Chemistry - A European Journal最新文献

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry. 将键合转化为功能：生物活性硒─金属基序在毒理学和药物化学中的新作用。

IF 3.6 2区化学

Chemistry - A European Journal Pub Date : 2026-09-04 DOI: 10.1002/chem.71645

Matteo Filippi, Alessandro Rubbi, Pablo A Nogara, Giovanni Ribaudo, Vito Lippolis, João B T Rocha, Laura Orian

{"title":"Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry.","authors":"Matteo Filippi, Alessandro Rubbi, Pablo A Nogara, Giovanni Ribaudo, Vito Lippolis, João B T Rocha, Laura Orian","doi":"10.1002/chem.71645","DOIUrl":"https://doi.org/10.1002/chem.71645","url":null,"abstract":"The synthesis and characterization of organo-selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired antioxidants; the investigation and exploitation of selenium─metal motifs in biological and medicinal chemistry represent a recent development and constitute the focus of this review. Selenoproteins are targets of metal ions like mercury and cadmium, whose toxicity is associated with the formation of stable selenium─metal bonds impairing protein function. On the other hand, selenium─metal bonding provides a strategy for tuning both chalcogen and metal reactivity, potentially enhancing the pharmacological performance of metallodrugs. Coordination to transition metals can modify redox potentials, bond polarization, and reactivity, thereby enabling multifunctional compounds combining metal-based pharmacophores with the redox activity of selenium. These systems may modulate reactive oxygen species, inhibit enzymes, and enhance selective cytotoxicity toward cancer cells. The formation of selenium─metal bonds in biological environment can also alter the function of metalloproteins, accounting for the toxicity of organoselenides. By combining experimental structural and reactivity properties with mechanistic insights from computational chemistry, we highlight the unifying concepts that govern selenium─metal bonding and to illustrate how these concepts can guide the rational design of new classes of selenium-based functional molecules.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e71645"},"PeriodicalIF":3.6,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Highly Robust Y-Based Framework for Sustainable Catalysis and Synthesis of Bioactive Chromeno[2,3-d]Pyrimidin-8-Amine Derivatives. 生物活性染料[2,3-d]嘧啶-8-胺衍生物可持续催化合成的高度稳健框架。

IF 3.6 2区化学

Chemistry - A European Journal Pub Date : 2026-09-04 DOI: 10.1002/chem.71648

Bikram Pramanik, Rupam Sahoo, Sayan Palit, Madhab C Das

{"title":"A Highly Robust Y-Based Framework for Sustainable Catalysis and Synthesis of Bioactive Chromeno[2,3-d]Pyrimidin-8-Amine Derivatives.","authors":"Bikram Pramanik, Rupam Sahoo, Sayan Palit, Madhab C Das","doi":"10.1002/chem.71648","DOIUrl":"https://doi.org/10.1002/chem.71648","url":null,"abstract":"The synthesis of bioactive molecules through one-pot multicomponent reactions under mild conditions is of significant interest for medicinal chemistry, though largely unexplored and challenging. Herein, we have reported a new Y(III)-based chemically stable framework, IITKGP-65, with abundant active catalytic sites, which exhibited excellent stability in open air, water, and even in acidic medium. The activated framework, IITKGP-65a, has been utilized as a Lewis acid-driven heterogeneous catalyst for the synthesis of bioactive chromeno[2,3-d]pyrimidin-8-amine derivatives. Notably, synthesis of these compounds has not yet been reported in the literature using any coordination polymer (CP) or metal-organic framework (MOF)-based catalyst. Interestingly, a good to excellent yield was achieved even with a low catalyst loading of our developed catalyst for a wide range of substrate scopes, along with excellent recyclability without any loss of structural integrity. Most importantly, to demonstrate practical applicability, we synthesized four chromeno[2,3-d]pyrimidin-8-amine derivatives exhibiting antibacterial activity using a green ethanol medium. The facile accessibility, robust structural framework, outstanding catalytic performance, and excellent recyclability collectively underscore the potential of the developed framework, IITKGP-65, as an efficient catalyst. Furthermore, these attributes extend its applicability to the environmentally friendly synthesis of complex bioactive molecules.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e71648"},"PeriodicalIF":3.6,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-Coordinate 13-Electron Pd^I Complexes Stabilized by the Bulky DIMeIHept^Cl NHC Ligand. 大体积DIMeIHeptCl NHC配体稳定的二坐标13电子PdI配合物。

IF 3.6 2区化学

Chemistry - A European Journal Pub Date : 2026-09-04 DOI: 10.1002/chem.71649

Volodymyr Semeniuchenko, Sepideh Sharif, Neha Rana, Nalin Chandrasoma, Wilfried M Braje, R Tom Baker, Jeffrey M Manthorpe, William J Pietro, Michael G Organ

{"title":"Two-Coordinate 13-Electron PdI Complexes Stabilized by the Bulky DIMeIHeptCl NHC Ligand.","authors":"Volodymyr Semeniuchenko, Sepideh Sharif, Neha Rana, Nalin Chandrasoma, Wilfried M Braje, R Tom Baker, Jeffrey M Manthorpe, William J Pietro, Michael G Organ","doi":"10.1002/chem.71649","DOIUrl":"https://doi.org/10.1002/chem.71649","url":null,"abstract":"Monomeric, two-coordinate 13-electron PdI complexes are exceptionally rare due to their intrinsic instability and propensity for dimerization. In this study, we report that the bulky N-heterocyclic carbene (NHC) ligand DiMeIHeptCl (1,3-bis[2,6-bis(1-propylbutyl)phenyl]-4,5-dichloro-1,3-dihydro-2H-imidazol-2-ylidene) enables the generation and stabilization of a series of such species. Reduction of the dichloro PdII precursor affords PdCl(DiMeIHeptCl) (3), which serves as a platform for accessing Pd(OtBu)(DiMeIHeptCl) (4), Pd[N(SiMe3)2](DiMeIHeptCl) (5), and Pd(NH-2,4,6-tri-tertbutyl-C6H2)(DiMeIHeptCl) (6). These complexes adopt pseudolinear or bent geometries, as established by EPR spectroscopy, x-ray crystallography, and DFT calculations. Complexes 3 and 4 react with nucleophiles by an associative mechanism, which becomes impossible for sterically over-crowded 5. Kinetic and spectroscopic studies reveal divergent decay pathways, with 3 undergoing disproportionation and 4-6 decomposing via Pd─X bond homolysis to generate Pd0 species and transient organic radicals. Notably, these PdI complexes do not undergo oxidative addition with aryl halides, excluding PdI/III reactivity under these conditions. Electronic structure analysis shows the unpaired electron resides primarily on Pd and the X ligand, with minimal NHC involvement. These findings provide insight into low-coordinate PdI intermediates that may prove relevant to Pd(NHC) precatalyst activation.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e71649"},"PeriodicalIF":3.6,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Azaphenalenone Derivatives Using Aldrone Condensation and Evaluation of Their Anticancer Activities. 醛酮缩合法合成氮杂酚烯酮衍生物及其抗癌活性评价。

IF 3.6 2区化学

Chemistry - A European Journal Pub Date : 2026-09-04 DOI: 10.1002/chem.71630

Priya Jayathsena R, Uzini Devi Daimary, Ajaikumar B Kunnumakkara, Kingsuk Mahata

引用次数: 0

Illuminating Olympicenes: Insights Into Anti-Kasha Photophysics in Polycyclic Aromatic Hydrocarbons. 照亮奥林匹克：洞察多环芳烃的反卡沙光物理。

IF 3.6 2区化学

Chemistry - A European Journal Pub Date : 2026-09-04 DOI: 10.1002/chem.71657

Wenlong Li, Stephen Awuku, Mia E Dionne, Jordyn L Gunderson, Marc R MacKinnon, Amy L Stevens

{"title":"Illuminating Olympicenes: Insights Into Anti-Kasha Photophysics in Polycyclic Aromatic Hydrocarbons.","authors":"Wenlong Li, Stephen Awuku, Mia E Dionne, Jordyn L Gunderson, Marc R MacKinnon, Amy L Stevens","doi":"10.1002/chem.71657","DOIUrl":"https://doi.org/10.1002/chem.71657","url":null,"abstract":"Olympicene, or 6H-benzo[cd]pyrene, is a polycyclic aromatic hydrocarbon (PAH) with five fused six-membered rings arranged in a pattern reminiscent of the Olympic symbol. While functionalized olympicene-based materials have captivated attention for their unique graphene-fragment topology and aromaticity, their photoluminescent properties remain virtually unexplored. Here, we synthesize olympicene-core functionalized derivatives and report their \"anomalous\" photophysical properties. These olympicene derivatives display extensive vibronic structure and highly interacting electronic states. Such effects give rise to excited-state dynamics that are rare and unconventional in small PAH systems. Specifically, these olympicene derivatives exhibit dual fluorescence upon photoexcitation, accompanied by pronounced excitation-dependent emission behavior. Spectroscopic evidence demonstrates these behaviors arise from multiple singlet emissive states-an anti-Kasha locally excited (LE) state (Sn, n ≥ 2) and an intramolecular charge transfer (ICT) state. This work positions olympicene-functionalized derivatives as a new platform to study fundamental photophysics. Exploring these properties will lead to new and advanced optoelectronic applications.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e71657"},"PeriodicalIF":3.6,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Si(OTeF₅)₄ - A Strong, Homoleptic Pentafluoroorthotellurate-Based Lewis Superacidic Silane. Si(OTeF5)4 -一种强同感的五氟正碲酸盐基路易斯超酸性硅烷。

IF 3.6 2区化学

Chemistry - A European Journal Pub Date : 2026-09-04 DOI: 10.1002/chem.71639

Friederike Oesten, Niklas Limberg, Anja Wiesner, Simon Steinhauer, Lukas Fischer, Sebastian Riedel

引用次数: 0

Correction to "Scandium-Catalyzed Highly Selective Deoxygenation of Alcohols by Using Hydrosilanes as Reductants". 对“用氢硅烷作还原剂钪催化醇的高选择性脱氧”的修正。

IF 3.6 2区化学

Chemistry - A European Journal Pub Date : 2026-09-03 DOI: 10.1002/chem.71474

引用次数: 0

Synthesis and Photophysical Properties of Star-Shaped Triphenylamine Trimers Functionalized With BODIPY and Subphthalocyanine Chromophores. 用BODIPY和亚酞菁发色团功能化的星形三苯胺三聚体的合成及其光物理性质。

IF 3.6 2区化学

Chemistry - A European Journal Pub Date : 2026-09-03 DOI: 10.1002/chem.71641

Habiba Boughanmi, Paula de la Rubia, Jamel-Eddine Khiari, Tomás Torres, José García-Calvo

{"title":"Synthesis and Photophysical Properties of Star-Shaped Triphenylamine Trimers Functionalized With BODIPY and Subphthalocyanine Chromophores.","authors":"Habiba Boughanmi, Paula de la Rubia, Jamel-Eddine Khiari, Tomás Torres, José García-Calvo","doi":"10.1002/chem.71641","DOIUrl":"https://doi.org/10.1002/chem.71641","url":null,"abstract":"This work reports the synthesis, characterization, and solution photophysical properties of para-trisubstituted triphenylamine (TPA) derivatives that preserve the threefold symmetry around the central nitrogen atom. By functionalizing the TPA core with three units of one of two representative boron-containing chromophores-BODIPY and subphthalocyanine (SubPc)-we directly compare how chromophore identity and molecular topology determine the optical response of the resulting star-shaped architectures. Whereas neither family exhibits significant solvatochromism in absorption, their fluorescence is strongly governed by both the solvent and the molecular architecture. The SubPc-based trimer undergoes efficient fluorescence quenching in all but the least polar solvent studied (Φ ≤ 2%, partially restored to 10% in methylcyclohexane), consistent with an effective intramolecular excited-state deactivation pathway. In contrast, the BODIPY-based trimer remains strongly quenched in polar media while developing a new red-shifted emission band (λem = 606 nm) with a markedly enhanced fluorescence quantum yield (Φ = 26%) in toluene. Comparison with the corresponding monomeric reference compounds demonstrates that these distinctive photophysical properties arise primarily from the threefold star-shaped architecture rather than from the intrinsic optical properties of the individual chromophores. These findings establish molecular topology as an effective design parameter for tuning excited-state dynamics in multichromophoric TPA-based systems.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e71641"},"PeriodicalIF":3.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Access to Uncharted (Ethoxy)difluoromethylated-Containing Tetrahydrofurans by Hydrogenation. 通过加氢获得未知的（乙氧基）含二氟甲基化四氢呋喃。

IF 3.6 2区化学

Chemistry - A European Journal Pub Date : 2026-09-03 DOI: 10.1002/chem.71545

Thibaud Charvillat, Victor Levet, Patrick Bernardelli, Marc Daumas, Hassan Oulyadi, Muriel Sebban, Vincent Ferey, Tatiana Besset

{"title":"Access to Uncharted (Ethoxy)difluoromethylated-Containing Tetrahydrofurans by Hydrogenation.","authors":"Thibaud Charvillat, Victor Levet, Patrick Bernardelli, Marc Daumas, Hassan Oulyadi, Muriel Sebban, Vincent Ferey, Tatiana Besset","doi":"10.1002/chem.71545","DOIUrl":"https://doi.org/10.1002/chem.71545","url":null,"abstract":"Fluorinated (hetero)cyclic compounds have garnered attention over the years, offering key building blocks in medicinally relevant molecules. However, the synthesis of fluorinated tetrahydrofurans remains a synthetic challenge to reach. Herein, we developed an efficient and robust approach for the synthesis of cis-(ethoxycarbonyl)difluoromethylated tetrahydrofurans. Using the inexpensive Pd/C catalyst, the diastereoselective hydrogenation of functionalized CF2CO2Et-containing furans was achieved under mild reaction conditions. Access to unprecedented cis-fluorinated tetrahydrofurans with isolated yields of up to 74% and diastereomeric ratios up to 95:5 (12 examples) was reached. Pleasingly, under slightly modified reaction conditions, 5-arylated CF2CO2Et-containing furans were smoothly converted into the valuable α,α-difluoro-β-hydroxyesters (five examples, up to 66% yield). Overall, the protocol exhibited good functional-group tolerance and was easily scaled up. The synthetic utility of the CF2CO2Et moiety was further illustrated by its conversion into various other fluorinated groups.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e71545"},"PeriodicalIF":3.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On-Demand Hydrogen Supply Over Co-Cu Bimetallic Sulfide Nanoflowers for Efficient Electrocatalytic Nitrate Reduction to Ammonia. 在Co-Cu双金属硫化物纳米花上按需供氢，用于高效电催化硝酸还原为氨。

IF 3.6 2区化学

Chemistry - A European Journal Pub Date : 2026-09-03 DOI: 10.1002/chem.71663

Cheng Song, Tinghui Liu, Xiaohui Yang, Xingzu Wang, Hong Liu

{"title":"On-Demand Hydrogen Supply Over Co-Cu Bimetallic Sulfide Nanoflowers for Efficient Electrocatalytic Nitrate Reduction to Ammonia.","authors":"Cheng Song, Tinghui Liu, Xiaohui Yang, Xingzu Wang, Hong Liu","doi":"10.1002/chem.71663","DOIUrl":"https://doi.org/10.1002/chem.71663","url":null,"abstract":"Electrocatalytic nitrate (NO3 -) reduction offers a sustainable route for simultaneous NO3 - remediation and ammonia (NH3) production, yet its efficiency is limited by the competing hydrogen evolution reaction (HER) and the imbalance between NO3 - activation and hydrogen supply. Herein, Co-Cu bimetallic sulfide nanoflowers were synthesized via a one-step hydrothermal method and optimized for NO3 - to NH3 conversion. The Co0.9Cu0.1S nanoflowers, assembled from two-dimensional nanosheets, delivered 97.83% ± 1.71% nitrate conversion, nearly complete NH4 +-N selectivity, and a Faradaic efficiency of 98.52% ± 0.83% at -0.75 V vs. RHE. Systematic Co/Cu-ratio studies, electrochemical kinetics, Bode analysis, hydrogen adsorption/desorption behavior, and XPS results reveal that Cu promotes NO3 - activation and electronically modulates Co sites, while Co facilitates reactive hydrogen generation and utilization. This synergy enables on-demand hydrogen supply, directing hydrogen toward NO3 - hydrogenation rather than HER. pH-dependent tests further identify a neutral electrolyte as favorable for balancing proton supply and competitive HER.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e71663"},"PeriodicalIF":3.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0