Photo-enabled α-C(sp³)-H Functionalization of Sulfides.

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-10-21 DOI:10.1002/chem.202502638

Peng Cheng, Jie Ding, Zhenda Tan

引用次数: 0

Abstract

Sulfides hold significant value in fine chemicals and pharmaceuticals. Efficient α-C ─ H transformations of these compounds offer streamlined routes to value-added derivatives but pose substantial challenges due to high C ─ H BDEs and catalyst poisoning. Photochemical strategies have emerged as powerful solutions for enabling α-C(sp³)-H functionalization of sulfides. This review comprehensively surveys photo-enabled sulfide α-C ─ H functionalization methodologies, with particular focus on hydrogen atom transfer (HAT) and electron transfer/proton transfer (ET/PT) mechanisms.

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硫化物的光使能α-C(sp3)-H功能化。

硫化物在精细化学品和药品中具有重要的价值。这些化合物的高效α-C─H转化为增值衍生物提供了简化的途径，但由于高C─H BDEs和催化剂中毒，带来了实质性的挑战。光化学策略已成为使硫化物α-C(sp3)-H功能化的有力解决方案。本文综述了光使能硫化物α-C─H功能化方法，特别关注氢原子转移（HAT）和电子转移/质子转移（ET/PT）机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

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Photo-enabled α-C(sp3)-H Functionalization of Sulfides.

Abstract

Photo-enabled α-C(sp³)-H Functionalization of Sulfides.