International psychogeriatrics最新文献

{"title":"Ageism, ableism, and their intersection: Evidence from the Longitudinal Ageing Study in India wave 1.","authors":"Sayani Das, Liat Ayalon","doi":"10.1016/j.inpsyc.2025.100104","DOIUrl":"10.1016/j.inpsyc.2025.100104","url":null,"abstract":"<p><strong>Objectives: </strong>Ageism and ableism significantly affect the well-being, social inclusion, and access to resources of older adults, often shaped by socio-cultural factors, yet remain underexplored within the heterogeneous context of India. This study examines the prevalence and associated factors of ageism, ableism, and their intersection among older adults in India.</p><p><strong>Design, setting, participants, & measurements: </strong>Utilizing data from the Longitudinal Aging Study in India (LASI) Wave 1, this study analyzed responses from 30,728 community-dwelling older adults (aged 60 +) across all states and union territories. Participants were categorized into four groups: ageism, ableism, intersection, or none, based on their everyday experiences of discrimination related to age, physical disability, or both. Multinomial logistic regression identified sociodemographic factors associated with these discriminations, with the cumulative advantage/disadvantage theory serving as conceptual framework.</p><p><strong>Results: </strong>The weighted prevalence of ageism was 10.3 %, ableism was 0.5 %, and 0.4 % reported both. Men were more likely to report ableism (AOR2.66) and intersectional discrimination (AOR2.03) but less likely to report ageism (AOR 0.89). Increasing age (AOR 1.24) and lower education (AOR1.48) were associated with ageism, while unemployment was linked to ableism (AOR2.07) and intersectional discrimination (AOR 2.21). Notably, participants in poorer health were more likely to report ageism (AOR 1.29), ableism (AOR 3.15), and intersectional discrimination (AOR 5.14) based on the Healthy Aging Index, compared to healthier participants.</p><p><strong>Conclusions: </strong>The findings highlight how different factors shape experiences of discrimination, underscoring the importance of adopting both individual and intersectional perspectives to effectively address these issues and design targeted interventions.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100104"},"PeriodicalIF":4.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-psychosis in later life as a risk factor for progressive cognitive decline: Findings from the IPA psychosis in neurodegenerative disease working group.","authors":"Byron Creese, Jeffrey Cummings, Corinne Fischer, Dilip Jeste, Manibou Ikeda, Kathryn Mills, Zahinoor Ismail, Clive Ballard","doi":"10.1016/j.inpsyc.2025.100094","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100094","url":null,"abstract":"<p><p>Pre-clinical Alzheimer's disease (AD) has traditionally been characterized by subtle cognitive deficits alongside biomarker changes. However, emerging evidence suggests a spectrum of neuropsychiatric changes, including apathy, affective disturbances, agitation, impulse control deficits, and psychosis, may precede cognitive decline. Late-onset psychotic disorders, such as Very Late-Onset Schizophrenia-Like Psychosis (VLOSLP), differ from pre-psychosis, the latter presenting with subtle symptoms and retained insight. These subtler late-life onset symptoms are associated with incident cognitive decline, particularly in APOE4 carriers. Screening with tools such as the Mild Behavioral Impairment Checklist (MBI-C) enables the standardisation of measurement, facilitating identification of at-risk individuals. Plasma biomarkers and neuropsychological assessments further aid diagnosis and risk stratification. Understanding the link between pre-psychosis and dementia-related psychosis will be crucial, as AD with psychosis is associated with a more aggressive disease course. Identifying and treating these individuals early may improve clinical outcomes and facilitate timely intervention with disease-modifying therapies. Moreover, there remains a need to better define in what circumstances treatment interventions are indicated and what those interventions should be.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100094"},"PeriodicalIF":4.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel psychoeducational intervention to promote well-being in older adult nursing home patients: Combining survey preferences with evidence-based practices in the design of a comprehensive curriculum.","authors":"Arielle Silbersweig, Cristina M Pritchett, Monica Gavaller, Hyungseok Oh, Rachel Hershenberg, Jocelyn Wise, Kendra Le, Emma Blythe, Adriana P Hermida","doi":"10.1016/j.inpsyc.2025.100093","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100093","url":null,"abstract":"<p><strong>Background: </strong>Older adults comprise an especially vulnerable population with unique challenges associated with aging. Current mental health interventions for this population focus on different important components of well-being but do not combine them into one curriculum that is widely accessible to those who could benefit. We have chosen 3 pillars (mindfulness, meaning in life, and social connection) and developed a comprehensive curriculum to be shared with others by combining survey preferences from our population sample with evidence-based practices from the literature including positive psychiatry and psychotherapy.</p><p><strong>Methods: </strong>Long-term care and subacute rehabilitation patients from 2 nursing homes in Atlanta were recruited to participate in a survey. Categorical frequency calculations were used to evaluate participant interest and logistical preferences. Ranked scores and distribution columns were used to evaluate course content.</p><p><strong>Results: </strong>100 participants completed the survey. 55.1 % expressed interest in attending this type of course. For class length, frequency, duration, and size, average preference was for 30 min, once a week, 2-4 weeks, and 6-10 people, respectively. Between pillars, preferences in order of priority were: meaning in life (ranked score 215), mindfulness (198), and social connection (157). The subtopics with the highest ranked scores within each pillar were: gratitude for life lived, emotional stability, and increasing opportunities for social connections.</p><p><strong>Conclusion: </strong>Based on survey results and the literature, we have developed a psychoeducational course to promote well-being in older adult nursing home patients. A curriculum syllabus complete with course description, learning objectives, weekly topics and timelines, materials needed, notes, and handouts is included with the manuscript.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100093"},"PeriodicalIF":4.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dementia, cognitive impairment in Nigerians aged 90 years or older: A 20-year follow up of survivors of Ibadan study of aging cohort.","authors":"Olusegun Baiyewu, Olufisayo Elugbadebo, Sujuan Gao, Michael L Cuccaro, Jeffery M Vance, Temitope H Farombi, Kathleen A Lane, Pedro Mena, Farid Rajabil, Rufus Akinyemi, Adesola Ogunniyi, Akin Ojagbemi, Agboola J Adigun, Hugh C Hendrie, Margaret A Pericak-Vance","doi":"10.1016/j.inpsyc.2025.100090","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100090","url":null,"abstract":"<p><strong>Objective: </strong>Studies of dementia involving the oldest old are few in Sub-Saharan Africa. Survivors of the Ibadan arm of the Indianapolis-Ibadan Dementia Project who were enrolled in 1992 or 2001 were re-examined between 2021 and 2022.</p><p><strong>Aim: </strong>To revisit these subjects and evaluate them for the presence of cognitive and functional impairment and assign diagnoses as relevant as well as determine factors that mitigate development of dementia and cognitive impairment and thus promote healthy aging.</p><p><strong>Design: </strong>Evaluation consisted of the CERAD neuropsychological battery, an informant interview, and a clinical examination by physicians with expertise in cognitive disorders of aging. Diagnoses were adjudicated by consensus between psychiatrists and neurologists using ICD-10 and DSM-IV criteria and diagnosis of Mild Cognitive Impairment based on the National Institute of Aging- criteria RESULT: One hundred and thirty-five of the original 4425 persons ever recruited were re-evaluated. Mean age was 93·0±2·8 years (range 89-106 years); 103 (76 %) were females, 29 (21 %) were diagnosed dementia, 25 (18 %) had AD, 44 (32·6 %) had diagnosis of Mild Cognitive Impairment (MCI) and 62 (45·9 %) were cognitively normal. Using logistic regression model for the combined dementia and MCI group with predictor variables collected during the 2001 evaluation wave, we found that cognitive score (Odds Ratio (OR)= 0·94, p = 0·024 (95 % CI:0.09-0.99), diastolic blood pressure (OR=1·04, p = 0·015 (95 % CI:1.01-1.07) and regular alcohol use (OR=0·42, p = 0·041(95 % CI:0.18-0.96) were associated with 20-year prevalence of cognitive impairment after adjusting for age, sex, and education. ApoE4 allele was neither a risk factor for dementia nor Cognitive Impairment in this cohort.</p><p><strong>Conclusion: </strong>Prevalence of cognitive impairment in this oldest old survivor cohort was associated with cognitive performance, diastolic blood pressure and regular use of alcohol 20 years before.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100090"},"PeriodicalIF":4.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging of psychosis, agitation, and affective disturbance in Alzheimer's disease, dementia with Lewy bodies, and mild cognitive impairment.","authors":"Hideki Kanemoto, Tetsuo Kashibayashi, Ryuichi Takahashi, Takashi Suehiro, Yuto Satake, Daiki Taomoto, Yoshihiro Chadani, Kenji Tagai, Shunichiro Shinagawa, Kazunari Ishii, Kenji Yoshiyama, Manabu Ikeda, Hiroaki Kazui","doi":"10.1016/j.inpsyc.2025.100059","DOIUrl":"10.1016/j.inpsyc.2025.100059","url":null,"abstract":"<p><strong>Objectives: </strong>This study identifies neuropsychiatric syndromes and investigates their relationship with neuroimaging in Alzheimer's disease dementia (AD), dementia with Lewy bodies (DLB), and mild cognitive impairment (MCI).</p><p><strong>Methods: </strong>Magnetic resonance imaging and perfusion single-photon emission computed tomography data were collected for 281, 68, and 180 patients with AD, DLB, and MCI, respectively, from three Japanese institutions. Neuropsychiatric Inventory was used for exploratory factor analysis in each group. Statistical Parametric Mapping was exploited to reveal the relationships between each factor score and cerebral volume or perfusion with age, sex, dementia severity, and the other factor scores as covariates.</p><p><strong>Results: </strong>Three factors (psychosis, agitation, and affective disturbance) were extracted for AD. For DLB, nighttime behavior and aberrant motor behavior were extracted as independent symptoms with the same three factors. Four factors (psychosis, agitation, anxiety, and apathy) were extracted for MCI. A positive relationship between agitation and cerebral volume in the left middle frontal gyri and left caudate was observed in AD. In DLB, agitation was positively correlated with cerebral perfusion in the left dominant regions, including the middle frontal gyri and caudate. Psychosis and perfusion were negatively correlated in the left extent regions, including the temporo-parieto-occipital lobe, insula, and inferior frontal gyri in DLB. Psychosis was significantly associated with lower perfusion in the bilateral occipital lobes, whereas apathy was significantly correlated with a lower volume of the right dominant bilateral frontal lobes in MCI.</p><p><strong>Conclusions: </strong>Three neuropsychiatric syndromes - psychosis, agitation, and affective disturbance - may heterogeneously associate with AD, DLB, and MCI.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100059"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness of baseline functioning and sensitivity to improvement in older people with and without mild cognitive impairment receiving a computerized functional skills training program.","authors":"Philip D Harvey, Anna Strassnig, Martin T Strassnig, Andrea Rivera-Molina, Annalee Mueller, Colin A Depp, Raeanne C Moore, Peter Kallestrup, Sara J Czaja","doi":"10.1016/j.inpsyc.2024.100025","DOIUrl":"10.1016/j.inpsyc.2024.100025","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the relative ability of participants with Mild Cognitive Impairment (MCI) to self-assess their cognitive performance and training gains.</p><p><strong>Design: </strong>Randomized clinical trial with baseline and post treatment objective and self -report assessments.</p><p><strong>Setting: </strong>Multiple community centers in New York City and South Florida.</p><p><strong>Participants: </strong>MCI (n = 84) participants and individuals with normal cognition NC (n = 68).</p><p><strong>Intervention: </strong>MCI participants were randomized to receive fully remote functional skills training (FUNSAT) alone or with Computerized Cognitive Training (CCT), while NC participants received FUNSAT alone twice a week for up to 12 weeks.</p><p><strong>Measurements: </strong>Gains in performance of trained functional skills, performance-based assessments of cognition and functional capacity, and global and specific self-reports of functional abilities.</p><p><strong>Results: </strong>Baseline performance for all performance-based variables was significantly worse in the MCI participants, all p < .001, all d> .77. Training-related Improvements were found for all variables for both groups, all p < .001, all d> .54. However, baseline group differences in global and specific self-reports were smaller all p > .02, d< .44, than objective performance differences. Baseline reports of global functioning were correlated with baseline performance variables in both groups, although no self-reported changes in either global or specific self-reports were significant for either sample.</p><p><strong>Conclusions: </strong>Participants with MCI underestimated their performance deficits at baseline. Self-reports of changes in everyday functioning do not track the substantial objective changes. Previous studies have reported a lack of sensitivity to training gains in several different conditions. Strategies to increase awareness of training gains may be required to sustain treatment benefits.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"37 3","pages":"100025"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohen-mansfield agitation inventory total score as a measure of agitation and aggression in Alzheimer's disease: A factor analysis.","authors":"Suzanne B Hendrix, Mary Sano, Constantine Lyketsos, Paul B Rosenberg, Anton P Porsteinsson, Bruce L Brown, Dawson Hedges, Jeffrey L Cummings","doi":"10.1016/j.inpsyc.2025.100056","DOIUrl":"10.1016/j.inpsyc.2025.100056","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is often associated with agitation and aggression, which may impair function, impede care, and be a major source of stress for caregivers. The Cohen-Mansfield Agitation Inventory (CMAI) is often used to assess agitation and aggression. In its original, nursing-home version, it is a 29-item, caregiver-informed, clinician-administered 7-point scale that assesses the frequency of various agitation or aggressive behaviors. However, the instruction manual advises against the use of the total score in favor of a domain-based analysis. This recommendation has been followed in both clinical trials and practice. Because the CMAI is comprehensive and easy to administer, we sought to determine the validity of its total score as a single construct for assessing agitation and aggression in patients with AD.</p><p><strong>Methods: </strong>We used a previously conducted factor analysis of the CMAI scores from two risperidone trials in patients with dementia (N = 648), and a follow-up analysis of the subset of patients with psychosis of AD (N = 479), to examine, using vector analysis and an effect-size-versus-signal-to-noise ratio analysis, whether the total CMAI score could confidently be used as a global measure of agitation and aggression in AD.</p><p><strong>Results: </strong>Our findings suggest that the CMAI items from the dataset analyzed load into 4 clusters, which cover about 50 % of the total data variance. Surprisingly, items with the lowest signal-to-noise ratio (hitting, performing repetitious mannerisms, aimless pacing or wandering) had the strongest response to treatment (and vice versa), and belonged to different factors. The further observation that many items were spread among the factors, instead of primarily measuring a single factor or domain, suggests that there is a continuum of symptoms, and separating them into domains requires separating very similar items that measure two or more domains.</p><p><strong>Conclusions: </strong>These findings suggest that assessing agitation and aggression via CMAI domains instead of the total score is likely to miss important behavioral signals. Using total CMAI score in clinical trials and practice, along with the assessment of individual items, is warranted.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100056"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild cognitive impairment and dementia: Recent findings on assessment, diagnosis, risk factors and predictors.","authors":"Alastair J Flint","doi":"10.1016/j.inpsyc.2025.100080","DOIUrl":"10.1016/j.inpsyc.2025.100080","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100080"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social health and prevention of dementia: Integration of human and mice studies.","authors":"Myrra Vernooij-Dassen, Isabelle F van der Velpen, Suzanne D Lanooij, Eddy A van der Zee, M Arfan Ikram, Wilhelmus H I M Drinkenburg, Andrea Costanzo, Meike W Vernooij, Ulrich L M Eisel, René Melis, Martien J H Kas, Marieke Perry","doi":"10.1016/j.inpsyc.2025.100054","DOIUrl":"10.1016/j.inpsyc.2025.100054","url":null,"abstract":"<p><strong>Objectives: </strong>Prevention of dementia is considered a healthcare priority. We aimed to identify potentially modifiable risk factors and mechanisms within the social health domain to find novel avenues to prevent cognitive decline and dementia.</p><p><strong>Design: </strong>We integrated the results of eight sub-studies of the Social Health in Mice and Men (SHiMMy) project that were separately published in specialized journals, but not yet jointly considered. We followed the integrative methodology of Whittemore and Knafl, using the conceptual framework for social health to structure and integrate the results of human epidemiological and qualitative studies and experimental mice studies. This is a novel multi-method approach.</p><p><strong>Participants: </strong>Participants of the population-based longitudinal cohort Rotterdam study were included in the epidemiolocal studies (ranging from N = 1259 to N = 3.720) and in the qualitative study (n = 17). Mice intervention studies were performed using a transgenic mouse model for Alzheimer's pathology and matched controls, under group and single housed conditions.</p><p><strong>Measurements: </strong>Epidemiological studies include social health markers (loneliness, perceived social support, marital status) and magnetic resonance imaging of the brain. The semi-structured qualitative study used an interview guide. The mice study assessed behavioral and histological markers.</p><p><strong>Results: </strong>In human and mice studies, we identified several similar potentially modifiable risk (e.g. marital status, social group size) and protective (e.g. perceived social support, behavioral responses) factors. This alignment of findings showing that social health may impact brain health lend further support to our social health hypothesis.</p><p><strong>Conclusion: </strong>These results allow us to propose evidence-based social health targets for preventive interventions.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100054"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Clinical Outcomes of Patients with Diabetic Foot Infection Caused by Methicillin-Resistant <i>Staphylococcus Aureus</i> (MRSA) or Methicillin-Sensitive <i>Staphylococcus Aureus</i> (MSSA).","authors":"Francisco Javier Álvaro-Afonso, Esther García-Morales, Mateo López-Moral, Luis Alou-Cervera, Raúl Molines-Barroso, José Luis Lázaro-Martínez","doi":"10.1177/15347346221094994","DOIUrl":"10.1177/15347346221094994","url":null,"abstract":"<p><p>Few studies have addressed the interaction of specific pathogens with clinical outcomes in patients with diabetic foot infection (DFI). Our study aim was to compare the clinical outcomes among patients with DFI caused by methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) with cases caused by methicillin-sensitive <i>Staphylococcus aureus</i> (MSSA). We gathered the data of 75 consecutive patients admitted at specialized outpatients diabetic with mild or moderate DFI in which <i>S. aureus</i> was isolated from bone or soft tissue specimens in pure or as a part of the polymicrobial culture. Patients were divided into two groups: those with MRSA infection and those with MSSA infection. Patients with MRSA diabetic foot infections were significantly associated with male gender (86% vs. 64%, <i>P</i> = .029), higher SINBAD Classification Score (3.6 ± 0.99 points vs. 2.8 ± 1.06 points, <i>P</i> = .001), longer mean wound evolution [17.8 (3;29.5) weeks versus 9.1 (1;12) weeks, <i>P</i> = .008], bone involvement [18 (50%) versus 9 (23.1%), <i>P</i> = .015] and longer mean healing time [18.2(8;28) weeks versus 9.1 (1;12) weeks, <i>P</i> = .008]. In addition, male gender (OR 8.81, 95% CI 2.00-38.84) and SINBAD Classification Score (OR 2.70, 1.46-5.00) were identified as independent risk factors for MRSA DFI. Significant differences in the number of surgical procedures to resolve infection [15 (41.7%) versus 13 (33.3%), <i>P</i> = .456] or in the mean healing time after surgical treatment [10.5 weeks (6.7;16.5) versus 6.1 weeks (3;8.7), <i>P</i> = .068] were not observed among groups, suggesting that when treatment is based on early and surgical debridement, MRSA infections are not associated with worse prognosis. In conclusion MRSA DFI has importance in clinical outcomes such as time to healing. We propose that recent lines of research regarding the genetic virulence of strains of <i>S. aureus</i> could provide new insights into our results.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"14 1","pages":"392-401"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79103733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}