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二磷酸伯氨喹抗疟疾药物的批量合成。

IF 3.7 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Chemistry - A European Journal Pub Date : 2025-09-24 DOI:10.1002/chem.202502183
Faith M Akwi, Simthandile Swartbooi, Paul Watts
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引用次数: 0

摘要

报道了一种改进的三步法合成二磷酸伯氨喹的路线。该抗疟疾药物是通过易得的邻苯二胺钾的正烷基化、还原胺化和室温甲基胺水解辅助邻苯二胺的关键中间体去保护得到的，总分离收率为47%。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Batch Synthesis of Primaquine Diphosphate Anti-Malarial Drug.

An improved three-step synthesis route toward Primaquine Diphosphate is reported herein. The anti-malarial drug was obtained via n-alkylation of readily available potassium phthalimide, followed by reductive amination and room temperature methylaminolysis-assisted phthalimido deprotection of the key intermediates to furnish Primaquine Diphosphate in 47% overall isolated yield.

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来源期刊
Chemistry - A European Journal
Chemistry - A European Journal 化学-化学综合
CiteScore
7.90
自引率
4.70%
发文量
1808
审稿时长
1.8 months
期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.
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