International journal of pediatric otorhinolaryngology最新文献

{"title":"Preclinical assessment of agreement between optical frequency domain imaging and pathology in rabbit subglottic mucosal lesions","authors":"Yuki Komyo ,&nbsp;Yuichiro Tomioka ,&nbsp;Yuichi Okata ,&nbsp;Harunori Miyauchi ,&nbsp;Taichi Nakatani ,&nbsp;Shino Inuzuka ,&nbsp;Tomoo Itoh ,&nbsp;Yuko Bitoh","doi":"10.1016/j.ijporl.2025.112499","DOIUrl":"10.1016/j.ijporl.2025.112499","url":null,"abstract":"<div><h3>Objective</h3><div>The pediatric subglottic airway is susceptible to various pathological conditions, both congenital and acquired. Accurate imaging of subglottic mucosal lesions is essential for appropriate treatments, but existing methods such as bronchoscopy or computed tomography (CT) often lack resolution or objectivity. Optical coherence tomography (OCT) has been used, but the correlation between OCT-based imaging and histopathological findings has not been evaluated. Optical frequency domain imaging (OFDI), a clinical-grade variant of OCT, offers higher resolution and faster acquisition. We aimed to evaluate whether OFDI can safely and clearly visualize subglottic mucosal structures and examine how well the imaging findings correspond to histological features in an animal model.</div></div><div><h3>Methods</h3><div>Twelve rabbits weighing approximately 3 kg were used. Under anesthesia, brush scrubbing was performed to induce mucosal lesions in the subglottic space. The resected larynx was pathologically examined. The primary efficacy endpoints were circumferential visualization of the subglottic space and concordance with pathology in differentiating between the cartilage, mucosa, and lesions. The primary safety endpoints were the absence of mucosal injury and catheter dislodgement during OFDI.</div></div><div><h3>Results</h3><div>Clear images of the subglottic space were obtained, and OFDI clearly distinguished the cartilage from the mucosa and lesions. The interobserver reliability of the OCT assessment was 0.87, and the agreement between OCT and the histological assessment was 0.94. No mucosal hemorrhage or catheterization-induced dehiscence was observed.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that OFDI can be used safely and has a diagnostic performance comparable to that of histological assessment of mucosal lesions in the subglottic space.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"196 ","pages":"Article 112499"},"PeriodicalIF":1.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Speech Perception in noise in adolescents with cochlear implant” [Int. J. Pediatric Otorhinolaryngol. 193 (2025) 112317]","authors":"Letizia Guerzoni ,&nbsp;Chiara Falzone ,&nbsp;Sara Ghiselli ,&nbsp;Maria Nicastri ,&nbsp;Patrizia Mancini ,&nbsp;Enrico Fabrizi ,&nbsp;Domenico Cuda","doi":"10.1016/j.ijporl.2025.112496","DOIUrl":"10.1016/j.ijporl.2025.112496","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"197 ","pages":"Article 112496"},"PeriodicalIF":1.3,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgery for recurrent croup? A new therapeutic tool","authors":"Valeria Godoy,&nbsp;Sahba Sedaghat","doi":"10.1016/j.ijporl.2025.112498","DOIUrl":"10.1016/j.ijporl.2025.112498","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"196 ","pages":"Article 112498"},"PeriodicalIF":1.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stented and non-stented endoscopic techniques in bilateral choanal atresia repair: A systematic review and meta-analysis","authors":"Raisa Chowdhury ,&nbsp;Deema Almutawa ,&nbsp;Nasser K. Almutairi ,&nbsp;Ostap Orishchak ,&nbsp;Hamad Almhanedi ,&nbsp;Marc A. Tewfik ,&nbsp;Sam J. Daniel","doi":"10.1016/j.ijporl.2025.112494","DOIUrl":"10.1016/j.ijporl.2025.112494","url":null,"abstract":"<div><h3>Background</h3><div>Bilateral choanal atresia is a rare congenital obstruction of the posterior nasal apertures that causes severe respiratory distress and feeding difficulties in neonates and infants. While endoscopic surgical repair is the standard of care, the use of postoperative nasal stents remains controversial due to potential complications.</div></div><div><h3>Objectives</h3><div>This systematic review and meta-analysis compared outcomes of stented versus non-stented endoscopic approaches in bilateral choanal atresia to evaluate efficacy and safety for pediatric clinical decision-making.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, a comprehensive librarian-assisted search was conducted across PubMed, Cochrane Library, CINAHL, Scopus, and Web of Science up to December 2024. Studies comparing stented and non-stented endoscopic repairs in pediatric or neonatal populations were included. Two reviewers independently performed data extraction and quality assessment using ROB 2 for randomized trials and the Newcastle-Ottawa Scale for observational studies.</div></div><div><h3>Results</h3><div>Nine studies involving 336 patients for restenosis and 295 for granulation tissue analysis were included. Most patients were neonates or young infants (age range: 3–28 days). Stented procedures had significantly higher rates of restenosis (RR 2.21, 95 % CI 1.53–3.18, p &lt; 0.01) and granulation tissue formation (RR 1.95, 95 % CI 1.31–2.90, p &lt; 0.01). No significant differences were found in surgical success (RR 0.63, p = 0.05), bleeding (RR 0.26, p = 0.14), or polyp formation (RR 1.25, p = 0.79). Heterogeneity and publication bias were low.</div></div><div><h3>Conclusions</h3><div>Stenting after endoscopic repair of bilateral choanal atresia increases restenosis and granulation risks without clear benefit in surgical success or complication reduction. Routine stenting may not be warranted in neonates and infants.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"196 ","pages":"Article 112494"},"PeriodicalIF":1.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associational study of neonatal hearing screening results and common metabolic disorders","authors":"Benhong Ren ,&nbsp;Xiaoli Zhang ,&nbsp;Qingping Zhang ,&nbsp;Wenyuan Gan ,&nbsp;Ying Zhang ,&nbsp;Bin Guo ,&nbsp;Yi Wang","doi":"10.1016/j.ijporl.2025.112489","DOIUrl":"10.1016/j.ijporl.2025.112489","url":null,"abstract":"<div><h3>Background</h3><div>To analyze the association between neonatal hearing screening results and abnormal metabolic disease screening in Xining, Qinghai Province, and provide evidence-based insights for regional prevention and control strategies for neonatal hearing and metabolic diseases.</div></div><div><h3>Methods</h3><div>A total of 8631 neonates born in Xining, Qinghai Province, from January 1, 2017, to December 2024, were included. Data from hearing screening using otoacoustic emission (OAE) technology were retrospectively reviewed to evaluate the application efficacy of this technology in the early and accurate diagnosis of neonatal hearing impairment. The association between hearing screening results and the timing of intervention was simultaneously analyzed. During the same period, 3429 neonates born at Qinghai University Affiliated Hospital from January 1, 2022, to December 2024, were selected. Retrospective statistical analysis was performed on screening results for metabolic diseases such as congenital hypothyroidism and phenylketonuria (PKU). A Logistic regression model was used to explore the correlation between abnormal hearing screening and positive cases of metabolic diseases.</div></div><div><h3>Results</h3><div>1. Hearing Screening Results: Among 8,631 neonates, 1,134 cases (13.1%) failed the initial screening, and 44 cases (0.51%) failed the rescreening. Following follow-up and clinical confirmation, 4 neonates were definitively diagnosed with hearing impairment, while 7 cases were lost to follow-up. 2. Metabolic Disease Screening Results: A total of 3,429 neonates underwent metabolic disease screening, yielding 155 positive cases with an overall detection rate of 4.5%. The distribution of abnormal indicators was as follows: increased organic acids in 133 cases (accounting for 85.8% of positive cases), decreased adenosine triphosphate (ATP) in 55 cases (35.5%), reduced thyroid hormones and reduced melanin in 24 cases each (15.5% respectively), elevated blood ammonia in 13 cases (8.4%), complicated with jaundice in 5 cases (3.2%), and complicated with hypoglycemia in 3 cases (1.9%). 3. Correlation Analysis Results: Logistic regression model indicated a significant correlation between neonatal hearing loss and decreased ATP (<em>P</em>&lt;0.05).</div></div><div><h3>Conclusion</h3><div>1. This study suggests that decreased adenosine triphosphate (ATP) levels in newborns may be associated with hearing loss, preliminarily indicating that energy metabolic disorders might represent one of the potential pathological mechanisms involved in the development of hearing impairment. 2. The study data did not show a statistically significant association between reduced neonatal thyroid hormone levels and hearing loss. 3. Regarding the clinical application value and detection efficacy of neonatal acid metabolite testing, further exploration and validation are warranted through studies with larger sample sizes combined with long-term fol","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"196 ","pages":"Article 112489"},"PeriodicalIF":1.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-operative tympanic membrane perforation outcomes for cleft palate patients","authors":"Alexander Poulakis ,&nbsp;Michael S. Castle ,&nbsp;Matthew M. Carter ,&nbsp;Nathan D. Vandjelovic","doi":"10.1016/j.ijporl.2025.112495","DOIUrl":"10.1016/j.ijporl.2025.112495","url":null,"abstract":"<div><h3>Introduction</h3><div>Children with cleft palate (CP) have higher rates of eustachian tube dysfunction, leading to chronic otitis media, frequent tympanostomy tube (TT) placement, and ultimately tympanic membrane perforation (TMP), though the natural course of TMPs in this population has yet to be described.</div></div><div><h3>Methods</h3><div>An electronic medical record tool was used to identify patients with a diagnosis of CP and previous TT placement or TMP repair at a tertiary academic medical center. Patients with chronic TMP were identified by manual review. Qualities of the perforation, rate of resolution, and additional outcomes were analyzed. Chronic TMP was defined as a TM defect present on otoscopy at least 3 months apart, while TMP resolution was defined as an intact TM on any subsequent evaluation.</div></div><div><h3>Results</h3><div>One hundred-six total ears were analyzed. Sixty-four (60 %) ears developed a chronic TMP, of which 43 (67 %) were observed without intervention. Twenty-one (49 %) observed TMPs resolved spontaneously, nearly half of which occurred within 1 year. No instances of cholesteatoma developed among healed perforations. TMP resolution occurred significantly more frequently if preceded by TT duration less than 2 years (13/16 = 81 % v. 6/18 = 33 %, p = 0.0138), but no significant effect was noted when controlling for age and location on logistic regression analysis. Time to resolution was significantly shorter with smaller TMP size when controlling for age and duration of TT intubation (OR = 1.23x10⁻⁸; p = 0.041).</div></div><div><h3>Conclusion</h3><div>The presence of CP influences management decisions as the natural course of ear disease may be different. Perforations have the greatest chance to self-resolve within 1 year and may benefit most from operative closure thereafter. Knowledge of the rate of closure may be useful in TMP management strategies.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"196 ","pages":"Article 112495"},"PeriodicalIF":1.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of (val)ganciclovir on hearing in children with congenital cytomegalovirus infection","authors":"Elise De Cuyper ,&nbsp;Frederic Acke ,&nbsp;Annelies Keymeulen ,&nbsp;Els De Leenheer ,&nbsp;Helen Van Hoecke ,&nbsp;An Boudewyns ,&nbsp;Annick Gilles ,&nbsp;Marie Muylle ,&nbsp;Rudolf Kuhweide ,&nbsp;Liesbeth Royackers ,&nbsp;Christian Desloovere ,&nbsp;Margriet Verstreken ,&nbsp;Isabelle Schatteman ,&nbsp;Ingeborg Dhooge","doi":"10.1016/j.ijporl.2025.112491","DOIUrl":"10.1016/j.ijporl.2025.112491","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the effect of (val)ganciclovir on long-term hearing outcome.</div></div><div><h3>Methods</h3><div>This matched cohort study presents multicentric data of the Flemish CMV registry (Belgium) collected over 16 years. Treated and untreated cCMV-infected children with a minimal four-year audiological follow-up were included. Primary outcome was hearing evolution. Exact matching for risk factors of spontaneous hearing evolution was performed between the treated and untreated group. The average marginal treatment effect was calculated using a pooled regression model.</div></div><div><h3>Results</h3><div>Of the 525 children, 98 (18.7 %) were treated. Antiviral therapy did not significantly result in more hearing improvement (RR,1.56; 95 % CI,0.48 to 4.93) or less hearing deterioration (RR,0.89; 95 % CI,0.61 to 1.25). Treatment of children with unilateral congenital hearing loss with valganciclovir for six weeks prevented contralateral late-onset hearing loss compared to untreated children (RR,2.49∗10⁻⁸; 95 % CI,9.19∗10⁻⁹ to 7.71∗10⁻⁸). Similarly, late-onset hearing loss could be prevented in symptomatic children with bilateral normal hearing treated with ganciclovir for six weeks (RR,3.65∗10⁻⁷; 95 % CI,2.16∗10⁻⁷ to 6.21∗10⁻⁷). Prolongation from six weeks to six months showed no beneficial effect on hearing improvement (RR,4.61∗10⁻⁸; 95 % CI,1.07∗10⁻⁸ to 2.32∗10⁻⁷), hearing deterioration (RR,1.21; 95 % CI,0.43 to 2.25), or late-onset hearing loss (RR,1.95; 95 % CI,0.63 to 5.93).</div></div><div><h3>Conclusions</h3><div>(Val)ganciclovir for six weeks prevented late-onset hearing loss. No additional benefit of a six-month therapy was found. These novel findings can aid in treatment decision making. Future studies with a larger sample size and investigation on the effect of valganciclovir on long-term neurological outcome are needed.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"196 ","pages":"Article 112491"},"PeriodicalIF":1.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic analysis of the middle ear microbiome: A next-generation sequencing approach in pediatric patients with and without effusion","authors":"Safiye Göçer ,&nbsp;Oğuz Arı ,&nbsp;Celil Göçer ,&nbsp;Rıza Durmaz","doi":"10.1016/j.ijporl.2025.112487","DOIUrl":"10.1016/j.ijporl.2025.112487","url":null,"abstract":"<div><h3>Objectives</h3><div>Otitis media with effusion (OME) is one of the most common causes of reversible hearing loss in childhood. In recent years, host-microbiota interactions and alterations in microbiota composition associated with health and disease have gained increasing attention in the context of OME. This study aimed to investigate the bacterial microbiota composition of middle ear cavity (MEC) samples obtained from pediatric patients with and without OME. Microbiome differences were analyzed according to clinical groups and variables such as age and gender.</div></div><div><h3>Methods</h3><div>16S rRNA-based metagenomic sequencing was performed on MEC samples (n = 80) and nasopharyngeal samples (n = 20) obtained from 80 children—40 diagnosed with bilateral or unilateral OME (OME group) and 40 undergoing cochlear implant surgery without any history of otitis media (control group). The study cohort included 37 males and 43 females, aged between 2 and 11 years (mean age: 5.2 years).</div></div><div><h3>Results</h3><div>Sequencing analysis revealed that the phyla <em>Firmicutes</em> and <em>Proteobacteria</em> were dominant in MEC samples. In the OME group, <em>Firmicutes</em> were significantly more abundant, whereas <em>Proteobacteria</em> levels were reduced. At the genus level, <em>Alloiococcus</em> was significantly enriched in the OME group, while genera considered potentially protective, such as <em>Lactobacillus</em> and <em>Propionibacterium</em>, were significantly decreased. Age was not significantly associated with microbial richness or evenness, suggesting stability of microbiota composition across age groups. However, a significantly higher relative abundance of <em>Ralstonia</em> was observed in female patients, suggesting that gender-related hormonal or immunological differences may influence the middle ear microbiota.</div></div><div><h3>Conclusion</h3><div>This study identifies a distinct microbiota profile associated with OME and suggests that host factors, particularly gender, may contribute to shaping the microbial and immunological landscape of the middle ear. These findings also indicate that the microbial environment in OME may shift toward a low-diversity, pathobiont-dominant state.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"196 ","pages":"Article 112487"},"PeriodicalIF":1.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic role of Galectin-3 with routine blood parameters in PFAPA syndrome: prospective cohort study","authors":"Sanem Burc Dagli ,&nbsp;Murat Gumussoy ,&nbsp;Ali Kanik ,&nbsp;Murat Aksit ,&nbsp;İbrahim Cukurova","doi":"10.1016/j.ijporl.2025.112478","DOIUrl":"10.1016/j.ijporl.2025.112478","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"196 ","pages":"Article 112478"},"PeriodicalIF":1.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a role for whole genome sequencing in idiopathic vocal fold immobility?","authors":"Michelle M. Florentine ,&nbsp;Kastley Marvin ,&nbsp;Matthew T. Brigger","doi":"10.1016/j.ijporl.2025.112493","DOIUrl":"10.1016/j.ijporl.2025.112493","url":null,"abstract":"<div><div>Pediatric bilateral vocal fold immobility (BVFI) is most commonly congenital and idiopathic. Establishing an etiology is critical to providing appropriate management to prevent respiratory insufficiency and death. Genetic diseases may be an under-diagnosed cause of idiopathic BVFI. Here we report on two pediatric cases in which whole genome sequencing played a key role in the diagnosis of BVFI—in one case, BVFI resulted in a mortality and in the other case, the diagnosis of a genetic mutation altered the management and potentially the course of BVFI.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"196 ","pages":"Article 112493"},"PeriodicalIF":1.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}