International Journal of STD & AIDS最新文献

{"title":"Exploring mpox vaccination uptake and tolerability among people living with HIV: A study in an infectious disease unit in Italy.","authors":"Samuele Gaggioli, Giuseppe Formica, Valentina Petrini, Alessandra Russo Krauss, Paola Corsi, Alessandro Di Felice, Costanza Fiorelli, Elisabetta Mantengoli, Costanza Malcontenti, Emanuela Francalanci, Giulia Modi, Michele Trotta, Seble Tekle Kiros, Elena Gazzarri, Nicoletta Zocco, Lorenzo Zammarchi, Alessandro Bartoloni, Filippo Lagi","doi":"10.1177/09564624251349888","DOIUrl":"10.1177/09564624251349888","url":null,"abstract":"<p><p>BackgroundA live attenuated non-replicating vaccine (MVA-BN) is approved for immunization against mpox. We provide an overview of the uptake and tolerability of mpox vaccination among people living with HIV (PLWH) in a single centre in Italy and draw comparisons to individuals without HIV.MethodsWe retrospectively collected clinical data of people vaccinated with MVA-BN in a tertiary-level hospital in Florence, Italy. Baseline data were collected from pre-vaccination screening questionnaires; adverse events data were collected before the second dose through another dedicated questionnaire.ResultsWe vaccinated 332 subjects. Of them, 36.1% (<i>n</i> = 120) were PLWH, with higher median age, higher rate of previous smallpox vaccination and a higher proportion of transgender individuals compared to people without HIV. As for vaccine tolerability, subcutaneous administration was associated with significantly fewer adverse events than intradermal. There were no significant differences in tolerability between PLWH and individuals without HIV. Among people who did not complete the vaccine cycle, migrant and sex worker populations were disproportionately represented.ConclusionOur experience suggests that mpox vaccination has been accepted and well-tolerated in individuals with and without HIV. More work is needed to conduct immunization campaigns in marginalized populations such as migrants and sex workers.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"816-821"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the hidden epidemic: A scoping review of sexually transmitted diseases in Southeast Asia.","authors":"Nazri Che Dom, Rahmat Dapari, Mohamad Adzrin Harith Mohamad Syahriman, Adam Adha Mohd Sukri, Nur Leiza Azwa Kamarudin, Nur Shuhada Aqilah Ahmad Bakhtiar, Nur Syabila Alya Khairi, Nopadol Precha, Wan Shahriman Yushdie Wan Yusoff","doi":"10.1177/09564624251349598","DOIUrl":"10.1177/09564624251349598","url":null,"abstract":"<p><p><b>Background:</b> Sexually transmitted diseases (STDs) pose a significant global health challenge, with Southeast Asia bearing a disproportionately high burden due to socio-demographic vulnerabilities, disparities in healthcare access, and prevailing cultural stigmas. Despite growing research interest in the region, a comprehensive synthesis of disease burden, risk factors, and intervention strategies remains limited.<b>Objectives:</b> This study aimed to systematically review research trends, study populations, and pathogen distributions of STDs in Southeast Asia to identify evidence gaps and inform future policy and intervention strategies.<b>Methods:</b> A systematic literature search was conducted using Scopus, Web of Science, and PubMed databases in accordance with PRISMA guidelines. Eligible studies were those focusing on STDs in Southeast Asia and included high-risk populations such as men who have sex with men (MSM), sex workers, youth, heterosexual men and women, transgender individuals, and people living with HIV (PLHIV). The review encompassed key STDs including HIV/AIDS, syphilis, gonorrhea, chlamydia, HPV, trichomoniasis, and hepatitis B & C.<b>Results:</b> From 2,867 records, 58 studies met the inclusion criteria. HIV/AIDS was the most frequently studied STD (80%), while bacterial STDs and transgender populations were significantly underrepresented. Most studies employed cross-sectional designs (60%), with few longitudinal or interventional studies. Geographically, research was concentrated in Malaysia, Thailand, and Singapore, with limited representation from Cambodia, Vietnam, and Indonesia.<b>Discussion:</b> The findings underscore substantial research gaps, particularly in bacterial STDs, studies involving heterosexual and transgender populations, and the application of intervention-based designs. Inconsistencies in reporting standards and population definitions further limit the comparability of findings across studies.<b>Conclusion:</b> This review highlights the need for more inclusive and methodologically diverse research on STDs in Southeast Asia. Future efforts should prioritize standardized data collection frameworks, improved surveillance systems, and greater emphasis on intervention studies to strengthen evidence-based public health responses in the region.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"765-775"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox in Eastern Europe: Clinical findings from a Polish case series.","authors":"Monika Wiczuk-Wiczewska, Gabriela Korzańska, Karolina Adamczyk, Martyna Maryniowska, Bartosz Duczyński, Maciej Kuświk, Iwona Mozer-Lisewska","doi":"10.1177/09564624251370788","DOIUrl":"https://doi.org/10.1177/09564624251370788","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251370788"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with sexually transmitted reinfections, number of sexual partners and condom use among previously infected young people.","authors":"Isobel Landray, James R Carpenter, Sima Berendes, Melissa J Palmer, Caroline Free","doi":"10.1177/09564624251348693","DOIUrl":"10.1177/09564624251348693","url":null,"abstract":"<p><p>BackgroundSexually transmitted infections (STIs) are prevalent in young people. Digital interventions promoting safer sexual behaviours are low-cost and scalable. We use data from a randomised controlled trial of one such potential intervention (safetxt) to investigate factors associated with STI reinfection and risky sexual behaviours.MethodsWe use data from 6248 young people with STIs recruited from 92 UK sexual health clinics. Multivariable logistic regression models were developed with the outcomes: reinfection, condom use at last sex and number of sexual partners (≤1 or >1) at 1 year. A pre-specified variable selection process assessed effects of sociodemographic and sexual behaviour factors measured at trial baseline.ResultsFactors associated with reinfection included sexuality, ethnicity, baseline diagnosis of gonorrhoea and chlamydia, index of multiple deprivation, whether the participant and/or the last new partner tested before sex. Risk factors for condom use at last sex and number of sexual partners included sexuality and education level. The multivariable models had good calibration but poor discrimination.ConclusionsIn this large sample with good representation across social and ethnic groups, we identified patient characteristics associated with higher risk of reinfection. Improved understanding of factors associated with reinfections and higher-risk sexual behaviours can aid development of interventions.Trial RegistrationISRCTN64390461.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"808-815"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"British Association for Sexual Health and HIV (BASHH) UK national guideline for the use of doxycycline post-exposure prophylaxis (DoxyPEP) for the prevention of syphilis, 2025.","authors":"John Saunders, Joseph Deering, Claire Dewsnap, Rachel Drayton, John Gilmore, Alison Grant, Dwayne-Wilson Hunt, Manik Kohli, Fiona Lyons, Hamish Mohammed, Phil Samba, Benjamin Weil, John White, Nicholas Medland, Helen Fifer","doi":"10.1177/09564624251352053","DOIUrl":"10.1177/09564624251352053","url":null,"abstract":"<p><p>This guideline provides evidence-based recommendations for the use of doxycycline post exposure prophylaxis (doxyPEP) for the prevention of syphilis. DoxyPEP should be part of a comprehensive approach to the prevention of STIs, along with condom use, appropriate HIV prevention interventions, vaccination, STI testing, treatment and management, and appropriate risk reduction advice and psychological interventions if indicated.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"756-764"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sex-based differences in testing practices on <i>C</i><i>hlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> infection rates in military service members.","authors":"David M Aleman-Reyes, James K Aden, Miguel A Arroyo, Joseph E Marcus","doi":"10.1177/09564624251371827","DOIUrl":"https://doi.org/10.1177/09564624251371827","url":null,"abstract":"<p><p>Background<i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> infections impose a significant burden to the military. In previous studies, women service members had higher rates of both these infections as compared to men for unclear reasons. This study evaluated if sex-based differences in infection rates for chlamydia and gonorrhea were due to sex-based differences in testing practices.MethodsA retrospective chart review was conducted on military service members who underwent testing for chlamydia and gonorrhea at Joint Base San Antonio between June 1, 2023 and September 31, 2023. The local electronic health record database was queried to determine patient demographics, clinical setting, indications for testing, and positivity rates.ResultsA total of 1620 (43%) patients were included for analysis. The cohort was predominantly women (67.5%) and enlisted (84.2%) with a median age of 27 years [IQR: 23-32]. Men were more likely to be tested for patient driven factors, such as symptoms (41.2%) or patient request (24.5%). Women were most frequently tested due to clinical algorithm (53.0%). Men were more likely to test positive for both chlamydia (8.7% vs 3.9%, <i>p</i> = <0.001) and gonorrhea (2.8% vs 0.4%, <i>p</i> = <0.001).ConclusionsAlthough women were more frequently tested for chlamydia and gonorrhea infections, men had significantly higher positivity rates, with more patient-driven indications for testing. The result of this study implies that sex-based testing practice differences in our study population might partially account for the higher rates in men. Importantly, it supports the need for future studies to evaluate the effectiveness of screening men in military settings.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251371827"},"PeriodicalIF":1.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world persistence of bictegravir versus dolutegravir single-tablet regimens: A retrospective cohort study in a large urban Canadian HIV clinic.","authors":"Mona Loutfy, Negin Masoudifar, Jennifer McCully, Angela Underhill, V Logan Kennedy, Dileesha Fernando, Dylana Mumm, Taban Saifi, Hugh Ngo, Soodi Navadeh, Graham Smith","doi":"10.1177/09564624251371800","DOIUrl":"https://doi.org/10.1177/09564624251371800","url":null,"abstract":"<p><p>BackgroundSingle-tablet regimens (STRs) with integrase inhibitors, bictegravir (BIC) or dolutegravir (DTG), are favored in HIV treatment for their efficacy and convenience. This study compares persistence-time from initiation to discontinuation-between BIC/emtricitabine (FTC)/tenofovir alafenamide (TAF) and DTG-containing STRs at a Toronto HIV clinic<b>.</b>MethodsA retrospective cohort analysis was conducted on 1732 adults with HIV at Maple Leaf Medical Clinic who initiated or switched to BIC/FTC/TAF or DTG-containing STRs from 2016 to 2022. Persistence was measured in days until discontinuation. Kaplan-Meier curves and Cox models evaluated time-to-discontinuation and associated risks. Reasons for discontinuation were categorized into adverse events, patient preference, cost, compliance, physician preference, virologic failure, and others.ResultsAmong 1732 participants (median age 48 years, 88.7% cisgender men), 387 (22.3%) discontinued their STRs after a median of 402 days. BIC/FTC/TAF had a lower discontinuation rate (18.9%) compared to DTG-containing STRs (29.9%) (HR = 0.74, 95% CI: 0.60-0.92). Adverse events were the primary reason for discontinuation, with BIC having lower rates (9.6% vs. 12.5% for DTG).DiscussionBIC/FTC/TAF demonstrated higher persistence and fewer adverse events than DTG-containing STRs, aiding personalized HIV treatment decisions for better long-term outcomes.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251371800"},"PeriodicalIF":1.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beard folliculitis by <i>Klebsiella aerogenes</i> in a young man: An emergent sexually transmitted infection?","authors":"Noelia García Muñoz, Alberto Sáez Vicente, Luis Feito Sancho, Abraham Santa Cruz Martín, Marta Folcrá González, Eloy José Tarín Vicente, Iolanda Prats Caelles","doi":"10.1177/09564624251369576","DOIUrl":"https://doi.org/10.1177/09564624251369576","url":null,"abstract":"<p><p>Beard folliculitis is a frequent dermatologic complaint, but uncommon pathogens may challenge diagnosis and treatment. We report a case of persistent beard folliculitis in a 23-year-old man who has sex with men (MSM), unresponsive to conventional therapies. Culture of a pustule identified <i>Klebsiella aerogenes</i>, a Gram-negative enteric bacillus increasingly implicated in beard folliculitis in MSM. Combined oral and topical antibiotic therapy targeting <i>K. aerogenes</i> achieved full resolution. Differential diagnosis included <i>tinea barbae</i> caused by <i>Trichophyton mentagrophytes</i> ITS genotype VII, an emerging sexually transmitted dermatophyte with similar demographics and presentation. This case adds to a growing number of reports linking <i>K. aerogenes</i> to folliculitis in MSM, underlines the importance of bacterial culture in recalcitrant folliculitis, and raises awareness of <i>K. aerogenes</i> as a potential sexually transmissible pathogen. Prolonged therapy and avoidance of possible environmental reservoirs such as hot tubs may be necessary to prevent recurrence.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251369576"},"PeriodicalIF":1.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive at-home sexually transmitted and blood borne infection (STBBI) testing program: A pilot study.","authors":"Brandon L Christensen, Chantal L Rytz, Jason E Black, Grace Kwon, Nolan E Hill, Pam Krause, Kevin Fonseca, Myles Leslie, Deirdre L Church, Christopher T Naugler, Phillip Lacap, John Kim, Caley B Shukalek, Ranjani Somayaji","doi":"10.1177/09564624251371793","DOIUrl":"https://doi.org/10.1177/09564624251371793","url":null,"abstract":"<p><p>BackgroundRates of sexually transmitted and blood borne infections (STBBI) are rapidly increasing. Despite the high diagnostic accuracy of self-testing, no fully remote STBBI testing programs are available in Canada. We aimed to evaluate the feasibility and acceptability of a fully-remote, web-based, at-home STBBI testing (self-collection) program in Calgary, Canada.MethodsParticipants who were Alberta residents aged ≥16 years self-enrolled into a web-based platform between February 2023 and March 2024 and completed consent and intake questionnaires consisting of demographic and sexual health data. Kits were mailed, and samples were self-collected including swabs, urine and dried blood spot cards. Results of processed kits were communicated securely to participants. Surveys to assess the feasibility and acceptability of the process were completed.ResultsOf the 156 participants (39.7% men, 37.3 ± 10.5 years) from diverse sex and gender backgrounds who completed the intake, 43% (<i>n</i> = 67) participants returned their testing kits. In the cohort, there was low reported condom use in more than 50%, and 40% had not had STBBI testing in the past 12 months. There were six participants (9.0%) with new positive tests for an STBBI and all were connected with appropriate treatment. Participants largely reported satisfaction with the web-based platform and testing process as well as ease with testing modalities with the except for dried blood spot testing which presented collection challenges.ConclusionsOur web-based comprehensive testing pilot was feasible and acceptable, demonstrating the value of such remote approaches to diminishing the threat of rising STBBI rates.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251371793"},"PeriodicalIF":1.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thinking beyond the tablet: Acceptability of different HIV-PrEP modalities among GBMSM and gender-diverse individuals having sex with men in the UK.","authors":"Dana Ogaz, Natasha Ratna, Hridhya Vijayan, Stephanie J Migchelsen, David Reid, Dolores Mullen, Dawn Phillips, Eleanor Bell, Tamara Djuretic, Will Nutland, Catherine H Mercer, Kate Folkard, John Saunders, Hamish Mohammed","doi":"10.1177/09564624251369093","DOIUrl":"https://doi.org/10.1177/09564624251369093","url":null,"abstract":"<p><p>BackgroundHIV-PrEP is a key component of HIV combination prevention and has been routinely available through oral formulations (i.e. oral tablets) across sexual health services (SHSs) in the UK since 2020. We used data from a large, online community survey to assess the acceptability and preference of different HIV-PrEP modalities among gay, bisexual, and other men who have sex with men (GBMSM) and gender-diverse individuals living in the UK.MethodsUsing data collected from the 'Reducing inequalities in Sexual Health' (RiiSH) survey, an online community survey of 1106 GBMSM and gender-diverse individuals having sex with men (November/December 2023), we performed a secondary analysis examining HIV-PrEP modality acceptability and preference (e.g. oral, long acting injectable, gel, or patch) (%) by HIV-PrEP history (never, in lookback period of last 3-4 months since survey completion). Where ≥2 modalities were indicated, participants were asked to specify a single preferred modality. Single choice options were assumed to be the preferred HIV-PrEP modality.ResultsIrrespective of HIV-PrEP history, long acting injectables were highly acceptable (>70%) and the preferred modality (58% [222/386] by those never having used HIV-PrEP, 73% [75/103] in those without HIV-PrEP use in the lookback, 74% [314/424] in those with HIV-PrEP use in the lookback).ConclusionsWe found high acceptability of the use of injectables, with general preference over oral tablets. If injectable HIV-PrEP becomes available at SHSs in England, these modalities could have positive impacts on HIV-PrEP delivery, use, and access.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251369093"},"PeriodicalIF":1.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}