Olusegun Baiyewu, Olufisayo Elugbadebo, Sujuan Gao, Michael L Cuccaro, Jeffery M Vance, Temitope H Farombi, Kathleen A Lane, Pedro Mena, Farid Rajabil, Rufus Akinyemi, Adesola Ogunniyi, Akin Ojagbemi, Agboola J Adigun, Hugh C Hendrie, Margaret A Pericak-Vance
{"title":"90岁及以上尼日利亚人的痴呆、认知障碍：对伊巴丹衰老队列研究幸存者的20年随访","authors":"Olusegun Baiyewu, Olufisayo Elugbadebo, Sujuan Gao, Michael L Cuccaro, Jeffery M Vance, Temitope H Farombi, Kathleen A Lane, Pedro Mena, Farid Rajabil, Rufus Akinyemi, Adesola Ogunniyi, Akin Ojagbemi, Agboola J Adigun, Hugh C Hendrie, Margaret A Pericak-Vance","doi":"10.1016/j.inpsyc.2025.100090","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Studies of dementia involving the oldest old are few in Sub-Saharan Africa. Survivors of the Ibadan arm of the Indianapolis-Ibadan Dementia Project who were enrolled in 1992 or 2001 were re-examined between 2021 and 2022.</p><p><strong>Aim: </strong>To revisit these subjects and evaluate them for the presence of cognitive and functional impairment and assign diagnoses as relevant as well as determine factors that mitigate development of dementia and cognitive impairment and thus promote healthy aging.</p><p><strong>Design: </strong>Evaluation consisted of the CERAD neuropsychological battery, an informant interview, and a clinical examination by physicians with expertise in cognitive disorders of aging. Diagnoses were adjudicated by consensus between psychiatrists and neurologists using ICD-10 and DSM-IV criteria and diagnosis of Mild Cognitive Impairment based on the National Institute of Aging- criteria RESULT: One hundred and thirty-five of the original 4425 persons ever recruited were re-evaluated. Mean age was 93·0±2·8 years (range 89-106 years); 103 (76 %) were females, 29 (21 %) were diagnosed dementia, 25 (18 %) had AD, 44 (32·6 %) had diagnosis of Mild Cognitive Impairment (MCI) and 62 (45·9 %) were cognitively normal. Using logistic regression model for the combined dementia and MCI group with predictor variables collected during the 2001 evaluation wave, we found that cognitive score (Odds Ratio (OR)= 0·94, p = 0·024 (95 % CI:0.09-0.99), diastolic blood pressure (OR=1·04, p = 0·015 (95 % CI:1.01-1.07) and regular alcohol use (OR=0·42, p = 0·041(95 % CI:0.18-0.96) were associated with 20-year prevalence of cognitive impairment after adjusting for age, sex, and education. ApoE4 allele was neither a risk factor for dementia nor Cognitive Impairment in this cohort.</p><p><strong>Conclusion: </strong>Prevalence of cognitive impairment in this oldest old survivor cohort was associated with cognitive performance, diastolic blood pressure and regular use of alcohol 20 years before.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100090"},"PeriodicalIF":4.3000,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dementia, cognitive impairment in Nigerians aged 90 years or older: A 20-year follow up of survivors of Ibadan study of aging cohort.\",\"authors\":\"Olusegun Baiyewu, Olufisayo Elugbadebo, Sujuan Gao, Michael L Cuccaro, Jeffery M Vance, Temitope H Farombi, Kathleen A Lane, Pedro Mena, Farid Rajabil, Rufus Akinyemi, Adesola Ogunniyi, Akin Ojagbemi, Agboola J Adigun, Hugh C Hendrie, Margaret A Pericak-Vance\",\"doi\":\"10.1016/j.inpsyc.2025.100090\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Studies of dementia involving the oldest old are few in Sub-Saharan Africa. Survivors of the Ibadan arm of the Indianapolis-Ibadan Dementia Project who were enrolled in 1992 or 2001 were re-examined between 2021 and 2022.</p><p><strong>Aim: </strong>To revisit these subjects and evaluate them for the presence of cognitive and functional impairment and assign diagnoses as relevant as well as determine factors that mitigate development of dementia and cognitive impairment and thus promote healthy aging.</p><p><strong>Design: </strong>Evaluation consisted of the CERAD neuropsychological battery, an informant interview, and a clinical examination by physicians with expertise in cognitive disorders of aging. Diagnoses were adjudicated by consensus between psychiatrists and neurologists using ICD-10 and DSM-IV criteria and diagnosis of Mild Cognitive Impairment based on the National Institute of Aging- criteria RESULT: One hundred and thirty-five of the original 4425 persons ever recruited were re-evaluated. Mean age was 93·0±2·8 years (range 89-106 years); 103 (76 %) were females, 29 (21 %) were diagnosed dementia, 25 (18 %) had AD, 44 (32·6 %) had diagnosis of Mild Cognitive Impairment (MCI) and 62 (45·9 %) were cognitively normal. Using logistic regression model for the combined dementia and MCI group with predictor variables collected during the 2001 evaluation wave, we found that cognitive score (Odds Ratio (OR)= 0·94, p = 0·024 (95 % CI:0.09-0.99), diastolic blood pressure (OR=1·04, p = 0·015 (95 % CI:1.01-1.07) and regular alcohol use (OR=0·42, p = 0·041(95 % CI:0.18-0.96) were associated with 20-year prevalence of cognitive impairment after adjusting for age, sex, and education. ApoE4 allele was neither a risk factor for dementia nor Cognitive Impairment in this cohort.</p><p><strong>Conclusion: </strong>Prevalence of cognitive impairment in this oldest old survivor cohort was associated with cognitive performance, diastolic blood pressure and regular use of alcohol 20 years before.</p>\",\"PeriodicalId\":14368,\"journal\":{\"name\":\"International psychogeriatrics\",\"volume\":\" \",\"pages\":\"100090\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International psychogeriatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.inpsyc.2025.100090\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International psychogeriatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.inpsyc.2025.100090","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：在撒哈拉以南非洲，涉及老年痴呆症的研究很少。印第安纳波利斯-伊巴丹痴呆症项目伊巴丹分部的幸存者在1992年或2001年注册，他们在2021年至2022年期间重新接受了检查。目的：重新审视这些受试者，评估他们是否存在认知和功能障碍，并确定相关的诊断，以及确定减轻痴呆和认知障碍发展的因素，从而促进健康老龄化。设计：评估包括CERAD神经心理学测试、被调查者访谈和由具有老年认知障碍专业知识的医生进行的临床检查。诊断是由精神病学家和神经科医生使用ICD-10和DSM-IV标准和轻度认知障碍诊断基于国家老龄化研究所的标准进行的。结果：最初招募的4425人中有135人被重新评估。平均年龄93±2.8岁（89 ~ 106岁）；其中女性103例（76%），诊断为痴呆29例（21%），AD 25例（18%），轻度认知障碍44例（32.6%），认知正常62例（45.9%）。使用2001年评估波中收集的预测变量对痴呆和MCI合并组进行logistic回归模型，我们发现认知评分(优势比(OR)= 0.94, p = 0.024 （95% CI:0.09-0.99）、舒张压(OR= 1.04, p = 0.015 （95% CI:1.01-1.07）和定期饮酒(OR= 0.42, p = 0.041 （95% CI:0.18-0.96）与20年认知障碍患病率相关，经年龄、性别和教育调整后。ApoE4等位基因在该队列中既不是痴呆的危险因素，也不是认知障碍的危险因素。结论：在这个年龄最大的老年幸存者队列中，认知功能障碍的患病率与认知能力、舒张压和20年前的常规饮酒有关。
Dementia, cognitive impairment in Nigerians aged 90 years or older: A 20-year follow up of survivors of Ibadan study of aging cohort.
Objective: Studies of dementia involving the oldest old are few in Sub-Saharan Africa. Survivors of the Ibadan arm of the Indianapolis-Ibadan Dementia Project who were enrolled in 1992 or 2001 were re-examined between 2021 and 2022.
Aim: To revisit these subjects and evaluate them for the presence of cognitive and functional impairment and assign diagnoses as relevant as well as determine factors that mitigate development of dementia and cognitive impairment and thus promote healthy aging.
Design: Evaluation consisted of the CERAD neuropsychological battery, an informant interview, and a clinical examination by physicians with expertise in cognitive disorders of aging. Diagnoses were adjudicated by consensus between psychiatrists and neurologists using ICD-10 and DSM-IV criteria and diagnosis of Mild Cognitive Impairment based on the National Institute of Aging- criteria RESULT: One hundred and thirty-five of the original 4425 persons ever recruited were re-evaluated. Mean age was 93·0±2·8 years (range 89-106 years); 103 (76 %) were females, 29 (21 %) were diagnosed dementia, 25 (18 %) had AD, 44 (32·6 %) had diagnosis of Mild Cognitive Impairment (MCI) and 62 (45·9 %) were cognitively normal. Using logistic regression model for the combined dementia and MCI group with predictor variables collected during the 2001 evaluation wave, we found that cognitive score (Odds Ratio (OR)= 0·94, p = 0·024 (95 % CI:0.09-0.99), diastolic blood pressure (OR=1·04, p = 0·015 (95 % CI:1.01-1.07) and regular alcohol use (OR=0·42, p = 0·041(95 % CI:0.18-0.96) were associated with 20-year prevalence of cognitive impairment after adjusting for age, sex, and education. ApoE4 allele was neither a risk factor for dementia nor Cognitive Impairment in this cohort.
Conclusion: Prevalence of cognitive impairment in this oldest old survivor cohort was associated with cognitive performance, diastolic blood pressure and regular use of alcohol 20 years before.
期刊介绍：
A highly respected, multidisciplinary journal, International Psychogeriatrics publishes high quality original research papers in the field of psychogeriatrics. The journal aims to be the leading peer reviewed journal dealing with all aspects of the mental health of older people throughout the world. Circulated to over 1,000 members of the International Psychogeriatric Association, International Psychogeriatrics also features important editorials, provocative debates, literature reviews, book reviews and letters to the editor.
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