International journal of pediatric otorhinolaryngology最新文献

{"title":"Increased incidence of intracranial complications following pediatric sinogenic and otogenic infections in the post-COVID-19 Era: A systematic review and meta-analysis","authors":"Pranav A. Patel ,&nbsp;Asher T. Ripp ,&nbsp;Shaun A. Nguyen ,&nbsp;Alexander N. Duffy ,&nbsp;Zachary M. Soler ,&nbsp;Ramin Eskandari ,&nbsp;David R. White ,&nbsp;Rodney J. Schlosser","doi":"10.1016/j.ijporl.2025.112364","DOIUrl":"10.1016/j.ijporl.2025.112364","url":null,"abstract":"<div><h3>Background</h3><div>This systematic-review and meta-analysis aims to evaluate and summarize the prevalence of pediatric intracranial complications following sinogenic or otogenic infections before and after the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>A literature search was performed using the PubMed, Scopus, and CINAHL databases to answer the question: In pediatric patients, was there an increase in the prevalence or severity of intracranial complications due to sinogenic or otogenic infections during and after the COVID-19 pandemic? Publications which included primary data on patients under the age of 18 years old, focusing on intracranial complications following otogenic and sinogenic infections were included.</div></div><div><h3>Results</h3><div>Of 1025 abstracts screened, 18 studies were included. There were no significant differences in age or sex between the two cohorts. Compared to the pre-COVID era, post-COVID infections were more likely to have neurologic complications upon presentation [11.4 % (1.6–53.0) vs 50.1 % (13.9–86.2), p &lt; 0.01], cerebral venous sinus thrombosis (CVST) [14.1 % (10.6–18.2) vs 40.5 % (25.2–56.9), p &lt; 0.01], intraparenchymal abscess [40.3 % (43.9–72.2) vs 54.9 % (25.2–87.1), p &lt; 0.01], and meningitis [10.6 % (0.0–39.4) vs 40.2 % (13.4–70.8), p &lt; 0.01]. Metronidazole use [38.7 % (31.8–46.0) vs 71.9 % (51.3–88.6), p &lt; 0.01], craniectomy [16.1 % (1.3–42.8) vs 37.4 % (2.9–83.0), p = 0.02], and burr holes [16.8 % (11.5–23.3) vs 26.6 % (12.7–43.3), p = 0.02] were increased in the post-COVID cohort.</div></div><div><h3>Conclusion</h3><div>There are considerable differences in neurologic deficits, CVST, intraparenchymal abscesses, meningitis, and treatment modalities in pre- and post-COVID cohorts of children with intracranial complications of otorhinogenic origin. Further research is required to determine the underlying mechanism for these differences.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112364"},"PeriodicalIF":1.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of a phased onboarding program for novice advanced practice providers","authors":"Laurie Newton,&nbsp;Cecille Sulman","doi":"10.1016/j.ijporl.2025.112363","DOIUrl":"10.1016/j.ijporl.2025.112363","url":null,"abstract":"<div><h3>Background</h3><div>Nurse practitioners and physician assistants, collectively referred to as advanced practice providers (APPs), are trained generally even though they are often hired into specialty practices such as pediatric otolaryngology (ENT). Because of this, novice APPs require a thorough onboarding to allow them to have the knowledge and skills needed to care for today's complex otolaryngology patients. Standard onboarding programs for APPs are often lacking, and orientation varies across areas. The purpose of our project was to develop a standardized phased onboarding program to help with a successful transition to practice for novice APPs joining our academic pediatric ENT practice.</div></div><div><h3>Methods</h3><div>A phased onboarding tool was developed and piloted with a novice APP new hire in our specialty. The APP progresses through four phases during orientation, with scheduled formative and summative feedback sessions. Competency metrics are established with the goal of the novice APP meeting patient care goals at the advanced beginner level by the end of phase two and at the competent to proficient level by the end of phase four.</div></div><div><h3>Results</h3><div>This manuscript will share a newly developed phased onboarding and orientation program specific to pediatric ENT, including lessons learned, which has a goal for novice APPs to be completing their orientation in approximately 6 months.</div></div><div><h3>Conclusion</h3><div>Standardized onboarding is necessary to facilitate a successful transition to practice for novice APPs. This tool can be implemented in other pediatric otolaryngology practices and other specialties.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112363"},"PeriodicalIF":1.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of chewing gum on postoperative pain in children undergoing tonsillectomy","authors":"Sumbule Koksoy Vayısoglu ,&nbsp;Harun Gur ,&nbsp;Emine Oncu ,&nbsp;Onur Ismi","doi":"10.1016/j.ijporl.2025.112362","DOIUrl":"10.1016/j.ijporl.2025.112362","url":null,"abstract":"<div><h3>Aims</h3><div>The aim of this study was to investigate the impact of chewing gum on postoperative pain in pediatric patients undergoing tonsillectomy.</div></div><div><h3>Material and methods</h3><div>This study was conducted as a prospective, randomized controlled single-blind interventional study. Patients were randomized into two groups: control group which received a standard postoperative protocol and the chewing gum group which received the same postoperative protocol. Pain was evaluated by the Wong Baker scale.</div></div><div><h3>Results</h3><div>A total of 75 patients participated in the study, with 40 in the control group and 35 in the chewing gum group. The children's mean age and gender distribution were similar across the groups. According to the independent t-test results, there was a significant difference in pain levels between the chewing gum and control groups on all days. The pain levels in the chewing gum group were lower compared to the control group. Analgesic use was also lower in the gum group on all days (p &lt; 0.05). Generalized linear mixed model analysis confirmed a significant independent effect of chewing gum on pain scores (p &lt; 0.001), though the effect did not vary over time.</div></div><div><h3>Conclusion</h3><div>In conclusion, chewing gum may serve as a non-pharmacological method for postoperative pain management. In clinical practice, chewing gum could be a simple, low-cost, and easy-to-implement intervention.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112362"},"PeriodicalIF":1.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized clinical trial of non-opioid pain medications after intracapsular adenotonsillectomy","authors":"Nathan E. Lu,&nbsp;Amber D. Shaffer,&nbsp;Marina V. Rushchak,&nbsp;Raymond C. Maguire,&nbsp;Noel Jabbour,&nbsp;Allison B.J. Tobey,&nbsp;Jennifer L. McCoy ,&nbsp;David H. Chi","doi":"10.1016/j.ijporl.2025.112361","DOIUrl":"10.1016/j.ijporl.2025.112361","url":null,"abstract":"<div><h3>Background</h3><div>Our purpose was to determine if non-opioid pain control is safe and effective in the treatment of pain following intracapsular adenotonsillectomy (T&amp;A).</div></div><div><h3>Methods</h3><div>A randomized, open-label, controlled trial of children ages 3–17 undergoing intracapsular T&amp;A was conducted at a tertiary children's hospital April 2021–May 2023. Exclusions were concomitant procedures, Down syndrome, coagulopathy, craniofacial anomalies, and current opioid use. Participants were randomized to receive a prescription for oxycodone (opioid group) or not (non-opioid group). All patients received ibuprofen/acetaminophen. The primary outcome, average Wong-Baker FACES pain scores on post-operative days 0–14, was compared between groups using t-tests. The secondary outcome, emergency department (ED)/urgent care visits, was compared using logistic regression.</div></div><div><h3>Results</h3><div>Age (median 4, range 3–12) and gender (42/70, 60 % male) were similar in both groups. Pain diaries were returned by 21/36 (58 %) in the opioid group and 23/34 (68 %) of the non-opioid group. Average pain was not different between groups before (opioid: mean 3.2, 95 % CI 2.5–3.8; non-opioid: mean 3.3, 95 % CI 2.5–4.0) or after (opioid: mean: 1.1, 95 % CI 0.6–1.5; non-opioid mean: 1.0, 95 % CI 0.5–1.5) analgesics. Only 7/21 (33 %) of the opioid group took ≥1 dose of oxycodone; no patients in the non-opioid group requested an opioid prescription. There were no differences in peak pain scores, duration of analgesic use, ED/urgent care visits, or caregiver-reported symptoms or satisfaction between groups.</div></div><div><h3>Conclusions</h3><div>Pain scores were low compared with previous reports in children undergoing extracapsular T&amp;A, suggesting non-opioid management is appropriate for pain control in this population.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112361"},"PeriodicalIF":1.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary aerodigestive team meetings for the management of complex airway patients","authors":"Aryan Kalra ,&nbsp;Rachel Blokland ,&nbsp;Wendy Nicholls ,&nbsp;Raimundo Garcia-Matte ,&nbsp;Shyan Vijayasekaran","doi":"10.1016/j.ijporl.2025.112360","DOIUrl":"10.1016/j.ijporl.2025.112360","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the clinical profiles and management of patients discussed at our tertiary paediatric hospital's multidisciplinary aerodigestive team (ADT) meetings.</div></div><div><h3>Method</h3><div>Retrospective chart review of all patients discussed at the Perth Children's Hospital ADT meetings between December 2018 and July 2022. Patient demographics, clinical characteristics and meeting outcomes, including procedures, investigations and follow-up were reviewed.</div></div><div><h3>Results</h3><div>A total of 580 ADT meeting consults were recorded for 304 patients, with 116 patients requiring multiple consultations. The median age at time of consult was 2.74 years and 51.0 % of patients were male. The commonest aerodigestive tract disorders included tracheomalacia (20.7 %), laryngomalacia (20.7 %), laryngotracheal stenosis (13.2 %), gastro-oesophageal reflux (9.4 %) and tracheo-oesophageal fistula (9.4 %). A secondary diagnosis was seen in 45.5 % of patients, most commonly Trisomy 21 (10.2 %), Robin Sequence (4.9 %) and Cerebral Palsy (3.0 %). Children with secondary diagnoses (P &lt; 0.01), tracheostomy dependence (P &lt; 0.01), upper airway disorders (P &lt; 0.01) and oesophageal disorders (P &lt; 0.01) were more likely to require multiple ADT consults. Further investigations were ordered after 25.9 % of consults, most commonly polysomnography (14.9 %) and video fluoroscopic swallowing studies (6.1 %). A total of 742 procedures were performed to diagnose and/or treat aerodigestive disease. The commonest diagnostic procedures were microlaryngoscopy and bronchoscopy (46.9 %), upper gastrointestinal endoscopy (7.8 %) and sleep nasendoscopy (6.7 %). The commonest interventional surgical procedures were adenoidectomy (12.4 %), balloon dilation of laryngotracheal stenosis (9.4 %), steroid injection to laryngeal scar or granulation tissue (8.4 %) and supraglottoplasty (6.7 %).</div></div><div><h3>Conclusion</h3><div>The aerodigestive program utilises a multidisciplinary approach to manage a medically complex cohort of patients. This study presents a large sample of patients from an Otolaryngology-led aerodigestive program in Australia and is intended to guide development of aerodigestive programs across the world in various clinical contexts.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112360"},"PeriodicalIF":1.2,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the odor Stick identification test for Japanese (OSIT-J) in preschool Children: A study on odor identification and developmental correlations","authors":"Yuna Inada ,&nbsp;Masaharu Kato","doi":"10.1016/j.ijporl.2025.112353","DOIUrl":"10.1016/j.ijporl.2025.112353","url":null,"abstract":"<div><div>This study aimed to evaluate the applicability of the Odor Stick Identification Test for the Japanese (OSIT-J) among preschool children aged 4–6. The study sought to determine whether the OSIT-J, originally designed for adults, can effectively assess olfactory identification in young children, and explore its correlation with developmental factors. This observational study included 84 preschool children who took the OSIT-J and vocabulary tests. A developmental and daily contact experience questionnaire was administered to the parents. The OSIT-J included 12 odors that Japanese adults were familiar with, while children were asked to identify these odors using four alternatives. The vocabulary test assessed children's understanding of the terms used in the OSIT-J. Children's ability to identify odors was found to improve with age, particularly among girls. Significant correlations were observed between OSIT-J and developmental test scores (total, social, and language) and vocabulary test scores. However, no correlation was observed between daily contact experience and social communication questionnaire scores. The children easily identified certain odors, such as curry and Japanese orange. The OSIT-J could serve as a promising tool to assess the olfactory identification abilities of preschool children. The study highlights the role of vocabulary and social interactions in odor identification. This indicates the utility of also considering social and language development when difficulties with odor identification are observed in the preschool years. Future research should validate the effectiveness of this test in detecting olfactory disorders and explore its use in diverse populations.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112353"},"PeriodicalIF":1.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated oxidative stress in pediatric chronic rhinosinusitis","authors":"Nilay Çalışkan ,&nbsp;Fatih Dilek ,&nbsp;Eray Metin Güler ,&nbsp;Remzi Doğan ,&nbsp;Abdurrahim Koçyiğit ,&nbsp;Emin Özkaya","doi":"10.1016/j.ijporl.2025.112349","DOIUrl":"10.1016/j.ijporl.2025.112349","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112349"},"PeriodicalIF":1.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early life exposures and risk of salivary gland diseases in childhood: A 28-year nationwide cohort study","authors":"Christina Resende de Paiva ,&nbsp;Kathrine Kold Sørensen ,&nbsp;Stine Attrup Schrøder ,&nbsp;Jakob Foghsgaard ,&nbsp;Christian Torp-Pedersen ,&nbsp;Michael F. Howitz","doi":"10.1016/j.ijporl.2025.112354","DOIUrl":"10.1016/j.ijporl.2025.112354","url":null,"abstract":"<div><h3>Background</h3><div>Limited research has been conducted on salivary gland diseases in childhood, including disease etiology and associated risk factors. This study examines how early-life exposures influence the rate of salivary gland disease.</div></div><div><h3>Objective</h3><div>To access the association between early-life exposures and salivary gland disease in childhood as well as to examine sex and age distribution and time trends.</div></div><div><h3>Methods</h3><div>The study was a nested case control study in children, matching five controls to each case between 1994 and 2022. We assessed the association between seven early-life exposures and three categories of salivary gland diseases: juvenile recurrent parotitis (JRP), salivary stones and salivary retention cysts. Conditional logistic regression was used to estimate hazard ratios (HRs) for each association.</div></div><div><h3>Results</h3><div>We identified 4778 cases and 23,890 controls: 2637 cases of JRP, 765 cases of salivary stones and 1376 cases of salivary retention cysts. Preterm birth (HR 1.24, 95 % CI 1.05; 1.47), low birth weight for gestational age (HR 1.38, 95 % CI 1.13; 1.69), young maternal age (HR 1.53, 95 % CI 1.20; 1.94) and low income (HR 1.27, 95 % CI 1.11; 1.45) were all positively associated with JRP. Maternal overweight (HR 0.85, 95 % CI 0.74; 0.97) had a negative association with JRP. No early-life exposure was significantly associated with salivary stones or retention cysts.</div></div><div><h3>Conclusion</h3><div>Children born preterm, small for gestational age, by young mothers, and with low household income, had an increased rate of developing nonspecific salivary gland disease, likely juvenile recurrent parotitis. In contrast, such associations were not identified for any other salivary gland disease.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112354"},"PeriodicalIF":1.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IQGAP3 deficiency leads to non-syndromic hearing loss via inhibition of CDC42 enzyme activity","authors":"Yu Li ,&nbsp;Haipeng Dong ,&nbsp;Xiaoya Wang ,&nbsp;Fuping Qian ,&nbsp;Junzhe Huang ,&nbsp;Chao Hou ,&nbsp;Hao Qin ,&nbsp;Yuehong Liu ,&nbsp;Shuang Feng ,&nbsp;Wenlong Liu ,&nbsp;Shengli Gao ,&nbsp;Changzhi Sun ,&nbsp;Yanqiu Chen ,&nbsp;Renzhong Luo ,&nbsp;Chunfu Dai ,&nbsp;Ru Zhang ,&nbsp;Hongyan Liu ,&nbsp;Luping Zhang ,&nbsp;Yan Zheng ,&nbsp;Na Li ,&nbsp;Hao Hu","doi":"10.1016/j.ijporl.2025.112358","DOIUrl":"10.1016/j.ijporl.2025.112358","url":null,"abstract":"<div><h3>Background</h3><div>Genetic factors are important causes of congenital hearing loss. To better understand hereditary hearing loss, we performed in-depth clinical and molecular analysis of families with congenital hearing loss and a new disease-related gene, <em>IQGAP3</em>, was identified in this process. This gene encodes a protein that belongs to the IQGAP family which is well known as a GTPase-activating protein involved in various cellular functions. However, there is no research on the relationship between <em>IQGAP3</em> and the auditory system.</div></div><div><h3>Method</h3><div>This study was conducted at Guangzhou Women and Children's Medical Center and Nantong University from 2019 to 2023 to confirm the relationship between defective IQGAP3 and hearing loss, and further explore the underlying molecular mechanism. We constructed the <em>iqgap3</em> knockdown zebrafish model, primary mouse inner progenitor cell model and <em>IQGAP3</em>-knockout HEK293T cell line for this research.</div></div><div><h3>Result</h3><div>We found that <em>IQGAP3</em> deficiency led to abnormal development of the auditory system and impaired auditory function in zebrafish. In vitro studies showed that loss of this gene's function resulted in a 40.29 % reduction in EdU-positive cells and a 44.25 % decrease in Ki67-positive cells in mouse inner ear progenitor cells, indicating reduced proliferation. This can be linked with inhibition of CDC42 enzymatic activity and the blockade of the Wnt-catenin pathway.</div></div><div><h3>Conclusion</h3><div>We identified <em>IQGAP3</em> as a novel potential causative gene in hereditary hearing loss. Our findings provide important insights into the molecular basis of hereditary hearing loss.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112358"},"PeriodicalIF":1.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of an optical coherence tomography middle ear scope: Interim results of the modification of antibiotic treatment intervention in children (OTO-MATIC) pragmatic cluster randomized controlled trial (RCT)","authors":"April Zambelli-Weiner ,&nbsp;Brian H. Nathanson ,&nbsp;Frank Calcagno ,&nbsp;John Ansley ,&nbsp;Karina Vattana ,&nbsp;Bonnie Burnette-Vick","doi":"10.1016/j.ijporl.2025.112356","DOIUrl":"10.1016/j.ijporl.2025.112356","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the impact of a novel Optical Coherence Tomography (OCT) otoscope on the number of antibiotic prescriptions written for pediatric patients presenting to a primary care office with ear-related complaints, compared to the Standard of Care (SOC), a traditional otoscope.</div></div><div><h3>Study Design</h3><div>Planned interim analysis of the One Year OTO-MATIC Randomized Controlled Trial (RCT), multicenter, real-world effectiveness study. Pediatric patients presenting with ear-related complaints were seen by a provider previously randomized into the SOC or Intervention arm. The primary outcome was reduced antibiotic prescriptions (clinician rate and number of rounds per patient) for Intervention participants compared to the SOC participants. Secondary outcomes included changes in treatment recommendations at Baseline Visit (BV), including singular versus multimodal treatments, and referrals to an otolaryngologist, specifically.</div></div><div><h3>Results</h3><div>At the time of the interim database lock, there were 248 participants enrolled across four sites and 16 providers who had completed the BV. Our results demonstrate that the OCT intervention reduced the odds of antibiotic prescribing by 50 % compared to the SOC (OR = 0.50, 95 % CI: 0.45–0.56). Additionally, providers in the Intervention group were significantly more likely to initiate a single therapeutic modality versus multiple, often disparate modalities (91.6 % vs. 73.8 %, p &lt; 0.001, respectively).</div></div><div><h3>Conclusions</h3><div>Interim results suggest the OCT imaging technology (OtoSight, PhotoniCare) improves antibiotic stewardship with clinicians in the OCT arm having a reduced likelihood of prescribing antibiotics compared to the SOC arm. Overall, changes in provider prescribing patterns and therapeutic management of the patient are consistent with increased diagnostic certainty<strong>.</strong></div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112356"},"PeriodicalIF":1.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}