Chemistry - A European Journal最新文献

Cover Feature: A CH4-Driven Ion Cloud-Stretched Approach Enables ICP-qMS for Multiplex Single-Cell Analysis (Chem. Eur. J. 71/2024)

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2024-12-18 DOI: 10.1002/chem.202487104

Zhengxian Lv, Xinli Yan, Zhen Liu, Shi Chen, Xiaowen Yan, Limin Yang, Qiuquan Wang

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Front Cover: Preferential Formation of Three-layered Host–Guest Complexes of a Planar Dinuclear Metallohost with Alkali Metal Ions (Chem. Eur. J. 71/2024)

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2024-12-18 DOI: 10.1002/chem.202487101

Shigehisa Akine, Masato Nakano, Yoko Sakata, Sachiko Yano

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Cover Feature: Unveiling the Ultrafast Excitation Energy Transfer in Tetraarylpyrrolo[3,2-b]pyrrole-BODIPY Dyads (Chem. Eur. J. 71/2024)

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2024-12-18 DOI: 10.1002/chem.202487102

Sudip Gorai, Richa Agrawal, Rajib Ghosh, Soumyaditya Mula

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Cover Feature: Photocatalytic Seawater Splitting by Earth-Abundant Catalysts: Metal-Semiconductor Metamaterials Made of Plasmonic Magnesium Diboride and Transitional Metal Dichalcogenides (Chem. Eur. J. 71/2024)

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2024-12-18 DOI: 10.1002/chem.202487103

Hongkai Zhou, Alexander N. Grigorenko, Vasyl G. Kravets

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Fisetin as a Blueprint for Senotherapeutic Agents - Elucidating Geroprotective and Senolytic Properties with Molecular Modeling.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2024-12-17 DOI: 10.1002/chem.202403755

Maciej Spiegel

{"title":"Fisetin as a Blueprint for Senotherapeutic Agents - Elucidating Geroprotective and Senolytic Properties with Molecular Modeling.","authors":"Maciej Spiegel","doi":"10.1002/chem.202403755","DOIUrl":"https://doi.org/10.1002/chem.202403755","url":null,"abstract":"Targeting senescent cells and the factors that accelerate this pathological state has recently emerged as a novel field in medicinal chemistry. As attention shifts to synthetic substances, studies on natural agents are often overlooked. In this paper, we present a detailed computational modeling study that encompasses quantum mechanics and molecular dynamics to elucidate the senotherapeutic activity of fisetin. The mitochondrial environment, serving as a proxy for senescence, received special attention. Throughout the study, fisetin's outstanding geroprotective properties-exhibiting significant potential against •OOH, O2•-, and •OH radicals, surpassing those of Trolox or ascorbate-were identified. Furthermore, fisetin demonstrated a high capacity to restore oxidatively damaged biomolecules to their pristine forms, thereby renewing the functionality of proteins and amino acids. The senolytic properties were examined in terms of Bcl-2 and Bcl-xL inhibition. The results indicated that fisetin not only binds effectively to these proteins but also, with appropriate modifications, may exhibit specific selectivity toward either target. This study highlights fisetin's remarkable activity in these areas and provides a molecular description of the underlying processes, paving the way for future research.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202403755"},"PeriodicalIF":3.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Helical Supramolecular Polymers Formed via Head-to-Tail Host-Guest Complexation of Chiral Bisporphyrin Monomers with Trinitrofluorenone.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2024-12-17 DOI: 10.1002/chem.202404210

Naoyuki Hisano, Tomoki Kodama, Soichiro Koya, Takeharu Haino

{"title":"Helical Supramolecular Polymers Formed via Head-to-Tail Host-Guest Complexation of Chiral Bisporphyrin Monomers with Trinitrofluorenone.","authors":"Naoyuki Hisano, Tomoki Kodama, Soichiro Koya, Takeharu Haino","doi":"10.1002/chem.202404210","DOIUrl":"https://doi.org/10.1002/chem.202404210","url":null,"abstract":"The intermolecular host-guest complexation of head-to-tail monomers consisting of cleft-shaped bisporphyrin and trinitrofluorenone units connected by a chiral binaphthyl linker was employed to construct helically twisted supramolecular polymers. Results from 1H NMR, diffusion-ordered NMR spectroscopy, and viscometry experiments revealed that the supramolecular polymerization of these monomers follows a ring-chain competition mechanism. The introduction of bulky substituents at the linker significantly suppressed the formation of macrocyclic oligomers, whereas smaller alkyl chains facilitated the formation of the cyclic form. The chirally twisted structures of the supramolecular polymers were confirmed using circular dichroism spectroscopy. Atomic force microscopy revealed that the (R)- and (S)-configurations of the binaphthyl linkers induced right- and left-handed helical structures, respectively, in the supramolecular polymer chains. The absence of cooperativity in the supramolecular copolymerization of (R)- and (S)-1a resulted in the formation of stereo-random supramolecular copolymers.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202404210"},"PeriodicalIF":3.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Inter- and intra-molecular charge redistributions in H-bonded Cyanuric Acid*Melamine (CA*M) networks: insight from core level spectroscopy and natural bond orbital analysis.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2024-12-17 DOI: 10.1002/chem.202403782

Daniele Toffoli, Roberto Costantini, Elisa Bernes, Lorys Di Nardi, Gabriele Balducci, Elisa Viola, Giovanna Fronzoni, Albano Cossaro, Valeria Lanzilotto

{"title":"Inter- and intra-molecular charge redistributions in H-bonded Cyanuric Acid*Melamine (CA*M) networks: insight from core level spectroscopy and natural bond orbital analysis.","authors":"Daniele Toffoli, Roberto Costantini, Elisa Bernes, Lorys Di Nardi, Gabriele Balducci, Elisa Viola, Giovanna Fronzoni, Albano Cossaro, Valeria Lanzilotto","doi":"10.1002/chem.202403782","DOIUrl":"https://doi.org/10.1002/chem.202403782","url":null,"abstract":"In this work, we elucidate the electronic charge redistributions that occur within the cyanuric acid (CA) and melamine (M) molecules upon formation of the triple H-bond between the imide group of CA and the diaminopyridine group of M. To achieve this, we investigated 2D H-bonded assemblies of M, CA and CA*M grown on the Au(111) surface, using X-ray photoemission (XPS) and near edge X-ray absorption fine structure (NEXAFS) spectroscopies. Compared to the homomolecular networks, the spectra of the mixed sample reveal core level shifts in opposite directions for CA and M, indicating a nearly complementary charge accumulation on the CA molecule and a charge depletion on the M molecule. These findings were further confirmed by theoretical simulation of the ionization potentials (IPs), which were computed using unsupported models of the H-bonded networks. A natural bond orbital (NBO) analysis performed on the three systems helped to rationalize the net charge transfer form M to CA. Finally, we observed that intramolecular interactions (electron delocalization effects) contribute progressively to the charge redistributions inside the two molecules when going from the homomolecular to the heteromolecular networks.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202403782"},"PeriodicalIF":3.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defluorinative Diazolation-Cyclization Relay for Synthesis of Furan-Bridged Triheterocycles and Colorimetric Sensor Application.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2024-12-17 DOI: 10.1002/chem.202404324

Man-Hang Feng, Da-Qing Chen, Shu-Ji Gao, Danhua Ge, Xiaojun Chen, Mengtao Ma, Zhi-Liang Shen, Xue-Qiang Chu

{"title":"Defluorinative Diazolation-Cyclization Relay for Synthesis of Furan-Bridged Triheterocycles and Colorimetric Sensor Application.","authors":"Man-Hang Feng, Da-Qing Chen, Shu-Ji Gao, Danhua Ge, Xiaojun Chen, Mengtao Ma, Zhi-Liang Shen, Xue-Qiang Chu","doi":"10.1002/chem.202404324","DOIUrl":"https://doi.org/10.1002/chem.202404324","url":null,"abstract":"Polyaromatics, as the assembly of diverse cyclic π-systems, exhibit unique physicochemical properties when compared to their individual constituents. In this study, we developed a strategic connection of two azacycles via a furan bridge through a defluorinative diazolation-cyclization reaction of trifluoromethyl enones and N-heterocycles. A range of modular 2,4-furan-bridged triheterocycles (FBTHs), featuring a C3-trifluoromethyl group, was synthesized with broad substrate scope and good regioselectivity under transition metal-free conditions. This three-component protocol was achieved through successive C(sp3)-F bond functionalization of one trifluoromethyl group, which is recognized for its stability and durability. Moreover, the synthetically useful functionalities such as bromide and formyl group could be easily installed on the resulting products, and the imidazole-containing FBTH could serve as a valuable ligand in the preparation of an advanced colorimetric sensor, thereby underscoring their potential applications.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202404324"},"PeriodicalIF":3.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The Impact of Single Amino Acid Insertion on the Supramolecular Assembly Pathway of Aromatic Peptide Amphiphiles. 单个氨基酸插入对芳香族肽两亲化合物超分子组装途径的影响

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2024-12-17 DOI: 10.1002/chem.202404233

Ayato Higuchi, Arka Som, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya, Pol Besenius

{"title":"The Impact of Single Amino Acid Insertion on the Supramolecular Assembly Pathway of Aromatic Peptide Amphiphiles.","authors":"Ayato Higuchi, Arka Som, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya, Pol Besenius","doi":"10.1002/chem.202404233","DOIUrl":"https://doi.org/10.1002/chem.202404233","url":null,"abstract":"Understanding the mechanism of self-assembly driven by non-covalent interactions is crucial for designing supramolecular materials with desired properties. Here we investigate the self-assembly of aromatic peptide amphiphiles, Fmoc-L2QG and Fmoc-L3QG using a combination of spectroscopic, transmission electron and superresolution optical microscopy techniques. Our results show that Fmoc-L2QG leads to concentration-dependent assembly, forming fibrous assemblies at low concentrations and supramolecular droplets via liquid-liquid phase separation (LLPS) at higher concentrations. Mechanical activation using for example ultrasonication triggered the transition from metastable droplets to fibre morphologies of Fmoc-L2QG. In contrast, Fmoc-L3QG followed both on-pathway and off-pathway routes, resulting in the formation of fibrous morphologies regardless of concentration. Seeding experiments revealed that homo-seeds of the same peptide sequence accelerated the on-pathway process, while hetero-seeds of a mismatched peptide sequences accelerated the off-pathway process, highlighting the competing nature of the complex assembly profile. These findings demonstrate the significant impact of single amino acid insertion on the supramolecular assembly process of oligopeptide monomers, and highlight the potential for controlling the structure and dynamics of peptide materials. Pathway engineering of oligopeptide building blocks and multidomain supramolecular monomers will open new avenues in tailor-made and customizable supramolecular biomaterials.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202404233"},"PeriodicalIF":3.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Towards White Light Emission Through Metal-to-Metal Charge Transfer (MMCT) Effect in Bi3+ Activated Ca2YTi2-mZrmGa3O12 (0 ≤ m ≤ 2) Garnets.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2024-12-17 DOI: 10.1002/chem.202404016

Gurusamy Sivakumar, Akkarakkaran Thayyil Muhammed Munthasir, Pakkirisamy Thilagar, Srinivasan Natarajan

{"title":"Towards White Light Emission Through Metal-to-Metal Charge Transfer (MMCT) Effect in Bi3+ Activated Ca2YTi2-mZrmGa3O12 (0 ≤ m ≤ 2) Garnets.","authors":"Gurusamy Sivakumar, Akkarakkaran Thayyil Muhammed Munthasir, Pakkirisamy Thilagar, Srinivasan Natarajan","doi":"10.1002/chem.202404016","DOIUrl":"https://doi.org/10.1002/chem.202404016","url":null,"abstract":"Herein, we report the high-temperature solid-state synthesis and intriguing optical features of Bi3+/Ln3+ doped Ca2YTi2Ga3O12 (CYT). The optical properties of CYT were fine-tuned by judiciously substituting Zr4+ ions at Ti4+ sites and Bi3+, Ln3+ ions at Y3+ sites. All these compounds are crystallized in a cubic crystal system with an Ia-3d (no. 230) space group. The Bi3+ doped systems showed a broad photoluminescence (PL) band in the yellow-orange region centered at ~552 nm from the metal-to-metal charge transfer state (MMCT). The yellow-orange emissive CYT:Bix was co-doped with blue emissive Tm3+ to obtain an excitation wavelength-dependent color tuneable white light phosphor CYT:Tm0.02Bi0.012. Substituting Zr4+ ions in place of Ti4+ ions in CYT gave rise to CYTZ (Ca2YTi2-mZrmGa3O12), which upon doping with Bi gave Ca2YZr2Ga3O12:Bix (CYZ:Bix) and they exhibit the 3P0,1 → 1S0 emission in the violet-indigo region (λem = 395 nm; λex = 315 nm). On co-doping CYTZ:Bix with Sm3+ ions produced white light emissive Ca2YTi0.1Zr1.9Ga3O12:Bi3+; Sm3+, (CYTZ:Bi3+; Sm3+). CYT:Bix showed slower (microsecond) PL decay than the CYZ:Bix (nanosecond). The crystal structure, steady state, and time-resolved optical studies, and semiempirical calculations were employed to rationalize the optical features. The optical features of CYT:Bi0.1, were explored for potential applications in secret writing.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202404016"},"PeriodicalIF":3.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0