International psychogeriatrics最新文献

{"title":"Benzodiazepine prescription and cognitive impairment: A risk assessment.","authors":"Tomoyuki Kawada","doi":"10.1016/j.inpsyc.2025.100085","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100085","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100085"},"PeriodicalIF":4.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Dr. Kawada.","authors":"Esther Teverovsky","doi":"10.1016/j.inpsyc.2025.100086","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100086","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100086"},"PeriodicalIF":4.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting self-report measures about cognition: What matters and what to do with the data: A commentary on \"Awareness of baseline functioning and sensitivity to improvement in older people with and without mild cognitive impairment receiving a computerized functional skills training program\".","authors":"Henry W Mahncke","doi":"10.1016/j.inpsyc.2025.100082","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100082","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100082"},"PeriodicalIF":4.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis, evaluation & management of cognitive disorders in Parkinson's disease: A systematic review.","authors":"Dana Pourzinal, Charlotte Elgey, Daniel X Bailey, Jihyun Yang, Alexander Lehn, Helen Tinson, Jacki Liddle, Deborah Brooks, Sharon L Naismith, Kirstine Shrubsole, Rodney Marsh, Leander K Mitchell, Nancy A Pachana, James King, Nadeeka N Dissanayaka","doi":"10.1016/j.inpsyc.2025.100081","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100081","url":null,"abstract":"<p><strong>Background: </strong>There is considerable variability in the diagnosis, evaluation and management of cognitive disorders in Parkinson's disease (PD) across clinical services. A review of guidelines and relevant literature will provide recommendations to guide clinical decision-making. The present review aimed to summarise and critically appraise current recommendations for the diagnosis, evaluation and management of cognitive disorders in PD.</p><p><strong>Method: </strong>Five academic databases (PubMed, SCOPUS, Medline, PsycINFO, CINAHL) and five grey literature databases were systematically searched in August 2024 by two independent reviewers following PRISMA guidelines. Guidelines and systematic reviews from 2003-2024 available in English and reporting at least one relevant recommendation for the diagnosis, evaluation or management of cognitive disorders in PD were included. Quality assessment was completed using the AGREE-II tool for guidelines and AMSTAR tool for systematic reviews.</p><p><strong>Results: </strong>In total, 32 guidelines and 24 systematic reviews were included. Guideline quality ranged from moderate to high and systematic review quality from critically low to high. Articles provided recommendations for cognitive impairment in PD in terms of diagnosis, neuropsychological evaluation, treatment and care. However, recommendations for cognitive tools, care considerations, and non-pharmacological interventions were limited, despite relevant evidence from the systematic review literature.</p><p><strong>Conclusion: </strong>Significant gaps identified in processes for neuropsychological evaluations, inconsistent recommendations for non-pharmacological interventions, and limited care considerations calls for future iterations of the clinical practice guidelines for cognitive impairment in PD.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100081"},"PeriodicalIF":4.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective memory complaints at age 90 + in relation to cognition and risk of incident dementia: The 90 + Study.","authors":"Zarui A Melikyan, Colette Aguirre, Zeinah Al-Darsani, Katherine A Colcord, Annlia Paganini-Hill, Sarah E Tomaszewski Farias, Luohua Jiang, Claudia H Kawas, María M Corrada","doi":"10.1016/j.inpsyc.2025.100083","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100083","url":null,"abstract":"<p><strong>Background and aims: </strong>Associations of Subjective Memory Complaints (SMC) with cognition and future dementia are poorly understood in the oldest old (age 90 +), who have high incidence and prevalence of cognitive impairment. This study aims to (1) report SMC frequency, (2) assess cross-sectional associations between SMC and cognitive test scores, and (3) compare the abilities of SMC, Mini-mental state examination (MMSE), and cognitive diagnosis to predict dementia in the oldest old.</p><p><strong>Method: </strong>The 90 + Study participants without baseline dementia and with baseline SMC, MMSE, at least one other cognitive test, and cognitive diagnosis were included in cross-sectional analysis. A subset of this group with follow-up cognitive diagnosis was included in longitudinal analysis. Cross-sectional association between SMC and cognitive test scores was explored using linear regression. Risk of incident dementia in relation to baseline SMC, MMSE, and cognitive diagnosis was explored using three Cox regression models. Concordance Index (C-index) was used to compare model performance.</p><p><strong>Results: </strong>In 893 participants with average age 93 years (range 90-102), 43 % had SMC. Cross-sectionally, SMC were associated with lower scores on memory, language, executive function. After 3.5 years of follow-up (range 0.4-16), 325 of 789 participants developed dementia. SMC, compared with no SMC, was associated with twice the risk of incident dementia (HR=2.16, 95 %CI, 1.72-2.72; p < 0.01). SMC predicted incident dementia as well as MMSE (p = 0.12), but not as well as cognitive diagnosis (p < 0.01).</p><p><strong>Conclusions: </strong>Single SMC question might be useful to identify oldest old with cognitive impairment or at risk of dementia.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100083"},"PeriodicalIF":4.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-reported diagnosis of mental disorders, psychological distress, and risk of incident dementia in New Zealand.","authors":"Etuini Ma'u, Naaheed Mukadam, Gill Livingston, Gary Cheung, Sarah Cullum","doi":"10.1016/j.inpsyc.2025.100075","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100075","url":null,"abstract":"<p><strong>Objectives: </strong>With increasing prevalence of psychological distress and mental health disorders over recent decades, both globally and in New Zealand (NZ), it is important to understand their potential association with dementia.</p><p><strong>Design: </strong>Cohort study SETTING & PARTICIPANTS: The NZ Health Survey from 2011/12 to 2018/19 was used to create a cohort and followed up until 31st March 2022. Incident cases of dementia were identified in routinely collected health data.</p><p><strong>Measurements: </strong>Cox regression models calculated the hazard ratio for dementia for self-reported diagnoses of anxiety, depression, bipolar affective disorder, and Kessler K10 psychological distress score after adjustment for age and sex, and cardiovascular risk factors.</p><p><strong>Results: </strong>74,184 individuals aged ≥ 30 years were followed up for 452,867 person-years (mean duration of follow up 6.1 years), with 1963 (2.6 %) developing dementia. All three mental health disorders were associated with an increased hazard ratio of dementia, ranging from 1.31 (95 % CI 1.12-1.54) increased hazard for anxiety to a 2.69 (95 % CI 1.87-3.86) increased hazard for bipolar disorder. The increased dementia hazard associated with anxiety was no longer evident after adjusting for comorbid depression (HR 1.04 95 % CI 0.94-1.17). Higher K10 scores were associated with an increased dementia hazard of 2.19 (95 % CI 1.90-2.51) at the recommended score cut-off of 20.</p><p><strong>Conclusions: </strong>This study demonstrates an increased dementia risk associated with mental disorders and psychological distress in NZ. Our findings reinforce the need for timely and appropriate management of mental health distress and disorders in NZ.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100075"},"PeriodicalIF":4.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nation-wide Japanese FTD consortium FTLD-J: Utility of case review meetings.","authors":"Shunsuke Sato, Kohji Mori, Michihito Masuda, Maki Suzuki, Daiki Taomoto, Akihiro Takasaki, Kazue Shigenobu, Shinji Ouma, Shunichiro Shinagawa, Ryota Kobayashi, Yasuhiro Watanabe, Akitoshi Takeda, Yusuke Miyagawa, Aya Kawanami, Naoko Tsunoda, Kazuhiro Hara, Maki Hotta, Yosuke Hidaka, Kenji Yoshiyama, Hisanori Kowa, Masahisa Katsuno, Akira Tsujino, Takeshi Ikeuchi, Ichiro Yabe, Masayuki Nakamura, Fumiaki Tanaka, Shinobu Kawakatsu, Tetsuaki Arai, Osamu Yokota, Yuishin Izumi, Mari Yoshida, Mamoru Hashimoto, Hirohisa Watanabe, Gen Sobue, Manabu Ikeda","doi":"10.1016/j.inpsyc.2025.100078","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100078","url":null,"abstract":"<p><strong>Objectives: </strong>To clarify the characteristics of Japanese patients with frontotemporal dementia (FTD), we have established a nationwide multicenter registry named the Frontiers of Time course and Living specimen registry and Disease-modifying therapy development in Japanese patients with FTLD (FTLD-J). To ensure diagnostic consistency, we implemented case review meetings in the registry and evaluated their utility.</p><p><strong>Methods: </strong>Between February 2016 and August 2024, 269 patients with behavioral variant FTD (bvFTD), semantic dementia (SD), or progressive nonfluent aphasia (PNFA) were registered. Fifteen case review meetings, open to all participating facilities, were held, where the clinical course, neuropsychiatric-neuropsychological evaluations, and neuroimaging analysis of 238 out of 269 cases were presented. Initial diagnoses were approved or revised based on discussions among specialists regarding whether the cases met the diagnostic criteria. We examined the diagnostic stability in participants initially diagnosed with bvFTD, SD, and PNFA. Given the limited number of PNFA cases, we compared the rate of diagnostic changes between bvFTD and SD using the chi-square test.</p><p><strong>Results: </strong>Of the 126 participants enrolled as bvFTD, 75 were confirmed as bvFTD. In the remaining 51 patients, the diagnoses changed during the meeting. Of the 95 participants enrolled as SD, 77 were confirmed as SD, and in 18 cases, the diagnoses changed. Of the 17 participants enrolled as PNFA, 15 were confirmed as PNFA; bvFTD had a predominantly higher rate of diagnostic change than those with SD (p < 0.001).</p><p><strong>Conclusions: </strong>Our results suggested that case review meetings in a multicenter study may improve diagnostic consistency, especially in bvFTD.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100078"},"PeriodicalIF":4.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal support to the sociocultural stress and coping model. A 4-year follow-up of family caregivers of people with dementia.","authors":"Andrés Losada-Baltar, María Márquez-González, Brent T Mausbach, Lucía Jiménez-Gonzalo, José A Fernandes-Pires, Javier Olazarán, Laura García-García, Laura Gallego-Alberto, Isabel Cabrera","doi":"10.1016/j.inpsyc.2025.100079","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100079","url":null,"abstract":"<p><strong>Objectives: </strong>According to the sociocultural stress-and-coping model for family caregivers, caregiving stressors contribute directly to caregivers' distress. In addition, there is another path to explain this distress, as several cultural (e.g., familism) and cognitive variables (e.g., dysfunctional thoughts) have important intermediate roles in the pathway from stress to distress. In particular, coping variables appear to play important intermediary roles in this pathway. The aim of this study was to provide longitudinal support to this two-paths stress and coping model.</p><p><strong>Methods: </strong>Participants were 304 dementia family caregivers who were interviewed yearly during a 4-year period (5 assessment points). Sociodemographic variables, stressors, familism, dysfunctional thoughts about caregiving, cognitive fusion, leisure engagement, ambivalence, guilt and depressive symptoms were measured. The paths established by the sociocultural stress and coping model were tested.</p><p><strong>Results: </strong>Greater cognitive fusion, greater reaction to BPSD, increased ambivalence, increased guilt, and reduced engagement in leisure activities were associated with greater experience of depressive symptoms. However, cultural and cognitive variables (i.e., familism and dysfunctional thoughts) did not show a direct association with depressive symptoms but were associated with increased cognitive fusion and reduced engagement in leisure activities. Overall, the stress-and-coping model explained 52.45 % of the variance in depressive symptoms through the 4-year study period.</p><p><strong>Discussion: </strong>This study provides longitudinal support to the two-paths proposed by the sociocultural stress and coping model. Specifically, cultural and cognitive factors are more distally related to caregiver outcomes via their association with coping variables, which in turn appear proximally related to caregiver distress (i.e., depressive symptoms).</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100079"},"PeriodicalIF":4.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do changed behaviors predict cognitive decline in a community sample?","authors":"Jason Chen, Katya Numbers, Jessica Lo, Perminder S Sachdev, Nicole A Kochan, John D Crawford, Henry Brodaty","doi":"10.1016/j.inpsyc.2025.100076","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100076","url":null,"abstract":"<p><strong>Objective: </strong>To examine whether later-life development of neuropsychiatric symptoms (NPS) or a modified diagnosis of mild behavioral impairment (MBI) are associated with future cognitive decline.</p><p><strong>Design: </strong>Prospective Cohort Study SETTING: Community PARTICIPANTS: 823 individuals without dementia aged 70-90 years from the Sydney Memory and Ageing Study, followed over six years.</p><p><strong>Measurements: </strong>Biennially, cognition was assessed through neuropsychological testing, and clinical diagnoses of mild cognitive impairment (MCI) and dementia were made by expert consensus. NPS was evaluated using the Bayer Activities of Daily Living scale and Neuropsychiatric Inventory (NPI). Based on published algorithms, modified diagnoses of MBI (MBI-Lite) were obtained. The relationship between behavior at baseline and neuropsychological test scores six years later was examined using linear regression. Cox regression was performed to evaluate associations between behavior and both incident dementia and incident categorical progression. Apolipoprotein E ε4 allele carrier status and cardiovascular disease risk were controlled for in all analysis.</p><p><strong>Results: </strong>Higher total NPI scores were associated with worse global cognition scores at six years (β = -0.03, p = .007) and increased risk of incident dementia over six years (HR=1.06, p = .003). Presence of NPS of clinically significant severity and frequency was associated with worse global cognition scores for those with normal cognition (β = -0.44, p = .001), but not those with MCI at baseline (β = 0.22, p = .389). Diagnosis with MBI-Lite, was also associated with worse global cognition scores (β = -0.28, p = .028).</p><p><strong>Conclusions: </strong>Certain measures of NPS in cognitively normal older adults may herald future cognitive decline and be useful for early diagnosis and dementia research.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100076"},"PeriodicalIF":4.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping of validated apathy scales onto the apathy diagnostic criteria for neurocognitive disorders.","authors":"K Sankhe, K K Bawa, D S Miller, D Bateman, J L Cummings, L Ereshefsky, M Husain, Z Ismail, V Manera, J Mintzer, H J Moebius, M Mortby, A Porsteinsson, P Robert, K L Lanctôt","doi":"10.1016/j.inpsyc.2025.100074","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2025.100074","url":null,"abstract":"<p><strong>Background: </strong>Diagnostic criteria for apathy in neurocognitive disorders (DCA-NCD) have recently been updated.</p><p><strong>Objectives: </strong>We investigated whether validated scales measuring apathy severity capture the three dimensions of the DCA-NCD (diminished initiative, diminished interest, diminished emotional expression).</p><p><strong>Measurements: </strong>Degree of mapping (\"not at all\", \"weakly\", or \"strongly\") between items on two commonly used apathy scales, the Neuropsychiatric Inventory-Clinician (NPI-C) apathy and Apathy Evaluation Scale (AES), with the DCA-NCD overall and its 3 dimensions was evaluated by survey.</p><p><strong>Design: </strong>Survey participants, either experts (n = 12, DCA-NCD authors) or scientific community members (n = 19), rated mapping for each item and mean scores were calculated. Interrater reliability between expert and scientific community members was assessed using Cohen's kappa.</p><p><strong>Results: </strong>According to experts, 9 of 11 (81.8%) NPI-C apathy items and 6 of 18 (33.3%) AES items mapped strongly onto the DCA-NCD overall. For the scientific community group, 10 of 11 (90.9%) NPI-C apathy items and 7 of 18 (38.8%) AES items mapped strongly onto the DCA-NCD overall. The overall mean mapping scores were higher for the NPI-C apathy compared to the AES for both expert (t (11) = 3.13, p = .01) and scientific community (t (17) = 3.77, p = .002) groups. There was moderate agreement between the two groups on overall mapping for the NPI-C apathy (kappa= 0.74 (0.57, 1.00)) and AES (kappa= 0.63 (0.35, 1.00)).</p><p><strong>Conclusions: </strong>More NPI-C apathy than AES items mapped strongly and uniquely onto the DCA-NCD and its dimensions. The NPI-C apathy may better capture the DCA-NCD and its dimensions compared with the AES.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100074"},"PeriodicalIF":4.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}