International Journal of STD & AIDS最新文献_第5页

Expanding access to STI care with free of charge, convenient services in sexual health walk-in clinics. 在无预约性健康诊所提供免费、便捷的服务，扩大获得性传播感染治疗的机会。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-03-11 DOI: 10.1177/09564624251325310

Vivian I Avelino-Silva, Alexander Goncalvez, Whitney Engeran, Laura Boudreau, Michael Weinstein, Adele Schwartz Benzaken

{"title":"Expanding access to STI care with free of charge, convenient services in sexual health walk-in clinics.","authors":"Vivian I Avelino-Silva, Alexander Goncalvez, Whitney Engeran, Laura Boudreau, Michael Weinstein, Adele Schwartz Benzaken","doi":"10.1177/09564624251325310","DOIUrl":"https://doi.org/10.1177/09564624251325310","url":null,"abstract":"Background: Sexually transmitted infections (STIs) are a long-standing public health issue with increasing incidence in recent years even though most STIs can be effectively treated or even cured with inexpensive medications.Purpose/Design: In this manuscript, we discuss factors that contribute with this concerning scenario, including modifications in the model of STI care in the United States; barriers for diagnosis and treatment; and scarcity of targeted STI prevention messages. We then describe the approach adopted by AIDS Healthcare Foundation to mitigate STI trends, with a focus on sexual health Wellness Centers.Results: The main characteristics of this program include free and convenient services with large volume capacity, sex-positive culture, advertisement of available resources, and accessibility to key populations at higher risk for STI acquisition.Conclusions: This experience could be adapted and expanded to other settings, supporting the public health mission of controlling the spread and detrimental outcomes of STIs.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251325310"},"PeriodicalIF":1.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic drug monitoring of tenofovir disoproxil and emtricitabine in oral HIV pre-exposure prophylaxis (PrEP) users who have undergone gastrointestinal surgery. 对接受过胃肠道手术的口服艾滋病暴露前预防 (PrEP) 服用者进行替诺福韦酯和恩曲他滨的治疗药物监测。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-03-01 Epub Date: 2024-11-05 DOI: 10.1177/09564624241298983

Muhammad Azam Ismail, Victoria Tittle, Rachael Jones, Hannah Loftus, Nicolo Girometti, Olamide Dosekun, Katrina Stegmann, Erica Pool, Shema Tariq, Anna Nakamura, Stephanie Tyler, Harry Coleman, Yee Suh Teh, Marta Boffito

{"title":"Therapeutic drug monitoring of tenofovir disoproxil and emtricitabine in oral HIV pre-exposure prophylaxis (PrEP) users who have undergone gastrointestinal surgery.","authors":"Muhammad Azam Ismail, Victoria Tittle, Rachael Jones, Hannah Loftus, Nicolo Girometti, Olamide Dosekun, Katrina Stegmann, Erica Pool, Shema Tariq, Anna Nakamura, Stephanie Tyler, Harry Coleman, Yee Suh Teh, Marta Boffito","doi":"10.1177/09564624241298983","DOIUrl":"10.1177/09564624241298983","url":null,"abstract":"Objectives: Oral HIV pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV, but its efficacy depends on adequate absorption of drug, which may decrease following gastrointestinal surgery.Methods: Clinicians across eight Genito-urinary Medicine clinics in the United Kingdom submitted data on PrEP users with history of gastrointestinal surgery who were referred to a national complex PrEP multi-disciplinary team between June 2021 and April 2023. Anonymised data were submitted on demographics, surgical history, PrEP regimen, and results of therapeutic drug monitoring (TDM) and HIV screening tests. Descriptive analyses were performed in SPSS version 29.Results: Nine cases described cis-gender men-who-have-sex-with-men (MSM) with median age of 47.4 years (IQR = 43 - 56.5) taking tenofovir disoproxil (TDF)/emtricitabine (FTC) daily (n = 8) or event-based (n = 1) as PrEP. Median time between PrEP initiation and TDM was 53 days (IQR = 8.5-1705). The mean (±SD) trough concentration of tenofovir (TFV) and FTC were 90.2 ± 27.7 ng/mL and 76.0 ± 45.9 ng/mL, respectively. All patients had a negative HIV test at follow-up.Conclusions: Plasma trough concentrations of TFV observed in our cohort taking TDF/FTC were above the expected concentrations associated with PrEP efficacy as previously described in the literature, suggesting that PrEP can be safely given in this population, with TDM used for reassurance.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"250-254"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acceptability and feasibility of HIV pre-exposure prophylaxis (PrEP) in Southeast Asia: A scoping review. 艾滋病毒暴露前预防（PrEP）在东南亚的可接受性和可行性：范围审查。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-03-01 Epub Date: 2024-12-11 DOI: 10.1177/09564624241306158

Justitia Roma Espera, Chaia Alyssa Reyes, Erla Grace Sarmiento, Czarina Mae Sitchon, Roueline Zantua, Rogie Royce Carandang

{"title":"Acceptability and feasibility of HIV pre-exposure prophylaxis (PrEP) in Southeast Asia: A scoping review.","authors":"Justitia Roma Espera, Chaia Alyssa Reyes, Erla Grace Sarmiento, Czarina Mae Sitchon, Roueline Zantua, Rogie Royce Carandang","doi":"10.1177/09564624241306158","DOIUrl":"10.1177/09564624241306158","url":null,"abstract":"Background: The availability of HIV pre-exposure prophylaxis (PrEP) in Southeast Asia remains limited compared to regions like Western Europe or North America. Additionally, little is known about how key populations in Southeast Asia perceive the use of PrEP as a prevention tool for HIV. This scoping review aims to provide an overview of the literature on the acceptability and feasibility of HIV PrEP programs in Southeast Asia.Methods: We conducted a systematic search using nine electronic databases, gray literature searches, and hand searches of references in included full-text articles. Following PRISMA guidelines for scoping reviews, we focused on original research articles published in English from July 2012 to December 2022. A narrative synthesis was used to summarize the findings.Results: We identified 8,871 articles through the database search, removed 1,094 duplicates, and excluded 7,745 articles after title and abstract screening. Over 28 articles met the inclusion criteria. The use of PrEP was found to be highly acceptable, with participants showing a willingness to use and pay for it, moderate usage rates, convenience, and preference over other prevention methods. It was also considered highly feasible due to its effectiveness and successful program implementation. However, barriers included risk compensation, concerns about side effects, the burden of daily pill administration, and, most commonly noted in studies, cost.Conclusion: HIV PrEP has been shown to be both acceptable and feasible. The necessity for direct efforts to expand PrEP access in Southeast Asia and address barriers to its uptake and adherence underscores the importance of ongoing monitoring and implementation.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"260-274"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermoscopy of syphilitic chancre: Report of five cases. 梅毒下疳皮肤镜检查附5例报告。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI: 10.1177/09564624241310325

Payal Chauhan, Ria Sharma, Manju Daroach, Rashmi Jindal, Dilip Meena

引用次数: 0

A case of acquired syphilis in an infant through mouth-to-mouth transmission of prechewed food. 通过咀嚼过的食物口对口传播的婴儿获得性梅毒病例。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-03-01 Epub Date: 2025-01-08 DOI: 10.1177/09564624241312950

Sen Feng, Qing Zhu, Mingyuan Ren, Guoying Miao, Guoqiang Zhang

{"title":"A case of acquired syphilis in an infant through mouth-to-mouth transmission of prechewed food.","authors":"Sen Feng, Qing Zhu, Mingyuan Ren, Guoying Miao, Guoqiang Zhang","doi":"10.1177/09564624241312950","DOIUrl":"10.1177/09564624241312950","url":null,"abstract":"Background: Patients with syphilis are the only source of infection, which can be transmitted through sexual contact and mother-to-child and blood transmission, and rarely through contaminants. The clinical manifestations of syphilis are complex and variable, and can be easily misdiagnosed. This article reports a case of syphilis in a child with \"psoriasis\"-like lesions who was fed pre-chewed food.Case presentation: An 18-month-old girl presented with mung bean to peanut-sized erythema and papules scattered on both lower limbs and perianal area; some of the erythema was covered with scales, with clear boundaries and no fusion. The case was misdiagnosed as \"psoriasis\" in the local hospital until the child and her mother tested positive for syphilis in the outpatient clinic of our hospital. The girl's mother had a habit of chewing food in her mouth before feeding it to her child.Conclusions: Consumption of food chewed by a person with syphilis can lead to infection, and attention should be paid to the possible ways and means of being infected.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"334-336"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Awareness, knowledge and readiness of clinicians to deliver 4CMenB vaccines for Neisseria gonorrhoeae prevention. 临床医生为预防淋病奈瑟菌提供4CMenB疫苗的认识、知识和准备情况。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-03-01 Epub Date: 2024-12-06 DOI: 10.1177/09564624241306157

Lucy Rabuszko, Sarah Stuart-George, Deborah Williams, Daniel Richardson

引用次数: 0

Persistence of HPV in cervical smears of vaccinated WLWH support for combined molecular testing and cytology screening. HPV在接种WLWH子宫颈涂片中的持续存在支持联合分子检测和细胞学筛查。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI: 10.1177/09564624241310947

Milena Siqueira Pereira, Silvia Maria Baeta Cavalcanti, Charbell Miguel Haddad Kury, Willker Menezes da Rocha, Rafael Brandão Varella

{"title":"Persistence of HPV in cervical smears of vaccinated WLWH support for combined molecular testing and cytology screening.","authors":"Milena Siqueira Pereira, Silvia Maria Baeta Cavalcanti, Charbell Miguel Haddad Kury, Willker Menezes da Rocha, Rafael Brandão Varella","doi":"10.1177/09564624241310947","DOIUrl":"10.1177/09564624241310947","url":null,"abstract":"Background: Human papillomavirus (HPV) infection profoundly affects women living with HIV (WLWH). This infection leads to cervical cancer (CC) and increased mortality.Methods: This study monitored HPV infection in WLWH in Rio de Janeiro, Brazil, before (T1) and after (T2) 4 years of vaccination. HPV genotyping and the presence of intraepithelial lesions were investigated at both time points.Results: Among the 156 WLWH who received the quadrivalent HPV vaccine (4vHPV) at T1, 30 (19.2%) were initially found to have HPV DNA. After vaccination, only three (7%) of those who were HPV-negative at T1 tested positive for HPV. Most women who tested positive for HPV DNA at T1 had normal Pap smear results. However, this cohort also demonstrated a significant increase in cases of atypical squamous cells of uncertain significance and cervical intraepithelial neoplasia in PCR-negative HPV DNA samples at T2 (p < .01). Conversely, women who initially tested negative for HPV DNA continued to exhibit normal Pap smear results in 2018 (p < .01).Conclusions: This study highlights the persistence of HPV in WLWH despite vaccination and underscores the importance of continued molecular and cytologic screening. The findings enhance our understanding of vaccine effectiveness in this population and emphasize the need for tailored preventive strategies.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"304-308"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Admission diagnoses and outcomes among hospitalized people living with HIV during pre-COVID-19, COVID-19 and post-COVID-19 pandemic periods. 在COVID-19前、COVID-19和COVID-19大流行后住院的艾滋病毒感染者的入院诊断和结果

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-03-01 Epub Date: 2024-12-04 DOI: 10.1177/09564624241304849

Pattarapoom Panutat, Thana Khawcharoenporn

{"title":"Admission diagnoses and outcomes among hospitalized people living with HIV during pre-COVID-19, COVID-19 and post-COVID-19 pandemic periods.","authors":"Pattarapoom Panutat, Thana Khawcharoenporn","doi":"10.1177/09564624241304849","DOIUrl":"10.1177/09564624241304849","url":null,"abstract":"Background: Data on the impact of coronavirus disease 2019 (COVID-19) on hospitalization and outcomes among people living with HIV (PLHIV) are limited.Methods: A retrospective cohort study was conducted among PLHIV hospitalized during the pre-COVID-19, COVID-19, and post-COVID-19 periods.Results: Of the 310 PLHIV included, 117, 125 and 68 were admitted during the three periods, respectively and 115 (37%) were newly diagnosed with HIV. Median CD4 cell counts and proportions of those with antiretroviral therapy (ART) adherence rates ≥95% at admission were different between the three periods [(206, 97 and 138 cells/mm3 (p = .02) and 97%, 89% and 100% (p = .06), respectively]. Of the 310 PLHIV, admission diagnoses were non-AIDS-related (62%) and AIDS-related (38%). Most of the non-AIDS-related diagnoses were infections other than opportunistic infections (OIs) (40%) while OIs were the most common for AIDS-related diagnoses (88%). The types of admission diagnoses were comparable between the three periods. Hospital mortality rates were 10%, 13% and 16% during pre-COVID-19, COVID-19 and post-COVID-19 periods, respectively (p = .80). By multivariable analysis, intensive care unit admission, underlying malignancy, monthly income less than $USD 400, and admission CD4 less than 50 cells/mm3 were independently associated with hospital mortality.Conclusions: Although admission during COVID-19 pandemic period was not associated with increased mortality, we observed the impact of the pandemic on the lower CD4 cell count and ART adherence at admission among hospitalized PLHIV. Interventions to improve early care engagement, ART adherence, and close monitoring for those with identified mortality risks are needed for better HIV care, especially during pandemics.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"231-240"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HI Acquired palmoplantar keratoderma in an immunocompromised patient: A case report. 免疫功能低下患者获得性掌足底角化病1例报告。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-03-01 Epub Date: 2024-12-08 DOI: 10.1177/09564624241307732

Daniel Z Villarreal-Martínez, Mayra A Reyes-Soto, Leslie M Garza-García, Jair A Valdez-Zertuche, Daniela López-Quintero, Sonia Chavez-Alvarez, Jorge Ocampo-Candiani, Alejandra Villarreal-Martínez

引用次数: 0

The challenges in lymphogranuloma venereum diagnosis whether NAAT is negative, a case series. NAAT是否阴性对性病性淋巴肉芽肿诊断的挑战。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-03-01 Epub Date: 2024-12-10 DOI: 10.1177/09564624241307733

Igor Malec, Robin Vanstokstraeten, Eveline Van Honacker, Pierre Lefesvre, Dunja Wilmes, Kathleen Van Damme, Marco Moretti

{"title":"The challenges in lymphogranuloma venereum diagnosis whether NAAT is negative, a case series.","authors":"Igor Malec, Robin Vanstokstraeten, Eveline Van Honacker, Pierre Lefesvre, Dunja Wilmes, Kathleen Van Damme, Marco Moretti","doi":"10.1177/09564624241307733","DOIUrl":"10.1177/09564624241307733","url":null,"abstract":"Background: Persistent inguinal lymphadenopathy can range from benign to malignant causes. Lymphogranuloma venereum (LGV), a sexually transmitted infection (STI), is a possible cause, particularly in individuals engaged in sexual practices associated with a higher likelihood of transmitting STIs. This case series outlines the diagnostic challenges of LGV.Case presentation: Two male patients, aged 36 and 48, with sexual practices associated with an elevated risk of STI transmission, presented with inguinal lymphadenopathy. Initial investigations, including rectal and genital nucleic acid amplification tests (NAATs) for STIs, were negative. Patient one underwent two fine-needle aspirations, both inconclusive. An excisional biopsy later confirmed LGV through a positive NAAT for Chlamydia trachomatis and consistent pathology. The diagnosis took several years, included three PET scans, and was complicated by a surgical site infection with Staphylococcus aureus. Patient 2, despite negative NAAT results, was empirically treated for LGV based on clinical suspicion, with resolution after doxycycline.Intervention and outcome: Both patients improved significantly with doxycycline. Retrospective serology showed elevated Chlamydia trachomatis IgG titers, supporting this diagnosis.Conclusion: This case series emphasizes the need to consider LGV in patients with persistent lymphadenopathy and sexual practices that may increase the likelihood of STIs.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"283-288"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0