儿童过敏性鼻炎与高血清佐纳林水平有关

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology Pub Date : 2025-04-11 DOI:10.1016/j.ijporl.2025.112350

Burcu Tahire Koksal , Metin Aldemir , Caner İncekaş

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引用次数: 0

摘要

变应性鼻炎（AR）是一种常见的慢性疾病，以鼻膜炎症为特征。炎症和上皮屏障功能障碍在变应性疾病的发病机制中起重要作用。方法纳入88例AR患儿和50例健康对照。我们测量了血清zonulin和haptoglobin水平并对两组进行了比较。结果AR患儿zonulin中位值高于健康儿童[分别为11（4.21-35.95）比8.81 (3.59-47.72)ng/mL] （p = 0.024）。AR患儿触珠蛋白/带蛋白比值中位数[7.91(0.46-31.93)]低于健康对照组[11.07 (0.77-74.37),p = 0.011]。结论儿童高血带蛋白水平和低血带蛋白/带蛋白比值与AR的相关性增强，提示AR患儿炎症加重、肠道通透性和减少氧化损伤的预防机制被破坏。

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Allergic rhinitis in children is associated with high serum levels of zonulin

Background

Allergic rhinitis (AR) is a common chronic disease characterised by nasal membrane inflammation. Inflammation and epithelial barrier dysfunction play significant roles in the pathogenesis of allergic diseases.

Methods

The study included 88 children with AR and 50 healthy controls. We measured serum zonulin and haptoglobin levels and compared the groups.

Results

Children with AR had a higher median value of zonulin than healthy children [(11 (4.21–35.95) vs. 8.81 (3.59–47.72) ng/mL, respectively] (p = 0.024). Median value of haptoglobin/zonulin ratio was lower in children with AR [7.91 (0.46–31.93)] compared to healthy controls [11.07 (0.77–74.37), p = 0.011)]. Serum zonulin, haptoglobin levels and the haptoglobin/zonulin ratio did not differ significantly between children with persistent and intermittent AR.

Conclusion

High serum zonulin levels and low haptoglobin/zonulin ratios in children show an increased association with AR. Our results may support that inflammation is increased, intestinal permeability and preventive mechanisms to decrease oxidative damage are disrupted in children with AR.

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来源期刊

International journal of pediatric otorhinolaryngology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.70%

发文量

276

审稿时长

62 days

期刊介绍： The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.