Chemistry - A European Journal最新文献_第9页

Models for the Anionic Polymerization of P=C Bonds: Cyclization of n-BuLi-Initiated MesP=CPh2 and Related Phosphaalkenes with H2C=CPh2.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-22 DOI: 10.1002/chem.202500389

Derek P Gates, Tian Zhang, Kurt F Hoffmann, Brian O Patrick

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Fluorine in the Pharmaceutical Industry: FDA-Approved Fluorine-Containing Drugs in 2024. 制药业中的氟：2024 年美国 FDA 批准的含氟药物。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-22 DOI: 10.1002/chem.202500662

Youlong Du, Yeping Bian, Daniel Baecker, Gagan Dhawan, Anas Semghouli, Loránd Kiss, Wei Zhang, Alexander E Sorochinsky, Vadim A Soloshonok, Jianlin Han

{"title":"Fluorine in the Pharmaceutical Industry: FDA-Approved Fluorine-Containing Drugs in 2024.","authors":"Youlong Du, Yeping Bian, Daniel Baecker, Gagan Dhawan, Anas Semghouli, Loránd Kiss, Wei Zhang, Alexander E Sorochinsky, Vadim A Soloshonok, Jianlin Han","doi":"10.1002/chem.202500662","DOIUrl":"https://doi.org/10.1002/chem.202500662","url":null,"abstract":"Fluorine has become an essential element in the development of modern pharmaceuticals, due to its unique chemical properties which can significantly enhance the biological activity, metabolic stability, and lipophilicity of drug molecules. This review explores recent advancements in the synthesis and application of fluorine-containing drugs approved by the US Food and Drug Administration (FDA) in 2024. These novel drugs demonstrate improved efficacy and safety profiles, addressing a range of therapeutic areas including oncology, infectious diseases, metabolic disorders and genetic disorders that affect the adrenal glands. The incorporation of fluorine atoms into drug candidates has facilitated the development of molecules with optimized pharmacokinetic and pharmacodynamic properties, leading to better patient outcomes. The review further discusses the synthetic methodologies employed, the structural characteristics of these drugs, and their clinical implications, providing insights into the ongoing innovation within the pharmaceutical industry driven by fluorine chemistry.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202500662"},"PeriodicalIF":3.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Synthesis and Evaluation of the Photochemical Properties of Heterocyclic Hemiindigos.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-21 DOI: 10.1002/chem.202500803

Ludovic Jean, Aurélie Gernet, Louise-Marie Balivet, Ahmed El Rhaz, Lucas Pagès, Guillaume Laurent, François Maurel

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Interlayer Modification of Crystalline Layered Silicates with Oligodimethylsiloxane.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-21 DOI: 10.1002/chem.202500262

Riho Wakino, Mai Suzuki, Yoshiaki Miyamoto, Masashi Yatomi, Takamichi Matsuno, Atsushi Shimojima

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Organic electrode material based on tris-imidazole ring containing triphenylamine (donor)-anthraquinone (acceptor) for high performance pseudocapacitors.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-21 DOI: 10.1002/chem.202500723

Sudhir D Jagadale, Sidhanath Vishwanath Bhosale

{"title":"Organic electrode material based on tris-imidazole ring containing triphenylamine (donor)-anthraquinone (acceptor) for high performance pseudocapacitors.","authors":"Sudhir D Jagadale, Sidhanath Vishwanath Bhosale","doi":"10.1002/chem.202500723","DOIUrl":"https://doi.org/10.1002/chem.202500723","url":null,"abstract":"To meet the challenges of the energy sector adaptation of novel electrode materials is urgently needed. Pseudocapacitors are electrochemical energy storage devices and are utilized to fulfill the growing demand of the society. In this connection, donor-acceptor commands are attractive alternatives to inorganic materials die to their optoelectronic properties. Herein, a triphenylamine-anthraquinone based donor-acceptor chromophore was developed in electrode materials. As prepared electrode materials based on TPA-IM-AQ on graphite foil (GF) are employed to fabricate a three-electrode supercapacitor (SC) device in 1M H2SO4 electrolyte. At 0.5 A g-1 current density TPA-IM-AQ electrodes based SC can deliver higher specific capacitance (Csp) of 275.72 F g-1 at 0.5 A g-1 current density and at 5 mV s-1 scan rate with Csp of 233.63 F g-1. Moreover, two-electrode symmetric supercapacitor (SSC) exhibited Csp of 91.63 F g-1 at 0.5 A g-1 with energy density as high as 16.49 Wh kg-1 at a power density of 1079.96 W kg-1. The TPA-IM-AQ/GF based device exhibits good Csp retention with 88.40% after 5000 cycles at 3 A g-1. As-fabricated TPA-Im-AQ/GF electrode demonstrated the advantages of utilizing small organic molecule to achieve wider operational potential window and higher specific capacitance.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202500723"},"PeriodicalIF":3.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Looking to the Future: Prospective Life Cycle Assessment of Emerging Technologies.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-20 DOI: 10.1002/chem.202500304

Alessandro Marson, Alberto Benozzi, Alessandro Manzardo

{"title":"Looking to the Future: Prospective Life Cycle Assessment of Emerging Technologies.","authors":"Alessandro Marson, Alberto Benozzi, Alessandro Manzardo","doi":"10.1002/chem.202500304","DOIUrl":"https://doi.org/10.1002/chem.202500304","url":null,"abstract":"Emerging technologies are expected to contribute to sustainable development, but assessing their future environmental impacts compared to current technologies remains challenging. Prospective Life Cycle Assessment (pLCA) provides a systematic approach to evaluating emerging technologies throughout their life cycle and projecting impacts at future industrial scales. This review aims to identify critical aspects of pLCA methodologies and examine their implementation in recent case studies. Key aspects are highlighted: assessment of initial technology maturity, upscaling methods to model data at higher technology readiness levels, and development of future scenarios to contextualize the scaled-up systems. Specific upscaling techniques such as process simulation, engineering calculations and technology learning curves are discussed. Approaches to generating future scenarios in line with integrated assessment models and common socio-economic pathways are also analyzed. An in-depth literature review covering 2021-2024 publications categorizes 79 articles into literature reviews, methodological papers and pLCA case studies. The identified critical issues serve as a benchmark to assess the completeness and robustness of 20 case studies. Notable contributions, limitations and the need for comprehensive guidelines that integrate scenario development with upscaling methods are highlighted. This review provides valuable insights for researchers conducting pLCA studies of emerging technologies and materials.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202500304"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen Bonding-Induced Multicolor and Thermochromic Emissions of Triphenylamines.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-20 DOI: 10.1002/chem.202500643

Xin Zheng, Gang Wang, Lijie Liu, Xiaochuan Li, Puhui Xie, Yongchao Fan, Zhanqi Cao, Caoyuan Niu, Dongjie Tian, Lixia Xie

引用次数: 0

Molecular Recognition and Chiral Discrimination from NMR and Multi-Scale Simulations.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-20 DOI: 10.1002/chem.202404694

Tadeu Luiz Gomes Cabral, João Pedro Brussolo da Silva, Claudio Francisco Tormena, Matthias Stein

{"title":"Molecular Recognition and Chiral Discrimination from NMR and Multi-Scale Simulations.","authors":"Tadeu Luiz Gomes Cabral, João Pedro Brussolo da Silva, Claudio Francisco Tormena, Matthias Stein","doi":"10.1002/chem.202404694","DOIUrl":"10.1002/chem.202404694","url":null,"abstract":"Chiral molecules are particularly interesting to the pharmaceutical and agrochemical sectors due to their chemical and physical properties. Separation and identification of enantiomers are critical for a broad range of compounds, and discriminating stereoisomers in solution remains a key analytical challenge. Nuclear Magnetic Resonance (NMR) with Matrix-Assisted Diffusion-Ordered Spectroscopy (MAD), in the presence of chiral resolving agents, has emerged as a tool to explore these chiral mixtures. However, insight into the intermolecular interactions that lead to chiral recognition is still limited. Here, we combine experimental MAD studies with computational approaches to investigate the enantioselective discrimination of Mandelic Acid (MA) enantiomers using (R)-BINOL and (S)-BINOL. Molecular dynamics simulations explain the differences in diffusion coefficients for heterochiral complexes. Furthermore, quantum mechanical calculations confirmed enantioselective binding preferences due to differences in Gibbs free energies, highlighting the fundamental interactions and structural criteria that explain the NMR shielding and the diffusion trends. This integrated approach bridges experimental and theoretical studies, offering a comprehensive understanding of chiral recognition mechanisms and elucidating the observed heterochiral preference of BINOL for MA enantiomers. Our findings advance the field of chiral analysis and lay a foundation for future developments for identifying stereoisomers and recognition modes underlying enantioselective binding.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202404694"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Slight-Crosslinking: Opening a New Journey for the Intrinsic Elastification of Ferroelectric Polymers.

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-20 DOI: 10.1002/chem.202500247

Qiuyue Hu, Linping Wang, Liang Pan, Ben-Lin Hu

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Front Cover: Transitioning to Green Discovery-Based Catalysis (Chem. Eur. J. 17/2025)

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-03-20 DOI: 10.1002/chem.202581701

Prof. Dr. Rory Waterman

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