国际医药卫生导报最新文献

{"title":"Diagnostic value of PCT level detection combined with bacterial culture in lower respiratory tract infection","authors":"Z. Hui, Li Jiameng","doi":"10.3760/CMA.J.ISSN.1007-1245.2019.23.033","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.23.033","url":null,"abstract":"Objective \u0000To explore the diagnostic value of procalcitonin (PCT) level detection combined with bacterial culture in lower respiratory tract infection. \u0000 \u0000 \u0000Methods \u000088 patients with lower respiratory tract infection admitted to our hospital from March, 2017 to June, 2019 were selected as the research objects. According to the clinical diagnosis, they were divided into a bacterial infection group (44 cases) and a non-bacterial infection group (44 cases). 44 healthy people who underwent physical examination in our hospital at the same time were selected as a control group. The three groups were detected by electrochemical sandwich method. The sputum of the bacterial infection group was collected for bacterial culture. The PCT levels and positive rates of the three groups were compared; and the distribution of bacteria and the detection rate of bacterial culture in the bacterial culture group were counted. \u0000 \u0000 \u0000Results \u0000The PCT level of the bacterial infection group was higher than those of the non-bacterial infection group and the control group, with statistical differences (both P<0.05); the PCT level of the non-bacterial infection group was higher than that of control group, with a statistical difference (P<0.05). The positive rate of the bacterial infection group was higher than those of the non-bacterial infection group and the control group, with statistical differences (both P<0.05); the positive rate of the non-bacterial infection group was higher than that of the control group (P<0.05). The results of bacterial culture showed that 22 cases were positive, and the detection rate was 50.00%, with Pseudomonas aeruginosa accounting for 36.36%, Staphylococcus epidermidis 18.18%, Staphylococcus aureus 13.63%, Klebsiella pneumoniae 18.18%, pneumonia 18.18%, Streptococcus 4.55%, Escherichia coli 4.55%, and Enterobacter cloacae 4.55%. \u0000 \u0000 \u0000Conclusion \u0000PCT level detection combined with bacterial culture can improve the positive detection rate of lower respiratory tract infection, and provide important guidance for clinical identification of bacterial infection, non-bacterial infection, and clinical medication. \u0000 \u0000 \u0000Key words: \u0000Lower respiratory tract infection; PCT level detection; Bacterial culture","PeriodicalId":14405,"journal":{"name":"国际医药卫生导报","volume":"25 1","pages":"3917-3919"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44174739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of letrozole on characteristics and linear growth of boys in early and middle youth period","authors":"Peng Zijun","doi":"10.3760/CMA.J.ISSN.1007-1245.2019.23.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.23.011","url":null,"abstract":"Objective \u0000To analyze the effect of aromatase inhibitor letrozole on the characteristics and linear growth of boys in early and middle youth period. \u0000 \u0000 \u0000Methods \u0000Thirty children in early-middle youth period who were to be impaired in adult height and treated in our hospital from January, 2016 to January, 2018 were enrolled as a study group. They were treated with letrozole, 1.5 mg/m2 per day. And 30 healthy boys in the early and middle youth stage taking physical examination during the same time period were selected as a control group, and took no drug intervention. The growth characteristics and linear growth changes of the two groups before treatment and after 1 year’s treatment were compared. \u0000 \u0000 \u0000Results \u0000There were no statistical differences in bone age, age, BMI, testicular volume, and height between the study group and the control group before the intervention(all P>0.05). After the intervention, the bone age of the study group was significantly inhibited (P<0.05); the testicular volume of the study group was (7.3±2.8)ml, which was significantly higher than that of the control group [(4.5±1.2) ml, P<0.05]; The study group’s predicted adult height and insulin growth factor 1 (IGF-1) were significantly different from the control group’s (both P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The used of letrozole in boys in early and middle youth stage can effectively inhibit bone age, improve their final height, and achieve their linear growth. \u0000 \u0000 \u0000Key words: \u0000Growth characteristics; Letrozole; Bone growth; Aromatase inhibitor; Linear growth","PeriodicalId":14405,"journal":{"name":"国际医药卫生导报","volume":"25 1","pages":"3855-3856"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46956486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of palliative care in chronic diseases of advanced age","authors":"Xu Yongneng, Chen Yanli, Zhao Xueqin, X. Zhihong, L. Shao-ping, Peng Min, Ma Huixin","doi":"10.3760/CMA.J.ISSN.1007-1245.2019.23.051","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.23.051","url":null,"abstract":"The prevention and treatment of chronic diseases has been gradually paid attention to by public health, and palliative care for patients with chronic diseases has become the main focus. The research on palliative care in China started late, so the palliative care for patients with chronic diseases is rarely mentioned. This article describes the development process and current situation of palliative care for chronic diseases of the elderly at home and abroad, points out the reasons why the development of palliative care for chronic diseases is slow in mainland China, and proposes some suggestions for the development of palliative care for chronic diseases in mainland China according to the obstacles and foreign countries. \u0000 \u0000 \u0000Key words: \u0000Palliative care; Advanced age; Chronic diseases","PeriodicalId":14405,"journal":{"name":"国际医药卫生导报","volume":"25 1","pages":"3967-3970"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45659216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengzhan Shengmai capsule in treatment of lower extremity arteriosclerosis obliterans","authors":"G. Xuemei, Han Yu","doi":"10.3760/CMA.J.ISSN.1007-1245.2019.23.036","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.23.036","url":null,"abstract":"Objective \u0000To observe the clinical effect of Dengzhan Shengmai capsule in the treatment of lower extremity arteriosclerosis obliterans. \u0000 \u0000 \u0000Methods \u000060 patients were randomly divided into a control group and a treatment group, 30 for each group. The control group was treated with conventional western medicine alprostadil, while the treatment group was treated with oral Dengzhan Shengmai capsule on the basis of alprostadil, 2 capsules each time, three times a day. The two groups were treated for 14 days as a cycle and 4 cycles as a treatment course. The treatment effects were compared between these two groups. \u0000 \u0000 \u0000Results \u0000The total effective rate of the treatment group was 96.7%, and that of the control group 80.0% (P<0.05). After the treatment, the ABI and TBI increased significantly in both groups (all P<0.05), and the changes of ABI and TBI in the treatment group were more significant than those in the control group (both P<0.05). After the treatment, the internal diameters of the posterior femoral artery, the posterior tibial artery and the dorsal pedal artery of the two groups increased significantly (all P<0.05). In addition, the hemorheology and endothelium of the two groups were significantly improved after treatment, and were better in the treatment group (all P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Dengzhan Shengmai capsule is effective in treating lower extremity arteriosclerosis obliterans, through improving microcirculation, inhibiting thrombosis, and regulating the release of vascular endothelial factors. \u0000 \u0000 \u0000Key words: \u0000Dengzhan Shengmai capsule; Lower extremity arteriosclerosis obliterans; Efficacy","PeriodicalId":14405,"journal":{"name":"国际医药卫生导报","volume":"25 1","pages":"3926-3929"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49634641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effects of butorphanol combined with dexmedetomidine versus propofol in fiberoptic bronchoscopy","authors":"Z. Lei, Z. Jinhua, He Jian, He Wanyou, Xiong Qingming, Wang Han-bing","doi":"10.3760/CMA.J.ISSN.1007-1245.2019.23.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.23.009","url":null,"abstract":"Objective \u0000To observe the clinical effect of butorphanol combined with dexmedetomidine or propofol in fiberoptic bronchoscopy. \u0000 \u0000 \u0000Methods \u0000Fifty patients undergoing fiberoptic bronchoscopy in our hospital from February to August, 2019 were randomly divided into group A and group B, 25 cases for each group. All the patients were subjected to topical anesthesia with lidocaine aerosol. In group A, dexmedetomidine was infused intravenously at 0.5 μg/kg for 15 minutes, maintained at 0.5 μg/(kg·h); and butorphanol was infused intravenously at 0.02 mg/kg 5 minutes before examination. In group B, 0.02 mg/kg butorphanol was injected intravenously 5 minutes before the examination, and plasma target-controlled propofol was given 3 μg/ml. The hemodynamic parameters, such as MAP, HR, and SPO2, as well as anesthesia effect and adverse reactions were recorded at the times of entry (T1), arrival of glottis (T2), passage of tracheal carina (T3), diagnosis and treatment (T4), and withdrawal from fiberoptic bronchoscopy (T5). \u0000 \u0000 \u0000Results \u0000At T2, T3, and T4, the mean blood pressures and the heart rates were lower in group A than in group B [(81±10) mmHg vs. (101±12) mmHg, (86±12) mmHg vs. (98±9) mmHg, (85 ±9) mmHg vs. (92±13) mmHg, (68±8) times/min vs. (98±12) times/min, (72±8) times/min vs. (88±11) times/min, and (70±9) times/min vs. (85±12) times/min; all P 0.05). No nausea or vomiting occurred in both groups. \u0000 \u0000 \u0000Conclusion \u0000The application of butorphanol and dexmedetomidine in fiberoptic bronchoscopy is safe and feasible, with good anesthetic effect and few adverse reactions. \u0000 \u0000 \u0000Key words: \u0000Dexmedetomidine; Butorphanol; Target control; Propofol; Fiberoptic bronchoscopy","PeriodicalId":14405,"journal":{"name":"国际医药卫生导报","volume":"25 1","pages":"3849-3852"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42836579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of hazard vulnerability analysis in hospital emergency management","authors":"Liu Tingzhi, Wang Cuiyu, C. Ang, F. Simao","doi":"10.3760/CMA.J.ISSN.1007-1245.2019.23.052","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.23.052","url":null,"abstract":"Objective \u0000To explore the application of hazard vulnerability analysis (HVA) in hospital emergency management, and to improve hospital emergency prevention capabilities. \u0000 \u0000 \u0000Methods \u0000Using the commonly used risk assessment matrix in China, 255 different positions and different personnel levels were selected to identify the potential hazards faced by the hospital; risk assessment and sequencing were carried out; and various hazard risk levels were identified. \u0000 \u0000 \u0000Results \u0000Through the hospital HVA, the top six risk factors were typhoon (46.00%), elevator accident (37.20%), public health emergency (30.00%), information system failure (27.00%), fire (26.00%), and power failure (25.50%). We identified the sudden risk events that the hospital needed to respond to and the key management projects. \u0000 \u0000 \u0000Conclusion \u0000HVA is an important basis for hospitals to identify and reduce risks. The weakest links in hospitals are identified, and the major emergencies that hospitals need to deal with are identified. Therefore, appropriate prevention and response measures are adopted in an organized, planned, and focused manner. It is of great significance to continuously improve the hospital emergency management capabilities ensuring the safety of life and property in hospitals and of doctors. \u0000 \u0000 \u0000Key words: \u0000Hazard vulnerability; Hospital; Emergency management; Risk","PeriodicalId":14405,"journal":{"name":"国际医药卫生导报","volume":"25 1","pages":"3971-3975"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41891428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression difference and significance of glucocorticoid receptor gene (NR3C1) in renal clear cell carcinoma","authors":"Chen Yang, Su Zhijian, Li Guanjun, Xie Cankun, C. Jie","doi":"10.3760/CMA.J.ISSN.1007-1245.2019.23.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.23.002","url":null,"abstract":"Objective \u0000To analyze the expression difference and significance of glucocorticoid receptor gene (NR3C1) in renal clear cell carcinoma. \u0000 \u0000 \u0000Methods \u0000The Oncomine database was used to retrieve and screen out the information of NR3C1, so as to obtain the expressions of NR3C1 in ccRCC and normal kidney tissues. The GEPIA database was used to analyze the relationship between the expression of NR3C1 and the survival rate of ccRCC patients in TCGA data. Protein interaction on one hand and upstream and downstream regulation of NR3C1 gene on the other hand were analyzed by the String database. \u0000 \u0000 \u0000Results \u0000The NR3C1 expression in ccRCC tissue was statistically different from that in normal renal tissue (P<0.05). The overall survival rate of the patients with a high NR3C1 expression was significantly higher than that of ones with a low NR3C1 expression (P<0.05). NR3C1 interacted with NCOA1, NCOA2, NOCRO1, HSP90AA1, FKBP5, and other proteins, and participates in inflammatory response, as well as in cell proliferation and differentiation and other biological processes. \u0000 \u0000 \u0000Conclusion \u0000NR3C1 is highly expressed in ccRCC and is related to the prognosis of ccRCC, so it can be used as a potential target for diagnosis and treatment. \u0000 \u0000 \u0000Key words: \u0000Renal clear cell carcinoma; ccRCC; Glucocorticoid receptor gene; NR3C1; Data mining; Oncomine","PeriodicalId":14405,"journal":{"name":"国际医药卫生导报","volume":"126 1","pages":"3827-3830"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69927467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of root cause analysis management in multidrug resistant Acinetobacter baumannii infection in ICU ward","authors":"Chen Wenqi, Chen Fengnan, Peng Ai-xia","doi":"10.3760/CMA.J.ISSN.1007-1245.2019.22.038","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.22.038","url":null,"abstract":"Objective \u0000To apply root cause analysis management in multidrug resistant Acinetobacter baumannii infection in ICU ward. \u0000 \u0000 \u0000Methods \u0000Six patients infected with multi-drug resistant Acinetobacter baumannii in ICU ward of our hospital were selected as the study object in February 2018. The instrument and equipment in ICU ward, the surface of bed unit, the diagnosis and treatment instrument, the sanitary ware, hands of medical staff and so on, were sampled. The root cause analysis method was used to find the source of infection and the route of transmission. The root causes of the outbreak of multi-drug resistant Acinetobacter baumannii were summarized and analyzed, and the intervention measures were taken. \u0000 \u0000 \u0000Results \u0000A total of 48 ICU environmental specimens were collected from 6 patients, of which 30 samples were positive showed by etiological examination, and the isolated strains were basically consistent with their drug resistance results (resistance to more than three types of antibiotics). It was inferred that the nosocomial infection of Acinetobacter baumannii in this outbreak was caused by the same pathogen contamination. At the same time, the detection results of Acinetobacter baumannii in ICU environment showed that the contamination of bed units and most of the surface of objects in the ward (the detection rate was 66%-75%), the disinfection and isolation measures not in place, and the non-standard hand hygiene of the staff were the main causes of the outbreak of nosocomial infection. \u0000 \u0000 \u0000Conclusions \u0000The main causes of the spread of multi-drug resistant Acinetobacter baumannii infection of ICU were found by root cause analysis, and the standard manual hygiene and contact isolation standards should be formulated and strictly implemented. It is an effective way to reduce the incidence of nosocomial infection of MDRAB by disinfection and sterilization measures on the surface of objects and the environment in the ward. There were no cases of multidrug resistant Acinetobacter baumannii infection in April 2018. \u0000 \u0000 \u0000Key words: \u0000Root cause analysis; ICU; Multidrug resistance; Acinetobacter baumannii; Nosocomial infection","PeriodicalId":14405,"journal":{"name":"国际医药卫生导报","volume":"25 1","pages":"3774-3776"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46345060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of peripherally inserted central catheter infection in patients with lung cancer undergoing chemotherapy","authors":"Zhang Shasha, Dan Guoyong, Li Xingan","doi":"10.3760/CMA.J.ISSN.1007-1245.2019.22.027","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.22.027","url":null,"abstract":"Objective \u0000To study the risk factors of peripherally inserted central catheter (PICC) infection in patients with lung cancer undergoing chemotherapy. \u0000 \u0000 \u0000Methods \u0000Medical records of 285 PICC patients with lung cancer treated in our hospital from February 2015 to October 2018 were retrospectively analyzed. The incidence of infection during PICC was recorded and the risk factors associated with infection were analyzed. \u0000 \u0000 \u0000Results \u0000Among 285 patients, there were 33 cases of PICC infection, with the infection rate of 11.58%. Catheterization in summer, the working time of catheterization staff less than 5 years, the times of catheterization more than 2 times, and the catheter retention time more than 30 days, diabetes history were independent risk factors for PICC infection (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Catheterization in summer, the working time of catheterization staff less than 5 years, the times of catheterization more than 2 times, and the catheter retention time more than 30 days, diabetes history were independent risk factors for PICC infection in lung cancer patients treated with chemotherapy. \u0000 \u0000 \u0000Key words: \u0000Lung cancer; Chemotherapy; Peripherally inserted central catheter; Risk factors; Infection","PeriodicalId":14405,"journal":{"name":"国际医药卫生导报","volume":"25 1","pages":"3744-3746"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45056709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the study of ASXL1 mutations in myeloid neoplasms","authors":"Fan Lirui","doi":"10.3760/CMA.J.ISSN.1007-1245.2019.21.052","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.21.052","url":null,"abstract":"In recent years, many studies on myeloid neoplasms have reported the occurrence of ASXL1 mutations, including myeloproliferative neoplasms (5%-35%), myelodysplastic syndrome (15%-50%), acute myelogenous leukemia (5%-15%), and so on. ASXL1 mutations include three types: frame-shift mutation, nonsense mutation, and missense mutation; among which, the first two have a great impact on the overall survival rate and disease-free survival rate of patients with myeloid neoplasms. At the same time, myeloid neoplasms patients with ASXL1 mutations have obvious clinical characteristics, and have significant differences in response to treatment and in prognosis compared with wild-type patients. The universality of ASXL1 mutation indicates that it is closely related to the occurrence and progress of myeloid neoplasms. In this paper, based on the current research data, the molecular structure and mutation characteristics of ASXL1 and its relationship with various myeloid tumors are reviewed. \u0000 \u0000 \u0000Key words: \u0000ASXL1 mutations; Myeloid neoplasms; Research progress","PeriodicalId":14405,"journal":{"name":"国际医药卫生导报","volume":"25 1","pages":"3657-3660"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46785764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}