Chen Yang, Su Zhijian, Li Guanjun, Xie Cankun, C. Jie
{"title":"糖皮质激素受体基因NR3C1在肾透明细胞癌中的表达差异及意义","authors":"Chen Yang, Su Zhijian, Li Guanjun, Xie Cankun, C. Jie","doi":"10.3760/CMA.J.ISSN.1007-1245.2019.23.002","DOIUrl":null,"url":null,"abstract":"Objective \nTo analyze the expression difference and significance of glucocorticoid receptor gene (NR3C1) in renal clear cell carcinoma. \n \n \nMethods \nThe Oncomine database was used to retrieve and screen out the information of NR3C1, so as to obtain the expressions of NR3C1 in ccRCC and normal kidney tissues. The GEPIA database was used to analyze the relationship between the expression of NR3C1 and the survival rate of ccRCC patients in TCGA data. Protein interaction on one hand and upstream and downstream regulation of NR3C1 gene on the other hand were analyzed by the String database. \n \n \nResults \nThe NR3C1 expression in ccRCC tissue was statistically different from that in normal renal tissue (P<0.05). The overall survival rate of the patients with a high NR3C1 expression was significantly higher than that of ones with a low NR3C1 expression (P<0.05). NR3C1 interacted with NCOA1, NCOA2, NOCRO1, HSP90AA1, FKBP5, and other proteins, and participates in inflammatory response, as well as in cell proliferation and differentiation and other biological processes. \n \n \nConclusion \nNR3C1 is highly expressed in ccRCC and is related to the prognosis of ccRCC, so it can be used as a potential target for diagnosis and treatment. \n \n \nKey words: \nRenal clear cell carcinoma; ccRCC; Glucocorticoid receptor gene; NR3C1; Data mining; Oncomine","PeriodicalId":14405,"journal":{"name":"国际医药卫生导报","volume":"126 1","pages":"3827-3830"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expression difference and significance of glucocorticoid receptor gene (NR3C1) in renal clear cell carcinoma\",\"authors\":\"Chen Yang, Su Zhijian, Li Guanjun, Xie Cankun, C. Jie\",\"doi\":\"10.3760/CMA.J.ISSN.1007-1245.2019.23.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo analyze the expression difference and significance of glucocorticoid receptor gene (NR3C1) in renal clear cell carcinoma. \\n \\n \\nMethods \\nThe Oncomine database was used to retrieve and screen out the information of NR3C1, so as to obtain the expressions of NR3C1 in ccRCC and normal kidney tissues. The GEPIA database was used to analyze the relationship between the expression of NR3C1 and the survival rate of ccRCC patients in TCGA data. Protein interaction on one hand and upstream and downstream regulation of NR3C1 gene on the other hand were analyzed by the String database. \\n \\n \\nResults \\nThe NR3C1 expression in ccRCC tissue was statistically different from that in normal renal tissue (P<0.05). The overall survival rate of the patients with a high NR3C1 expression was significantly higher than that of ones with a low NR3C1 expression (P<0.05). NR3C1 interacted with NCOA1, NCOA2, NOCRO1, HSP90AA1, FKBP5, and other proteins, and participates in inflammatory response, as well as in cell proliferation and differentiation and other biological processes. \\n \\n \\nConclusion \\nNR3C1 is highly expressed in ccRCC and is related to the prognosis of ccRCC, so it can be used as a potential target for diagnosis and treatment. \\n \\n \\nKey words: \\nRenal clear cell carcinoma; ccRCC; Glucocorticoid receptor gene; NR3C1; Data mining; Oncomine\",\"PeriodicalId\":14405,\"journal\":{\"name\":\"国际医药卫生导报\",\"volume\":\"126 1\",\"pages\":\"3827-3830\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际医药卫生导报\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.23.002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际医药卫生导报","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1007-1245.2019.23.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Expression difference and significance of glucocorticoid receptor gene (NR3C1) in renal clear cell carcinoma
Objective
To analyze the expression difference and significance of glucocorticoid receptor gene (NR3C1) in renal clear cell carcinoma.
Methods
The Oncomine database was used to retrieve and screen out the information of NR3C1, so as to obtain the expressions of NR3C1 in ccRCC and normal kidney tissues. The GEPIA database was used to analyze the relationship between the expression of NR3C1 and the survival rate of ccRCC patients in TCGA data. Protein interaction on one hand and upstream and downstream regulation of NR3C1 gene on the other hand were analyzed by the String database.
Results
The NR3C1 expression in ccRCC tissue was statistically different from that in normal renal tissue (P<0.05). The overall survival rate of the patients with a high NR3C1 expression was significantly higher than that of ones with a low NR3C1 expression (P<0.05). NR3C1 interacted with NCOA1, NCOA2, NOCRO1, HSP90AA1, FKBP5, and other proteins, and participates in inflammatory response, as well as in cell proliferation and differentiation and other biological processes.
Conclusion
NR3C1 is highly expressed in ccRCC and is related to the prognosis of ccRCC, so it can be used as a potential target for diagnosis and treatment.
Key words:
Renal clear cell carcinoma; ccRCC; Glucocorticoid receptor gene; NR3C1; Data mining; Oncomine
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