International journal of pediatric otorhinolaryngology最新文献

{"title":"The use of intralesional & systemic bevacizumab in severe recurrent respiratory papillomatosis: A case report","authors":"Róisín Kay ,&nbsp;Hannah Griffiths ,&nbsp;Mihiar Atfeh","doi":"10.1016/j.ijporl.2025.112683","DOIUrl":"10.1016/j.ijporl.2025.112683","url":null,"abstract":"<div><h3>Introduction</h3><div>Recurrent respiratory papillomatosis (RRP) can represent a significant clinical challenge in the world of paediatric airway disease. The disease's severity and progression may vary and therefore necessitate a constantly evolving and evidence-based approach. The most recently pioneered arm of managing RRP is the use of VEGF monoclonal antibody, bevacizumab. This is a challenging case of aggressive paediatric RRP that has required the use of all available treatment modalities.</div></div><div><h3>The patient</h3><div>A 10-year-old girl, with significant medical and neurological history, was diagnosed with aggressive airway-obstructing RRP at 2 years of age. Over the years, she has undergone various RRP treatments, which have failed to control her disease progression.</div></div><div><h3>The primary diagnoses interventions and outcomes</h3><div>Following failure of traditional management adjuncts, and due to the increasing frequency and need for surgical debridement, an evidence-based decision was made to administer bevacizumab. This was administered locally, and resulted in temporary improvement. Therefore, systemic bevacizumab was eventually sought with excellent outcomes within the first year.</div></div><div><h3>Conclusion</h3><div>Aggressive RRP, particularly in the presence of other comorbidities, presented a management dilemma in this case. The aggressive nature of the disease necessitated out-of-box thinking, seeking evidence from the literature, and a consultation with national experts on the application of alternative treatment options such as intralesional and, subsequently, systemic bevacizumab. The latter has so far produced a yearlong excellent control of the condition. The article discusses suggestions for multicentre research into this treatment modality, and for the standardisation its administration protocols in adults and children.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"200 ","pages":"Article 112683"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145810063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of musical perception and emotional development in children with cochlear implants","authors":"Artuğ Demi̇rel ,&nbsp;Ilda Tanrisever Pehli̇van ,&nbsp;Ozgur Surmelioglu ,&nbsp;Caglar Eker ,&nbsp;Elvan Onan ,&nbsp;Muhammed Dagkiran ,&nbsp;Suleyman Ozdemi̇r ,&nbsp;Mustafa Mete Kıroglu","doi":"10.1016/j.ijporl.2025.112685","DOIUrl":"10.1016/j.ijporl.2025.112685","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"200 ","pages":"Article 112685"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145787239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized control trial comparing treatment outcomes of monopolar cautery versus BiZact™ total tonsillectomy in children","authors":"Taylor Leavitt ,&nbsp;Jeffrey A. Carter ,&nbsp;Anna H. Messner ,&nbsp;Yi-Chun Liu ,&nbsp;Sonal V. Saraiya ,&nbsp;Matthew S. Sitton ,&nbsp;Kathleen Hosek ,&nbsp;Ugochukwu Madueke ,&nbsp;Paulina M. Powell ,&nbsp;Ronald J. Vilela","doi":"10.1016/j.ijporl.2025.112689","DOIUrl":"10.1016/j.ijporl.2025.112689","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"200 ","pages":"Article 112689"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145819106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-reactive protein as a predictor of intracranial complications in paediatric acute Mastoiditis: Findings from a 25-year retrospective study","authors":"Jeanette Hess-Erga ,&nbsp;Gro Sævik Dyrhovden ,&nbsp;Ingvild Øvstebø Engesæter ,&nbsp;Kathrin Skorpa Nilsen ,&nbsp;Frederik Kragerud Goplen ,&nbsp;Ruben Dyrhovden ,&nbsp;Jan Erik Berge","doi":"10.1016/j.ijporl.2025.112674","DOIUrl":"10.1016/j.ijporl.2025.112674","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"200 ","pages":"Article 112674"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective evaluation of hearing aids fitting efficacy in pediatric populations using cortical auditory evoked potentials","authors":"Qianqian Guo ,&nbsp;Chao Meng ,&nbsp;Jing Lyu ,&nbsp;Yuling Li ,&nbsp;Xueqing Chen","doi":"10.1016/j.ijporl.2025.112651","DOIUrl":"10.1016/j.ijporl.2025.112651","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the relationships between cortical auditory evoked potentials (CAEPs), behavioral aided hearing thresholds, and functional auditory performance to validate CAEPs as an objective tool for assessing hearing aids fitting and to develop an integrated test battery for children with hearing loss.</div></div><div><h3>Methods</h3><div>Thirty children (aged 24–60 months) with bilateral sensorineural hearing loss were participated in this study. CAEPs were recorded in sound field using the HEARLab™ system in response to three speech stimuli (/m/,/g/,/t/) presented at 55, 65, and 75 dB SPL. Participants were categorized into Group A (CAEPs present for all stimuli at 55 dB SPL, n = 12) and Group B (absent waveforms at 55 dB SPL, n = 18). Aided sound-field thresholds were behaviorally assessed, and functional auditory performance was evaluated using the validated Mandarin version of the Parents' Evaluation of Aural/Oral Performance of Children (PEACH) scale.</div></div><div><h3>Results</h3><div>Group A demonstrated aided thresholds within the speech banana across all tested frequencies, whereas Group B exhibited significantly higher thresholds. CAEPs detectability was strongly dependent on sensation level (SL), with waveforms consistently detected above 10 dB SL. P1 latency decreased significantly with increasing SL (β = −0.513 ms/dB, <em>p</em> &lt; 0.001), while P1 amplitude increased (β = 2.827 μV/dB, <em>p</em> &lt; 0.001). A strong positive correlation was observed between CAEP scores and PEACH questionnaire results (r = 0.884, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>CAEPs provide an objective and frequency-specific neurophysiological method for verifying HAs fitting outcomes in children who are unable to cooperate with conventional subjective testing.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"200 ","pages":"Article 112651"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145654336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide analysis of hospital-level disparities in peritonsillar abscess management","authors":"Veronica K. Han ,&nbsp;Hardeep S. Tiwana ,&nbsp;Dean G. Kennedy ,&nbsp;Bryan Wang ,&nbsp;Shivani K. Patel ,&nbsp;Frances R. Lara ,&nbsp;Jessica R. Levi","doi":"10.1016/j.ijporl.2025.112688","DOIUrl":"10.1016/j.ijporl.2025.112688","url":null,"abstract":"<div><h3>Objective</h3><div>Peritonsillar abscess (PTA) is a common deep neck infection that can cause severe complications if untreated. While management strategies are well established, limited evidence exists on how hospital type, safety-net (SNH) versus non–safety-net hospitals (non-SNHs), affects treatment, readmissions, and outcomes. This study evaluated national PTA outcomes with a focus on hospital type and patient demographics.</div></div><div><h3>Methods</h3><div>We performed a retrospective cohort study using the 2020 HCUP National Readmission Database to identify PTA admissions and 30-day readmissions. Demographic, clinical, and hospital-level factors were analyzed, including length of stay (LOS) and charges. Comparisons were made between SNHs and non-SNHs.</div></div><div><h3>Results</h3><div>Among 3915 admissions, the overall 30-day readmission rate was 4.9 % (n = 190). Patients under 25 years comprised 41.5 % of admissions and had higher readmission rates (5.2 %) compared with older patients. Readmissions did not differ by sex, insurance, or income quartile. Non-SNHs treated higher PTA volumes, while SNHs cared for more Medicaid and lower-income patients. Outcomes were similar across hospital types: mean LOS was slightly longer at SNHs (2.6 vs. 2.4 days, p = 0.04), and mean charges were higher at non-SNHs ($26,012 vs. $22,475, p &lt; 0.01). Readmission rates were comparable (SNH 4.8 % vs. non-SNH 5.0 %, p = 0.71).</div></div><div><h3>Conclusion</h3><div>PTA management is consistent across hospital types, with no significant outcome differences between SNHs and non-SNHs. Younger patients had higher readmission risk, and cost disparities between hospital types highlight the need for further research on resource utilization and the role of tonsillectomy.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"200 ","pages":"Article 112688"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145787236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic dilemmas in laryngeal clefts: Are treatment decisions influenced by bias? A two-stage study","authors":"Goli Golpayegani,&nbsp;Eric Levi,&nbsp;Ramanan Daniel","doi":"10.1016/j.ijporl.2025.112678","DOIUrl":"10.1016/j.ijporl.2025.112678","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"200 ","pages":"Article 112678"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Otolaryngologic evaluation and management of nasal chondromesenchymal hamartoma","authors":"John W. Hunsicker ,&nbsp;Megan Ballard ,&nbsp;Ashoke Khanwalkar ,&nbsp;Todd M. Wine ,&nbsp;Mark A. Lovell ,&nbsp;Alexandra G. Suttman ,&nbsp;Kami Wolfe Schneider ,&nbsp;Kenny H. Chan","doi":"10.1016/j.ijporl.2025.112657","DOIUrl":"10.1016/j.ijporl.2025.112657","url":null,"abstract":"<div><h3>Introduction</h3><div>Nasal chondromesenchymal hamartoma (NCMH) is a rare benign tumor of the nasal cavity and paranasal sinuses. Its clinical relevance has increased following the discovery of its association with DICER1 syndrome—a genetic condition predisposing individuals to multiple neoplasms. These two cases highlight important clinical extremes of this disease entity and offer practical evaluation and management recommendations for practicing otolaryngologists.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted from 1999 to 2025 at a single institution. The report includes two female teenagers presented at ages 13 and 17 years, respectively, diagnosed with NCMH—one with and one without DICER1 syndrome. Key outcomes included recurrence rates, anatomical spread, genetic testing results (including evaluation for <em>DICER1</em> variants), and disease-status at follow-up. A thorough literature review on NCMH and DICER1 syndrome was conducted to provide the reader with management recommendations.</div></div><div><h3>Results</h3><div><ul><li><span>•</span><span><div><strong>Case 1</strong><strong>.</strong> A 13-year-old female with NCMH in the left ethmoid sinus underwent complete surgical resection and had no pathogenic <em>DICER1</em> variants detected. No recurrence was observed after 3 years.</div></span></li><li><span>•</span><span><div><strong>Case 2</strong><strong>.</strong> A 17-year-old female with DICER1 syndrome experienced multiple recurrences of NCMH after initial diagnosis, requiring five surgical resections. She had bilateral disease and skull base involvement. She remains disease-free one year after her last surgery.</div></span></li></ul></div></div><div><h3>Conclusions</h3><div>Genetic testing for <em>DICER1</em> variants should be standard in all newly diagnosed NCMH cases. Annual nasal endoscopic and imaging follow up is recommended in all individuals with a constitutional or mosaic pathogenic <em>DICER1</em> variant. There is no published guidance for recurrent NCMH at the olfactory groove/cribriform plate region. Conservative local excisions should be pursued for tumor recurrences.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"200 ","pages":"Article 112657"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood eosinophil percentage as a triage signal in pediatric allergic Rhinitis: Data-Driven cut-offs from a public cohort","authors":"Xiaoxiao Huang ,&nbsp;Jun Chen ,&nbsp;Tong Wu ,&nbsp;Chi Wang ,&nbsp;Bo Ning ,&nbsp;Lijuan Yang","doi":"10.1016/j.ijporl.2025.112677","DOIUrl":"10.1016/j.ijporl.2025.112677","url":null,"abstract":"<div><h3>Background</h3><div>Clinicians need simple, clinic-ready rules to sort children with allergic rhinitis (AR) by near-term symptom burden. We examined whether peripheral blood eosinophil percentage (Eos %) yields useable thresholds for first-pass triage.</div></div><div><h3>Methods</h3><div>We performed a cross-sectional secondary analysis of a public pediatric dataset, including children with AR and non-missing Eos % and Total Nasal Symptom Score (TNSS). “High burden” was prespecified as TNSS ≥21 (cohort upper quartile). We estimated ROC/AUC, derived the Youden cut-off with 1000-bootstrap CIs, and identified targeted operating points emphasizing high sensitivity (≥0.80) or high specificity (≥0.80). Clinical utility was assessed using decision curve analysis (DCA) for threshold probabilities 0.15–0.30. Sensitivity analyses varied the TNSS cut-point and stratified by sex.</div></div><div><h3>Results</h3><div>Among 199 children, 26.6 % met the high-burden definition. Eos % discrimination was modest (AUC 0.606; 95 % CI 0.518–0.699). The Youden cut-off was 6.8 % (95 % CI 2.8–9.1), yielding sensitivity 0.53 and specificity 0.68 (accuracy 0.64; PPV 0.37; NPV 0.80). A ∼3.7 % rule achieved sensitivity 0.81/specificity 0.33, whereas an ∼8.5 % rule achieved specificity 0.81/sensitivity 0.32. DCA supported fixed rules in the 6–8 % band compared with treat-all/none for pt = 0.15–0.30. Findings were directionally consistent using TNSS ≥20 or ≥22 and across sex strata (boys: AUC 0.569, optimal 6.8 %; girls: AUC 0.691, optimal 3.1 %).</div></div><div><h3>Conclusions</h3><div>Eosinophil percentage (Eos %) exhibited modest discriminatory ability (AUC 0.606; 95 % CI 0.518–0.699) for triage in pediatric allergic rhinitis. Low thresholds of ∼3–4 % for screening, 6–8 % for balanced triage (optimal ∼6.8 %), and ∼8–9 % for confirmation offered limited utility when combined with symptom assessments. Due to weak performance, CI proximity to 0.5, and false-positive risk (e.g., PPV 0.37 at optimal cutoff), Eos % is inadequate alone and serves only as a weak complementary signal; prospective validation is essential.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"200 ","pages":"Article 112677"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145787238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newborn Hearing Screening to Diagnosis: A Clinical Study of 15,818 Cases","authors":"Yanmin Chen M.M ,&nbsp;Feiwei An PhD","doi":"10.1016/j.ijporl.2025.112701","DOIUrl":"10.1016/j.ijporl.2025.112701","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the epidemiological characteristics, risk factors, and follow-up outcomes of neonatal hearing loss, thereby providing a basis for optimizing screening and intervention strategies.</div></div><div><h3>Methods</h3><div>A total of 15,818 newborns born at Shenzhen Maternity and Child Healthcare Hospital between January and December 2022 were enrolled. Initial screening was conducted using distortion product otoacoustic emissions (DPOAE). Infants who referred underwent rescreening with a combination of DPOAE and automated auditory brainstem response(AABR), and those who failed were referred for comprehensive diagnostic evaluation at 3 months of age, including auditory brainstem response(ABR), auditory steady-state response(ASSR), and acoustic immittance testing. Pass rates and loss-to-follow-up rates at each stage were analyzed, along with the characteristics and risk factors of confirmed hearing loss.</div></div><div><h3>Results</h3><div>Of the cohort, 15,643 newborns completed the initial screening, with a pass rate of 96.71%. Forty-six cases were confirmed with hearing loss, yielding a detection rate of 2.94 per 1,000. The pass rate for the right ear (97.93%) was significantly higher than for the left ear (97.55%) (P &lt; 0.001). Among the diagnosed cases, hearing loss was predominantly unilateral (56.52%), mild-to-moderate in degree (73.91%), and conductive in type (50.00%). The primary risk factors identified were preterm birth (30.43%), low birth weight (17.39%), craniofacial anomalies (15.22%), and hyperbilirubinemia (13.04%). Follow-up and genetic testing were completed for 42 infants. Pathogenic variants in GJB2 or SLC26A4 genes were identified in 4 cases (9.52%). Hearing returned to normal in 10 infants (23.81%), while the hearing status of those with severe-to-profound loss remained stable. A significant difference was observed in the distribution of hearing loss between the initial diagnosis and follow-up (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study found a neonatal hearing loss detection rate consistent with previous reports, observed a higher screening pass rate in the right ear. The hearing loss was predominantly unilateral and mild-to-moderate, with follow-up revealing a dichotomous trend of either spontaneous recovery or persistence. This pattern highlights the necessity of enhancing follow-up management during the critical window between rescreening and diagnosis, and of formulating stratified and individualized intervention and follow-up protocols.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"201 ","pages":"Article 112701"},"PeriodicalIF":1.3,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}