{"title":"Follmann's balanitis: An heterogeneous clinical manifestation of primary syphilis.","authors":"Jorge Pérez Garcia, Patricia Álvarez-Lopez, Juliana Esperalba, Vicente Descalzo, Maider Arando","doi":"10.1177/09564624251338657","DOIUrl":"10.1177/09564624251338657","url":null,"abstract":"<p><p>BackgroundSexually transmitted infections (STIs) rates have increased in the last two decades in Western world, including syphilis. Higher rates of syphilis lead to the emergence of atypical or less common manifestations like Follmann's balanitis. Follmann's balanitis is an atypical presentation of primary syphilis characterized as erythematous, erosive lesions on the glans penis.MethodsThe aim of the study is to describe the cases of the Follmann 's diagnosed in Vall d'Hebron-Drassanes STI Unit over 20 years (2003-2023). Retrospectively, the epidemiological, clinical and microbiological data were collected.ResultsIn total 20 cases of Follmann's balanitis were diagnosed. The clinical presentation was heterogeneous, with erosive balanitis being the most frequent presentation. Fifteen per cent had also a chancre and 50% presented with lymphadenopathy. Dark field microscopy and <i>Treponema pallidum</i> NAAT were positive in 41% and 92% respectively, and the median RPR titre was 1/4 (IQR 1/2-1/16).ConclusionsFollmann's balanitis is a rare presentation of primary syphilis which has to be suspected in case of erosive balanitis, especially in key populations as MSM or persons with previous STIs, where syphilis is more frequent.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"700-704"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disseminated cutaneous leishmaniasis in a person living with HIV.","authors":"Meryem Soughi, Samira Rabhi, Mouna Guechchati, Zakia Douhi, Sara Elloudi, Hanane Baybay, Fatima Zahra Mernissi","doi":"10.1177/09564624251344435","DOIUrl":"10.1177/09564624251344435","url":null,"abstract":"<p><p>Leishmaniasis is a tropical disease caused by protozoa belonging to the group of <i>Leishmania</i> species. Visceral leishmaniasis, diffuse cutaneous leishmaniasis, and atypical forms of cutaneous leishmaniasis are common in acquiring HIV. We report a case of atypical cutaneous leishmaniasis (CL) in a person living with HIV.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"731-733"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shanna L Burke, Adrienne Grudzien, Tan Li, Stephanie Garcia, Sabrina Sales Martinez, Emily Jurich, Daniel R Jimenez, Jacqueline Hernández, Qingyun Liu, Tahirah A Tyrell, Natalie Goulett, Adriana L Campa, Zoran Bursac, Marianna K Baum
{"title":"The influence of socioeconomic factors and apolipoprotein ε genotype on cognitive outcomes in a multi-ethnic sample living with HCV and HIV.","authors":"Shanna L Burke, Adrienne Grudzien, Tan Li, Stephanie Garcia, Sabrina Sales Martinez, Emily Jurich, Daniel R Jimenez, Jacqueline Hernández, Qingyun Liu, Tahirah A Tyrell, Natalie Goulett, Adriana L Campa, Zoran Bursac, Marianna K Baum","doi":"10.1177/09564624251324968","DOIUrl":"10.1177/09564624251324968","url":null,"abstract":"<p><p>BackgroundThis study examined associations between apolipoprotein (APOE) ε4 carrier status and Mini-Mental State Examination (MMSE) scores and whether this relationship varied among adults living with HIV/HCV, HIV, HCV, or neither. We also examined whether sociodemographic factors moderated associations between APOE ε4 carrier status and MMSE scores.MethodsA secondary analysis of cognitive, psychological, and sociodemographic data from the Miami Adult Studies on HIV (MASH) cohort (<i>n</i> = 493) was completed. Banked blood samples underwent APOE genotyping. Bivariate analyses examined potential differences across participants by HIV and/or HCV statuses and by APOE ε4 carrier status. Multiple linear regression was conducted to test the adjusted moderation effect of each sociodemographic variable between APOE ε4 carrier status and MMSE scores within each group.ResultsSociodemographic factors, such as income, education, food insecurity, and employment influenced associations between APOE ε4 carrier status and MMSE scores among participants with HIV/HCV. Participants with APOE ε4 genotypes living with HCV had higher MMSE scores than non-APOE ε4 carriers.ConclusionThese results reinforce the need for future studies examining (1) the impact of APOE genotype on cognitive functioning while considering socioeconomic factors and (2) the influence of socioeconomic factors on cognitive scores among individuals living with HIV and or HCV.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"719-730"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicolas Laverde-Sudupe, Angela Lizeth Giraldo-Serna, Mariana Vasquez-Amaya, Fabián Carrera-Patiño
{"title":"Visceral and cutaneous leishmaniasis in a person living with HIV.","authors":"Nicolas Laverde-Sudupe, Angela Lizeth Giraldo-Serna, Mariana Vasquez-Amaya, Fabián Carrera-Patiño","doi":"10.1177/09564624251346029","DOIUrl":"10.1177/09564624251346029","url":null,"abstract":"<p><p>Leishmaniasis, the third most common parasitic infection in persons living with HIV, typically presents in cutaneous, mucocutaneous, or visceral forms. This case report describes a 24-year-old male with advanced HIV/AIDS (CD4+ count 3 cells/mm<sup>3</sup>) who presented with neurological deterioration due to cerebral toxoplasmosis. During hospitalization, he developed atypical genital ulcers and persistent pancytopenia. Bone marrow examination revealed amastigotes consistent with <i>Leishmania</i> spp., indicating concurrent visceral and mucocutaneous leishmaniasis. Treatment with liposomal amphotericin B followed by miltefosine resulted in clinical improvement of the genital ulcers. This case highlights the atypical presentation of leishmaniasis in a patient living with HIV, deviating from classic descriptions and underscoring the diagnostic challenges. The presence of <i>Leishmania</i> amastigotes in the bone marrow, coupled with unusual cutaneous manifestations, emphasizes the need for a high index of suspicion for opportunistic infections in patients living with HIV/AIDS with unexplained findings, even without a history of travel to endemic areas. Timely diagnosis through bone marrow examination and appropriate multi-drug therapy are crucial for managing such complex co-infections.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"734-737"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vespasiano Gonzaga, founder of Sabbioneta, and his Renaissance disease.","authors":"Gianluca Nazzaro","doi":"10.1177/09564624251347419","DOIUrl":"10.1177/09564624251347419","url":null,"abstract":"","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"749-751"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeffrey Man Hay Wong, Gal Av-Gay, Terry Lee, Arezou Azampanah, Chelsea Elwood, Julie van Schalkwyk, Laura Sauvé, Deborah Money
{"title":"Sexually transmitted infections and bacterial vaginosis and preterm birth in pregnant people living with HIV: A population-based cohort study.","authors":"Jeffrey Man Hay Wong, Gal Av-Gay, Terry Lee, Arezou Azampanah, Chelsea Elwood, Julie van Schalkwyk, Laura Sauvé, Deborah Money","doi":"10.1177/09564624251347458","DOIUrl":"10.1177/09564624251347458","url":null,"abstract":"<p><p>BackgroundWhile individual sexually transmitted infections are linked with preterm births, their synergistic impact among pregnant people living with HIV (PLWH) remain unclear. We aimed to identify the impact of antenatal sexually transmitted infections and bacterial vaginosis on preterm birth in PLWH.MethodsWe completed a population-based cohort study using the British Columbia Perinatal HIV Surveillance Database, capturing all births in PLWH from January 1997 to December 2022. Univariate risk factors for preterm birth were identified using chi-squared tests, Fisher's exact tests and t-tests, followed by a multivariate logistic regression analysis.ResultsOf 578 singleton pregnancies, 111 (19.2%) had preterm births, of which 34 (31%) delivered before 34 weeks gestational age. In our population, 11% were identified with a sexually transmitted infection or bacterial vaginosis (STIBV) in pregnancy. The preterm birth rate in PLWH with antenatal STIBV was 37% compared to 17% in PLWH without STIBV (OR: 2.18; 95% CI (1.50 - 3.16); <i>p</i> = .0003). Preterm deliveries were more common in individuals with concurrent Hepatitis C (OR: 2.42; <i>p</i> < .0001), antenatal diagnosis of <i>Chlamydia</i> <i>trachomatis</i> (OR 2.17; <i>p</i> = .036), <i>Trichomonas</i> <i>vaginalis</i> (OR: 2.78; <i>p</i> < .001) and bacterial vaginosis (OR: 2.15; <i>p</i> = .003). After adjusting for ethnicity, history of preterm birth, substance use, concurrent Hepatitis C, CD4 count and viral suppression at delivery, STIBV remains an independent risk factor (OR: 2.09; 95% CI: 1.04 - 4.19; <i>p</i> = .039).ConclusionAmong PLWH, antenatal screening for sexually transmitted infections and bacterial vaginosis can identify individuals at the highest risk of preterm birth.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"712-718"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Islam Rajab, Ayman Khaled, Hammam Jallad, Ahmad Nouri, Mohamed Elagami, Walid Baddoura, Qutayba Z Ayaseh
{"title":"Syphilitic proctitis mimicking ulcerative colitis in a person living with HIV.","authors":"Islam Rajab, Ayman Khaled, Hammam Jallad, Ahmad Nouri, Mohamed Elagami, Walid Baddoura, Qutayba Z Ayaseh","doi":"10.1177/09564624251363480","DOIUrl":"https://doi.org/10.1177/09564624251363480","url":null,"abstract":"<p><p>Syphilitic proctitis is a rare presentation of syphilis that can mimic IBD, posing a diagnostic challenge, especially in immunocompromised patients. We report the case of a 28-year-old transgender woman with a past medical history of ulcerative colitis, HIV, and syphilis, initially misdiagnosed with ulcerative colitis. Sigmoidoscopy showed a rectal ulcer; histology and positive syphilis serologies confirmed syphilitic proctitis. This case highlights the need to consider infectious causes in atypical or treatment-resistant proctitis, emphasising the value of a thorough history and targeted testing.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251363480"},"PeriodicalIF":1.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shatila Torabi, Naser Tayyebi Meibodi, Ali Rashtibaf, Zahra Rafiei Vardanjani
{"title":"Angiokeratoma of Fordyce: Two unusual case presentations involving lesions on the clitoris and glans penis.","authors":"Shatila Torabi, Naser Tayyebi Meibodi, Ali Rashtibaf, Zahra Rafiei Vardanjani","doi":"10.1177/09564624251359083","DOIUrl":"https://doi.org/10.1177/09564624251359083","url":null,"abstract":"<p><p>Angiokeratoma of Fordyce is a benign vascular lesion characterized by the dilation of blood vessels within the papillary dermis, accompanied by epidermal acanthosis and hyperkeratosis. This report presents two clinical cases: a 22-year-old woman with a solitary, prominent nodular lesion on the clitoris and a 26-year-old man with asymptomatic violaceous papules on the glans penis. Both cases underscore the clinical presentation, differential diagnoses, and histopathological findings associated with angiokeratoma. The first case was diagnosed through excisional biopsy, revealing orthohyperkeratosis, parakeratosis, and dilated vascular channels, while the second case was confirmed via punch biopsy. Although angiokeratomas are typically asymptomatic, they may occasionally present with bleeding, highlighting the necessity for clinical vigilance. The rarity of these lesions in the genital region emphasizes the importance of accurate diagnosis and management, as they can mimic more serious conditions, including melanoma.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251359083"},"PeriodicalIF":1.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Novela, Bruno Silva, João Matos, Cláudia Pedrosa, Francisca Costa, Ana Cipriano
{"title":"HIV-related extracavitary primary effusion lymphoma presenting as a bronchial mass: Case report.","authors":"Francisco Novela, Bruno Silva, João Matos, Cláudia Pedrosa, Francisca Costa, Ana Cipriano","doi":"10.1177/09564624251362327","DOIUrl":"https://doi.org/10.1177/09564624251362327","url":null,"abstract":"<p><p>We describe a case of human herpesvirus-8 (HHV8) associated extracavitary primary effusion lymphoma (PEL) in a 52-year-old man who initially presented with long-term nonproductive cough, fever, night sweats and loss of weight. Initial blood tests were positive for human immunodeficiency virus (HIV) with CD4 + T-lymphocytes count of 42/mm3. Respiratory opportunistic diseases were excluded. Additional investigation with bronchoscopy revealed a bronchial mass that was biopsied. Histology and immunohistochemical tests confirmed extracavitary PEL associated with HHV-8. Antiretroviral treatment and CHOP regimen chemotherapy was initiated with an effective response. Given its rarity and unusual presentation, this clinical case emphasizes the importance of considering PEL, along with other lymphoproliferative disorders, as a differential diagnosis in patients living with HIV with acquired immune deficiency syndrome (AIDS) with a bronchial mass.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251362327"},"PeriodicalIF":1.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaiberth Antonio Cardona-Arias, Valeria Benítez Cadavid, Camilo Gallego Ramírez, Luis Felipe Higuita-Gutiérrez
{"title":"Incidence of HIV and its associated factors in blood donors from a hemocenter in Medellín, Colombia.","authors":"Jaiberth Antonio Cardona-Arias, Valeria Benítez Cadavid, Camilo Gallego Ramírez, Luis Felipe Higuita-Gutiérrez","doi":"10.1177/09564624251363460","DOIUrl":"https://doi.org/10.1177/09564624251363460","url":null,"abstract":"<p><p>IntroductionHuman Immunodeficiency Virus (HIV) infection remains a global public health concern due to its high morbidity and mortality rates, as well as the significant costs associated with treatment and healthcare services.ObjectiveTo determine the incidence of HIV and its associated factors among blood donors in the city of Medellín, Colombia.MethodsA longitudinal study was conducted using secondary data from 23,122 repeat blood donors at a blood bank in Medellín. The cumulative incidence was estimated along with its 95% confidence interval. Pearson's chi-square test, Fisher's exact test, and relative risk calculations were used to identify associated factors.ResultsThe HIV incidence was 9.1 per 10,000 donors (95% CI: 5.0-13.2). Subgroups with the highest incidence per 10,000 donors included those recruited through mobile blood drives (12.3), individuals under 40 years of age (12.0), men (11.3), and altruistic donors (10.6).ConclusionA relatively low number of new HIV cases was found among repeat donors. However, the identification of subgroups with higher incidence is critical for developing targeted strategies to ensure the safety of these priority populations and to enhance active epidemiological surveillance systems for HIV in the general population.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251363460"},"PeriodicalIF":1.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}