International psychogeriatrics最新文献

{"title":"Apathy is distinct from depression or fatigue and is associated with poor physical health in an older community cohort.","authors":"Fleur Harrison, Moyra E Mortby, Andrew R Lloyd, Adam J Guastella, Julian N Trollor, Perminder S Sachdev, Henry Brodaty","doi":"10.1016/j.inpsyc.2025.100089","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100089","url":null,"abstract":"<p><strong>Objectives: </strong>To estimate point prevalence of apathy in older adults, examine its overlap with depression and fatigue, and explore its associations with multimorbidity and objective markers of health.</p><p><strong>Design: </strong>Sydney Memory and Ageing Study, an Australian population-based cohort.</p><p><strong>Setting: </strong>Community dwellings between 2005-2007.</p><p><strong>Participants: </strong>1,030 older adults, without dementia, aged 70-90.</p><p><strong>Measurements: </strong>Apathy was classified using strict (=3) and standard (≥2) cutoff scores on the self-report Geriatric Depression Scale (GDS)-3A, and a validated cutoff score (>0) on the informant-report Neuropsychiatric Inventory. Depression was assessed with strict and standard cutoffs on the GDS-12D, and fatigue with the Assessment of Quality of Life-6D. Multimorbidity (≥2 chronic conditions; computed with and without cardiovascular conditions), physical performance (walking speed, sit-to-stand, lateral stability, grip strength), adiposity (BMI, waist circumference), blood pressure, cholesterol and glucose were assessed.</p><p><strong>Results: </strong>Prevalence of apathy on the self-reported measure was 15.8 % (strict cutoff) or 48.9 % (standard). Informant-reported apathy was lower (2.9 %). Prevalence of self-reported depression was 5.9 % (strict cutoff) or 15.8 % (standard), and fatigue 9.8 %. Apathy overlapped very little with depression or fatigue (κ = .18, 95 % CI .14-.21). Apathy was associated with multimorbidity (even when excluding cardiovascular conditions), adiposity, fasting blood glucose level and physical performance, but not blood pressure or cholesterol.</p><p><strong>Conclusions: </strong>Apathy is more common than depression or fatigue in dementia-free older adults. It does not typically co-occur with these symptoms, but is accompanied by poorer physical health, including multimorbidity and metabolic dysregulation. Apathy may be relevant for public health and an important consideration in clinical care.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100089"},"PeriodicalIF":4.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musical Engagement of brain LObes in Alzheimer's Disease patients study (MELODY): A randomized controlled trial.","authors":"Jacobo Mintzer, Rebecca Long, Arianne Fritts, Jane Joseph, Paul J Nietert, Noam Calev, Olga Brawman-Mintzer","doi":"10.1016/j.inpsyc.2025.100087","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100087","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the effect of music exposure on global clinical impact, arousal, and brain network connectivity in subjects with moderate to severe Alzheimer's disease (AD).</p><p><strong>Design: </strong>This was a pilot, controlled, single-blind, randomized, cross-over study.</p><p><strong>Setting: </strong>The University Hospital Outpatient Clinic and Imaging Center and the Veterans Administration Research Facility.</p><p><strong>Participants: </strong>Ten participants aged between 55 and 90 years with moderate to severe AD, a Mini-Mental State Examination (MMSE) score of 5-20, and without neuropsychiatric symptoms of dementia were enrolled in the study.</p><p><strong>Intervention: </strong>Participants were exposed to both preferred music (PM) and nature sounds (NS). A randomization program was used to determine assignment order for either PM or NS to be delivered via over-ear headphones at Visit 1. Visit 2, which occurred approximately one week later, was identical to Visit 1, but the participants who were originally exposed to PM were exposed to NS and vice versa.</p><p><strong>Measurements: </strong>A modified version of the Alzheimer's Disease Cooperative Study Clinical Global Impression of Change (ADCS-CGIC) was the primary outcome measure and functional magnetic resonance imaging (fMRI) scans were used to evaluate brain network connectivity.</p><p><strong>Results: </strong>There was a clinically and statistically significant positive response to music stimulation in the primary outcome measure and in the secondary outcome measure, as well as a clear differentiation in brain network connectivity when individuals were exposed to PM versus NS. There was also a strong correlation between clinical changes and brain network connectivity changes as documented by fMRI.</p><p><strong>Conclusions: </strong>Music has the potential to be utilized as a non-invasive method to stimulate the brain of individuals with severe cognitive impairment in key functions TRIAL REGISTRATION: The trial was registered in ClinicalTrials.gov (ID: NCT05309369) by Jacobo Mintzer, MD, MBA.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100087"},"PeriodicalIF":4.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural network disruptions between default mode network and salience network in mild cognitive impairment with neuropsychiatric symptoms.","authors":"Chenxi Pan, Renren Li, Xiao Yuan, Jing Ma, Wei Zhang, Xiaoran Zheng, Zhilan Tu, Ying Su, Zhiyuan Zhai, Fuchun Lin, Yunxia Li","doi":"10.1016/j.inpsyc.2025.100092","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100092","url":null,"abstract":"<p><strong>Background: </strong>Neuropsychiatric symptoms (NPS) in mild cognitive impairment (MCI) are associated with accelerated Alzheimer's disease (AD) progression. Identifying multimodal brain imaging patterns associated with NPS in MCI may help understand pathophysiology correlates AD.</p><p><strong>Methods: </strong>This cross-sectional resting-state functional magnetic resonance imaging study included 376 participants: 130 MCI with neuropsychiatric symptoms (MCI+NPS), 154 MCI without neuropsychiatric symptoms (MCI-NPS), 92 cognitively normal (CN). NPS were assessed by the Neuropsychiatric Inventory Questionnaire (NPI-Q). Functional connectivity between default mode network (DMN) and salience network (SN) was compared among MCI+NPS, MCI-NPS and CN. Then, the morphometric measurements of abnormal node in default mode and salience networks was explored. Furthermore, correlation analysis was performed to investigate the relationship between NPS and functional and structural alterations in DMN and SN in MCI.</p><p><strong>Results: </strong>In the MCI+NPS group, the most frequently endorsed NPS was anxiety (46.2 %), the less prevalent NPS was euphoria/elation (1.44 %). Compared with the MCI-NPS group, there was abnormal FC between medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC) (P < 0.05) in the MCI+NPS group, which was significantly associated with total NPI-Q score (r = 0.244, p = 0.000), affective symptoms (r = 0.212, p = 0.000), and hyperactivity symptoms (r = 0.196 p = 0.000). The mPFC area of MCI-NPS group was smaller than that of CN group (p < 0.05), and the area of mPFC was significantly associated with hyperactivity symptoms in MCI group.</p><p><strong>Conclusions: </strong>Dysfunction of DMN and SN may partly contribute to the NPS in MCI patients, especially affective symptoms and hyperactivity symptoms. Our results complement the evidence linking NPS with Alzheimer's disease biomarkers.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100092"},"PeriodicalIF":4.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of social interactions on mood in residents with dementia in green care farms: An observational study using ecological momentary assessments.","authors":"Laura Frissen, Sil Aarts, Katharina Rosteius, Bram de Boer, Andrea Gabrio, Hilde Verbeek","doi":"10.1016/j.inpsyc.2025.100091","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100091","url":null,"abstract":"<p><strong>Background: </strong>Social connections are important for the quality of life of individuals living with dementia. As dementia progresses, maintaining these connections becomes challenging: especially in nursing homes, social interactions are often reduced. Small-scale, homelike environments such as green care farms (GCFs) may provide opportunities to facilitate social interactions. However, research on the characteristics of social interactions and their effects on mood is limited in these settings. This paper explored social interactions and their impact on mood over time in individuals with dementia living in GCFs.</p><p><strong>Methods: </strong>This observational study used ecological momentary assessments to gather repeated measurement data on individuals' experiences in everyday environments. The data were collected for a total of 151 residents living at four GCFs in the Netherlands. The residents' social interactions and mood were assessed using the Maastricht Electronic Daily Life Observation Tool (n = 4868 observations).</p><p><strong>Results: </strong>Social interactions occurred in less than half of the observations, indicating that residents spent the other half of their day without social interactions. The most common interactions included one resident and another person (e.g., staff members or other residents); these interactions were primarily positive. Overall, having social interactions was significantly related to a higher mood. However, social interactions did not have a significant effect on subsequent mood.</p><p><strong>Conclusions: </strong>The results highlight the importance of social interactions for residents' mood. Long-term care organizations should facilitate opportunities for meaningful social interaction to support the immediate mood and thus the well-being of residents with dementia.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100091"},"PeriodicalIF":4.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response for: Possible errors in \"Electroconvulsive therapy in individuals with dementia/major NCD presenting with behavioral symptoms: A systematic review\" [Int Psychogeriatr 36 (2024) 864-879].","authors":"Anil K Bachu, Vijaya Padma Kotapati, Tejasvi Kainth, Rikinkumar Patel, Nagy A Youssef, Rajesh R Tampi","doi":"10.1016/j.inpsyc.2025.100084","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100084","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100084"},"PeriodicalIF":4.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dementia training for healthcare professionals: A systematic policy and evidence review.","authors":"Sedigheh Zabihi, Saskia Delray, Malvika Muralidhar, Sube Banerjee, Clarissa Giebel, Karen Harrison Dening, Yvonne Birks, Rachael Hunter, Mohammed Akhlak Rauf, Charlotte Kenten, Madeleine Walpert, Claudia Cooper","doi":"10.1016/j.inpsyc.2025.100088","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100088","url":null,"abstract":"<p><strong>Objective: </strong>To review the effectiveness of healthcare professionals' dementia training and consider implications for policy and practice.</p><p><strong>Design: </strong>Systematic and policy review SETTING: Healthcare services PARTICIPANTS: Healthcare professionals INTERVENTION: Training MEASUREMENTS: We searched electronic databases for primary research studies (2015-2024) evaluating dementia training for healthcare professionals. We assessed risk of bias using the Mixed Methods Appraisal Tool, prioritising studies scoring 4 + , of interventions supported by Randomised Controlled Trial evidence; reporting outcomes using Kirkpatrick's framework. To explore how evidence might translate to practice, using England as a case study, we reviewed relevant policies and consulted professional stakeholders.</p><p><strong>Results: </strong>We reviewed 63 primary research studies. One met priority criteria; it evaluated a Train-the-Trainer (TTT), team-based reflective practice model, which improved primary care nurses' and doctors' learning, and self-reported practice over ≥ 3 months. Higher quality, controlled studies evaluated a TTT programme for hospital staff, improving client outcomes (agitation) over ≤ 5 days; an expert-led two-day interactive training for inpatient nurses that reduced role strain; and expert-led, nine-week, occupational therapy-derived training programme that improved retirement community staff strategies for client activity engagement. Sixteen policies and related documents highlighted concerns about limited implementation of the Dementia Core Skills Education and Training Framework (DCSETF). Eight focus group attendees considered time a limiting factor to evidence implementation, but valued group training to share experiences; and TTT models to enable tailoring to local contexts.</p><p><strong>Conclusions: </strong>By increasing reach of dementia training and embedding learning in practice, Train-the-Trainer models can increase care quality and support evidence-based policy implementation.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100088"},"PeriodicalIF":4.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzodiazepine prescription and cognitive impairment: A risk assessment.","authors":"Tomoyuki Kawada","doi":"10.1016/j.inpsyc.2025.100085","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100085","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100085"},"PeriodicalIF":4.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Dr. Kawada.","authors":"Esther Teverovsky","doi":"10.1016/j.inpsyc.2025.100086","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100086","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100086"},"PeriodicalIF":4.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis, evaluation & management of cognitive disorders in Parkinson's disease: A systematic review.","authors":"Dana Pourzinal, Charlotte Elgey, Daniel X Bailey, Jihyun Yang, Alexander Lehn, Helen Tinson, Jacki Liddle, Deborah Brooks, Sharon L Naismith, Kirstine Shrubsole, Rodney Marsh, Leander K Mitchell, Nancy A Pachana, James King, Nadeeka N Dissanayaka","doi":"10.1016/j.inpsyc.2025.100081","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100081","url":null,"abstract":"<p><strong>Background: </strong>There is considerable variability in the diagnosis, evaluation and management of cognitive disorders in Parkinson's disease (PD) across clinical services. A review of guidelines and relevant literature will provide recommendations to guide clinical decision-making. The present review aimed to summarise and critically appraise current recommendations for the diagnosis, evaluation and management of cognitive disorders in PD.</p><p><strong>Method: </strong>Five academic databases (PubMed, SCOPUS, Medline, PsycINFO, CINAHL) and five grey literature databases were systematically searched in August 2024 by two independent reviewers following PRISMA guidelines. Guidelines and systematic reviews from 2003-2024 available in English and reporting at least one relevant recommendation for the diagnosis, evaluation or management of cognitive disorders in PD were included. Quality assessment was completed using the AGREE-II tool for guidelines and AMSTAR tool for systematic reviews.</p><p><strong>Results: </strong>In total, 32 guidelines and 24 systematic reviews were included. Guideline quality ranged from moderate to high and systematic review quality from critically low to high. Articles provided recommendations for cognitive impairment in PD in terms of diagnosis, neuropsychological evaluation, treatment and care. However, recommendations for cognitive tools, care considerations, and non-pharmacological interventions were limited, despite relevant evidence from the systematic review literature.</p><p><strong>Conclusion: </strong>Significant gaps identified in processes for neuropsychological evaluations, inconsistent recommendations for non-pharmacological interventions, and limited care considerations calls for future iterations of the clinical practice guidelines for cognitive impairment in PD.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100081"},"PeriodicalIF":4.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective memory complaints at age 90 + in relation to cognition and risk of incident dementia: The 90 + Study.","authors":"Zarui A Melikyan, Colette Aguirre, Zeinah Al-Darsani, Katherine A Colcord, Annlia Paganini-Hill, Sarah E Tomaszewski Farias, Luohua Jiang, Claudia H Kawas, María M Corrada","doi":"10.1016/j.inpsyc.2025.100083","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100083","url":null,"abstract":"<p><strong>Background and aims: </strong>Associations of Subjective Memory Complaints (SMC) with cognition and future dementia are poorly understood in the oldest old (age 90 +), who have high incidence and prevalence of cognitive impairment. This study aims to (1) report SMC frequency, (2) assess cross-sectional associations between SMC and cognitive test scores, and (3) compare the abilities of SMC, Mini-mental state examination (MMSE), and cognitive diagnosis to predict dementia in the oldest old.</p><p><strong>Method: </strong>The 90 + Study participants without baseline dementia and with baseline SMC, MMSE, at least one other cognitive test, and cognitive diagnosis were included in cross-sectional analysis. A subset of this group with follow-up cognitive diagnosis was included in longitudinal analysis. Cross-sectional association between SMC and cognitive test scores was explored using linear regression. Risk of incident dementia in relation to baseline SMC, MMSE, and cognitive diagnosis was explored using three Cox regression models. Concordance Index (C-index) was used to compare model performance.</p><p><strong>Results: </strong>In 893 participants with average age 93 years (range 90-102), 43 % had SMC. Cross-sectionally, SMC were associated with lower scores on memory, language, executive function. After 3.5 years of follow-up (range 0.4-16), 325 of 789 participants developed dementia. SMC, compared with no SMC, was associated with twice the risk of incident dementia (HR=2.16, 95 %CI, 1.72-2.72; p < 0.01). SMC predicted incident dementia as well as MMSE (p = 0.12), but not as well as cognitive diagnosis (p < 0.01).</p><p><strong>Conclusions: </strong>Single SMC question might be useful to identify oldest old with cognitive impairment or at risk of dementia.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100083"},"PeriodicalIF":4.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}