Investigation of the protective and therapeutic effects of coenzyme Q10 on acoustic trauma-induced hearing loss in rats

IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY
Togay Müderris , Oben Yıldırım , Tankut Uzun , Serpil Mungan Durankaya , Nesibe Kahraman Çetin , Günay Kırkım , Osman Yılmaz
{"title":"Investigation of the protective and therapeutic effects of coenzyme Q10 on acoustic trauma-induced hearing loss in rats","authors":"Togay Müderris ,&nbsp;Oben Yıldırım ,&nbsp;Tankut Uzun ,&nbsp;Serpil Mungan Durankaya ,&nbsp;Nesibe Kahraman Çetin ,&nbsp;Günay Kırkım ,&nbsp;Osman Yılmaz","doi":"10.1016/j.ijporl.2025.112534","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Acoustic trauma is a process in which the sound energy coming into the ear is so high that it causes hearing loss. Although various treatments have entered clinical practice today, studies on the prevention and treatment of acoustic trauma continue. In our study, we investigated the protective and therapeutic effects of CoQ10 in rats with hearing loss due to acoustic trauma.</div></div><div><h3>Materials and method</h3><div>35 Wistar-type Albino rats were used in the study. The rats were randomly divided into five equal groups. The groups are the acoustic trauma group (group 1), the ethanol (solvent of CoQ10) group (group 2), the group given CoQ10 treatment after acoustic trauma (group 3), the control group (group 4), and the group given CoQ10 both before and after acoustic trauma (group 5). At the beginning of the experiment, after CoQ10 treatment and after acoustic trauma, the ABR test was performed in accordance with the experimental plan. At the end of the treatment, ABR was performed on all subjects and the subjects were sacrificed and their bilateral cochleas were excised. Cochleas were examined histopathologically.</div></div><div><h3>Results</h3><div>Hearing thresholds in the ABR performed on the last day of the study of rats that received CoQ10 after acoustic trauma and those that received CoQ10 both before and after acoustic trauma were significantly better than the measurements on the first day after acoustic trauma(p &lt; 0.05). In histopathological examination, it was observed that the rats in group 5 had more outer hair cells than those in groups 1 and 3. Marginal cell loss in the stria vascularis was less, and nuclear degeneration in the spiral ganglia was less.</div></div><div><h3>Conclusion</h3><div>In our study, it was determined that CoQ10 had both a protective and therapeutic effect on hearing loss due to acoustic trauma. Better ABR results were obtained in the group given CoQ10 both before and after acoustic trauma.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"197 ","pages":"Article 112534"},"PeriodicalIF":1.3000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of pediatric otorhinolaryngology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165587625003210","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Acoustic trauma is a process in which the sound energy coming into the ear is so high that it causes hearing loss. Although various treatments have entered clinical practice today, studies on the prevention and treatment of acoustic trauma continue. In our study, we investigated the protective and therapeutic effects of CoQ10 in rats with hearing loss due to acoustic trauma.

Materials and method

35 Wistar-type Albino rats were used in the study. The rats were randomly divided into five equal groups. The groups are the acoustic trauma group (group 1), the ethanol (solvent of CoQ10) group (group 2), the group given CoQ10 treatment after acoustic trauma (group 3), the control group (group 4), and the group given CoQ10 both before and after acoustic trauma (group 5). At the beginning of the experiment, after CoQ10 treatment and after acoustic trauma, the ABR test was performed in accordance with the experimental plan. At the end of the treatment, ABR was performed on all subjects and the subjects were sacrificed and their bilateral cochleas were excised. Cochleas were examined histopathologically.

Results

Hearing thresholds in the ABR performed on the last day of the study of rats that received CoQ10 after acoustic trauma and those that received CoQ10 both before and after acoustic trauma were significantly better than the measurements on the first day after acoustic trauma(p < 0.05). In histopathological examination, it was observed that the rats in group 5 had more outer hair cells than those in groups 1 and 3. Marginal cell loss in the stria vascularis was less, and nuclear degeneration in the spiral ganglia was less.

Conclusion

In our study, it was determined that CoQ10 had both a protective and therapeutic effect on hearing loss due to acoustic trauma. Better ABR results were obtained in the group given CoQ10 both before and after acoustic trauma.
辅酶Q10对大鼠听觉损伤性听力损失的保护和治疗作用研究
背景声创伤是一种进入耳朵的声音能量过高而导致听力丧失的过程。虽然各种治疗方法已进入临床实践,但对声损伤的预防和治疗的研究仍在继续。在我们的研究中,我们研究了辅酶q10对听损伤听力损失大鼠的保护和治疗作用。材料与方法采用wistar型白化大鼠35只。大鼠被随机分成五组。分为听伤组(1组)、乙醇(辅酶q10的溶剂)组(2组)、听伤后给予辅酶q10治疗组(3组)、对照组(4组)、听伤前后同时给予辅酶q10治疗组(5组)。实验开始时、CoQ10治疗后、声损伤后,按照实验计划进行ABR测试。治疗结束时,对所有受试者进行ABR,并处死受试者,切除双侧耳蜗。耳蜗行组织病理学检查。结果听伤后服用辅酶q10的大鼠和听伤前后同时服用辅酶q10的大鼠在研究最后一天的ABR剪切阈值均显著优于听伤后第一天的测量值(p < 0.05)。组织病理学检查发现,第5组大鼠的外毛细胞比第1、3组大鼠多。血管纹边缘细胞丢失较少,螺旋神经节核变性较少。结论在我们的研究中,我们确定辅酶q10对听觉创伤性听力损失具有保护和治疗作用。在声损伤前后给予辅酶q10的组获得了更好的ABR结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.20
自引率
6.70%
发文量
276
审稿时长
62 days
期刊介绍: The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信