International Journal of STD & AIDS最新文献

{"title":"Long-term efficacy and safety of fixed-dose dolutegravir-lamivudine in people with HIV: A retrospective study from India.","authors":"Vinay Kulkarni, Ritu Parchure, Shridevi Gundu, Trupti Darak, Kailas Kurkute, Ketan Kulkarni","doi":"10.1177/09564624251352064","DOIUrl":"10.1177/09564624251352064","url":null,"abstract":"<p><p>BackgroundHIV continues to be a significant health concern across the world. Combination antiretroviral therapy (cART) comprising of three-drug regimens has improved clinical outcome but involves long-term toxicity concerns. Hence, to reduce drug exposure, interest in two-drug regimens has increased. This study evaluates the real-world efficacy and safety of a two-drug regimen that is a fixed-dose combination (FDC) of Dolutegravir 50 mg and Lamivudine 300 mg tablets in people living with HIV (PLHIV) in India.MethodsThe retrospective data included PLHIV aged ≥18 years, virally suppressed at baseline, and switched to DTG/3TC between November 2021 and April 2022. Patients were followed for 96 weeks, with routine clinical and laboratory assessments. Virological failure was defined as viral loads >1000 copies/mL, while safety assessments tracked adverse events (AEs), weight gain, and metabolic parameters.ResultsAmong 218 patients (mean age 48.08 ± 10.58 yrs), 97.8% achieved virological suppression at 96 weeks with sustained virological suppression at key time points (24, 48, 72, and 96 weeks). CD4 counts improved significantly (<i>p</i> = .002), specifically in females. Body weight increased moderately, with 16.28% experiencing ≥10% weight gain by 96 weeks. Minor statistically significant variations in cholesterol, triglycerides, and creatinine levels were observed. Nine patients discontinued DTG/3TC due to AEs, primarily weight gain and gastrointestinal issues.ConclusionThe study demonstrates that the DTG/3TC FDC is an effective, safe, and well-tolerated regimen for maintaining virological suppression in real-world settings, supporting its viable use as a switching strategy in reducing drug exposure and managing long-term toxicity.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352064"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of tenofovir alafenamide- or tenofovir disoproxil fumarate-containing regimens in adults with treatment-naïve HIV-hepatitis B co-infection.","authors":"Fehmi Tabak, Dilek Yıldız Sevgi, Esra Zerdali, Ahmet Furkan Kurt, Hayat Kumbasar Karaosmanoğlu, Meliha Meriç Koç, Alper Gunduz, Ahsen Öncül, İnci Yilmaz Nakir, Esra Canpolat Ünlü, Ozlem Altuntaş Aydın, Bilgul Mete","doi":"10.1177/09564624251352345","DOIUrl":"https://doi.org/10.1177/09564624251352345","url":null,"abstract":"<p><p>BackgroundHepatitis B (HBV) infection affects 4%-14% of people with HIV infection in Turkey. Tenofovir alafenamide (TAF) is highly effective in treatment of HIV infection. While it is active against HBV, data on the use in HIV-HBV co-infection are limited.Patients and MethodsWe analyzed the efficacy of tenofovir disoproxil fumarate (TDF)- and TAF-containing regimens in patients with HIV-HBV co-infection from six centers in Istanbul, Turkey. The results of the cohort of 36 months were presented.Results259 patients were enrolled: 146 and 113 were receiving TAF- and TDF-containing regimens respectively. Baseline characteristics were comparable except TAF-containing group was older; had higher CD4 cell count and lower rate of CD4 count ≤200 cells/μL. Baseline HIV-RNA were 8.2 log copies/mL and 6.8 log in TAF- and TDF-containing groups, respectively (<i>p</i> = .059) and HBV-DNA levels were 8.1 log IU/mL in both groups. Thirty-eight and 39% of the patients were HBeAg-positive. After 36 months, undetectable HBV-DNA was noted in 88% and 87%, and undetectable HIV-RNA in 85% and in 83% of TAF and TDF-containing groups, respectively. The increase in mean CD4 cell was significant in both groups: Δ = 311 cells/μL in TAF- and Δ = 393 cells/μL in TDF-containing groups. Rates of HBeAg loss (63% vs 57%), HBeAg seroconversion (35% vs 29%), HBsAg loss (29% vs 27%), and HBsAg seroconversion (23% vs 16%) were comparable at 36 months of therapy.ConclusionThis real-life study showed that both TAF- and TDF-containing regimens are effective in co-infected patients. The rates of HBsAg loss seemed higher than those in HBV-monoinfected patients.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352345"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring mpox vaccination uptake and tolerability among people living with HIV: A study in an infectious disease unit in Italy.","authors":"Samuele Gaggioli, Giuseppe Formica, Valentina Petrini, Alessandra Russo Krauss, Paola Corsi, Alessandro Di Felice, Costanza Fiorelli, Elisabetta Mantengoli, Costanza Malcontenti, Emanuela Francalanci, Giulia Modi, Michele Trotta, Seble Tekle Kiros, Elena Gazzarri, Nicoletta Zocco, Lorenzo Zammarchi, Alessandro Bartoloni, Filippo Lagi","doi":"10.1177/09564624251349888","DOIUrl":"https://doi.org/10.1177/09564624251349888","url":null,"abstract":"<p><p>BackgroundA live attenuated non-replicating vaccine (MVA-BN) is approved for immunization against mpox. We provide an overview of the uptake and tolerability of mpox vaccination among people living with HIV (PLWH) in a single centre in Italy and draw comparisons to individuals without HIV.MethodsWe retrospectively collected clinical data of people vaccinated with MVA-BN in a tertiary-level hospital in Florence, Italy. Baseline data were collected from pre-vaccination screening questionnaires; adverse events data were collected before the second dose through another dedicated questionnaire.ResultsWe vaccinated 332 subjects. Of them, 36.1% (<i>n</i> = 120) were PLWH, with higher median age, higher rate of previous smallpox vaccination and a higher proportion of transgender individuals compared to people without HIV. As for vaccine tolerability, subcutaneous administration was associated with significantly fewer adverse events than intradermal. There were no significant differences in tolerability between PLWH and individuals without HIV. Among people who did not complete the vaccine cycle, migrant and sex worker populations were disproportionately represented.ConclusionOur experience suggests that mpox vaccination has been accepted and well-tolerated in individuals with and without HIV. More work is needed to conduct immunization campaigns in marginalized populations such as migrants and sex workers.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251349888"},"PeriodicalIF":1.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"British Association for Sexual Health and HIV (BASHH) UK national guideline for the use of doxycycline post-exposure prophylaxis (DoxyPEP) for the prevention of syphilis, 2025.","authors":"John Saunders, Joseph Deering, Claire Dewsnap, Rachel Drayton, John Gilmore, Alison Grant, Dwayne-Wilson Hunt, Manik Kohli, Fiona Lyons, Hamish Mohammed, Phil Samba, Benjamin Weil, John White, Nicholas Medland, Helen Fifer","doi":"10.1177/09564624251352053","DOIUrl":"https://doi.org/10.1177/09564624251352053","url":null,"abstract":"<p><p>This guideline provides evidence-based recommendations for the use of doxycycline post exposure prophylaxis (doxyPEP) for the prevention of syphilis. DoxyPEP should be part of a comprehensive approach to the prevention of STIs, along with condom use, appropriate HIV prevention interventions, vaccination, STI testing, treatment and management, and appropriate risk reduction advice and psychological interventions if indicated.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251352053"},"PeriodicalIF":1.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C increases acute myocardial infarction risk in people living with HIV: A systematic review and meta-analysis.","authors":"Thanathip Suenghataiphorn, Narisara Tribhuddharat, Pojsakorn Danpanichkul, Thitiphan Srikulmontri, Narathorn Kulthamrongsri","doi":"10.1177/09564624251348688","DOIUrl":"https://doi.org/10.1177/09564624251348688","url":null,"abstract":"<p><p>BackgroundHepatitis C virus (HCV) coinfection is common among people living with HIV (PLWH) and is associated with adverse outcomes. However, the specific association between HCV coinfection and the risk of acute myocardial infarction (AMI) in PLWH remains unclear. This systematic review and meta-analysis aims to clarify this relationship.MethodWe searched MEDLINE and EMBASE databases from inception to October 2024 for cohort studies comparing the incidence of AMI in PLWH with HCV coinfection versus PLWH without HCV coinfection (HIV mono-infection). We used the generic inverse variance method with a random-effects model to pool risk ratios (RRs) and 95% confidence intervals (CIs). Heterogeneity was assessed using the I² statistic. All statistical analyses were performed using Review Manager 5.4.ResultsSeven cohort studies, encompassing 94,664 participants (mean age 42 years, 83% male), met the inclusion criteria. HCV coinfection was associated with a significantly increased risk of AMI in PLWH (pooled RR = 1.25, 95% CI: 1.09, 1.44; I² = 18%; <i>p</i> < .001) compared to HIV mono-infection. A subgroup analysis restricted to type 1 AMI was not statistically significant (pooled RR = 1.03, 95% CI: 0.84, 1.26; <i>p</i> = .78).ConclusionsHCV coinfection is associated with a significantly increased risk of AMI in PLWH. Further research is needed to determine the pathophysiology of this relationship.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251348688"},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, symptomology, and correlates of curable sexually transmitted infections among pregnant women in Eastern Cape, South Africa.","authors":"Natalie G Shaetonhodi, Alex de Voux, Chibuzor M Babalola, Dvora Joseph Davey, Mandisa M Mdingi, Ranjana M S Gigi, Remco P H Peters, Freedom Mukomana, Jeffrey D Klausner, Andrew Medina-Marino","doi":"10.1177/09564624251347484","DOIUrl":"https://doi.org/10.1177/09564624251347484","url":null,"abstract":"<p><p>BackgroundCurable sexually transmitted infections (STIs) contribute to adverse maternal and neonatal outcomes. Syndromic management is standard care in South Africa. We evaluated prevalence, symptomology, and correlates of curable STIs, among pregnant women in Eastern Cape, South Africa.MethodsWe conducted a cross-sectional analysis using baseline data from a randomized controlled trial of pregnant women attending their first antenatal care visit at public clinics in Buffalo City Municipality (2021-2024). Participants were tested for <i>Chlamydia (C.) trachomatis</i>, <i>Neisseria (N.) gonorrhoeae</i>, <i>Trichomonas (T.) vaginalis</i> using GeneXpert point-of-care tests and for syphilis using Alere Determine TP rapid test. Symptoms were self-reported and clinically-observed. Adjusted prevalence ratios were estimated using Poisson regression models with robust standard errors.ResultsAmong 1491 participants (median age: 28 years (IQR: 24-33); gestational age: 13 weeks (IQR: 8-18); HIV prevalence: 30%), STI prevalence was 27.6% (95% CI: 25.3-29.9): <i>C. trachomatis</i> 14.7%, <i>N. gonorrhea</i> 5%, <i>T. vaginalis</i> 10.2%, syphilis 3.4%. Women with HIV had higher STI prevalence (32.8% vs 25.3%, <i>p</i> = .003), particularly for <i>T. vaginalis</i> (17% vs 7.3%, <i>p</i> < .001); 20.1% of women with C<i>. trachomatis</i>, <i>N. gonorrhea</i>, and/or <i>T. vaginalis</i> were symptomatic, and 63% of symptomatic women tested STI-negative. Younger age, lower education, multiple sex partners and unknown HIV-serostatus of partners were associated with increased STI prevalence.ConclusionWe observed a high prevalence of STIs, particularly among women with HIV, with many asymptomatic cases; emphasizing the need for integrated point-of-care testing to ensure timely treatment, reduce antibiotic overuse, and improve maternal and neonatal outcomes.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251347484"},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with sexually transmitted reinfections, number of sexual partners and condom use among previously infected young people.","authors":"Isobel Landray, James R Carpenter, Sima Berendes, Melissa J Palmer, Caroline Free","doi":"10.1177/09564624251348693","DOIUrl":"https://doi.org/10.1177/09564624251348693","url":null,"abstract":"<p><p>BackgroundSexually transmitted infections (STIs) are prevalent in young people. Digital interventions promoting safer sexual behaviours are low-cost and scalable. We use data from a randomised controlled trial of one such potential intervention (safetxt) to investigate factors associated with STI reinfection and risky sexual behaviours.MethodsWe use data from 6248 young people with STIs recruited from 92 UK sexual health clinics. Multivariable logistic regression models were developed with the outcomes: reinfection, condom use at last sex and number of sexual partners (≤1 or >1) at 1 year. A pre-specified variable selection process assessed effects of sociodemographic and sexual behaviour factors measured at trial baseline.ResultsFactors associated with reinfection included sexuality, ethnicity, baseline diagnosis of gonorrhoea and chlamydia, index of multiple deprivation, whether the participant and/or the last new partner tested before sex. Risk factors for condom use at last sex and number of sexual partners included sexuality and education level. The multivariable models had good calibration but poor discrimination.ConclusionsIn this large sample with good representation across social and ethnic groups, we identified patient characteristics associated with higher risk of reinfection. Improved understanding of factors associated with reinfections and higher-risk sexual behaviours can aid development of interventions.Trial RegistrationISRCTN64390461.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251348693"},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of sleep problems and associated factors in older people living with HIV: A latent class analysis.","authors":"Aodi Zhang, Wen Cheng, Bolin Yang, Jibiao Chen, Hanlu Yin, Jing Gu, Zhuping Xu, Peng Xu, Xiaojun Meng","doi":"10.1177/09564624251349594","DOIUrl":"https://doi.org/10.1177/09564624251349594","url":null,"abstract":"<p><p>BackgroundTo identify sleep subtypes and associated factors in older people living with HIV (PLWH).MethodsA cross-sectional study was conducted to recruit older PLWH in Wuxi, China. Sleep quality was assessed using the Pittsburgh Sleep Quality Index. Latent class analysis was employed to examine sleep patterns, and logistic regression was performed to analyze associated factors.ResultsIn total, 830 participants were recruited with a median age of 60.9 years (IQR 55.4-67.9), of whom 79.0% were male, and 25.4% had sleep disorders. Three sleep patterns were identified: optimal sleep (48.3%), poor sleep (39.9%), and bad sleep (11.8%). Compared to the optimal sleep group, housing area (OR = 0.67, 95% CI: 0.50-0.91), social media app usage (OR = 0.57, 95% CI: 0.37-0.87), and years living with HIV (OR = 1.49, 95% CI: 1.05-2.10) were significantly associated with poor sleep. In contrast, age (OR = 1.89, 95% CI: 1.12-3.20), sex (OR = 1.94, 95% CI: 1.15-3.27), exercise frequency (OR = 1.64, 95% CI: 1.02-2.63), polypharmacy (OR = 0.27, 95% CI: 0.14-0.52), and years living with HIV (OR = 1.85, 95% CI: 1.11-3.07) were significantly associated with bad sleep.ConclusionsSignificant heterogeneities were observed across different sleep patterns among older PLWH. Potential associated factors should be considered when developing targeted strategies to improve sleep quality in this population.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251349594"},"PeriodicalIF":1.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the hidden epidemic: A scoping review of sexually transmitted diseases in Southeast Asia.","authors":"Nazri Che Dom, Rahmat Dapari, Mohamad Adzrin Harith Mohamad Syahriman, Adam Adha Mohd Sukri, Nur Leiza Azwa Kamarudin, Nur Shuhada Aqilah Ahmad Bakhtiar, Nur Syabila Alya Khairi, Nopadol Precha, Wan Shahriman Yushdie Wan Yusoff","doi":"10.1177/09564624251349598","DOIUrl":"https://doi.org/10.1177/09564624251349598","url":null,"abstract":"<p><p><b>Background:</b> Sexually transmitted diseases (STDs) pose a significant global health challenge, with Southeast Asia bearing a disproportionately high burden due to socio-demographic vulnerabilities, disparities in healthcare access, and prevailing cultural stigmas. Despite growing research interest in the region, a comprehensive synthesis of disease burden, risk factors, and intervention strategies remains limited.<b>Objectives:</b> This study aimed to systematically review research trends, study populations, and pathogen distributions of STDs in Southeast Asia to identify evidence gaps and inform future policy and intervention strategies.<b>Methods:</b> A systematic literature search was conducted using Scopus, Web of Science, and PubMed databases in accordance with PRISMA guidelines. Eligible studies were those focusing on STDs in Southeast Asia and included high-risk populations such as men who have sex with men (MSM), sex workers, youth, heterosexual men and women, transgender individuals, and people living with HIV (PLHIV). The review encompassed key STDs including HIV/AIDS, syphilis, gonorrhea, chlamydia, HPV, trichomoniasis, and hepatitis B & C.<b>Results:</b> From 2,867 records, 58 studies met the inclusion criteria. HIV/AIDS was the most frequently studied STD (80%), while bacterial STDs and transgender populations were significantly underrepresented. Most studies employed cross-sectional designs (60%), with few longitudinal or interventional studies. Geographically, research was concentrated in Malaysia, Thailand, and Singapore, with limited representation from Cambodia, Vietnam, and Indonesia.<b>Discussion:</b> The findings underscore substantial research gaps, particularly in bacterial STDs, studies involving heterosexual and transgender populations, and the application of intervention-based designs. Inconsistencies in reporting standards and population definitions further limit the comparability of findings across studies.<b>Conclusion:</b> This review highlights the need for more inclusive and methodologically diverse research on STDs in Southeast Asia. Future efforts should prioritize standardized data collection frameworks, improved surveillance systems, and greater emphasis on intervention studies to strengthen evidence-based public health responses in the region.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251349598"},"PeriodicalIF":1.4,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention and management strategies of anal squamous cell carcinoma among men who have sex with men living with HIV.","authors":"Zhi Wang, Xudong Zhao, Wenchao Du, Xiaoliang Zhang, Xingxing Li, Linquan Wang","doi":"10.1177/09564624251333035","DOIUrl":"10.1177/09564624251333035","url":null,"abstract":"<p><p>The incidence of anal squamous cell carcinoma (SCCA) has been rapidly increasing in recent years. The burden of the disease is expected to increase in the forthcoming years. Men who have sex with men living with HIV (MSMLWH) have a higher incidence of SCCA than the general population. The progression of SCCA usually develops from high risk human papillomavirus (HR-HPV) infection to high grade squamous intra-epithelial lesions (HSIL). HPV infection is highly prevalent in MSMLWH and is considered the most important risk factor for SCCA in MSMLWH. Although the prevalence worldwide is largely similar, the distribution of high-risk HPV genotypes varies. Education on sexuality and lifestyle, use of condoms, fixed sexual partner, effective antiretroviral therapy (ART), smoking cessation, and preventive male circumcision could reduce HPV infection in MSMLWH. Screening and treatment of HSIL have been widely applied to prevent SCCA, but divergence still exists in many studies. When treating HSIL, patients of different ages and risk factors need more consideration to develop standardized management strategies, especially for MSMLWH. Very few studies have examined the treatment of SCCA with MSMLWH. ART has dramatically changed the treatment of SCCA in MSMLWH. The safety and outcome of treatment are still primary concerns for MSMLWH. More studies in this field are necessary to develop treatment strategies for MSMLWH.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"533-541"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}