International Journal of STD & AIDS最新文献_第7页

Developing and validating a clinical risk score to predict losses in the PISCIS cohort of people with HIV. 开发并验证临床风险评分，以预测 PISCIS 艾滋病毒感染者队列中的损失。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-10-01 Epub Date: 2024-08-15 DOI: 10.1177/09564624241270967

Jorge Palacio-Vieira, Yesika Díaz, Sergio Moreno-Fornés, Andreu Bruguera, Daniel K Nomah, Josep M Llibre, Hernando Knobel, Iván Chivite, José M Miró, Paula Suanzes, Francisco Fanjul, Gemma Navarro, Lizza Macorigh, Francesc Homar Borràs, Ingrid Vilaró López, Amat Joaquim Orti Llaveria, Jordi Casabona, Arkaitz Imaz, Juliana Reyes-Urueña

{"title":"Developing and validating a clinical risk score to predict losses in the PISCIS cohort of people with HIV.","authors":"Jorge Palacio-Vieira, Yesika Díaz, Sergio Moreno-Fornés, Andreu Bruguera, Daniel K Nomah, Josep M Llibre, Hernando Knobel, Iván Chivite, José M Miró, Paula Suanzes, Francisco Fanjul, Gemma Navarro, Lizza Macorigh, Francesc Homar Borràs, Ingrid Vilaró López, Amat Joaquim Orti Llaveria, Jordi Casabona, Arkaitz Imaz, Juliana Reyes-Urueña","doi":"10.1177/09564624241270967","DOIUrl":"10.1177/09564624241270967","url":null,"abstract":"Background: People lost to follow-up (LTFU) from HIV care have an increased risk of worse health. The objective of this study is to create and validate a risk score to predict LTFU among PLWH in Catalonia and the Balearic Islands.Methods: 6661 PLWH were included. LTFU were those without contact with HIV care for 12 months or more. Logistic regression models were used to assess the role of independent factors on LTFU. The validation included a 10-fold iteration to predict the performance of the regression model and the Area under the ROC Curve (AUC). Regression coefficients were rounded and summed to construct the score.Results: Determinants of LTFU included being younger than 34 years (OR: 1.80, CI, 1.44-2.23), not having been born in Spain (OR: 1.32, 1.11-1.58), men who inject drugs (OR: 2.10, 1.38-3.19), having a detectable viral load (OR: 3.14, 2.47-3.99), and ≤2.5 years since HIV diagnosis (OR: 3.84, 3.10-4.75). The validation of determinants resulted in a mean AUC of 0.69 and the risk-score revealed that 28.8% had a medium and 3.4% a high risk of LTFU respectively.Conclusions: Findings can be used to prevent LTFU in HIV care.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"952-962"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case-control study on challenges in loss of follow-up care and the limitations in the reach of HIV policies for women. 关于失去后续护理的挑战和妇女艾滋病毒政策覆盖范围局限性的病例对照研究。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-10-01 Epub Date: 2024-07-21 DOI: 10.1177/09564624241263614

Gabriela Tizianel Aguilar, Guilherme Lamperti Thomazi, Lisiane Acosta, Andrei Fernandes da Rocha, Maria Leticia Rodrigues Ikeda

{"title":"Case-control study on challenges in loss of follow-up care and the limitations in the reach of HIV policies for women.","authors":"Gabriela Tizianel Aguilar, Guilherme Lamperti Thomazi, Lisiane Acosta, Andrei Fernandes da Rocha, Maria Leticia Rodrigues Ikeda","doi":"10.1177/09564624241263614","DOIUrl":"10.1177/09564624241263614","url":null,"abstract":"Introduction: HIV has transitioned from a devastating 1980s epidemic to a manageable chronic condition with antiretroviral therapy. In Brazil, challenges persist, including high detection rates and loss of medical follow-up among people living with HIV/AIDS (PLHIV). Adherence, engagement, and avoiding loss to follow-up are critical for effective HIV/AIDS prevention and care.Objectives: This case-control study within longitudinal research on PLHIV linkage and retention in Porto Alegre aims to analyze factors associated with treatment abandonment.Methods: The study, based on patients from the Therapeutic Care Service for HIV and AIDS at Sanatorio Partenon Hospital, involved 360 PLHIV in a retention and linkage outpatient clinic.Results: Risk factors for loss to follow-up include cisgender women, diagnosis between 1991 and 2005, and non-adherence to antiretroviral treatment (ART). Conversely, cisgender men, diagnosis between 2015 and 2023, and good ART adherence were protective factors.Conclusion: Gender disparities and ART non-adherence pose significant challenges in comprehensive PLHIV care. Cisgender women diagnosed before 2005 face higher risk, while cisgender men diagnosed after 2015 with good ART adherence are more protected, influencing care and prevention strategies for PLHIV.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"894-901"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of rapid-antiretroviral therapy in a cohort of treatment-naïve migrants living with HIV in a high income setting. 快速抗逆转录病毒疗法对高收入环境中一批治疗无效的艾滋病病毒感染者的影响。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-10-01 Epub Date: 2024-08-06 DOI: 10.1177/09564624241270970

Sasha Trevisan, Giuseppe Gasparro, Seble Tekle Kiros, Marco Pozzi, Costanza Malcontenti, Irene Campolmi, Riccardo Paggi, Annalisa Cavallo, Alberto Farese, Filippo Ducci, Massimo Meli, Mario Pittorru, Alessandro Bartoloni, Gaetana Sterrantino, Filippo Lagi

{"title":"Impact of rapid-antiretroviral therapy in a cohort of treatment-naïve migrants living with HIV in a high income setting.","authors":"Sasha Trevisan, Giuseppe Gasparro, Seble Tekle Kiros, Marco Pozzi, Costanza Malcontenti, Irene Campolmi, Riccardo Paggi, Annalisa Cavallo, Alberto Farese, Filippo Ducci, Massimo Meli, Mario Pittorru, Alessandro Bartoloni, Gaetana Sterrantino, Filippo Lagi","doi":"10.1177/09564624241270970","DOIUrl":"10.1177/09564624241270970","url":null,"abstract":"Background: We evaluated the effect of rapid ART (RA) compared to delayed ART (DA) on viral load suppression (viral load <50 cp/mL) and loss to follow-up (LTFU) in a cohort of migrants living with HIV (MLWHs) in Italy.Methods: Data were retrospectively gathered from MLWHs who began care at the Infectious and Tropical Diseases Unit of the Careggi University Hospital from January 2014 to December 2022. RA was defined as antiretrovirals prescribed within 7 days of HIV diagnosis. The study ended on April 30, 2023, or upon patient LTFU. Chi-square and non-parametric tests assessed differences in categorical and continuous variables, respectively. Kaplan-Meyer survival analysis was performed to estimate the probability of loss to follow-up. Cox regression analysis was performed to evaluate factors associated with a loss to follow-up.Results: 87 MLWHs were enrolled: 20 (23%) on RA and 67 (77%) on DA. In the RA group there were more PLWH with a previous AIDS event (p < .001) however, there was no significant difference in the LTFU rates between the groups (aHR 0.6, 95%CI 0.1-3.1; p = .560; Logrank = 0.2823). Being an out-of-status MLWH was the only predictor of LTFU. By 6 months, virological suppression was achieved in 61.2% (n = 41) in DA and 70.0% in the RA group (n = 14) (Logrank p = .6747).Conclusions: RA did not significantly affect LTFU rates or the achievement of viral load suppression. The study suggests that further research is needed to assess the impact of RA in high income settings.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"858-864"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in HIV incidence and mortality across Bharat (India) after the emergence of COVID-19. COVID-19 出现后印度巴拉特地区的艾滋病毒发病率和死亡率趋势。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-10-01 Epub Date: 2024-08-06 DOI: 10.1177/09564624241271945

Karan Varshney, Ashmit D Mustafa

{"title":"Trends in HIV incidence and mortality across Bharat (India) after the emergence of COVID-19.","authors":"Karan Varshney, Ashmit D Mustafa","doi":"10.1177/09564624241271945","DOIUrl":"10.1177/09564624241271945","url":null,"abstract":"Background: Human immunodeficiency virus (HIV) is a sexually transmitted infection impacting populations worldwide. While there have been major improvements in controlling HIV over recent years, the COVID-19 pandemic may have potentially resulted in major interruptions to this control of HIV. Bharat (India) is a country that has been greatly impacted by the COVID-19 pandemic, and we aimed to analyse the trends in HIV control since the start of the pandemic.Methods: In this study we evaluated changes in rates of HIV incidence and mortality across Bharat for the years both before, and after, the start of the COVID-19 pandemic. Percent and absolute changes were determined, and thereafter, both bivariate and multi linear regression was conducted to evaluate the relationship between COVID-19 burden and changes in HIV epidemiology across the nation.Results: It was shown that, despite the COVID-19 pandemic, annual incidence and deaths of HIV/AIDS have both decreased across Bharat. From 2019-2021, in Bharat, the total number of new HIV cases annually decreased by 9.03%, and the total number of HIV/AIDS deaths annually decreased by 28.82%. A similar trend was shown across most states/union territories; however, there were notable exceptions (such as Karnataka, Bihar, and Assam) where the rates have instead increased.Conclusions: Our analysis has demonstrated that government efforts to control the HIV/AIDS epidemic have not been greatly impacted across the majority of Bharat since the emergence of COVID-19. The reduction in annual HIV/AIDS deaths in the country has been better than the world average, and the improvements from the period of 2019 to 2021 were greater than those from 2017 to 2019. Regardless, there are regions in the nation where the epidemic has instead worsened during this period.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"865-872"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transactional sex and risky sexual practices in Jamaica. 牙买加的性交易和危险性行为。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI: 10.1177/09564624241267333

Christina G Silvera, Sharlene Jarrett, Nicola Skyers

{"title":"Transactional sex and risky sexual practices in Jamaica.","authors":"Christina G Silvera, Sharlene Jarrett, Nicola Skyers","doi":"10.1177/09564624241267333","DOIUrl":"10.1177/09564624241267333","url":null,"abstract":"Background: Transactional sex relationships (TSRs) create financial and emotional support for men and women, as well as an increased sexual risk. Studies have reported high HIV and STI transmission rates among young women in transactional sex relationships. However, little is known about TSR prevalence in Jamaica and risky sexual practices among participants. This study investigates the sexual behaviour of Jamaicans in TSR.Methods: Secondary data analysis of a national survey revealed that 586 participants (38%) self-reported being in at least one TSR in the last 12 months. We also identified a third category called \"Benefluids\", who play both roles of benefactor and beneficiary in transactional sex relationships.Results: 59 percent of male Benefluids had two to five transactional sex relationship partners in the last 12 months, compared to 40% of female Benefluids. Twenty-eight percent of female Benefluids reported sexually transmitted infection symptoms in the last 12 months compared to 13.5% of male Benefluids. While females reported more sexually transmitted infection symptoms, young men had the highest sexual risk precursors.Conclusions: People in transactional sex relationships often play the role of beneficiaries and benefactors to meet material and sexual needs but this increases the risk of STI symptoms.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"850-857"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mobility and sexually transmitted infections: Exploring intersectional axes of alcohol consumption and risky sexual behavior among Indian men. 流动性与性传播感染：探索印度男性饮酒和危险性行为的交叉轴。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-10-01 Epub Date: 2024-08-13 DOI: 10.1177/09564624241273033

Pintu Paul, Rakesh Chandra

{"title":"Mobility and sexually transmitted infections: Exploring intersectional axes of alcohol consumption and risky sexual behavior among Indian men.","authors":"Pintu Paul, Rakesh Chandra","doi":"10.1177/09564624241273033","DOIUrl":"10.1177/09564624241273033","url":null,"abstract":"Objective: Studies in India and other low-income countries find an inconsistent association between mobility/migration and sexually transmitted infections (STIs) among men. This study comprehensively examined the association between mobility and STIs among men in India. It also assessed heterogeneous associations of mobility, alcohol consumption, and risky sexual behavior with STIs using interaction analysis.Methods: We utilized a sample of 71,128 sexually active men aged 15-54 years from the 2019-21 National Family Health Survey-5. Binary logistic regression models were employed to study the associations.Results: Among the study participants, 16% were mobile and away from home for a month or more in the last 12 months. Around 29% of men reported alcohol consumption and 6% had risky sexual behavior (sexual intercourse with a non-marital/non-cohabitating partner). Regression results suggest that mobility (AOR: 1.41, 95% CI: 1.29-1.55 [short-duration]; AOR: 1.95, 95% CI: 1.77-2.13 [long-duration]) and alcohol consumption (AOR: 1.32, 95% CI: 1.24-1.40) were significantly associated with an increased risk of STIs, even after controlling for socio-demographic covariates. Interaction analysis further reveals that mobile men who consumed alcohol and engaged in risky sexual behavior had a significantly higher likelihood of contracting an STI-twice as high in cases of short-duration mobility and three times higher in cases of long-duration mobility.Conclusion: Our study indicates that both short and long-duration mobility are significantly associated with an increased risk of STIs among men. Alcohol consumption and risky sexual behavior further exacerbate the risk of STIs in mobile men. Initiatives for STI/HIV prevention among men must pay particular attention to temporary mobile men for both short and long durations.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"924-934"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mortality of cytomegalovirus infection among people living with HIV: A retrospective study from a tertiary hospital in Indonesia. 艾滋病病毒感染者感染巨细胞病毒的死亡率：印度尼西亚一家三级医院的回顾性研究。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1177/09564624241273848

Evy Yunihastuti, Nia Kurniati, Muhammad Yusuf, Andi Yasmon, Fithriyah Sjatha, Lukman Edwar, Saskia Aziza Nusyirwan, Darma Imran, Juferdy Kurniawan, Anna Mira Lubis, Mira Yulianti, Ceva Wicaksono Pitoyo, Pringgodigdo Nugroho, Lusiani Rusdi, Adityo Susilo, Robert Sinto, Dina Muktiarti, Kartika Maharani, Amalia Irsha Adhari, Rina La Distia Nora, Yustika Novianti Achmad, Markus Molan Purap, Teguh Harjono Karjadi, Alvina Widhani

{"title":"Mortality of cytomegalovirus infection among people living with HIV: A retrospective study from a tertiary hospital in Indonesia.","authors":"Evy Yunihastuti, Nia Kurniati, Muhammad Yusuf, Andi Yasmon, Fithriyah Sjatha, Lukman Edwar, Saskia Aziza Nusyirwan, Darma Imran, Juferdy Kurniawan, Anna Mira Lubis, Mira Yulianti, Ceva Wicaksono Pitoyo, Pringgodigdo Nugroho, Lusiani Rusdi, Adityo Susilo, Robert Sinto, Dina Muktiarti, Kartika Maharani, Amalia Irsha Adhari, Rina La Distia Nora, Yustika Novianti Achmad, Markus Molan Purap, Teguh Harjono Karjadi, Alvina Widhani","doi":"10.1177/09564624241273848","DOIUrl":"10.1177/09564624241273848","url":null,"abstract":"Background: There are still many patients newly diagnosed with HIV at an advanced stage in Indonesia. We aimed to identify factors associated with 1-year mortality among cytomegalovirus (CMV)-infected people living with HIV (PLHIV).Methods: This retrospective cohort study was carried out at a tertiary-care hospital in Jakarta, Indonesia (January 2017 to December 2022). We included PLHIV with CMV end-organ disease (EOD) and CMV syndrome. The presence of CMV infection was confirmed by fulfilling one of the following criteria: (1) positive PCR from plasma, urine, cerebrospinal fluid, or other body fluids, or associated tissue for CMV EOD; (2) positive immunoglobulin M (IgM); or (3) consistent symptoms and signs of CMV retinitis.Results: Out of 1737 PLHIV, 147 (8.5%, 95% CI: 7.2 to 9.9%) were diagnosed with CMV infection. Forty (27.2%, 95% CI: 20.6 to 35.1%) patients died within 1 year of being diagnosed. Only anti-retroviral therapy (ART) defaulting (aHR 3.31, 95% CI: 1.12 to 9.73) was found to be significantly associated with 1-year mortality in multivariate analysis.Conclusion: Defaulted ART status is significantly associated with reduced 1-year survival after CMV infection diagnosis. Patients with low CD4 counts, especially those with <50 cells/μL, should be assessed for CMV infection, monitored, and treated accordingly.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"982-989"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV and intersectional stigma among people living with HIV and healthcare workers and antiretroviral therapy adherence in the Dominican Republic. 多米尼加共和国艾滋病毒感染者和医护人员对艾滋病毒和交叉性污名以及坚持抗逆转录病毒疗法的情况。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-10-01 Epub Date: 2024-07-22 DOI: 10.1177/09564624241259801

Jelani Kerr, Ibrahim Yigit, Dustin M Long, Robert Paulino-Ramírez, John Waters, Jiaying Hao, Laura Nyblade, Nelson Varas-Díaz, Sylvie Naar, Christyenne L Bond, Henna Budhwani, Janet M Turan

{"title":"HIV and intersectional stigma among people living with HIV and healthcare workers and antiretroviral therapy adherence in the Dominican Republic.","authors":"Jelani Kerr, Ibrahim Yigit, Dustin M Long, Robert Paulino-Ramírez, John Waters, Jiaying Hao, Laura Nyblade, Nelson Varas-Díaz, Sylvie Naar, Christyenne L Bond, Henna Budhwani, Janet M Turan","doi":"10.1177/09564624241259801","DOIUrl":"10.1177/09564624241259801","url":null,"abstract":"Background: HIV-related stigma, discrimination, and social marginalization undermines optimal HIV care outcomes. More research examining the impact of HIV-related stigma, discrimination, other interlocking forms of oppression, and antiretroviral therapy (ART) adherence is needed to optimize HIV treatment programming. This study uses data from two clinics in the Dominican Republic to examine client and healthcare worker (HCW) perceptions of HIV and intersectional stigmas among people living with HIV.Methods: Surveys exploring demographics, HIV-related stigma, various dimensions of discrimination (race/ethnicity, HIV status, sexual orientation), healthcare engagement, and medication adherence were collected from 148 clients and 131 HCWs. Analysis of variance was conducted to examine differences in stigma by clinic and logistic regressions were used to determine predictors of optimal client medication adherence.Results: Perceived discrimination in healthcare facilities due to clients' sexual orientation retained significance in crude and multivariable logistic regression models and was negatively associated with ART adherence (aOR:0.79; 95% CI:0.66, 0.95).Discussion: Findings highlight the importance of implementing strategies to address stigma, discrimination, and social marginalization, particularly within healthcare facilities.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"840-849"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11471043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing and improving the quality of guideline-adherent hepatitis B virus care in people with HIV: A cross-sectional study. 评估和提高HIV感染者遵循指南的乙型肝炎病毒护理质量：一项横断面研究。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-10-01 Epub Date: 2023-09-20 DOI: 10.1177/09564624231203735

Patrick Ga Oomen, Vincent Jp van Kraaij, Anna M Gerritsma, Frans M Verduyn Lunel, Greet J Boland, Andy Im Hoepelman, Berend J van Welzen

{"title":"Assessing and improving the quality of guideline-adherent hepatitis B virus care in people with HIV: A cross-sectional study.","authors":"Patrick Ga Oomen, Vincent Jp van Kraaij, Anna M Gerritsma, Frans M Verduyn Lunel, Greet J Boland, Andy Im Hoepelman, Berend J van Welzen","doi":"10.1177/09564624231203735","DOIUrl":"10.1177/09564624231203735","url":null,"abstract":"The increasing use of non-tenofovir containing antiretroviral regimens calls for renewed attention to the prevention and management of hepatitis B virus (HBV) in people with HIV (PWH). We retrospectively assessed adherence to HBV guidelines, including complete HBV screening in PWH. In people with HIV/HBV co-infection, this included HBV therapy, screening for hepatitis delta virus (HDV) and on-therapy virologic response monitoring. HIV/HBV co-infection in PWH was defined as the presence of hepatitis B surface antigen (HBsAg) at the last measurement before study entry or detectable HBV-DNA for ≥6 months. After assessment, missing laboratory tests were performed to optimize HBV monitoring and screening for co-infections. Of all PWH under follow-up, 1484/1633 (90.9%) were adequately screened for HBV. After performing missing screening tests, 466 of 1618 PWH with complete screening results (28.8%) were non-immune for HBV infection. Fifty-one (3.2%) with HIV/HBV co-infection were identified. HBV treatment was adequate in 51/51 (100%). Screening for hepatitis A, C and delta virus antibodies and fibrosis was performed in 51/51 (100%), 49/51 (96.1%), 17/51 (35.3%) and 38/51 (74.5%). Annual HBV-DNA or HBsAg monitoring was done in 18/51 (35.3%) and hepatocellular carcinoma (HCC) surveillance in 2/9 (22.2%) of those indicated. Additional testing in those with missing data identified 4/34 (11.8%) persons with HDV antibodies and 3/30 (10%) with HBsAg seroclearance. Our study demonstrates the feasibility and added value of evaluating HBV care components and performing missing laboratory tests, identifying a large number of HBV vaccination candidates and HDV antibody screening, HBsAg monitoring and HCC surveillance as key areas for improvement.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"910-915"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41122067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neisseria gonorrhoeae isolates resistant to extended spectrum cephalosporins and macrolides isolated from symptomatic men in western Kenya. 从肯尼亚西部有症状的男性中分离出的对广谱头孢菌素和大环内酯类药物耐药的淋病奈瑟菌。

IF 1.4 4区医学

International Journal of STD & AIDS Pub Date : 2024-10-01 Epub Date: 2024-08-14 DOI: 10.1177/09564624241273774

Walter Agingu, Fredrick Otieno, Ezekiel Dibondo, Patriciah Wambua, Adriana Le Van, Ann Jerse, Eric Garges, Supriya D Mehta

{"title":"Neisseria gonorrhoeae isolates resistant to extended spectrum cephalosporins and macrolides isolated from symptomatic men in western Kenya.","authors":"Walter Agingu, Fredrick Otieno, Ezekiel Dibondo, Patriciah Wambua, Adriana Le Van, Ann Jerse, Eric Garges, Supriya D Mehta","doi":"10.1177/09564624241273774","DOIUrl":"10.1177/09564624241273774","url":null,"abstract":"Background: We characterized the antimicrobial resistance (AMR) profiles of Neisseria gonorrhoeae (NG) isolated from symptomatic men at a sexually transmitted infection clinic in Kisumu, Kenya.Methods: Two urethral swabs were obtained from symptomatic men between 2020 and 2022, one for Gram's stain and the other inoculated directly onto modified Thayer-Martin media containing 1% VCNT and 1% IsoVitaleX enrichment. Culture results were confirmed by colony morphology, Gram's stain and oxidase test. Duplicate isolates were shipped to Uniformed Services University for confirmation and characterization. Susceptibility to eight drugs was assessed by E-test. Agar dilution confirmed resistance to ceftriaxone, cefixime, and azithromycin. Susceptibility, intermediate resistance (IR), and resistance (R) were determined according to published criteria.Results: Of 154 enrolled participants, 112 were culture-positive for NG. Agar dilution results in 110 (98.2%) showed the following: azithromycin-R (1.8%), and 4.5% R or IR to ceftriaxone or cefixime: ceftriaxone-R (0.9%), ceftriaxone-IR (2.7%), and cefixime-IR (2.7%). By E-test, most isolates were IR or R to tetracycline (97.2%), penicillin (90.9%), and ciprofloxacin (95.4%).Conclusions: We detected NG with resistance to azithromycin and ceftriaxone, indicating a growing threat to the current Kenyan dual syndromic treatment of urethritis with cephalosporin plus macrolides. Ongoing AMR surveillance is essential for effective drug choices.","PeriodicalId":14408,"journal":{"name":"International Journal of STD & AIDS","volume":" ","pages":"935-943"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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