Chemistry - A European Journal最新文献_第10页

Rapid Stereochemical Analysis of Glycosylations in Flow by Ion Mobility Spectrometry.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-20 DOI: 10.1002/chem.202500311

Jakob B Wolf, Martin Zühlke, Dominik Weh, Marlene C S Dal Colle, Christian Thoben, Toralf Beitz, Klaus Bienert, Dario Cambié, Eric T Sletten, Martina Delbianco, Stefan Zimmermann, Peter H Seeberger

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Cover Feature: Tetrabutylammonium Chlorite as an Efficient Oxidant for Controlled Oxidation of Sulfides to Sulfoxides (Chem. Eur. J. 17/2025)

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-20 DOI: 10.1002/chem.202581702

Yuki Itabashi, Shuto Ogata, Yusuke Shimada, Minato Kondo, Nagatoshi Nishiwaki, Tsuyoshi Inoue, Haruyasu Asahara, Kei Ohkubo

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Cover Feature: Towards White Light Emission Through Metal-to-Metal Charge Transfer (MMCT) Effect in Bi3+ Activated Ca2YTi2-mZrmGa3O12 (0≤m≤2) Garnets (Chem. Eur. J. 17/2025)

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-20 DOI: 10.1002/chem.202581703

Gurusamy Sivakumar, Akkarakkaran Thayyil Muhammed Munthasir, Prof. Dr. Pakkirisamy Thilagar, Prof. Dr. Srinivasan Natarajan

{"title":"Cover Feature: Towards White Light Emission Through Metal-to-Metal Charge Transfer (MMCT) Effect in Bi3+ Activated Ca2YTi2-mZrmGa3O12 (0≤m≤2) Garnets (Chem. Eur. J. 17/2025)","authors":"Gurusamy Sivakumar, Akkarakkaran Thayyil Muhammed Munthasir, Prof. Dr. Pakkirisamy Thilagar, Prof. Dr. Srinivasan Natarajan","doi":"10.1002/chem.202581703","DOIUrl":"https://doi.org/10.1002/chem.202581703","url":null,"abstract":"The emission behaviour of Bi3+ was explored in two different hosts, Ca2YTi2Ga3O12 (CYT:Bi) and Ca2YZr2Ga3O12: Bi3+ (CYTZ:Bi). A broad emission in the yellow–orange region in the former with a maximum at 552 nm was attributed to Bi3+–Ti4+ MMCT transitions. In the latter, the Bi3+ ions were found to emit in the violet region (λem=395 nm) due to the 3P0,1→1S0 transition. After suitable modification, the compounds CYT:Bi and CYTZ:Bi emit white light. More information can be found in the Research Article by P. Thilagar, S. Natarajan and co-workers (DOI: 10.1002/chem.202404016).\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>\u0000 ","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":"31 17","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/chem.202581703","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Mediated Electrochemical Oxidation of Nucleosides to Their 5'-Carboxylic Acid Derivatives. 介导核苷电化学氧化成 5'- 羧酸衍生物。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-20 DOI: 10.1002/chem.202500713

Dylan J Abrams, Mathew R Johnson, Caitlin R Lacker, Tehshik P Yoon, Joseph R Martinelli, Shannon S Stahl

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Synthesis of Heteroleptic Amidinato Calcium Halides via the In-Situ Grignard Addition Method (iGAM) Complementing the Metalation of Amidines.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-20 DOI: 10.1002/chem.202500210

Simon Sengupta, Maximillian Broek, Phil Köhler, Matthias Westerhausen

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Tethered Enantiopure Boramidines for Advanced Chiroptical Studies.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-19 DOI: 10.1002/chem.202500490

Nidal Saleh, Valerio Zullo, Estefanía Sucre-Rosales, Lorenzo Arrico, Francesco Zinna, Gennaro Pescitelli, Céline Besnard, Eric Vauthey, Jérôme Lacour

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Chiral Porous Organic Polymers (CPOPs): Design, Synthesis and Applications in Asymmetric Catalysis.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-19 DOI: 10.1002/chem.202404525

Keshaba Nanda Parida, Chetna Yadav, Swati Jindal, Parag Tamuly, Yashwant D Vankar, Jarugu Narasimha Moorthy

{"title":"Chiral Porous Organic Polymers (CPOPs): Design, Synthesis and Applications in Asymmetric Catalysis.","authors":"Keshaba Nanda Parida, Chetna Yadav, Swati Jindal, Parag Tamuly, Yashwant D Vankar, Jarugu Narasimha Moorthy","doi":"10.1002/chem.202404525","DOIUrl":"https://doi.org/10.1002/chem.202404525","url":null,"abstract":"Since the recognition of the area of asymmetric synthesis in 2000, there has been a tremendous focus on the development of heterogeneous catalysts for asymmetric synthesis. Porous organic polymers (POPs) have emerged in recent years as inextricable materials of high physicochemical and hydrolytic stabilities, permitting infinite possibilities to modulate and tune reactivity, engineer porosity, regulate spatial environments and pore attributes, and manoeuver material transport. With a diligent design of building blocks and the exploitation of organic reactions judiciously, the synthesis of POPs with BET surface areas of the order of a few thousand cm3/g has been demonstrated. The incorporation of reactive functional groups and chiral centres into the porous matrices of polymers offers opportunities to conduct asymmetric synthesis. Very high enantioselectivities of the order of 99% ee have been exemplified in the reactions mediated by chiral POPs (CPOPs). The design-driven tunability of POPs allows the development of catalytic materials for targeted applications in a tailor-made fashion. This review, while placing the development of chiral materials for asymmetric synthesis in the right perspective, delves into different design principles to pave the way for continued research on futuristic CPOP materials by a creative design, limited by one's imagination, for heretofore unprecedented results.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202404525"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioorthogonal Functionalization in the Minor Groove of DNA: Inverse-Electron Demand Diels Alder Reactions with Cyclopropenyl and Heptenoyl Protected 2-Amino-2'-deoxyadenosine as Target Site.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-19 DOI: 10.1002/chem.202500529

Zhenqiang Xia, Dasharath Kondhare, Sushma Deshmukh, Somnath Chandankar, Peter Leonard

{"title":"Bioorthogonal Functionalization in the Minor Groove of DNA: Inverse-Electron Demand Diels Alder Reactions with Cyclopropenyl and Heptenoyl Protected 2-Amino-2'-deoxyadenosine as Target Site.","authors":"Zhenqiang Xia, Dasharath Kondhare, Sushma Deshmukh, Somnath Chandankar, Peter Leonard","doi":"10.1002/chem.202500529","DOIUrl":"https://doi.org/10.1002/chem.202500529","url":null,"abstract":"Bioorthogonal functionalization in the minor groove of DNA with protected 2-amino-2'-deoxyadenosine (2-amino-dA, 1) as target site is described. Cyclopropene and heptene as part of 2-aminoacyl protecting groups served as dienophiles in inverse-electron demand Diels-Alder (iEDDA) reactions with 3,6-dipyridyl-1,2,4,5-tetrazine as diene. For the purpose, bis-protection of 1 with cyclopropenyl and heptenoyl groups was conducted. Selective removal of the 6-amino protecting groups gave mono-protected 1. 2-Amino-dA pyridazine conjugates were accessed by iEDDA cycloaddition with tetrazine. Second order rate constants disclosed faster reaction kinetics for cyclopropenyl than for heptenoyl 2-amino-dA. To access protected oligonucleotides, phosphoramidites prepared from bis-protected 2-amino-dA were used in standard solid-phase synthesis. 2-Amino protecting groups were retained using mild deprotection conditions. Hybridization experiments disclosed increased duplex stability when protected 2-amino-dA-dT pairs replaced 1-dT pairs. Mismatch discrimination of cyclopropenyl and heptenoyl 2-amino-dA was superior to 2-amino-dA. iEDDA reactions on protected oligonucleotides furnished oligonucleotide pyridazine conjugates. In base pairs with dT, 2-amino-dA pyridazine conjugates connected by a short rigid cyclopropenyl ring led to reduced thermal stability, whereas pyridazine conjugates attached by a long flexible linker retained duplex stability. The findings of this investigation pave the way for functionalization and labelling in the minor groove of DNA using copper free iEDDA cycloaddition.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202500529"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MXene Loaded with Cu(2-x)Se Nanozyme for Nanocatalytic Tumor Therapy.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-19 DOI: 10.1002/chem.202500574

Mengtian Lu, Tianye Zhang, Yue Yang, Xin Lin, Jin Huang, Yuan Sun, Tiedong Sun

{"title":"MXene Loaded with Cu(2-x)Se Nanozyme for Nanocatalytic Tumor Therapy.","authors":"Mengtian Lu, Tianye Zhang, Yue Yang, Xin Lin, Jin Huang, Yuan Sun, Tiedong Sun","doi":"10.1002/chem.202500574","DOIUrl":"https://doi.org/10.1002/chem.202500574","url":null,"abstract":"Traditional tumor treatments have certain limitations which have serious negative effects, such as the difficulty in cutting out tumors, the damage to normal tissues, and complications. Ordinary nanozymes generally have low catalytic activity and require higher doses for treatment, which can increase the toxicity and side effects. Here, we designed a Cu(2-x)Se-loaded on MXene, which can catalyze the conversion of the overexpressed hydrogen peroxide into O2 and -OH in cancer cells by Cu(2-x)Se with the catalase (CAT)-like activity and peroxidase (POD) activity, which can effectively alleviate the tumor microenvironment (TEM) hypoxia, as well as degrading the overexpressed glutathione (GSH) and killing the tumor cells to a large extent. At the same time, we used Nanozyme-Carrier Interface Modulation (NCIM): by regulating the interface interaction between nanozymesand carrier materials , the catalytic activity of nanozymes and the photothermal performance of the support were optimized. This regulation can be achieved by adjusting the mass ratio of nanozymes to carriers, surface modification, etc. to improve the performance of the composites. Dual enzyme-active nanozymes loaded with MXene provide a way to synergies catalytic and photothermal therapies, which are considered to be promising materials for future development in the field of nanocomposites for disease treatment.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202500574"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation and Fixation of Atmospheric CO₂ through a 1,2,3-Triazole-Based Mesoionic Carbene-Borane Adduct.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-19 DOI: 10.1002/chem.202403942

Maren Neubrand, Jessica Stubbe, Richard Rudolf, Robert R M Walter, Maite Nößler, Biprajit Sarkar

引用次数: 0