Chemistry - A European Journal最新文献_第2页

One-Pot Photoreactions: A Source for Metal-Polymer Nanocomposites. 单锅光反应：金属-聚合物纳米复合材料的来源。

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2025-07-27 DOI: 10.1002/chem.202501539

Mathias Wiech, Max Schmallegger, Sebastian Soritz, Konstantin Knaipp, Mercedes Linares-Moreau, Arwin Samardzic, Daniel Moser, Heinz Amenitsch, Heidrun Gruber-Woelfler, Georg Gescheidt

{"title":"One-Pot Photoreactions: A Source for Metal-Polymer Nanocomposites.","authors":"Mathias Wiech, Max Schmallegger, Sebastian Soritz, Konstantin Knaipp, Mercedes Linares-Moreau, Arwin Samardzic, Daniel Moser, Heinz Amenitsch, Heidrun Gruber-Woelfler, Georg Gescheidt","doi":"10.1002/chem.202501539","DOIUrl":"https://doi.org/10.1002/chem.202501539","url":null,"abstract":"We have developed a one-step, one-pot photo-induced method for synthesizing metal/polymer nanocomposites. This approach utilizes the photolysis of a bis(acyl)phosphane oxide (BAPO) photoinitiator. Two types of radicals are formed. One initiates a radical polymerization while the other acts as a reducing agent in aqueous or alcoholic media. As a result, metal nanoparticles are formed in situ during polymerization and become embedded within the growing polymer matrix. This simultaneous formation and incorporation lead to the direct immobilization of metal centers, yielding stable nanocomposites. In this proof-of-principle study, we established mechanistic details and characterized the composites. We have evaluated their activity in well-established catalytic reactions. Here, Pd composites were used for Suzuki coupling, Cu for alkyne-azide coupling (CuAAC), and Ag for the reduction of 4-nitrophenol. The results confirm that the nanocomposites exhibit catalytic activity. Our methodology offers a versatile and easily tunable platform for the synthesis of nanocomposites. Any monomer amenable to radical polymerization can be employed, and a wide range of metal salts can be reduced via the photo-initiated process. The syntheses are rapid (approximately 10 minutes), require no hazardous solvents or complex reaction conditions, and enable straightforward work-up.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e01539"},"PeriodicalIF":3.7,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Water, Vacuum, and Temperature on Surface Conditions of a Zeolite-based Molecular Sieve. 水、真空和温度对沸石分子筛表面条件的影响。

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2025-07-27 DOI: 10.1002/chem.202501713

Radosław Zaleski, George Evans, Agnieszka Kierys, Mateusz Kochel, Marcin Kuśmierz, Jagoda Urban-Klaehn, Robert Staub, Marek Wiertel

{"title":"Influence of Water, Vacuum, and Temperature on Surface Conditions of a Zeolite-based Molecular Sieve.","authors":"Radosław Zaleski, George Evans, Agnieszka Kierys, Mateusz Kochel, Marcin Kuśmierz, Jagoda Urban-Klaehn, Robert Staub, Marek Wiertel","doi":"10.1002/chem.202501713","DOIUrl":"https://doi.org/10.1002/chem.202501713","url":null,"abstract":"Molecular sieves such as zeolite-based materials are ubiquitous in industrial separation processes. However, there is a significant gap in understanding the surface properties and adsorption mechanisms for commercial zeolites, as most research focuses on pure zeolite powders rather than industrially relevant forms. This work addresses this gap in understanding by employing advanced characterization techniques, including positron annihilation spectroscopy, X-ray diffraction, scanning electron microscopy, X-ray fluorescence spectroscopy, X-ray photoelectron spectroscopy, liquid nitrogen sorption, and Fourier-transform infrared spectroscopy, to investigate the adsorption and desorption behavior of water in commercial zeolite 13X. Our research reveals insights into the pore-filling mechanisms, the impact of material binders on adsorption properties, and the dynamics of hydration and drying processes for zeolites. Monitoring changes on a minute scale allowed the distinction between fast and slow processes leading to sample drying. The identification of positronium bound to Na+ ions indicated that water molecules remain in the vicinity of Na+ ions after air-drying zeolite 13X. These findings highlight the importance of various environmental conditions in restoring zeolite properties to baseline after hydration, with significant implications for optimizing industrial processes. This work sets the direction for further research aimed at developing more efficient and robust separation techniques.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e01713"},"PeriodicalIF":3.7,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Synthesis of NICOL, A Coligand Secreted Protein Mediating Mammalian Male Reproductive Tract Trans-luminal Signaling. 介导哺乳动物雄性生殖道跨腔信号的Coligand分泌蛋白NICOL的化学合成

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-07-26 DOI: 10.1002/chem.202501588

Kenta Nagahama, Toshiki Takei, Shun Ito, Toshifumi Takao, Hironobu Hojo, Daiji Kiyozumi

引用次数: 0

Cover Feature: The Dugganite Structure as a Host for New Colored Compounds and for Oxygen Evolution Studies 封面专题：杜甘花岗岩结构作为新的有色化合物和析氧研究的宿主

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-07-26 DOI: 10.1002/chem.202584103

Indrani. G. Shanmugapriya, Manoj Dey, Mingli Liang, Dipanti Borah, Abhishek Kumar Singh, P. Shiv Halasyamani, Maheswaran Shanmugam, Srinivasan Natarajan

引用次数: 0

Front Cover: Fine-Tuning the Motion of Tetrafluoro-1,4-Benzoquinone within Charge-Transfer Cocrystals Through Variation of the Donor: An Entropic and Enthalpic Point of View 封面：通过供体的变化微调四氟-1,4-苯醌在电荷转移共晶中的运动：一个熵和焓的观点

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-07-26 DOI: 10.1002/chem.202584101

Armando Navarro-Huerta, Martha E. García-Aguilera, Jan Blahut, Erika Bartůňková, Rubén A. Toscano, Mario Rodríguez, Martin Dračínský, Braulio Rodríguez-Molina

引用次数: 0

Cover Feature: Pd[B(S2O7)2]2 and Pd[B(SO4) (S2O7)]2: Two Borosulfates with Pd2+ in Octahedral and One with Pd2+ in Square Planar Oxygen Coordination 封面特征：Pd[B(S2O7)2]2和Pd[B(SO4) (S2O7)]2：两种具有八面体Pd2+的硼硫酸盐和一种具有方形平面氧配位的Pd2+

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-07-26 DOI: 10.1002/chem.202584102

Stefan Sutorius, David Patrun, Arthur Edelmann, Lars Schumacher, Rainer Pöttgen, Markus Suta, Jörn Bruns

引用次数: 0

Engineering Alloxazines by Boron Coordination and Click Chemistry toward Small-molecule Fluorescent Probes. 硼配位和点击化学在小分子荧光探针中的工程应用。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-07-25 DOI: 10.1002/chem.202501878

Oscar Charpentier, Ambroise Mouhanna, Eleanna Nikolopoulos, Aurélie Guenet, Christophe Gourlaouen, Marine Desage-El Murr

引用次数: 0

Mechanical Strain-Controlled Aromaticity in Cyclo[n]Carbons. 环[n]碳的机械应变控制芳香性。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-07-25 DOI: 10.1002/chem.202501598

O A Stasyuk, C Curutchet, A J Stasyuk

{"title":"Mechanical Strain-Controlled Aromaticity in Cyclo[n]Carbons.","authors":"O A Stasyuk, C Curutchet, A J Stasyuk","doi":"10.1002/chem.202501598","DOIUrl":"https://doi.org/10.1002/chem.202501598","url":null,"abstract":"Cyclocarbons have unique electronic and mechanical properties, but their extreme reactivity makes experimental studies and practical applications highly challenging. In this work, we use molecular modeling to investigate how mechanical strain, including uniaxial tension and radial contraction/expansion, affects the aromaticity of C16 and C18 cyclocarbons. Aromaticity was evaluated using magnetic (NICS, GIMIC) and electronic (π-EDDB, AV1245) indices to provide a comprehensive assessment. Our results show that uniaxial tension slightly reduces the (anti)aromaticity of both cyclocarbons, with C16 becoming less antiaromatic and C18 less aromatic. Radial expansion leads to almost complete loss of aromaticity, regardless of the initial electronic nature of the cyclocarbon. In turn, radial contraction appears to be an effective approach to enhance electronic delocalization in cyclocarbons, with a particularly notable effect for C18. One of the most significant findings is that an 8% radial contraction transforms moderately aromatic C18 into a highly aromatic system with fully equalized bond lengths, offering a potential strategy for designing more stable cyclocarbon systems within mechanically strained architectures.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e01598"},"PeriodicalIF":3.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Layer Sliding-Induced Fluorescence Changes in a Flexible Hydrogen-Bonded Organic Framework. 柔性氢键有机骨架中层滑动诱导的荧光变化。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-07-25 DOI: 10.1002/chem.202502078

Taito Hashimoto, Mario de la Hoz Tomás, Ryusei Oketani, Boiko Cohen, Abderrazzak Douhal, Ichiro Hisaki

{"title":"Layer Sliding-Induced Fluorescence Changes in a Flexible Hydrogen-Bonded Organic Framework.","authors":"Taito Hashimoto, Mario de la Hoz Tomás, Ryusei Oketani, Boiko Cohen, Abderrazzak Douhal, Ichiro Hisaki","doi":"10.1002/chem.202502078","DOIUrl":"https://doi.org/10.1002/chem.202502078","url":null,"abstract":"Flexible hydrogen-bonded organic frameworks (HOFs) capable of changing their fluorescence properties upon structural transformation have gained much attention, while their design strategies have not been established. Herein, we demonstrate that sliding of the robust hydrogen-bonded 2D layers can induce dynamic emission color changes of HOFs. Layered HOF CP-tBPy-1, which is composed of tert-butylpyrene derivative with four carboxyphenyl groups (CP-tBPy), transformed to another crystalline form, CP-tBPy-2, upon release of guest solvent molecules. Single-crystal X-ray diffraction analysis revealed that the sliding of the layers changed the pyrene cores from monomeric to dimeric species, giving rise to fluorescence color changes from blue to green. Fluorescence spectroscopy and single-crystals microscopy disclosed details of the photobehaviors of these HOFs. These results are the first example of fluorescence changes of HOFs due to sliding of hydrogen-bonded 2D network layers, providing a new design strategy to construct functional fluorescent porous materials.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e02078"},"PeriodicalIF":3.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation of S1PR1 by Ponesimod for Multiple Sclerosis Therapy: Uncovering MAPK and PI3K Pathway Mechanisms and Repurposing Potential. Ponesimod激活S1PR1用于多发性硬化治疗：揭示MAPK和PI3K通路机制和再利用潜力

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-07-25 DOI: 10.1002/chem.202404742

Yue Ran, Xiao-Nan Niu, Ying-Jie Wang, Wei-Hai Xu, Jian-Hua Liang, Yan Xu, Shi-Lu Chen, Ming-Jia Yu

{"title":"Activation of S1PR1 by Ponesimod for Multiple Sclerosis Therapy: Uncovering MAPK and PI3K Pathway Mechanisms and Repurposing Potential.","authors":"Yue Ran, Xiao-Nan Niu, Ying-Jie Wang, Wei-Hai Xu, Jian-Hua Liang, Yan Xu, Shi-Lu Chen, Ming-Jia Yu","doi":"10.1002/chem.202404742","DOIUrl":"https://doi.org/10.1002/chem.202404742","url":null,"abstract":"Multiple sclerosis (MS), affecting over 2 million people globally, primarily causes neurological disability in individuals under 40. This autoimmune disorder involves the immune system attacking the myelin sheath in the central nervous system. Sphingosine-1-phosphate receptor 1 (S1PR1) is a promising therapeutic target, with approved drugs like ponesimod acting as S1PR1 agonists. However, the exact mechanism of ponesimod's action on S1PR1 and its therapeutic effects in MS remains unclear. Our study, combining metadynamics, single-cell transcriptomics, and drug repurposing, shows that ponesimod binds to S1PR1, causing the W2696.48 amino acid to flip downward. This flip weakens interactions within the phosphorylation-independent binding (PIF) motif while maintaining the N3077.49-F2656.44 interaction, activating Gi signaling. The downstream effects primarily involve the MAPK/ERK and PI3K-Akt pathways, which inhibit lymphocyte migration to lymph nodes, a crucial factor in ponesimod's clinical efficacy. Single-cell transcriptomic analysis further elucidates the regulatory network and pathways modulated by ponesimod in MS. Notably, due to potential hepatotoxicity, we identified valproic acid (VPA) as a potential adjunct therapy through drug repurposing. VPA reduces hepatotoxicity and demonstrates efficacy in treating MS in animal studies. This research provides valuable insights into ponesimod's mechanism in MS treatment and highlights the potential of drug repurposing to improve MS therapy.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e04742"},"PeriodicalIF":3.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0