International Journal of STD & AIDS最新文献_第5页

The PrEP cascade in a sample of HIV-negative or unknown status adolescent and young adult transgender women in Peru. 秘鲁 HIV 阴性或状况不明的青少年和年轻成年变性妇女样本中的 PrEP 级联。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-02-01 Epub Date: 2024-11-17 DOI: 10.1177/09564624241272940

Sari L Reisner, Dorothy Apedaile, Alfonso Silva-Santisteban, Leyla Huerta, Rodrigo Aguayo-Romero, Amaya Perez-Brumer

{"title":"The PrEP cascade in a sample of HIV-negative or unknown status adolescent and young adult transgender women in Peru.","authors":"Sari L Reisner, Dorothy Apedaile, Alfonso Silva-Santisteban, Leyla Huerta, Rodrigo Aguayo-Romero, Amaya Perez-Brumer","doi":"10.1177/09564624241272940","DOIUrl":"10.1177/09564624241272940","url":null,"abstract":"Background: Transgender women are a key population in the HIV epidemic globally, including in Peru. This cross-sectional epidemiological study characterized the pre-exposure prophylaxis (PrEP) cascade in adolescent and young adult transgender women in Peru to inform roll-out of early HIV prevention efforts.Methods: Between February-July 2022, a community-recruited sample of HIV-negative or status unknown young transgender women (n = 140) in Peru completed a socio-behavioral survey and biological testing for HIV and bacterial STIs. Logistic regression models estimated the association of sociodemographic, healthcare, and behavioral factors to PrEP indication and willingness.Results: Median age was 22 years (range = 16-24 years); 65.7% reported sex work and 28.6% homelessness. Overall, 45.7% had a PrEP indication based on past 6 months HIV behavioral risk profiles. In a multivariable model, sex work (aRR = 2.27; 95% CI = 1.24-4.17) and homelessness (aRR = 1.27; 95% CI = 1.00-1.60) were associated with PrEP indication. More than one-third (38.6%) had never been HIV tested; 25.3% were tested >1 year ago. Only 34.3% heard of daily oral PrEP, 8.6% reported ever PrEP use, and 5.0% current PrEP use. Nearly half (49.3%) reported willingness to take daily oral PrEP. In a multivariable model, younger age was associated with increased willingness to use PrEP (aRR = 0.92; 95% CI = 0.87-0.98). Highest ranked PrEP preferences were a daily oral pill (35.7%), implant (32.1%), and injection by a provider (10.0%).Conclusions: PrEP indication and willingness were high in this sample, but HIV testing and PrEP uptake were low. Findings highlight opportunities for age-responsive and contextually-relevant interventions to increase HIV prevention among young transgender women in Peru.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"141-150"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An uncommon cause of persistent infection by Trichomonas vaginalis. 阴道毛滴虫持续感染的一个不常见原因。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-02-01 Epub Date: 2024-09-26 DOI: 10.1177/09564624241260756

Jimena Varona, María Jesús Barberá, Josefina López de Munain

引用次数: 0

Successful outcome of performing CO2 laser ablation in a middle-aged female with angiokeratoma of Fordyce. 为一名患有福特斯血管角化瘤的中年女性成功实施二氧化碳激光消融术。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-02-01 Epub Date: 2024-11-09 DOI: 10.1177/09564624241299571

Janice Reema Lewis, Ramesha Bhat M, Archana Bhat, Michelle Serene Fernandes, Jacintha Martis

引用次数: 0

Mycobacterium avium complex (MAC) infection in severely immunocompromised people living with HIV: Findings from a five-year cohort. 免疫力严重低下的艾滋病病毒感染者中的复合分枝杆菌（MAC）感染：一项为期五年的队列研究结果。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-02-01 Epub Date: 2024-11-05 DOI: 10.1177/09564624241297835

María Del Rocío Fernández-Díaz, Naya Faro-Miguez, María Aguilera-Franco, Leopoldo Muñoz-Medina, Andrés Ruiz-Sancho, Javier Rodríguez-Granger, Emilio Guirao-Arrabal

{"title":"Mycobacterium avium complex (MAC) infection in severely immunocompromised people living with HIV: Findings from a five-year cohort.","authors":"María Del Rocío Fernández-Díaz, Naya Faro-Miguez, María Aguilera-Franco, Leopoldo Muñoz-Medina, Andrés Ruiz-Sancho, Javier Rodríguez-Granger, Emilio Guirao-Arrabal","doi":"10.1177/09564624241297835","DOIUrl":"10.1177/09564624241297835","url":null,"abstract":"Background: We sought to clarify the current incidence, risk factors and symptoms of disseminated Mycobacterium avium complex (dMAC) infection in admitted people living with HIV in a hospital in the Southeast of Spain.Methods: 5-years observational, retrospective and single-centre study. Demographic, clinical and analytical variables, along with microbiological, treatment and follow-up were collected.Results: Five cases of dMAC infection in severely immunocompromised people living with HIV people living were found. dMAC was diagnosed in 22.7% of patients under 100 CD4. All patients presented with fever and clinical manifestations of pneumonia, lymphadenopathy, or gastrointestinal symptoms. Despite low CD4 levels and high viral loads in some cases, primary prophylaxis had not been previously administered.Conclusions: Until 2018, U.S. American guidelines recommended antimycobacterial prophylaxis for patients with low CD4 cell counts, a practice not adopted in Europe. Untreated dMAC infection is associated with high morbidity and mortality rates. dMAC infection represents a prevalent disease in severely immunosuppressed people living with HIV. dMAC requires a high index of suspicion in this population, in order to perform mycobacterial cultures from different samples.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"126-131"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association among therapeutic adherence, health literacy, and engagement in care: How to increase health-conscious management of HIV disease. 坚持治疗、健康知识普及和参与护理之间的关系：如何提高对艾滋病的健康管理意识。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-02-01 Epub Date: 2024-11-05 DOI: 10.1177/09564624241297838

Valentina Massaroni, Valentina Delle Donne, Pierluigi Francesco Salvo, Damiano Farinacci, Valentina Iannone, Gianmaria Baldin, Nicoletta Ciccarelli, Simona Di Giambenedetto

{"title":"Association among therapeutic adherence, health literacy, and engagement in care: How to increase health-conscious management of HIV disease.","authors":"Valentina Massaroni, Valentina Delle Donne, Pierluigi Francesco Salvo, Damiano Farinacci, Valentina Iannone, Gianmaria Baldin, Nicoletta Ciccarelli, Simona Di Giambenedetto","doi":"10.1177/09564624241297838","DOIUrl":"10.1177/09564624241297838","url":null,"abstract":"Background: In the context of People Living with HIV (PLWH), poor health literacy (HL) seems to be linked to poorer health outcomes and reduced engagement in care. Additionally, the level of HL can affect HIV knowledge and may impact adherence to antiretroviral therapy (ART). This research explored the connection between ART adherence, HL, and engagement in care in a cohort of 250 PLWH receiving ART in Italy.Methods: A questionnaire was given to PLWH at Policlinico Gemelli in Rome to assess their health literacy and adherence to therapy. The Brief Health Literacy Screening (BHLS) and the Newest Vital Sign (NVS) were used to evaluate subjective and objective HL. Adherence levels were self-reported as poor, good, or excellent, and the assessment included the Patient Health Engagement Scale (PHE-S).Results: Notably, the majority of the sample comprised male individuals (67.9%), with 69.2% reporting a 10-years or longer duration between their HIV diagnosis and their initiation of ART. It was found that PLWH with poor adherence had low schooling, had been living with HIV for 1-5 years, were HCV co-infected, had a viremia >50 copies/mL, poor health status, poor engagement in care, and poor HL (p = <0.001). They exhibited lower mean scores on the subjective HL scale and lower CD4 T-cell counts and nadir CD4 T-cell counts (p < .001).Conclusion: Our study demonstrated a positive correlation between higher HL levels and improved disease management, treatment adherence, and overall physical and mental well-being. Enhanced HL capabilities are paramount in bolstering health management and treatment adherence.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"132-140"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case series of two persons living with HIV with detectable viral loads initiated then suppressed on cabotegravir/rilpivirine with lenacapavir. 两名检测到病毒载量的艾滋病病毒感染者的病例系列，他们开始使用卡博特拉韦/利匹韦林联合来那卡韦治疗，随后病情得到抑制。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-02-01 Epub Date: 2024-10-03 DOI: 10.1177/09564624241288293

Kimberly L O'Neil, Patrick R Ching, Robert T Higginson, Patricia Pecora Fulco

{"title":"Case series of two persons living with HIV with detectable viral loads initiated then suppressed on cabotegravir/rilpivirine with lenacapavir.","authors":"Kimberly L O'Neil, Patrick R Ching, Robert T Higginson, Patricia Pecora Fulco","doi":"10.1177/09564624241288293","DOIUrl":"10.1177/09564624241288293","url":null,"abstract":"Long-acting (LA) cabotegravir/rilpivirine (CAB/RPV) is primarily prescribed for virologically suppressed persons living with HIV (PLWH). Patients experiencing pill dysphagia or profound adherence challenges were excluded from the phase 3 studies, but recent reports demonstrate successful treatment in PWLH with baseline viremia. We describe two PLWH with detectable viral loads (VL) with multidrug resistance mutations. They were unable to sustain virologic suppression on oral therapy with historical poor adherence and dysphagia. Initiation of intramuscular CAB/RPV with subcutaneous lenacapavir (LEN) injections was necessary with baseline resistance. Due to anorexia and a low muscle mass, one patient received CAB/RPV injections in the vastus lateralis rather than the gluteal muscle with a 67-day delay between injections three and four due to health challenges. Both achieved viral suppression on monthly CAB/RPV with LEN. A return to health with a BMI increase from <14 kg/m2 to almost 17 kg/m2 resulted in the second patient. Injectable LA ART (CAB/RPV + LEN) in PLWH with detectable viremia results in sustained virologic suppression and a return to health and should now be considered a novel option for MDR patients with an inability to adhere to oral regimens.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"155-157"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

British Association of Sexual Health and HIV UK national guideline for the management of anogenital herpes, 2024. 英国性健康和艾滋病协会《2024 年英国肛门疱疹管理国家指南》。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-02-01 Epub Date: 2024-10-07 DOI: 10.1177/09564624241282396

Raj Patel, John Green, Benjamin Moran, Emily Clarke, Kanchana Seneviratne, Ceri Evans, Felicity Young, Marian Nicholson, Emanuela Pelosi, Margaret Kingston, Elizabeth Foley

引用次数: 0

Improving sustainability in sexual health: A pilot project reintroducing reusable stainless steel vaginal specula at a sexual health clinic. 提高性健康的可持续性：在性健康诊所重新引入可重复使用不锈钢阴道窥器的试点项目。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-02-01 Epub Date: 2024-11-05 DOI: 10.1177/09564624241298873

Isobel Hall, Gillian Dean, Amanda Clarke

{"title":"Improving sustainability in sexual health: A pilot project reintroducing reusable stainless steel vaginal specula at a sexual health clinic.","authors":"Isobel Hall, Gillian Dean, Amanda Clarke","doi":"10.1177/09564624241298873","DOIUrl":"10.1177/09564624241298873","url":null,"abstract":"Introduction: In line with the NHS net zero initiative, University Hospitals Sussex (UHS) committed to a Green Plan which included the introduction of reusable instruments. Following positive responses from a staff and patient survey in 2021, the sexual health and contraception (SHAC) department began a pilot scheme of 100 medium size reusable stainless steel vaginal specula (RMS) as an alternative to disposable acrylic models. The aim was to determine outcomes regarding sustainability goals and clinician experiences.Methods: Estimated carbon footprint and cost was calculated for actual use during study period, and expected use if RMS were to be exclusively used in the future. A staff questionnaire was distributed to ascertain attitudes towards RMS, including obstacles to their use and how these might be overcome.Results: Monthly medium size plastic specula use decreased during the pilot, resulting in a 22.4% reduction in carbon footprint. Exclusively using RMS for all examinations could reduce carbon emissions by 85.6%. Clinicians had an overall positive attitude towards RMS. Key obstacles to use were poorly stocked rooms and insufficient variety of size.Discussion: The success of this pilot scheme is being built upon by investing in a greater variety of sizes of RMS for use in SHAC aiming for a 100% reusable system.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"151-154"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of concurrent HIV-infection on women with vulvar cancer: Comparison of clinical characteristics and outcome. 同时感染艾滋病毒对女性外阴癌患者的影响：比较临床特征和结果。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-02-01 Epub Date: 2024-10-03 DOI: 10.1177/09564624241287260

Jennifer L Butt, Judith S Jacobsen, Hannah M Simonds, Matthys H Botha

{"title":"The impact of concurrent HIV-infection on women with vulvar cancer: Comparison of clinical characteristics and outcome.","authors":"Jennifer L Butt, Judith S Jacobsen, Hannah M Simonds, Matthys H Botha","doi":"10.1177/09564624241287260","DOIUrl":"10.1177/09564624241287260","url":null,"abstract":"Background: HPV-related vulvar cancer is increasing in prevalence, especially in women living with HIV. Treatment of vulva cancer is based on evidence from HPV-independent cancers, which affect older women. The impact of HIV on vulvar cancer characteristics and treatment outcomes needs to be elucidated.Patients and methods: A retrospective observational study compared the clinical characteristics, treatment, and outcomes of 92 HIV-positive and 131 HIV-negative women with vulvar cancer at our institution. Using descriptive statistics, HIV-positive and negative patients were compared and Cox regression models were tested for differences in mortality and recurrence.Results: HIV-positive patients were 20 years younger than HIV-negative patients (p < 0.001). More than 50% of patients presented with advanced stage cancer, however this was independent of HIV-status. Although HIV infection was associated with poorer survival (p = 0.022); rates of cure (p = 0.933) and recurrence rates (p = 0.8) were similar in HIV-positive and negative women.Conclusions: Vulvar cancer occurs at a much younger age in women living with HIV. Awareness among HIV-positive women and health care providers would lead to diagnosis of vulvar cancer at an earlier stage. Treatment protocols for HPV-related vulvar cancer should not be altered due to HIV status and should take into consideration the young age of the patients.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"106-113"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of depression prevalence in pregnant women living with HIV aged 18 years and older: A meta-analysis study.

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2025-01-28 DOI: 10.1177/09564624251316048

Sibel Gürbüz, Elif Nur Yildirim Öztürk, Simge Sari, Saliha Kazci, Meltem Çöl

{"title":"Determination of depression prevalence in pregnant women living with HIV aged 18 years and older: A meta-analysis study.","authors":"Sibel Gürbüz, Elif Nur Yildirim Öztürk, Simge Sari, Saliha Kazci, Meltem Çöl","doi":"10.1177/09564624251316048","DOIUrl":"https://doi.org/10.1177/09564624251316048","url":null,"abstract":"Background: Pregnant women living with HIV are known to be at higher risk of depression than pregnant women without HIV. Accompanied by a systematic literature review, the aim of this study was to determine the global prevalence of depression in pregnant women living with HIV.Methods: PubMed, Scopus, Google Scholar and Web of Science databases were searched. The references of the included publications and a similar meta-analysis study were also reviewed. The 19 included studies were assessed for quality using standard forms. Pooled prevalence was calculated using a random effects model. Heterogeneity and publication bias were assessed using various methods. Subgroup analyses and meta-regression were also performed.Results: Of the 19 studies included in the review, six of the studies were published between 2008 and 2014, and 13 were published between 2017 and 2023. 15 studies were conducted in African countries. According to study type, eight studies were cross-sectional and seven were cohort studies. The pooled prevalence of depression was calculated to be 45%. The prevalence in African countries was 37.7%. The studies were found to be statistically significantly heterogeneous. Tests and funnel plots showed no publication bias in this meta-analysis. The variables place, study type and scale made the model significant in the meta-regression.Conclusion: In this meta-analysis, 6379 women aged 18 years and older were examined and their depression levels were found to be high. Taking steps to struggle with HIV and depression in people living with HIV seems important.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251316048"},"PeriodicalIF":1.4,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0