Heleen Vermandere, Santiago Aguilera-Mijares, Joaquín Escobar Trinidad, Diego Cerecero-García, Sergio Bautista-Arredondo
{"title":"Willingness to use pre-exposure prophylaxis among Mexican transgender women: A latent class analysis.","authors":"Heleen Vermandere, Santiago Aguilera-Mijares, Joaquín Escobar Trinidad, Diego Cerecero-García, Sergio Bautista-Arredondo","doi":"10.1177/09564624251367489","DOIUrl":"https://doi.org/10.1177/09564624251367489","url":null,"abstract":"<p><p>Background/ObjectivesTransgender women in Mexico face a high HIV prevalence, yet they remain insufficiently engaged in pre-exposure prophylaxis (PrEP). This study aimed to evaluate willingness to use HIV pre-exposure prophylaxis (PrEP) and its connection to risk behaviors among transgender women in Mexico.MethodsIn 2021, a cross-sectional study was conducted among Mexican transgender women to assess HIV risk factors and willingness to use PrEP. We used Latent Class Analysis to cluster participants with similar HIV risk behaviors, and multivariable logistic regression to identify covariates of willingness to use PrEP.ResultsAmong 266 transgender women, 40% were aware of PrEP, yet 78% reported willingness to use it after a brief introduction. Only 25% of the participants perceived themselves at high HIV risk. Through Latent Class Analysis, three classes were identified: 1) transactional sex with lower risk (10%); 2) no transactional sex with higher risk (25%); and 3) transactional sex with higher risk (65%), with reported willingness to use PrEP at 61%, 66% and 85%, respectively. In the multivariable model, belonging to class 3 (vs class 1) was associated with higher willingness to use PrEP (aOR:3.3; CI:1.2-9.5).ConclusionsWillingness to use PrEP aligned with HIV risk in those with a higher risk (class 3) and lower risk (class 1), but not in those at higher risk despite not reporting transactional sex (class 2). Therefore, not all who could benefit from PrEP may want it. Strategies are needed to promote PrEP's awareness and willingness to use considering the needs of transgender women subgroups.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251367489"},"PeriodicalIF":1.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond the application site: A case of imiquimod-induced cytokine-mediated systemic symptoms.","authors":"Sharang Gupta","doi":"10.1177/09564624251369416","DOIUrl":"https://doi.org/10.1177/09564624251369416","url":null,"abstract":"<p><p>Topical imiquimod is widely used for the treatment of external anogenital warts due to its potent immunomodulatory effects. Although local skin reactions are common, systemic side effects are rare and under-recognized. We describe the case of a 23-year-old male who developed recurrent, cytokine-mediated systemic symptoms-including fever, myalgias, and malaise-within hours of each application of imiquimod 5% cream to condylomata acuminata on the glans penis and inner prepuce. The lesions were located on non-keratinized, highly vascular mucosal surfaces, likely facilitating enhanced percutaneous absorption and systemic immune activation through Toll-like receptor 7 pathways. Symptoms resolved promptly with discontinuation of therapy and did not recur with alternative treatment using podophyllin resin. This case underscores the importance of recognizing systemic adverse reactions to topical immunotherapies, particularly when applied to mucosal surfaces, and highlights the need for appropriate patient counseling and individualized treatment approaches.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251369416"},"PeriodicalIF":1.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas Kyalo Muendo, Peninah K Masibo, George Muhua
{"title":"Determinants of HIV self-testing utilization among health sciences undergraduate students in Kenya.","authors":"Nicholas Kyalo Muendo, Peninah K Masibo, George Muhua","doi":"10.1177/09564624251367490","DOIUrl":"https://doi.org/10.1177/09564624251367490","url":null,"abstract":"<p><p>BackgroundHIV self-testing (HIVST) was endorsed by WHO in 2016 to expand access to HIV diagnosis, especially for young people. Kenyan youths, including university students, remain vulnerable to HIV, yet uptake of free HIVST kits is inconsistent. This study assessed determinants of HIVST utilization among health sciences undergraduates at the University of Nairobi.MethodsWe conducted a cross-sectional analytical study at the Chiromo and Faculty of Health Sciences campuses. Multi-stage cluster sampling yielded 412 students from Medicine, Pharmacy, Nursing, Dentistry and Medical Laboratory Science. Data on socio-demographics, sexual behaviour, stigma, and institutional access were collected via self-administered questionnaires and analysed in R. Associations were examined using χ<sup>2</sup>/Fisher's exact tests and Wilcoxon tests; variables with <i>p</i> < .05 entered a multivariable mixed-effects logistic regression model to account for clustering by course and year of study.ResultsOverall, 30.5% reported prior HIVST use. Uptake was higher among older students and those in advanced years. Being in a relationship and consistently using condoms were associated with lower HIVST uptake. Recency of the last HIV test strongly predicted use, with students tested within the preceding 3-6 months more likely to self-test. Residence and gender were not independent predictors after adjustment.ConclusionsHIVST uptake among Kenyan health sciences undergraduates is moderate but uneven. Age, academic seniority and recent HIV testing history increase uptake, whereas perceived low risk (e.g. condom use) reduces it. Universities and the Ministry of Health should pair easy kit access with messaging that encourages routine testing regardless of perceived risk to accelerate progress toward UNAIDS 95-95-95 targets.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251367490"},"PeriodicalIF":1.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Earl Francis Infante Mallari, Karl Peltzer, Mein-Woei Suen, Lyndon Esconde Santos, Yasmine A Gunawan
{"title":"Prevalence and factors associated with HIV sexual risk behavior among Filipino youth: Analysis of nationally representative data.","authors":"Earl Francis Infante Mallari, Karl Peltzer, Mein-Woei Suen, Lyndon Esconde Santos, Yasmine A Gunawan","doi":"10.1177/09564624251364345","DOIUrl":"https://doi.org/10.1177/09564624251364345","url":null,"abstract":"<p><p>BackgroundFilipino adolescents and young adults are at higher risk for acquiring human immunodeficiency virus (HIV) than any other age groups; 46% of new HIV infections in 2022 were in people aged 15 - 24 years. However, little is known about the prevalence and associated factors of HIV sexual risk behavior (SRB) among this vulnerable population in the Philippines.MethodsThis is a secondary analysis of a cross-sectional study from the 2021 Young Adult Fertility and Sexuality Study (YAFS5). 3120 sexually experienced Filipinos aged 15 - 24 were included in the analysis. Binary logistic regression and Poisson regression were used to test the relationship between the proposed independent variables and HIV SRB.ResultsApproximately two-thirds (<i>n</i> = 2101, 65.5%) of Filipino youth engage in HIV SRB, and this is significantly higher among males (<i>n</i> = 1212, 74.9%, <i>p</i> < .001). Factors associated with HIV SRB include ever married/cohabited (AOR: 0.25, 95% CI: 0.20 - 0.32), have had sex with a virtual partner (AOR: 2.44, 95% CI: 1.25 - 4.78), currently smoking (AOR: 1.35, 95% CI: 1.04 - 1.76), lifetime drug use (AOR: 4.30, 95% CI: 2.15, 8.59), and suicidal ideation (AOR: 1.51, 95% CI: 1.17, 1.96). Differences between males and females were also noted.ConclusionsThis study highlights the vulnerabilities and co-occurring health risk behaviors among young Filipinos that may increase their risk of HIV transmission. Findings underscore the need for integrated, youth-focused programs-such as comprehensive sexual and reproductive education and improved service access-while acknowledging sociocultural challenges in a deeply religious context.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251364345"},"PeriodicalIF":1.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jorge Ligero-López, Antonio Beltrán-Rosel, María Ducóns-Márquez, Daniel Escribano-Pardo, Jose Luis Juan-Bañón, Beatriz López-Alonso
{"title":"<i>Streptococcus urinalis:</i> A potential case of male urethritis caused by a novel pathogen.","authors":"Jorge Ligero-López, Antonio Beltrán-Rosel, María Ducóns-Márquez, Daniel Escribano-Pardo, Jose Luis Juan-Bañón, Beatriz López-Alonso","doi":"10.1177/09564624251365133","DOIUrl":"https://doi.org/10.1177/09564624251365133","url":null,"abstract":"<p><p>Urethritis is a frequent lower urinary tract infection often linked to sexually transmitted infections (STIs). While <i>Neisseria gonorrhoeae</i> and <i>Chlamydia trachomatis</i> are the main pathogens, other microorganisms such as <i>Mycoplasma genitalium</i>, <i>Trichomonas vaginalis</i>, and <i>Ureaplasma urealyticum</i> may also be involved. In over half of non-gonococcal urethritis (NGU) cases, no causative agent is identified. We present the case of a 37-year-old man with scrotal pain, painful ejaculation, dysuria, and urethral discharge following a single unprotected sexual encounter. Initial STI PCR was positive for <i>Ureaplasma urealyticum</i>, and azithromycin was prescribed. Symptoms persisted, and a urethral culture revealed <i>Streptococcus urinalis</i>, confirmed by MALDI-TOF MS and 16S rRNA sequencing. Gram staining showed numerous leukocytes and Gram-positive cocci in chains. A second urethral swab yielded the same organism. The isolate was fully susceptible to all tested antibiotics. Although <i>S. urinalis</i> has been described in urinary tract infections and sepsis, to our knowledge, this is the first reported case suggesting a possible role in male urethritis. While prostatitis or epididymitis cannot be ruled out, the repeated isolation of <i>S. urinalis</i> and persistent symptoms support its potential pathogenicity. This case adds to growing evidence implicating <i>S. urinalis</i> in genitourinary tract infections.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251365133"},"PeriodicalIF":1.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pierre Kassis, Joe Lebbos, Nabil Chehata, Gebrael Saliba, Elie Haddad, Jacques Choucair, Akel Azzi
{"title":"Shifting priorities: U.S. health policy and the fragile future of global HIV/AIDS efforts.","authors":"Pierre Kassis, Joe Lebbos, Nabil Chehata, Gebrael Saliba, Elie Haddad, Jacques Choucair, Akel Azzi","doi":"10.1177/09564624251365146","DOIUrl":"https://doi.org/10.1177/09564624251365146","url":null,"abstract":"<p><p>ObjectiveThis narrative review examines the impact of the United States on the war against HIV/AIDS and thus the impact of political ideologies on the financing of the medical sector.DiscussionInitially marked by stigma, particularly in the early years of the epidemic, the US response was transformed with the launch of the Presidential Emergency Plan for AIDS Relief (PEPFAR) in 2003. PEPFAR has partnered with entities such as the Global Fund and the Joint United Nations Programme on HIV/AIDS (UNAIDS), retranslating global health governance. Despite this success, the global response remains dependent on the support of the United States. Political changes under the leadership of the conservatives have limited funding. Therefore, political polarization in the US is undermining long-term progress on HIV/AIDS prevention and treatment, particularly in low- and middle-income countries.ConclusionBy tracing historical developments and analysing current funding trends, the article highlights the urgent need for sustainable and depoliticized investments in global health systems. Without renewed bipartisan commitment and greater local ownership, the vision of eliminating AIDS as a public health threat by 2030 is seriously threatened.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251365146"},"PeriodicalIF":1.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness of dolutegravir based antiretroviral treatment in preventing vertical transmission of HIV in West Bengal, India: A retrospective cohort study.","authors":"Suman Ganguly, Debjit Chakraborty, Falguni Debnath, Sombuddha Biswas, Mihir Bhatta, Agniva Majumdar, Alok Kumar Deb","doi":"10.1177/09564624251361183","DOIUrl":"https://doi.org/10.1177/09564624251361183","url":null,"abstract":"<p><p>BackgroundSeveral antiretroviral regimens have been used for prevention of mother to child transmission (MTCT) of HIV, with maternal dolutegravir-based regimens (e.g. tenofovir/lamivudine/dolutegravir - TLD) being the latest, initiated in last 3-4 years. There is a need for assessment of effectiveness of this new regimen as compared to earlier efavirenz-based (tenofovir/lamivudine/efavirenz - TLE) and other regimens in program settings.MethodWe conducted this retrospective cohort study to determine effectiveness of the TLD regimen in preventing antenatal, intranatal and postnatal MTCT compared to earlier regimens. 1905 HIV-exposed infants in West Bengal, India from April 2017 to March 2023 with available polymerase chain reaction for HIV at 314 Integrated Counselling and Testing Centres were considered. Duration of antenatal antiretroviral treatment and infant feeding practices types were also analyzed.ResultsAmong all mothers, 666 (35%) received TLD and 1194 (63%) TLE. With TLD, MTCT rate was significantly lower (2% vs 6.5%) [Adjusted Odds Ratio (AOR) = 0.28; 0.15-0.52] than all other regimens. Duration of maternal antiretroviral therapy (weeks) (AOR = 0.96; 0.95-0.98) and infant feeding practices (AOR = 0.09; 0.03-0.25) showed significant association with reduced MTCT rate.ConclusionDolutegravir-based ART is more effective than earlier regimens and promises to achieve the elimination of pediatric HIV.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"9564624251361183"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Symmetrical drug-related intertriginous flexural exanthema following syphilis treatment with benzathine benzylpenicillin.","authors":"Darshanie Nayanakanthi Mallikarachchi, Amy Bennett, Bogusia Kasternow","doi":"10.1177/09564624251347110","DOIUrl":"10.1177/09564624251347110","url":null,"abstract":"<p><p>Symmetrical drug-related intertriginous flexural exanthema (SDRIFE), formerly known as 'Baboon Syndrome', is a rare benign allergic reaction, often triggered by systemic drugs. This case report presents a 37-year-old woman with syphilis who developed SDRIFE following benzathine benzylpenicillin treatment. This is the first published case of SDRIFE during syphilis treatment and emphasizes the importance of early recognition and specialist input to ensure safe and effective treatment continuation.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"738-740"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julio C Muñiz-Salgado, Regina B Hurtado-Arroyo, Santa García-Cisneros, María Olamendi-Portugal, Miguel Angel Sánchez-Aleman, Dayana Nicté Vergara-Ortega, Antonia Herrera-Ortiz
{"title":"Prevalence of <i>Chlamydia trachomatis</i> and associated factors in pregnant adolescent and young adult females from Morelos, Mexico: A cross-sectional study.","authors":"Julio C Muñiz-Salgado, Regina B Hurtado-Arroyo, Santa García-Cisneros, María Olamendi-Portugal, Miguel Angel Sánchez-Aleman, Dayana Nicté Vergara-Ortega, Antonia Herrera-Ortiz","doi":"10.1177/09564624251344436","DOIUrl":"10.1177/09564624251344436","url":null,"abstract":"<p><p>Background<i>Chlamydia trachomati</i>s (<i>Ct</i>) is considered the most common bacterial sexually transmitted infection worldwide, adolescent and young adult female are at high risk of contracting this infection. The aim of this study was to evaluate the prevalence of <i>Ct</i> and associated factors in pregnant adolescents and young adults (PAYA).MethodsThis cross-sectional study was conducted between 2018 and 2020 with Mexican PAYA famales aged 12-24 years, who attended health services for pregnancy care. <i>Ct</i> was detected by PCR of the <i>omp1</i> gene. The prevalence of <i>Ct</i> was reported with a 95% confidence interval. Factors associated with <i>Ct</i> prevalence were identified by multivariate logistic regression analysis.ResultsThe prevalence of <i>Ct</i> was 12.9% (95% CI: 9-15) and 18.5% of them had coinfection with HSV-2 (aOR 3.1; 95% CI: 1.49-6.42). Frequent alcohol consumption (aOR 2.3, 95% CI:1.07-5.08), antibiotic use in the last year (aOR 1.9, 95% CI:1.06-3.39), ≥3 lifetime sexual partners (aOR 0.5, 95% CI:0.24-0.98) and hormonal contraceptive use (aOR 2.2, 95% CI:1.08-4.34) were associated with <i>Ct</i>.ConclusionThe prevalence of <i>Ct</i> in PAYA is high. Screening should be performed in symptomatic and asymptomatic pregnant females to reduce the risk of vertical transmission and the risk of pelvic inflammatory disease and infertility.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"705-711"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefano Veraldi, Stefano Ramoni, Italo Francesco Aromolo, Gianluca Nazzaro
{"title":"Ten cases of erythematous-petechial lesions of the palate caused by fellatio, and a review of the literature.","authors":"Stefano Veraldi, Stefano Ramoni, Italo Francesco Aromolo, Gianluca Nazzaro","doi":"10.1177/09564624251347474","DOIUrl":"10.1177/09564624251347474","url":null,"abstract":"<p><p>Erythematous-petechial lesions of the palate caused by fellatio are probably frequent. However, they have rarely been reported in the literature because they are not easily visible by the patient, are almost always asymptomatic and heal spontaneously within a few days. We report 10 patients (9 females and 1 male, with an age ranging from 29 to 59 years) with this condition. Two patients complained of mild burning sensation in the oral cavity. In all patients it was possible to exclude sexually transmitted infections. No treatment was prescribed. Complete remission was observed within 2 weeks.</p>","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"741-743"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}