Chemistry - A European Journal最新文献_第10页

Tag-Assisted Liquid-Phase Oligonucleotide Synthesis: Toward a Convergent Approach. 标签辅助液相寡核苷酸合成：趋同方法。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-14 DOI: 10.1002/chem.202500616

Shinnosuke Akahane, Yuki Takahashi, Eimi Morikawa, Masae Sugai, Hideaki Umemoto, Takuya Onaka, Satoshi Ito, Naoto Taki, Yuya Yoshida, Yuto Toichi, Yoshikazu Kitano, Kazuhiro Chiba, Yohei Okada

引用次数: 0

Anion-Mediated Charge-Transfer Assemblies Composed of Resorcin[4]arene and Viologen Salts. 间苯二酚、苯二酚、芳烃和紫素盐组成的阴离子介导的电荷转移组装体。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-13 DOI: 10.1002/chem.202501042

Yuki Konishi, Shinnosuke Horiuchi, Shota Ogura, Kanami Sugiyama, Hikaru Sotome, Mikihiro Hayashi, Masahiro Higashi, Tsukasa Abe, Shuichi Hiraoka

{"title":"Anion-Mediated Charge-Transfer Assemblies Composed of Resorcin[4]arene and Viologen Salts.","authors":"Yuki Konishi, Shinnosuke Horiuchi, Shota Ogura, Kanami Sugiyama, Hikaru Sotome, Mikihiro Hayashi, Masahiro Higashi, Tsukasa Abe, Shuichi Hiraoka","doi":"10.1002/chem.202501042","DOIUrl":"https://doi.org/10.1002/chem.202501042","url":null,"abstract":"Supramolecular assemblies of a concaved aromatic host as electron donor (D) and a cationic heterocyclic guest as electron acceptor (A) are reported. These molecular units were noncovalently bound to afford charge-transfer (CT) complexes in solution and a CT co-crystal, displaying drastic color change from colorless to orange. The binding motif of the assemblies in the solution state was analyzed by NMR spectroscopic analysis and visualized by X-ray crystallographic analysis. Theoretical calculations for the assemblies revealed electronic communication between the D and A fragments, proving their CT characteristics. The CT complexes were stabilized by not only CT and cation-π interactions but also coulomb interaction between cationic acceptor unit and its anion supported by a hydrogen bond with a hydroxy group in the aromatic host, resulted in enhancement of orbital overlapping of the D-A fragments. Owing to the strong D-A interaction in the assemblies, the CT complexes undergo ultrafast charge recombination on a femtosecond timescale after photoexcitation of the CT transition, as confirmed by transient absorption spectroscopy. These results demonstrate that understanding of assembly motif and its noncovalent interactions can lead to create optical materials manupulating electron transition dynamics.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202501042"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chirality Effects in Peptide-Based Dynamic Combinatorial Chemistry. 基于多肽的动态组合化学中的手性效应。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-13 DOI: 10.1002/chem.202501298

Alice Gable, Emmi Pohjolainen, Gerrit Groenhof, Fabien B L Cougnon

引用次数: 0

Functionalization, Fragmentation, and Expansion of cyclo-P₄R₂ Ligands. 环- p4r2配体的功能化、断裂和扩展。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-13 DOI: 10.1002/chem.202501305

Christoph Riesinger, Lisa Zimmermann, Robert Szlosek, Gábor Balázs, Jan Wieneke, Lisa-Marie Orel, Luis Dütsch, Manfred Scheer

{"title":"Functionalization, Fragmentation, and Expansion of cyclo-P4R2 Ligands.","authors":"Christoph Riesinger, Lisa Zimmermann, Robert Szlosek, Gábor Balázs, Jan Wieneke, Lisa-Marie Orel, Luis Dütsch, Manfred Scheer","doi":"10.1002/chem.202501305","DOIUrl":"10.1002/chem.202501305","url":null,"abstract":"In this study, three isolobal complexes of the form [{LnM}(η3-P4R2)]+ ({LnM} = {CpMo(CO)2} (A), {Cp'''Ni} (B), {Cp'''Co}- (C), R = Ph, iPr; Cp''' = 1,2,4-tBu3C5H2) are reacted with nucleophilic carbenes (L). While C does not show any reactivity, the cationic complexes A and B undergo addition reactions. The respective products [CpMo(CO)2(η3-P4R2L)]+ (1a - d) and [Cp'''Ni(η1:1-P4R2L)]+ (3a - d) show different geometries for the L-P3PR2 ligands. Their reactivity towards EtO- results in either a simple addition (for 1) or a complex addition, ring-opening, rearrangement sequence (for 3). Moreover, [Cp'''Ni(η2-IDippPP(OEt)PPiPr2)] (4) could be methylated by the reaction with MeOTf, which affords an iso-tetraphosphine ligand, marking the first example of complete functionalization of a polyphosphorus ligand to a complexed phosphine. Mechanistic studies shed light upon the fundamental principles, which differentiate the influence of the isolobal {CpMo(CO)2}, {Cp'''Ni}, and {Cp'''Co}- transition metal units. Lastly, 3a-d were chosen as model substrates for further nucleophilic functionalization. In this regard, 3 reacts with [CN]- in a [3+1] fragmentation reaction affording the dimerized species [{Cp'''Ni}2(μ,η1:1:1:1-cyclo-P4(PR2)2)] (6a: R = Ph, 6b: R = iPr) together with IDippP-CN. In contrast, the reaction with [ECO]- (E = P, As) led to an extension of the pnictogen framework yielding [Cp'''Ni(η1:1-EP4Ph2IDipp)] (8a: E = P, 8b: E = As).","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202501305"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Organelle-Targeted Fluorescent Probe for Lipid Droplets and Endoplasmic Reticulum Using Bay-Region Substituted Perylene Diimides. 使用海湾区取代苝二亚胺的脂滴和内质网双细胞器靶向荧光探针。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-13 DOI: 10.1002/chem.202500772

Jinping Liu, Xiaoyu Bu, Zikang Yang, Linshuai Yang, Qi Ai, Baoxiang Gao

引用次数: 0

Bifunctional Chiral ImPy-Carbene Ligands. H-Bonding Controlled Reactivity and Enantioselectivity in Au(I)-Catalysis. 邀请您为化学做出贡献。欧元。J.双功能手性吲哚卡宾配体。氢键控制Au(I)-催化反应活性和对映体选择性。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-13 DOI: 10.1002/chem.202501259

Lukas Enders, Riccardo Mobili, Louis Fensterbank, Juho Helaja, Virginie Mouriès-Mansuy

引用次数: 0

Matrix Isolation and Solvation of the Benzonitrile Radical Anion. 苯腈自由基阴离子的基质分离与溶剂化。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-13 DOI: 10.1002/chem.202501150

Shubhra Sarkar, Ankit Somani, Wolfram Sander

{"title":"Matrix Isolation and Solvation of the Benzonitrile Radical Anion.","authors":"Shubhra Sarkar, Ankit Somani, Wolfram Sander","doi":"10.1002/chem.202501150","DOIUrl":"https://doi.org/10.1002/chem.202501150","url":null,"abstract":"Solvated electrons, one of the strongest reducing agents, exhibit short lifetimes in the range of pico- to milliseconds when generated photochemically or by radiolysis in solution. In contrast, solvated electrons produced using sodium metal in liquid ammonia are stable for days and have long been used in synthetic chemistry. Using sodium atoms as an electron source, we were able to trap solvated electrons in low-density amorphous (LDA) water ice matrices with lifetimes of several days and use these electrons as reducing reagent. In LDA matrices doped with benzonitrile 1 these electrons react with 1 to form the benzonitrile radical anion 2. In argon matrices, in the absence of water, only small amounts of 2 were observed after deposition, and most of the sodium and 1 remained unreacted. The yield of radical anion 2 is significantly higher in amorphous water ice than in solid argon. The photoexcitation of radical anion 2 in both argon and LDA water ice matrices resulted in a reversal of the electron transfer under back formation of benzonitrile 1. Annealing of argon matrices doped with small amounts of water containing 2 resulted in the formation of 1:1 and 2:1 hydrogen-bonded complexes between water and radical anion 2.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202501150"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Detergent Chemistry and Handling Support Membrane Protein Analysis Including Lipid Interactions. 洗涤剂化学和处理支持膜蛋白分析包括脂质相互作用的最新进展。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-13 DOI: 10.1002/chem.202501549

Katharina Alker, Jan-Simon Behnke, Leonhard Hagen Urner

{"title":"Recent Advances in Detergent Chemistry and Handling Support Membrane Protein Analysis Including Lipid Interactions.","authors":"Katharina Alker, Jan-Simon Behnke, Leonhard Hagen Urner","doi":"10.1002/chem.202501549","DOIUrl":"https://doi.org/10.1002/chem.202501549","url":null,"abstract":"Non-ionic detergents are key reagents for the characterization of membrane protein drug targets. Suitable detergents are commonly identified by trial and error, which leads to failed preparations and raising costs. Recent findings suggest that not only the chemistry of detergents but also the strategy with which detergents and proteins are brought together impact the successes of investigations. To facilitate the future development of non-ionic detergents in membrane protein research, herein, we review chemical design concepts and detergent exchange strategies for a successful integration of detergents into the analysis of challenging membrane protein complexes. Our overview reveals exciting opportunities to tackle existing challenges, including the stabilization of G-protein coupled receptors, the development of fluorinated detergents for studying protein-lipid binding, top-down design of detergents, and hybrid detergents for the identification of non-canonical lipid associations to proteins with relevance to antibiotic research. Our review will facilitate the development of chemical tools for the biophysical characterization of membrane proteins and support the discovery of biological findings in the future.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202501549"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Flexible, Perfluorinated Analogue of Aluminum Fumarate Metal-Organic Framework. 富马酸铝金属-有机骨架的柔性全氟类似物。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-13 DOI: 10.1002/chem.202500130

Virginia Guiotto, Maria Sole Notari, Diletta Morelli Venturi, Alberto Ricchebuono, Melissa Castagnoli, Christoph Meier, Francesca Nardelli, Lucia Calucci, Matteo Signorile, Marco Taddei, Valentina Crocella', Ferdinando Costantino

{"title":"A Flexible, Perfluorinated Analogue of Aluminum Fumarate Metal-Organic Framework.","authors":"Virginia Guiotto, Maria Sole Notari, Diletta Morelli Venturi, Alberto Ricchebuono, Melissa Castagnoli, Christoph Meier, Francesca Nardelli, Lucia Calucci, Matteo Signorile, Marco Taddei, Valentina Crocella', Ferdinando Costantino","doi":"10.1002/chem.202500130","DOIUrl":"https://doi.org/10.1002/chem.202500130","url":null,"abstract":"Herein we report the synthesis of Al-TFS, a novel aluminum metal-organic framework (MOF) based on tetrafluorosuccinic acid (H2TFS), of formula Al(OH)(TFS)·1.5H2O, introducing a new member to the family of perfluorinated MOFs. The structure of the MOF, solved ab-initio from laboratory powder X-ray diffraction data, displays structural analogies with that of the commercially available Al-fumarate (Basolite A520). The structure is composed of 1D infinite OH-bridged Al octahedra chains connected by the dicarboxylic linkers, designing rhombic channels decorated by fluorine atoms. Upon water removal, the MOF undergoes a phase transition leading to a moderate expansion of the unit cell. Volumetric analysis revealed the presence of ultra-micropores with a size lower than 4 Å. Gas sorption measurements demonstrated for Al-TFS a slightly higher CO2 selectivity compared to N2 and CH4 than the Al-fumarate analogue, with peculiar shapes of the isotherms suggesting a dynamic response of the framework to CO2 adsorption. Using different complementary techniques (in situ infrared spectroscopy, powder X-ray diffraction, solid-state nuclear magnetic resonance spectroscopy, gas/vapor sorption), and density functional theory simulations, the flexibility of the new MOF was disclosed, highlighting the significant impact of fluorination in tailoring materials with structural flexibility and peculiar adsorption properties.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202500130"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chirality in Transition Metal Dichalcogenide Nanostructures. 过渡金属二硫族化合物纳米结构的手性。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-13 DOI: 10.1002/chem.202404765

Lorenzo Branzi, Joseph Martyn, Lucy Fitzsimmons, Yurii K Gun'ko

{"title":"Chirality in Transition Metal Dichalcogenide Nanostructures.","authors":"Lorenzo Branzi, Joseph Martyn, Lucy Fitzsimmons, Yurii K Gun'ko","doi":"10.1002/chem.202404765","DOIUrl":"10.1002/chem.202404765","url":null,"abstract":"The fascinating properties introduced by the breaking of mirror symmetry have recently motivated a rising interest in chirality in nanomaterials. In particular, transition metal (TM) dichalcogenides (TMDs) are a wide group of technologically relevant 2D layered materials where recent efforts in the introduction of chirality have shown promising results, attracting great attention for future studies and potential applications. This review article is focused on the development of chirality in TM dichalcogenide nanostructures, dealing with the synthetic strategies that have been adopted to produce chiral TMDs both via solution-phase and vapor-phase syntheses along with the characterization of their chiroptical properties. A broad range of examples, including a variety of nanostructures such as 0D quantum dots (QDs), 1D nanotubes, 2D flakes, and more complex 3D nanostructures as well as different origins of chirality are considered. Critical analysis of potential pitfalls in the assessment of the materials' chirality are discussed. A broad range of exciting properties and applications associated with the materials' chirality, including: nanomedicine, enantioselective catalysis, spin-dependent electrocatalysis, spintronics, and nonlinear optics, are also presented in the review.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202404765"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0