International journal of pediatric otorhinolaryngology最新文献

Artificial intelligence in pediatric otolaryngology: A state-of-the-art review of opportunities and pitfalls 人工智能在儿科耳鼻喉科：机会和陷阱的最新审查

IF 1.2 4区医学

International journal of pediatric otorhinolaryngology Pub Date : 2025-05-04 DOI: 10.1016/j.ijporl.2025.112369

Nithya Navarathna , Adway Kanhere , Charlyn Gomez , Amal Isaiah

{"title":"Artificial intelligence in pediatric otolaryngology: A state-of-the-art review of opportunities and pitfalls","authors":"Nithya Navarathna , Adway Kanhere , Charlyn Gomez , Amal Isaiah","doi":"10.1016/j.ijporl.2025.112369","DOIUrl":"10.1016/j.ijporl.2025.112369","url":null,"abstract":"<div><h3>Background</h3><div>Artificial Intelligence (AI) and machine learning (ML) have transformative potential in enhancing diagnostics, treatment planning, and patient management. However, their application in pediatric otolaryngology remains limited as the unique physiological and developmental characteristics of children require tailored AI applications, highlighting a gap in knowledge.</div></div><div><h3>Purpose</h3><div>To provide a narrative review of current literature on the application of AI in pediatric otolaryngology, highlighting knowledge gaps, associated challenges and future directions.</div></div><div><h3>Results</h3><div>ML models have demonstrated efficacy in diagnosing conditions such as otitis media, adenoid hypertrophy, and pediatric obstructive sleep apnea through deep learning-based image analysis and predictive modeling. AI systems also show potential in surgical settings such as landmark identification during otologic surgery and prediction of middle ear effusion during tympanostomy tube placement. Telemedicine solutions and large language models have shown potential to improve accessibility to care and patient education. The principal challenges include flawed generalization of adult training data and the relative lack of pediatric data.</div></div><div><h3>Conclusions</h3><div>AI holds significant promise in pediatric otolaryngology. However, its widespread clinical integration requires addressing algorithmic bias, enhancing model interpretability, and ensuring robust validation across pediatric population. Future research should prioritize federated learning, developmental trajectory modeling, and psychosocial integration to create patient-centered solutions.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"194 ","pages":"Article 112369"},"PeriodicalIF":1.2,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the postoperative analgesic effects of bupivacaine and ropivacaine in infraorbital nerve block anesthesia for cheiloplasty in infants 布比卡因与罗哌卡因眶下神经阻滞麻醉对婴幼儿唇腭裂术后镇痛效果的比较

IF 1.2 4区医学

International journal of pediatric otorhinolaryngology Pub Date : 2025-05-03 DOI: 10.1016/j.ijporl.2025.112373

Wenjie Zhou , Yilin Li , Nan Lin , Zhiyu Cai , Chuanqing Mao , Yongzhen Lai , Meng Lu

{"title":"Comparison of the postoperative analgesic effects of bupivacaine and ropivacaine in infraorbital nerve block anesthesia for cheiloplasty in infants","authors":"Wenjie Zhou , Yilin Li , Nan Lin , Zhiyu Cai , Chuanqing Mao , Yongzhen Lai , Meng Lu","doi":"10.1016/j.ijporl.2025.112373","DOIUrl":"10.1016/j.ijporl.2025.112373","url":null,"abstract":"<div><h3>Obejective</h3><div>This prospective study aimed to evaluate the analgesic efficacy of ropivacaine and bupivacaine for infraorbital nerve block following cheiloplasty. Additionally, it investigated the safety and feasibility of these agents in infants and young children.</div></div><div><h3>Methods</h3><div>Participants were divided into three groups: Control (physiological saline), Group L (ropivacaine), and Group B (bupivacaine). Bilateral infraorbital nerve block anesthesia was performed at the beginning of surgery, followed by general anesthesia for the procedure. Postoperative pain was scored using the FLACC scale.</div></div><div><h3>Results</h3><div>Group B had a significantly lower heart rate post-surgery compared to the other groups (P < 0.05). FLACC pain scores at 30 min, 1 h, and 4 h post-surgery were significantly lower in Groups L and B compared to the control group (P < 0.05). Side effects included edema, hematoma, nausea, vomiting, cyanosis, and convulsions, with no adverse reactions in the control group. Group L had one case of lip cyanosis and convulsions, and Group B had one case of nausea and vomiting. No significant differences were found in age, weight, and surgical time among the three groups (P > 0.05).</div></div><div><h3>Conclusions</h3><div>Ropivacaine showed similar analgesic effects to bupivacaine but with higher safety for postoperative pain relief in cleft lip repair in infants and young children, suggesting its clinical utility.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112373"},"PeriodicalIF":1.2,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of cortical auditory maturation between children with cochlear implants VS normal hearing children attending mainstream school 植入人工耳蜗儿童与主流学校正常听力儿童皮质听觉成熟的比较

IF 1.2 4区医学

International journal of pediatric otorhinolaryngology Pub Date : 2025-04-29 DOI: 10.1016/j.ijporl.2025.112368

Nabihah Roslle , Wan Fazlina Wan Hashim , Khairul Farhah Khairuddin , Asma Abdullah , Rosnah Ismail , Noor Dina Hashim

{"title":"Comparison of cortical auditory maturation between children with cochlear implants VS normal hearing children attending mainstream school","authors":"Nabihah Roslle , Wan Fazlina Wan Hashim , Khairul Farhah Khairuddin , Asma Abdullah , Rosnah Ismail , Noor Dina Hashim","doi":"10.1016/j.ijporl.2025.112368","DOIUrl":"10.1016/j.ijporl.2025.112368","url":null,"abstract":"<div><h3>Background</h3><div>Cortical auditory evoked potential (CAEP) is an objective tool for assessing the development of central auditory pathways.</div></div><div><h3>Objectives</h3><div>Aimed to assess auditory growth and learning abilities of cochlear-implanted children in mainstream educational settings, comparing with normal-hearing peers. Additionally, the study investigated the association of auditory speech perception with academic performances.</div></div><div><h3>Materials and methods</h3><div>This was a quasi-experimental design post-test with control. Seventy-four children aged 7–12 years old were divided into two groups: CI recipient (n = 37) and normal-hearing (n = 37). P1 wave latency of CAEP was compared between groups. The auditory and speech performances of CI recipients were assessed using CAPS-II and SIRS. Screening Instrument for Targeting Education Risk (SIFTER) and a validated parental questionnaire used to evaluate educational performances. The association between auditory speech perception and academic performances was assessed.</div></div><div><h3>Results</h3><div>CI children exhibited prolonged P1 wave latency. Despite this difference, the educational performances were comparable to their peers, corresponding to high CAPS II and SIRS scores. Interestingly, no significant association between auditory speech perception and academic performance among CI children.</div></div><div><h3>Conclusion</h3><div>CAEP is reliable to quantify the development of cortical auditory pathways and should be routinely conducted in the management of CI. Cochlear implantation improves the auditory and academic performances of CI children.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112368"},"PeriodicalIF":1.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bonebridge BCI 602 implantation in syndromic and non-syndromic patients with bilateral microtia and aural atresia 骨桥BCI 602植入在双侧小耳闭锁综合征和非综合征患者中的应用

IF 1.2 4区医学

International journal of pediatric otorhinolaryngology Pub Date : 2025-04-29 DOI: 10.1016/j.ijporl.2025.112370

Tai-Yu Chen , Kuang-Hsu Lien , Kuan-Ting Yeh , Junior Chun-Yu Tu , Valerie Wai-Yee Ho , Kai-Chieh Chan

{"title":"Bonebridge BCI 602 implantation in syndromic and non-syndromic patients with bilateral microtia and aural atresia","authors":"Tai-Yu Chen , Kuang-Hsu Lien , Kuan-Ting Yeh , Junior Chun-Yu Tu , Valerie Wai-Yee Ho , Kai-Chieh Chan","doi":"10.1016/j.ijporl.2025.112370","DOIUrl":"10.1016/j.ijporl.2025.112370","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the safety and efficacy of Bonebridge bone conduction implant (BCI) 602 implantation in syndromic and non-syndromic patients with bilateral microtia and aural atresia (AA).</div></div><div><h3>Methods</h3><div>This retrospective study included 15 patients (3 syndromic, 12 non-syndromic) with bilateral microtia and AA who underwent BCI 602 implantation at a tertiary medical center between January 2022 and June 2024. Intraoperative and postoperative complications were recorded, with a minimum follow-up of six months. Audiological outcomes, including functional hearing gain (FHG), speech reception threshold (SRT), and word recognition score (WRS), were analyzed.</div></div><div><h3>Results</h3><div>No intraoperative complications occurred in any cases. One minor postoperative complication (6.7 %) was reported in a non-syndromic patient during follow-up. The mean unaided and aided sound field threshold pure tone averages were 60.3 ± 8.7 dB HL and 23.8 ± 3.9 dB HL, respectively, yielding an FHG of 36.6 ± 9.3 dB HL (<em>p</em> < 0.05). SRT improved from 57.0 ± 5.9 dB HL to 27.0 ± 6.5 dB HL in quiet and from 0.3 ± 8.5 dB SNR to −10.7 ± 4.2 dB SNR in noise. WRS increased from 45.1 ± 20.7 % to 89.9 ± 5.6 % in quiet and from 40.9 ± 20.9 % to 80.9 ± 13.8 % in noise (<em>p</em> < 0.05). Improvements in FHG, SRT, and WRS were comparable between syndromic and non-syndromic groups (<em>p</em> > 0.05).</div></div><div><h3>Conclusions</h3><div>The Bonebridge BCI 602 is a safe and effective option for hearing restoration in both syndromic and non-syndromic patients with bilateral microtia and AA. Its compact design enhances surgical safety and minimizes risks to critical structures, particularly in syndromic patients with complex temporal bone anatomy.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112370"},"PeriodicalIF":1.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in language outcomes after cochlear implantation in children: Exploring the impact of auditory verbal therapy duration (0, 1, or 3 years) 儿童人工耳蜗植入后语言预后的差异：探讨听觉语言治疗时间（0年、1年或3年）的影响

IF 1.2 4区医学

International journal of pediatric otorhinolaryngology Pub Date : 2025-04-29 DOI: 10.1016/j.ijporl.2025.112371

Kirsten Aaberg , Ida Jensen Friis , Camilla Bennick Slynge , Anders Britze , Louise Devantier

{"title":"Differences in language outcomes after cochlear implantation in children: Exploring the impact of auditory verbal therapy duration (0, 1, or 3 years)","authors":"Kirsten Aaberg , Ida Jensen Friis , Camilla Bennick Slynge , Anders Britze , Louise Devantier","doi":"10.1016/j.ijporl.2025.112371","DOIUrl":"10.1016/j.ijporl.2025.112371","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate the impact of Auditory Verbal Therapy (AVT) on spoken language and pragmatic skills five years after cochlear implantation in children enrolled in rehabilitation programs of varying durations (0, 1, 3 years).</div></div><div><h3>Methods</h3><div>The design was a retrospective cohort study, including 87 children with cochlear implants, grouped based on the duration of AVT: 19 in the 0-year group, 33 in the 1-year group, and 35 in the 3-year group. Language and pragmatic skills were assessed five years post-implantation, using the <em>Clinical Evaluation Language Fundamentals</em>.</div></div><div><h3>Results</h3><div>Significant differences were found in language development five years post-implant, with children receiving 3 years of AVT achieving higher Core Language Scores (CLS) and Expressive Language Index (ELI) scores than those with 0 or 1 year of AVT. No significant differences were found between the 0- and 1-year groups. The percentage of children performing within the normal range increased from 47 % (CLS) and 53 % (ELI) in the 0-year AVT group, to 61 % (CLS + ELI) in the 1-year AVT group, and 83 % and 80 %, respectively, in the 3-year AVT group. No group differences were found in pragmatic skills.</div></div><div><h3>Conclusion</h3><div>This study underscores the critical importance of early and extended AVT in facilitating optimal language development in children with cochlear implants. After five years, children who received 3 years of AVT continued to outperform those who received only 0 or 1 year of AVT. Longitudinal studies are needed to assess whether the effects of AVT on language and pragmatic skills persist or evolve over time.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"194 ","pages":"Article 112371"},"PeriodicalIF":1.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital nasal pyriform aperture stenosis: retrospective case series, systematic review, and pooled analysis 先天性鼻梨状孔狭窄：回顾性病例系列、系统评价和汇总分析

IF 1.2 4区医学

International journal of pediatric otorhinolaryngology Pub Date : 2025-04-26 DOI: 10.1016/j.ijporl.2025.112359

Amy E. Ensing, Aseeyah Islam, Dorina Kallogjeri, Judith E.C. Lieu

{"title":"Congenital nasal pyriform aperture stenosis: retrospective case series, systematic review, and pooled analysis","authors":"Amy E. Ensing, Aseeyah Islam, Dorina Kallogjeri, Judith E.C. Lieu","doi":"10.1016/j.ijporl.2025.112359","DOIUrl":"10.1016/j.ijporl.2025.112359","url":null,"abstract":"<div><h3>Background</h3><div>Congenital nasal pyriform aperture stenosis (CNPAS) is a rare and potentially life-threatening source of neonatal upper airway obstruction. Treatment can be medical or surgical. Our objective was to describe CNPAS presentation and management.</div></div><div><h3>Methods</h3><div>Pooled data analysis of records of children identified with CNPAS from relevant publications and between 2014 and 2024 at our institution was performed. Published studies identified by a medical librarian were assessed independently by two reviewers.</div></div><div><h3>Results</h3><div>From 210 abstracts, 170 were identified as relevant, and 106 studies were included. Data from 10 children with CNPAS from our institution and 310 from the medical literature were analyzed. The majority 74.2 % (n = 230) of our sample received a surgical intervention for CNPAS. Pyriform aperture diameter of children receiving only medical management (mean = 5.3 mm; SD = 1.6) was not different from that of children who received or were recommended surgery (mean = 5.1 mm; SD = 1.5) with a mean difference of 0.2 mm (95 % CI -0.4 to 0.7). Presence of apnea (adjusted odds ratio [aOR] = 9.1; 95 % CI 2.4 to 35) and stridor/noisy breathing (aOR = 3.9; 95 % CI 1.4 to 10.8) were associated with higher odds of having surgery performed or recommended.</div></div><div><h3>Conclusions</h3><div>Management decisions in CNPAS have been driven by individual patient presentation rather than pyriform aperture diameter. Clinicians should use pyriform aperture diameter as a diagnostic rather than prognostic tool, as a narrow pyriform aperture diameter may not necessitate surgery in the absence of severe symptoms.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112359"},"PeriodicalIF":1.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moral distress in Pediatric otolaryngology: A survey of ASPO members 儿童耳鼻喉科的道德困扰：对ASPO成员的调查

IF 1.2 4区医学

International journal of pediatric otorhinolaryngology Pub Date : 2025-04-26 DOI: 10.1016/j.ijporl.2025.112365

Andrew J. Redmann , Matthew M. Smith , Claire Washabaugh , Dan Benscoter , Catherine K. Hart

{"title":"Moral distress in Pediatric otolaryngology: A survey of ASPO members","authors":"Andrew J. Redmann , Matthew M. Smith , Claire Washabaugh , Dan Benscoter , Catherine K. Hart","doi":"10.1016/j.ijporl.2025.112365","DOIUrl":"10.1016/j.ijporl.2025.112365","url":null,"abstract":"<div><h3>Objectives</h3><div>1. Determine the prevalence of moral distress for pediatric otolaryngologists in North America.</div><div>2. Evaluate the impact of demographic variables on moral distress levels.</div></div><div><h3>Methods</h3><div>Moral distress is defined as “when one knows the right thing to do, but institutional constraints make it nearly impossible to pursue the right course of action”. The Moral Distress Survey-Revised (MDS-R) is a 21-question survey measuring moral distress in pediatric patients. A modified MDS-R (validated with pilot data in pediatric otolaryngology) was anonymously distributed to American Society of Pediatric Otolaryngology (ASPO) members. Descriptive statistics, bivariate and multivariate analysis were performed.</div></div><div><h3>Results</h3><div>Response rate was 86/656 (13 %). Mean modified MDS-R score was 49 (range 3–128), which is lower than that found in the literature for pediatric surgeons (mean 72), pediatric intensivists (means 57–86), and similar to pediatric oncologists (reported means 42–52). Female respondents had higher MDS-R scores than males (60 vs. 50). Providers in practice <20 years had higher moral distress scores than those practicing >20 years (54 vs. 43). Factors leading to higher degrees of distress involved communication breakdowns/lack of provider continuity and seeing other providers provide false hope to patients.</div></div><div><h3>Conclusion</h3><div>Pediatric Otolaryngologists have low degrees of moral distress compared to other pediatric subspecialists. Those with fewer years of experience have higher levels of moral distress. Further research is necessary to determine the impact of moral distress on the wellness of pediatric otolaryngologists.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112365"},"PeriodicalIF":1.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Esophageal pathology and the aerodigestive triple endoscopy for pediatric recurrent croup 小儿复发组食道病理及气消化三联内镜检查

IF 1.2 4区医学

International journal of pediatric otorhinolaryngology Pub Date : 2025-04-24 DOI: 10.1016/j.ijporl.2025.112367

Stephen Liangtjan Trisno , Michael Carver , Douglas Sidell , Seema Khan

{"title":"Esophageal pathology and the aerodigestive triple endoscopy for pediatric recurrent croup","authors":"Stephen Liangtjan Trisno , Michael Carver , Douglas Sidell , Seema Khan","doi":"10.1016/j.ijporl.2025.112367","DOIUrl":"10.1016/j.ijporl.2025.112367","url":null,"abstract":"<div><div>Recurrent croup (RC) is characterized by recurrent episodes of stridor, barking cough, and hoarseness. While viral infections are the primary cause in croup, RC is thought to be caused by non-infectious etiologies such as structural airway abnormalities, allergic disorders, airway hyperresponsiveness and gastroesophageal reflux (GERD). Recent studies have suggested a potential link between esophageal diseases, particularly GERD/reflux esophagitis and eosinophilic esophagitis (EoE), and RC. This retrospective study aims to explore the association between esophageal disorders and RC through a multidisciplinary approach. A total of 68 patients with RC were identified in our aerodigestive center, 47 of whom underwent dual or triple endoscopy. Of these, 17 patients (36 %) were found to have esophageal disease, including EoE (15 %) and reflux esophagitis (19 %). Notably, food allergies were significantly more prevalent in the EoE group, and all patients with EoE had reported GI symptoms previously. While airway abnormalities were common across all groups, there were no significant differences between patients with and without esophageal disease. The study highlights the prevalence of esophageal diseases in patients with RC, particularly EoE, and a multidisciplinary aerodigestive evaluation may be beneficial for diagnosing concomitant esophageal conditions. Further studies are needed to determine the causal relationship between esophageal disorders and RC.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112367"},"PeriodicalIF":1.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Tacrolimus on Development of Experimental Cholesteatoma 他克莫司对实验性胆脂瘤发展的影响

IF 1.2 4区医学

International journal of pediatric otorhinolaryngology Pub Date : 2025-04-24 DOI: 10.1016/j.ijporl.2025.112357

Gülay Aktar Uğurlu , Zeynep Kaptan , Burak Numan Uğurlu , Nuran Sungu , Hatice Karadaş , Şule Demirci , Sevim Aslan Felek , Necmi Arslan

{"title":"Effect of Tacrolimus on Development of Experimental Cholesteatoma","authors":"Gülay Aktar Uğurlu , Zeynep Kaptan , Burak Numan Uğurlu , Nuran Sungu , Hatice Karadaş , Şule Demirci , Sevim Aslan Felek , Necmi Arslan","doi":"10.1016/j.ijporl.2025.112357","DOIUrl":"10.1016/j.ijporl.2025.112357","url":null,"abstract":"<div><h3>Purpose</h3><div>Cholesteatoma is a benign yet aggressive middle ear tumor characterized by keratin accumulation and chronic inflammation, leading to bone resorption and severe complications. This study aimed to investigate the effects of Tacrolimus, a potent immunosuppressive agent, on cholesteatoma formation in a propylene glycol (PG)-induced experimental model.</div></div><div><h3>Methods</h3><div>Fifteen male Wistar Albino rats were used, with right ears serving as controls and left ears as the experimental group. Cholesteatoma was induced by injecting 60 % PG combined with Gentamicin and Saline into the middle ear. The experimental group received the same solution supplemented with Tacrolimus. Histological evaluation included keratinization, inflammation, fibrosis, and vascular proliferation. Statistical analysis was performed to compare the control and experimental groups.</div></div><div><h3>Results</h3><div>Experimental cholesteatoma formation was achieved in 80 % of ears injected with PG (12 out of 15 ears). In the Tacrolimus-treated group, cholesteatoma formation was observed in only 1 ear (6.7 %), while the remaining 14 ears showed no evidence of keratin lamellae (p < 0.05). Although Tacrolimus significantly inhibited epithelial keratinization and invagination, no significant differences were found between groups regarding acute or chronic inflammation, fibrosis, or vascular proliferation (p > 0.05).</div></div><div><h3>Conclusion</h3><div>Tacrolimus demonstrated a strong inhibitory effect on cholesteatoma formation in this experimental model by markedly reducing epithelial keratinization and invagination. These findings suggest Tacrolimus's potential as a novel therapeutic agent for cholesteatoma. However, further studies are required to assess its safety, long-term efficacy, and clinical applicability.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112357"},"PeriodicalIF":1.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of hearing aids on early prelingual auditory development in children with unilateral cochlear implantation: a linear mixed model for longitudinal data 助听器对单侧人工耳蜗植入儿童早期语前听觉发育的影响：纵向数据的线性混合模型

IF 1.2 4区医学

International journal of pediatric otorhinolaryngology Pub Date : 2025-04-24 DOI: 10.1016/j.ijporl.2025.112366

Mei Li , Wei-li Kong , Ning-ying Song

{"title":"Effects of hearing aids on early prelingual auditory development in children with unilateral cochlear implantation: a linear mixed model for longitudinal data","authors":"Mei Li , Wei-li Kong , Ning-ying Song","doi":"10.1016/j.ijporl.2025.112366","DOIUrl":"10.1016/j.ijporl.2025.112366","url":null,"abstract":"<div><h3>Introduction</h3><div>We conducted a liner mixed model to explore the two-year early prelingual auditory development (EPLAD) of children with and without hearing aids (HAs) after unilateral cochlear implantation (CI) through a longitudinal study.</div></div><div><h3>Methods</h3><div>86 children with unilateral CI were divided into CI + HA (46) and CI (40) groups. Their EPLAD was assessed using the Infant Toddler Meaningful Auditory Integration Scale (IT/MAIS) before CI and at 1st, 3rd, 6th, 12th, 18th, and 24th months post-activation. A spline function described the EPLAD trajectory, and a best-fitting curve predicted IT/MAIS score changes over time. A linear mixed model analyzed the effects of HAs on EPLAD.</div></div><div><h3>Results</h3><div>CI + HA group had significantly higher IT/MAIS scores pre-op and up to 18 months post-CI (p < 0.01). There was no significant difference in the trajectory of EPLAD among different sex and age groups (p > 0.05). ITMAIS, sound detection and sound recognition trajectory of CI + HA group was significantly different from that of CI group (p < 0.01). We constructed a predictive score of IT/MAIS, sound detection and sound recognition over time with high accuracy (R = 0.99).</div></div><div><h3>Conclusions</h3><div>Most of studies about the effects of HAs on auditory development after CI merely conducted cross-sectional approach, which cannot reflect the real changes of individuals. For children with unilateral cochlear implant, wearing hearing aids in the contralateral ear can continuously improve EPLAD. The auditory development of individual is a dynamic process, and longitudinal study is more advantage to explore the real differences.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112366"},"PeriodicalIF":1.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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