International psychogeriatrics最新文献

{"title":"The role of functional dependence in depressive symptoms among centenarians: Findings from the SWISS100 study.","authors":"Carla Gomes da Rocha, Daniela S Jopp, Adar Hoffman, Justine Falciola, Stefano Cavalli, François R Herrmann, Christina Röcke, Henk Verloo, Olga Ribeiro, Armin von Gunten","doi":"10.1016/j.inpsyc.2025.100071","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100071","url":null,"abstract":"<p><strong>Objective: </strong>To analyse the prevalence of depressive symptoms in centenarians, identify their predictors, and explore the role of functional dependence as a contributing factor.</p><p><strong>Design setting, and participants: </strong>Cross-sectional baseline data from the Swiss Centenarian Study (n = 102), including community-dwelling and institutionalised participants with complete data on depressive symptoms and functional capacity.</p><p><strong>Measurements: </strong>Functional capacity was assessed using the Older Americans Resources and Services Multidimensional Functional Assessment Questionnaire. Depressive symptoms were measured with the Geriatric Depression Scale - Short Form. Group differences were analysed using Chi-squared tests; relationships were examined with correlations. Multiple linear regressions identified predictors. Mediation analysis explored the interplay between functional capacity, living situation, and depressive symptoms.</p><p><strong>Results: </strong>Functional capacity varied, with basic activities of daily living generally better preserved than instrumental activities. Almost one-fourth of participants screened positive for possible clinical depression, which was significantly more common among institutionalised centenarians (p < .05). Health conditions, anxiety, and lower functional capacity were significant predictors of depressive symptoms and together explained 24.7 % of the variance, with anxiety being the strongest predictor followed by health conditions and functional capacity. Mediation analysis showed that functional capacity mediated the relationship between living situation and depressive symptoms, highlighting its critical role in mental health.</p><p><strong>Conclusions: </strong>A significant proportion of centenarians screened positive for depression, underscoring the need for greater attention to depressive symptoms and systematic screening. Targeted interventions promoting functional independence may play an important role to prevent depression, and strategies are needed to encourage institutionalised very old individuals to re-develop and maintain a certain level of independence.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100071"},"PeriodicalIF":4.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden and attributable risk factors of depressive disorders among older adults, 1990-2021.","authors":"Bingyi Wang, Chaohua Lan, Ke Liu, Leiwen Fu, Peng Zhang, Cailing Ao, Qiqiao Zhang, Qiongfang Wu, Fang Yang, Yan Li, Yong Lu, Xiaobing Fu","doi":"10.1016/j.inpsyc.2025.100069","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100069","url":null,"abstract":"<p><strong>Background: </strong>As a highly prevalent and disabling mental health condition among older adults, the epidemiology of depressive disorders could have evolved with global ageing. We aimed to assess the global, regional, and national burdens and trends of depressive disorders among older adults aged ≥ 55 years.</p><p><strong>Methods: </strong>We retrieved data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 on the incidence, prevalence and disability-adjusted life-years (DALYs) of depressive disorders for older adults. Estimated annual percentage changes were calculated to quantify the temporal trends.</p><p><strong>Results: </strong>In 2021, there were an estimated 93.1 million (95 % UI 80.4-108.5) older adults with depressive disorders globally, representing a substantial increase of 136.1 % from the 1990 estimates. The number of DALYs globally in 2021 was 14.8 million (10.3-20.1) for depressive disorders. The largest increase in DALYs was observed in High-income Asia Pacific, while the largest reduction was in Eastern Europe. In terms of risk factors, the corresponding estimated annual percentage change for intimate partner violence was -0.02 % (-0.11 to 0.07), and for childhood sexual abuse and bullying was -0.22 % (-0.30 to -0.14), from 1990 to 2021.</p><p><strong>Conclusions: </strong>For three decades, improved health conditions had not resulted in the expected decline in depressive disorders burdens among older adults, highlighting the need for health policy attention, especially in countries with low to medium Socio-demographic Index. It is important to align funding priorities with epidemiological shifts in low- and middle-income countries to mitigate depressive disorders burdens among this population.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100069"},"PeriodicalIF":4.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-review and synthesis of the effectiveness of psychosocial interventions for people living with dementia nearing the end of life and their family carers.","authors":"Nathan Davies, Yolanda Barrado-Martín, Jesutofunmi Aworinde, Victoria Vickerstaff, Kirsten Moore, Charlotte Kenten, Sarah McMullen, Catherine Evans, Elizabeth L Sampson","doi":"10.1016/j.inpsyc.2025.100068","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100068","url":null,"abstract":"<p><strong>Background: </strong>Dementia, is a leading cause of death internationally, affecting 55 million people. A palliative approach, emphasizing holistic and psychosocial care, is increasingly recognised as essential for addressing the complex needs of people with dementia and their carers. However, little research has explored the interface between psychosocial interventions for people with dementia near the end of life and palliative care, necessitating a synthesis to guide integrated, person-centred care.</p><p><strong>Aim: </strong>To establish a framework of evidence-based psychosocial interventions in dementia palliative care.</p><p><strong>Methods: </strong>We conducted a systematic review using narrative synthesis. Three electronic databases (Epistemonikos, MEDLINE and ASSIA) were searched (January 1980-May 2024), for systematic reviews, guided by the methods of Cochrane overview of reviews. This is part of a series of reviews with the focus for this manuscript on psychosocial interventions for people with dementia.</p><p><strong>Results: </strong>Thirty-four reviews were included, published between 2009 and 2023. No reviews of interventions covered all domains of dementia palliative care. The majority focussed on neuropsychiatric symptom management and promoting wellbeing. There were no reviews which covered managing care transitions, continuity of care and care co-ordination, or information for people with dementia.</p><p><strong>Conclusions: </strong>There is significant progress in the development and evaluation of interventions targeting behavioural and psychological symptoms of dementia (BPSD). However, a critical gap persists in addressing other essential aspects of quality of life and dementia care, with a notable gap in addressing many crucial aspects of palliative dementia care, such as care co-ordination, transitions, and carer support.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100068"},"PeriodicalIF":4.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in functional connectivity in individuals with subjective cognitive decline and hippocampal atrophy.","authors":"B Varela-López, M A Rivas-Fernández, M Zurrón, M Lindín, F Díaz, S Galdo-Alvarez","doi":"10.1016/j.inpsyc.2025.100067","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100067","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to determine whether individuals with Subjective Cognitive Decline (SCD), particularly those with a neurostructural marker of risk for AD (SCD+), exhibit differences in the functional connectivity of the Default-Mode Network (DMN) relative to controls, as this network is known to be altered in the AD continuum.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>Galicia, Northwest Spain.</p><p><strong>Participants: </strong>The sample compromised 133 participants: 69 controls, 51 SCD and 13 SCD+.</p><p><strong>Measurements: </strong>Seed-to-voxel analysis was conducted using four DMN ROIs. Dynamic independent component analysis of the DMN was also performed.</p><p><strong>Results: </strong>The SCD and SCD+ groups exhibited DMN hyperconnectivity, which was more extensive in the SCD+ group. Increased anti-correlations between DMN and task-positive parietal regions were related to poorer executive scores in SCD+ and a tendency for higher DMN recurrence in SCD+.</p><p><strong>Conclusions: </strong>Hippocampal atrophy as a SCD+ biomarker is associated with extensive DMN hyperconnectivity and increased anti-correlations between DMN and task-positive network regions.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100067"},"PeriodicalIF":4.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological characteristics and functional abilities in older adults with subjective cognitive complaints: A potential new target for early intervention.","authors":"Jaclyn M Fox, Danielle J Harvey, Christine N Pons, Yichu Chen, Samina Rahman, Michael J Ryan, Jagnoor Randhawa, Alyssa M Weakley, Michelle L Chan, Maureen Schmitter-Edgecombe, Sarah Tomaszewski Farias","doi":"10.1016/j.inpsyc.2025.100066","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100066","url":null,"abstract":"<p><strong>Objectives: </strong>Positive psychological characteristics may help to bolster daily functioning in older adults even in the presence of subjective or subtle objective cognitive weaknesses. The purpose of the present study was to examine which specific psychological characteristics may contribute to better functional abilities, independent of cognitive performance, among a sample of older adults with subjective cognitive decline (SCD).</p><p><strong>Design, setting, and participants: </strong>Participants included 277 older adults recruited from the community who were enrolled in a randomized controlled trial examining the impact of training in memory support strategies and healthy lifestyle behaviors. The current study was based on baseline data prior to intervention randomization.</p><p><strong>Measurements: </strong>Linear regression was used to assess associations between positive psychological characteristics (positive affect, life satisfaction, purpose in life, resiliency, self-management of health, and perceived competence), one negative psychological characteristic (negative affect), and functional abilities controlling for demographic variables. A final model assessed for associations between functional abilities and any of the significant characteristics identified in the linear regressions while controlling for global cognition (measured with the Modified Neuropsychological Test Battery composite score), depression, and demographic variables.</p><p><strong>Results: </strong>In the individual regressions, most of the psychological characteristics were significantly associated with functional abilities. In the final model, positive and negative affect remained significantly associated with functional abilities.</p><p><strong>Conclusions: </strong>This is one of the first studies to show that greater positive affect is associated with better functional abilities, even after controlling for objective cognitive performance. Positive affect in older adults may represent a modifiable target for intervention.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100066"},"PeriodicalIF":4.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging of psychosis, agitation, and affective disturbance in Alzheimer's disease, dementia with Lewy bodies, and mild cognitive impairment.","authors":"Hideki Kanemoto, Tetsuo Kashibayashi, Ryuichi Takahashi, Takashi Suehiro, Yuto Satake, Daiki Taomoto, Yoshihiro Chadani, Kenji Tagai, Shunichiro Shinagawa, Kazunari Ishii, Kenji Yoshiyama, Manabu Ikeda, Hiroaki Kazui","doi":"10.1016/j.inpsyc.2025.100059","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100059","url":null,"abstract":"<p><strong>Objectives: </strong>This study identifies neuropsychiatric syndromes and investigates their relationship with neuroimaging in Alzheimer's disease dementia (AD), dementia with Lewy bodies (DLB), and mild cognitive impairment (MCI).</p><p><strong>Methods: </strong>Magnetic resonance imaging and perfusion single-photon emission computed tomography data were collected for 281, 68, and 180 patients with AD, DLB, and MCI, respectively, from three Japanese institutions. Neuropsychiatric Inventory was used for exploratory factor analysis in each group. Statistical Parametric Mapping was exploited to reveal the relationships between each factor score and cerebral volume or perfusion with age, sex, dementia severity, and the other factor scores as covariates.</p><p><strong>Results: </strong>Three factors (psychosis, agitation, and affective disturbance) were extracted for AD. For DLB, nighttime behavior and aberrant motor behavior were extracted as independent symptoms with the same three factors. Four factors (psychosis, agitation, anxiety, and apathy) were extracted for MCI. A positive relationship between agitation and cerebral volume in the left middle frontal gyri and left caudate was observed in AD. In DLB, agitation was positively correlated with cerebral perfusion in the left dominant regions, including the middle frontal gyri and caudate. Psychosis and perfusion were negatively correlated in the left extent regions, including the temporo-parieto-occipital lobe, insula, and inferior frontal gyri in DLB. Psychosis was significantly associated with lower perfusion in the bilateral occipital lobes, whereas apathy was significantly correlated with a lower volume of the right dominant bilateral frontal lobes in MCI.</p><p><strong>Conclusions: </strong>Three neuropsychiatric syndromes - psychosis, agitation, and affective disturbance - may heterogeneously associate with AD, DLB, and MCI.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100059"},"PeriodicalIF":4.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohen-mansfield agitation inventory total score as a measure of agitation and aggression in Alzheimer's disease: A factor analysis.","authors":"Suzanne B Hendrix, Mary Sano, Constantine Lyketsos, Paul B Rosenberg, Anton P Porsteinsson, Bruce L Brown, Dawson Hedges, Jeffrey L Cummings","doi":"10.1016/j.inpsyc.2025.100056","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100056","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is often associated with agitation and aggression, which may impair function, impede care, and be a major source of stress for caregivers. The Cohen-Mansfield Agitation Inventory (CMAI) is often used to assess agitation and aggression. In its original, nursing-home version, it is a 29-item, caregiver-informed, clinician-administered 7-point scale that assesses the frequency of various agitation or aggressive behaviors. However, the instruction manual advises against the use of the total score in favor of a domain-based analysis. This recommendation has been followed in both clinical trials and practice. Because the CMAI is comprehensive and easy to administer, we sought to determine the validity of its total score as a single construct for assessing agitation and aggression in patients with AD.</p><p><strong>Methods: </strong>We used a previously conducted factor analysis of the CMAI scores from two risperidone trials in patients with dementia (N = 648), and a follow-up analysis of the subset of patients with psychosis of AD (N = 479), to examine, using vector analysis and an effect-size-versus-signal-to-noise ratio analysis, whether the total CMAI score could confidently be used as a global measure of agitation and aggression in AD.</p><p><strong>Results: </strong>Our findings suggest that the CMAI items from the dataset analyzed load into 4 clusters, which cover about 50 % of the total data variance. Surprisingly, items with the lowest signal-to-noise ratio (hitting, performing repetitious mannerisms, aimless pacing or wandering) had the strongest response to treatment (and vice versa), and belonged to different factors. The further observation that many items were spread among the factors, instead of primarily measuring a single factor or domain, suggests that there is a continuum of symptoms, and separating them into domains requires separating very similar items that measure two or more domains.</p><p><strong>Conclusions: </strong>These findings suggest that assessing agitation and aggression via CMAI domains instead of the total score is likely to miss important behavioral signals. Using total CMAI score in clinical trials and practice, along with the assessment of individual items, is warranted.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100056"},"PeriodicalIF":4.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between anxious-depression and cognitive change and mild cognitive impairment: HCHS/SOL Study of Latinos-Investigation of Neurocognitive Aging.","authors":"Natasha Z Anita, Roberto Gonzalez-Prado, Alejandra Morlett Paredes, Wassim Tarraf, Sayaka Kuwayama, Ariana M Stickel, Daniela Sotres-Alvarez, Linda C Gallo, Frank J Pendedo, Martha Daviglus, Fernando D Testai, Hector M González","doi":"10.1016/j.inpsyc.2025.100058","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100058","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined the associations between anxious-depression symptoms with cognitive change and prevalent mild cognitive impairment (MCI) in middle-aged and older Hispanics/Latinos.</p><p><strong>Methods: </strong>Participants were enrolled in the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) and the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Anxiety and depression were measured at Visit 1 using the 10-item Spielberger State-Trait Anxiety Inventory and the 10-item Center for Epidemiologic Studies Depression Scale, with latent class analysis applied to derive anxious-depression phenotypes based on items from both scales. Cognitive tests were completed at Visits 1 and 2 (average 7-years follow-up), where change was assessed using a change index between Visit 1 and 2, and function was assessed at Visit 2. Prevalent MCI was assessed using National Institute on Aging diagnostic criteria. Regression models were used to investigate the association of anxious-depression phenotypes with cognitive function, change, and MCI.</p><p><strong>Results: </strong>In 6140 participants (mean age = 56.5 ± 8.1-years), three anxious-depression profiles were identified: low (62 %), moderate (30 %), and high (8 %). All three profiles were associated with cognitive function at Visit 2, where high and moderate phenotypes were associated with lower cognitive scores compared to low. Moderate and high anxious-depression phenotypes were associated with greater prevalence of MCI compared to low (OR [95 % CI] = 1.64 [1.25; 2.16] and OR = 1.62 [1.12; 2.33], respectively). We found no associations between cognitive change and anxious-depression phenotype.</p><p><strong>Discussion: </strong>Co-occurring elevated anxiety and depression symptoms were associated with lower cognitive function and increased prevalence MCI 7-years later, but not overall changes in cognitive function between Visit 1 and Visit 2.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100058"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible errors in \"Electroconvulsive therapy in individuals with dementia/major NCD presenting with behavioral symptoms: A systematic review\" [Int Psychogeriatr 36 (2024) 864-879].","authors":"Eivind Aakhus","doi":"10.1016/j.inpsyc.2025.100060","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100060","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100060"},"PeriodicalIF":4.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment indications for antidepressants prescribed in primary health care facilities in Beijing, China.","authors":"Xinyan Zhang, Xiaoyan Nie, Luwen Shi","doi":"10.1016/j.inpsyc.2025.100057","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100057","url":null,"abstract":"<p><p>To examine the prevalence of treatment indications for antidepressants and assessed temporal trends in antidepressant prescribing for depression among adult patients in primary health care facilities (PHFs) in China. Descriptive study of antidepressant prescriptions written by primary care physicians. Setting participants: Patients aged 18 years and above in 67 PHFs in Dongcheng district in Beijing between 1 January 2014 and 31 December 2022. Deidentified information including patient demographics,antidepressants prescribed,and corresponding diagnoses were extracted from the prescribing system. The primary outcome was the treatment indications for all antidepressants prescribed between 2014 and 2022. Prescriptions were classified as on-label or off-label depending on whether the drug was approved for the indication by China's National Medical Products Administration by September 2022. A total of 42379 antidepressant prescriptions were identified between 2014 and 2022. Only 21.21 % of antidepressant prescriptions were indicated for depression. Anxiety disorders (31.43 %), insomnia (20.07 %), pain(19.12 %) and digestive system disorders (16.34 %) are also frequently prescribed antidepressants by physicians. For these indications, the most frequently prescribed antidepressant was flupentixol/melitracen and sertraline.For 36.32 % of all antidepressant prescriptions,physicians prescribed a drug for an off-label indication,especially insomnia and pain.Physicians also prescribed antidepressants for several indications that were off-label for all antidepressants, including digestive system disorders and migraine. This study found compound antidepressants are widely prescribed and used off-label indications.There is a need for more evidence to evaluate the clinical outcomes associated with off-label antidepressant indications for older adults to optimise prescribing decisions at PHFs.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100057"},"PeriodicalIF":4.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}