International journal of pediatric otorhinolaryngology最新文献

{"title":"IQGAP3 deficiency leads to non-syndromic hearing loss via inhibition of CDC42 enzyme activity","authors":"Yu Li ,&nbsp;Haipeng Dong ,&nbsp;Xiaoya Wang ,&nbsp;Fuping Qian ,&nbsp;Junzhe Huang ,&nbsp;Chao Hou ,&nbsp;Hao Qin ,&nbsp;Yuehong Liu ,&nbsp;Shuang Feng ,&nbsp;Wenlong Liu ,&nbsp;Shengli Gao ,&nbsp;Changzhi Sun ,&nbsp;Yanqiu Chen ,&nbsp;Renzhong Luo ,&nbsp;Chunfu Dai ,&nbsp;Ru Zhang ,&nbsp;Hongyan Liu ,&nbsp;Luping Zhang ,&nbsp;Yan Zheng ,&nbsp;Na Li ,&nbsp;Hao Hu","doi":"10.1016/j.ijporl.2025.112358","DOIUrl":"10.1016/j.ijporl.2025.112358","url":null,"abstract":"<div><h3>Background</h3><div>Genetic factors are important causes of congenital hearing loss. To better understand hereditary hearing loss, we performed in-depth clinical and molecular analysis of families with congenital hearing loss and a new disease-related gene, <em>IQGAP3</em>, was identified in this process. This gene encodes a protein that belongs to the IQGAP family which is well known as a GTPase-activating protein involved in various cellular functions. However, there is no research on the relationship between <em>IQGAP3</em> and the auditory system.</div></div><div><h3>Method</h3><div>This study was conducted at Guangzhou Women and Children's Medical Center and Nantong University from 2019 to 2023 to confirm the relationship between defective IQGAP3 and hearing loss, and further explore the underlying molecular mechanism. We constructed the <em>iqgap3</em> knockdown zebrafish model, primary mouse inner progenitor cell model and <em>IQGAP3</em>-knockout HEK293T cell line for this research.</div></div><div><h3>Result</h3><div>We found that <em>IQGAP3</em> deficiency led to abnormal development of the auditory system and impaired auditory function in zebrafish. In vitro studies showed that loss of this gene's function resulted in a 40.29 % reduction in EdU-positive cells and a 44.25 % decrease in Ki67-positive cells in mouse inner ear progenitor cells, indicating reduced proliferation. This can be linked with inhibition of CDC42 enzymatic activity and the blockade of the Wnt-catenin pathway.</div></div><div><h3>Conclusion</h3><div>We identified <em>IQGAP3</em> as a novel potential causative gene in hereditary hearing loss. Our findings provide important insights into the molecular basis of hereditary hearing loss.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112358"},"PeriodicalIF":1.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoiding frenotomies and improving health equity: Findings from a paradigm shift newborn feeding difficulties model","authors":"Inderpreet Kaur Khalsa ,&nbsp;Alyson Pappas ,&nbsp;Margaret Cafferkey ,&nbsp;Grace Banik ,&nbsp;Kristina W. Rosbe","doi":"10.1016/j.ijporl.2025.112355","DOIUrl":"10.1016/j.ijporl.2025.112355","url":null,"abstract":"<div><h3>Importance</h3><div>Newborn feeding difficulties are increasingly attributed to ankyloglossia, leading to a surge in frenotomy procedures despite limited high-level evidence supporting its effectiveness. Disparities in access to appropriate feeding assessments contribute to potential surgical overtreatment and inequities in care.</div></div><div><h3>Objective</h3><div>To evaluate the impact of a paradigm shift newborn feeding difficulties model on clinical care patterns and health equity.</div></div><div><h3>Design, Setting, and Participants</h3><div>A retrospective cohort study of infants (&lt;6 months) with ankyloglossia-related ICD-9/ICD-10 codes at a tertiary academic pediatric hospital's otolaryngology outpatient clinic between 2017 and 2024, comparing pre-model (2017–2023) and post-model (2023–2024) cohorts.</div></div><div><h3>Main outcomes and measures</h3><div>Primary outcomes included certified speech-language pathologist (SLP) and lactation consultant (CLC) evaluations, ear, nose, and throat (ENT) visits, and frenotomy rates. Sociodemographic disparities in access and treatment were analyzed using multivariable logistic regression and mediation analysis.</div></div><div><h3>Results</h3><div>Of 1454 patients, 1171 were pre-model and 283 were post-model. Post-model patients were older (5.3 vs. 3.6 weeks, P &lt; 0.001), more likely to have public insurance (34.3% vs. 27.4%, P = 0.02), and had increased SLP/CLC visits (50.9% vs. 0.9%, P &lt; 0.001), reduced ENT visits (61.8% vs. 99.7%, P &lt; 0.001), and decreased frenotomy rates (17.7% vs. 45.4%, P &lt; 0.001). Pre-model patients were also less likely to receive frenotomy if had non-English language (AOR: 0.34; p = 0.001) and public insurance (AOR: 0.56; p = 0.002); for post-model patients, these disparities were not present. Mediation analysis indicated that the model mitigated the negative effect of public insurance on SLP/CLC access by 54%.</div></div><div><h3>Conclusions and relevance</h3><div>Implementing a paradigm shift newborn feeding difficulties model resulted in a significant shift in clinical care patterns, with increased utilization of SLP/CLC services and reduced frenotomies. The model also improved access to care for publicly insured patients, demonstrating its potential to enhance health equity and optimize feeding difficulty management.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"194 ","pages":"Article 112355"},"PeriodicalIF":1.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of an optical coherence tomography middle ear scope: Interim results of the modification of antibiotic treatment intervention in children (OTO-MATIC) pragmatic cluster randomized controlled trial (RCT)","authors":"April Zambelli-Weiner ,&nbsp;Brian H. Nathanson ,&nbsp;Frank Calcagno ,&nbsp;John Ansley ,&nbsp;Karina Vattana ,&nbsp;Bonnie Burnette-Vick","doi":"10.1016/j.ijporl.2025.112356","DOIUrl":"10.1016/j.ijporl.2025.112356","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the impact of a novel Optical Coherence Tomography (OCT) otoscope on the number of antibiotic prescriptions written for pediatric patients presenting to a primary care office with ear-related complaints, compared to the Standard of Care (SOC), a traditional otoscope.</div></div><div><h3>Study Design</h3><div>Planned interim analysis of the One Year OTO-MATIC Randomized Controlled Trial (RCT), multicenter, real-world effectiveness study. Pediatric patients presenting with ear-related complaints were seen by a provider previously randomized into the SOC or Intervention arm. The primary outcome was reduced antibiotic prescriptions (clinician rate and number of rounds per patient) for Intervention participants compared to the SOC participants. Secondary outcomes included changes in treatment recommendations at Baseline Visit (BV), including singular versus multimodal treatments, and referrals to an otolaryngologist, specifically.</div></div><div><h3>Results</h3><div>At the time of the interim database lock, there were 248 participants enrolled across four sites and 16 providers who had completed the BV. Our results demonstrate that the OCT intervention reduced the odds of antibiotic prescribing by 50 % compared to the SOC (OR = 0.50, 95 % CI: 0.45–0.56). Additionally, providers in the Intervention group were significantly more likely to initiate a single therapeutic modality versus multiple, often disparate modalities (91.6 % vs. 73.8 %, p &lt; 0.001, respectively).</div></div><div><h3>Conclusions</h3><div>Interim results suggest the OCT imaging technology (OtoSight, PhotoniCare) improves antibiotic stewardship with clinicians in the OCT arm having a reduced likelihood of prescribing antibiotics compared to the SOC arm. Overall, changes in provider prescribing patterns and therapeutic management of the patient are consistent with increased diagnostic certainty<strong>.</strong></div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112356"},"PeriodicalIF":1.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing ankyloglossia information on TikTok: A cross- sectional study","authors":"Kathryn Mozzochi ,&nbsp;Gabrielle Martin ,&nbsp;Stephen R. Chorney ,&nbsp;Lindsay Sobin","doi":"10.1016/j.ijporl.2025.112351","DOIUrl":"10.1016/j.ijporl.2025.112351","url":null,"abstract":"<div><h3>Introduction</h3><div>The American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) developed a clinical consensus on ankyloglossia in children to improve understanding of controversies and increase family-centered care. The breadth of information on ankyloglossia available on social media and the consistency with AAO-HNSF consensus remains underexplored.</div></div><div><h3>Methods</h3><div>A cross-sectional analysis was performed on the top 100 publicly available TikTok videos using the search term “tongue tie.” Video metrics and stakeholders were determined and were classified as informational, anecdotal, promotional, advice-seeking, or entertainment. Informational content was compared to the AAO-HNSF consensus statements on ankyloglossia.</div></div><div><h3>Results</h3><div>The mean number of views for the top videos on ankyloglossia was 1.4 million (SD: 2.6 million) with a mean of 88,009 “likes” (SD: 250,136) and 781 comments (SD: 1805). Only 2% of videos were created by otolaryngologists but dentists, lactation consultants, and other physicians were frequently represented. Videos were classified as informational (41%) or anecdotal (41%) and the most frequent stakeholder was an adult impacted by ankyloglossia (37%). The top theme explored was frenotomy experience for both written (20%) and audio (15%) information. Among informational videos, only 12.5% were completely consistent with AAO-HNSF consensus while most videos (41%) presented information that was partially consistent with consensus statements.</div></div><div><h3>Conclusions</h3><div>Ankyloglossia is frequently discussed on social media and families often engage with information shared by non-otolaryngologists. Providers should recognize where themes may be inconsistent with the published consensus on ankyloglossia and develop strategic approaches to achieve the AAO-HNSF goal of family-centered care.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112351"},"PeriodicalIF":1.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early cochlear implantation in children with complex medical needs: A multidisciplinary approach","authors":"Dani Stern ,&nbsp;Laura Greaver ,&nbsp;Steven Hamilton ,&nbsp;Samantha Bothwell","doi":"10.1016/j.ijporl.2025.112352","DOIUrl":"10.1016/j.ijporl.2025.112352","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine if children with hearing loss and additional medical diagnoses are achieving early cochlear implantation when compared to their peers with hearing loss as their sole diagnosis.</div></div><div><h3>Study design</h3><div>Retrospective study.</div></div><div><h3>Setting</h3><div>Pediatric outpatient clinic.</div></div><div><h3>Patients</h3><div>43 infants diagnosed with bilateral hearing loss, at least severe to profound sensorineural hearing loss (SNHL) in one ear, by three months of age and received cochlear implant(s) between 2017 and 2022.</div></div><div><h3>Main outcome measure</h3><div>Difference in cochlear implant (CI) evaluation time between patients with additional medical diagnoses and patients with hearing loss only.</div></div><div><h3>Results</h3><div>20 patients had additional diagnoses and 23 had hearing loss without other diagnoses. On average, patients with additional diagnoses had a longer CI evaluation time than patients without an additional diagnosis (13.5 months evaluation period for patients with additional diagnosis vs 12 months for patients without additional diagnosis). Appointments prior to cochlear implantation were reviewed for both groups. There was no difference in the number of appointments with the core CI team between the two groups studied. Patients with additional diagnoses had significantly more appointments with specialties outside of the core CI team prior to cochlear implantation than their peers.</div></div><div><h3>Conclusions</h3><div>Patients with additional diagnoses had a longer CI evaluation time than those with hearing loss alone. This may be attributed to the need for appointments with medical specialties outside of the core CI team. A medical diagnosis in addition to hearing loss should not preclude a child from progressing through the candidacy evaluation process. However, it may be helpful to manage expectations regarding the potential delays in cochlear implantation.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112352"},"PeriodicalIF":1.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative caregiver decision regret following velopharyngeal dysfunction surgery","authors":"Rohit Nallani ,&nbsp;Nathan Farrokhian ,&nbsp;Meghan Tracy ,&nbsp;Kevin J. Sykes ,&nbsp;Jill Arganbright","doi":"10.1016/j.ijporl.2025.112348","DOIUrl":"10.1016/j.ijporl.2025.112348","url":null,"abstract":"<div><h3>Background</h3><div>Decision regret (DR) is a powerful factor in medical decision-making, particularly for surgical decisions which carry multiple risks, impact quality of life (QOL), and have uncertain outcomes. While prior studies have investigated caregiver DR after tonsillectomy and otologic surgery, there is a paucity of data assessing DR following pediatric otolaryngology procedures. The aim of this study is to measure DR following velopharyngeal dysfunction (VPD) surgery.</div></div><div><h3>Methods</h3><div>A cross-sectional survey study with chart review was performed of caregivers of children who had VPD surgery performed by a single surgeon at a tertiary children's hospital. Demographic, medical, and surgical history were collected. Surveys assessed postoperative DR (scale 0–100), satisfaction with surgery (0-10), caregiver engagement in decision making, and QOL using the VPI Effects on Life Outcomes (VELO)-parent instrument (0–100).</div></div><div><h3>Results</h3><div>Of 59 caregivers who received the survey, 27 (45.8 %) completed the surveys. Caregivers felt involved in the decision for surgery (85 %). Postoperative caregiver-reported QOL (mean 81.5) and satisfaction (mean 9.4) were overall high. DR was low (mean 4.4), with 22 caregivers (78.6 %) reporting zero DR. Compared to those with no regret, those with DR &gt; 0 reported lower satisfaction (mean 9.7 vs 8.0, p = 0.002) and worse speech limitations (mean 81.2 vs 67.1, p = 0.015) or situational difficulty (mean 77.7 vs. 51.0, p &lt; 0.001) on VELO subscales.</div></div><div><h3>Conclusion</h3><div>While DR was overall low following VPD surgery, presence of DR was associated with worse speech-related QOL. Further prospective and multi-institutional study of DR is needed in pediatric otolaryngology to identify predictors of regret and understand treatment outcomes.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112348"},"PeriodicalIF":1.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic rhinitis in children is associated with high serum levels of zonulin","authors":"Burcu Tahire Koksal ,&nbsp;Metin Aldemir ,&nbsp;Caner İncekaş","doi":"10.1016/j.ijporl.2025.112350","DOIUrl":"10.1016/j.ijporl.2025.112350","url":null,"abstract":"<div><h3>Background</h3><div>Allergic rhinitis (AR) is a common chronic disease characterised by nasal membrane inflammation. Inflammation and epithelial barrier dysfunction play significant roles in the pathogenesis of allergic diseases.</div></div><div><h3>Methods</h3><div>The study included 88 children with AR and 50 healthy controls. We measured serum zonulin and haptoglobin levels and compared the groups.</div></div><div><h3>Results</h3><div>Children with AR had a higher median value of zonulin than healthy children [(11 (4.21–35.95) vs. 8.81 (3.59–47.72) ng/mL, respectively] (p = 0.024). Median value of haptoglobin/zonulin ratio was lower in children with AR [7.91 (0.46–31.93)] compared to healthy controls [11.07 (0.77–74.37), p = 0.011)]. Serum zonulin, haptoglobin levels and the haptoglobin/zonulin ratio did not differ significantly between children with persistent and intermittent AR.</div></div><div><h3>Conclusion</h3><div>High serum zonulin levels and low haptoglobin/zonulin ratios in children show an increased association with AR. Our results may support that inflammation is increased, intestinal permeability and preventive mechanisms to decrease oxidative damage are disrupted in children with AR.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112350"},"PeriodicalIF":1.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of imperforate submandibular duct: A systematic literature review and case report","authors":"Abdurrahman Abdurrob ,&nbsp;Bamdad Tayyari ,&nbsp;Madeline Goosmann ,&nbsp;Ilaaf Darrat","doi":"10.1016/j.ijporl.2025.112333","DOIUrl":"10.1016/j.ijporl.2025.112333","url":null,"abstract":"<div><h3>Background</h3><div>Imperforate submandibular ducts are rare with a broad differential including lymphatic malformation, congenital ranula, and thyroglossal duct cyst. Prompt evaluation is important as treatment differs based on the diagnosis. This systematic review aimed to characterize treatments and outcomes for management of imperforate submandibular ducts while describing 2 new cases.</div></div><div><h3>Methods</h3><div>The following systematic review was performed using PubMed and EMBASE: imperforate submandibular duct or congenital atresia submandibular duct. All associated papers were also included. Demographics, birth history, symptoms, treatment, and outcomes were collected.</div></div><div><h3>Results</h3><div>Sixteen articles were included with 22 patients presenting with imperforate submandibular ducts. Most patients were male (67 %), half of them were born at term (50 %), and 15 (62 %) had unilateral imperforate ducts. Eight patients had bilateral presentation. The mean age for initial treatment was 3.5 months. Treatment varied from 11 (48 %) patients undergoing simple incision only, 3 (13 %) underwent incision and ductoplasty, 4 (17 %) underwent marsupialization and ductoplasty, 3 (13 %) underwent marsupialization only, and 2 (9 %) underwent incision and marsupialization. Mean follow-up without recurrence was 20 months. One complication was reported, restenosis after incision only. Two patients presented to our health system a month apart, one male and one female, and both with unilateral cysts. One patient underwent incision and ductoplasty with no recurrence at the 1-week postoperative visit. The second patient is pending incision and ductoplasty.</div></div><div><h3>Conclusions</h3><div>Although an exceedingly rare condition, imperforate submandibular duct cysts more often present in males, unilaterally, and can be managed via multiple methods; however, marsupialization has shown no reported recurrences.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112333"},"PeriodicalIF":1.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic disparities in receipt of cochlear implantation surgery in American children in 2016","authors":"Julia H. Garland ,&nbsp;Dean G. Kennedy ,&nbsp;Taylor L. Jamil ,&nbsp;Aneesh A. Patel ,&nbsp;Jessica R. Levi ,&nbsp;Bita Naimi","doi":"10.1016/j.ijporl.2025.112319","DOIUrl":"10.1016/j.ijporl.2025.112319","url":null,"abstract":"<div><h3>Objective</h3><div>This study strives to determine how social determinants of health impact the rate at which pediatric patients receive cochlear implantations.</div></div><div><h3>Methods</h3><div>The 2016 Kids Inpatient Database was used to determine how different socioeconomic factors statistically impacted the rates of patients receiving cochlear implants. A two-sample independent <em>t</em>-test, univariate, and multivariate regression were used.</div></div><div><h3>Results</h3><div>Patients with CI surgery were younger and had longer inpatient stays (p &lt; 0.001 &amp; p = 0.017, respectively). Asian/Island Pacific patients were proportionately more likely to receive CI surgery (p = 0.003). Patients visiting hospitals in the South and Midwest regions of America were less likely to receive CI surgery (p &lt; 0.001 &amp; p = 0.004, respectively). Patients in the West and Northeast were more likely to receive implantation (p = 0.019).</div></div><div><h3>Conclusion</h3><div>Black and Hispanic children were the least likely to receive implantation, while white and Asian children were more likely to receive them. Patients in the South and Midwest were noted to be less likely to receive implantation. To enhance the quality and efficiency of care, it is necessary to identify and address these disparities to achieve more equitable healthcare for pediatric sensorineural hearing loss patients.</div></div>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"194 ","pages":"Article 112319"},"PeriodicalIF":1.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-risk populations for developing mastoiditis: Consequences on antibiotic treatment for acute otitis media","authors":"Ayalon Hadar ,&nbsp;Jameel Ghantous ,&nbsp;Adiel Cohen ,&nbsp;Jean-Yves Sichel ,&nbsp;Chanan Shaul ,&nbsp;Pierre Attal","doi":"10.1016/j.ijporl.2025.112347","DOIUrl":"10.1016/j.ijporl.2025.112347","url":null,"abstract":"","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"193 ","pages":"Article 112347"},"PeriodicalIF":1.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}