International psychogeriatrics最新文献_第4页

Impact of psychotropic medications on cognition among older adults: a systematic review. 精神药物对老年人认知能力的影响：一项系统综述。

IF 4.6 2区医学

International psychogeriatrics Pub Date : 2024-12-01 Epub Date: 2023-10-20 DOI: 10.1017/S1041610223000844

Susmita Chandramouleeshwaran, Waqas U Khan, Fiona Inglis, Tarek K Rajji

{"title":"Impact of psychotropic medications on cognition among older adults: a systematic review.","authors":"Susmita Chandramouleeshwaran, Waqas U Khan, Fiona Inglis, Tarek K Rajji","doi":"10.1017/S1041610223000844","DOIUrl":"10.1017/S1041610223000844","url":null,"abstract":"Objectives: The aim of this systematic review is to examine the cognitive impact of psychotropic medications including benzodiazepines, antidepressants, mood stabilizers, antipsychotics, or a combination of these drugs on older adults.Design: Systematic review.Setting: We searched Medline, PsycINFO, and Embase through the Ovid platform, CINAHL through EBSCO, and Web of Science.Participants and interventions: Randomized control trials (RCTs) and cohort studies that used a validated scale to measure cognition with a follow-up period of at least six months were included.Measurement: The primary outcome of interest was cognitive change associated with psychotropic medication use.Results: A total of 7551 articles were identified from the primary electronic literature search across the five databases after eliminating duplicates. Based on full-text analysis, 27 articles (two RCTs, 25 cohorts) met the inclusion criteria. Of these, nine each examined the impact of benzodiazepines and antidepressants, five examined psychotropic combinations, three on antipsychotic drugs, and one on the effects of mood stabilizers.Conclusions: This is the first systematic review to examine the cognitive impact of multiple psychotropic drug classes in older adults over an extended follow-up period (six months or more) using robust sample sizes, drug-free control groups, and validated cognitive instruments. We found evidence to indicate cognitive decline with the cumulative use of benzodiazepines and the use of antidepressants, especially those with anticholinergic properties among older adults without cognitive impairment at baseline. Further, the use of antipsychotics and psychotropic combinations is also associated with cognitive decline in older adults.","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1110-1127"},"PeriodicalIF":4.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early prediction of mastery of a computerized functional skills training program in participants with mild cognitive impairment. 对轻度认知障碍参与者掌握计算机化功能技能训练计划的早期预测。

IF 4.6 2区医学

International psychogeriatrics Pub Date : 2024-12-01 Epub Date: 2024-02-21 DOI: 10.1017/S1041610224000115

Philip D Harvey, Courtney Dowell-Esquivel, Justin E Macchiarelli, Alejandro Martinez, Peter Kallestrup, Sara J Czaja

{"title":"Early prediction of mastery of a computerized functional skills training program in participants with mild cognitive impairment.","authors":"Philip D Harvey, Courtney Dowell-Esquivel, Justin E Macchiarelli, Alejandro Martinez, Peter Kallestrup, Sara J Czaja","doi":"10.1017/S1041610224000115","DOIUrl":"10.1017/S1041610224000115","url":null,"abstract":"Background: Cognition in MCI has responded poorly to pharmacological interventions, leading to use of computerized training. Combining computerized cognitive training (CCT) and functional skills training software (FUNSAT) produced improvements in 6 functional skills in MCI, with effect sizes >0.75. However, 4% of HC and 35% of MCI participants failed to master all 6 tasks. We address early identification of characteristics that identify participants who do not graduate, to improve later interventions.Methods: NC participants (n = 72) received FUNSAT and MCI (n = 92) participants received FUNSAT alone or combined FUNSAT and CCT on a fully remote basis. Participants trained twice a week for up to 12 weeks. Participants \"graduated\" each task when they made one or fewer errors on all 3-6 subtasks per task. Tasks were no longer trained after graduation.Results: Between-group comparisons of graduation status on baseline completion time and errors found that failure to graduate was associated with more baseline errors on all tasks but no longer completion times. A discriminant analysis found that errors on the first task (Ticket purchase) uniquely separated the groups, F = 41.40, p < .001, correctly classifying 94% of graduators. An ROC analysis found an AUC of .83. MOCA scores did not increase classification accuracy.Conclusions: More baseline errors, but not completion times, predicted failure to master all FUNSAT tasks. Accuracy of identification of eventual mastery was exceptional. Detection of risk to fail to master training tasks is possible in the first 15 minutes of the baseline assessment. This information can guide future enhancements of computerized training.","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1182-1193"},"PeriodicalIF":4.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computerized cognitive remediation of Long COVID in older adults. 对老年人进行长 COVID 计算机认知矫正。

IF 4.6 2区医学

International psychogeriatrics Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1017/S1041610224000139

Cutter A Lindbergh, Roger Altizer, James J Grady, Breno S Diniz, Jayesh Kamath, David C Steffens, Sarah Shizuko Morimoto

引用次数: 0

Importance of social functioning for older adults in the communities, the facilities, the clinics, and in the future.

IF 4.6 2区医学

International psychogeriatrics Pub Date : 2024-12-01 DOI: 10.1017/S1041610224000577

Asuna Arai, Takashi Ozaki, Yuriko Katsumata

引用次数: 0

Is incident cancer in later life associated with lower incidence of dementia? 晚年患癌症是否与痴呆症发病率较低有关？

IF 4.6 2区医学

International psychogeriatrics Pub Date : 2024-12-01 Epub Date: 2023-01-03 DOI: 10.1017/S1041610222001119

Osvaldo P Almeida, Graeme J Hankey, Bu B Yeap, Jonathan Golledge, Christopher Etherton-Beer, Suzanne Robinson, Leon Flicker

引用次数: 0

Effects of age on the relationship between sleep quality and cognitive performance: Findings from the Human Connectome Project-Aging cohort. 年龄对睡眠质量和认知表现之间关系的影响:来自人类连接体项目衰老队列的研究结果。

IF 4.6 2区医学

International psychogeriatrics Pub Date : 2024-12-01 Epub Date: 2023-12-04 DOI: 10.1017/S1041610223000911

Daniel E Cohen, Hyun Kim, Alina Levine, Davangere P Devanand, Seonjoo Lee, Terry E Goldberg

{"title":"Effects of age on the relationship between sleep quality and cognitive performance: Findings from the Human Connectome Project-Aging cohort.","authors":"Daniel E Cohen, Hyun Kim, Alina Levine, Davangere P Devanand, Seonjoo Lee, Terry E Goldberg","doi":"10.1017/S1041610223000911","DOIUrl":"10.1017/S1041610223000911","url":null,"abstract":"Background: The association between sleep quality and cognition is widely established, but the role of aging in this relationship is largely unknown.Objective: To examine how age impacts the sleep-cognition relationship and determine whether there are sensitive ranges when the relationship between sleep and cognition is modified. This investigation could help identify individuals at risk for sleep-related cognitive impairment.Subjects: Sample included 711 individuals (ages 36.00-89.83, 59.66 ± 14.91, 55.7 % female) from the Human Connectome Project-Aging (HCP-A).Methods: The association between sleep quality (Pittsburgh Sleep Quality Index, PSQI) and cognition (Crystallized Cognition Composite and Fluid Cognition Composite from the NIH Toolbox, the Trail Making Test, TMT, and the Rey Auditory Verbal Learning Test, RAVLT) was measured using linear regression models, with sex, race, use of sleep medication, hypertension, and years of education as covariates. The interaction between sleep and age on cognition was tested using the moderation analysis, with age as both continuous linear and nonlinear (quadratic) terms.Results: There was a significant interaction term between the PSQI and nonlinear age term (age2) on TMT-B (p = 0.02) and NIH Toolbox crystallized cognition (p = 0.02), indicating that poor sleep quality was associated with worse performance on these measures (sensitive age ranges 50-75 years for TMT-B and 66-70 years for crystallized cognition).Conclusions: The sleep-cognition relationship may be modified by age. Individuals in the middle age to early older adulthood age band may be most vulnerable to sleep-related cognitive impairment.","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1171-1181"},"PeriodicalIF":4.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138477690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic challenges and disparities in young-onset dementia: insights from a Southeast London memory clinic study.

IF 4.6 2区医学

International psychogeriatrics Pub Date : 2024-12-01 DOI: 10.1017/S1041610224000073

Latha Velayudhan, Christoph Mueller

引用次数: 0

Study rationale and baseline data for pilot trial of dronabinol adjunctive treatment of agitation in Alzheimer's dementia (THC-AD).

IF 4.6 2区医学

International psychogeriatrics Pub Date : 2024-12-01 DOI: 10.1017/S1041610221001150

Leah M Cohen, Eleanor Ash, John D Outen, Ryan Vandrey, Halima Amjad, Marc Agronin, M Haroon Burhanullah, Patricia Walsh, James M Wilkins, Jeannie-Marie Leoutsakos, Milap A Nowrangi, David Harper, Paul B Rosenberg, Brent P Forester

{"title":"Study rationale and baseline data for pilot trial of dronabinol adjunctive treatment of agitation in Alzheimer's dementia (THC-AD).","authors":"Leah M Cohen, Eleanor Ash, John D Outen, Ryan Vandrey, Halima Amjad, Marc Agronin, M Haroon Burhanullah, Patricia Walsh, James M Wilkins, Jeannie-Marie Leoutsakos, Milap A Nowrangi, David Harper, Paul B Rosenberg, Brent P Forester","doi":"10.1017/S1041610221001150","DOIUrl":"https://doi.org/10.1017/S1041610221001150","url":null,"abstract":"Agitation is a common complication of Alzheimer's dementia (Agit-AD) associated with substantial morbidity, high healthcare service utilization, and adverse emotional and physical impact on care partners. There are currently no FDA-approved pharmacological treatments for Agit-AD. We present the study design and baseline data for an ongoing multisite, three-week, double-blind, placebo-controlled, randomized clinical trial of dronabinol (synthetic tetrahydrocannabinol [THC]), titrated to a dose of 10 mg daily, in 80 participants to examine the safety and efficacy of dronabinol as an adjunctive treatment for Agit-AD. Preliminary findings for 44 participants enrolled thus far show a predominately female, white sample with advanced cognitive impairment (Mini Mental Status Examination mean 7.8) and agitation (Neuropsychiatric Inventory-Clinician Agitation subscale mean 14.1). Adjustments to study design in light of the COVID-19 pandemic are described. Findings from this study will provide guidance for the clinical utility of dronabinol for Agit-AD. ClinicalTrials.gov Identifier: NCT02792257.","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 12","pages":"1245-1250"},"PeriodicalIF":4.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of psychotropic medications on cognition among older adults: a systematic review.

IF 4.6 2区医学

International psychogeriatrics Pub Date : 2024-12-01 DOI: 10.1017/S1041610223000844

Susmita Chandramouleeshwaran, Waqas U Khan, Fiona Inglis, Tarek K Rajji

{"title":"Impact of psychotropic medications on cognition among older adults: a systematic review.","authors":"Susmita Chandramouleeshwaran, Waqas U Khan, Fiona Inglis, Tarek K Rajji","doi":"10.1017/S1041610223000844","DOIUrl":"https://doi.org/10.1017/S1041610223000844","url":null,"abstract":"Objectives: The aim of this systematic review is to examine the cognitive impact of psychotropic medications including benzodiazepines, antidepressants, mood stabilizers, antipsychotics, or a combination of these drugs on older adults.Design: Systematic review.Setting: We searched Medline, PsycINFO, and Embase through the Ovid platform, CINAHL through EBSCO, and Web of Science.Participants and interventions: Randomized control trials (RCTs) and cohort studies that used a validated scale to measure cognition with a follow-up period of at least six months were included.Measurement: The primary outcome of interest was cognitive change associated with psychotropic medication use.Results: A total of 7551 articles were identified from the primary electronic literature search across the five databases after eliminating duplicates. Based on full-text analysis, 27 articles (two RCTs, 25 cohorts) met the inclusion criteria. Of these, nine each examined the impact of benzodiazepines and antidepressants, five examined psychotropic combinations, three on antipsychotic drugs, and one on the effects of mood stabilizers.Conclusions: This is the first systematic review to examine the cognitive impact of multiple psychotropic drug classes in older adults over an extended follow-up period (six months or more) using robust sample sizes, drug-free control groups, and validated cognitive instruments. We found evidence to indicate cognitive decline with the cumulative use of benzodiazepines and the use of antidepressants, especially those with anticholinergic properties among older adults without cognitive impairment at baseline. Further, the use of antipsychotics and psychotropic combinations is also associated with cognitive decline in older adults.","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 12","pages":"1110-1127"},"PeriodicalIF":4.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is incident cancer in later life associated with lower incidence of dementia?

IF 4.6 2区医学

International psychogeriatrics Pub Date : 2024-12-01 DOI: 10.1017/S1041610222001119

Osvaldo P Almeida, Graeme J Hankey, Bu B Yeap, Jonathan Golledge, Christopher Etherton-Beer, Suzanne Robinson, Leon Flicker

引用次数: 0