硫化物的光使能α-C(sp3)-H功能化。

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-10-21 DOI:10.1002/chem.202502638

Peng Cheng, Jie Ding, Zhenda Tan

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引用次数: 0

摘要

硫化物在精细化学品和药品中具有重要的价值。这些化合物的高效α-C─H转化为增值衍生物提供了简化的途径，但由于高C─H BDEs和催化剂中毒，带来了实质性的挑战。光化学策略已成为使硫化物α-C(sp3)-H功能化的有力解决方案。本文综述了光使能硫化物α-C─H功能化方法，特别关注氢原子转移（HAT）和电子转移/质子转移（ET/PT）机制。

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Photo-enabled α-C(sp³)-H Functionalization of Sulfides.

Sulfides hold significant value in fine chemicals and pharmaceuticals. Efficient α-C ─ H transformations of these compounds offer streamlined routes to value-added derivatives but pose substantial challenges due to high C ─ H BDEs and catalyst poisoning. Photochemical strategies have emerged as powerful solutions for enabling α-C(sp³)-H functionalization of sulfides. This review comprehensively surveys photo-enabled sulfide α-C ─ H functionalization methodologies, with particular focus on hydrogen atom transfer (HAT) and electron transfer/proton transfer (ET/PT) mechanisms.

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.