA guidelines. Eligible studies were those focusing on STDs in Southeast Asia and included high-risk populations such as men who have sex with men (MSM), sex workers, youth, heterosexual men and women, transgender individuals, and people living with HIV (PLHIV). The review encompassed key STDs including HIV/AIDS, syphilis, gonorrhea, chlamydia, HPV, trichomoniasis, and hepatitis B & C.<b>Results:</b> From 2,867 records, 58 studies met the inclusion criteria. HIV/AIDS was the most frequently studied STD (80%), while bacterial STDs and transgender populations were significantly underrepresented. Most studies employed cross-sectional designs (60%), with few longitudinal or interventional studies. Geographically, research was concentrated in Malaysia, Thailand, and Singapore, with limited representation from Cambodia, Vietnam, and Indonesia.<b>Discussion:</b> The findings underscore substantial research gaps, particularly in bacterial STDs, studies involving heterosexual and transgender populations, and the application of intervention-based designs. Inconsistencies in reporting standards and population definitions further limit the comparability of findings across studies.<b>Conclusion:</b> This review highlights the need for more inclusive and methodologically diverse research on STDs in Southeast Asia. Future efforts should prioritize standardized data collection frameworks, improved surveillance systems, and greater emphasis on intervention studies to strengthen evidence-based public health responses in the region.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251349598"},"PeriodicalIF":1.4,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary syphilis presenting with elevated CA19-9: A report of two cases.","authors":"Toshiya Nakashima, Hiroshi Ito, Koki Kikuchi","doi":"10.1177/09564624251348680","DOIUrl":"https://doi.org/10.1177/09564624251348680","url":null,"abstract":"<p><p>Syphilis is known for its diverse and often deceptive clinical manifestations, yet its potential to elevate tumor markers such as carbohydrate antigen 19-9 (CA19-9) remains underrecognized. We report two cases of secondary syphilis, each presenting with markedly elevated CA19-9 levels in the absence of malignancy. Both patients exhibited cholestatic liver enzyme elevations, and neither had structural abnormalities in the pancreaticobiliary system. In both cases, CA19-9 levels normalized following appropriate antibiotic treatment for syphilis. These cases suggest that systemic inflammation, hepatocellular injury with regenerative changes, and epithelial damage associated with syphilitic hepatitis may contribute to transient CA19-9 elevation.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251348680"},"PeriodicalIF":1.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vespasiano Gonzaga, founder of Sabbioneta, and his Renaissance disease.","authors":"Gianluca Nazzaro","doi":"10.1177/09564624251347419","DOIUrl":"https://doi.org/10.1177/09564624251347419","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251347419"},"PeriodicalIF":1.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmission of gonorrhea from the oral cavity to the rectal tract: A systematic review.","authors":"Yuri Garcia Dutra Souza, Yan Rocha Neves, Valéria de Oliveira, Luiz Eduardo de Almeida, Mabel Miluska Suca Salas","doi":"10.1177/09564624251347457","DOIUrl":"https://doi.org/10.1177/09564624251347457","url":null,"abstract":"<p><p>BackgroundThe antimicrobial resistance of Neisseria gonorrhoeae and the high prevalence of asymptomatic extragenital infections are a worldwide concern. This research investigated whether gonorrhea can be transmitted from the oral cavity to the anorectal tract among men who have sex with men.<b>Purpose</b>The aim of this research is to find plausible relationships regarding the probability of gonococcal transmission from the oral cavity to the anorectal tract among MSM.<b>Research Design</b>A research question was defined using the P.I.C.O. strategy (population, intervention or exposure, comparison and outcome), where the target population is MSM, the intervention is exposure to contaminated oral cavity/saliva, the control is the absence of exposure, and the outcome is the acquisition of GC. The eligibility criteria included observational studies involving men who have sex with men, regardless of sexual orientation, aged 16 or older, screened for oropharyngeal and rectal gonorrhea, and examining the role of oral fluids in transmission. Studies involving partners previously diagnosed with urogenital gonorrhea or reporting consistent condom use during receptive penoanal sex were excluded to avoid urethral-to-anorectal transmission bias.<b>Study Sample</b>The databases employed were PubMed, Scopus, Web of Science, EBSCO, SciELO, and the Virtual Health Library (VHL). A total of 383 studies were identified, however, only 6 were included.<b>Data Collection and/or Analysis</b>According to the Newcastle-Ottawa Scale (NOS), two studies were \"very good,\" two \"good,\" and two \"satisfactory\". Most studies described a complete methodology according to Strengthening the Reporting of Observational studies in Epidemiology (STROBE).<b>Results</b>Differences in diagnostic methods, methodologies, and variables limited the findings. While the results do not confirm transmission from the oral cavity to the anorectal tract, they suggest its possibility. Further research is needed to better understand this transmission route.<b>Conclusions</b>Transmissibility of gonorrhea from oropharyngeal via to the anorectal tract cannot be totally establish. However, evidence suggested the existence of this gonorrhea transmission. The fact that men with rectal gonorrhea continue to appear, even in contexts of condom use or the absence of receptive penoanal sex, brings the importance of cases monitoring and the establishment of preventive strategies.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251347457"},"PeriodicalIF":1.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention and management strategies of anal squamous cell carcinoma among men who have sex with men living with HIV.","authors":"Zhi Wang, Xudong Zhao, Wenchao Du, Xiaoliang Zhang, Xingxing Li, Linquan Wang","doi":"10.1177/09564624251333035","DOIUrl":"10.1177/09564624251333035","url":null,"abstract":"<p><p>The incidence of anal squamous cell carcinoma (SCCA) has been rapidly increasing in recent years. The burden of the disease is expected to increase in the forthcoming years. Men who have sex with men living with HIV (MSMLWH) have a higher incidence of SCCA than the general population. The progression of SCCA usually develops from high risk human papillomavirus (HR-HPV) infection to high grade squamous intra-epithelial lesions (HSIL). HPV infection is highly prevalent in MSMLWH and is considered the most important risk factor for SCCA in MSMLWH. Although the prevalence worldwide is largely similar, the distribution of high-risk HPV genotypes varies. Education on sexuality and lifestyle, use of condoms, fixed sexual partner, effective antiretroviral therapy (ART), smoking cessation, and preventive male circumcision could reduce HPV infection in MSMLWH. Screening and treatment of HSIL have been widely applied to prevent SCCA, but divergence still exists in many studies. When treating HSIL, patients of different ages and risk factors need more consideration to develop standardized management strategies, especially for MSMLWH. Very few studies have examined the treatment of SCCA with MSMLWH. ART has dramatically changed the treatment of SCCA in MSMLWH. The safety and outcome of treatment are still primary concerns for MSMLWH. More studies in this field are necessary to develop treatment strategies for MSMLWH.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"533-541"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing non-sterile glove use in a sexual health and HIV department: A quality improvement project to address clinical practices.","authors":"Laurie Smith, Amanda Clarke, Gillian Dean","doi":"10.1177/09564624251326696","DOIUrl":"10.1177/09564624251326696","url":null,"abstract":"<p><p>BackgroundClimate change is a huge public health threat, necessitating reductions in carbon emissions, particularly from single-use plastics like non-sterile gloves (NSG). This quality improvement project aims to explore whether use of targeted educational material changes staff attitudes towards NSG use in clinical practice within a Sexual Health and HIV department.MethodsA pre-intervention survey was circulated to all clinicians. Subsequently, various methods encouraged appropriate NSG use including video guidance of performing venepuncture without gloves in line with Trust policy, educational presentations, and patient-facing posters for waiting rooms. NSG procurement data were obtained, and a post-intervention survey evaluated whether NSG use had changed following the interventions.ResultsSixty-three percent of staff believed they had reduced their personal glove use in the past year. Many staff believed the best way to reduce inappropriate glove use was through education as well as empowering patients through posters. Glove procurement data comparing 2023/2024 to pre-COVID 2019/2020 showed a 45.2% decrease in NSG orders from 173,110 to 94,800 per year.ConclusionsStaff education is successful in reducing inappropriate NSG use, with patient posters and targeted staff presentations the most effective measures to drive behaviour change and therefore reduce NSG use.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"583-586"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A male patient with <i>Chlamydia</i> peritonitis: Case report.","authors":"Aude Van Oosterwyck, Eric Van Wijngaerden, Philip Roelandt","doi":"10.1177/09564624251329633","DOIUrl":"10.1177/09564624251329633","url":null,"abstract":"<p><p>Pelvic inflammatory disease (PID) is a well-known entity in women. However, on rare occasions, men can present with peritonitis caused by <i>Chlamydia trachomatis</i> as well. It is important to know and recognise this entity in order to avoid unnecessary investigations and commence prompt treatment.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"595-596"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of multi-level factors and partner characteristics on antiretroviral therapy adherence and access to HIV care during the COVID-19 pandemic.","authors":"Paige Neuenschwander, Andrea Norcini Pala, Fredrick L Altice, Robert H Remien, Gaukhar Mergenova, Elena Rozental, Valeriy Gulyayev, Alissa Davis","doi":"10.1177/09564624251329626","DOIUrl":"10.1177/09564624251329626","url":null,"abstract":"<p><p>BackgroundAdherence to antiretroviral therapy (ART) remains a challenge for many people with HIV and was exacerbated during the COVID-19 pandemic. This paper examines factors associated with ART adherence among people with HIV who inject drugs (PWHWID) in Almaty, Kazakhstan during the COVID-19 pandemic.MethodsA cross-sectional survey was conducted from October 2020 to August 2022 with 66 PWHWID and their treatment support partners (<i>n</i> = 66) to assess associations between ART adherence and sociodemographic, COVID-19 related, social support, and other factors. Multilevel generalized linear mixed models were used to examine factors associated with optimal (≥90%) and standard (≥80%) adherence levels.ResultsWe found low medication adherence rates: only 55.8% took ≥80% of their doses, and just 14.7% took ≥90%. People were more likely to take their medication consistently if they had a partner with HIV, experienced less household conflict during COVID-19, or met with addiction professionals. Poor mental health and negative emotional impacts from COVID-19 were associated with low adherence.ConclusionThese findings suggest that HIV treatment programs should consider the importance of patients' relationship factors, mental health, and home environment impacts during public health crises.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"568-576"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Are new lipid lowering agents a good option for achieving lipid goals in people living with HIV? A case report\".","authors":"Raffaele Ferri, Katia Falasca, Jacopo Vecchiet, Claudio Ucciferri","doi":"10.1177/09564624251327237","DOIUrl":"10.1177/09564624251327237","url":null,"abstract":"<p><p>The dyslipidemia in people living with HIV differs from the general population because combination antiretroviral therapy may not only induce dyslipidemia but also interact with lipid-lowering agents.Monoclonal antibodies that target proprotein convertase subtilisin/kexin type 9 (PCSK9) have recently been demonstrated to dramatically reduce LDL-C level (>60%) in the majority of cases, and another interesting new option is inclisiran, a first-in-class, cholesterol-lowering small interfering RNA (siRNA) targeting PCSK9 mRNA and conjugated to triantennary N-acetylgalactosamine carbohydrates (GalNAc).We present the clinical case of a 62-year-old man living with HIV and dyslipidemia in whom new hypolipidemic drugs were fundamental in achieving adequate LDL values to prevent cardiovascular events.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"591-594"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}